About

Measurements and Standards for Advancing the Development of Tissue-Engineered Medical Products: The regenerative medicine industry has identified a lack of reliable methods for characterizing products as “possibly the single greatest challenge for the field”. Several attempts to legislate efforts to develop regenerative medicine standards have been proposed as bills in the U.S. congress. Product quality attributes should be well-defined and validated measurement processes are required to establish that manufactured products possess these attributes. This session will examine how products may be characterized for release and the measurements and standards that can support these efforts. In addition, needs for improved measurements and new standards may be emphasized. The speakers will focus on efforts to bring products to market, how the products are characterized, the key measurements for their release and how documentary standards may assist in this process. Relevant stakeholders from different sectors will be recruited as speakers: standards organizations, universities, government and industry. Speakers will place particular focus on needs in the current measurement and standards infrastructure and will highlight opportunities for future research efforts.

Abstracts

3:15 p.m. 65. Use of Quality-by-Design methods to develop scalable, biologic manufacturing processes, J. Jensen*(1), M. Gilkey(1), K. Sears(2), M. Bukys(2), M. Majumder(1), K. Finney(1), (1)Trailhead Biosystems Inc., Cleveland, OH, (2)Cleveland Clinic, Cleveland, OH
3:30 p.m. 66. A Biodegradable Scaffold for Manufacturing Stem Cell Derived Retinal Pigment Epithelium Tissue, V. Khristov*(1), N. Hotaling(2), A. Maminishkis(2), K. Bharti(2), S. Miller(2), (1)National Eye Institute, Washington, DC, (2)National Eye Institute, Bethesda, MD
3:45 p.m. 67. Towards Standardization of MicroCT as a Tool for Characterizing Tissue Engineered Scaffolds, M. Dreher*(1), S. Nagaraja(1), J. Navarro(2), M. Wang(3), M. Din(2), J. Fisher(2), (1)US Food and Drug Administration/ Center for Devices and Radiological Health, Silver Spring, MD, (2)University of Maryland, College Park, MD, (3)JWE LLC, Fulton, MD
4:00 p.m. 68. Measurement Assurance System for Cell Culture Scaffold, F. Payvandi*, W. Lau, 3D Biotek LLC, Bridgewater, NJ
4:15 p.m. 69. SQuIRE - Simple Quantitative Imaging of Retinal Epithelial Cells for Reproducible Cell Metrics, N. Schaub*(1), N. Hotaling(2), K. Bharti(2), C. Simon(1), (1)National Institute of Standards and Technology, Gaithersburg, MD, (2)National Institutes of Health, Bethesda, MD
4:30 p.m. 70. Measurement Assurance for Assessing Nanofiber Diameter, C. G. Simon*, N. A. Hotaling, NIST, Gaithersburg, MD

Dental Implants

Abstracts

3:15 p.m. 71. Interfacial Fracture Toughness of Dental Adhesive Formulations Containing Antimicrobial Di-vinyl Monomers, Y. Delaviz*, T. Liu, Y. Finer, B. Shokati, J. P. Santerre, University of Toronto, Toronto, ON
3:30 p.m. 72. Design of Multifunctional Ionic liquid Coatings for Zirconia Dental Implant Applications, P. Sandhu*(1), I. Gindri(2), D. Siddiqui(3), D. Rodrigues(3), K. Palmer(3), (1)University of Texas at Dallas, murphy, TX, (2)University of Texas at Dallas, Richardson, TX, (3)UT Dallas, Richardson, TX
3:45 p.m. 73. The Use of Allogeneic Block Bone Grafts as an Effective Bone Substitute during Implant Insertion, D. J. Cohen*, K. M. Scott, K. Sahingur, B. D. Boyan, Z. Schwartz, Virginia Commonwealth University, Richmond, VA
4:00 p.m. 74. An in vitro Evaluation on Biocompatibility of the Selected MAX Phases: Ti3AlC2, Ti3SiC2 and Ti2AlN, K. Chen*(1), Q. Deng(2), M.-H. Kang(1), J.-U. Baek(1), Y.-H. Koh(3), Q. Huang(2), H.-E. Kim(1), (1)Seoul National University, Seoul, Republic of Korea, (2)Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Ningbo, China,
4:15 p.m. 75. In Vitro Tests to Evaluate the Surface of Dental Implants in Simulated Oral Environment, S. Sridhar*(1), K. Palmer(1), T. G. Wilson(2), P. Valderrama(2), D. A. Siddiqui(1), F. Wang(1), L. Zhan(1), D. C. Rodrigues(1), (1)University of Texas at Dallas, Richardson, TX, (2)Private practice of periodontics, Dallas, TX
4:30 p.m. 76. The impact of in vitro accelerated aging, approximating 30 and 60 years in vivo, on Commercially Available Zirconia Dental Implants, M. Monzavi*(1), H. Nowzari(2), S. Noumbissi(3), (1)Loma Linda University, Malibu, CA, (2)Loma Linda University, Beverly hills, CA, (3)Loma Linda University, Silver Spring, MD

