Con-current Oral Abstract Presentations Session 2

Biomaterial Immuno-Engineering (Symposia)


Materials designs toward macrophage- and dendritic cell-targeted immunotherapeutics

J. A. Hubbell, M. A. Swartz, E. Simeoni, A. Stano, C. Nembrini, S. N. Thomas, S. Hirosue, A. J. van der Vlies, C. P. O'Neil, D. Velluto;



A materials-based approach for immunotherapeutics design: Mechanisms of thiol-associated complement activation of dendritic cells

S. N. Thomas, S. T. Reddy, A. J. van der Vlies, S. Hirosue, J. A. Hubbell, M. A. Swartz;

Ecole Polytechnique Federale de Lausanne, Lausanne, SWITZERLAND.


Injectable Hydrogels as ‘Vaccination Nodes’ for Anti-Tumor Immunotherapy

D. J. Irvine, Y. Hori, A. M. Winans, C. C. Huang, E. M. Horrigan;

MIT, Cambridge, MA.


Foreign Body Reactions-Induced Cancer Metastasis

L. Wu, C-Y. Ko, L. Tang;

Univ. of Texas at Arlington, Arlington, TX.


Local Regulation of Cytokines with Antibody-Functionalized Materials

N. R. Washburn, L. Sun;

Carnegie Mellon Univ., Pittsburgh, PA.


Enhanced Cell Migration and Efficient In-vivo Immune-modulation by Combinatorial, Single Formulation Delivery of siRNA, DNA vaccine and Chemokines

A. Singh, S. Suri, K. Roy;

The Univ. of Texas at Austin, Austin, TX.


Microparticle-Based Cellular Arrays For Vaccine Development And Optimization

A. P. Acharya, B. G. Keselowsky;

Univ. of Florida, Gainesville, FL.

Drug Delivery in Tissue Engineering and Regenerative Medicine


Sequential delivery of angiogenic cytokines from fibrin-based hydrogels in a murine critical limb ischemic model

H. Layman, X. Li, S. M. Pham, F. M. Andreopoulos;

Univ. of Miami, Miami, FL.


Local erythromycin delivery in a rat osteolysis model

D. C. Markel1, R. Zhang2, M. Hawkins2, P. Wooley3, W. Ren4;

1Providence Hosp., Southfield, MI, 2Stryker Orthopedics, Mahwah, NJ, 3Orthopedic Res. Inst., Wichita, KS, 4Wayne State Univ., Detroit, MI.


Novel Porous Scaffold for Releasing Bioactive Molecules

A. M. Nair, J. Yang, L. Tang;

The Univ. of Texas at Arlington, Arlington, TX.


Polymer-coated Albumin Nanoparticles for Bone Morphogenetic Protein-2 Delivery: Pharmacokinetics and Osteoinduction Study

S. Zhang, C. Kucharski, H. Uludag;

Univ. of Alberta, Edmonton, AB, CANADA.


Local Delivery of PDGF-BB from Polyurethane Scaffold Enhances Tissue Regeneration in Rat Excisional Wounds

b. li, J. M. Davidson, S. A. Guelcher;

vanderbilt Univ., nashville, TN.


Incorporation of Double-Walled Microspheres into Polymer Nerve Guides for the Sustained Delivery of Neurotrophic Factors

L. E. Kokai;

Univ. of Pittsburgh, Pittsburgh, PA.


Localized Hydrogel Delivery to the Spinal Cord

M. S. Shoichet1, C. E. Kang1, M. D. Baumann1, Y. Wang1, K. Vulic1, J. Stanwick1, C. H. Tator2;

1Univ. of Toronto, Toronto, ON, CANADA, 2Toronto Western Res. Inst., Toronto, ON, CANADA.


Matrix Metalloproteinase Degradable PEG Hydrogel with High DNA/PEI Loading for Tissue Engineering

Y. Lei, T. Segura;

Univ. of California, Los Angeles, Los Angeles, CA.

Orthopedic Bearing Surfaces


Post-implantation Evaluation and Damage Characterization of Retrieved Dynamic Antibiotic Cement Spacers

D. Jaekel1, G. Klein2, J. Day3, H. Levine2, P. Shah1, H. Patel1, A. Cohen1, S. Kurtz1;

1Drexel Univ., Philadelphia, PA, 2Hackensack Univ. Med. Ctr., Hackensack, NJ, 3Exponent, Inc, Philadelphia, PA.


