Con-current Oral Abstract Presentations Session 2

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Biologically Inspired Biomaterials Approaches for Cancer Research

Cooperative Nanomaterial System to Sensitize, Target, and Treat Tumors

J. Park¹, G. von Maltzahn², E. Ruoslahti³, S. N. Bhatia², M. J. Sailor⁴;

¹Korea Advanced Inst. of Sci. and Technology, Daejeon, KOREA, REPUBLIC OF, ²Massachusetts Inst. of Technology, Cambridge, MA, ³Sanford-Burnham Med. Res. Inst. at UCSB, Santa Barbara, CA, ⁴Univ. of California, San Diego, La Jolla, CA.

Studying Matrix-Derived Metastatic Cues in a Biomimetic Hydrogel System

B. J. Gill¹, J. E. Saik¹, Z. H. Rizvi², D. L. Gibbons², J. M. Kurie², J. L. West¹;

¹Rice Univ., Houston, TX, ²M.D. Anderson Cancer Ctr., Houston, TX.

Nanoscale Properties of Hydroxyapatite Influence Osteolytic Activity of Metastatic Breast Cancer

S. P. Pathi, D. Lin, L. Estroff, C. Fischbach;

Cornell Univ., Ithaca, NY.

Tumor Engineering: The Use of Synthetic Scaffolds to Study Prostate Tumorigenesis

T. J. Long, C. C. Sprenger, S. R. Plymate, B. D. Ratner;

Univ. of Washington, Seattle, WA.

Efficient In-Vivo Photothermal Therapy of Gold Nanorod-Loaded, Functional Nano-Carriers

W. Choi¹, J-Y. Kim¹, C. Kang², C. Byeon³, Y. Kim¹, G. Tae¹;

¹Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF, ²Advanced Photonics Res. Inst., Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF, ³Kyungpook Natl. Univ., Daegu, KOREA, REPUBLIC OF.

Inducing Tumor Cell Migration to Apoptotic Hydrogels Using Topographical Cues

A. Jain, D. Bhaumik, R. V. Bellamkonda;

Georgia Inst. of Technology, Atlanta, GA.

Adipose Progenitor Cells Regulate Fibronectin Matrix Assembly And Stiffness In Breast Tumors

E. M. Chandler, M. Saunders, D. Gourdon, C. Fischbach;

Cornell Univ., Ithaca, NY.

Recapitulating Tumor Micro-Environment In Biomaterial Based-3D In-Vitro Tumor Models

N. Arya¹, V. Sardana¹, M. Saxena², A. Rangarajan², D. Katti¹;

¹Indian Inst. of Technology - Kanpur, Kanpur, INDIA, ²Indian Inst. of Sci., Bangalore, INDIA.

Dynamically Responsive Biomaterials

Caged RGD-Presenting Hydrogels for the Dynamic, In Vivo Display of Adhesion Ligands

T. T. Lee¹, E. A. Phelps¹, M. Wirkner², A. del Campo², A. Garcia¹;

¹Georgia Instistute of Technology, Atlanta, GA, ²Max-Planck-Inst. fur Polymerforschung, Mainz, GERMANY.

Photodegradable Microparticles for Spatiotemporal Control of Growth Factor Delivery

M. W. Tibbitt¹, A. M. Kloxin², B. W. Han¹, K. S. Anseth²;

¹Univ. of Colorado, Boulder, CO, ²Univ. of Colorado and Howard Hughes Med. Inst., Boulder, CO.

Dynamically Drug-Responsive Biomaterials

R. Gübeli, W. Weber;

Univ. of Freiburg, Freiburg, GERMANY.

Stimuli-Sensitive Hydrogels for Reactive Oxygen Species-Mediated Controlled Degradation and Release

S. S. Yu, A. L. Zachman, R. L. Koblin, L. H. Hofmeister, T. D. Giorgio, H-J. Sung;

Vanderbilt Univ., Nashville, TN.

