Con-current Oral Abstract Presentations Session 8

Saturday, April 24, 2010, 3:45 pm - 5:45 pm

Applications of Nanomaterials in Medicine II (Symposia)


Biomaterials for Image-Guided Drug Delivery

K. Ferrara;

UC Davis, Davis, CA.


Tracking, Modeling and Predicting the Erosion of Fluorescently Labeled Materials Noninvasively

N. Artzi1, C. Puron2, A. B. Ramos2, A. Groothuis3, G. Sahagian4, E. R. Edelman1;

1Massachusetts Inst. of Technology, Cambridge, MA, 2Univ.t Ramon Llull, Barcelona, SPAIN, 3Concorde BioMed. Sci. and Emerging Technologies, Lexington, MA, 4Tuftes Med. Sch., Boston, MA.


Multifunctional Rare-Earth Doped Nanoparticles in Encapsulated Albumin Nanocarriers for Tumor Targeting

D. J. Naczynski, T. Andelman, D. Pal, R. Riman, C. M. Roth, P. V. Moghe;

Rutgers Univ., Piscataway, NJ.


Lipopeptides Possessing Tripeptide, not Dipeptide, Head Groups Show Efficient DNA and siRNA Delivery

X-X. Zhang, M. W. Grinstaff;

Boston Univ., Boston, MA.


In-vivo and in-vitro detection of pancreatic cancer using functionalized CuInSe/ZnS QDs with NIR emission

K. Lee, H-E. C. Bhang, J. Park, J. Galloway, A. Maitra, M. Pomper, P. Searson;

Johns Hopkins Univ., Baltimore, MD.


Effect of Corona Lengths on Magnetic Resonance Imaging Sensitivity of Superparamagnetic Polymeric Micelles

C. Khemtong, O. Togao, J. Ren, C. W. Kessinger, M. Takahashi, A. D. Sherry, J. Gao;

Univ. of Texas Southwestern Med. Ctr. at Dallas, Dallas, TX.


Embeddable fiber-based biosensors for bacterial vaginosis

V. Reukov1, V. Maximov1, A. Vertegel1, R. Burtovyy1, I. Luzinov1, K. Kornev1, A. Moore2, R. Bevins2, P. Miller2;

1Clemson Univ., Clemson, SC, 2Greenville Hosp. System, Greenville, SC.

Biomaterials for Directed Stem Cell Differentiation


Combinatorial Effects of Matrix Elasticity and Cell Shape on Mesenchymal Stem Cell Differentiation

B. J. Gill, S. Nemir, J. L. West;

Rice Univ., Houston, TX.


Embryonic Stem Cell Differentiation is Modulated by Incorporation of Biomaterials within Embryoid Bodies

A. M. Bratt-Leal1, R. L. Carpenedo1, M. D. Ungrin2, P. W. Zandstra2, T. C. McDevitt1;

1Georgia Inst. of Technology, Atlanta, GA, 2Univ. of Toronto, Toronto, ON, CANADA.


A Bilayer Construct Controls Adipose Derived Stem Cell Differentiation

S. Natesan1, G. Zhang2, T. J. Walters1, R. J. Christy1, L. Suggs3;

1US Army Inst. of Surgical Res., Fort Sam Houston, TX, 2Univ. of Akron, Akron, OH, 3Univ. of Texas at Austin, Austin, TX.


Stem Cell Reactivity to Cardiovascular-Specific Differentiation Cues is Altered in Diabetic Conditions

H. S. Zhang, J. Maivelett, R. Stowers, M. E. Tedder, D. T. Simionescu, A. Simionescu;

Clemson Univ., Clemson, SC.


ECM Mimicking Hydrogel Scaffolds for Efficient Differentiation of Bone Marrow Stromal Cells into Various Zones of Articular Cartilage

L. H. Nguyen, A. K. Kudva, N. Saxena, K. Roy;

Univ. of Texas at Austin, Austin, TX.


Cyclodextrin-based Tuning of PEG Hydrogels for Improved Chondrogensis of Mesenchymal Stem Cells

A. Singh, Z. Ye, J. Coburn, L. Wo, J. Elisseeff;

Johns Hopkins Univ., Baltimore, MD.


