Biomaterial-Tissue Interaction SIG

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm
Room: Virtual

About

Events that follow binding of the first host ion to an implant’s surface are dictated by reactions not well understood for any biomaterial or device. Understanding these events is the purpose of the Biomaterial-Tissue Interaction Special Interest Group. Only through such understanding can one definitively answer such questions as: “Why did it fail?” and “What led to its success that we can apply to future devices?” These answers will come from such fields as physiology, immunology, pathology, biomechanics and material science. They will apply to the subjects of every other SIG in the Society. All those interested in the mechanisms of host-implant interaction are welcome to join BTI's quest.

Moderator:
Floyd Karp, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 83. Artificial meninges reduce fibroblastic and astroglial responses in a rabbit cord transection, Barbie Varghese1, Duke Shereen2, Alan Seifert3, Lauren Bright1, Antonio Merolli11Rutgers University, Piscataway, NJ, USA, 2City University of New York, New York, NY, USA, 3Icahn School of Medicine Mount Sinai, New York, NY, USA

  • 84. ECM Components Recruited with Peritoneal Preimplantation and Correlation with Vascular Graft Outcomes, Valentina Ochoa Mendoza, Mahyar Sameti, PhD, Lisa Moore, PhD, Chris A Bashur, PhDFlorida Institute of Technology, Melbourne, FL, USA

  • 85. Toll-like receptor mediated macrophage responses to adsorbed cellular damage molecules, Laura McKiel, PhD, Kimberly Woodhouse, PhD, Lindsay Fitzpatrick, PhDQueen's University, Kingston, ON, Canada

  • 86. Generation of Mesenchymal Meta-Tissues Using Multi-Photon Lithography, Chenyan Wang1, Zacharias Vangelatos2, Tackla Winston1, Costas Grigoropoulos, PhD2, Zhen Ma, PhD11Syracuse University, Syracuse, NY, USA, 2University of California, Berkeley, Berkeley, CA, USA

  • 87. Tunable CaproGlu adhesives for enhanced tissue compatibility, Ivan Solic, Ivan Djordjevic, Manisha Singh, Terry SteeleNanyang Technological University, Singapore, Singapore

  • 88. Glycosaminoglycans and Dexamethasone Influence Trabecular Meshwork Cell Behavior on 3D Scaffolds, Bikram Adhikari1, Melissa Krebs1, Mina Pantcheva, MD21Colorado School of Mines, Golden, CO, USA, 2University of Colorado School of Medicine, Aurora, CO, USA

Biomaterials-based Strategies for Endogenous Tissue Regeneration – 1

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm
Track: Tissue Engineering and Regenerative Medicine

About

Large tissue defects are still challenging to be effectively repaired by using current methods. Instead of relying on a large number of exogenous cells and/or proteins-based tissue engineering approaches, the strategies that using biomaterials to promote tissue regeneration by activating and harnessing endogenous reparative cells and signaling pathways are more promising and translational. Interesting endogenous signaling pathways that contribute to tissue regeneration include but not limited to angiogenesis, inflammation, stem cell recruitment, and differentiation, etc. This session will focus on introducing the emerging concepts and strategies in the development of innovative biomaterials/drug/gene delivery/stem cell techniques for challenged tissue regeneration, e.g., cartilage, bone, teeth, skin, muscle, etc. Long term goal for this session is to develop new biomaterials-based regenerative treatments by using the body's
innate ability through promoting the collaborations from the multidisciplinary filed.

Moderators:
Hongli Sun, PhD
Bin Duan, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 77. Sulfated Hydrogels to Prolong Localized Availability of the Stromal Cell
    Secretome, Marissa Gionet-Gonzales1, Daphne Diloretto1, Clara Ginnell1, J.
    Kent Leach1,2, 1University of California Davis, Davis, CA, USA, 2UC Davis
    Health, Sacramento, CA, USA

  • 78. Modifying Mineralized Collagen Scaffolds to Modulate the Inflammatory
    Response in Craniomaxillofacial Defects and Enhance Bone Regeneration,
    Vasiliki Kolliopoulos, Marley Dewey, Brendan Harley, PhD, Mai Ngo,
    University of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 79. Single-step peptide functionalization for spatially organized 3D-printed
    scaffolds, Paula Camacho, Kelly Seims, Hafiz Busari, Hannah Dailey, Lesley
    Chow

  • 80. Characterization of Highly Elastic, Biodegradable Citrate-based Elastomer for
    Tissue Engineering, Thao Nguyen, Madeleine Goedegebuure, Arun Sharma,
    PhD, Guillermo Ameer, PhD, Northwestern University, Evanston, IL, USA

Invited Speaker(s)

Dental/Craniofacial Biomaterials

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Virtual

About

The Dental/Craniofacial Biomaterials Special Interest Group focuses on basic, applied, and clinical biomaterials research using approaches ranging from synthetic materials to biological mechanisms of therapy, and including materials/biological constructs and tissue structure-function analyses as biomimetic/design bases. Each of these approaches converge into the larger objective of restoring oral tissue structure and function. Issues related to materials used or having potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region are included. New dental biomaterials technologies include advanced inorganic and organic materials, biomimetics, smart materials, tissue engineering, drug delivery strategies and surface modified materials.

