Con-current Oral Abstract Presentations Session 6

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Biomimetic Materials for Tissue Engineering


Patterned hMSC Differentiation in 3D Hydrogels Based on Network Structures

S. Khetan, J. A. Burdick;

Univ. of Pennsylvania, Philadelphia, PA.


A Modular, Hydroxyapatite-Binding Version of Vascular Endothelial Growth Factor

J. Lee1, A. J. Wagoner Johnson2, W. L. Murphy1;

1Univ. of Wisconsin, Madison, WI, 2Univ. of Illinois, Urbana, IL.


GFOGER Peptide-Modified Matrices Support Osteogenic Differentiation and Bone Formation

A. Shekaran;

Georgia Inst. of Technology, Atlanta, GA.


In Search of an Endothelial Cell Selective Surface for Modifying ePTFE Grafts

L. Dudash1, F. Kligman2, K. Kapalka1, K. Kottke-Marchant2, R. Marchant1;

1Case Western Reserve Univ., Cleveland, OH, 2Cleveland Clinic, Cleveland, OH.


Engineered PEG Hydrogels with Enhanced Proteolytic Degradation for Presentation of Angiogenic Signals

J. Patterson, J. A. Hubbell;

Ecole Polytechnique Federale de Lausanne, Lausanne, SWITZERLAND.


Composite Hydrogel-Ceramic Scaffold Optimization for the Regeneration of the Cartilage-Bone Interface

M. K. Boushell, N. T. Khanarian, H. H. Lu;

Columbia Univ., New York, NY.


Non-Invasive In Vivo Evaluation of 3-D Cell Proliferation in the In Situ Cross-Linkable Gelatin Hydrogels with Different Matrix Stiffness

K. Park1, D. Hwang2, H. Shim2, Y. Joung1, H. Youn2, D. Lee2, K. Park1;

1Ajou Univ., Suwon, KOREA, REPUBLIC OF, 2Seoul Natl. Univ. Coll. of Med., Seoul, KOREA, REPUBLIC OF.


Cell-Cell Communication Mimicry with PEG Hydrogels for Enhancing Beta-Cell Function

C-C. Lin1, K. S. Anseth2;

1Indiana Univ.-Purdue Univ. at Indianapolis, Indianapolis, IN, 2Univ. of Colorado at Boulder, Boulder, CO.

Cellular Responses to Biophysical Cues


Substrate Rigidity Modulates EMT: Implications in Biomaterials-Associated Fibrosis

A. C. Brown, V. F. Fiore, J. Chen, T. H. Barker;

Georgia Inst. of Technology, Atlanta, GA.


Endothelial Cell -Substratum Interactions Control Monocyte Adhesion Through a Src and MCP-1 Mediated Pathway

L. Indolfi1, A. B. Baker2, E. R. Edelman1;

1MIT, Cambridge, MA, 2The Univ. of Texas at Austin, Austin, TX.


Substrate Stiffness Affects Cardiomyocyte Action Potential

J. G. Jacot, J. D. Myers;

Rice Univ., Houston, TX.


Defining Matrix Composition to Promote In Vitro Growth and Expansion of Intestinal Organoids

J. Su, K. Yan, C. J. Kuo, S. C. Heilshorn;

Stanford Univ., Stanford, CA.


Adhesion Site Manipulation Using Multifaceted Micropatterned Surfaces Created with Laser Scanning Lithography

J. H. Slater, J. L. West;

Rice Univ., Houston, TX.


Controlled Reaggregation of Pancreatic ß-cells Promotes Viability and Functional Expression

A. B. Bernard1, C-C. Lin2, K. S. Anseth1;

1Univ. of Colorado, Boulder, CO, 2Indiana Univ.-Purdue Univ. at Indianapolis, Indianapolis, IN.


β1-integrin Cytoskeleton Signaling Regulates Sensory Neurons Response to Matrix Dimensionality

A. S. Ribeiro1, D. Hughes1, S. Vargo1, J. B. Leach1, E. M. Powell2;

1Univ. of Maryland Baltimore County, Baltimore, MD, 2Univ. of Maryland Sch. of Med., Baltimore, MD.


Controlling Cell Adhesion Through Dynamic Ligand Presentation

A. Kourouklis, R. Lerum, H. Bermudez;

Univ. of Massachusetts, Amherst, MA.

Engineering Therapeutic Delivery from Biomaterial Scaffolds


Novel Antibiotic-Eluting Wound Dressings: In-Vitro and In-Vivo Study and Engineering Aspects in the Dressing's Design

J. J. Elsner1, D. Egozi2, Y. Ullman2, I. Berdicevsky3, A. Shefy-Peleg1, M. Zilberman1;

1Tel Aviv Univ., Ramat Aviv, ISRAEL, 22Dept of Plastic Surgery and Burn Unit, Rambam Med. Ctr., Haifa, ISRAEL, 3Faculty of Med., Technion – Israel Inst. of Technology, Haifa, ISRAEL.


Effect of PEG Modification on the Transport of Epidermal Growth Factor in the Stroke-Injured Brain

Y. Wang, M. J. Cooke, C. M. Morshead, M. S. Shoichet;

Univ. of Toronto, Toronto, ON, CANADA.


DNA Polyplex Loaded Hyaluronic Acid Hydrogel Scaffolds for Local Gene Transfer

S. Gojgini, T. Tokatlian, Y. Lei, T. Segura;

Univ. of California Los Angeles, Los Angeles, CA.


Nonviral Vector Delivery from T904/Fibrinogen Hydrogels

J. Zhang, A. Sen, E. Cho, J. Lee, K. Webb;

Clemson Univ., Clemson, SC.


