Biomaterials Education SIG

600. An Exploration of Faculty Perceptions of Tissue Engineering and Regenerative Medicine to Inform Biomedical Engineering Curriculum Development, N. Friend*, C. Woodcock, J. Stegemann, A. Huang-Saad; University of Michigan, Ann Arbor, MI, USA

601. Biomaterials Experiential Learning: Integrating Research and Professional Development, K. Burg*, T. Burg; University of Georgia, Athens, GA, USA

Biomaterial-Tissue Interaction SIG

602. Assessment of the Osteopromotive Potential of a Novel Biocompatible Mineral-Organic Adhesive Bone Cement in the Microgravity of Space and on Earth., J. Willoughby, Sr.*(1), M. Brown(2), R. Jadia(2), B. Ebendick-Corpus(1), N. Hibbard(1), J. McKim(1), B. Hess(2); (1)IONTOX, LLC, Kalamazoo, MI, USA, (2)LaunchPad Medical, LLC, Lowell, MA, USA

603. Keratin Nanomaterial Coating Limits Epithelial Downgrowth Around Percutaneous Devices, B. Bennett*(1,2), S. Jeyapalina(1,2), J. Beck(2), K. Bachus(2), M. Van Dyke(3), A. Trent(3); (1)University of Utah, SALT LAKE CITY, UT, USA, (2)Department of Veterans Affairs, Salt Lake City, UT, USA, (3)Virginia Tech, Blacksburg, VA, USA

604. Engineering Autoclavable and Injectable Hyaluronic Acid-Based Cryogel Scaffolds, M. Rezaeeyazdi*(1), T. Colombani(1), S. Bencherif(1,2,3); (1)Northeastern University, Boston, MA, USA, (2)Harvard University, Cambridge, MA, USA, (3)Sorbonne University, Paris, France

605. Using Feature Datasets of Nanoparticle Diffusion to Predict Parameters of the Brain Microenvironment, C. Curtis*, M. McKenna, E. Nance; University of Washington, Seattle, WA, USA

606. The Effect of Annealing and Surface Texture Of 3D Printed PEEK on MC3T3 E1 Behavior, C. Basgul*(1), T. Yu(1), S. Escobedo(1), D. MacDonald(1), M. Marcolongo(1), S. Kurtz(1,2); (1)Drexel University, Philadelphia, PA, USA, (2)Exponent Inc., Philadelphia, PA, USA

607. Characterizing Tissue Deformation and Inflammation Due to Convection Enhanced Delivery in the Brain, M. Dessi*, S. Kodamasimham, C. Wood, J. Sy; Rutgers University, Piscataway, NJ, USA

608. Designing Polymers for the Activation of, and Selective Resorption by, Osteoclasts for Bone Regeneration, S. Fung*(1), D. Martin(2), A. Mahat(1), P. Mishra(2), J. Cohen(1), E. Pashuck(1), Y. Mao(1), P. Moghe(2), A. Merolli(1), J. Kohn(1); (1)New Jersey Center for Biomaterials, Rutgers University, The State University of New Jersey, Piscataway, NJ, USA, (2)Rutgers University, The State University of New Jersey, Piscataway, NJ, USA

609. Contribution of Scaffold Crosslinking and Pro-inflammatory Signals to Vascularization in vivo, A. Clark*, K. Spiller; Drexel University, Philadelphia, PA, USA

610. Interactions of Dermal Papilla Spheroid Array and Acellular Skin Dermis During Hair Follicle Regeneration, Y.-Y. Huang*; National Taiwan University, Taipei, Taiwan

611. Increased Nanoparticle Uptake Under Disturbed Flow-Induced Degraded Glycocalyx Conditions, N. Bal*, M. Cheng, R. Kumar, S. Sridhar, E. Ebong; Northeastern University, Boston, MA, USA

612. Cross-linked Electrospun Cartilage Acellular Matrix Film as an Anti-Adhesive Barrier, M.S. Kim*, J.Y. Park; Ajou University, Suwon, Republic of Korea

Biomaterials for Cardiovascular Regeneration

613. Bioprinted Cardiac Patch Composed of Cardiac Progenitor Cells and Extracellular Matrix for Heart Repair and Regeneration, D. Bejleri*(1), B. Streeter(1), A. Nachlas(1), M. Brown(1), R. Gaetani(2), K. Christman(2), M. Davis(1); (1)Georgia Institute of Technology and Emory University, Atlanta, GA, USA, (2)University of California, San Diego, La Jolla, CA, USA

614. Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic, E. Mihalko*(1,2), K. Huang(2,3), E. Sproul(1,2), K. Cheng(1,2,3), A. Brown(1,2); (1)North Carolina State University and the University of North Carolina at Chapel Hill, Raleigh, NC, USA, (2)North Carolina State University, Raleigh, NC, USA, (3)NC State University, Raleigh, NC, USA

615. ROS Scavenging Thermoresponsive Hydrogels Improves Contractility in Ovine Myocardium Adjacent to a Myocardial Infarction, Y. Zhu*(1), K. Spaulding(2), A. Ramasubramanian(1), A. Badathala(2), D. Lovett(2), A. Baker(2), N. Ziats(3), K. Healy(1), M. Ratcliffe(2), H. Haraldsson(2); (1)University of California, Berkeley, Berkeley, CA, USA, (2)Veterans Affairs Medical Center, San Francisco, CA, USA, (3)Case Western Reserve University, Cleveland, OH, USA

616. Polyhydroxyalkanoates, Ideal Materials for Cardiac Regeneration, I. Roy*(1), P. Dubey(1), E. Humphrey(2), Q. Majid(2), C. Grigsby(3), M. Stevens(3,4), C. Terracciano(2), S. Harding(2); (1)University of Westminster, London, United Kingdom, (2)Imperial College London, London, United Kingdom, (3)Karolinska Institutet, Stockholm, Sweden, (4)Imperial College, London, United Kingdom

617. Substrate Stiffness Modulates Endothelial-to-Mesenchymal Transition, N. Huang*, M. Zamani, F. Charbonier; Stanford University, Stanford, CA, USA

618. Evaluating Pre-vascularized Microtissues in a Mouse Model of Critical Limb Ischemia, N. Friend*, J. Beamish, J. Stegemann, A. Putnam; University of Michigan, Ann Arbor, MI, USA

619. Riboflavin Photocrosslinking Method for Improving Elastin Stability and Reducing Calcification in Bioprosthetic Heart Valves, Y. Lei*, W. Jin, G. Guo, M. Liu, Y. Wang; Sichuan University, Chengdu, China

620. Autologous Vascular Regeneration for Peripheral Artery Disease with Induced Pluripotent Stem Cells, B. Jiang*, Y. Zhu, X. Wang, N. Rivera Bolanos, C. Duan, X. Zhang, G. Ameer; Northwestern University, Evanston, IL, USA

621. Hypoxia-sensitive Oxygen Release Microspheres to Improve Cell Survival under Ischemic Conditions, Y. Guan*, N. Gao, H. Niu, Y. Dang, J. Guan; Washington University in St. Louis, St. Louis, MO, USA

622. Cardiac Stromal Cell / Platelet-Inspired Nanoparticles for Targeted Heart Repair, T. Su*(1,2), K. Huang(1,2), P.-U. Dinh(2), J. Cores(1,2), Z. Li(1,2), S. Hu(1,2), Q. Yin(2), F. Ligler(1), K. Cheng(1,2); (1)University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA, (2)North Carolina State University, Raleigh, NC, USA

623. An ECM-mimicking Bilayer Vascular Graft from Collagen Filaments and Nanofibers, F. Zhang*(1), S. Bernacki(2), O. Okkus(3), M. King(1,4); (1)North Carolina State University, Raleigh, NC, USA, (2)UNC & NC State University, Raleigh, NC, USA, (3)Case Western Reserve University, Cleveland, OH, USA, (4)Donghua University, Shanghai, China

624. Increasing Cardiomyocyte Alignment Through Micropatterning in the Tension-Culture Composite Cardiac Patch, E. English*, G. Pins; Worcester Polytechnic Institute, Worcester, MA, USA

625. Antibody and Synthetic Peptide-Based Smart Targeting of Matrix Regenerative Nanoparticles for Aortal Wall Repair, A. Camardo*(1), A. Ramamurthi(1,2); (1)Cleveland Clinic, Cleveland, OH, USA, (2)Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

626. Characteristics Required for Ultra Small-Diameter (0.6mmID) Acellular Blood Vessels: Differences from Small-Diameter (2mmID) Ones, T. Yamaoka*(1), H. Yamanaka(1,2); (1)National Cerebral and Cardiovascular Center, Suita, Japan, (2)Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan

627. Small Caliber Silk Fibroin Vascular Graft: from Design to in vitro and in vivo Tests, U. Armato*(1), A. Alessandrino(2), A. Chiarini(1), M. Biagiotti(2), G. Bassani(2), V. Vincoli(2), I. Dal Pra(1), G. Freddi(2); (1)University of Verona Medical School, Verona, Italy, (2)Silk Biomaterials Srl, Lomazzo (Co), Italy

628. Injectable Decellularized Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model, M. Diaz*(1,2), R. Gaetani(1,2), C. Luo(3), R. Braden(1,2), A. DeMaria(3), K. Christman(1,2); (1)University of California, San Diego, La Jolla, CA, USA, (2)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA, (3)University of California San Diego, La Jolla, CA, USA

629. Formation of Cardiac Tissues from Encapsulated hiPSCs through LAP-initiated Photocrosslinking, F. Finklea*, G. Bradley, E. Lipke; Auburn University, Auburn University, AL, USA

630. A Transparent and Long-Lasting Fibrin Hydrogel for Dynamic Cell Culture and Tissue Engineering, D. Jarrell*, E. Vanderslice, M. Lennon, J. Jacot; University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA

631. The Effect of Decellularization Method on Cell Behavior on the Decellularized Aorta, M. Kobayashi*(1), M. Kondo(1), A. Tamura(1), Y. Hashimoto(1), T. Fujisato(2), T. Kimura(1), A. Kishida(1); (1)Tokyo Medical and Dental University, Tokyo, Japan, (2)Osaka Institute of Technology, Osaka, Japan

632. Increasing Pore Size for Prevascularizing Electrospun Cardiac Patches, E. Beck*, A. Lyons, J. Jacot; University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA

633. Mechano-environment Modulates Matrix Hydrogel Induced Cardiomyocyte Cell Cycle Activity in Cardiac Explants, X. Wang*, S. Senyo; Case Western Reserve University, Cleveland, OH, USA

634. Plasma-modification of PVDF Scaffolds improve Cardiomyocytes Viability and Morphology, M. Kitsara*(1), T. Dufour(2), V. Humblot(3), M. Legris(1), A. Simon(1), G. Revet(1), O. Agbulut(1); (1)Sorbonne Université, IBPS, Paris, France, (2)Sorbonne Université, LPP, Paris, France, (3)Sorbonne Université, Department of Chemistry, Paris, France

635. Injectable Hydrogel Delivery of Extracellular Vesicles Isolated from Pre-Conditioned Cells to the Heart, M. Chen*(1), E. Li(2), A. Gaffey(2), D. Goldberg(2), S. Kim(2), Z. Tran(2), P. Atluri(2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Cardiovascular Biomaterials and Blood Compatibility

636. Electrospun Bilayer Fibrous Membranes of Polycaprolactone (PCL)-Collagen/Silica for Small Diameter Vascular Prostheses, S. Park*(1), M. Lee(1), J. Kim(1), C. Hwang(1), H.-E. Kim(1), T.-S. Jang(2); (1)Seoul National University, Seoul, Republic of Korea, (2)Liquid Processing & Casting Technology R&D Group, Korea Institute of Industrial Technology, Incheon, Republic of Korea

637. Particular Ratios of Blended, Electrospun Scaffolds Impact Molecular Orientation and Reduce Collagen Thrombogenicity, K. Washington*, P. Dewan, K. Clarke, M. Shojaee, C. Bashur; Florida Institute of Technology, Melbourne, FL, USA

638. Synergistic Effects of Functional Additives on the Physico-Mechanical and Biological Properties of Poly(L-lactic acid) Composites for Cardiovascular Implant Applications, D.K. Han*(1), E.Y. Kang(1,2), B. Choi(1), W. Park(1), I.H. Kim(2); (1)CHA University, Seongnama-si, Republic of Korea, (2)Korea University, Seoul, Republic of Korea

639. Hemocompatibility of Superhydrophobic and Superhydrophilic Surfaces, R. Maia Sabino*, T. Kumar Jammu, H. Vahabi, S. Movafaghi, A. Kota, K. Popat; Colorado State University, Fort Collins, CO, USA

640. Plasma Treated TiO2 Nanotubular Surfaces as Stents - Interactions with Biological Materials, M. Benčina*(1), I. Junkar(1), A. Iglič(2), K. Lakota(3), M. Mozetič(1), S. Sodin-Šemrl(3); (1)Jozef Stefan Institute, Ljubljana, Slovenia, (2)Faculty of Electrical Engineering, Ljubljana, Slovenia, (3)University Medical Centre Ljubljana, Ljubljana, Slovenia

641. In situ Generation of Nitric Oxide from Heparinized Surfaces for Enhanced Cardiovascular Therapy, L. Tran*, K.D. Park, P. Le; Ajou University, Suwon, Republic of Korea

642. A Coronary Drug-Eluting Stent Functionalized with Magnesium Hydroxide on Abluminal Layer for Improving Re-endothelialization with a Minimalized Inflammatory Response, W. Park*, D.-W. Jeong, D.K. Han; CHA University, Seongnam-si, Republic of Korea

643. Thrombogenicity of Poly(vinyl) Alcohol Hydrogels is Dependent on the Crosslinking Agent, N. Bates*, C. Puy, O. McCarty, M. Hinds; Oregon Health & Science University, Portland, OR, USA

Cardiovascular Biomaterials SIG

644. Characterizing the Long Term Inflammatory Response to Zinc Stent Materials, A. Oliver*(1), E. Earley(1), R. Guillory, II(1), J. Drelich(2), J. Goldman(1); (1)Michigan Technological University, Houghton, MI, USA, (2)Michigan Tech University, Houghton, MI, USA

645. Corrosion Behavior of HF-treated Mg Alloy Scaffold After Expansion, X. Wei*(1), Y. Kai(1), K. Yuki(2), S. Makoto(2), N. Takuro(1); (1)Kumamoto University, Kumamoto, Japan, (2)Japan Medical Device Technology Co., Lyd, Kumamoto, Japan

646. Zn2+ Release from Intravascular Metallic Zinc Implants Promote Smooth Muscle Cells Apoptosis, R. Guillory, II*, J. Goldman; Michigan Technological University, Houghton, MI, USA

647. A Paradigm-Shifting Stent Technology: Liquid Cast Arterial Stents, W. He*, H. Kassam, M. Klein, N. Tsihlis, M. Kibbe; University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

648. Long Term Biocompatibility of Zn and Zn Alloys in a Murine Arterial Model, E. Earley*(1), R. Guillory, II(1), A. Oliver(1), J. Goldman(1), J. Drelich(2); (1)Michigan Technological University, Houghton, MI, USA, (2)Michigan Tech University, Houghton, MI, USA

649. Vessel Graft Fabricated by the Onsite Differentiation of Mesenchymal Stem Cells in the Vascular Extracellular Matrix Scaffold Under Mechanical Stimulation in Bioreactor, Z. Hong*, N. Li; University of South Dakota, Sioux Falls, SD, USA

650. Inexpensive Method for Measuring Mechanical Properties of Polymeric Biomaterials, S. Tasmim*, N. Bodiford, J. Coffer, T. Tayag; Texas Christian University, Fort Worth, TX, USA

651. Hydrogels with self-healing abilities as injectable carriers for vasculogenesis, Z. Wei*, S. Gerecht; The Institute for NanoBioTechnology, Baltimore, MD, USA

652. A Biodegradable Knitted Heart Cap for the Delivery of Cardiosphere-Derived Cells (CDCs) to Induce Reverse Remodeling of a Failing Left Ventricle, J. Chen*(1), K. Cheng(2), A. West(1), M. Daneshmand(3), M. King(1); (1)North Carolina State University, Raleigh, NC, USA, (2)Veterinary School, North Carolina State University, Raleigh, NC, USA, (3)Duke University Medical Center, Durham, NC, USA

653. Fibrotic and Calcific Roles of TNF-a on Valvular Interstitial Cells Encapsulated within 3D MMP-degradable Hydrogels, A. Gonzalez Rodriguez*(1,2), M. Schroeder(1,2), K. Anseth(1,2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

654. Examining the Signaling Pathways Connecting Endothelial-Mesenchymal Transition (EndMT) and Smooth Muscle Cells in Vascular Calcification, C. Travis*, C. Roach, C.L. Simpson; Mississippi State University, Mississippi State, MS, USA

655. Design and development of stent coated with novel cardiac stem cell-mimicking regenerative factors, M. King*(1,2), T. Bambharoliya(1), S. Hu(3,4), K. Cheng(3,4); (1)NC State University, Raleigh, NC, USA, (2)Donghua University, Shanghai, China, (3)North Carolina State University, Raleigh, NC, USA, (4)University of North Carolina Chapel Hill & North Carolina State University, Chapel Hill, NC, USA

Dental/Craniofacial Biomaterials SIG

656. Si3N4 or UHMWPE a Potential Material for Fabricating TMJ Condylar Prosthesis?, S.K. Mamidi*(1), M. T Mathew(1), V. A R Barao(2), N. Gurram(3), M. Louis G(4); (1)University of Illinois at Chicago, College of Medicine, Rockford, IL, USA, (2)University of Campinas, Campinas, Brazil, (3)CAE Consultant, Secunderabad, India, (4)TMJ Concepts, Ventura, CA, USA

657. A Pilot Study on the Structural Role of Water in Dental Tissues, E. Sobiesk*(2), J. Livingston(1), Y. Duan(2), S. Yang(3); (1)Mississippi State University, Mississippi State, MS, USA, (2)University of Mississippi Medical Center, Jackson, MS, USA, (3)Jackson State University, Jackson, MS, USA

658. Relaxin as an Enhancer of BMP-2 Loaded Hydroxyapatite Microspheres in Bone Regeneration, Y.-W. Huang*, S. Injamuri, M. Rahaman, Y. Shen; Missouri University of Science and Technology, Rolla, MO, USA

659. Mineralized Short Nanofibers Coupled with BMP-2 Peptides for Alveolar Bone Regeneration, J. Xie*, H. Wang, S. Boda; University of Nebraska Medical Center, Omaha, NE, USA

660. Determination of Phase Evolution of a Novel Mineral-Organic Bone Adhesive in vivo and in vitro, R. Jadia*, G. Kay, M. Brown, C. Cavaleri, R. Shea, B. Hess; LaunchPad Medical, LLC, Lowell, MA, USA

661. Enhancing Vital Bone Growth With Growth Enhancers - L-PRF and Calcium Sulfate, R. Horowitz*; NYU College of Dentistry, NY, NY, USA

662. Bioactive Materials for Dentoalveolar Reconstruction and Regeneration, R. Horowitz*; NYU College of Dentistry, NY, NY, USA

663. Color Changes of Resins Applied in the Fabrication of 3D-Printed Orthodontic Brackets, F. Kasper*, A. Haynie, M. Abu Al Tamn, J. English, R. Paravina; The University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA

664. Highly Efficient Labeling of Mesenchymal Stem Cells with Superparamagnetic MRI probes in Magnetic Field, J. Duan*(1), R. Jin(1), L. Liu(1), L. Yang(1), H. Ai(1,2); (1)National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, (2)Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

665. Silicon-Containing Shape Memory Polymer (SMP) Scaffolds for Cranial Bone Defect Repair, F. Beltran*, M. Grunlan, C. Houk; Texas A&M University, College Station, TX, USA

666. Synthetic Morphogen Fields for Directed Dental Pulp Stem Cell Differentiation, S. Rahman*, M. Nagrath, S. Ponnusamy, P. Arany; University at Buffalo, Buffalo, NY, USA

667. Functionalization of Dental Prosthetic Interfaces Following Adaption of Dental Materials for 3D Printing, A. Sikora*, M. Nagrath, J. Graca, S. Ur Rahman, P. Arany; University at Buffalo School of Dental Medicine, Buffalo, NY, USA

