About

Injectable Biomaterials for Delivery of Cell, Gene and Protein Therapy: Injectable biomaterials are becoming increasingly popular for the delivery of therapeutic agents. Therapeutic agents such as cells, genetic materials, and proteins offer the possibility to treat a variety of conditions, and the use of injectable biomaterials provides site-specific delivery and immunoprotection for these encapsulated agents. Overall, both synthetic and naturally derived injectable biomaterials have shown potential in the treatment of conditions such as bone defects, cancer, and myocardial infarction.

Abstracts

10:15 a.m. 427. Intramuscular Injection of Stem Cells in an In Situ-Gelling Hydrogel Scaffold: Cell Retention, Angiogenesis, and Inflammation, S. A. Young*(1), L. E. Flynn(2), B. G. Amsden(1), (1)Queen's University, Kingston, ON, (2)Western University, London, ON
10:30 a.m. 428. M1 macrophage-loaded hydrogels reduce the viability and proliferation of hepatocellular carcinoma in vitro and in vivo, A. Guerra*(1), O. Yeung(2), N. Man(2), W. Kao(1), (1)University of Wisconsin-Madison, Madison, WI, (2)University of Hong Kong, Hong Kong, Hong Kong
10:45 a.m. 429. Injectable Guest-Host Hydrogels for Cell and IL-10 Co-Delivery to the Heart, M. H. Chen*, C. W. Chen, J. E. Mealy, M. F. Arisi, R. Kanade, S. Zaman, J. J. Chung, P. Atluri, J. A. Burdick, University of Pennsylvania, Philadelphia, PA
11:00 a.m. 430. Injectable Biomimetic Liquid Crystalline Scaffolds enhance Muscle Stem Cell Transplantation, B. D. Cosgrove*(1), E. Sleep(2), M. T. McClendon(2), A. T. Preslar(3), R. D. Haynes(4), T. J. Meade(5), S. I. Stupp(2), H. M. Blau(4), (1)Cornell University, Ithaca, NY, (2)Northwestern University, Chicago, IL, (3)Northwestern University, Evanston, IL, (4
11:15 a.m. 431. Injectable and inherently vascularizing SIPN for delivering cells to the subcutaneous space, R. Mahou*(1), D. k. y. Zhang(2), A. E. Vlahos(1), S. V. Michael(1), (1)University of Toronto, Toronto, ON, (2)Institute of Biomaterials and Biomedical Engineering, Toronto, ON
11:30 a.m. 432. Biodegradable, Imagable, Injectable, and Thermosensitive Hydrogels for Cardiac Cell Therapy, H. Niu*, J. Guan, X. Li, Z. Fan, The Ohio State University, Columbus, OH
11:45 a.m. 433. Multifunctional Biodegradable Porous Microspheres to Act as Stem Cell Delivery Vehicles and Local Drug Delivery Platform for Bone Tissue Regeneration, E. S. Sandhurst*, H. Sun, University of South Dakota, Sioux Falls, SD
12:00 noon 434. Characterization of Protein Interactions with Molecularly Imprinted Hydrogels that Possess Engineered Affinity for High Isoelectric Point Biomarkers, J. R. Clegg*, J. X. Zhong, A. S. Irani, J. Gu, N. A. Peppas, The University of Texas at Austin, Austin, TX

STUDENT AWARD FOR OUTSTANDING RESEARCH

*BTI* Translational Orthopaedic Biomaterials

About

Translational Orthopaedic Biomaterials: The research, development, education, and outreach of orthopaedic biomaterials (metal, ceramic, polymer, composite, etc.) are welcome. It is expected that the past, present, and future of orthopaedic biomaterials will be presented by well-respected researchers. Emerging translational orthopaedic biomaterials and related challenges and industrial and government regulations will be discussed. Topics will also include advanced cell culture and animal models for translational orthopaedic biomaterials studies.