Externally-Triggered Nanoparticle Composite Membranes For Drug Delivery

B. P. Timko¹, T. Hoare², J. Santamaria³, G. F. Goya³, S. Irusta³, D. Lin¹, S. Lau¹, R. Langer¹, D. S. Kohane⁴;

¹MIT, Cambridge, MA, ²McMaster Univ., Hamilton, ON, CANADA, ³Univ. of Zaragoza, Zaragoza, SPAIN, ⁴Children's Hosp. Boston, Harvard Med. Sch., Boston, MA.

Thioketal Nanoparticles Target Orally Delivered siRNA to Inflamed Intestinal Tissues and Suppress Intestinal Inflammation

D. S. Wilson, N. Murthy;

Georgia Inst. of Technology, Atlanta, GA.

Three Dimensional poly-N-isopropylacrylamide Constructs for Culture and Harvesting of Muscle Fibers

S. J. DuPont, Jr., K. Elineni, N. D. Gallant, R. Toomey;

Univ. of South Florida, Tampa, FL.

Pulsatile Drug Delivery from Poly(NIPAAm-co-AAm)- Gold Nanoshell Composites

L. E. Strong, M. Bikram, J. L. West;

Rice Univ., Houston, TX.

Macrophage-centered Host Response to Biomaterials and Wound Healing (Symposium)

Macrophage-centered Host Response to Biomaterials and Wound Healing

S. F. Badylak;

Univ. of Pittsburgh, Pittsburgh, PA.

Imaging of Biomaterial-Associated Inflammation Using Hydrocyanine Dyes

S. Selvam¹, K. Kundu², K. L. Templeman¹, N. Murthy², A. J. Garcia¹;

¹Woodruff Sch. of Mechanical Engineering, Georgia Inst. of Technology, Atlanta, GA, ²Wallace H. Coulter Dept. of BioMed. Engineering, Georgia Inst. of Technology, Atlanta, GA.

PEG-Based Hydrogels Modulate Reactive Oxygen Species Release and Cellular Death of Primary Phagocytes

H. Waldeck¹, X. Wang², W. Kao¹;

¹Univ. of Wisconsin - Madison, Madison, WI, ²Univ. of Minnesota, Minneapolis, MN.

Poly(Methacrylic Acid -Co- Methyl Methacrylate) Beads, But Not Poly(Methyl Methacrylate) Beads, Increased Blood Vessel Counts and Sonic Hedgehog Expression in Diabetic Wound Healing

L. E. Fitzpatrick, M. V. Sefton;

Univ. of Toronto, Toronto, ON, CANADA.

Bioluminescent Imaging of Biomaterial-induced Reactive Oxygen Species

W. F. Liu¹, M. Ma², K. M. Bratlie², T. T. Dang², R. Langer², D. G. Anderson²;

¹Univ. of California, Irvine, Irvine, CA, ²Massachusetts Inst. of Technology, Cambridge, MA.

Macrophage Polarity In The Foreign Body Reaction Is Substrate-Specific

E. M. Sussman, B. D. Ratner;

Univ. of Washington, Seattle, WA.

Macrophage Phenotype as a Determinant of Remodeling Outcome with the use of Biologic Scaffolds

S. F. Badylak¹, K. Kukla¹, L. Zhang¹, N. Turner¹, B. Brown²;

¹Univ. of Pittsburgh, Pittsburgh, PA, ²Cornell Univ., Ithaca, NY.

Propelling Materials Into the Clinic (Symposium)

Biomaterials: A FDA Perspective

D. Patwardhan;

FDA, Silver Spring, MD.

Translation of Antibody-Polysaccharide Conjugates to Treating Burns in the Clinic

N. Washburn, L. Sun;

Carnegie Mellon Univ., Pittsburgh, PA.

Dermal Integration Cuff Improves Resistance to Exit Site Infections in Porcine Bacterial Challenge

A. J. Marshall¹, A. Nieponice², M. Alvarez¹, M. G. Maginness¹;

¹Healionics, Seattle, WA, ²Univ. Favaloro, Buenos Aires , ARGENTINA.

Clinical Translation of a Keratin Biomaterial Hydrogel for Nerve Repair

L. A. Pace, P. Hill, J. Garrett, J. Ma, P. Apel, S. Mannava, J. Barnwell, B. Smith, Z. Li, L. Koman, T. Smith, M. Van Dyke;

Wake Forest Univ., Winston-Salem, NC.