668. Smart Dental Fillings with Ruthenium Nanoparticles-enhanced Photobiomodulation Therapy for Pulp-Dentin Regeneration, N. Young*(1), R. Mosca(1,2), P. Arany(1), C. Zeituni(2); (1)University at Buffalo, Buffalo, NY, USA, (2)Energetic and Nuclear Research Institute (IPEN/CNEN-SP)-CTR, Sao Paulo, Brazil

Guided Tissue Regeneration

669. A Modular Host-Gust Approach to Build up Glycopolymers for Cell Surface Engineering, Y. Gu*, B. Liu, G. Chen, H. Chen; Soochow University, Suzhou, China

670. Electrospun Chitosan Guided Bone Regeneration Membranes for Delivery of Simvastatin to Stimulate Osteogenesis, V.P. Murali*, F. Guerra, T. Fujiwara, J. Bumgardner; University of Memphis, Memphis, TN, USA

671. Electrospun Chitosan Membranes Loaded with Raspberry Ketone for Guided Bone Regeneration Applications, P. Cameron*, V. Murali, F. Delbuque Guerra, J. Bumgardner; University of Memphis, Memphis, TN, USA

672. Effect of a Polymer/Ceramic Membrane Associated with Mesenchymal Stem Cells on Bone Repair in Osteoporotic Rats, A. Souza*(1), A. Almeida(1), G. Freitas(1), H. Lopes(1), R. Gimenes(2), S. Siessere(1), L. Sousa(1), M. Beloti(1), A. Rosa(1); (1)University of São Paulo, Ribeirão Preto, Brazil, (2)Federal University of Itajubá, Itajubá, Brazil

Biomaterials for Therapeutic Drug Delivery

673. Macrophage-Targeted Antibacterial Polymeric Prodrug for Controlled Drug Pharmacokinetics Against Alveolar Pulmonary Intracellular Infections, D. Roy*(1), F.-Y. Su(1), S. Srinivasan(1), B. Lee(2), T. West(2), D. Ratner(1), S. Skerrett(2), P. Stayton(1); (1)University of Washington, Seattle, WA, USA, (2)Harborview Medical Center, University of Washington, Seattle, WA, USA

674. Glomerular Disease Augments Kidney Accumulation of Synthetic Anionic Polymers, A. Prossnitz*, G. Liu, D. Eng, Y. Cheng, J. Pippin, R. Lamm, C. Ngambenjawong, R. Jain, S. Shankland, S. Pun; University of Washington, Seattle, WA, USA

675. Drug-Refillable In Situ Forming Implants for Recurrent Tumor Chemotherapy, A. Dogan*, K. Young, H. von Recum; Case Western Reserve University, Cleveland, OH, USA

676. Rm-loaded Polymeric Micelles Reduces Secondary Injury in a Rat TBI Model, C. Macks*(1), D. Jeong(1), M. Lynn(2), J. Lee(1); (1)Clemson University, Clemson, SC, USA, (2)Greenville Hospital System, Greenville, SC, USA

677. N-Oxalylglycine-Conjugated Hyaluronic Acid Stimulates Angiogenic Gene Expression, A. DeMaria*, K. Webb, J.S. Lee; Clemson University, Clemson, SC, USA

678. Promotion of Accelerated Healing in a Mouse Wound Model with a Viral Immunomodulator Serp-1/chitosan Gel, L. Zhang*, J. Yaron, S. Wallace, M. Burgin, A. Tafoya, A. Lucas; Arizona State University-Tempe, Tempe, AZ, USA

679. Targeted Drug Delivery via Cell-Nanoparticle Hybridization for Enhanced Efficacy and Reduced Off-Target Toxicity, R. Cooper*(1), J. Wang(2), H. Yang(2,3,4); (1)Virginia Commonwealth University, College of Engineering, Richmond, VA, USA, (2)Virginia Commonwealth University; College of Engineering, Richmond, VA, USA, (3)Virginia Commonwealth University, School of Pharmacy, Richmond, VA, USA, (4)Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA

680. Localized Tacrolimus Delivery for Transplant Rejection Prevention via TyroSphere-loaded Rapidly Soluble Films, J. Molde*(1), A. Merolli(1), J. Steele(1), M. Lima(1), S. Pratts(2), A. Lellouch(2), C. Cetrulo, Jr.(2), J. Kohn(1); (1)New Jersey Center for Biomaterials, Rutgers - The State University, Piscataway, NJ, USA, (2)Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, USA

681. Antibiotic Extended Release Concentration Quantification By Semi-empirical Model For Insulin Delivery Catheters, J. King*, B. Ratner; University of Washington, Seattle, WA, USA

682. Anti-VEGF Delivery from Alginate – Chitosan Polyelectrolyte Complexes Decreases Bony Bar Formation in Physeal Injuries, J. Newsom*(1), C. Erickson(2), N. Fletcher(1), Z. Feuer(2), Y. Yu(2), F. Fontan(2), N. Miller(2), K. Payne(2), M. Krebs(1); (1)Colorado School of Mines, Golden, CO, USA, (2)CU Denver, Aurora, CO, USA

683. Hollow Microshell Through Layer-by-Layer Self-Assembly of Natural Polyelectrolytes on E. coli, M. Yitayew*, M. Tabrizian; McGill University, Montreal, QC, Canada

684. Polyzwitterion Coated Peptide Dendritic Carbon Dots for Efficient Chemotherapy, Q. Yi*, J. Ma, Z. Gu; Sichuan University, Chengdu, China

685. Development of Coacervates Using mPEGylated Poly(Ethylene Arginylaspartate Diglyceride) Cationic Polymer for Protein Delivery, H. Jo*, G. Mani, K. Kim; Incheon National university, Incheon, Republic of Korea

686. Implantable Peptide-Hydrogel Drug Delivery System for Treating Glioblastoma Multiforme, M. Elpers*, A. Gregory, E. Miller, A. Alexander-Bryant; Clemson, University, Clemson, SC, USA

687. Sustained-released Platelet-Rich Plasma from Polyethylene Glycol Hydrogels Exerts Beneficial Effects on Chondrocytes, A. Blanco*(1), E. Jain(2), N. Chinzei(3), N. Case(1), S. Sell(1), M. Rai(3), S. Zustiak(1); (1)Saint Louis University, Saint Louis, MO, USA, (2)Washington University in St. Louis, St. Louis, MO, USA, (3)Washington University School of Medicine, St. Louis, MO, USA

688. 3D Printed Degradable Microneedles for Controlled Drug Release in the Nervous System, M. Walter*, J. Johnson, R. Saigal; University of Washington, Seattle, WA, USA

689. Sustained-Release Depots for HIV PrEP, C. LeGuyader*, D. Roy, S. Srinivasan, P. Stayton; University of Washington, Seattle, WA, USA

690. Polymeric Nanoparticles for Controlled and Systemic Delivery of an Anti-Cancer Chelator, C. Holley*, S. Majd; University of Houston, Houston, TX, USA

691. Fluorescence Correlation Spectroscopy for the Measurement and Prediction of Drug Release from Degradable Hydrogels, S. Sheth*(1), E. Barnard(2), M. Rathinam(2), S. Zustiak(1); (1)Saint Louis University, St. Louis, MO, USA, (2)University of Maryland Baltimore County, Baltimore, MD, USA

692. PLGA-Encapsulated Nanoceria and SOD as a Deliverable, Antioxidative Therapy, A. Mehta*(1), B. Scammon(1), D. Ashley(1), B. Stewart(1), K. Jardim(1), K. Shrake(1), M. Bredikhin(1), V. Ivanov(2), V. Reukov(1); (1)Clemson University, Clemson, SC, USA, (2)Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russian Federation

693. In situ Ethanol Depot Enhances Tumor Necrosis and Immune Activity in Breast Tumors, C. Nief*, R. Morhard, B. Crouch, N. Ramanujam; Duke University, Durham, NC, USA

694. pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases, C. Bartomeu Garcia*, D. Shi, T. Webster; Northeastern University, Boston, MA, USA

695. Target-switchable Modular Bacterial Toxin Delivery System, S. Park*(1), B. Choi(2), Y. Bae(1), S. Kang(1); (1)Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, (2)Northwestern University, Chicago, IL, USA

696. Accelerated Arteriogenesis and Vessel Branching Using Dll4/VEGF Delivery System, H. Niu*(1), N. Gao(2), Y. Dang(2), Y. Guan(2), J. Guan(2); (1)The Ohio State University, Columbus, OH, USA, (2)Washington University in St Louis, St Louis, MO, USA

697. Local Delivery of Hepatocyte Growth Factor Reduces Glial and Fibrotic Scar Formation After Spinal Cord Injury, Y. Zhong*(1), Z. Wang(1), M. Yang(1), J. Nong(1), R. Shultz(1), Y. Zhao(1), S. Hou(2); (1)Drexel University, Philadelphia, PA, USA, (2)Drexel University College of Medicine, Philadelphia, PA, USA

698. ROS-responsive Drug Carriers for Intracellular Delivery of Pro-Oxidant Drugs, M.S. Shim*(1), Y.-S. Kim(1), S. Kim(2), D.G. Choi(1); (1)Incheon National University, Incheon, Republic of Korea, (2)The Catholic University of Korea, Gyeonggi-do, Republic of Korea

699. Liquid Filled Multilayered Capsules for Oral Delivery, Y. Kim*, J. Kim, Y. Kim, J.-H. Jang; Yonsei University, Seoul, Republic of Korea

700. Targeted Delivery of Nanoparticles as a Treatment for Emphysema, V. Parasaram*, X. Wang, N. Vyavahare; Clemson University, Clemson, SC, USA

701. Engineering Poly(lactic-co-glycolic) Acid Nanoparticles to Target the Inflamed Peripheral Nerve, K. Langert*(1,2), E. Brey(3,4); (1)Illinois Institute of Technology, Chicago, IL, USA, (2)Edward Hines, Jr., VA Hospital, Hines, IL, USA, (3)University of Texas at San Antonio, San Antonio, TX, USA, (4)Audie L. Murphy Memorial VA Hospital, San Antonio, TX

702. Sustained Release Silk Foams for the Local Delivery of Monoclonal Antibodies, B. Yavuz*(1), K. Harrington(1), B. Perez-Ramirez(2), P. LiWang(3), D. Kaplan(1); (1)Tufts University, Medford, MA, USA, (2)Sanofi, Framingham, MA, USA, (3)University of California - Merced, Merced, MA, USA

703. Folate-PEG Modified Liposome Using Amphiphilic Doxorubicin for Tumor Targeting, J.-s. Choi*(1,2), B.-K. Kim(1), J.-W. Park(1), D.-B. Jeong(1), Y.-B. Seu(2), J.-H. Nam(3), K.-O. Doh(1); (1)College of Medicine, Yeungnam University, Daegu, Republic of Korea, (2)Kyungpook National University, Daegu, Republic of Korea, (3)DGMIF, Daegu, Republic of Korea

704. Remodelling of the Protein Corona on Long Circulating Single Molecule Soft Polymer Nanoparticles in vivo, L. Takeuchi*(1,2), S. Abbina(1,2,3), A. Parambath(1,2,3), K. Yu(1,2,3), J. Kizhakkedathu(1,2,3); (1)University of British Columbia, Vancouver, BC, Canada, (2)Centre for Blood Research, Vancouver, BC, Canada, (3)The University of British Columbia, Vancouver, BC, Canada

705. Ultrasound Mediated Release from Three Targeted Liposomes (Human Serum Albumin, Transferrin and RGD), G. Husseini*(1), N. Awad(1), V. Paul(1), M. Mahmoud(1), N. AlSawaftah(1), P. Kawak(1), M. Al Sayah(2); (1)American University of Sharjah, Sharjah, United Arab Emirates, (2)American University of Sharj, Sharjah, United Arab Emirates

706. Injectable Polyester Hydrogel-mediated Myeloid-derived Growth Factor Delivery for Improved Post Myocardial Infarction Heart Healing, Z. Li*, X. Xu; New Jersey Institute of Technology, Newark, NJ, USA

707. Improved Micellar Nanoparticle Stabilization, E. Green*, H. Acar; University of Oklahoma, Norman, OK, USA

708. The Efficiency of Cytosolic Delivery using pH-Responsive Endosomolytic Polymers does not Correlate with Activation of the NLRP3 Inflammasome, J. Baljon*(1), A. Dandy(2), L. Wang-Bishop(1), M. Wehbe(1), M. Jacobson(1), J. Wilson(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Tuskegee University, Tuskegee, AL, USA

709. Design of a Dendrimeric Nanomedicine Platform for the Treatment of a Neuro-Degenerative Disease, X-ALD, O. Gok*(1), C. Nemeth(2,3), K. Rangaramanujam(1,3), B. Turk(2,3), S. Kambhampati(1), F. Zhang(1), A. Sharma(1), S. Kannan(2,3,4), A. Fatemi(2,3); (1)Johns Hopkins University, Baltimore, MD, USA, (2)Johns Hopkins University School of Medicine, Baltimore, MD, USA, (3)Kennedy Krieger Institute, Baltimore, MD, USA, (4)Johns Hopkins University, School of Medicine, Baltimore, MD, USA

710. Magnetic nanogel delivery of transcription factor to adipose-derived stem cell for muscle tissue regeneration., N. Kinoshita*(1,2), Y. Sasaki(2), R. Kawasaki(2), E. Marukawa(1), H. Harada(1), K. Akiyoshi(2); (1)Tokyo Medical and Dental University, Bunkyo-ku, Japan, (2)Kyoto University, Kyoto, Japan

711. Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery, C. Maikawa*, A. Smith, E. Appel; Stanford University, Stanford, CA, USA

712. Implementing siRNA-Based Therapy of Chronic Myeloid Leukemia Ex Vivo by using Lipopolymeric Carriers, H. Uludag*(1), J. Valencia-Serna(1), C. Kucharski(1), M. Chen(2), R. K.C.(1), J. Brandwein(1), X. Jiang(2); (1)University of Alberta, Edmonton, AB, Canada, (2)University of British Columbia, Vancouver, BC, Canada

713. Development of magnetic micelles as anti-inflammation drug carrier for coronary atherosclerotic treatment, T.-R. Ger*, Y.-C. Huang, C.-M. Su, T.-Y. Chen, F. Dong, C.-K. Tsou; Chung Yuan Christian University, Taoyuan, Taiwan

714. RAGE targeting therapeutic exosome for drug delivery, G. Kim*, M. Lee, J. Ha; Hanyang University, Seoul, Republic of Korea

715. Dual Aptamer-functionalized In Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Co-delivery of Growth Factors, N. Zhao*; Penn State University, State College, PA, USA

716. Basic amino acids modified poly(amidoamine) generation 2 for delivery of plasmid DNA, Y.K. Lee*(2), L.T. Thuy(1), J.S. Choi(1), M. Lee(2); (1)Chungnam National University, Daejeon, Republic of Korea, (2)Hanyang University, Seoul, Republic of Korea

717. Using Machine Learning to Predict the Binding Dissociation of FDA Approved Drugs for Affinity-Based Drug Delivery Applications, E. Rivera Delgado*(1), A. Xin(2), H. von Recum(1); (1)Case Western Reserve University, Cleveland, OH, USA, (2)Hathaway Brown High School, Shaker Heights, OH, USA

Drug Delivery SIG

718. Microneedle-Assisted Topical Drug Delivery for Combination Therapy of Deep-Seated Melanoma, Y. Zhao*, H.P. Tham, T.G.S. Thng, S. Venkatraman, C. Xu; Nanyang Technological University, Singapore, Singapore

719. Blurring the Line Between Device and Drug by Targeting the Fibrin Blood Clot Niche, N. White*(1), X. Wang(1), R. Lamm(1), L. Chan(1), S. Pun(1), Y.S. Wong(2), S. Venkatraman(2); (1)University of Washington, Seattle, WA, USA, (2)Nanyang Technological University, Singapore, Singapore

720. The Effect of Halloysite Addition on Chitosan/HNTs Hydrogel Composites Material Properties, Y. Luo*, D. Mills; Louisiana Tech University, Ruston, LA, USA

721. Investigation of Diclofenac Sodium Release from Electrospun Composite Nanofibers of Poly (ε-caprolactone) and Chitosan, S. Saudi*, U. Adhikari, S. Aravamudhan, J. Sankar, N. Bhattarai; North Carolina A&T State University, Greensboro, NC, USA

722. 3D Printed Calcium Deficient Hydroxyapatite/Collagen/Platelet Rich Plasma Composite Scaffolds Functionalized with Sustained Release of Growth Factor for Bone Tissue Regeneration, J. Lee*, S.J. Chae, W. Kim, J. Lee, M. Yeo, G.H. Yang, H. Kim, Y. Choe, Y. Koo, G. Kim; Sungkyunkwan University (SKKU), SUWON-SI, Republic of Korea

723. Stem Cells-Derived Nano-Vesicles for Augmented Regenerative Repair of Vascular Elastic Matrix, S. Sankaranarayanan Thampi*, A. Ramamurthi; Cleveland Clinic, Cleveland, OH, USA

724. A Tumor-Specific Amplification of Oxidative Stress with Triggered Drug Release Nanoparticle for Cancer Therapy, L. Yang*, W. Zhuang, G. Li, Y. Wang; Sichuan University, Chengdu, China

725. Two-Photon AIE Probe Conjugated Theranostic Nanoparticles for Tumor Bioimaging and pH-Sensitive Drug Delivery, G. Li*, B. Ma, W. Zhuang, Y. Wang; Sichuan University, Chengdu, China

726. Redox and pH Dual-Responsive Polymeric Micelle with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy, W. Zhuang*, L. Yang, G. Li, Y. Bing; Sichuan University, Chengdu, China

727. Hyaluronic Acid-coated Gold Nanorods Enhancing Multivalent BMP2 peptide delivery for Chondrogenesis, K. Sansanaphongpricha*(1), P. Sonthithai(2), P. Kaewkong(2), S. Bamrungsap(1), W. Kosorn(2), N. Saengkrit(1); (1)NANOTEC, National Science and Technology Development Agency, Pathumthani, Thailand, (2)MTEC, National Science and Technology Development Agency, Pathumthani, Thailand

728. Antisense Oligonucleotides Delivery with Bioreducible Lipid-based Nanoparticles in vitro and in vivo, L. Yang*; Tufts University, Medford, MA, USA

729. Fine-tuning Lung Cancer Nanotherapy Using Closed Cardiopulmonary Circulation, D. Bölükbas*(1,2), C. Morrone(1), A. Doryab(1), S. Datz(3), D. Gössl(3), S. van Rijt(1), T. Stöger(1), T. Bein(3), S. Meiners(1), D. Wagner(1,2); (1)Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum München, Munich, Germany, (2)Lung Bioengineering and Regeneration, Department of Experimental Medical Sciences, Lund University, Lund, Sweden, (3)Department of Chemistry and Center for NanoScience (CeNS), University of Munich (LMU), Munich, Germany

730. Engineering Anti-Cancer Extracellular Vesicles via Lipid Hybridization and Layer-by-Layer Approaches, Y.-Y. Jhan*, G. Palou Zuniga, C. Bishop; Texas A&M University, College Station, TX, USA

731. Targeted Delivery of Kartogenin-Encapsulated Nanoparticles for Improved Uptake by Mesenchymal Stem Cells, B. Almeida*, Y. Wang, A. Shukla; Brown University, Providence, RI, USA

732. Cellulose-based Biopolymers for Controlled Drug Delivery: A Mechanistic Investigation, K. ODonnell*(1), N. Comolli(1), G. Oporto(2); (1)Villanova University, Villanova, PA, USA, (2)West Virginia University, Morgantown, WV, USA

733. Multilayered Drug Delivery Sheet that Allows Minimally Invasive Delivery to the Eye, H. Kaji*, Y. Sato, N. Nagai, T. Abe; Tohoku University, Sendai, Japan

734. Electrospun Pullulan Based Nanofibers for Medical Applications, A. Bossart*(1), S. Shady(2), D. Kalyon(2); (1)Stevens Institute of Technology, Hoboken, NJ, USA, (2)Stevens Institute of Technology, Hoboken, NJ, USA

735. Single Injection Delivery System for Sabin Inactivated Polio Vaccine, X. Lu*, K. McHugh, Z. Tochka, S. Rose, M. Taylor, T. Graf, E. Budina, R. Langer, A. Jaklenec; Massachusetts Institute of Technology, Cambridge, MA, USA

736. Targeted Drug Delivery System Using Core/Shell microgels Containing Magnetic Nanoparticles and conjugated with Specific Ligands, A. Jo*(1), J. Yoon(2), J.W. Chung(1); (1)Dong-A Univ., Busan, Republic of Korea, (2)Pusan national Univ., Busan, Republic of Korea