"Smart," Sustained Local Delivery of siRNA from an Injectable Scaffold

C. E. Nelson, M. K. Gupta, E. J. Adolph, S. A. Guelcher, C. L. Duvall;

Vanderbilt Univ., Nashville, TN.


Promotion of Myocardial Repair by Dual Delivery of IGF-1 and HGF from Injectable Alginate Biomaterial

E. Ruvinov1, J. Leor2, S. Cohen1;

1Ben Gurion Univ. of the Negev, Beer Sheva, ISRAEL, 2Neufeld Cardiac Res. Inst., Tel-Hashomer, ISRAEL.


Heparin-Decorated, Hyaluronic Acid-Based Hydrogel Particles for the Controlled Release of Bone Morphogenetic Protein 2

X. Xu, A. Jha, R. Duncan, X. Jia;

Univ. of Delaware, Newark, DE.


Alginate Microsphere/Hyaluronic Acid Hydrogel Composites for Controlled Delivery of TGF-β3 to Enhance Encapsulated MSC Chondrogenesis

L. Bian, D. Y. Zhai, J. A. Burdick;

Univ. of Pennsylvania, Philadelphia, PA.

Molecular Mechanisms Mediating Protein-Surface and Cell-Surface Interactions


Time-Dependent Conformational Changes in Adsorbed Albumin and its Effect on Platelet Adhesion

B. Sivaraman, R. Latour;

Clemson Univ., Clemson, SC.


Estimation of Peptide-Surface Adsorption Free Energy for Material Surfaces Not Conducive to SPR and QCM using AFM

A. A. Thyparambil, Y. Wei, R. A. Latour, Jr.;

Clemson Univ., Clemson, SC.


Effect of Plasma Protein Adsorption on In Vitro Activation of Dendritic Cells by Polyanhydride Microparticles

B. R. Carrillo-Conde, M. J. Wannemuehler, B. Narasimhan;

Iowa State Univ., Ames, IA.


Integrin-Directed Modulation of Macrophage Response to Biomaterials

T. Zaveri, J. Lewis, N. Dolgova, M. Clare-Salzler, B. Keselowsky;

Univ. of Florida, Gainesville, FL.


Extracellular Matrix Proteins Mediate Osteogenic Differentiation of Human Mesenchymal Stem Cells on Phosphate Functionalized Gels Through Integrin Mediated Focal Adhesion Kinase Signaling

N. R. Gandavarapu;

Univ. of Colorado, Boulder, Boulder, CO.


Adsorption Does Not Enhance Exposure of the Fibrinogen Gamma Chain Dodecapeptide

D. L. Elbert, V. Ovod, M. Flake, R. K. Bateman;

Washington Univ., St. Louis, MO.


Broad Application of a Heptaglutamate Domain to Functionalize Hydroxyapatite-Containing Biomaterials

B. K. Culpepper, A. A. Sawyer, S. L. Bellis;

Univ. of Alabama at Birmingham, Birmingham, AL.


von Willebrand Function and Structure Is Different When Adsorbed to Different Synthetic Materials

E. Hillenmeyer, R. Penkala, W. Thomas, D. G. Castner;

Univ. of Washington, Seattle, WA.

Scaffolds for Cardiovascular and Musculosketetal Organ Regeneration


On-Demand Retrieval and Evaluation of MSCs Encapsulated in Enzymatically-Degradable PEG-Based Hydrogels

P. J. Yang, J. S. Temenoff;

Georgia Inst. of Technology, Atlanta, GA.


Relative Influence of Collagen Concentration Versus Substrate Modulus on MSC Fate Decisions

S. Becerra-Bayona, D. Munoz-Pinto, M. S. Hahn;

Texas A&M Univ., College Station, TX.


Evaluation of Multilayer Vascular Grafts Based on Collagen-Mimetic Hydrogels

M. Browning, E. Cosgriff-Hernandez, M. Hahn, D. Dempsey, V. Guiza, B. Russell, M. Hook, F. Clubb, M. Miller, T. Fossum;

Texas A&M Univ., College Station, TX.


Integration of Multiple Cell-Matrix Interactions into Alginate Scaffolds for Cardiac Tissue Regeneration

Y. Sapir, O. Kryukov, S. Cohen;

Ben-Gurion Univ. of the Negev, Beer Sheva, ISRAEL.


Fabrication of TiO2 Nano-Fiber Meshes by Electrospinning and Evaluation of Their Osteoblast Differentiation Potential

R. A. Gittens1, X. Wang2, R. Song1, Z. Schwartz1, H. Chen2, B. D. Boyan1;

1Georgia Inst. of Technology, Atlanta, GA, 2Peking Univ., Beijing, CHINA.


Long-Term In Vitro Cytocompatibility of Hydrogel Nanocomposites as Injectable Bone Substitutes

L. Zhang1, H. Fenniri2, T. J. Webster3;

1The George Washington Univ., Washington, DC, 2Univ. of Alberta, Edmonton, AB, CANADA, 3Brown Univ., Providence, RI.


Efficient Re-differentiation of De-differentiated Chondrocytes in Heparin-Based Hydrogel: In-vitro and In-vivo Study

M. Kim;

Gwangju Inst. of Sci. and Technology, Gwangju, KOREA, REPUBLIC OF.


Engineered Matrix Mimetics Support Assembly of Two Distinct Forms of Fibronectin Matrix

D. C. Roy, D. C. Hocking;

Univ. of Rochester, Rochester, NY.