Moderator:
Santiago Orrego, PhD
Xiaohua Liu, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 89. Polymeric Coatings for Percutaneous Devices Direct Pericellular Laminin for Hemidesmosome Formation, Nicholas Fischer, David De Jong, Conrado AparicioUniversity of Minnesota, Minneapolis, MN, USA

  • 90. A new approach to evaluate the bond strength of dental restorations, Carolina Montoya, PhD, Anubhav Jain, DDS, Santiago Orrego, PhDTemple University, Philadelphia, PA, USA

  • 91. Do Quaternary Ammonium Based-Dental Composites Affect the Subgingival Microbiota? A Study on Microcosm Biofilms Cultured from Subgingival Plaque, Abdulrahman Balhaddad1,2, Isadora Garcia3, Lamia Mokeem1, Maria Ibrahim1,2, Fabrício Collares3, Michael Weir1, Huakun Xu1, Mary Anne Melo11University of Maryland, Baltimore, Baltimore, MD, USA, 2Imam Abdulrahman Bin Faisal University, Baltimore, Saudi Arabia, 3Federal University of Rio Grande do Sul, Porto Alegre, Brazil

  • 92. Translation of 3D-Painted Hyperelastic Bone® Advanced Biomaterial Products for Off-the-Shelf and Patient-Matched Dental and Maxillofacial Repair and Regeneration, Adam Jakus, PhDDimension Inx, Chicago, IL, USA

  • 93. Siloxane-Containing Shape Memory Polymer (SMP) Scaffolds for Cranial Bone Defect Repair, Felipe Beltran, Christopher Houk, Melissa Grunlan, PhDTexas A&M University, College Station, TX, USA

  • 94. Surpassing Short-term Antibacterial Activity for Bioactive Dental Composites with Quaternary Ammonium compound: A Long-term Evaluation after Artificial Aging, Abdulrahman Balhaddad1,2, Lamia Mokeem1, Michael Weir1, Huakun Xu1, Mary Anne Melo11University of Maryland, Baltimore, Baltimore, MD, USA, 2Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

Immune Engineering SIG

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm
Track: Immunomodulatory Biomaterials
Room: Virtual

About

Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy (immune-modulation), cell and gene therapy, immune microenvironment engineering, and systems immunology. These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.

Moderators:
Kara Spiller, PhD,
Lance Kam, PhD,
Rebecca Pompano, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 95. An Antigen-Specific Microparticle System Shows Efficacy in a Mouse Model of Multiple Sclerosis, Alexander Kwiatkowski1, Joshua Stewart, PhD1, Eric Helm2, Theodore Drashansky, PhD2, Dorina Avram, PhD2,3, Benjamin Keselowsky, PhD11University of Florida, Gainesville, FL, USA, 2University of Florida, Gainesville, FL, USA, 3H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

  • 96. Lipid Nanoparticle-Mediated mRNA Delivery for CAR T Cell Engineering, Margaret Billingsley, Michael Mitchell, PhDUniversity of Pennsylvania, Philadelphia, PA, USA

  • 99. Exogenous Delivery of Indoleamine 2,3-Dioxygenase Reverses Disease Severity in Psoriasis, Sabrina Macias, Marija Zovko, Isha Verma, Arun Wanchoo, PhD, Gregory Hudalla, PhD, Benjamin Keselowsky, PhDUniversity of Florida, Gainesville, FL, USA

  • 100. Quality of CD8+ T cell Immunity Evoked in Lymph Nodes is Compartmentalized by Route of Antigen Transport and Functional in Tumor Context, Meghan O'Melia1,2, Nathan Rohner1, Margaret Manspeaker1, David Francis1, Haydn Kissick2, Susan Thomas1,21Georgia Institute of Technology, Atlanta, GA, USA, 2Emory University, Atlanta, GA, USA

  • 101. PEGylation of Indoleamine 2,3-Dioxygenase for Addressing Systemic Immune Regulation, Jennifer Simonovich1, Arun Wanchoo1, Alexander Kwiatkowski1, Dorina Avram2, Gregory Hudalla1, Benjamin Keselowsky11University of Florida, Gainesville, FL, USA, 2H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

  • 102. Liver targeting synthetic glycosylations: Engineering humoral tolerance to protein therapeutics, Scott Wilson, PhD1, Kym Brunggell, PhD2, Michal Raczy2, Rachel Wallace2, Andrew Tremain2, Jeffrey Hubbell, PhD21Johns Hopkins University, Baltimore, MD, USA, 2University of Chicago, Chicago, IL, USA

Nanomaterials SIG

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm
Track: Therapeutic Delivery
Room: Virtual

About

The mission of the Nanomaterials SIG is to advocate for and organize the exchange of ideas involving the unique science and technology present in biomaterials at the nanoscale. By focusing on science, the SIG will champion the continual push to uncover new knowledge at the nanoscale and connect this to macroscale properties and behaviors of biomaterials. Through its focus on technology, the SIG will foster innovative design and synthesis of nanobiomaterials useful in the creation of new and better devices, diagnostics and therapeutics for biomedical applications. The SIG emphasizes an interdisciplinary vision to facilitate the translation of nanomaterials to achieve intended biological significance and medical impact. The vision is to establish the NanoSIG to become a thought leader in the nanobiomaterials research community by emphasizing nanoscience discovery, nanotechnology application, and clinical translation innovation.