737. Photo-crosslinked GelMA Hydrogel as Drug Carriers to Locally Applicate Abaloparatide in Promoting Bone Defect Regeneration, Z. NING*, W. Lu, B. TAN; The university of Hong Kong, Hong Kong, Hong Kong

738. Guided Bone Regeneration (GBR) Membrane with Embedded Hydroxyapatite (HA) Pattern for Drug Loading, I.-G. Kang*(1), Y.-J. Seong(1), E.-H. Song(1), J.-Y. Kim(1), H.-E. Kim(1), C.-M. Han(2); (1)Seoul National University, Seoul, Republic of Korea, (2)Jeonju University, Jeonju, Republic of Korea

739. DNA Delivery to Cells by Ultrabithorax Protein-Based Materials, R. Booth*, K. Churion, A. Alvarez, S. Ramasamy, S. Bondos; Texas A&M Health Science Center, College Station, TX, USA

Non-Viral Delivery for Gene Therapy and Editing

740. Blood Compatibility and Biodistribution of Various Therapeutic Nucleic Acid (TNA) polyplexes, K.-T. Kim*(1), J. Halman(2), C. Macks(1), K. Afonin(2), J.S. Lee(1); (1)Clemson University, Clemson, SC, USA, (2)University of North Carolina, Charlotte, NC, USA

741. IL-21 Vector-tethering Nanofibers for Cancer Treatment Including Osteosarcoma, S.-Y. Yang*(1), X. Gong(1,2), J. Jiang(1), M. Ceylan(3), B. Dart(1), R. Asmatulu(2); (1)University of Kansas School of Medicine-Wichita, Wichita, KS, USA, (2)Wichita State University, Wichita, KS, USA, (3)Istanbul Commerce University, Istanbul, Turkey

742. Improving Poly(amidoamine) Dendrimer Gene Delivery via Physical Interaction with a Nuclear Localization Sequence Peptide, R. Cooper*(1), H. Yang(2,3,4); (1)Virginia Commonwealth University, College of Engineering, Richmond, VA, USA, (2)Virginia Commonwealth University; College of Engineering, Richmond, VA, USA, (3)Virginia Commonwealth University, School of Pharmacy, Richmond, VA, USA, (4)Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA

743. A Universal Intracellular Delivery and Cell Releasing System via the Photoporation of Polydopamine and the Thermal-Responsiveness of Poly(N-isopropylacrylamide), J. Wu*, Q. Yu, H. Chen; Soochow University, Suzhou, China

744. Novel, biodegradable, sugar-based gene carriers for cancer therapy, S. HONG*, M. AHN, R. AROTE; School of Dentistry, Seoul National University, Seoul, Republic of Korea

745. Cationic Lipopolymers: Simple, Versatile Carriers for Gene Delivery, H. Uludag*, R. K.C.(1), B. Thapa; (1)University of Alberta, Edmonton, AB, Canada

746. Asialoglycoprotein receptor targeted sugar-alcohol derivatives as gene carriers for cancer treatment, M. AHN*, S. HONG, R. Arote; School of dentistry,Seoul national university, Seoul, Republic of Korea

747. Nucleobase-Modified Polyamidoamine-Mediated miR-23b Delivery to Inhibit the Proliferation and Migration of Lung Cancer, H. Han*(1,2), Q. Li(1); (1)1Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Chanchun, China, (2)Tufts University, Medford, MA, USA

Synthetic Nanomaterials for Therapeutic Delivery

748. Biodegradable Nanoparticles for Enhanced Lymph Node Trafficking and Paracortex Penetration for Malaria Transmission Blocking Vaccines, G. Howard*(1), G. Verma(2), P. Khare(2), X. Ke(1), R. Dinglasan(2), H.-Q. Mao(1); (1)Johns Hopkins University, Baltimore, MD, USA, (2)University of Florida, Gainesville, FL, USA

749. Selective Protection of Proteins in Polymeric Biomaterials to Understand the Effect of Gastrointestinal Digestion on Oral Tolerance, H. Frizzell*, K. Woodrow; University of Washington, Seattle, WA, USA

750. Enhancing the Stability and Potency of the Adjuvant Poly(I:C) through Nanoparticle Encapsulation, E. Gale*(1), G. Agmon(2), A. Smith(2), E. Appel(2); (1)Stanford University School of Medicine, Stanford, CA, USA, (2)Stanford University, Stanford, CA, USA

751. The Establishment of a 4T1 Breast Cancer Model for TRAIL Immunotherapy Studies, J. Dombroski*, N. Jyotsana, Z. Zhang, M. King; Vanderbilt University, Nashville, TN, USA

752. Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy Through Concurrent HO-1 Inhibition and ROS Generation, H. Hyun*, E. Jung, S. Hong, D. Lee; Chonbuk National University, Jeonju, Republic of Korea

753. Intravenous Application of Bispecific Antibody for Cardiac Regenerative Therapy After Heart Ischemia/Reperfusion Injury, K. Huang*(1,2), Z. Li(2), T. Su(1,2), S. Hu(2), K. Cheng(1,2,3); (1)Comparative Medicine Institute, Raleigh, NC, USA, (2)North Carolina State University, Raleigh, NC, USA, (3)North Carolina State University and University of North Carolina, Raleigh, NC, USA

754. Internalization of Folate Receptor Targeting Nanoparticles into Ovarian Cancer Cell Lines, H. Acar*, K. Haddad, T. Le; University of Oklahoma, Norman, OK, USA

755. Effect of Heparin-Coated Magnetic Nanoparticles on Human Vascular Cells, N. Ghobrial*, B. Fellows, O. Mefford, D. Dean; Clemson University, Clemson, SC, USA

756. Combinational Effects of EPR, Folate Targeting and Shapes for Cancer Theranostic Nanocarriers, A. Rad*(1), W. Aresh(1), M.-P. Nieh(1), P.-S. Lai(2); (1)University of Connecticut, Storrs, CT, USA, (2)National Chung Hsing University, Taichung, Taiwan

757. Superparamagnetic Iron Oxide Nanoparticles Functionalized with Aggregation-Induced Emission Materials for Dual-Modal Fluorescence/MRI Imaging, S. Fu*(1), R. Jin(1), Z. Cai(1), H. Ai(1,2); (1)National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, (2)Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Biomaterial Technologies for Hemostasis and Wound Care

758. A Hydrogel-based Smart Bandage for Wound Monitoring and Treatment, M. Akbari*(1), B. Mirani(1), E. Pagan(1), A. Ghahary(2); (1)University of Victoria, Victoria, BC, Canada, (2)University of British Columbia, Vancouver, BC, Canada

759. Silk-ECM Composite 3D Printed Constructs for Burn Wound Healing, D. Chouhan*, B. Mandal; Indian Institute of Technology Guwahati, Guwahati, India

760. Enhanced Angiogenesis with Nitric Oxide Releasing Chitosan-PVA Hydrogel for Wound Healing, A. Hasan*(1,2), A.A. Zahid(1,2), R. Ahmed(1,2), R.u.R. Syed(1,2), R. Augustine(1,2); (1)Qatar University, Doha, Qatar, (2)Biomedical Research Center, Doha, Qatar

761. Coacervate-mediated Exogenous Growth Factor Delivery for Scarless Skin Regeneration, U. Park*(1), M.S. Lee(2), H.S. Yang(2), K. Kim(1); (1)Incheon National University, Incheon, Republic of Korea, (2)Dankook University, Cheonan, Republic of Korea

762. Human-based Nanocomposite Cryogels for Hemostatic and Wound Healing Applications, B. Mendes*(1,2,3), M. Gómez-Florit(1,2), L. Randall(4), P. Babo(1,2), R. Almeida(1,2), M. Detamore(4), R. Domingues(1,2,3), R. Reis(1,2,3), M. Gomes(1,2,3); (1)University of Minho, Guimarães, Portugal, (2)ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal, (3)The Discoveries Centre for Regenerative and Precision Medicine, University of Minho, Guimarães, Portugal, (4)The University of Oklahoma, Oklahoma, OK, USA

763. Melanogenesis Potential of EGF-Loaded Nano-Pillared Chitosan-Gelatin Films, S. Altuntas*(1,2,3), H. Dhaliwal(2), A. Eid Radwan(2,3), F. Buyukserin(1), M. Amiji(2); (1)TOBB University of Economics and Technology, Ankara, Turkey, (2)Northeastern University, Boston, MA, USA, (3)Harvard Medical School, Boston, MA, USA

764. Antimicrobial Hydrogel Foam Dressings for Improved Chronic Wound Healing, Z. Lan*(1), R. Kar(1), J. Yoon(1), T. Wilems(1), T. Buie(1), C. Whitfield(2), N. Cohen(2), E. Cosgriff-Hernandez(1); (1)University of Texas at Austin, Austin, TX, USA, (2)Texas A&M University, College Station, TX, USA

765. Hydrogen Bonding-Driven Self-coacervation of Mussel Foot Protein Mimics (MPMs) as Wet Biological Tissue Adhesives, P. ZHAO*, B. YANG, L. BIAN; The Chinese University of Hong Kong, Hong Kong, Hong Kong

766. Developing a Knitted, Antibacterial Wound Dressing Contact Layer for Infection Management, E. Gianino*, D. Pham, J. Gilmore; Clemson Universtiy, Clemson, SC, USA

767. Designing an Antimicrobial Knitted Wound Dressing for Vacuum Assisted Wound Closure, D. Zha*, P. Nakod, A. El-Shafei, M. King, T. He, A. Brown, S. Hudson; North Carolina State University, Raleigh, NC, USA

768. Fabrication of photocurable hemostatic agent with wound healing and rapid hemostatic effect, C.H. Park*(1,2), Y.J. Lee(1), S.H. Kim(1), M.T. Sultan(1), O.J. Lee(1), H.S. Park(1,2), G. Khang(3); (1)Hallym University, Chuncheon, Republic of Korea, (2)Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea, (3)Chonbuk National University, Jeonju, Republic of Korea

769. Reduced Graphene Oxide Impregnated GelMA hydrogel Promotes Angiogenic Activity in Chick Embryo Model, A. Hasan*(1,2), R.U.R. SYED(1,2), R. Augustine(1,2), A.A. Zahid(1,2), R. Ahmed(1,2); (1)Qatar University, Doha, Qatar, (2)Biomedical Research Center, Doha, Qatar

770. Gelatin-Graphene Oxide Aerogels Loaded with Natural Extracts for Hemostatic Applications, S. Guajardo*(1), T. Figueroa(1), J. Borges(1), M. Meléndrez(2), K. Fernández(1); (1)Department of Chemical Engineering, Faculty of Engineering, University of Concepcion, Concepcion, Chile, (2)Department of Materials Engineering, Faculty of Engineering, University of Concepcion, Concepcion, Chile

771. Human MSCs Delivery Via Extracellular Matrix-embedded Hydrogel Patch for Skin Wound Repair, K. Park*(1,2), J.H. Lee(1), S.S. Ha(1,2); (1)Korea Institute of Science and Technology, Seoul, Republic of Korea, (2)KIST School, University of Science and Technology (UST), Seoul, Republic of Korea

772. Integrating Plant Structures and Systems for Wound Healing: Decellularized Spinach Leaves as a Multifunctional Platform for Tissue Engineered Skin, E. English*(1), J. Gershlak(1), D. Dolivo(1), J. Goverman(2), G. Gaudette(1), T. Dominko(1), G. Pins(1); (1)Worcester Polytechnic Institute, Worcester, MA, USA, (2)Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

773. Artificial Skin Characterization Using Galvanic Skin Response Data, T.P. Ashok*, U. Pamidigantam, S. Sadhu, A. Shrirao; Rutgers University, New Brunswick, NJ, USA

Biomaterials Technologies for Precision Medicine

774. Tissue-on-a-Chip Platform for Mesenchymal Stem Cell Potency, R. Schneider*(1,2), E.K. Williams(1,3,4), J. García(1,5), R. Mannino(1,3,4), W. Lam(1,3,4), A. García(1,5); (1)Petit Institute, Georgia Institute of Technology, Atlanta, GA, USA, (2)School of Chemical and Bimolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA, (3)Coulter Department, Georgia Institute of Technology & Emory University, Atlanta, GA, USA, (4)Emory University School of Medicine, Atlanta, GA, USA, (5)Woodruff School, Georgia Institute of Technology, Atlanta, GA, USA

775. Gelatin-based Thiol/Disulfide Degradable Hydrogels to Encapsulate Cells, J. Serrano*(1), A. Gilchrist(1), B. Harley(1), A. García(2); (1)University of Illinois at Urbana-Champaign, Urbana, IL, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA

776. Identification of IL-27 as Potent Regulator of Osteolysis Triggered by of Orthopaedic Implants Debris, D. Takahashi*, M.A. Terkawi, G. Matsumae, Y. Tian, H. Alhasan, N. Iwasaki; Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

777. Analysis of Ultrasound Sensitive Polyurethane-Glass Composites, J. Contreras*(1), A. Stimpson(2), I. Ahmed(2), D. Irvine(2), A. Whittington(1,3); (1)Virginia Tech, Blacksburg, VA, USA, (2)University of Nottingham, Nottingham, United Kingdom, (3)Virginia Tech, Blacksburg, VA, USA

Engineered Biomaterials for Neural Applications

778. Porous Hydrogels for Neural Implants: Effect of Pore Size on Glial Encapsulation, I. Dryg*, L. Crawford, S. Perlmutter, J. Bryers, B. Ratner; University of Washington, Seattle, WA, USA

779. Comparison of Hydrogel Encasement Strategies for Implantable Micro-Tissue Engineered Nerve Grafts, J. Burrell*(1,2), S. Das(1,2), K. Katiyar(1,2), F. Laimo(1,2), Z. Ali(1), D.K. Cullen(1,2); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)CMC VA Medical Center, Philadelphia, PA, USA

780. Engineered Dopaminergic Axonal Tracts within a Tubular Hydrogel Encasement for Living Deep Brain Stimulation in Parkinson’s Disease, W. Gordián Vélez*(1,2,3), L. Struzyna(1,2,3), K. Browne(2,3), J. Burrell(1,2,3), J. Wolf(2,3), J. Duda(3), H.I. Chen(2,3), D.K. Cullen(1,2,3); (1)School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA, (2)Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, (3)Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA

781. Self-Assembled Aligned Glial Cells as "Living Scaffold" for Nervous System Repair, J. Burrell*(1,2), J. O'Donnell(1,2), K. Panzer(1,2), K. Helm(1,2), K. Katiyar(1,2), K. Browne(1,2), W. Gordián-Vélez(1,2), D.K. Cullen(1,2); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)CMC VA Medical Center, Philadelphia, PA, USA

782. A Surgical Approach for Spinal Cord Regeneration Based on a 3d Printable Device Able to Provide a Defined Protective Environment, A. Merolli*, B. Varghese, Y. Mao, J. Kohn; Rutgers - The State University of New Jersey, Piscataway, NJ, USA

783. Effects of Microarchitecture on Schwann Cell Migration and Proliferation in Magnetically Templated Hydrogels in vitro, I. Singh*, M. Kasper, C. Lacko, C. Schmidt, C. Rinaldi; University of Florida, Gainesville, FL, USA

784. Development of an in vitro Traumatic Brain Injury Model Using 3D Cultured Neural Stem Cells and 3D Printed Device, W. Shi*(1), M. Kuss(1), P. Dong(2), L. Gu(2), H.J. Kim(1), B. Duan(1,2); (1)University of Nebraska Medical Center, Omaha, NE, USA, (2)University of Nebraska-Lincoln, Lincoln, NE, USA

785. A Sequential Double Non-Flourescent Immunostaining for the Easy Identification of the Motor Component in the in vivo Study of Biomaterials for Peripheral Nerve Regeneration, A. Merolli*, P. Louro, J. Kohn; Rutgers - The State University of New Jersey, Piscataway, NJ, USA

786. The Fabrication of Melanin Containing Electrospun Scaffolds for Neural Cell Applications, N. Iwakoshi*, V. Krivoruk, J. McKenzie; Walla Walla University, College Place, WA, USA

787. PLA-HPG Nanoparticles as a Therapeutic Carrier for Spinal Cord in Adult Mice, M. Khang*(1), A. Lynn(1), H.W. Suh(1), Y.E. Seo(1), R. Bindra(2), M. Saltzman(1); (1)Yale University, New Haven, CT, USA, (2)Yale School of Medicine, New Haven, CT, USA

788. A novel bioactive system based on surface-functionalized plasmonic nanosystems for tunable biological surfaces, K. Alghazali*(1), S. Newby, Z. Nima(1), R. Hamzah(1), F. Watanabe(1), T. Masi(2), S. Stephenson(2), D. Anderson(2), M. Dhar(2), A. Biris(1); (1)University of Arkansas at Little Rock, little rock, AR, USA, (2)University of Tennessee, Knoxville, TN, USA

789. Effect of Microbial Metabolites on in vitro Enteric Nervous System Tissue Model, E. Manousiouthakis*, N. Alden, M. Dente, O. Hofheinz, K. Lee, D. Kaplan; Tufts University, Medford, MA, USA

790. Self-assembled human induced pluripotent stem cell-derived brain organoids on PEG hydrogels for modeling melanoma metastasis, E. Aisenbrey*, E. Torr, V. Harms, W. Murphy; University of Wisconsin, Madison, WI, USA

Engineered Microenvironments in Health and Disease

791. Developing a Spatially-Defined Biomaterial Model of the Glioblastoma Perivascular Niche, C. Hunter*, M. Ngo, B. Harley; University of Illinois at Urbana-Champaign, Urbana, IL, USA

792. Development of the CellWell™ - A Novel Micropatterned Biphasic Nanocomposite Platform for Chondrocyte Cell Culture, R. Saraswat*(1), W. Schutz(1,2), Z. Zhu(1), P. Ahrenkiel(1), S. Wood(1); (1)South Dakota School of Mines & Technology, Rapid City, SD, USA, (2)University of Wyoming, Laramie, WY, USA

793. Versatile Core-Shell Microgels for Cell Encapsulation in Three-Dimensional Cell Culture, H. Chen*, L.P. Tan; Nanyang Technological University, Singapore, Singapore

794. An in vitro Disease Model for Aggressive Hodgkin's Lymphoma, L. Bahlmann*(1), M. Shoichet(1), A. Baker(1), R. Laister(2); (1)University of Toronto, Toronto, ON, Canada, (2)Princess Margaret Cancer Centre, Toronto, ON, Canada

795. Controlling Fibrosis Stage of iPS-derived Myocardial Models by Micro-Scaffold Technique, M. Matsusaki*(1), K. Nishi(1), J.-K. Lee(2), S. Miyagawa(2), Y. Sawa(2); (1)Graduate School of Engineering, Osaka University, Osaka, Japan, (2)Graduate School of Medicine, Osaka University, Osaka, Japan

796. Chondrogenesis of Mesenchymal Stromal Cells Modulated by Cell-Cell and Cell-Matrix Interactions, Y. Xiao*(1), Y. Wang(2), D. Huang(1), X. Zhang(1,2); (1)Sichuan University, Chengdu, China, (2)Guangxi Medical University, Nanning, China

797. Studying the Effects of Pro-inflammatory Cytokines on Breast Cancer Metastasis in a Three-Dimensional Model, M. Williams*, J. Alsaleh, C. Gomillion; University of Georgia, Athens, GA, USA

798. Printable Cell Culture Platform, D. Soto Veliz*, M. Toivakka; Abo Akademi University, Turku, Finland

799. Engineering the in vitro Microenvironment of Human Schwann Cells by Providing Electrical Firing Artificial Axons, A. Merolli*, Y. Mao, G. Voronin, J.AM. Steele, J. Kohn; Rutgers - The State University of New Jersey, Piscataway, NJ, USA

800. Engineering A Biomimetic Environment To Pre-Condition Stem Cells For Efficacious Cardiovascular Repair, A. Raghavachar Chakravarti*, S. Pacelli, S. Bagchi, P. Alam, S. Modaresi, A. Czirock, R. P.H. Ahmed, A. Paul; University of Kansas, Lawrence, KS, USA

801. Fabrication of 3D Lymph Node Mimetic and Its Potential for Cancer Diagnosis, A. Hakamivala*, J.-T. Hsieh, L. Tang; The University of Texas at Arlington, Arlington, TX, USA