Using Bioactive Gradients to Measure the Effect of Immobilized Peptide Density on Human Marrow Stromal Cell Proliferation and Differentiation

N. M. Moore1, N. J. Lin1, M. T. Cicerone1, M. L. Becker2;

1Natl. Inst. of Standards and Technology, Gaithersburg, MD, 2Univ. of Akron, Akron, OH.


Growth and Differentiation of Human Mesenchymal Stem Cells in Polymer-Peptide Hydrogels that Undergo Cell-Mediated Degradation

S. B. Anderson, M. J. Kissler, K. S. Anseth;

Univ. of Colorado, Boulder, CO.

Cancer Drug Delivery


Chimeric Polypeptide-Doxorubicin Conjugates Self-Assemble into Nanoparticles and Abolish Tumors after A Single Injection

M. CHEN1, J. A. MacKey2, J. R. .McDaniel1, T. Chu1, W. Liu1, A. J. Simnick1, A. Chilkoti1;

1Duke Univ., DURHAM, NC, 2Univ. OF Southern California, Los angeles, CA.


Theranostic Polymer Micelles for Targeted Imaging and Therapy of Lung Cancer

G. Huang;

UT Southwestern Med. Ctr., Dallas, TX.


Uptake of pro-apoptotic peptide amphiphiles by SJSA-1 cells in vitro induces specific cell death

D. Missirlis, M. Tirrell;

Univ. of California, Berkeley, Berkeley, CA.


Mechanistic Study of Biologic Intracellular Delivery with pH-Responsive Polymers

G. Y. Berguig, A. C. Convertine, C. L. Duvall, A. S. Hoffman, P. S. Stayton;

Univ. of Washington, Seattle, WA.


Prodrug Forming High Drug Loading Multifunctional Nanocapsules

Y. Shen1, E. Jin2, B. Zhang2, C. J. Murphy2, J. Tang1, M. Sui1, H. Tang2, M. Fan2, E. Van Kirk2, W. J. Murdoch2;

1Zhejiang Univ., Hangzhou, CHINA, 2Univ. of Wyoming, Laramie, WY.


Surface-Modified Monocytes Coupled to PAMAM Dendrimers for Targeted Anticancer Drug Delivery

C. A. Holden, Q. Yuan, W. Yeudall, D. Lebman, H. Yang;

Virginia Commonwealth Univ., Richmond, VA.


Characterization of in vivo drug release from in situ forming drug delivery implants

R. B. Patel1, L. Solorio1, H. Wu2, T. M. Krupka1, A. A. Exner1;

1Case Western Reserve Univ., Cleveland, OH, 2Case Western Reserve Univ. Med. Ctr., Cleveland, OH.


Nanospheric Chemotherapeutic and Chemoprotective Agents

L. Sheihet1, O. B. Garbuzenko2, T. Minko3, J. Kohn1;

1Rutgers Univ., New Jersey Ctr. for Biomaterials, Piscataway, NJ, 2Rutgers Univ., Ernest Mario Sch. of Pharmacy, Piscataway, NJ, 3Rutgers Univ., Ernest Mario Sch. of Pharmacy and NJ Ctr. for Biomaterials, Piscataway, NJ.

Cardiovascular Materials and Polyurethane Biomaterials (Symposia)


Cardiovascular Biomaterials and Polyurethanes: Issues and Perspectives

J. M. Anderson1, B. Jao1, E. Cosgriff-Hernandez2;

1Case Western Reserve Univ., Cleveland, OH, 2Texas A&M Univ., College Station, TX.


In Vivo Kinetic Degradation Analysis and Biocompatibility of Aliphatic Polyester Polyurethanes

P. T. Knight1, J. T. Kirk1, J. M. Anderson1, P. T. Mather2;

1Case Western Reserve Univ., Cleveland, OH, 2Syracuse Univ., Syracuse, NY.