Abstracts

10:15 a.m. 387. Invited Speaker, Thomas Webster, PhD
10:45 a.m. 389. Microribbon-based hydrogels guided mesenchymal stem cells to undergo endochondral ossification in vivo, B. Conrad*, F. Yang, Stanford University, Stanford, CA
11:00 a.m. 390. Clinical Translation of Porous PEEK for Spinal Applications: From Benchtop to Bedside, F. B. Torstrick*(1), D. L. Safranski(2), N. Evans(1), R. E. Gulberg(1), K. Gall(3), (1)Georgia Institute of Technology, Atlanta, GA, (2)Vertera Spine, Inc., Atlanta, GA, (3)Duke University, Durham, NC
11:15 a.m. 391. Micro-and Nano-scale Surface Topographic Characterization of a Novel PEEK Titanium Structural Composite, S. Fang*(1), J. Jiang(2), (1)Orthofix Inc., Lewisville, TX, (2)University of Texas at Arlington, Arlington, TX
11:30 a.m. 392. Antimicrobial Peptide Kills Bacteria but Presents Low Toxicity toward Human Cells, B. Li*, Q. Wang, West Virginia University, Morgantown, WV
11:45 a.m. 393. Evaluation of Tribocorrosion Kinetics and Biocompatibility of Electrochemically Induced Tribolayer for Hip Implants, M. E. Lyvers*(1), D. Bijukumar(1), A. Moore(2), P. Saborio(3), D. Royhman(1), M. Wimmer(3), K. Shull(4), M. T. Mathew(1), (1)University of Illinois College of Medicine at Rockford, Rockford, IL, (2)Winnebago High School, Winnebago, IL, (3)Rush University
12:00 noon 394. Novel Porous Fully Resorbable Calcium Phosphate Microspheres for Orthobiologic Applications, I. Ahmed*, U. Patel, Z. Hossain, V. Sottile, B. Scammell, University of Nottingham, Nottingham, United Kingdom

Invited Speaker(s)

Thomas Webster, PhD

Active Wound Dressings for Advanced Wound Care

About

Active Wound Dressings for Advanced Wound Care: Although some biologically active compounds were present in ancient naturally-derived poultices, these dressings mainly provided for protection of the wound bed and exudate absorption. With the emergence of cotton fabric (late 1800’s) and synthetics (1950s), these materials became prevalent in wound treatment; however the dressings were still passive, with mainly protective, absorptive, and non-adherent functions. Research into dressings comprised of alloplastic materials which provided a more-active role in wound healing didn’t begin in earnest until the 1960s, and this still remains an under-explored area today.
Challenging requirements such as rapid hemostasis, wound debridement, exudate management, prevention/management of biofilm infection and chronic wounds, pain suppression as well as patient comfort present unique opportunities for the use of modern Biomaterials and textile structures to develop active wound dressings. This session focuses on the recent developments in various aspects of advanced wound care as well as novel materials and structures for wound dressings.

Abstracts

10:15 a.m. 395. Invited Speaker: Garth James, PhD
10:45 a.m. 397. A Novel Dual-Cell Therapy for Chronic Wounds, A. Aijaz*, M. Teryek, R. Olabisi, Rutgers University, Piscataway, NJ
11:00 a.m. 398. Minocycline enhances the mesenchymal stromal/stem cell pro-healing phenotype in triple antimicrobial-loaded hydrogels for inoculated cutaneous wound healing, A. Guerra*, W. Rose, P. Hematti, W. Kao, University of Wisconsin-Madison, Madison, WI
11:15 a.m. 399. Gold Nanosphere Microgel Composites: Biomimetic and Antimicrobial, E. P. Sproul*, S. Sivadanam, B. J. Igo, A. C. Brown, North Carolina State University and The University of North Carolina at Chapel Hill, Raleigh, NC
11:30 a.m. 400. On-demand Dissolution of a Hydrogel Burn Dressing for Facile and Pain-Free Dressing Changes, M. Grinstaff*, Boston University, Boston, MA
11:45 a.m. 401. A Highly Elastic and Antimicrobial Composite Hydrogel-Based Dressing for Wound Healing, D. Rana(1), R. Portillo Lara*(1), E. Shirzaei Sani(1), S. Mithieux(2), A. Weiss(1), N. Annabi(1), (1)Northeastern University, Boston, MA, (2)The University of Sydney, Sydney, Australia
12:00 noon 402. Bioinspired collagen-targeting adhesive hydrogel for scarless skin regeneration, H. J. Cha*, B.-H. Choi*, POSTECH, Pohang, Republic of Korea

Invited Speaker(s)

Garth James, PhD

Biomaterials for Cardiovascular Regeneration

About

Biomaterials for Cardiovascular Regeneration: Cardiovascular disease (CVD) is a major medical problem around the globe. To develop proper treatment strategies for CVD, we must overcome the limitations associated with the i) inability to vascularize synthetic tissues, ii) lack of a renewable cell source, iii), lack of biomaterials that have similar features to the native cardiovascular tissues, and iv) lack of tissue models that can recapitulate the events that occur during cardiovascular healing. In this session, we will include topics ranging from strategies of vascularization of engineered constructs to delivery of small molecules and/or cells, and different fabrication methods for generation of 3D scaffolds. Furthermore, the session will provide examples of using engineered heart tissues to test drugs and therapeutic targets for cardiovascular regeneration. Finally, we will also cover examples for translation of cardiovascular tissue engineering.