802. Hyperosmolar Potassium Depolarization Suppresses Pro-inflammatory Macrophage Activation, H. Chen*, J. Enrdt-Marino, M. Hahn; Rensselaer Polytechnic Institute, Troy, NY, USA

803. Fibrotic Cytokine TGF-B1 Increases Pericyte Migration in a 3-D Microvascular Model, T. Chung*, A. Pellowe, A. Gonzalez; Yale University, New Haven, CT, USA

804. Targeting Adult Stem Cell-Derived Smooth Muscle Cells to the Aortal Wall for Augmented ECM Repair, S. Dahal*(1,2), A. Ramamurthi(1,2,3); (1)The Cleveland Clinic, Cleveland, OH, USA, (2)Cleveland State University, Cleveland, OH, USA, (3)Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

805. Engineered Nanoclay Based Bone-Mimetic 3D in vitro Test-Bed for Bone Metastasis of Breast Cancer, S. Kar*, K. Katti, D. Katti; North Dakota State University, Fargo, ND, USA

806. Engineering Hydrogel Based Cancer Microenvironments for in Vitro Breast Cancer Cell Culture and Therapeutics Screening, W. Shi*(1), M. Kuss(1), B. Mohapatra(1), S. Mirza(1), H. Band(1), V. Band(1), B. Duan(1,2); (1)University of Nebraska Medical Center, Omaha, NE, USA, (2)University of Nebraska-Lincoln, Lincoln, NE, USA

807. Porous Chitosan-Chondroitin Sulfate Scaffolds To Mimic The Prostate Cancer Microenvironment, K. Xu*(1), S. Florczyk(1,2), Z. Wang(1), J. Copland(3), R. Chakrabarti(2), K. Ganapathy(2); (1)University of Central Florida, Orlando, FL, USA, (2)University ofCentral Florida, Orlando, FL, USA, (3)Mayo Clinic, Jacksonville, FL, USA

808. A Microfluidic Platform to Generate 3D in vitro Blood Vessels for the Study of Biofilm Dispersion, J. Li*; University of Wisconsin-Madison, Madison, WI, USA

809. Investigation into Soft Tissue Micro-Tearing and Repair Mechanisms as it Relates to Sports Injuries, A. Seilkop*, M. Maggio, M. Judge, O. Newkirk, D. Dean; Clemson University, Clemson, SC, USA

810. Effect of Low Intensity Ultrasound on the Differentiation of Liver Cancer Stem-like Cells, I-Chi Lee*(1), S. Fadera(1), H.-L. Liu(2); (1)Chang-Gung University, Taoyuan, Taiwan, (2)Chang Gung University, Taoyuan, Taiwan

811. Inhibition of Extratumoral Chondroitin Sulfate Glycosaminoglycans Stems Glioma Cell Invasion, M. Logun*(1), G. Simchick(1), W. Zhao(1), L. Mao(1), Q. Zhao(1), S. Mukherjee(2), D. Brat(2), L. Karumbaiah(1); (1)University of Georgia, Athens, GA, USA, (2)Northwestern University Feinberg School of Medicine, Chicago, IL, USA

812. Tumor Invasion through Hyaluronic Acid Matrices is Mediated by CD44-Dependent Microtentacles, K. Wolf*(1,2), S. Kenny(1), S. Lee(1,2), P. Shukla(1), C. Choy(1), K. Xu(1,3), S. Kumar(1,2); (1)University of California, Berkeley, Berkeley, CA, USA, (2)University of California, Berkeley - University of California, San Fransisco, Berkeley, CA, USA, (3)Lawrence Berkeley National Laboratory, Berkeley, CA, USA

813. Hypoxia and Matrix Viscoelasticity Sequentially Regulate Endothelial Progenitor Cluster-Based Vasculogenesis, M. Blatchley*(1,2), F. Hall(1,2), S. Wang(2), H. Pruitt(2), S. Gerecht(1,2); (1)Johns Hopkins University School of Medicine, Baltimore, MD, USA, (2)Johns Hopkins University, Baltimore, MD, USA

814. A Decoupled Multi-Stimulus Bioreactor for Studying Complex Chemo-Mechanical Microenvironments In Vitro, B. James*, N. Montoya, W. Ruddick, J. Allen; University of Florida, Gainesville, FL, USA

Engineering Cells and Their Microenvironments SIG

815. A Chem-Bio Approach for Stable Display of Synthetic Glycopolymers on Cell Surfaces, Q. Liu*, G. Chen, H. Chen; Soochow University, Suzhou, China

816. Patient Derived Glioblastoma Cells Activate Microglia in a Three-Dimensional Gelatin Hydrogel, J.W. Chen*, J. Lumibao, H.R. Gaskins, B. Harley; University of Illinois Urbana-Champaign, Urbana, IL, USA

817. Hypoxia-Inducing Cryogels for Preclinical Anticancer Drug Screening, T. Colombani*(1), J. Sinoimeri(1), S. Bencherif(1,2,3); (1)Northeastern University, Boston, MA, USA, (2)Harvard University, Boston, MA, USA, (3)Sorbonne University, Compiegne, France

818. Morphological Adaptations in Breast Cancer Cells as a Function of Prolonged Passaging on Compliant Substrates, S. Syed*(1), A. Blanco(1), J. Schober(2), S. Zustiak(1); (1)Saint Louis University, Saint Louis, MO, USA, (2)Southern Illinois University Edwardsville, Edwardsville, IL, USA

819. Bioengineered 3D Interpenetrating Collagen-Alginate Network to Examine the Effects of Matrix-Mechanics on Cancer-associated Fibroblasts (CAFs) Behaviour, H. Cao*, M. Lee, H. Yang, S. Sze, N. Tan, C. Tay; Nanyang Technological University, Singapore, Singapore, Singapore

820. Using Hydrogel Composite Models to Study Extracellular Matrix Induced Morphology and Migration Changes in Brian Cancer Cells, Y. Cui*, S. Cole, J. Winter; The Ohio State University, Columbus, OH, USA

821. Human Her2- Positive Breast Cancer Cell Redirection In Vitro, A. Frank-Kamenetskii*, J. Mook, B. Booth; Clemson University, Clemson, SC, USA

822. Surface Modification of PCL Scaffold using Collagen Fibrillation for Muscle Tissue Regeneration, S.J. Chae*, J. Lee, M. Yeo, J. Lee, G. Kim, W. Kim; Sungkyunkwan University, SUWON-SI, Republic of Korea

823. Phospholipid Polymer Multilayered Hydrogels Containing Cells for Cancer Drug Screening, K. Ishihara*, B. Gao, T. Konno; The University of Tokyo, Tokyo, Japan

824. Surface Engineering of Macrophages with Nucleic Acid Aptamers for Capture of Tumor Cells, Y. Iwasaki*, S. Sugimoto; Kansai University, Osaka, Japan

825. Alginate Based Hydrogel Platform for Cell Encapsulation, S. Khanal*, S. Tatum, J. Sankar, N. Bhattarai; North Carolina A&T State University, Greensboro, NC, USA

826. The Effect of Migration on MSC Differentiation Through Activating Wnt Signal Pathway, R. Yao*, J. He, F. Wu; Engineering Research Center in Biomaterials, Chengdu, China

827. Understanding Structure-Property Relationships in Biological Tissues and Bioinspired Materials Using Non-Destructive Characterization Techniques, P. Labroo*, J. Irvin, M. Petney, J. Johnson, N. Sopko; PolarityTE, Inc, Salt Lake City, UT, USA

828. Single Cell Analysis Reveals the Instructive Role of 2D and 3D Engineered Microenvironments on Driving Stem Cell Behavior, A. Muniz*, M. Brooks, D. Neale, T. Topal, A. Sze, M. Wicha, J. Lahann; The University of Michigan, Ann Arbor, MI, USA

829. Development of Vascularized 3D-Tissues with High ECM Density by Collagen Microfibers, Y. Naka, II*(1), K. Nishi, II(1), M. Matsusaki(1,2); (1)Graduate School of Engineering, Osaka University, Suita, Japan, (2)Japan Science and Technology Agency, Chiyoda-ku, Japan

830. Extracellular Matrix Functionalized Multi-Cell Aggregate for Wound Repair, P. Labroo*, J. Irvin, N. Baetz, I. Robinson, J. Meiss, M. Sieverts, D. Miller, N. Sopko; PolarityTE, Inc, Salt Lake City, UT, USA

831. Effect of Local Injection of Osteoblastic Cells Differentiated from Bone Marrow or Adipose Tissue-Mesenchymal Stromal Cells on Bone Repair, G. Pereira Freitas*(1), H. Bacha Lopes(1), A.T. Portilho de Souza(1), P.G. Faciola Pessôa de Oliveira(1), A.L. Gonçalves de Almeida(1), P.G. Coelho(2), M.M. Beloti(1), A.L. Rosa(1); (1)School of Dentistry of Ribeirão Preto - University of Sao Paulo, Ribeirao Preto, Brazil, (2)New York University College of Dentistry, New York, NY, USA

832. Construction of ceramic-polymeric materials to generate neo bone tissue, G. Flores*(1), R. Olayo(2), J. Morales(2), A. Raya(3), D. Esquiliano(3), P. Ontiveros(4); (1)Universidad La Salle, Mexico City, Mexico, (2)Autonomous Metropolitan University, Mexico City, Mexico, (3)Child Hospital of Mexico Federico Gomez, Mexico City, Mexico, (4)Department of Pathology, Morelos, Mexico

Functional Biomaterials to Control and Direct Cellular Function

833. Novel TiO2 Hemisphere Surface Matrices Determine the Osteogenic Differentiation and Mineralization of Pre-Osteoblastic Cells, Z. Yizhou*(1), S. Wu(2), K. Yeung(1); (1)The University of Hong Kong, Hong Kong, Hong Kong, (2)Hubei University, Wuhan, China

834. Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells, A. Killaars*(1,2), J. Grim(1,2), C. Walker(1,2), E. Hushka(1,2), T. Brown(1,2), K. Anseth(1,2); (1)University of Colorado, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA

835. Human Dermal Fibroblast Spheroids Combined with Platelets Rich Plasma Promote Skin Remodeling in a Skin Wrinkle Model of Aged Nude Mice, S. Hu*(1,2), Z. Li(1,2), K. Huang(2), T. Su(1,2), K. Cheng(1,2); (1)North Carolina State University and the University of North Carolina at Chapel-Hill, Chapel Hill, NC, USA, (2)North Carolina State University, Raleigh, NC, USA

836. Extracellular Matrix Derived from Chondrocytes Promotes Rapid Expansion of Human Primary Chondrocytes in vitro with Reduced Dedifferentiation, Y. Mao*(1), T. Block(2), A. Singh-Varma(1), A. Sheldrake(2), R. Leeth(2), S. Griffey(2), J. Kohn(1); (1)New Jersey Center for Biomaterials, Piscataway, NJ, USA, (2)StemBioSys, San Antonio, TX, USA

837. Temperature-dependent Binding of Growth Factors and Cells to a Heparin-Immobilized Thermoresponsive Surface, J. Kobayashi*, Y. Akiyama, M. Yamato, T. Okano; Tokyo Women's Medical University, Tokyo, Japan

838. Photopatterned Protein Immobilization in Natural-based Hydrogels, I. Batalov*, C. DeForest, K. Stevens; University of Washington, Seattle, WA, USA

839. In vitro and in vivo Evaluation of Amorphous Silica Osteochondral Matrix, H. Kim*, S. Nukavarapu; University of Connecticut, Storrs, CT, USA

840. Varying HRP Crosslinking Strategy Enables Tunable Fibrin Microthread Mechanical Properties, M. Carnes*(1), R. Mooney(2), C. Gonyea(1), J. Coburn(1), G. Pins(1); (1)Worcester Polytechnic Institute, Worcester, MA, USA, (2)Bucknell University, Lewisburg, PA, USA

841. Vascularization is Mediated by Scaffold Pore Size to Direct Bone Marrow Stromal Cell Fate, B. Swanson*, P. Ma; University of Michigan, Ann Arbor, MI, USA

842. A Cell Glue: Inducing Cell Adhesion Using Surface Modification with Cell-Penetrating Peptide-PEG-Lipid for 3D Cell Structures, Y. Teramura*(1,2), S. Asif(2), E. Gustafson(3), K. Ekdahl(2,4), B. Nilsson(2); (1)The University of Tokyo, Tokyo, Japan, (2)Uppsala University, Uppsala, Sweden, (3)Uppsala University Hospital, Uppsala, Sweden, (4)Linnæus University, Växjö, Sweden

843. Modified Biomimetic Nanofibrous Scaffold Modulates Phenamil-Induced Stem Cell Differentation, Y. Liu*(1), H. Sun(2); (1)University of South Dakota, Sioux Falls, SD, USA, (2)University of Iowa, Iowa City, IA, USA

844. Enzymatically Triggered Shape Memory Polymers Direct Cell Alignment, S. Buffington*(1), M. Ali(1,2), P. Mather(2), J. Henderson(1); (1)Syracuse University, Syracuse, NY, USA, (2)Bucknell University, Lewisburg, PA, USA

845. Reversible Dynamic Mechanics of Hydrogels for Regulation of Cell Behaviors, O. Jeon*(1,2), T.-H. Kim(1), E. Alsberg(1,2); (1)Case Western Reserve University, Cleveland, OH, USA, (2)University of Illinois at Chicago, Chicago, IL, USA

846. Dynamic PEG-Peptide Hydrogels via Visible Light-Induced Tyrosine Dimerization, C.-C. Lin*(1,2), H.-Y. Liu(1); (1)Purdue University, West Lafayette, IN, USA, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

847. Iron Oxide Nanoparticles Suppress RANKL-induced Osteoclastogenesis through Regulating NF-κB and MAPK Signaling Pathways, L. Liu*(1), J. Duan(1), L. Yang(1), R. Jin(1), H. Ai(1,2); (1)National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, (2)West China Hospital, Sichuan University, Chengdu, China

848. Effect of Poly(Sophorolipid) Functionalization on Human Mesenchymal Stem Cell Osteogenesis and Immunomodulation, A. Arabiyat*, P. Diaz Rodriguez, J. Erndt-Marino, F. Totsingan, S. Mekala, R. Gross, M. Hahn; Rensselaer Polytechnic Institute, Troy, NY, USA

849. Priming via Three-Dimensional Culture in Hydrogels Accelerates Retroviral Gene Transduction of Human Mesenchymal Stem Cells, B. Choi*(1), Y. Lee(1), D.K. Han(1), S.-H. Lee(1,2); (1)CHA University, Seongnam-si, Republic of Korea, (2)Dongguk University, Goyang-si, Republic of Korea

850. Bivalent Metal Ions Modulate Human Mesenchymal Stem Cell Osteogenic Differentiation, A. Brokesh*, A. Kersey, L. Cross, A. Gaharwar; Texas A&M University, College Station, TX, USA

851. Particle Based Hydrogel Heterogeneity for Controlled Cellular Infiltration, L. Pruett*, D. Griffin; University of Virginia, Charlottesville, VA, USA

852. Visible-Light Triggered Shape Memory Polymers to Direct Cell Morphology, S. Buffington*(1), J. Henderson(1), J. Waimin(1), J. Apyapong(1), P. Mather(2); (1)Syracuse University, Syracuse, NY, USA, (2)Bucknell University, Lewisburg, PA, USA

853. Glycosaminoglycans and Scaffold Morphology Influence Trabecular Meshwork Cell Behavior, M. Osmond*(1), M. Pantcheva(2), M. Krebs(1); (1)Colorado School of Mines, Golden, CO, USA, (2)University of Colorado Denver School of Medicine, Aurora, CO, USA

854. Valence State of Cerium Oxide Nanoparticles Manipulate the Fate of Macrophages and Mesenchymal Stem Cells and Subsequent Bone Formation, K. Yeung*(1,2), J. Li(1,2,3), J. Wei(4), W. Li(3), W. Qiao(5), J. Shen(1,2), W. Jin(3), X. Jiang(4), P. Chu(3), B. Li(6); (1)The University of Hong Kong (1), Hong Kong, Hong Kong, (2)The University of Hong Kong-Shenzhen Hospital, Shenzhen, China, (3)City University of Hong Kong, Hong Kong, Hong Kong, (4)Ninth People’s Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China, (5)The University of Hong Kong (2), Hong Kong, Hong Kong, (6)The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

855. Functionalized Polyurethane Foams as Tissue Scaffolds with Enhanced Cellular Response, M.C. Tanzi*(1), D. Gantz(2), S. Bertoldi(2), N. Contessi Negrini(2), H.J. Haugen(3), (1)INSTM Local Unit, (2)CMIC Dept. "G. Natta", Politecnico di Milano, Italy (3) Dept. of Biomaterials, Inst. of Clinical Dentistry, University of Oslo, Norway

856. Reversible Thermosensitivity of Completely Natural Mammalian Collagen Gels by Microfiberization, Y. Yukawa*(1), H. Nakatsuji(2), S. Irie(2), M. Matsusaki(1,2,3); (1)Graduate School of Engineering, Osaka University, Suita, Japan, (2)Joint Research Laboratory (TOPPAN) for Advanced Cell Regulatory Chemistry, Suita, Japan, (3)Japan Science and Technology Agency, Chiyodaku, Japan

857. Modulation of Stem Cell Morphology and Differentiation Using a Mussel-Inspired Gelatin-Based Hydrogels, S. Pacelli*, S. Modaresi, A. R. Chakravarti, F. Elmi Vergel, C. Kurlbaum, M. Fang, F. Castanho, S. Basu, A. Paul; The University of Kansas, Lawrence, KS, USA

858. A Synthetic Replica Having Surface Morphology of Decellularized Tissue Regulated Orientation and Shape of Cells, T. Kimura*(1), M. Kobayashi(1), Y. Hashimoto(1), T. Fujisato(2), N. Nakamura(3), A. Kishida(1); (1)Tokyo Medical and Dental Univeristy, Tokyo, Japan, (2)Osaka Institute of Technology, Osaka, Japan, (3)Shibaura Institute of Technology, Saitama, Japan

859. Multi-layered Films of Self-Assembled Capillary Alginate Hydrogel (CapgelTM) Induces Preferential Orientation of Human Foreskin Fibroblasts, B. Willenberg*(1,2), M. Kwan(1), C. Wheeless(1), M. Mathews(1), K. Crawford(1); (1)University of Central Florida, Orlando, FL, USA, (2)Saisijin Biotech, LLC, St. Cloud, FL, USA

860. Stimuli-responsive Sol-Gel Transition Polymers with Dynamic Crosslinks for Cell Culture, T. Miyata*, Y. Natsume, A. Matsuda, K. Okuma, C. Norioka, K. Okita, A. Kawamura; Kansai University, Osaka, Japan

861. Synthetic Hydrogel Culture Sequesters Extracellular Matrix Proteins and Promotes Fibroblast Proliferation, I. Kopyeva*(1), C. Tomaszewski(2), A. Shikanov(2,3); (1)University of Michigan, Ann Arbor, MI, USA, (2)The University of Michigan, Ann Arbor, MI, USA, (3)U of Michigan, Ann Arbor, MI, USA

862. Agarose for Mechanical Control of Self-Assembling Peptide Systems, K. Firipis*(1,2), M. Boyd-Moss(1,2), A. Quigley(2,3), D. Nisbet(4), R. Williams(1,2); (1)RMIT University, Melbourne, Australia, (2)BioFab3D, Melbourne, Australia, (3)University of Wollongong, Wollongong, Australia, (4)Australian National University, Canberra, Australia

863. Effect of Freeze-Thaw Cycling on the Mechanics of Poly(Vinyl Alcohol)-Gelatin Cryo-Theta-Gels, P. Charron*, R. Oldinski; University of Vermont, Burlington, VT, USA

864. Dynamic Modulation of Gelatin Methacrylate Hydrogel Stiffness for Functional Maturation of Human Stem Cell-Derived Cardiac Tissues, G. Tansik*(1,2,3), A. Alassaf(1), V. Mayo(1), D. Velluto(4), A. Agarwal(1,2,3,4); (1)University of Miami, Coral Gables, FL, USA, (2)University of Miami Miller School of Medicine, Miami, FL, USA, (3)DJTMF Biomedical Nanotechnology Institute, University of Miami Miller School of Medicine, Miami, FL, USA, (4)Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA

