Con-current Oral Abstract Presentations Session 2

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Biologically Inspired Biomaterials Approaches for Cancer Research


Cooperative Nanomaterial System to Sensitize, Target, and Treat Tumors

J. Park1, G. von Maltzahn2, E. Ruoslahti3, S. N. Bhatia2, M. J. Sailor4;

1Korea Advanced Inst. of Sci. and Technology, Daejeon, KOREA, REPUBLIC OF, 2Massachusetts Inst. of Technology, Cambridge, MA, 3Sanford-Burnham Med. Res. Inst. at UCSB, Santa Barbara, CA, 4Univ. of California, San Diego, La Jolla, CA.


Studying Matrix-Derived Metastatic Cues in a Biomimetic Hydrogel System

B. J. Gill1, J. E. Saik1, Z. H. Rizvi2, D. L. Gibbons2, J. M. Kurie2, J. L. West1;

1Rice Univ., Houston, TX, 2M.D. Anderson Cancer Ctr., Houston, TX.


Nanoscale Properties of Hydroxyapatite Influence Osteolytic Activity of Metastatic Breast Cancer

S. P. Pathi, D. Lin, L. Estroff, C. Fischbach;

Cornell Univ., Ithaca, NY.


Tumor Engineering: The Use of Synthetic Scaffolds to Study Prostate Tumorigenesis

T. J. Long, C. C. Sprenger, S. R. Plymate, B. D. Ratner;

Univ. of Washington, Seattle, WA.


Efficient In-Vivo Photothermal Therapy of Gold Nanorod-Loaded, Functional Nano-Carriers

W. Choi1, J-Y. Kim1, C. Kang2, C. Byeon3, Y. Kim1, G. Tae1;

1Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF, 2Advanced Photonics Res. Inst., Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF, 3Kyungpook Natl. Univ., Daegu, KOREA, REPUBLIC OF.


Inducing Tumor Cell Migration to Apoptotic Hydrogels Using Topographical Cues

A. Jain, D. Bhaumik, R. V. Bellamkonda;

Georgia Inst. of Technology, Atlanta, GA.


Adipose Progenitor Cells Regulate Fibronectin Matrix Assembly And Stiffness In Breast Tumors

E. M. Chandler, M. Saunders, D. Gourdon, C. Fischbach;

Cornell Univ., Ithaca, NY.


Recapitulating Tumor Micro-Environment In Biomaterial Based-3D In-Vitro Tumor Models

N. Arya1, V. Sardana1, M. Saxena2, A. Rangarajan2, D. Katti1;

1Indian Inst. of Technology - Kanpur, Kanpur, INDIA, 2Indian Inst. of Sci., Bangalore, INDIA.

Dynamically Responsive Biomaterials


Caged RGD-Presenting Hydrogels for the Dynamic, In Vivo Display of Adhesion Ligands

T. T. Lee1, E. A. Phelps1, M. Wirkner2, A. del Campo2, A. Garcia1;

1Georgia Instistute of Technology, Atlanta, GA, 2Max-Planck-Inst. fur Polymerforschung, Mainz, GERMANY.


Photodegradable Microparticles for Spatiotemporal Control of Growth Factor Delivery

M. W. Tibbitt1, A. M. Kloxin2, B. W. Han1, K. S. Anseth2;

1Univ. of Colorado, Boulder, CO, 2Univ. of Colorado and Howard Hughes Med. Inst., Boulder, CO.


Dynamically Drug-Responsive Biomaterials

R. G├╝beli, W. Weber;

Univ. of Freiburg, Freiburg, GERMANY.


Stimuli-Sensitive Hydrogels for Reactive Oxygen Species-Mediated Controlled Degradation and Release

S. S. Yu, A. L. Zachman, R. L. Koblin, L. H. Hofmeister, T. D. Giorgio, H-J. Sung;

Vanderbilt Univ., Nashville, TN.