Abstracts

10:15 a.m. 403. Invited Speaker: Adam Engler, PhD
10:45 a.m. 405. Microengineered biomimetic blood vessels: revascularizing the infarcted heart, T. Su*, M. Daniele, K. Huang, T. Hensley, A. Young, J. Tang, T. Allen, A. Vandergriff, P. Erb, F. S. Ligler, K. Cheng, North Carolina State University, Raleigh, NC
11:00 a.m. 406. First-Order Mapping of Epicardial Elastin Network in Porcine Hearts, X. Shi(1), K. Copeland(2), B. Brazile(1), Y. Hong(2), P. Bajona(3), S. Zhang(1), J. Liao*(2), (1)Mississippi State University, Mississippi State, MS, (2)University of Texas at Arlington, Arlington, TX, (3)University of Texas Southwestern Medical Center, D
11:15 a.m. 407. Novel Nanomatrix Reduces Inflammation in Dynamic Conditions in Vitro and Dilates Arteries ex Vivo, G. Alexander*(1), J. Vines(1), P. Hwang(1), T. Kim(1), J.-A. Kim(1), B. Brott(1), Y.-S. Yoon(2), H.-W. Jun(1), (1)University of Alabama at Birmingham, Birmingham, AL, (2)Emory University, Atlanta, GA
11:30 a.m. 408. Antibody-Based Targeting of Elastic Matrix Regenerative Nanoparticles to Aortic Aneurysms, J. Fox*, A. Ramamurthi, The Cleveland Clinic, Cleveland, OH
11:45 a.m. 409. Isolating rare cells through antigen specific hydrogel encapsulation, A. Gottipati*, L. Chelvarajan, A. Abdel-Latif, B. J. Berron, University of Kentucky, Lexington, KY
12:00 noon 410. Bioengineering of Cardiac Tissue Constructs with Adult Cardiomyocytes, Z.-W. Tao*(1), R. Birla(2), J. G. Jacot(1), (1)University of Colorado Denver / Anschutz Medical Campus, Aurora, CO, (2)University of Houston, Houston, TX

Invited Speaker(s)

Adam Engler, PhD

Engineered Biomaterials for Neural Applications 2

About

Engineered biomaterials for neural applications: Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.

Abstracts

10:15 a.m. 411. The Effect of Peptide Affinity in Neural Stem Cell Mechanosensing, J. Stukel*, R. K. Willits, University of Akron, Akron, OH
10:30 a.m. 412. An Intraocular Drug Delivery System Using Targeted Nanocarriers Attenuates Retinal Ganglion Cell Degeneration, G. Chen, L. Zhao, Y. Fu, T. Mavlyutov, A. Yao, R. W. Nickells, L.-W. Guo, S. Gong*, UW-Madison, Madison, WI
10:45 a.m. 413. Combining Human Induced Pluripotent Stem Cell-Derived Neuronal Grafts with Local Delivery of Chondroitinase ABC for Treatment of Spinal Cord Injury, T. Fuehrmann*(1), P. N. Anandakumaran(1), S. L. Payne(1), M. Pakulska(1), B. Varga(2), A. Nagy(2), C. Tator(3), M. S. Shoichet(1), (1)University of Toronto, Toronto, ON, (2)Mount Sinai Hospital, Toronto, ON, (3)University Health Network, Toronto, ON
11:00 a.m. 414. Blended polyester nanoparticles to modulate retinoid signaling in a transgenic murine model of ALS, D. X. Medina*, E. P. Chung, R. Ceton, R. P. Bowser, R. W. Sirianni, Barrow Brain Tumor Research Center, Phoenix, AZ
11:15 a.m. 415. Enhancing Peripheral Nerve Regeneration through Nanofibers, Microspheres and Physical Therapy, H. g. Sundararaghavan*, T. J. Whitehead, J. Peduzzi, A. Mazhari, C. Chen, J. Cavanaugh, Wayne State University, Detroit, MI
11:30 a.m. 416. Release Profile of Exogenous SDF-1 Differentially Affects Cortical SDF-1/CXCR4 Signaling In Vivo, D. Dutta*, C. Willingham, C. Fauer, K. Hickey, S. E. Stabenfeldt, Arizona State University, Tempe, AZ
11:45 a.m. 417. Magnetic Alignment of Electrospun Poly-l lactic acid Fibers for Directed Cell Guidance after Spinal Cord Injury, D. Ganguly(1), S. McCarthy(1), S. Dutz(2), R. Gilbert(1), (1)Rensselaer Polytechnic Institute, Troy, NY, (2)Technische Universität Ilmenau, Ilmenau, Germany
12:00 noon 418. Mechanically-tunable Extracellular Matrix Hydrogel Scaffold for Use in a Tissue-Engineered Electronic Nerve Interface (TEENI), B. S. Spearman*, R. A. Wachs, V. H. Desai, C. S. Shafor, J. B. Graham, E. W. Atkinson, E. A. Nunamaker, K. J. Otto, C. E. Schmidt, J. W. Judy, University of Florida, Gainesville, FL