865. Influence of Nuclear Morphology on Differentiation of Mesenchymal Stem Cells, X. Wang*, V. Agrawal, C. Duan, B. Jiang, V. Backman, G. Ameer; Northwestern University, Evanston, IL, USA

866. Biorthogonal Shear Thinning Hydrogels to Generate Macroscale Cellular Organization and Spatially Patterned Microenvironmental Physiochemical Cues, A. Dang*, J. Gleghorn; University of Delaware, Newark, DE, USA

867. Multicomponent Assembly of Biomaterial Scaffolds as Instructive Cellular Environments, R. Williams, III*(1), D. Nisbet, V(2); (1)RMIT University, Melbourne, Australia, (2)Australian National University, Canberra, Australia

868. Porosity effects on the biocompatibility of PEEK and Titanium-6Aluminum-4Vanadium, K. Nobles*, P. Pal, A. Janorkar, R. Williamson; University of Mississippi Medical Center, Jackson, MS, USA

869. Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation, Z. Chen*(1), S. He(2), W. Lee(1), J. Zilberberg(2); (1)Stevens Institute of Technology, Hoboken, NJ, USA, (2)Hackensack University Medical Center, Nutley, NJ, USA

870. Application of Chemically Defined Polymer to Existing Cell Culture Materials for hMSC Expansion, J. Krutty*, K. Koesser, S. Schwartz, A. Dias, W. Murphy, P. Gopalan; University of Wisconsin-Madison, Madison, WI, USA

Immune Engineering SIG

871. Nanoparticle-mediated Knockdown of TGFBR2 Improves Natural Killer Cell Cytotoxicity, I. Adjei*(1), J. Jordan(1), N. Tu(2), T.L. Trinh(2), S. Wei(2), B. Sharma(1); (1)University of Florida, Gainesville, FL, USA, (2)Moffitt Cancer Center, Tampa, FL, USA

872. Developing a 3D -Spatially Patterned Lymph Node Lobule on Chip, J. Ortiz-Cárdenas*, R. Pompano, A. Montalbine; University of Virginia, Charlottesville, VA, USA

Immunomodulatory Biomaterials

873. Bioresponsive Microspheres for On-demand Delivery of Anti-inflammatory Cytokines for Inflammatory Arthritis, R. T. Annamalai*(1), E. Park(1,2), M. Hart(2), B. Rolauffs(2), J. Stegemann(1); (1)University of MIchigan, Ann Arbor, MI, USA, (2)University of Freiburg, Freiburg, Germany

874. Targeting Infiltrating Immune Cells to Improve Articular Cartilage Regeneration, F. Taraballi*(1,2), G. Bauza(1,2,3), L. Francis(3), A. Zhang(1), M. Hopson(2), S. Shaikh(2), F. Cabrera(1), X. Wang(1), A. Shi(1), D. Hamilton(1); (1)Houston Methodist Research Insistute, Houston, TX, USA, (2)Houston Methodist Hospital, houston, TX, USA, (3)Swansea University, Swansea, United Kingdom

875. Altering Metabolism Repolarizes Proinflammatory Human Macrophages, B. Singh*, K. Wofford, K. Spiller; Drexel University, Philadelphia, PA, USA

876. Engineering PEG-4MAL Hydrogels for Tolerogenic Dendritic Cells, N. Beskid*(1), A. García(1), J. Babensee(2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Georgia Institute of Technology and Emory University, Atlanta, GA, USA

877. Identification of CD137-Exosomes and Exploration of Their Immunomodulatory Capacity, Y. Zhou*, H. Schwarz; National University of Singapore, Singapore, Singapore

878. Modulation of Macrophage Phenotype via Phagocytosis of Drug-Loaded Microparticles, K. Wofford*(1,2,3), D Cullen(2,3), K. Spiller(1); (1)Drexel University, Philadelphia, PA, USA, (2)Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA, (3)University of Pennsylvania, Philadelphia, PA, USA

879. Design of Rapidly Eroding Polyanhydride Nanoparticles for Drug and Vaccine Delivery, S. Kelly*, A. Mullis, S. Jacobson, A. Mitra, B. Narasimhan; Iowa State University, Ames, IA, USA

880. Crosslinking of Ovalbumin Nanoparticles Affects Cellular and Humoral Immune Responses, S. Christau*(1), N. Habibi(1), L. Ochyl(1), M. Kuehnhammer(2), R. von Klitzing(2), J. Moon(1), J. Lahann(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)Technical University Darmstadt, Darmstadt, Germany

881. Environment-Responsive Two-Fluorophore Reporter System: A Potential Tool to Monitor Particulate Vomocytosis, N. Pacifici*(1), A. Bolandparvaz(1), S. Shams(1), R. Stilhano(1,2), E. Silva(1), J. Lewis(1); (1)University of California, Davis, Davis, CA, USA, (2)Federal University of Sao Paulo, São Paulo, Brazil

882. An Improved Isolation Method of Tolerogenic Polysaccharides via High Performance Chromatography, R. Harriman*, K. Alvarez, L. Mckibbin, B. Noorafkan, J. Lewis; University of California, Davis, Davis, CA, USA

883. Biphasic Response of T cell Activation to Substrate Rigidity, D. Yuan*, L. Kam; Columbia University, New York, NY, USA

884. Supplementing Cell Membrane-coated PLGA Nanoparticles with Exogenous Phosphatidylserine Reduces Inflammatory Cytokine Production in Macrophages, C. Kraynak*, L. Suggs; The University of Texas at Austin, Austin, TX, USA

Next-Generation Biomaterials for Treatment of Type 1 Diabetes

885. Functionalization of Alginate with Rgd Peptide to Enhance Viability and Function of Encapsulated Islets, J. Medina*(1), A. Garcia(1), P. de Vos(2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)University of Groningen, Groningen, Netherlands

886. Conformal Coating Process Refinement and Materials Optimization Improves the Insulin Secretion of Encapsulated Islets, A. Stock*(1,2), D. Velluto(2), A. Tomei(1,2); (1)University of Miami, Miami, FL, USA, (2)University of Miami MSOM, Miami, FL, USA

887. Prototype Development of Macroencapsulation Device with Oxygen Generating Materials, M. Maruyama*, T. Sasaki, M. Matsumori; Hitachi, Ltd., Hitachi, Japan

Bioelectronics and Biosensors

888. Light-Controlled Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Neuromodulation and Monitoring, D. Adewole*(1,2,3), L. Struzyna(1,2,3), J. Burrell(1,2,3), K. Browne(2,3), J. Wolf(2,3), H.-C. Chen(2,3), D. Cullen(1,2,3); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Penn Medicine, Philadelphia, PA, USA, (3)CMC VA Medical Center, Philadelphia, PA, USA

889. Porous, Conductive Hydrogel Electrodes Designed to Improve the Recording Longevity of Neuroelectronic Interfaces, L. Crawford*, I. Dryg, N. Beeman, S. Perlmutter, B. Ratner; University of Washington, Seattle, WA, USA

890. 3D Printed Polypyrrole Microneedle Arrays for Electronically Controlled Drug Release, J. Huang*, J. Johnson, R. Saigal; University of Washington, Seattle, WA, USA

891. Organic, Flexible, and Biodegradable Silk Microstructures for Bioinspired Devices, V. Yadavalli*, M. Xu, S. Pradhan; Virginia Commonwealth University, Richmond, VA, USA

892. Mechanically Compliant Implants as a Strategy to Decrease Foreign Body Reaction to Nerve Interfaces, A. Carnicer-Lombarte*, D. Barone, G. Malliaras, J. Fawcett, K. Franze; University of Cambridge, Cambridge, United Kingdom

893. Localized Resveratrol Delivery Improves Recording Quality from Intracortical Microelectrodes, Y. Kim*(1,2), E. Ereifej(1,2), S. Meade(1,2), K. Chen(1,2), W. Schwartzman(1,2), H. Feng(1,2), J. Rayyan(1,2), J. Capadona(1,2); (1)Case Western Reserve University, Cleveland, OH, USA, (2)Louis Stokes Cleveland Department of Veterans Affairs Medical Cente

894. Developing a Mobile Health Solution for Treatment of Plantar Fasciitis, J. Johnson*, J. Mcgreevey, L. Schenk; Clemson, Clemson, SC, USA

895. Development of Bipolar Electrochemical Nano-Bioelectronic Systems, A. Shaw*, R. Rahman, R. Hague, F. Rawson; University of Nottingham, Nottingham, United Kingdom

Engineering Biomaterials for Translational Pulmonary Research

896. Clickable, Hybrid Hydrogels as Tissue Culture Platforms for Modeling Chronic Pulmonary Diseases in vitro, C. Petrou*(1,2), N. Darling(2), D. Bölükbas(3), D. Wagner(3), C. Magin(1,2); (1)University of Colorado, Denver, Anschutz Medical Campus, Aurora, CO, USA, (2)University of Colorado, Anschutz Medical Campus, Aurora, CO, USA, (3)Lund University, Lund, Sweden

897. Co-Culture of Lung Fibroblasts and Breast Cancer Cells in Boronic Acid-Based Hydrogels, S. Cassel*(1), M. Smithmyer(1), C. Deng(2), P. LeValley(1), B. Sumerlin(2), A. Kloxin(1); (1)University of Delaware, Newark, DE, USA, (2)University of Florida, Newark, FL, USA

From Bench-to-Bedside: Translating Biomaterials Research *BTI*

898. Manufacturing Considerations for Producing and Assessing Decellularized Extracellular Matrix Hydrogels, M. Hernandez*, G. Yakutis, K. Christman; University of California, San Diego, La Jolla, CA, USA

899. Crystallinity and Reversibility in Injectable PVA/PEG Hydrogels, V. LaMastro*, E. Brewer, A. Lowman; Rowan University, Glassboro, NJ, USA

900. Microplate Agar (MPA) - A Promising Miniaturized Protocol of the Ames Test, G. Umbuzeiro*(1,2), D. Morales(1), F. Vacchi(3), A. Albuquerque(1), H. Freeman(2); (1)FT UNICAMP, Limeira, Brazil, (2)NCSU, Raleigh, NC, USA, (3)UNICAMP, Campinas, Brazil

901. Soft Tissue Reinforcement with Poly-4-hydroxybutyrate Mesh Scaffolds for Urogynecology Applications, D. Martin*, B. Shah, D. Antonuccio, K. Guo, J. Scott, I. Toponarski, A. Ganatra, S. Rizk; Tepha, Inc., Lexington, MA, USA

902. In vitro Experimentation Elucidates Mechanisms of Reported Wound Healing Clinical Outcomes Using Amnion-Derived Fluid and Membrane Products, D. Dominguez(1), R. Audet(1), R. Diller*(1), T. Bardsley(1), R. Kellar(1,2); (1)Axolotl Biologix, Inc, Flagstaff, AZ, USA, (2)Center for Bioengineering Innovation at Northern Arizona University, Flagstaff, AZ, USA

903. Lubricant-Infused Urinary Catheters Prevent Bacterial Colonization in A Rat Model, M. Badv*(1), F. Sayed(2,3), J. Faugeroux(4), D. Behr-Roussel(4), M. Rottman(3), T. Didar(1); (1)McMaster University, Hamilton, ON, Canada, (2)Laboratoire De Microbiologie, Boulogne-Billancour, France, (3)Université de Versailles St Quentin, Paric, France, (4)Pelvipharm, Montigny-le-Bretonneux, France

904. New Technology to Reduce Complications and Procedure Time in Cranial and Spinal Surgery, P. Modak*, M. Nadig, W. Hammond, M. Jaffe, R. Russo; Endomedix, Montclair, NJ, USA

905. Development of Dual-Action Topical Therapeutics for Cytomegalovirus-Induced Hearing Loss, M. Serban*(1,2), E. Arrigali, E. Johnston(2), B. Serban(1); (1)University of Montana - BMED, Missoula, MT, USA, (2)University of Montana, Missoula, MT, USA

906. Development of an Implantable Inner Ear Corticosteroid Delivery System, E. Pierstorff*(1), W.-W. Yang(1), Y.-J.A. Chen(2), F. Kalinec(3), W. Slattery(1); (1)O-Ray Pharma, Inc, Pasadena, CA, USA, (2)House Research Institute, Los Angeles, CA, USA, (3)University of California, Los Angeles, Los Angeles, CA, USA

907. Does Annealing Improve the Interlayer Adhesion and Structural Integrity of FFF 3D printed PEEK Lumbar Spinal Cages?, C. Basgul*(1), T. Yu(1), D. MacDonald(1), R. Siskey(1,2), M. Marcolongo(1), S. Kurtz(1,2); (1)Drexel University, Philadelphia, PA, USA, (2)Exponent Inc., Philadelphia, PA, USA

908. Evaluation of Printing Parameters for Additive Manufacturing of Bioresorbable Devices, C. Culbreath*(1,2), S. Taylor(1), S. McCullen(1), O. Mefford(2); (1)Poly-Med, Inc., Anderson, SC, USA, (2)Clemson University, Clemson, SC, USA

909. Novel Technique for Creating Aligned Microfibers within 3D Printed Structures: A Preliminary Report, M.S. Taylor*, B. Gaerke; Poly-Med, Inc., Anderson, SC, USA

910. Biocompatibility of Fused Deposition Modeling 3D Printed Biomedical Devices, S. Lyu*, C. Bakken, S. Tuominen, G. Lyu, V. Bhatia, R. Lahm, E. Rankin, M. Bucheger; Medtronic PLC, Mounds View, MN, USA

Gasotransmitter Delivery from Biomaterials

911. Reduction of Biofouling and Infection of Indwelling Medical Devices via Combined Nitric Oxide (NO) Release and Antifouling Polymer Interfaces, E. Brisbois*(1), M. Chug(1), S. Hopkins(2), J. Pant(2), M. Douglass(2), C. Feit(1), H. Handa(2); (1)University of Central Florida, Orlando, FL, USA, (2)University of Georgia, Athens, GA, USA

912. Polymeric Micelle-Based Hydrogen Sulfide Donors, U. Hasegawa*(1), A. van der Vlies(2); (1)Kansas State University, Manhattan, KS, USA, (2)Kansas State University, Department of Chemistry, Manhattan, KS, USA

913. Antibacterial and Cellular Response Towards a Gasotransmitter Based Wound Dressing, J. Pant*, S. Hopkins, M. Goudie, M. Douglass, H. Handa; University of Georgia, Athens, GA, USA

Multifunctional Biomaterials: Recent Developments and Future Directions

914. Synthesis of Glycopolymers with Specificity for Bacterial Strains via Bacteria-Guided Polymerization, Y. Luo*, Y. Gu, R. Feng, G. Chen, H. Chen; Soochow University, Suzhou, China

915. Glycosylated Hydrogels for Tunable Capture and Release of Carbohydrate-Binding Proteins, J. Olguin*, M. Molinaro, G. Hudalla, A. Restuccia; University of Florida, Gainesville, FL, USA

916. Glycosaminoglycans-mimicking Polymers Conjugated Gold Nanoparticles for Promoting Neural Differentiation of Embryonic Stem Cells, L. Wang*, S. Zhang, H. Chen; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China

917. Co-assembling Tags for Modular Assembly of Glycosylated Peptide Nanomaterials, D. Seroski*, T. Roland, L. Astrab, G. Hudalla; University of Florida, Gainesville, FL, USA

918. Carbohydrate-based Biomaterial from Seafood Waste for Biomedical Applications, J. Chakravarty*(1), M.F. Rabbi(1), V. Chalivendra(1), C.-L. Yang(1), T. Ferreira(1), C. Brigham(2); (1)University of Massachusetts Dartmouth, Dartmouth, MA, USA, (2)Wentworth Institute of Technology, Boston, MA, USA

919. Identifying Small Colony Variants and Related Antimicrobial Treatments, B. Li*, J. Kang; West Virginia University, Morgantown, WV, USA

920. Molecular Engineering Strategies for Designer Polyelectrolyte Nanocomplexes, J. Ting*(1,2), H. Wu(1), S. Meng(1), A. Herzog-Arbeitman(1), M. Tirrell(1,2); (1)University of Chicago, Chicago, IL, USA, (2)Argonne National Laboratory, Lemont, IL, USA

921. Efficient capture and release of rare tumor cells using microfiber fabrics modified with multi-functional peptide, A. Yoshihara*(1), R. Sekine(1), Y. Yamada(2), M. Takai(1); (1)University of Tokyo, Tokyo, Japan, (2)Gunma Children’s Medical Center, Gunma, Japan

922. Thermoresponsive Hydrogels with Comb-Type Architecture for "Self-Cleaning" Glucose Biosensor Membranes, P. Dong*, A. Means, B. Schott, G. Coté, M. Grunlan; Texas A&M University, College Station, TX, USA

923. HDACs-targeting pH Probe for Intraoperative Detection of Metastatic Tumors and Chemotherapy, Y. Yang*, J. Ling, Y. Ling, Y. Luo; Nantong University, Nantong, China

924. Polyhydroxyalkanoates: A Family of Natural Polymers, for Medical Implant Development and Disease Modelling, P. Basnett*(1), R. Nigmatullin(1), F. Rodríguez(2), X. Mendibil(3), R. Ortiz(3), I. Quintana(3), J. Salber(4), P. Onganer(1), J. Knowles(5), I. Roy(1); (1)University of Westminster, London, United Kingdom, (2)Hospital Nacionale de Paraplejicos (SESCAM), Finca la Peraleda, Spain, (3)IK-4 Tekniker Technological Research Center, Eibar, Spain, (4)UMC Knappschaftskrankenhaus, Bochum, Germany, (5)University College London, London, United Kingdom925. Wet Spinning of Poly (4-hydroxybutyrate) to Produce Drug-loaded Fibers for Controlled Drug Delivery, B. Singhi*, E. Ford, M. King; North Carolina State University, Raleigh, NC, USA

926. Photoreactive Peptides for Micropatterning by Two Photon Photolysis, K. Michael*; University of Texas at El Paso, El Paso, TX, USA

927. Combination of Molecular Mobility of Sulfonated-Polyrotaxane and Growth Factors for Improving Hepatocyte Functions, Y. Arisaka*, N. Yui; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

928. In vivo Degradation and Host Response to Aliphatic Polycarbonates Degradable By Intra-Molecular Cyclization, B. Amsden*, S. Mohajeri; Queen's University, Kingston, ON, Canada

929. Filament Wound Collagen Sling for Treatment of Urinary Incontinence: in vivo Ovine Model, I. Isali*(1), A. Khalifa(1,2), H. Celik(3), C. Gillespie(4), R. Colbrunn(4), S. Shankar(5), K. Derwin(4), A. Hijaz(1), O. Akkus(3); (1)Case Western Reserve University & University Hospitals Cleveland Medical Center, Cleveland, OH, USA, (2)Menoufia University, Cairo, Egypt, (3)Case Western Reserve University, Cleveland, OH, USA, (4)Lerner Institute Cleveland Clinic Foundation, Cleveland, OH, USA, (5)CollaMedix Inc., Cleveland, OH, USA

930. Orthogonal Photochemistry for Wavelength-Selective Modulation of Dynamic Biomaterials, S. Adelmund*, K. Uto, P. Farahani, J. Wolfe, C. DeForest; University of Washington, Seattle, WA, USA

931. Matrices from Genetically Engineered Plant Cell Lines as Three-Dimensional Scaffolds for Cell Growth, J. Coburn*(1), N. Phan(1), T. Wright(2), J. Xu(2); (1)Worcester Polytechnic Institute, Worcester, AR, USA, (2)Arkansas State University, Jonesboro, AR, USA

932. Thermo-responsive Copolymers for Enzyme-triggered Drug Delivery and Bioresorbable Scaffolds, K. Rosas Gomez*, B. Vernon, A. Pal, K. Lein; Arizona State University, Tempe, AZ, USA

933. Novel Crosslinkers Enabling Reversal of Crosslinking with Light, H. Del Castillo*, K. Michael; University of Texas at El Paso, El Paso, TX, USA

934. Isolation of CAR-T Cells with Modified Poly(vinyl) Alcohol Membranes, B. Austin-Carter*, E. Harris, N. Comolli, J. Elmer; Villanova University, Villanova, PA, USA

935. Adaptation of Liquid Handling Robotics for High Throughput Customizable RAFT-Polymerization, M. Tamasi*, S. Kosuri, R. Upadhya, A. Gormley; Rutgers University, Piscataway, NJ, USA