Wear Performance Of Large Diameter Differential Hardness Metal-on-Metal and Ceramic-on-Metal Hip Bearings

S. Nambu1, J. Moseley1, M. Carroll1, F. Billi2;

1Wright Med. Technology, Arlington, TN, 2Los Angeles Orthopedic Hosp., Los Angeles, CA.


Crosslinking of UHMWPE Without Radiation

D. Sun1, L. Terrill2, S. Lin2, W. Petty2, R. Tsay3, G. Chou3;

1Taiwan Scientific Corp., Taipei, TAIWAN, 2Exactech, Inc., Gainesville, FL, 3Inst. of BioMed. Engineering, Natl. Yang-Ming Univ., Taipei, TAIWAN.


Vitamin E Diffusion Process Elevates Remelting of Irradiation Crosslinked UHMWPE

S-S. Yau1, K-P. Le1, J. W. Blitz1, J. H. Dumbleton2;

1Stryker Orthopaedics, Mahwah, NJ, 2Consultancy in Med. Devices, Ridgewood, NJ.


Biostability, Biocompatibility and Mechanical Properties of a Hyaluronan-Polyethylene Copolymer

R. Oldinski1, M. Gobek1, S. James1, M. Staiger2;

1Colorado State Univ., Fort Collins, CO, 2Univ. of Canterbury, Christ Church, NEW ZEALAND.


Hip Simulator Wear Testing Of Polycarbonate Urethane Acetabular Cups as Compared to Ultra High Molecular Weight Polyethylene Cups

K. R. St. John1, N. J. Hallab2, S. M. Kurtz3;

1Univ. of Mississippi Med. Ctr., Jackson, MS, 2Bioengineering Solutions Inc., Oak Park, IL, 3Exponent, Philadelphia, PA.


Wear and friction of a multi-bearing acetabular system

A. Kamali;

Smith & Nephew Orthopaedics Ltd, Leamington Spa, UNITED KINGDOM.


Novel Nanostructured Coatings Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells

S. Dimitrievska1, R. Lima1, M. Basil1, J. Antoniou2, A. Petit3, M. N. Bureau1;

1Natl. Res. Council Canada, Boucherville, QC, CANADA, 2Orthopaedic Res. Lab., Royal Victoria Hosp.,, Montreal, QC, CANADA, 3Dept. of Orthopaedic, Jewish Gen. Hosp.- SBMD, Montreal, QC, CANADA.

PEEK Biomaterials: From Isoelastic Hip Stems to Bone Scaffolds (Symposia)


 Incorporating Hydroxyapatite and Porosity in PEEK for Orthopaedic and Spine Applications

R. K. Roeder;

Univ. of Notre Dame, Notre Dame, IN.


Plasma Surface modification of PEEK to improve primary human osteoblast cell adhesion and function

A. H. C. Poulsson, R. G. Richards;

AO Res. Inst., Davos Platz, SWITZERLAND.


New Technique for Crystallinity Measurements of Medical Grade PEEK Utilizing FTIR-microscopy

D. Jaekel, F. Medel, S. Kurtz;

Drexel Univ., Philadelphia, PA.


In Vitro Analysis of Novel Porous PEEK Orthopedic Biomaterial

B. Landy1, S. VanGordon1, M. Jarman-Smith2, P. McFetridge1, V. Sikavitsas1;

1Univ. of Oklahoma, Norman, OK, 2Invibio Ltd.,, Lancashire FY5 4QD, UNITED KINGDOM.


Plasma Spray Deposition of Titanium and Hydroxyapatite on PEEK and Carbon Fiber-Reinforced PEEK

P. Robotti1, S. Vedova1, A. Fabbri1, C. Migliaresi2, V. Fontanari2;

1Eurocoating Spa, Cirè-Pergine, Trento, ITALY, 2Univ. of Trento, Trento, ITALY.


Exploring the Wear of a PEEK All-Polymer Articulation for Spinal Applications

H. Austin1, M. Powell2, J. Medley1, D. Langohr1;

1Univ. of Waterloo, Waterloo, ON, CANADA, 2Medtronic, Spine & Biologics, Memphis, TN.


Fatigue Crack Initiation and Propagation Behavior of Neat PEEK under Notched Conditions

M. Sobieraj1, J. Murphy1, J. Brinkman1, S. Kurtz2, C. Rimnac1;

1Case Western Reserve Univ., Cleveland, OH, 2Exponent, Inc. and Drexel Univ., Philadelphia, PA.

Peptide Functionalized Materials for Directed Cell Response


S1P-Mediated Endothelial Cell Migration into Porous Poly(ethylene glycol) Modular Scaffolds Formed in the Presence of HepG2 Cells

E. A. Scott, M. D. Nichols, D. L. Elbert;

Washington Univ. in St. Louis, St. Louis, MO.