Device - and implant-based drug delivery

About

Device- and implant-based drug delivery: Medical devices and implants provide unique access to diseased or healing tissue and can be used as a platform for local drug delivery. Drug delivery can be the primary goal of implants or biomaterials can augment device function by providing an avenue for drug delivery that may aid in disease treatment, device functionality, or implant longevity. This session will focus on designs for new drug delivery devices and methods to incorporate or improve drug delivery strategies from existing devices.

Abstracts

3:15 p.m. 77. A Thin Porous Sheath to Mitigate the Foreign Body Response: Implications for Drug Delivery, K. Willson*, B. Ratner, University of Washington, Seattle, WA
3:30 p.m. 78. Microfabricated immune-isolating devices for transplanting therapeutic cells in vivo, S. Bose*, L. Volpatti, V. Yesilyurt, R. Langer, D. Anderson, MIT, Cambridge, MA
3:45 p.m. 79. Tuning Strategies for Sequential Delivery of Multiple Active Biological Factors, L. Kuhn*, E. Jacobs, J. Alhamdi, M. Hurley, G. Gronowicz, University of Connecticut Health Center, Farmington, CT
4:00 p.m. 80. Unveiling Macrophage Populations and Mechanisms Driving the Better Remodeling Outcomes Associated with Shifting Phenotype in the Host Response Against Biomaterials, D. Hachim*, S. T. LoPresti, B. N. Brown, McGowan Institute, Bioengineering Department, University of Pittsburgh, Pittsburgh, PA
4:15 p.m. 81. Controlled Insertion of Microneedle for Enhanced Intrascleral Drug Delivery, S. H. Park*(1), D. H. Jo(2), K. J. Lee(1), J. H. Kim(2), WH Ryu(1), (1)Yonsei University, Seoul, Republic of Korea, (2)Seoul National University Hospital, Seoul, Republic of Korea
4:30 p.m. 82. Smart Contact Lens for Ocular Theranosis, D. H. Keum*, S. K. Hahn, POSTECH, Pohang, Republic of Korea

Immunomodulation 1

Abstracts

3:15 p.m. 83. Microgels presenting SA-FasL achieve allogeneic islet graft acceptance without chronic immunosuppression, D. M. Headen*(1), J. Weaver(1), E. Yolcu(2), H. Shirwan(2), A. J. García(1), K. B. Woodward(3), H. Zhao(3), P. Shrestha(3), (1)Georgia Institute of Technology, Atlanta, GA, (2)University of Louisville School of Medicine, Louisville, KY, (3)University of L
3:30 p.m. 84. Impact of Macrophage Phenotype on Engineered Tissue Vascularization, P. L. Graney*(1), S. Ben-Shaul(2), S. Levenberg(2), K. L. Spiller(1), (1)Drexel University, Philadelphia, PA, (2)Technion-Israel Institute of Technology, Haifa, Israel
3:45 p.m. 85. A Dual-Microparticle System Prevents and Reverses Type 1 Diabetes in Non-Obese Diabetic Mice, J. M. Stewart*(1), J. S. Lewis(2), C. Q. Xia(1), M. J. Clare-Salzler(1), C. H. Wasserfall(1), M. A. Atkinson(1), B. G. Keselowsky(1), (1)University of Florida, Gainesville, FL, (2)University of California, Davis, Davis, CA
4:00 p.m. 86. Modulatory Mechanisms of Immune Host Response and Antimicrobial Peptide Expression induced by Poly(4-Hydroxy Butyrate), C. Pineda*, G. S. Hussey, R. M. Giglio, A. M. Ramirez, B. M. Sicari, R. Londono, R. M. Gandhi, S. F. Badylak, University of Pittsburgh, Pittsburgh, PA
4:15 p.m. 87. Amino Acid Chirality in Particle-based Scaffolds for Localized Control of Adaptive Immune Response In Vivo, D. R. Griffin, E. Sideris, W. Weaver, D. Di Carlo, P. Scumpia, T. Segura*, University of California Los Angeles, Los Angeles, CA
4:30 p.m. 88. Biomaterial Cues for Modulating Macrophage and Schwann Cell Phenotype Following Peripheral Nerve Injury, M. R. Wrobel*, H. G. Sundararaghavan, Wayne State University, Detroit, MI