A Novel Polycarbonate-Urethane Meniscal Implant: From Bench to First Clinical Experience

J. J. Elsner¹, G. Zur¹, V. Condello², C. Zorzi², R. Arbel³, E. B. Hershman⁴, F. Guilak⁵, A. Shterling¹, E. Linder-Ganz¹;

¹Active Implants Corp., Netanya, ISRAEL, ²Sacro Cuore Don Calabria Hosp., Verona, ITALY, ³Tel-Aviv Sourasky Med. Ctr., Tel-Aviv, ISRAEL, ⁴Lenox Hill Hosp., New York, NY, ⁵Duke Univ. Med. Ctr., Durham, NC.

Pressure Generation as a Metric to Evaluate Vascular Graft Thrombogenicity In Vitro

M. D. Nichols;

Duke Univ., Durham, NC.

Vascular Restoration Therapy: Method to Improve Performance of Fully Bioabsorbable Vascular Stent to Replace Current Metallic Drug Eluting Stent

Y. Wang;

Abbott Vascular, Sunnyvale, CA.

Scaffold Assisted Bone Defect Repair / Regeneration

Bone Extracellular Matrix-Mimicking Self-Assembled Biphasic Nanomatrix for Bone Tissue Regeneration

J. Anderson, J. Vines, J. Patterson, S. Gilbert, A. Javed, H-W. Jun;

Univ. of Alabama at Birmingham, Birmingham, AL.

Effect of Hydroxyapatite-Coated PLLA and PCL Porous Scaffolds on Bone Formation In Vivo

E. Saito¹, D. Suarez-Gonzalez², W. Murphy², S. Hollister¹;

¹Univ. of Michigan, Ann Arbor, MI, ²Univ. of Wisconsin, Madison, WI.

Design and Characterization of Fully Osteoconductive Scaffolds for Homogeneous and Enhanced Bone Regeneration

A. R. Amini, C. T. Laurencin, S. P. Nukavarapu;

Univ. of Connecticut Hlth.Ctr., Farmington, CT.

Calcium Alginate Porogens for the Development of an Injectable Paste To Treat Traumatic Fractures

R. M. Buchanan¹, M. B. Murphy¹, D. M. Yoon², A. M. Henslee², M. Nair², F. K. Kasper², P. J. Simmons³, A. G. Mikos¹, M. Ferrari¹, E. Tasciotti¹;

¹The Methodist Hosp. Res. Inst., Houston, TX, ²Rice Univ., Houston, TX, ³The Univ. of Texas Hlth.Sci. Ctr. Houston, Houston, TX.

Evaluation of the Osteogenic Activity of Injectable Bovine Lactoferrin Gel

A. Amini, L. S. Nair;

Univ. of Connecticut Hlth.Ctr., Farmington, CT.

Effect of Rapidly Resorbable Calcium-Alkali-Phosphate Bone Grafting Materials for Alveolar Ridge Augmentation on Bone Formation and Osteoblastic Phenotype Expression In Vivo

C. Knabe¹, G. Berger², R. Gildenhaar², S. Jonscher¹, A. Bednarek¹, C. Koch¹, A. Rack³, M. Stiller¹;

¹Charite Univ. Med. Ctr., Berlin, GERMANY, ²Federal Inst. for Materials Res. and Testing, Berlin, GERMANY, ³European Synchroton Facility, Grenoble, FRANCE.

Hydrogel Microencapslation Permits Critical Size Defect Repair Via Gene Therapy

R. M. R. Olabisi¹, C. Sonnet², C. L. Simpson¹, Z. Lazard², K. Sullivan², A. R. Davis², J. L. West¹, E. A. Davis²;

¹Rice Univ., Houston, TX, ²Baylor Coll. of Med., Houston, TX.

Does Bone Marrow Aspirate Augment Bone Formation with a Hydroxyapatite Scaffold?

M. J. Coathup¹, W-J. Lo², T. Edwards¹, G. W. Blunn¹;

¹Univ. Coll. London, Stanmore, Middlesex, UNITED KINGDOM, ²Orthogem Ltd, Nottingham, UNITED KINGDOM.