Bio-Artificial Matrix for Therapeutic Vascularization

E. A. Phelps, A. M. Wojtowicz, P. M. Thulé, W. R. Taylor, A. J. García;

Georgia Inst. of Technology, Atlanta, GA.


Engineered Synthetic Platelets and Their Augmentation of Hemostasis

J. P. Bertram, E. B. Lavik;

Yale Univ., New Haven, CT.


Sequential Click Reactions for Synthesizing and Patterning 3D Cell Microenvironments

C. A. DeForest1, E. A. Sims1, B. D. Polizzotti2, K. S. Anseth2;

1Univeristy of Colorado, Boulder, CO, 2Univeristy of Colorado / HHMI, Boulder, CO.


Molecularly Engineered PEG Hydrogels with Enhanced Proteolysis

J. Patterson, J. A. Hubbell;

Ecole Polytechnique Fédérale de Lausanne, Lausanne, SWITZERLAND.


A Dynamic Ligand Presentation System to Examine Adhesive Ligand “Temporal Threshold”

T. A. Petrie1, E. A. Phelps1, M. Wirkner2, A. Del Campo2, A. J. Garcia1;

1Georgia Inst. of Technology, atlanta, GA, 2Max-Planck-Inst. für Metallforschung, Stuttgart, GERMANY.


Osteoinductive Polymer Scaffolds for Bone Tissue Engineering: A Surface-Modification Approach

D. A. Lee1, C. T. Laurencin2;

1Drexel Univ., Philadelphia, PA, 2Univ. of Connecticut, Farmington, CT.


Osteogenic differentiation of human mesenchymal stem cells directed by extracellular matrix-mimicking ligands in a biomimetic self-assembled peptide amphiphile nanomatrix

J. Anderson, M. Kushwaha, A. Tambralli, S. L. Bellis, R. P. Camata, H-W. Jun;

Univ. of Alabama at Birmingham, Birmingham, AL.

Scaffolds for Tissue Engineering: Basic Principles, Processing Methods and Novel Developments


Epicardial placement of an elastic, biodegradable patch induces muscle tissue similar to embryonic myocardium in the post-infarcted wall and preserves cardiac functional reserve

K. L. Fujimoto1, K. Tobita1, J. Guan1, Y. Hong1, K. E. Yutzey2, B. B. Keller1, W. R. Wagner1;

1Univ. of Pittsburgh, Pittsburgh, PA, 2Cincinnati Children's Med. Ctr., Cincinnati, OH.


Integrated Dual Scaffolding System for Engineering of Muscle-Tendon Junctions

M. R. Ladd, S. Lee, A. Atala, J. J. Yoo;

Wake Forest Inst. for Regenerative Med., Winston-Salem, NC.


Bilayered Scaffold for Engineering Fully Cellularized Small Diameter Blood Vessels

Y. Ju, S. Lee, J. Choi, A. Atala, J. J. Yoo;

Wake Forest Inst. for Regenerative Med., Winston-Salem, NC.


Evaluation of ECM components in Biodegradable Hydrogels for Chondrogenic Differentiation of Mesenchymal Stem Cells

L. H. Nguyen, N. Guckert, A. Kapuria, K. Roy;

Univ. of Texas at Austin, Austin, TX.


Preparation of Artificail Fibrous Nano Extracellular Matrices on Cell Surface for Layered Tissues

K. Kadowaki, M. Matsusaki, M. Akashi;

Graduate Sch. of Engineering, Osaka Univ., Osaka, JAPAN.


Crystallization mechanism of the PVA-Theta hydrogel as load bearing synthetic articular cartilage

H. Bodugoz Senturk1, C. E. Macias2, O. K. Muratoglu1;

1Massachusetts Gen. Hosp./Harvard Med. Sch., Boston, MA, 2Massachusetts Gen. Hosp., Boston, MA.


An elastic, biodegradable cardiac patch induces muscle regeneration with preserved cardiac function in a porcine myocardial infarction model

K. L. Fujimoto, K. Tobita, J. Guan, R. Hashizume, Y. Hong, T. Ota, B. B. Keller, W. R. Wagner;

Univ. of Pittsburgh, Pittsburgh, PA.


Novel Poly(ethylene glycol) Cloud Point Microspheres Used To Form Macroporous Scaffolds

M. D. Nichols, E. A. Scott, D. L. Elbert;

Washington Univ. in Saint Louis, Saint Louis, MO.