Con-current Oral Abstract Presentations Session 6

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Biomimetic Materials for Tissue Engineering

207

Patterned hMSC Differentiation in 3D Hydrogels Based on Network Structures

S. Khetan, J. A. Burdick;

Univ. of Pennsylvania, Philadelphia, PA.

208

A Modular, Hydroxyapatite-Binding Version of Vascular Endothelial Growth Factor

J. Lee¹, A. J. Wagoner Johnson², W. L. Murphy¹;

¹Univ. of Wisconsin, Madison, WI, ²Univ. of Illinois, Urbana, IL.

209

GFOGER Peptide-Modified Matrices Support Osteogenic Differentiation and Bone Formation

A. Shekaran;

Georgia Inst. of Technology, Atlanta, GA.

210

In Search of an Endothelial Cell Selective Surface for Modifying ePTFE Grafts

L. Dudash¹, F. Kligman², K. Kapalka¹, K. Kottke-Marchant², R. Marchant¹;

¹Case Western Reserve Univ., Cleveland, OH, ²Cleveland Clinic, Cleveland, OH.

211

Engineered PEG Hydrogels with Enhanced Proteolytic Degradation for Presentation of Angiogenic Signals

J. Patterson, J. A. Hubbell;

Ecole Polytechnique Federale de Lausanne, Lausanne, SWITZERLAND.

212

Composite Hydrogel-Ceramic Scaffold Optimization for the Regeneration of the Cartilage-Bone Interface

M. K. Boushell, N. T. Khanarian, H. H. Lu;

Columbia Univ., New York, NY.

213

Non-Invasive In Vivo Evaluation of 3-D Cell Proliferation in the In Situ Cross-Linkable Gelatin Hydrogels with Different Matrix Stiffness

K. Park¹, D. Hwang², H. Shim², Y. Joung¹, H. Youn², D. Lee², K. Park¹;

¹Ajou Univ., Suwon, KOREA, REPUBLIC OF, ²Seoul Natl. Univ. Coll. of Med., Seoul, KOREA, REPUBLIC OF.

214

Cell-Cell Communication Mimicry with PEG Hydrogels for Enhancing Beta-Cell Function

C-C. Lin¹, K. S. Anseth²;

¹Indiana Univ.-Purdue Univ. at Indianapolis, Indianapolis, IN, ²Univ. of Colorado at Boulder, Boulder, CO.

Cellular Responses to Biophysical Cues

215

Substrate Rigidity Modulates EMT: Implications in Biomaterials-Associated Fibrosis

A. C. Brown, V. F. Fiore, J. Chen, T. H. Barker;

Georgia Inst. of Technology, Atlanta, GA.

216

Endothelial Cell -Substratum Interactions Control Monocyte Adhesion Through a Src and MCP-1 Mediated Pathway

L. Indolfi¹, A. B. Baker², E. R. Edelman¹;

¹MIT, Cambridge, MA, ²The Univ. of Texas at Austin, Austin, TX.

217

Substrate Stiffness Affects Cardiomyocyte Action Potential

J. G. Jacot, J. D. Myers;

Rice Univ., Houston, TX.

218

Defining Matrix Composition to Promote In Vitro Growth and Expansion of Intestinal Organoids

J. Su, K. Yan, C. J. Kuo, S. C. Heilshorn;

Stanford Univ., Stanford, CA.

219

Adhesion Site Manipulation Using Multifaceted Micropatterned Surfaces Created with Laser Scanning Lithography

J. H. Slater, J. L. West;

Rice Univ., Houston, TX.

220

Controlled Reaggregation of Pancreatic ß-cells Promotes Viability and Functional Expression

A. B. Bernard¹, C-C. Lin², K. S. Anseth¹;

¹Univ. of Colorado, Boulder, CO, ²Indiana Univ.-Purdue Univ. at Indianapolis, Indianapolis, IN.

221

β1-integrin Cytoskeleton Signaling Regulates Sensory Neurons Response to Matrix Dimensionality

A. S. Ribeiro¹, D. Hughes¹, S. Vargo¹, J. B. Leach¹, E. M. Powell²;

¹Univ. of Maryland Baltimore County, Baltimore, MD, ²Univ. of Maryland Sch. of Med., Baltimore, MD.

222

Controlling Cell Adhesion Through Dynamic Ligand Presentation

A. Kourouklis, R. Lerum, H. Bermudez;

Univ. of Massachusetts, Amherst, MA.

Engineering Therapeutic Delivery from Biomaterial Scaffolds

223

Novel Antibiotic-Eluting Wound Dressings: In-Vitro and In-Vivo Study and Engineering Aspects in the Dressing's Design

J. J. Elsner¹, D. Egozi², Y. Ullman², I. Berdicevsky³, A. Shefy-Peleg¹, M. Zilberman¹;

¹Tel Aviv Univ., Ramat Aviv, ISRAEL, ²2Dept of Plastic Surgery and Burn Unit, Rambam Med. Ctr., Haifa, ISRAEL, ³Faculty of Med., Technion – Israel Inst. of Technology, Haifa, ISRAEL.

224

Effect of PEG Modification on the Transport of Epidermal Growth Factor in the Stroke-Injured Brain

Y. Wang, M. J. Cooke, C. M. Morshead, M. S. Shoichet;

Univ. of Toronto, Toronto, ON, CANADA.

225

DNA Polyplex Loaded Hyaluronic Acid Hydrogel Scaffolds for Local Gene Transfer

S. Gojgini, T. Tokatlian, Y. Lei, T. Segura;

Univ. of California Los Angeles, Los Angeles, CA.