Evaluation of Tissue Engineering Constructs

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Evaluation of Tissue Engineering Constructs: Tissue engineering is a multi-disciplinary and growing field of research that involves the development of new biomaterials, cell sources, and advanced drug/factor delivery strategies for the repair and regeneration of lost or damaged tissues and organs. This session will cover the development of new methods to rapidly and effectively evaluate the performance of tissue engineering strategies and constructs in laboratory and pre-clinical settings. Specific areas to be covered include the development and testing of new biological assays, bioreactors, in vitro and in vivo models, organs-on-a-chip, advanced imaging methodologies, and non-invasive tools for in situ monitoring of cell and tissue activity.

Abstracts

10:15 a.m. 419. Invited Speaker: Yusuf Khan, PhD
10:45 a.m. 421. Evaluation of Biodegradable Hydrogels in a Femoral Bone Plug Model, P. Fisher(1), B. Orellana(1), A. Clark(1), C. Exposto(1), S. Huja(1), T. Milbrandt(2), D. Puleo*(1), (1)University of Kentucky, Lexington, KY, (2)Mayo Clinic, Rochester, MN
11:00 a.m. 422. Controlled BMP2 Release from Keratin-based Hydrogels Modulates Osteoinduction, S. L. Hyzy*(1), J. M. Saul(2), D. J. Cohen(1), I. Kajan(1), L. Olson(1), Z. Schwartz(1), B. D. Boyan(1), (1)Virginia Commonwealth University, Richmond, VA, (2)Miami University, Oxford, OH
11:15 a.m. 423. Design, Fabrication, and Characterization of Microscale Bicuspid Valves 3D Printed in Biocompatible Hydrogels, S. J. Paulsen*, B. Grigoryan, J. S. Miller, Rice University, Houston, TX
11:30 a.m. 424. Cytocompatibility of Hafnium Oxide (HfO2) Nanoparticles for Diagnostic Imaging and Sensing, T. L. McGinnity*(1), V. Sokolova(2), P. D. Nallathamby(1), O. Prymak(2), M. Epple(2), R. K. Roeder(1), (1)University of Notre Dame, Notre Dame, IN, (2)University of Duisburg Essen, Essen, Germany
11:45 a.m. 425. Investigating Oxygen Dynamics of Stem Cells in a Mineralized Osteogenic Scaffold, M. Kotecha*(1), S. Ravindran(1), B. Epel(2), H. Halpern(2), (1)University of Illinois at Chicago, Chicago, IL, (2)The University of Chicago, Chicago, IL
12:00 noon 426. Non-Invasive Fracture Property Analysis of Lumbar Vertebrae Affected by Osteoporosis, M. L. Oppenheimer-Velez*, H. Giambini, S. Khosla, M. J. Yaszemski, L. Lu, Mayo Clinic, Rochester, MN

Invited Speaker(s)

Yusuf Khan, PhD

Panel Discussion: Veterinary Bioengineering: Partnering with Clinicians to Translate Biomaterials Technologies

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Lynne Jones, MS, PhD (Moderator)
This panel discussion will provide discourse regarding the application of bioengineering to veterinary medicine, specifically addressing technical goals as well as collaboration challenges and opportunities. The value of clinical-bioengineering collaborations to the classroom setting will also be highlighted. Differences in technical “culture”, expectations, and motivators will be explored in conjunction with discussion of best (and worst!) practices in working across clinical-engineering boundaries. Topics will include animal studies used to characterize the biological response to materials for translation to human medicine as well as for application to animal health. Two collaborating engineer-veterinary clinician teams will overview and discuss their experiences in large and small animal research, including classroom, clinical, and laboratory; the audience is encouraged to participate in lively and frank discussion.

Injectable Biomaterials for Delivery of Cell, Gene and Protein Therapy

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Abstracts

BTI Translational Orthopaedic Biomaterials

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Abstracts

Invited Speaker(s)

Active Wound Dressings for Advanced Wound Care

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Abstracts

Invited Speaker(s)

Biomaterials for Cardiovascular Regeneration

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Abstracts

Invited Speaker(s)

Engineered Biomaterials for Neural Applications 2

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Abstracts

Evaluation of Tissue Engineering Constructs

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Abstracts

Invited Speaker(s)

Panel Discussion: Veterinary Bioengineering: Partnering with Clinicians to Translate Biomaterials Technologies

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Abstracts

Invited Speaker(s)

Tutorial: Navigating funding from the NSF & NIH

Abstracts

Invited Speaker(s)