Externally-Triggered Nanoparticle Composite Membranes For Drug Delivery

B. P. Timko1, T. Hoare2, J. Santamaria3, G. F. Goya3, S. Irusta3, D. Lin1, S. Lau1, R. Langer1, D. S. Kohane4;

1MIT, Cambridge, MA, 2McMaster Univ., Hamilton, ON, CANADA, 3Univ. of Zaragoza, Zaragoza, SPAIN, 4Children's Hosp. Boston, Harvard Med. Sch., Boston, MA.


Thioketal Nanoparticles Target Orally Delivered siRNA to Inflamed Intestinal Tissues and Suppress Intestinal Inflammation

D. S. Wilson, N. Murthy;

Georgia Inst. of Technology, Atlanta, GA.


Three Dimensional poly-N-isopropylacrylamide Constructs for Culture and Harvesting of Muscle Fibers

S. J. DuPont, Jr., K. Elineni, N. D. Gallant, R. Toomey;

Univ. of South Florida, Tampa, FL.


Pulsatile Drug Delivery from Poly(NIPAAm-co-AAm)- Gold Nanoshell Composites

L. E. Strong, M. Bikram, J. L. West;

Rice Univ., Houston, TX.

Macrophage-centered Host Response to Biomaterials and Wound Healing (Symposium)


Macrophage-centered Host Response to Biomaterials and Wound Healing

S. F. Badylak;

Univ. of Pittsburgh, Pittsburgh, PA.


Imaging of Biomaterial-Associated Inflammation Using Hydrocyanine Dyes

S. Selvam1, K. Kundu2, K. L. Templeman1, N. Murthy2, A. J. Garcia1;

1Woodruff Sch. of Mechanical Engineering, Georgia Inst. of Technology, Atlanta, GA, 2Wallace H. Coulter Dept. of BioMed. Engineering, Georgia Inst. of Technology, Atlanta, GA.


PEG-Based Hydrogels Modulate Reactive Oxygen Species Release and Cellular Death of Primary Phagocytes

H. Waldeck1, X. Wang2, W. Kao1;

1Univ. of Wisconsin - Madison, Madison, WI, 2Univ. of Minnesota, Minneapolis, MN.


Poly(Methacrylic Acid -Co- Methyl Methacrylate) Beads, But Not Poly(Methyl Methacrylate) Beads, Increased Blood Vessel Counts and Sonic Hedgehog Expression in Diabetic Wound Healing

L. E. Fitzpatrick, M. V. Sefton;

Univ. of Toronto, Toronto, ON, CANADA.


Bioluminescent Imaging of Biomaterial-induced Reactive Oxygen Species

W. F. Liu1, M. Ma2, K. M. Bratlie2, T. T. Dang2, R. Langer2, D. G. Anderson2;

1Univ. of California, Irvine, Irvine, CA, 2Massachusetts Inst. of Technology, Cambridge, MA.


Macrophage Polarity In The Foreign Body Reaction Is Substrate-Specific

E. M. Sussman, B. D. Ratner;

Univ. of Washington, Seattle, WA.


Macrophage Phenotype as a Determinant of Remodeling Outcome with the use of Biologic Scaffolds

S. F. Badylak1, K. Kukla1, L. Zhang1, N. Turner1, B. Brown2;

1Univ. of Pittsburgh, Pittsburgh, PA, 2Cornell Univ., Ithaca, NY.

Propelling Materials Into the Clinic (Symposium)


Biomaterials: A FDA Perspective

D. Patwardhan;

FDA, Silver Spring, MD.


Translation of Antibody-Polysaccharide Conjugates to Treating Burns in the Clinic

N. Washburn, L. Sun;

Carnegie Mellon Univ., Pittsburgh, PA.


Dermal Integration Cuff Improves Resistance to Exit Site Infections in Porcine Bacterial Challenge

A. J. Marshall1, A. Nieponice2, M. Alvarez1, M. G. Maginness1;

1Healionics, Seattle, WA, 2Univ. Favaloro, Buenos Aires , ARGENTINA.


Clinical Translation of a Keratin Biomaterial Hydrogel for Nerve Repair

L. A. Pace, P. Hill, J. Garrett, J. Ma, P. Apel, S. Mannava, J. Barnwell, B. Smith, Z. Li, L. Koman, T. Smith, M. Van Dyke;

Wake Forest Univ., Winston-Salem, NC.