Synthesis, processing and characterization of a biodegradable, elastomeric poly(ester-carbonate urethane) urea (PECUU) for soft tissue engineering

Y. Hong, J. Guan, K. Fujimoto, R. Hashizumi, A. L. Pelinescu, W. R. Wagner;

Univ. of Pittsburgh, Pittsburgh, PA.


Delivery of a collagen binding FGF-1 chimera from collagen hydrogels enhances smooth muscle cell proliferation

Y. Pang1, X. Wang2, A. A. Ucuzian3, E. M. Brey4, H. P. Greisler5;

1Illinois Inst. of Technology, Hines, IL, 2Xi’an Jiaotong Univ., Xi'an, CHINA, 3Loyola Univ. Med. Ctr., Maywood, IL, 4Illinois Inst. of Technology, Chicago, IL, 5loyola Uiniversity Med. Ctr., Maywood, IL.


Testing the in vivo compatibility and biodegradation of a degradable-polar/hydrophobic/ionic polyurethane for vascular tissue engineering applications

J. E. McBane1, K. Cai1, L. A. Matheson2, S. Sharifpoor1, R. S. Labow2, J. P. Santerre1;

1Univ. of Toronto, Toronto, ON, CANADA, 2Univ. of Ottawa Heart Inst., Ottawa, ON, CANADA.


Tunable and Injectable Hyaluronic Acid Hydrogels to Attenuate Post-Infarction Left Ventricular Remodeling

J. L. Ifkovits, E. Tous, M. Minakawa, M. Morita, J. H. Gorman, R. C. Gorman, J. A. Burdick;

Univ. of Pennsylvania, Philadelphia, PA.


Surface Modification with PEG and Hirudin for Protein Resistance and Thrombin Neutralization in Blood Contact

S. Alibeik, S. Zhu, J. Brash;

McMaster Univ., Hamilton, ON, CANADA.

Engineered Disease Models for Basic Research and Drug Discovery


Engineered Polystyrene Scaffolds For In Vitro Three-Dimensional Disease Models

M. K. Bergenstock1, W. Lau1, W. Sun2, Q. Liu1;

13D Biotek, North Brunswick, NJ, 2Drexel Univ., Philadelphia, PA.


Bisphosphonate Effects on Breast Cancer Colonization of Three-Dimensional Osteoblastic Tissue

G. N. Miller, V. Krishnan, A. M. Mastro, E. A. Vogler;

The Pennsylvania State Univ., University Park, PA.


Regulation of Cardiomyocyte Hypertrophy by Scaffold Stiffness, Ligand Presentation, and Co-culture

R. Boyer, K. Masters;

Univ. of Wisconsin-Madison, Madison, WI.


A novel 3D cell culture system could postpone primary hepatocytes dedifferentiation in vitro

M. Huihui, H. Yannan, H. Kanghong;

Inst. of Virology, Chinese Academy of Sci., 430071 Wuhan, PR China, Wuhan,Hubei, CHINA.


Harnessing Cellular Manipulation of the Cell-Matrix Interface to Control Stem Cell Fate

N. Huebsch, P. R. Arany, A. S. Mao, D. Shvartsman, O. A. Ali, J. Rivera-Feliciano, D. J. Mooney;

Harvard Univ., Cambridge, MA.


Anastellin irreversibly alters the mechanical properties of extracellular matrix fibronectin fibers

R. Andresen Eguiluz1, M. L. Smith2, E. Klotzsch3, V. Vogel3, D. Gourdon1;

1Cornell Univ., Ithaca, NY, 2Boston Univ., Boston, MA, 3Swiss Federal Inst. of Technology, Zurich, SWITZERLAND.


A microfluidic tumor model to study the effects of oxygen level and 3-D culture on tumor angiogenesis

S. S. Verbridge, N. Choi, Y. Zheng, D. J. Brooks, A. D. Stroock, C. Fischbach;

Cornell Univ., Ithaca, NY.


Engineered Tumor as an in Vitro Platform for the Assessment of Nanoparticle Drug Delivery System

L. A. Gurski1, X. Wang1, A. K. Jha1, M. C. Farach-Carson2, X. Jia1;

1Univ. of Delaware, Newark, DE, 2Rice Univ., Houston, TX.