936. Engineering Liquid Crystalline Polymers for Biological Applications, J. Boothby*(1), C. Ambulo(1), M. Saed(2), T. Ware(1); (1)The Univeristy of Texas at Dallas, Richardson, TX, USA, (2)University of Cambridge, Cambridge, United Kingdom

937. Regulation of Hydrogen Peroxide Generation from Mussel-inspired Adhesive via Silica Particle Incorporation, R. Pinnaratip*, R. Rajachar, B. Lee; Michigan Technological University, Houghton, MI, USA

Recent Advances in Antimicrobial and Antibiofilm Materials

938. Engineering a Zinc Phosphate Coating on Zinc for Enhanced Biocompatibility and Antibacterial Property, D. Zhu*, Y. Su, Y. Zheng, Y.-X. Qin; University of North Texas, Denton, TX, USA

939. Development of Small Animal Infection Model for Evaluating Barrier Properties of the Epidermal Seal against Infection Around the Percutaneous Implant Systems – A Pilot Study, S. Jeyapalina*(1,2), Z. Tiang(1,2), K. Bachus(2), J. Beck(2), M. Van Dyke(3), B. Bennett(1,2); (1)University of Utah, Salt Lake City, UT, USA, (2)Department of Veterans Affairs, Salt Lake City, UT, USA, (3)Virginia Tech, Blacksburg, VA, USA

940. An Alternative, Quantitative Method for Measurement of Bacterial Cell Coverage on Flat Samples Using Sem Image Analysis, M. Zurawski*, C. Scotchford, S. Atkinson, D. Grant; University of Nottingham, Nottingham, United Kingdom

941. Silver-Doped Titania Nanotubes; Processing, Characterization, and in vitro Cellular Interaction, S. Vahabzadeh*, M.K. Duvvuru; Northern Illinois University, DeKalb, IL, USA

942. 2-Heptylcyclopropane -1-carboxylic Acid Loaded Acylated Chitosan Membranes Inhibit Bacterial Biofilms, R. Awais*, Z. Harrison, B. Raji, V. Murali, J. Bumgardner, D. Baker, J. Jennings; University of Memphis, Memphis, TN, USA

943. Development of a Polydopamine Antimicrobial Coating for Marine Applications, A. Tyo*(1), S. Welch(1), P. Forooshani(1), R. Ping(1), B. Lee(1), A. Zerbini(2), J. Robbins(3), R. Rajachar(1); (1)Michigan Technological University, Houghton, MI, USA, (2)Alaska Fisheries Science Center, Seattle, WA, USA, (3)Center for Coastal Studies, Provincetown, MA, USA

944. Zinc-oxide Nanoparticles Act Catalytically and Synergistically with Nitric Oxide Donors to Enhance Antimicrobial Efficacy, P. Singha*, C. Workman, J. Pant, S. Hopkins, H. Handa; University of Georgia, Athens, GA, USA

945. Local Delivery of Diflunisal Protects Host Bone Tissue from S. Aureus Biofilm-Induced Bone Destruction, T. Spoonmore*(1), A. Hendrix(2), J. Cassat(2), S. Guelcher(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA

946. Fabrication of Cytocompatible Self-Assembling Antimicrobial Nanofibers Via Peptide Self-assembly, H. Dong*(1), D. Xu(2), W. Chen(1), W. Qiang(3); (1)University of Texas at Arlington, Arlington, TX, USA, (2)Clarkson University, Potsdam, NY, USA, (3)Binghamton University, Binghamton, NY, USA

947. Mannose Conjugated Polymer Binding in the P. Aeruginosa Biofilm, E. Limqueco*(1), D. Passos Da Silva(2), F.-Y. Su(1), C. Reichhardt(2), J. Chen(1), D. Das(1), M. Parsek(2), P. Stayton(1), D. Ratner(1); (1)University of Washington, Seattle, WA, USA, (2)University of Washington Microbiology, Seattle, WA, USA

948. Smart Antibacterial Surfaces Fabricated via Layer-By-Layer Deposition and Host-Guest Interaction, T. Wei*, W. Zhan, Q. Yu, H. Chen; Soochow University, Suzhou, China

949. Quantifying the Natural Antimicrobial Properties of N-halamine-based Cotton Against MRSA, T. Hoekstra*(1), Y. Deng(1), Y. Sun(2); (1)University of South Dakota, Sioux Falls, SD, USA, (2)University of Massachusetts Lowell, Lowell, MA, USA

950. A Novel Highly-Adherent Polymer Coating to Prevent Orthopedic Pin-site Infections., M. Bredikhin*(1), C. Gross(2), I. Luzinov(1), A. Vertegel(1); (1)Clemson University, Clemson, SC, USA, (2)Medical University of South Carolina, Charleston, SC, USA

951. Polymer-Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultra-Thin Universal Binary Anti-Biofilm Coating with Long-Term Activity, Y. Mei*, K. Yu, D. Lange, J. Kizhakkedathu; University of British Columbia, Vacnouver, BC, Canada

952. Metallic Implant Surface Modification Process for Enhanced Biofilm Resistance, J. DesJardins*(1), C. Bales(1), S. Helms(1), L. O'Neill(2); (1)Clemson University, Clemson, SC, USA, (2)TheraDep, San Jose, CA, USA

953. A Substrate-Independent Smart Antibacterial Surface for the Rapid and Effective Killing and Release of Adherent Bacteria, Y. Qu*(1), T. Wei(1), J. Zhao(2), S. Jiang(1), P. Yang(2), Q. Yu(1), H. Chen(1); (1)Soochow University, Suzhou, China, (2)Shaanxi Normal University, Xi'an, China

954. Addressing the Challenges of Bioactive and Antibacterial Thin Film Formation Using the Spin Coating Technique, L. Soule*, X. Chatzistavrou; Michigan State University, East Lansing, MI, USA

955. A Murine Model of Cutaneous Aspergillosis for Evaluation of Biomaterials-based Local Delivery Therapies, A. Tatara*(1,2,3), E. Watson(1), N. Albert(3), P. Kontoyiannis(1), D. Kontoyiannis(3), A. Mikos(1); (1)Rice University, Houston, TX, USA, (2)Massachusetts General Hospital, Boston, MA, USA, (3)The University of MD Anderson Cancer Center, Houston, TX, USA

Targeted and Stimuli-Responsive Biomaterials

956. Fucoidan-coated Fibrous Mesh as a Skin Patch to Treat Melanoma, C. Oliveira(1,2), N. Neves(1,2,3), R. Reis*(1,2,3), T. Silva(1,2), A. Martins(1,2); (1)3B´s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Guimarães, Portugal, (2)ICVS/3B’s – PT Government Associate Laboratory, Braga, Portugal, (3)The Discoveries Centre for Regenerative and Precision Medicine, Guimaães, Portugal

957. Neutralization of Pro-inflammatory Cytokines by Intra-articular Injection of Biofunctionalized Nanoparticles as an Advanced Treatment for Osteoarthritis, A. Lima(1,2), D. Amorim(2,3), I. Laranjeira(2,3), A. Almeida(2,3), H. Ferreira(1,2), F. Pinto-Ribeiro(2,3), N. Neves*(1,2,4); (1)3B's Research Group, Guimarães, Portugal, (2)ICVS/3B’s–PT Government Associate Laboratory, Braga, Portugal, (3)Life and Health Sciences Research Institute (ICVS), Braga, Portugal, (4)The Discoveries Centre for Regenerative and Precision Medicine, Guimarães, Portugal

958. Stimulus-Responsive Drug Delivery from PEGylated Polyvinylidene Fluoride- Polypyrrole Core-Shell Fibers, S. Miar*(1,2), F. Acosta(1,2), T. Guda(1,2); (1)University of Texas at San Antonio, San Antonio, TX, USA, (2)University of Texas Health Center at San Antonio, San Antonio, TX, USA

959. Redox-Active Layer-by-Layer Coatings Containing Cerium Oxide Nanoparticles for the Encapsulation of Cellular Spheroids, N. Abuid*, K. Gattas-Asfura, C. Stabler; University of Florida, Gainesville, FL, USA

960. Light-Induced, Surface Mediated Gene Transfection on TiO2 Nanorods / Collagen / Au Composite Coatings, K. Cheng*, W. Weng, X. He; Zhejiang University, Hangzhou, China

961. Chondrogenic Inductive Nanofibrous Mesh Biofunctionalized with Human Fibronectin, M. Casanova(1,2,3), R. Reis(1,2,3), A. Martins(1,2), N. Neves*(1,2,3); (1)3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco – Guimarães, Portugal, (2)ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal, (3)The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Barco - Guimarães, Portugal

962. Effect of CAD/CAM Dental Materials Composition on the Adhesion to the Cement Interface, H.G. Deery*, E. Teixeira, S. Armstrong, C. de Mattos Pimenta Vidal; University of Iowa, Iowa City, IA, USA

963. Graphene oxide-bone morphogenic protein2 complex coating by facile in-situ deposition, E.-J. Lee*; Dankook University, Cheonan, Republic of Korea

964. A Novel Chromogenic β-Lactamase Substrate for Diagnostic Biomaterials, H. Safford*, D. Alkekhia, S. Shukla, A. Shukla; Brown University, Providence, RI, USA

965. Tailoring Gelation and Mechanical Properties of Fibrin-Based Extracellular Matrix Using Stimulus-Responsive Poly(Lactic-co-Glycolic Acid) Microgelator, Y.-T. Hong*, H. Kong; University of Illinois Urbana-Champaign, Urbana, IL, USA

966. An Avidin-Biotin Nanoparticle System for Detecting and Treating Inflammatory Diseases, M.K. Khang*, J. Zhou, L. Tang, Y. Huang, A. Hakamivala; University of Texas at Arlington, Arlington, TX, USA

967. Reactive Oxygen Species Sensitive Polymeric Micelles for Anti-Cancer Drug Delivery, E. Radaha*, A. van der Vlies, U. Haegawa; Kansas State University, Manhattan, KS, USA

968. Direct Removal of Circulating Leukemia Cells by Magnetic Hyperthermia, H. Al Faruque*, E.-S. Choi, J.-H. Kim, E. Kim; Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea

969. Evaluation of the Properties of Mechanically Stretched Poly (N-isopropylacrylamide) Gel Grafted Polydimethylsiloxane Surfaces, Y. Akiyama*(1), N. Takeda(2), M. Yamato(1), T. Okano(1); (1)Tokyo Women’s Medical University, Tokyo, Japan, (2)Waseda University, Tokyo, Japan

970. In situ Formation of Fluorescent Extracellular Vesicles (EVs), M. Chen*(1), Y. Xiang(1), A. Waspe(1,2), C. Heyn(1,3,4), J. Rutka(1,2), J. Drake(1,2), N. Matsuura(1); (1)University of Toronto, Toronto, ON, Canada, (2)The Hospital for Sick Children, Toronto, ON, Canada, (3)Sunnybrook Research Institute, Toronto, ON, Canada, (4)Sunnybrook Health Sciences Centre, Toronto, ON, Canada

971. pH-Responsive Polymeric Nanoparticles for the Oral Delivery of High Isoelectric Point Therapeutic Proteins, H. Oldenkamp*(1,2), M. Koetting(1,2), N. Peppas(1,2,3,4,5,6); (1)McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA, (2)Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA, (3)Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA, (4)Department of Surgery and Perioperative Care, Dell Medical School, University of Texas at Austin, Austin, TX, USA, (5)Department of Pediatrics, Dell Medical School, University of Texas at Austin, Austin, TX, USA, (6)Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, University of Texas at Austin, Austin, TX, USA

972. Removal of trimethylamine N-oxide during hemodialysis using molecularly imprinted polymers, R. Tang*, B. Ratner; University of Washington, Seattle, WA, USA

Nanomaterials SIG

973. Improved Neural Differentiation of Stem Cells via Magnetic Iron Oxide Nanoparticles under Magnetic Field, R. Dai*, Y. Pan, H. Chen; Soochow University, SuZhou, China

974. Enhancement of Antimicrobial Activity of Silver Nanoplates by Gold Coating and Control of the Activity by Light Irradiation, T. Niidome*(1), K. Kyaw(1,2), H. Ichimaru(1), A. Harada(1), Y. Miyazawa(3), M. Daigou(3); (1)Kumamoto University, Kumamoto, Japan, (2)Yangon Technological University, Yangon, Myanmar, (3)Dai Nippon Toryo Co., Ltd., Otawara, Japan

975. Research of the Role of MicroRNAs in Cytotoxicity Induced by Silver Nanoparticles, Y. Huang*, X. Lü, X. Lü; Southeast University, Nanjing, China

976. Effect of Laser Pulse Width on Bioactivity of Titania Nanofibrous Structures Deposited on Glass Substrate via High Intensity Laser Induced Reverse Transfer Method (HILIRT), A. Kiani*(1), N. Safaie(1), M.-H. Beigi(2), M.-H. Nasr-Esfahani(2); (1)University of Ontario Institute of Technology (UOIT), Oshawa, ON, Canada, (2)Royan Institute for Biotechnology, ACECR, Isfahan, Islamic Republic of Iran

977. Engineering Antibacterial Nanosurfaces for Clinical Implementation, J. Moxley*, P. Ghannadian, T. Webster; Northeastern University, Boston, MA, USA

978. Mass Production of Biocompatible Graphene Using Silk Nanofibers, X. Zhang*, Q. Lu; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China

979. Green Synthesis of a Synergetic Structure of Tellurium Nanowires and Metallic Nanoparticles for Biomedical Applications, A. Vernet*, D. Medina, B. Zhang, T. Webster; Northeastern University, Boston, MA, USA

980. Group Distribution: An Ignored Determinant for Silk Chemical Modification, Y. Hang*(1), Q. Lu(2), H. Chen(1); (1)College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China, (2)National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China

981. Influences of Material Factors on the Anti-Melanoma Effects of Hydroxyapatite Nanoparticle, X. Zhu*, H. Wu, X. Yang, X. Zhang; National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China

982. Engineering TiO2 Nanotube Growth on Titanium Implant to Enhance its Biotribological Performance & Biocorrosion-resistance, J. Luo*(1), S. Ma(2), S. Ajami(1), F. Zhou(2), C. Liu(1); (1)University College London, London, United Kingdom, (2)Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China

983. NIR-mediated Spatiotemporal Control of Stem Cell Fate Using Multifunctional Upconversion Nanoparticles, Y. Zhang*, K.-B. Lee; Rutgers University, Piscataway, NJ, USA

Seeing More Clearly: Nanoparticle Imaging Probes in Biomedicine

984. Predicting Rupture Potential of Abdominal Aortic Aneurysms with Gold Nanoparticles Targeting to Degraded Elastin in an Angiotensin Ii Induced Mouse Model, X. Wang*(1), B. Lane(2), J. Eberth(2), S. Lessner(2), N. Vyavahare(1); (1)Clemson University, Clemson, SC, USA, (2)University of South Carolina, Columbia, SC, USA

985. Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography, Y. Dong*(1), M. Hajfathalian(2), J. Hsu(1), P. Naha(2), J. Kim(1), P. Chhour(2), P. Maidment(2), H. Litt(2), D. Cormode(1,2); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Hospital of the University of Pennsylvania, Philadelphia, PA, USA

986. Material Decomposition of Elemental Ca and P Using Photon-Counting Spectral Computed Tomography, T. Curtis*, R. Roeder; University of Notre Dame, Notre Dame, IN, USA

987. The Intracellular Interaction of HA-based Nanocrystals with Uniform Shape and Traceable Fluorescence, X. Li*(1), H. Chen(2), W. Li(1); (1)Sichuan University, Chengdu, China, (2)Peking University, Beijing, China

988. Biodistribution of Cancer Stem Cells Targeting Nanoparticle Image Contrast Agents and It’s Implications in Early Diagnosis, P. Nallathamby*(1), K. Cowden Dahl(2), R. Roeder(1); (1)University of Notre Dame, Notre Dame, IN, USA, (2)Indiana University School of Medicine - South Bend, South Bend, IN, USA

989. Tumor Targetable High-field MRI T1 Contrast Conjugates With Gd(III)-chelate Complexes and Protein Cage Nanoparticles, H. Kim*, S. Jin, H. Choi, Y. Bae, M. Kang, H. Cho, S. Kang; UNIST, Ulsan, Republic of Korea

990. Optimization of Energy Thresholds for Multi-Contrast Imaging in Photon-Counting Spectral Computed Tomography, T. Curtis*, R. Roeder; University of Notre Dame, Notre Dame, IN, USA

991. Contrast-Enhanced Mammographic Detection of Breast Microcalcifications Using Targeted Gold Nanoparticles, T. Finamore*, E. Gies, T. Vargo-Gogola, R. Roeder; University of Notre Dame, Notre Dame, IN, USA

992. Radiographic Detection Limits for HER2+ Breast Cancer Cells Immunotargeted by Gold Nanoparticles, T. McGinnity*(1,2), T. Curtis(1), T. Vargo-Gogola(2,3), R. Roeder(1,2); (1)University of Notre Dame, Notre Dame, IN, USA, (2)Harper Cancer Research Institute, South Bend, IN, USA, (3)Indiana University School of Medicine - South Bend, South Bend, IN, USA

993. Evaluation of Quantum Dots as Marker for Her2-Positive Breast Cancer Cells, A. Frank-Kamenetskii*, A. Thomson, L. Pasig, M. Kouame, M. Hedge, R. Abdel-Tawab, W. Ashley, V. Reukov; Clemson University, Clemson, SC, USA

Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering

994. Liquid Crystalline Biomaterials with Shape Memory Properties Synthesized using Click Chemistry, K. Burke*, Y. Wang, S. Wimberley; University of Connecticut, Storrs, CT, USA

995. Poly(ethylene glycol) Click Hydrogels with Embedded Sensing Microdomains for a Long-term, Implantable Biosensor, V. Baldock*, F. Jivan, D. Alge, M. McShane; Texas A&M University, College Station, TX, USA

996. Supramolecular Hydrogels Fabricated from Co-assembling Peptides as Locally-injectable Biomaterials, B. Soto-Morales*, G. Hudalla; University of Florida, Gainesville, FL, USA

997. Supramolecular Assembly of Electrospun Hydrogel Nanofibers for Mimicking Fibrous Tissue Architecture, B. Miller*(1), O. Nicholas(1), A. Jackson(2), C. Highley(1,3), S. Caliari(1,3); (1)1. University of Virginia, Charlottesville, VA, USA, (2)3. George Mason University, Fairfax, VA, USA, (3)2. University of Virginia, Charlottesville, VA, USA

998. Development of Therapeutic Vaccine by Antigen Presenting Cells Targeting Self-Assembled Nanogel, R. Miura*, S.-i. Sawada, Y. Sasaki, K. Akiyoshi; Graduate school of Engineering, Kyoto University, Kyoto, Japan

999. Relating Chemical and Physical Properties of Oligonucleotide Polyelectrolyte Complex Micelles, A. Marras*(1,2), J. Vieregg(1,2), J. Ting(1,2), M. Tirrell(1,2); (1)University of Chicago, Chicago, IL, USA, (2)Argonne National Laboratory, Lemont, IL, USA

1000. Size, Charge, and Adjuvant Incorporation Impact Peptide Amphiphile Micelles Vaccine Bioactivity, R. Zhang*, B. Rygelski, J. Smith, X. Wang, B. Allen, J. Kramer, B. Ulery; University of Missouri, Columbia, MO, USA

1001. Applications of self-assembling ultrashort peptides in bionanotechnology, M. Ni*(1,2), S. Zhuo(2); (1)Yachay Tech University, San Miguel de Urcuquí, Ecuador, (2)Fujian Normal University, Fuzhou, China

Ophthalmic Biomaterials SIG

1002. Characterization of Silk-hyaluronic Acid Hydrogels as Vitreous Humor Substitutes, N. Raia*, C. Ghezzi, D. Kaplan; Tufts University, Medford, MA, USA

1003. Nanofiber-Reinforced Hydrogels for the Stabilization of Open Globe Injuries, L. Costella*(1), L. Woodard(1), K. Broderick(1), A. Eiseman(2), C. Tison(1); (1)Luna Innovations Incorporated, Charlottesville, VA, USA, (2)Medical University of South Carolina, Charleston, SC, USA

1004. Development of a Benchtop Corneal Puncture Model Suitable for Testing Biomaterial Therapeutics, E. Snider*, J. Acevedo, P. Edsall, B. Lund, D. Zamora; United States Army Institute of Surgical Research, San Antonio, TX, USA