International College of Fellows Debate: Clinical Studies aer the only True Predictor of the Safety and Efficacy for all new Medical Technologies

About

The “Special Fellows Session” is organized by the International College of Fellows of Biomaterials Science and Engineering (ICF-BSE). Fellows of Biomaterials Science and Engineering (FBSE) are elected in a worldwide competition every four years and are among the most accomplished in the field of biomaterials. Special Fellows Sessions explore important and sometimes controversial topics and are designed to be interactive: the audience will have an opportunity to participate in the debate and will vote on the issues. A group of six prominent Fellows will highlight the perceived strengths and weaknesses of in vitro, animal, and other test systems. Three Fellows will argue in favor of these systems and their potential to predict and replace human studies while three other Fellows will provide arguments highlighting areas where these systems fall short. This debate touches on some of the most important issues in biomaterials science, from animal rights to FDA approval of new medical technologies. The audience will hear a series of arguments that will provide a comprehensive overview of this complex topic. Some of our previous “Special Fellows Sessions” have explored whether we will ever be able to regenerate a complete human arm (WBC Chengdu, 2012), looked at the tension between basic research and translational research (ESB Liverpool, 2014) and if nanotechnology is more hype than hope (WBC Montreal, 2016).

Invited Speaker(s)

Joachim Kohn, PhD
Dave Grainger, PhD
Peter Ma, PhD, FBSE
Jack Ricci, PhD, FBSE
Paul Santerre, PhD, FBSE
Frederick J. Schoen, MD, PhD
Michael V. Sefton, ScD, FBSE

Panel Discussion: Functional Osseointegration

About

The objective of the session is to stimulate discussion on the topic of implant integration with bone, specifically in the context of “function”. The mechanoresponsive relationship of an implant-bone interface to biomechanical loads is studied at multiple length scales. This interdisciplinary session will focus on the controversial topic of immediate and delayed biomechanical loading on implants (dental and orthopedics). As such, this session invites abstracts related to basic/applied sciences and engineering, and clinical translation concepts that will discuss about osseointegration at multiple length scales (joint, tissue and cell) within the context of function.

Invited Speaker(s)

Stuart Goodman, MD, PhD
Danieli Rodrigues, PhD
Antonio Nanci, PhD
Sunita Ho, PhD

Regulating Stem Cell Differentiation

About

Regulating Stem Cell Differentiation: The development of well-defined biomimetic microenvironments for the regulation of stem cell behavior and bioengineering of human tissues and disease models requires a solid understanding of the nanoscale properties of polymers and cell-matrix interactions, and application of environmentally and biologically benign nanobioengineering techniques. The focus of this symposium is on the design and fabrication of scaffold architecture that ‘selects and captures’ stem cells for differentiation into specific cellular phenotypes. Biomaterial and cell biology research will be equally emphasized.