226

Nonviral Vector Delivery from T904/Fibrinogen Hydrogels

J. Zhang, A. Sen, E. Cho, J. Lee, K. Webb;

Clemson Univ., Clemson, SC.

227

"Smart," Sustained Local Delivery of siRNA from an Injectable Scaffold

C. E. Nelson, M. K. Gupta, E. J. Adolph, S. A. Guelcher, C. L. Duvall;

Vanderbilt Univ., Nashville, TN.

228

Promotion of Myocardial Repair by Dual Delivery of IGF-1 and HGF from Injectable Alginate Biomaterial

E. Ruvinov¹, J. Leor², S. Cohen¹;

¹Ben Gurion Univ. of the Negev, Beer Sheva, ISRAEL, ²Neufeld Cardiac Res. Inst., Tel-Hashomer, ISRAEL.

229

Heparin-Decorated, Hyaluronic Acid-Based Hydrogel Particles for the Controlled Release of Bone Morphogenetic Protein 2

X. Xu, A. Jha, R. Duncan, X. Jia;

Univ. of Delaware, Newark, DE.

230

Alginate Microsphere/Hyaluronic Acid Hydrogel Composites for Controlled Delivery of TGF-β3 to Enhance Encapsulated MSC Chondrogenesis

L. Bian, D. Y. Zhai, J. A. Burdick;

Univ. of Pennsylvania, Philadelphia, PA.

Molecular Mechanisms Mediating Protein-Surface and Cell-Surface Interactions

231

Time-Dependent Conformational Changes in Adsorbed Albumin and its Effect on Platelet Adhesion

B. Sivaraman, R. Latour;

Clemson Univ., Clemson, SC.

232

Estimation of Peptide-Surface Adsorption Free Energy for Material Surfaces Not Conducive to SPR and QCM using AFM

A. A. Thyparambil, Y. Wei, R. A. Latour, Jr.;

Clemson Univ., Clemson, SC.

233

Effect of Plasma Protein Adsorption on In Vitro Activation of Dendritic Cells by Polyanhydride Microparticles

B. R. Carrillo-Conde, M. J. Wannemuehler, B. Narasimhan;

Iowa State Univ., Ames, IA.

234

Integrin-Directed Modulation of Macrophage Response to Biomaterials

T. Zaveri, J. Lewis, N. Dolgova, M. Clare-Salzler, B. Keselowsky;

Univ. of Florida, Gainesville, FL.

235

Extracellular Matrix Proteins Mediate Osteogenic Differentiation of Human Mesenchymal Stem Cells on Phosphate Functionalized Gels Through Integrin Mediated Focal Adhesion Kinase Signaling

N. R. Gandavarapu;

Univ. of Colorado, Boulder, Boulder, CO.

236

Adsorption Does Not Enhance Exposure of the Fibrinogen Gamma Chain Dodecapeptide

D. L. Elbert, V. Ovod, M. Flake, R. K. Bateman;

Washington Univ., St. Louis, MO.

237

Broad Application of a Heptaglutamate Domain to Functionalize Hydroxyapatite-Containing Biomaterials

B. K. Culpepper, A. A. Sawyer, S. L. Bellis;

Univ. of Alabama at Birmingham, Birmingham, AL.

238

von Willebrand Function and Structure Is Different When Adsorbed to Different Synthetic Materials

E. Hillenmeyer, R. Penkala, W. Thomas, D. G. Castner;

Univ. of Washington, Seattle, WA.

Scaffolds for Cardiovascular and Musculosketetal Organ Regeneration

239

On-Demand Retrieval and Evaluation of MSCs Encapsulated in Enzymatically-Degradable PEG-Based Hydrogels

P. J. Yang, J. S. Temenoff;

Georgia Inst. of Technology, Atlanta, GA.

240

Relative Influence of Collagen Concentration Versus Substrate Modulus on MSC Fate Decisions

S. Becerra-Bayona, D. Munoz-Pinto, M. S. Hahn;

Texas A&M Univ., College Station, TX.

241

Evaluation of Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels

M. Browning, E. Cosgriff-Hernandez, M. Hahn, D. Dempsey, V. Guiza, B. Russell, M. Hook, F. Clubb, M. Miller, T. Fossum;

Texas A&M Univ., College Station, TX.

242

Integration of Multiple Cell-Matrix Interactions into Alginate Scaffolds for Cardiac Tissue Regeneration

Y. Sapir, O. Kryukov, S. Cohen;

Ben-Gurion Univ. of the Negev, Beer Sheva, ISRAEL.

243

Fabrication of TiO2 Nano-Fiber Meshes by Electrospinning and Evaluation of Their Osteoblast Differentiation Potential

R. A. Gittens¹, X. Wang², R. Song¹, Z. Schwartz¹, H. Chen², B. D. Boyan¹;

¹Georgia Inst. of Technology, Atlanta, GA, ²Peking Univ., Beijing, CHINA.

244

Long-Term In Vitro Cytocompatibility of Hydrogel Nanocomposites as Injectable Bone Substitutes

L. Zhang¹, H. Fenniri², T. J. Webster³;

¹The George Washington Univ., Washington, DC, ²Univ. of Alberta, Edmonton, AB, CANADA, ³Brown Univ., Providence, RI.

245

Efficient Re-differentiation of De-differentiated Chondrocytes in Heparin-Based Hydrogel: In-vitro and In-vivo Study

M. Kim;

Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF.

246

Engineered Matrix Mimetics Support Assembly of Two Distinct Forms of Fibronectin Matrix

D. C. Roy, D. C. Hocking;

Univ. of Rochester, Rochester, NY.