Con-current Oral Abstract Presentations Session I

Surface Modification and Characterization of Biomaterials (General Session)


Solution Piezoresponse Force Microscopy of Lysozyme and Insulin Amyloid Fibrils

G. L. Thompson, III1, B. J. Rodriguez2, S. V. Kalinin2, A. A. Vertegel1;
1Clemson University, Clemson, SC, 2Oak Ridge National Laboratory, Oak Ridge, TN.


The Structure and Hybridization Properties of DNA Monolayers Engineered for Complex Media Applications

L. J. Gamble1, C-Y. Lee1, P-C. Nguyen1, D. W. Grainger2, D. G. Castner1;
1University of Washington, Seattle, WA, 2University of Utah, Salt Lake City, UT.


Surface Characterization and Investigation of Protein Adsorption for the Optimization of Microcapsule Biopeformance

S. K. Tam1, L. Yahia1, J-P. Hallé2, B. J. de Haan3, S. Polizu1, P. de Vos3;
1École Polytechnique de Montréal, Montréal, PQ, CANADA, 2Guy-Bernier Research Center, Montréal, PQ, CANADA, 3University Medical Center Groningen, Groningen, THE NETHERLANDS.


Immobilization of Therapeutics on Metal Surfaces Using Self Assembled Monolayers

G. Mani1, D. M. Johnson1, D. Marton2, V. Dougherty1, M. Feldman2, D. Patel2, A. Ayon1, C. M. Agrawal1;
1The University of Texas at San Antonio, San Antonio, TX, 2The University of Texas Health Science Center at San Antonio, San Antonio, TX.


Thermoplastic Polycarbonate-urethane with Covalently-Bonded C-18 End Groups: Surface and Bulk Properties

R. Ward, K. McCrea, Y. Tian, J. Yang, S. Wang, J. Parakka, N. Harjati, R. Ward;
Polymer Technology Group, Berkeley, CA.


Polypeptide Multilayer Films as Artificial Extracellular Matrices

D. T. Haynie, S. M. Sriram, N. Palath, L. Zhang, J. S. Rudra, K. Dave;
Artificial Cell Technologies, New Haven, CT.


Molecular Detection of Fibrinogen on Poly (dimethyl siloxane) by Atomic Force Microscopy

P. Soman1, C. Siedlecki2;
1Penn State University, Hershey, PA, 2Pennsylvania State University, Hershey, PA.


Enhanced Cellular Behaviour on Plasma-modified Electrospun Biodegradable Nanofiber Meshes

A. Martins1, E. D. Pinho1, J. Cunha2, F. Macedo2, R. L. Reis1, N. M. Neves1;
1University of Minho - 3B's Research Group, Braga, PORTUGAL, 2University of Minho - Department of Physics, Braga, PORTUGAL.

Advances in Drug Delivery I(General Session)


A Novel Family of Polymeric Carriers for Intracellular Drug Delivery

P. S. Stayton, A. S. Hoffman;
University of Washington, Seattle, WA.


Worm-like and spherical micelles made from the same PEO-PCL: advantages of paclitaxel delivery using worm-like micelles

S. Cai1, T. Minko2, D. E. Discher1;
1University of Pennsylvania, Philadelphia, PA, 2State University of New Jersey - Rutgers, Piscataway, NJ.


Controlled Release of Antibiotics and Bactericidal Effect of Thin Sol-Gel Film on Metallic Implant Device

S. Radin1, V. Antoci, Jr.2, N. J. Hickock2, C. S. Adams2, J. Parvizi2, I. Shapiro2, P. Ducheyne1;
1University of Pennsylvania, Philadelphia, PA, 2Thomas Jefferson University, Philadelphia, PA.


Engineering of targeted protein therapeutics: Recombinant N-TIMP-3 with a targeting domain for articular cartilage

D. A. Rothenfluh, M. Martino, J. A. Hubbell;
Ecole Polytechnique Lausanne, SWITZERLAND.

Outstanding Research by a Resident Award Recipient


Fabrication of biodegradable polyurethane/poly(lactide-co-glycolide) nanofibrous sheets with controlled antibiotic release via two stream electrospinning

Y. Hong, J. Guan, J. J. Stankus, W. R. Wagner;
1McGowan Institute for Regenerative Medicine, Pittsburgh, PA.


Therapeutic Contact Lenses: In-vitro Release via Experimental Physiological Ocular Tear Flow Model

M. Ali, J. Zhang, J. Saha, S. Pass, S. Horikawa, J. Hong, M. E. Byrne;
Auburn University, Auburn, AL.


Enzyme immobilization for the controlled release of a bioactive molecule from hydrogels