Abstracts

3:15 p.m. 89. Microstructured and Hydrophilic Titanium Surfaces Mediate Semaphorin Signaling to Regulate Bone Modeling during Implant Osseointegration, E. M. Lotz*, S. L. Hyzy, Z. Schwartz, B. D. Boyan, Virginia Commonwealth University, Richmond, VA
3:30 p.m. 90. Layer-by-layer assembled ‘multi-trilayer’ nanofilm for high encapsulation efficiency of protein and its application in induced pluripotent stem cell culture, U. Han*, J. Hong, Chungang Univ., Seoul, Republic of Korea
3:45 p.m. 91. Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed Graphene Circuits, M. Uz*, S. Das, S. Ding, M. Lentner, J. Hondred, A. Cargill, D. Sakaguchi, S. Mallapragada, J. Claussen, Iowa State University, Ames, IA
4:00 p.m. 92. Wharton’s Jelly derived mescenchymal stem cells form functional neurospheres with silica spinal cord replica, S. W. TANG*(1), F. Lv(2), W. Yuen(3), V. Leung(2), Y. W. Lam(1), (1)City University of Hong Kong, Hong Kong SAR, Hong Kong, (2)The University of Hong Kong, Hong Kong SAR, Hong Kong, (3)HealthBaby Biotech (Hong Kong) Co., Ltd., Hong Kong SAR, Hong Kong
4:15 p.m. 93. Development and Evaluation of a Physiologically Relevant Bioreactor for Bone Tissue Engineering, A. Ravichandran*(1), W. Feng(1), J. Lim(1), M. Seow Khoon Chong(1), J. K. Y. Chan(2), S.-H. Teoh(1), (1)Nanyang Technological University, Singapore, Singapore, (2)National University of Singapore, Singapore, Singapore
4:30 p.m. 94. Tunable Biotransport Properties in Gelatin Hydrogels for Hematopoietic Stem Cell Culture, A. E. Gilchrist*, B. P. Mahadik, S. Lee, Y. Hu, B. A. Harley, University of Illinois at Urbana-Champaign, Urbana, IL

Tissue Engineering Scaffold Fabrication

About

Tissue Engineering Scaffold Fabrication: The field of tissue engineering relies extensively on the use of 3D scaffolds to provide the appropriate microenvironment for tissue regeneration. This session will focus on the state-of-the-art technologies and methods in the development of biomimetic scaffolding materials and the application of these scaffolds to modulate desirable cellular responses and various tissue regeneration.

Abstracts

3:15 p.m. 107. Gradient Nano-Engineered In Situ Forming Hydrogel for Osteochondral Tissue Regeneration in Rabbit, J. Radhakrishnan*, A. Manigandan, A. Subramanian, S. Sethuraman, SASTRA University, Thanjavur, India
3:30 p.m. 108. 3D Printing of Poly(glycerol sebacate) Elastomeric Scaffolds via Thiol-Norbornene Photochemistry, Y.-C. Yeh*, L. Ouyang, C. Highley, J. Burdick, University of Pennsylvania, Philadelphia, PA
3:45 p.m. 109. Microporous scaffolds assembled from microgel building blocks for hMSC delivery and bone tissue engineering, S. Xin*, O. M. Wyman, D. L. Alge, Texas A&M University, College Station, TX
4:00 p.m. 110. Completely Biological Allogenic Engineered Tissue for Surgical and Transcatheter Heart Valve Application, Z. Syedain*(1), M. Young(2), B. Tefft(2), A. Lerman(2), R. Tranquillo(1), (1)University of Minnesota, Minneapolis, MN, (2)Mayo Clinic, Rochester, MN
4:15 p.m. 111. Manipulation of Extracellular Matrix Composition to Study Disease Etiology in ex vivo Organ Cultures, A. M. Porras*, H. Rao, C. Brandt, K. S. Masters, University of Wisconsin-Madison, Madison, WI
4:30 p.m. 112. Stereolithography of Engineered Tissues Containing Interpenetrating Vascular Networks, B. Grigoryan*, D. Sazer, S. Paulsen, A. Zaita, P. Greenfield, A. Ta, J. Miller, Rice University, Houston, TX

*BTI* Measurements and Standards for Advancing the Development of Tissue-Engineered Medical Products

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Abstracts

Dental Implants

Abstracts

Device - and implant-based drug delivery

About

Abstracts

Immunomodulation 1

Abstracts

International College of Fellows Debate: Clinical Studies aer the only True Predictor of the Safety and Efficacy for all new Medical Technologies

About

Abstracts

Invited Speaker(s)

Panel Discussion: Functional Osseointegration

About

Abstracts

Invited Speaker(s)

Regulating Stem Cell Differentiation

About

Abstracts

Tissue Engineering Scaffold Fabrication

About

Abstracts

BTI Measurements and Standards for Advancing the Development of Tissue-Engineered Medical Products