Moderator:
Ming Su, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 103. Sustained & Localized Cyclosporine Delivery and Activity Using Nanomicelles and Nanofibrils, Diana Velluto, PhD, Damir Bojadzic, Teresa De Toni, Peter Buchwald, PhD, Alice Tomei, PhDUniversity of Miami, Miami, FL, USA

  • 104. Application of Magnetic Particle Imaging Technology to Understand Nanoparticle Biodistribution in Osteoarthritic Joints, Tolulope AjayiUniversity of Florida, Gainesville, FL, USA

  • 105. Dual-Nanoparticle System for Enhanced Drug Accumulation and Prolonged Retention in Metastatic Cancers, Michaela Prado1,2,3, Pere Dosta, PhD1,2, Pau Hurtado, MSc1,2, Natalie Artzi, PhD1,21Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA, 2Massachusetts Institute of Technology, Cambridge, MA, USA, 3Tecnológico de Monterrey, Monterrey, Mexico

  • 107. Protein corona formed on nanoparticles is sensitive to isomeric differences in surface chemistry, Sridevi Baradhwaj Conjeevaram, Ryan BlanchardTexas A&M University, College Station, TX, USA

  • 108. Targeting Scavenger Receptor Type B1 and Cellular Cholesterol with High-Density Lipoprotein Mimetic Nanoparticles Inhibits SARS-CoV-2 Infection, Stephen Henrich, Kaylin McMahon, PhD, Nicole Palacio, Pablo Penaloza-McMaster, PhD, Colby Thaxton, MD, PhDNorthwestern University, Chicago, IL, USA

Postdoctoral Recognition Award (PRA) competition

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Moderators:
    Maria Coronel, PhD
    Claudia Loebel, MD, PhD
    Tatiana Segura, PhD
    Kristi Anseth, PhD
    Andres J. Garcia, PhD
    David H. Kohn, PhD
    Cherie Stabler, PhD

STAR Awards - Session 2

Timeslot: Wednesday, April 21, 2021 - 3:15pm to 4:45pm

About

Dental/Craniofacial Biomaterials

91. "Do Quaternary Ammonium Based-Dental Composites Affect the Subgingival Microbiota? A Study on Microcosm Biofilms Cultured from Subgingival Plaque," Abdulrahman Balhaddad

Immune Engineering

99. "Exogenous Delivery of Indoleamine 2,3-Dioxygenase Reverses Disease Severity in Psoriasis," Sabrina Macias

100. "Quality of CD8+ T cell Immunity Evoked in Lymph Nodes is Compartmentalized by Route of Antigen Transport and Functional in Tumor Context," Meghan J. O’Melia

Nanomaterials

36. "Stimuli-Responsive Nanoreporter for Early Monitoring of Immunotherapy Response," Anh Nguyen

107. "Protein Corona Formed on Nanoparticles Is Sensitive to Isomeric Differences In Surface Chemistry," Sridevi Conjeevaram

Ophthalmic Biomaterials

545. "Mucoadhesion and Mucopenetration of Self-assembled Poly(Lactic Acid)-Block-Poly(Oligoethylene Glycol Methacrylate) Block Copolymer Nanoparticles with Different Ethylene Oxide Side-Chain Lengths," Ridhdhi Dave

Orthopaedic Biomaterials

159. "Biomimetic Mg-Doped Type I Collagen / Hydroxyapatite Scaffold and Membrane Induces Osteogenesis in Mesenchymal Stem Cells Faster than in 2D Environment," Ava Brozovich

76. "Using Chemical Imaging in Probing Spectral Biomarker of Pseudo-capsule Macrophages in Response to Metal Debris," Songyun Liu

Surface Characterization & Modification

271. "Effects of Zwitterionic Polymer Brush Density and Chain Length on Resisting Protein Adsorption," Julia King

130. "Tannin/glycosaminoglycan-based Polyelectrolyte Multilayers Improve the Endothelialization of TiO2 Nanotubes," Roberta Sabino

Tissue Engineering

58. "Bio-Mimetic Peptide Nanofiber Hydrogel Promotes Regenerative Healing in the Murine and Porcine In Vivo Models," Maksym Krutko

43. "Engineered Human Tissues for Assessing Cosmic Radiation Damage," Daniel Tavakol

109. "A Gelatin Hydrogel Model of the Endometrium and Trophoblast Invasion," Samantha Zambuto

Abstracts

Abstracts will be available for download on April 20, 2021.