1005. Evaluation of Semi-Interpenetrating Network for Treating Traumatic Optic Neuropathy, A. Soltisz*, S. Thobe, M. Ruzga, M. Reilly, K. Swindle-Reilly; The Ohio State University, Columbus, OH, USA

1006. Study on Contact Lens for Blocking Blue Light, J. Lee*(1), S. An(1,2), H. Choi(1), J.K. Kim(1); (1)Inje University, Gimhae, Republic of Korea, (2)Envoy Vision, Gimhae, Republic of Korea

1007. New Routes to Mucoadhesive Block Copolymer Micelles for Ocular Drug Delivery, T. Rambarran*, H. Sheardown; McMaster University, Hamilton, ON, Canada

1008. Effect of Multipurpose Care Solutions Upon Physical Dimensions of Silicone Hydrogel Contact Lenses, D. Zhu*(1,2), S. Smith(1,2), D. Pierre(1,2), J. Gilbert(1,2), J. Chinn(3); (1)Clemson University, Clemson, SC, USA, (2)Medical University of South Carolina, Charleston, SC, USA, (3)J Chinn LLC, Lafayette, CO, USA

1009. Engineering Injectable Synthetic ECM-Based Hydrogel as Vehicles for Retinal Progenitor Cells Transplantation, J. Kundu*(1), P. Zhao(1), A. Desai(1), M. Rezaeeyazdi(1), S. Bencherif(1), M. Young(2), J. Monaghan(1), S.-Y. Kim(3), R. Linhardt(3), R. Carrier(1); (1)Northeastern University, Boston, MA, USA, (2)Schepens Eye Research Institute, Boston, MA, USA, (3)Rensselaer Polytechnic Institute, Troy, NY, USA

Orthopedic Biomaterials SIG

1010. High Adhesiveness and Hardness Hydroxyapatite, Y. Kushiki*, S. Minami, Y. Tsumura, A. Bando, N. Kitamura; Tomita Pharmaceutical Co.,Ltd., Naruto, Japan

1011. Advanced Control of Hydroxyapatite/β-TCP Ratio in Fiber, Y. Kushiki*, Y. Konishi, D. Miyagi, Y. Tsumura, N. Kitamura; Tomita Pharmaceutical Co.,Ltd., Naruto, Japan

1012. Titanium Anodization; Effects of Chemistry and in vitro Interaction with Bone Marrow Stromal Cells, W. Han*(1), M.K. Duvvuru(2), S. Vahabzadeh(2), S. Elsawa(1); (1)University of New Hampshire, Durham, NH, USA, (2)Northern Illinois University, DeKalb, IL, USA

1013. Glycosaminoglycan Incorporation into Particle-Based Hydrogels for Enhanced Articular Cartilage Regeneration, B. Pfaff*, N. Cornell, P. Cottler, C. Schaeffer, B. DeGeorge, D. Griffin; University of Virginia, Charlottesville, VA, USA

1014. Modeling and Characterization of Porous Tantalum (Ta) Scaffolds, S.K. Mamidi*(1), B.R. Golla(2), V.R. S(2), M.A. S(2), A. Yadav(2), S.C. T D(2), S. K(2,3), M. T Mathew(1); (1)University of Illinois at Chicago, College of Medicine, Rockford, IL, USA, (2)National Institute of Technology, Warangal, India, (3)Metallurgical Research Laboratory, Hyderabad, India

1015. Collagen Hydrogel Models for Investigating Macrophage Inflammatory Response to Wear Particles, P. Turner*(1,2), E. Sussman(2), J. Stegemann(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)US Food and Drug Administration, White Oak, MD, USA

1016. Injectable Gelatin Microcarriers for Osteogenic Induction of MSCs for Bone Regeneration, C. Nweke*, R. T. Annamalai, J. Stegemann; University of Michigan, Ann Arbor, MI, USA

1017. Engineered Bio-composite Scaffold with Controlled Magnesium Ion Release for Bone Defect Repairing, J. SHEN*(1), K.W.K. YEUNG(1,2); (1)The University of Hong Kong, Hong Kong, Hong Kong, (2)The University of Hong Kong Shenzhen Hospital, Shenzhen, China

1018. Biological and Corrosion Behavior of 3D Printed Titanium Alloy for Biomedical Application, D. Morris*(1,2), D. Bijukumar(1), E. Ceppi(1), P. Tsai(3), M. Wu(4), A. Orias(5), M. Mathew(1,5); (1)University of Illinois-College of Medicine at Rockford, Rockford, IL, USA, (2)University of Alabama, Tuscaloosa, AL, USA, (3)Industrial Technology Research Institute, Chutung, Taiwan, (4)Taipei Medical University Hospital, Taipei, Taiwan, (5)Rush University Medical Center, Chicago, IL, USA

1019. Analgesic-Eluting UHMWPE Promises Antimicrobial Prophylaxis After Primary Arthroplasty, D. Gil*(1,2), S. Grindy(1,2), O. Muratoglu(1,2), H. Bedair(1,2), E. Oral(1,2); (1)Massachusetts General Hospital, Boston, MA, USA, (2)Harvard Medical School, Boston, MA, USA

1020. Analgesic-Loaded UHMWPE Can Improve the Efficacy of Antibacterial Therapy for Prosthetic Joint Infections, D. Gil*(1,2), S. Grindy(1,2), K. LaPlante(3,4,5), K. Daffinee(4), O. Muratoglu(1,2), H. Bedair(1,2), E. Oral(1,2); (1)Massachusetts General Hospital, Boston, MA, USA, (2)Harvard Medical School, Boston, MA, USA, (3)University of Rhode Island, Kingston, RI, USA, (4)Providence Veterans Affairs Medical Center, Providence, RI, USA, (5)Brown University, Providence, RI, USA

1021. Establishing a Periprosthetic Infection Model in Rats, E. Oral*(1,2), Y. Xiao(1), W. Sabuhi(1), C. Leape(1), Y. Fan(1), D. Gil(1,2), O. Muratoglu(1,2), J. Collins(2,3), M. Randolph(1,2); (1)Massachusetts General Hospital, Boston, MA, USA, (2)Harvard Medical School, Boston, MA, USA, (3)Brigham and Women's Hospital, Boston, MA, USA

1022. Injectable Chemokine Loaded Fibrin Gel for Glenoid Labrum Tear Repair and Regeneration, L. Tang*, S. Li, J. Zhou, J. Borrelli; University of Texas at Arlington, Arlington, TX, USA

1023. Mechanical Compression Improves Decellularization of Intact Intervertebral Disc Xenografts, V. Casler*, A. Garon, M. Krussig, M. Namiranian, J. Walters, J. Mercuri; Clemson University, Clemson, SC, USA

1024. 3D Printing of Poly Lactic Acid (PLA)/nano-hydroxyapatite (HA) Composites for Bone Tissue Engineering, H.-D. Jung*, J. Lee, T.-S. Jang; Korea Institute of Industrial Technology, Incheon, Republic of Korea

1025. Mechanical Evaluation of Woven Collagen Patch for Rotator Cuff Tendon Repair, Y. Huang*(1), Y. Xie(1), M. King(1,2); (1)Wilson College of Textiles, North Carolina State University, Raleigh, NC, USA, (2)Donghua University, Shanghai, China

1026. The Effect of Autoclaving on Rheological and Mechanical Properties of Thermogelling Chitosan-Based Nanocomposite Hydrogel, S.m. Latifi*, C. Tang, H.J. Donahue; Virginia Commonwealth University, Richmond, VA, USA

1027. Injectable Biodegradable Elastomer to Aid in Healing of Bone Fractures, J. Sanabria*, S. Huddleston, G. Ameer; Northwestern University, Evanston, IL, USA

1028. Investigation into Soft Tissue Micro-Tearing and Repair Mechanisms as it Relates to Sports Injuries, O. Newkirk*, M. Maggio, M. Judge, A. Seilkop, K. Lindsey, A. Santore, M. Hermanns, E. Caruso, D. Dean; Clemson University, Clemson, SC, USA

1029. Serioss: A Bone Graft Substitute with Autograft like Properties, S. Shukla*(2), A. Nisal(1), R. Deshpande(2), S. Salunke(2); (1)CSIR National Chemical Labarotory, Pune, India, (2)BiolMed Innovations Private Limited, Pune, India

1030. Impacts of Bone Scaffold Architecture on Vascular Network Development, C. Perez*, A. Boehme, F. Acosta, S. Montelongo, C. Rathbone, J. Ong, T. Guda; University of Texas at SAn Antonio, San Antonio, TX, USA

Protein and Cells at Interfaces SIG

1031. PAMA-Arg Brush-Functionalized Magnetic Nanocomposites for Phosphorylated Biomolecule Enrichment, F. Lan*, B. Luo, Y. Wu; Sichuan University, Chengdu, China

1032. Antibody-Armed Platelets for Regenerative Targeting of Endogenous Stem Cells, z. Li*(1,2), S. Hu(1,2), K. Huang(1,2), T. Su(1,2), K. Cheng(1,2); (1)North Carolina State University and the University of North Carolina at Chapel-Hill, Raleigh, NC, USA, (2)North Carolina State University, Raleigh, NC, USA

Developing Better Biomaterials: Advances in Technologies and Understanding of Surface Modification

1033. Titanium with Nanotopography Induces Osteoblast and Inhibits Osteoclast Differentiation, H. Lopes*(1), R. Bighetti(1), B. Poker(1), L. Castro-Raucci(2), E. Ferraz(3), A. Souza(1), G. Freitas(1), A. Rosa(1), M. Beloti(1); (1)School of Dentistry of Ribeirão Preto, University of Sao Paulo, Ribeirao Preto, Brazil, (2)School of Dentistry, Ribeirao Preto - Unaerp, Ribeirao Preto, Brazil, (3)School of Dentistry, University of Sao Paulo, Sao Paulo, Brazil

1034. Switching Biological Functionalities of PDMS-based Microfluidic Systems, S. Li*, X. Liu, H. Chen; Soochow University, Suzhou, China

1035. Resistance to Protein Adsorption and Cell Adhesion on the Surface Immobilized with Oligo-Peptide Mimicking Collagen Backbone Structure, S. Kakinoki*, Y. Noguchi, Y. Hirano; Kansai University, Osaka, Japan

1036. Sol-gel Based Hyaluronic Acid-Silica Nanocomposite with Lubricative Performance for Intravascular Guidewire, C. Hwang*, J. Kim, S. Park, H.-E. Kim, S.-H. Jeong; Seoul National University, Seoul, Republic of Korea

1037. Evaluation of immune response of macrophages using bioactive nanotopography surfaces on Titanium alloy (Ti6Al4V) designed by Directed irradiation synthesis, A. Civantos*, A. Mesa, C. Jaramillo, A. Barnwell, A. Shetty, J.P. Allain; University of Illinois at Urbana Champaign, Urbana, IL, USA

1038. Anodized/etched and DIS treated Ti surfaces to promote bone formation, A. Mesa*(1,2), R. Montes(2), E. Patiño(2), J.F. Alzate(2), A. Civantos(1), N. Balcázar(2), J.J. Pavón(2), J.P. Allain(1); (1)University of Illinois at Urbana-Champaign, Urbana, IL, USA, (2)University of Antioquia, Medellín, Colombia

Surface Characterization and Modification SIG

1039. A Novel Zwitterionic Polymer for Surface Modification of Polypropylene: Synthesis, Surface Characterization, Antimicrobial Adhesion and Hemocompatibility, J.-C. Lin*(1), C.-S. Hung(1), C.-H. Cheng(2); (1)National Cheng Kung University, Tainan, Taiwan, (2)Chang Gung University, Chang Gung Memorial Hospital, Kwei-Shan, Taoyuan, Taiwan

1040. A Quaternary Ammonium Bromide-Containing Polymer for Polyurethane Surface Modification, R. Almousa*, L. Howard, D. Xie; Indiana University-Purdue University at Indianapolis, Indianapolis, IN, USA

1041. Improvement of Surface Adhesion of Electrosprayed Chitosan Coatings to Titanium Substrates, B. Watson*, R. Gopalakrishnan, T. Fujiwara, J. Bumgardner; University of Memphis, Memphis, TN, USA

1042. Surface Energy of Albumins and the Effect of Relative Humidity, D. Burnett*(1), V. Karde(2), J. Heng(2); (1)Surface Measurement Systems, Allentown, PA, USA, (2)Imperial College London, London, United Kingdom

1043. Characterization of Bioglass Deposited on Porous TiO2 Produced by Plasma Electrolytic Oxidation, P. Soares*(1), L. Bemben(1), D. Weiss(1), R. Sabino(2), K. Popat(2); (1)Pontificia Universidade Catolica do Parana, Curitiba, Brazil, (2)Colorado State University, Fort Collins, CO, USA

1044. Label-free 3D Imaging Surface Modifications within Biomaterial Scaffolds using Time-of-Flight Secondary Ion Mass Spectrometry, M. Taylor*, D. Graham, L. Gamble; The University of Washington, Seattle, WA, USA

3D Bioprinting Applications in Tissue Engineering and Regenerative Medicine

1045. An Innovative Cell-laden a-TCP/collagen Scaffold Fabricated Using a Two-step Printing Process for Potential Application in Regenerating Hard Tissues, W. Kim*(1), J. Lee(1), M. Yeo(1), J. Lee(1), S. Chae(1), J. Kim(1), H.-S. Yun(2), G. Kim(1); (1)Sungkyunkwan University (SKKU), Suwon-si, Republic of Korea, (2)Korea Institute of Materials Science (KIMS), Changwon-si, Republic of Korea

1046. Cell-laden Prionace Glauca Skin Collagen-based 3D Printed Scaffolds for the Engineering of Mineralized Tissues, G. Diogo*(1,2), C. Marques(1,2), R. Pérez-Martin(3), R. Pirraco(1,2), C. Sotelo(3), R. Reis(1,2,4), T. Silva(1,2); (1)3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, Guimarães, Portugal, (2)ICVS/3B’s - PT Government Associate Laboratory, Braga, Portugal, (3)Instituto de Investigaciones Marinas (CSIC), Vigo, Spain, (4)The Discoveries Centre for Regenerative and Precision Medicine, Guimarães, Portugal

1047. Novel 3D Printed Poly(ethylene glycol) Dimethacrylate Based Photocurable Scaffolds for Bone Regeneration: in vitro and in vivo Evaluation, J. Unagolla*, B. Gaihre, C. Jayasuriya; University of Toledo, Toledo, OH, USA

1048. Fabrication of m13-Bacteriophage-Conjugated Alginate Scaffold for Hard Tissue Engineering, L. JaeYoon*, K. GeunHyung; Sungkyunkwan University, Suwon-si, Republic of Korea

1049. Aligned Microfibrous Bundle Structure Fabricated Using Electrohydrodynamic Jet Printing and Cell Printing Process, M. Yeo*, W. Kim, J. Lee, J. Lee, S.J. Chae, G.H. Kim; Sungkyunkwan University, Suwon, Republic of Korea

1050. A Bioengineered 3D Printed Calciumalkaliorthophosphate-based Bone Graft Facilitates Repair of Critical-Size Segmental Discontinuity Bone Defects in vivo, C. Knabe*(1), M. Stiller(1), M. Kampschulte(2), B. Peleska(3), R. Gildenhaar(4), G. Berger(4), A. Rack(5), J. Guenster(4), U. Linow(4), D. Adel-Khattab(6); (1)Philipps University Marburg, Marburg, Germany, (2)Justus Liebig University of Giessen, Giessen, Germany, (3)Philipps University, 35039 Marburg, Marburg, Germany, (4)Federal Institute for Materials Research and Testing, Berlin, Germany, (5)European Synchrotron Radiation Facility, Grenoble, France, (6)Ain Shams University, Cairo, Egypt

1051. Hierarchical 3D Scaffolds for Bone Tissue Engineering: Full Factorial Design and Dynamic Cell Culture, A. Yousefi*(1), S. Koo(1), J. Powers(2), J. Liu(1), K. Sampson(1), P. James(2), J. Zhang(3); (1)Miami University - 1, Oxford, OH, USA, (2)Miami University - 2, Oxford, OH, USA, (3)Miami University - 3, Oxford, OH, USA

1052. Rheological Characterization of Bioinks for Cell-based 3D Bioprinting, M. Elizondo*(1,2), G. Gillispie(2), S. Lee(2), J. Yoo(2), A. Atala(2); (1)Rice University, Houston, TX, USA, (2)Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA

1053. Bioprinting of Three-Dimensional Microtissues to Evaluate Adipocyte-Breast Cancer Cell Interactions, S. Chaji*, J. Alsaleh, C. Gomillion; University of Georgia, Athens, GA, USA

1054. 3D Printing Technique to Produce Biomaterial Scaffolds with Tailored Hierarchical Porosity, Z. Wang*, S. Florczyk; University of Central Florida, Orlando, FL, USA

1055. Thermal Inkjet Printed Endothelial Cells Cause Microvasculature Formation in Host Tissues via Heat shock Protein Induced VGEF release, T. Boland*(1), B. Oropeza(1), L. Solis(1), M. Yanez(2); (1)The University of Texas at El Paso, El Paso, TX, USA, (2)University of South Carolina, Columbia, SC, USA

1056. 3D-printing patterned biocompatible hydrogels to promote angiogenic sprouting, C. Pan*, G. Calderon, S. Paulsen, D. Sazer, B. Grigoryan, J. Miller; Rice University, Houston, TX, USA

1057. Development and evaluation of a perfusable dual hydrogel system for prevascularization in tissue engineering, S. Kim*, C.-C. Pan, Y. Yang; Stanford University, Stanford, CA, USA

1058. Three-dimensional Extrusion Bioprinting of Self-healing Hydrogel for Tissue Regeneration, K.Y. Lee*, S.W. Kim, H.H. Roh, H.S. Kim; Hanyang University, Seoul, Republic of Korea

1059. Architectures of 3D Printed, Sintered β –TCP Scaffolds Optimized for Strength and Permeability, G. Chiou*(1,2), S. Montelongo(1,2), S. Miar(1,2), J. Ong(1,2), T. Guda(1,2); (1)University of Texas at San Antonio, San Antonio, TX, USA, (2)UT Health San Antonio, San Antonio, TX, USA

3D Printing and Bioengineered Tissues for In Vitro Modeling of Disease Process and Drug Screening

1060. “Cancer Extracellular Vesicles Derived Supported Lipid Bilayer as a Platform for Cell Culture to Understand Interactions between Adipose Stem Cells and Oncogenic Extracellular Vesicles ”, J. Uribe*, H.-Y. Liu, C. Fischbach, S. Daniel; Cornell University, Ithaca, NY, USA

1061. Digitization and Solid Deposition for Layer-By-Layer 3D Biofabrication of Varying Bone Densities, T. Burg*, K. Burg, J. Williams, N. Morris; University of Georgia, Athens, GA, USA

1062. Comparison of Human and Porcine Pancreatic Decellularized Extracellular Matrix Bioink Using Proteomic Approaches, M. Kim*(1), J. Kim, I.K. Shim(2), S.C. Kim(2), J. Jang(3); (1)POSTECH, Pohang, Republic of Korea, (2)University of Ulsan College of Medicine, Seoul, Republic of Korea, (3)POSTECH, Pohang, Republic of Korea

1063. 3D Printable Polydimethylsiloxane for Hybridized Scaffolding in Building Biomimetic Tissue, M. Heon*, D. Aks, M. He; University of Kansas, Lawrence, KS, USA

1064. Fabrication of Artificial Skin Model Using Decellular Extracellular Matrix Bioink, M.-J. Kim*(1), I. Jang(1), J.-H. Shim(2), W.-S. Yun(2), S. Jin(2); (1)Research Institute of T&R Biofab Co. Ltd., Siheung, Republic of Korea, (2)3D Bioprinting Research Center, Siheung, Republic of Korea

1065. Printing Mechanically Tunable Cardiac Decellularized Extracellular Matrix Bioinks for Modeling Cardiac Fibrosis, Y.J. Shin*, R. Shafranek, J. Tsui, A. Nelson, D.-h. Kim; University of Washington, Seattle, WA, USA

Advanced Fabrication Approaches for Multiscale Tissue Engineering

1066. High and Low Perfusion Microvascular Breast Tumor Mimetic Chip for Anti-Cancer Drug Screening, B. Anbiah*, I. Hassani(1), N. Habbit(1), R. Arnold(1), B. Prabhakarpandian(2), E. Lipke(1); (1)Auburn University, Auburn, AL, USA, (2)Center for Drug Research Corporation, Huntsville, AL, USA, Auburn University, Auburn, AL, USA