C. D. Donahoe, M. M. Kaneda, S. K. Alford, B. K. Wacker, D. L. Elbert;
Washington University, St. Louis, MO.


Nanocomposite Hydrogels as Remote Controlled Drug Delivery Systems

N. S. Satarkar, J. Hilt;
University of Kentucky, Lexington, KY.

Biomaterial-based Bridges for Neural Regeneration (Symposium)


The reality of stem cell grafting for CNS injury

S. R. Whittemore,
University of Louisville, Louisville, KY.


Methylcellulose-Laminin Hydrogel Supports Migration and Influences Differentiation of Neural Stem Cells

S. E. Stabenfeldt, A. J. García, M. C. LaPlaca;
Georgia Institute of Technology, Atlanta, GA.


A dopamine-based poly(aminoglycerol ester) induces significant neurite extension in differentiated PC12 cells and rat DRGs

J. Gao1, Y. Kim2, H. Coe1, B. Zern1, B. Sheppard3, Y. Wang1;
1Georgia Institute of Technology/Emory University, Atlanta, GA, 2Kyungpook National University, Daegu, REPUBLIC OF KOREA, 3University of Florida, Gainesville, FL.


Anisotropic Hydrogel Scaffolds Enhance Peripheral Nerve Regeneration Across Long Nerve Gaps

M. Dodla1, V. K. Haftel2, R. V. Bellamkonda1;
1Georgia Institute of Technology, Atlanta, GA, 2Morehouse College, Atlanta, GA.


Three Dimensional Aligned Individual Nano-fibers For Neural Tissue Engineering

V. Beachley, X. Wen;
Clemson University, Charleston, SC.


Effects of Bridging a Gap in the Rat Spinal Cord with a Collagen Tube and Membrane

S. Matin1, R. H. Cholas2, H-P. Hsu1, I. V. Yannas3, M. Spector1;
1VA Boston Healthcare System, Boston, MA, 2Massachusetts Institite of Technology, Cambridge, MA, 3Massachusetts Institute of Technology, Cambridge, MA.


Human Hair Derived Keratins Mediate Schwann Cell Behavior in vitro and Facilitate Rapid Peripheral Nerve Regeneration in vivo

P. Sierpinski, J. Garrett, J. Ma, P. Apel, T. Smith, A. Atala, L. A. Koman, M. Van Dyke;
Wake Forest University School of Medicine, Winston Salem, NC.

Polysaccharide-based Biomaterials I (General Session)


Crosslinked Carboxymethylcellulose Hydrogels: Versatile Platforms for Studying Cellular Behavior in 3D Biomaterials

L. Lombardo, R. Reeves, A. Ribeiro, J. B. Leach;
University of Maryland, Baltimore County, Baltimore, MD.


Hyaluronic Acid-Based Microgel Systems with Tunable Viscoelasticity and Therapeutic Potentials for Soft Tissue Regeneration

X. Jia, N. Sahiner, A. Jha;
University of Delaware, Newark, DE.


Chondroitin Sulfate based hydrogel niche for chondrogenic differentiation of mesenchymal stem cells

S. Varghese, N. Hwang, A. Canver, D. Lin, P. Theprungsirikul, J. Elisseeff;
Johns Hopkins University, Baltimore, MD.


Synthesis and Characterization of a Photocrosslinkable Collagen-Hyaluronan Interpenetrating Network for Neural Tissue Engineering : An ECM mimic

S. Suri, C. Schmidt;
University of Texas at Austin, Austin, TX.


Release Rate Controls Biological Activity of Nerve Growth Factor Delivered from Fibrin Matrices Containing Affinity-based Drug Delivery Systems

M. D. Wood, S. E. Sakiyama-Elbert;
Washington University, St. Louis, MO.


Controlled Release of PRP-Derived Growth Factors from Alginate Hydrogel Carriers Promotes Osteogenic Differentiation of Mesenchymal Stem Cells

S. S. Lin, R. Landesberg, S. B. Eisig, H. H. Lu;
Columbia University, New York, NY.


Exogenous Insulin-like Growth Factor-1 Delivery Effects on Endogenous Signaling of Encapsulated Chondrocytes in Alginate Hydrogels

D. M. Yoon, J. P. Fisher;
University of Maryland - College Park, College Park, MD.


Hyaluronic Acid Mediation of Mesenchymal Stem Cell Behavior in Photocrosslinkable Hydrogels

C. Chung, J. A. Burdick;
University of Pennsylvania, Philadelphia, PA.

Tissue Engineered Products for Clinical Applications I (General Session)


Mechano-Active Cartilage Tissue Engineering using 3-Dimensional and Dynamic Environments

S. Kim1, Y. Jung1, S. Kim1, S-H. Kim1, Y. Kim2, B. Min3;
1Korea Institute of Science and Technology, Seoul, REPUBLIC OF KOREA, 2Gwangju Institute of Science and Technology, Gwangju, REPUBLIC OF KOREA, 3Seoul National University, Seoul, REPUBLIC OF KOREA.