A Novel Polycarbonate-Urethane Meniscal Implant: From Bench to First Clinical Experience

J. J. Elsner1, G. Zur1, V. Condello2, C. Zorzi2, R. Arbel3, E. B. Hershman4, F. Guilak5, A. Shterling1, E. Linder-Ganz1;

1Active Implants Corp., Netanya, ISRAEL, 2Sacro Cuore Don Calabria Hosp., Verona, ITALY, 3Tel-Aviv Sourasky Med. Ctr., Tel-Aviv, ISRAEL, 4Lenox Hill Hosp., New York, NY, 5Duke Univ. Med. Ctr., Durham, NC.


Pressure Generation as a Metric to Evaluate Vascular Graft Thrombogenicity In Vitro

M. D. Nichols;

Duke Univ., Durham, NC.


Vascular Restoration Therapy: Method to Improve Performance of Fully Bioabsorbable Vascular Stent to Replace Current Metallic Drug Eluting Stent

Y. Wang;

Abbott Vascular, Sunnyvale, CA.

Scaffold Assisted Bone Defect Repair / Regeneration


Bone Extracellular Matrix-Mimicking Self-Assembled Biphasic Nanomatrix for Bone Tissue Regeneration

J. Anderson, J. Vines, J. Patterson, S. Gilbert, A. Javed, H-W. Jun;

Univ. of Alabama at Birmingham, Birmingham, AL.


Effect of Hydroxyapatite-Coated PLLA and PCL Porous Scaffolds on Bone Formation In Vivo

E. Saito1, D. Suarez-Gonzalez2, W. Murphy2, S. Hollister1;

1Univ. of Michigan, Ann Arbor, MI, 2Univ. of Wisconsin, Madison, WI.


Design and Characterization of Fully Osteoconductive Scaffolds for Homogeneous and Enhanced Bone Regeneration

A. R. Amini, C. T. Laurencin, S. P. Nukavarapu;

Univ. of Connecticut Hlth.Ctr., Farmington, CT.


Calcium Alginate Porogens for the Development of an Injectable Paste To Treat Traumatic Fractures

R. M. Buchanan1, M. B. Murphy1, D. M. Yoon2, A. M. Henslee2, M. Nair2, F. K. Kasper2, P. J. Simmons3, A. G. Mikos1, M. Ferrari1, E. Tasciotti1;

1The Methodist Hosp. Res. Inst., Houston, TX, 2Rice Univ., Houston, TX, 3The Univ. of Texas Hlth.Sci. Ctr. Houston, Houston, TX.


Evaluation of the Osteogenic Activity of Injectable Bovine Lactoferrin Gel

A. Amini, L. S. Nair;

Univ. of Connecticut Hlth.Ctr., Farmington, CT.


Effect of Rapidly Resorbable Calcium-Alkali-Phosphate Bone Grafting Materials for Alveolar Ridge Augmentation on Bone Formation and Osteoblastic Phenotype Expression In Vivo

C. Knabe1, G. Berger2, R. Gildenhaar2, S. Jonscher1, A. Bednarek1, C. Koch1, A. Rack3, M. Stiller1;

1Charite Univ. Med. Ctr., Berlin, GERMANY, 2Federal Inst. for Materials Res. and Testing, Berlin, GERMANY, 3European Synchroton Facility, Grenoble, FRANCE.


Hydrogel Microencapslation Permits Critical Size Defect Repair Via Gene Therapy

R. M. R. Olabisi1, C. Sonnet2, C. L. Simpson1, Z. Lazard2, K. Sullivan2, A. R. Davis2, J. L. West1, E. A. Davis2;

1Rice Univ., Houston, TX, 2Baylor Coll. of Med., Houston, TX.


Does Bone Marrow Aspirate Augment Bone Formation with a Hydroxyapatite Scaffold?

M. J. Coathup1, W-J. Lo2, T. Edwards1, G. W. Blunn1;

1Univ. Coll. London, Stanmore, Middlesex, UNITED KINGDOM, 2Orthogem Ltd, Nottingham, UNITED KINGDOM.