1067. A Scalable Xeno-Free Microcarrier-based Suspension Bioreactor System for Biomanufacturing of Human Mesenchymal Stem Cells (hMSCs) for Regenerative Medicine, J. Lembong*, R. Kirian, D. Wang, J. Rowley, T. Ahsan; RoosterBio, Frederick, MD, USA

1068. Three-Dimensional Printable Hydrogel Precursor Bioinks as Growth Factor Delivery Vehicles, S. Li*, S. Yerneni, A. Feinberg, P. Campbell; Carnegie Mellon University, Pittsburgh, PA, USA

1069. Intentional Positioning of Cells in a Decellularized Heart, B. Berron*(1), C. Li(1), M. Montalvo(1), A. Abdel-Latif(2); (1)University of Kentucky, Lexington, KY, USA, (2)UK HealthCare, Lexington, KY, USA

1070. Printing Colloidal Microgel Particles for Modular Tissue Engineering, D. Chester*(1,2), T. Ngobili(1), M. Daniele(1,2,3), A. Brown(1,2); (1)North Carolina State University and The University of North Carolina, Raleigh, NC, USA, (2)NC State University, Raleigh, NC, USA, (3)North Carolina State University, Raleigh, NC, USA

1071. Preparation of Electrospun Nanofibers with Desired Microstructures Using a Programmed 3D Nanofiber Collector, W. Ren*(1), L. Chen(1), A. AL-SHAWK(1), X. Wu(1), C. Rea(1), W. Chen(1), D. Markel(2); (1)Wayne State University, Detroit, MI, USA, (2)Providence Hospital, Southfield, MI, USA

1072. Programming via Printing: Printing of Ready-to-Trigger, Biocompatible, Shape-Memory Polymers, K. Pieri*, P. Chando, P. Soman, J. Henderson; Syracuse University, Syracuse, NY, USA

Biomaterials for Regenerative Engineering

1073. Cellular Response of MC3T3 E1 Cells on Nanofiber Shish Kebab Periodicity and Size, T. Yu*, M. Marcolongo, C. Li; Drexel University, Philadelphia, PA, USA

1074. Co-Culture of Osteoblasts and Endothelial Cells in a Chitosan/ GDP Scaffold to Improve Angiogenesis and Osteogenesis for the Treatment of Critical Size Bone Defects, C. Agnes*, T. Baudequin, M. Tabrizian; McGill University, Montreal, QC, Canada

1075. Compaction and Crosslinking of Nucleus Pulposus Replacement Improves Repair Efficacy in Spinal Kinematic Model, A. Garon*, R. Borem, J. Walters, J. Mercuri; Clemson University, Clemson, SC, USA

1076. Impact of Fibrin Microparticle Crosslinking Density on Physical and Rheological Properties of Composite Polyethylene Glycol-Fibrin Microparticle Hydrogels for use in Tendon Repair, K. Caspers*, K. Meyers, M. Kwesiga, B. Lee, R. Rajachar; Michigan Technological Institution, Houghton, MI, USA

1077. PLLA-PEG-PLLA Triblock Copolymers as Biodegradable Thermoplastic Elastomers for Nerve Guidance Channels, Y. Hu*, W. Wu, A. Ekenseair; Northeastern University, Boston, MA, USA

1078. Integrating Experiments and MD Simulations to Determine Hydrolytic Degradation of Aliphatic Polyesters for Surgical Suture Applications, R. Vaid*(1), M. King(1,2), M. Pasquinelli(1); (1)NC State University, Raleigh, NC, USA, (2)Donghua University, Shanghai, China

1079. Nanofiber-Hydrogel Composite Microparticles as a Stem Cell Delivery and Pro-Regenerative Material for Soft Tissue Defects, C. Chang*, C. Zhang, J. Chua; Johns Hopkins University, Baltimore, MD, USA

1080. Characterization of Detachable Gelatin/Chitosan Hydrogel for Tissue Engineering Applications, K. Kret*, A. Campbell Ritchie, C. Scotchford; The University of Nottingham, Nottingham, United Kingdom

1081. Physical and Chemical Characterization of Synthetic Bone Mineral Ink for Robocasting Applications, L. Witek*(2), D. Eckstein(1), C. Rivera(2), D. Mijares(2), P. Coelho(2,3); (1)Tandon School of Engineering, New York University, Brooklyn, NY, USA, (2)New York University, New York, NY, USA, (3)New York University Langone Medical Center, New York, NY, USA

1082. Nanofibers with Controlled Deformation, Y.H. Jeong*; Kyungpook National University, Daegu, Republic of Korea

1083. Silk Biomaterials with Multiple Cues for Vascularization Capacity, Q. Lu*, Z. Ding; National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, China

1084. Comparative in vitro Study of 3D Robocasting Scaffolds Using Beta Tricalcium Phosphate and Synthetic Bone Mineral, C. Rivera*(1), L. Witek(1), D. Mijares(1), A. Larranaga-Vega(2), B. Cronstein(2), P. Coelho(1,3); (1)New York University, New York, NY, USA, (2)New York University Langone Medical Center, New York, NY, USA, (3)New York University Langone, New York, NY, US

1085. Oriented Immobilization of Basic Fibroblast Growth Factor: a Novel Bioengineered Surface Design for the Expansion of Mesenchymal Stem Cells, A. SHAKYA*, E. IMADO, N.K. PHUONG, T. MATSUYAMA, K. HORIMOTO, I. HIRATA, K. KATO; Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan, Hiroshima, Japan

1086. Mis-concepts about Collagen in Regenerative Biomaterial Matrices, S. Gunasekaran*(1), C. Cox(2); (1)ENCOLL Corp., Fremont, CA, USA, (2)Kadiri Health LLC, Dayton, OH, USA

1087. Collagen Type I and II Blend Hydrogels with Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair, J. Liu*(1), C. Kilmer(1), A. Durkes(1), G. Breur(1), A. Panitch(2); (1)Purdue University, West Lafayette, IN, USA, (2)University of California, Davis, Davis, CA, USA

1088. A Hybrid Dendrimer Hydrogel as Bone Tuberculosis Defect Scaffold for Regeneration and Chemotherapy, J. Wang*(1), R. Cooper(2), B. Li(1), H. Yang(1,3,4); (1)Virginia Commonwealth University, School of Engineering, Richmond, VA, USA, (2)Virginia Commonwealth University, Richmond, VA, USA, (3)Virginia Commonwealth University, School of Pharmacy, Richmond, VA, USA, (4)Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA

1089. Nanofiber Microspheres for Cell Delivery, J. Xie*, J. John, S. Boda; University of Nebraska Medical Center, Omaha, NE, USA

1090. Defect Driven Gelation of 2D Nano-assemblies and Polymeric Binder for Bone Tissue Engineering, K. Deo*, M. Jaisawal, S. Bhunia, A. Gaharwar; Texas A&M University, College Station, TX, USA

1091. Cryogenic Formation of Multi-Layered Hydrogel Scaffolds with Tunable Interfaces, A. Najarzadeh*, E. Pyles, D. Puleo; University of Kentucky, lexington, KY, USA

1092. 2D Nanomaterials Functionalized 3D Nanofibrous Scaffolds for Bone Regeneration, H. Sun*(1), Q. Yao(2); (1)University of Iowa, Iowa City, IA, USA, (2)Wenzhou Medical University, Wenzhou, China

1093. β-Tricalcium Phosphate (β-TCP) Scaffold Promote Cell Infiltration in vitro, X. Wang*, M. Lin, Y. Kang; Florida Atlantic University, Boca Raton, FL, USA

1094. Performance of an Octacalcium Phosphate Biomaterial in a Long Bone Defect in Ovariectomized Rat, O. Suzuki*(1), K. Baba(1,2), Y. Shiwaku(1), T. Anada(1,3), Y. Mori(2), K. Tsuchiya(1), E. Itoi(2); (1)Tohoku University Graduate School of Dentistry, Sendai, Japan, (2)Tohoku University Graduate School of Medicine, Sendai, Japan, (3)Institute for Materials Chemistry and Engineering, Fukuoka, Japan

1095. Wound Healing Evaluation of Equine Amniotic Membrane Compared to Commercially Available Porcine Xenografts, R. Early*(1), H. Hewitt(1), H. Aberman(2); (1)SEED Biotech, Inc, Dallas, TX, USA, (2)Purdue University, Malvern, PA, USA

1096. Synthesis and Characterization of an Elastic and Biodegradable Poly(Xylitol-Dodecanedioic Acid) for Biomedical Engineering Applications, N. Firoozi*(1), Y. Kang(1,2); (1)Florida Atlantic University, Boca Raton, FL, USA, (2)FAU, Boca Raton, FL, USA

1097. In Vitro Model of Schwann Cell Migration in Multilayered Clickable Microsphere-Based Scaffolds with Tunable Degradation Rates, H. Meng*, D. Elbert; University of Texas at Austin, Austin, TX, USA

1098. Immunodeficiency Potentiates the Ability of Decellularized Muscle Matrix to Regenerate a Volumetric Muscle Injury, L. Olson*(1), D. Cohen(1), B. Boyan(1,2), Z. Schwartz(1,3), M. McClure(1); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA, (3)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA

1099. Decellularized Materials Derived from Genetically Engineered Mice with Enhanced Regenerative Potential, T. Kyriakides*, A. Morris; Yale University, New Haven, CT, USA

1100. Identifying the Cell-Cell Communication Network Driving Methacrylic Acid (MAA)-Based Biomaterial Nerve Growth, A. Androschuk*, I. Talior-Volodarsky, R. Mahou, M. Sefton; University of Toronto, Toronto, ON, Canada

1101. Biomimetic Modification of Thermoresponsive Hydrogel Scaffolds for Enhanced Mucoadhesion, N. Kanetkar*, A. Ekenseair; Northeastern University, Boston, MA, USA

1102. Oxygen-generating Polycaprolactone/Calcium Peroxide Microparticles to Support Cell Survival in Hypoxic Environment, T. Kiratiwongwan*, M. Zhang, W. Shen; University of Minnesota, Minneapolis, MN, USA

1103. Development and Optimization of Modular Self-Assembling Nucleopeptide-Based Scaffolds for Tissue Engineering Applications, A. Noblett*, K. Baek, L. Suggs; The University of Texas at Austin, Austin, TX, USA

1104. In vitro and in vivo Evaluation of Commercially Available Acellular Human Amniotic Membrane and Porcine Xenografts, R. Early*(1), H. Hewitt(1), H. Aberman(2); (1)SEED Biotech Inc., Dallas, TX, USA, (2)Purdue University, Malvern, PA, USA

1105. Gene Silencing Therapy for In Situ Elastic Matrix Regenerative Repair, S. Carney*(1,2), T. Broekelmann(3), R. Mecham(3), A. Ramamurthi(1,2,4); (1)Cleveland Clinic, Cleveland, OH, USA, (2)Case Western Reserve University, Cleveland, OH, USA, (3)Washington University at St. Louis, St. Louis, MO, USA, (4)Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

1106. Adipose Derived Mesenchymal Stem Cells Seeded on Biomimetic Polymer Scaffolds Induce Rapid Bone Regeneration Across a Large Segmental Bone Defect, D. Margolis*, D. Gonzales, J. Smith, J. Szivek; The University of Arizona, Tucson, AZ, USA

1107. Proteoglycan/gelatin Hydrogel via Enzymatic Gelation for Tissue Engineering Applications, W.-B. Tsai*(1), S.C. Ng(1), E. Bernotiene(2), A. Sobolev(3); (1)National Taiwan University, Taipei, Taiwan, (2)State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania, (3)Latvian Institute of Organic Synthesis, Riga, Latvia

1108. The differentiation potential of human mesenchymal stem cell in three-dimensional cues-integrated-biomaterials, M.H. Park*; Korea Institute of Ceramic Engineering & Technology (KICET), Cheongju-si, Republic of Korea

1109. Design of tissue-specific extracellular matrix composite hydrogels for adipose-derived stem/stromal cell delivery, A. Shridhar*(1), B. Amsden(2), E. Gillies(1), L. Flynn(1); (1)University of Western Ontario, London, ON, Canada, (2)Queens University, Kingston, ON, Canada

1110. A Gradient Hierarchical Scaffold Induces in vivo Regeneration of Two Kinds of Tissues, S. Zhang*, Y. Du, J. Wang; Huazhong University of Science and Technology, Wuhan, China

1111. Novel hybrid hydrogels with tunable properties by incorporating polyethylene glycol (PEG)-based hydrogels for tissue engineering, J. Kim*, B. Kim; Hongik University, Sejong, Republic of Korea

1112. 3D Reconstruction through Two-Layered Tubular Scaffold and Bioreactor Cultivation in Circumferential Esophageal Defect., I.G. Kim*(1), Y. Wu(2), H. Cho(1), J.-W. Shin(2), E.-J. Chung(1); (1)Seoul National University Hospital, Seoul, Republic of Korea, (2)Inje University, Gimhae, Republic of Korea

1113. Transfection of dexamethasone-conjugated PEI nanoparticles complexed with pDNA and shRNA controls multilineage differentiation of hMSCs, H.J. Kim*, J.S. Park, K.H. Park, J.M. Park; CHA university, Seongnam-si, Republic of Korea

1114. Development of a Photocurable Shape Memory Polymer via Acrylation of Poly(glycerol dodecanoate), R. Akman*(1,2), H. Ramaraju(1,2), S. Hollister(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)GIT, Atlanta, GA, USA

1115. Predicting Vascularization in Porous Hydroxyapatite Scaffolds using a Computational Model, E. Jui*, S. Montelongo, T. Guda; University of Texas at San Antonio, San Antonio, TX, USA

1116. Crosslinked Hyaluronan Hydrogels in Hyaluronan-Chitosan Capsules Synergize with Collagen I to Retain Secreted ECM and Promote MSC Chondrogenesis, T. Alamin*, C. Gabrion, H. Matthew; Wayne State University, detroit, MI, USA

Bioprintable Hydrogels for 3D Tissue Fabrication

1117. Mask Projection Microstereolithography (3D Printing) of Gelatin Methacrylate, W. Surbey*(1), N. Chartrain(1), A. Whittington(1,2); (1)Virginia Tech, Blacksburg, VA, USA, (2)Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

1118. Shear-thinning, Thermally Responsive Poly(N-isopropylacrylamide)-based Bioink for 3D Bioprinting Applications, Y.S. Kim*, A. Navara, A. Chien, A. Mikos; Rice University, Houston, TX, USA

1119. Novel Enzymatically Cross-linked Silk Fibroin Bioink for Bioprinting of Patient-Specific Memory-Shape Implants for Meniscus Regeneration, J. Costa*(1,2,3), J. Silva-Correia(1,2), R. Reis(1,2,3), J. Oliveira(1,2,3); (1)3Bs Research group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco/Guimaraes, Portugal, (2)ICVS/3B’s–PT Government Associate Laboratory, Braga, Portugal, (3)cThe Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Barco/Guimarães, Portugal

1120. A Bioadhesive Hydrogel for Sealing and Treatment of Corneal Lacerations, E. Shirzaei Sani*(1), C. Jumelle(2), A. Kheirkhah(2), Y. Taketani(2), Z. Sun(2), R. Dana(2), N. Annabi(1); (1)University of California - Los Angeles, Los Angeles, CA, USA, (2)Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA

1121. 3D Printing Environmentally Responsive Medical Devices, D. Cohn*; Hebrew University of Jerusalem, Jerusalem, Israel

1122. Dual Crosslinking Strategy to Enhance the Mechanical Properties and Stability of Methacrylated Collagen Hydrogels, N. Kajave*, T.-U. Nguyen, V. Kishore; Florida Institute of Technology, Melbourne, FL, USA

1123. Development of Self-Assembling Peptide inspired Bioinks for Neural Tissue Engineering Applications, M. Boyd-Moss*(1,2), A. Quigley(2,3,4), K. Firipis(1,2), B. Long(5), D. Nisbet(6), R. Williams(1,2); (1)RMIT, Bundoora, Australia, (2)St Vincents Hospital, Fitzroy, Australia, (3)University of Wollongong, Wollongong, Australia, (4)University of Melbourne, Parkville, Australia, (5)Federation University, Mount Helen, Australia, (6)Australian National University, Canberra, Australia

1124. 3D Printing of Decellularised Porcine Lung ECM, S. Tas*, D.A. Bölükbas, H. Alsafadi, D.E. Wagner; Lund University, Lund, Sweden

1125. Polymers for Additive Manufacturing, E. Alam*, B. Treiber, G. Brokaw, B. Sewell, I. Lipe, B. Scammon, V. Reukov; Clemson University, Clemson, SC, USA

1126. Effect of a Cryogenic Build Platform on 3D Printed Hydrogel, L. Warburton, C. Liu, P. Vemulakonda, N. Kewalramani, Y. Cheema, D. Sidelnikov, K. Dharmadhikari, M. Hildreth, A. Rodriguez, K. Aroom, L. Schultheis*; Gemstone Honors Program, College Park, MD, USA

1127. The tailored 3D-bioprinted gelatin scaffold fabricated by physical cross-linked without chemical cross-linking agents, C.-H. Kim*, D.J. Choi, S.J. Park; Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea

Tissue Engineering SIG

1128. Pre-differentiated Human Bone Marrow Stromal Cells and Platelet-rich Plasma Pretreated PLGA Scaffold for Meniscal Regeneration, J.J. Yoo*, H.J. Kim; Seoul National University College of Medicine, Seoul, Republic of Korea

1129. Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells Induced by 2D Nanosilicates, A. Gaharwar*(1), J. Carrow(1), L. Cross(1), R. Reese(1), M. Jaiswal(1), C. Gregory(2), R. Kaunas(1), I. Singh(3); (1)Texas A&M University, College Station, TX, USA, (2)Texas A&M Health Science Center, College Station, TX, USA, (3)Memorial Sloan Kettering Cancer Center, New York, NY, USA

1130. Recombinant Human Bone Morphogenetic Protein 2 Delivery from Tunable Keratin Biomaterials in a Critically-Sized Rat Femur Defect Model, J. Saul*(1), J. Bohnert(1), M. O'Brien(1), T. Carnwath(1), S. Alnuaimi(1), T. Smith(2); (1)Miami University, Oxford, OH, USA, (2)Wake Forest University School of Medicine, Winston-Salem, NC, USA

1131. Developing A 3D Niche Microenvironment To Improve Stem Cell-Derived β-Cell Maturation For Treatment of Type 1 Diabetes, R. Youngblood*(1), D. Clough(1), C. Cras-Meneur(2), L. Shea(1); (1)University of Michigan, Ann Arbor, MI, USA, (2)University of Michigan, Ann Arbor, Ann Arbor, MI, USA

1132. Development of Spiral Scaffolds with 3D Printing-based Combinatorial Technologies for Bone Tissue Engineering, A. Kumar*, X. Yu; Stevens Institute of Technology, Hoboken, NJ, USA

1133. X-ray Phase Contrast Imaging of Soft Biomaterials in a Whole-Animal Model, J. Brown*(1), S. Somo(2), F. Brooks(3), S. Komarov(3), W. Zhou(3), M. Anastasio(3), E. Brey(1); (1)The University of Texas at San Antonio, San Antonio, TX, USA, (2)Illinois Institute of Technology, Chicago, IL, USA, (3)Washington University in St. Louis, St. Louis, MO, USA

1134. Vitamin C and B3 as New Biomaterials to Alter Intestinal Stem Cells, Y. Qi*, J. Lohman, N. Peroutka-Bigus, B. Bellaire, M. Wannemuehler, Q. Wang; Iowa State University, Ames, IA, USA

1135. Evaluation of Schwann Cells Proliferation on Heparin-collagen Layer-by-Layer Coatings, L.C. Pinzon Herrera*, J. Almodovar Montanez; University of Arkansas, Fayetteville, AR, USA

1136. Osteoinductive PolyHIPE Scaffolds as Improved Bone Void Fillers, P. Dhavalikar*(1), K. Salhadar(1), T. Wilems(1), D. Stahl, B. Saunder, E. Cosgriff-Hernandez(1); (1)UT Austin, Austin, TX, USA

1137. Engineering Vascularized Adipose Tissue Using Microvascular Fragments in Fibrin Hydrogels, F. Acosta*, K. Stojkova, E. Brey, C. Rathbone; The University of Texas at San Antonio, San Antonio, TX, USA