Nanobased Fiber Matrices for Wound Repair: Optimization for Human Skin Fibroblast Growth

S. G. Kumbar;
University of Virginia, Chalottesville, VA.


Novel Polymers and Nanocomposites as Injectable Bone Tissue Engineering Materials

S. Wang, D. H. Kempen, K-w. Lee, M. J. Yaszemski, L. Lu;
Mayo Clinic, Rochester, MN.


Healing Bone Using a Biomimetic Tubular Sintered Microsphere Matrix: In Vitro Polymer Evaluation and In Vivo Bone Regeneration

M. D. Kofron1, A. Griswold1, K. Martin2, S. G. Kumbar1, X. Wen3, C. T. Laurencin1;
1University of Virginia, Charlottesville, VA, 2Medical University of South Carolina, Charleston, SC, 3Clemson University, Clemson, SC.


Human Stem Cell Growth within Superporous Poly(ethylene glycol)-based Hydrogels

R. A. Gemeinhart;
University of Illinois at Chicago, Chicago, IL.


Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts the use of xneogeneic products

D. Murakami1, M. Yamato2, T. Ohki2, R. Takagi2, H. Namiki1, T. Okano2;
1Waseda University, Tokyo, JAPAN, 2Tokyo Women's Medical University, Tokyo, JAPAN.


Extracellular Matrix Derived Gel for Cardiac Tissue Engineering Applications

D. O. Freytes1, K. Tobita2, J. P. Tinney2, B. B. Keller2, J. W. Wainwright1, J. Martin2, S. S. Velankar2, S. F. Badylak1;
1McGowan Institute for Regenerative Medicine, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA.


Chemoattractant Degradation Products of Extracellular Matrix Bioscaffolds

E. P. Brennan, J. Reing, L. Zhang, J. M. Myers-Irvin, S. F. Badylak;
University of Pittsburgh, Pittsburgh, PA.

Orthopedic SIG: Total Joint (General Session)


Effect of Anatomic and Inverted Test Position on the Wear of Crosslinked UHMWPE Liners in a Hip Simulation Study

M. Aehle1, A. Alberts2, Y-S. Liao2;
1Case Western Reserve University, Cleveland, OH, 2DePuy Orthopaedics, Inc., Warsaw, IN.


Surface Evaluation and Wear of Explanted Conventional and Highly Cross-linked Polyethylene Acetabular Liners

M. P. Laurent1, M. J. Salineros2, J. J. Jacobs1, M. A. Wimmer1, R. D. Crowninshield1;
1Rush University Medical Center, Chicago, IL, 2Hospital Militar de Santiago, Santiago, CHILE.


Diametral Clearance Effect on Friction and Wear characteristics of Metal-on-Metal Articulations

M. Shen, B. Grundmann, G. Liebentritt;
Zimmer GmbH, Winterthur, SWITZERLAND.


A Novel, Single-Step Method to Separate Multiple Types of Wear Debris from Tissues or Wear Simulator Lubricants

F. Billi, P. Benya, P. Campbell, W. McGarry, H. A. McKellop, E. Ebramzadeh;
Orthopaedic Hospital and UCLA, Los Angeles, CA.


Performance of Hylamer-M in Revision Total Knee Arthroplasty

J-M. Brandt1, C. Young2, D. Naudie2, S. MacDonald2, C. Rorabeck2;
1University of Waterloo, London, ON, CANADA, 2University of Western Ontario, London, ON, CANADA.


The Influence of Roughness on the Wettability of Retrieved Cobalt-Chromium and Zirconia Femoral Heads

M. E. Roy1, M. E. Magill2, L. A. Whiteside1, B. J. Katerberg3, J. A. Steiger3;
1Missouri Bone & Joint Research Foundation, St. Louis, MO, 2Vanderbilt University School of Medicine, Nashville, TN, 3Whiteside Biomechanics, Inc., St. Louis, MO.


Effect of Crosslinking and Femoral Material on Polyethylene Wear Debris in a Knee Simulator Model

P. Williams1, C. M. Brown1, R. Tsukamoto1, H. Shoji1, T. Nakamura2, I. C. Clarke1;
1Loma Linda University, Loma Linda, CA, 2Kyoto University, Kyoto, JAPAN.