Con-current Oral Abstract Presentations Session 5

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Animal Models for Biomaterial and Medical Device Testing

162

Projection Micro-StereoLithography (PmSL) Printed PDMS Substrates to Study Flap Revascularization in an Ischemic Mouse Model

implant design; in vivo; porosity

K. N. Cicotte, University of New Mexico, Albuquerque, NM

P. G. McGuire, Department of Cell Biology and Physiology, Albuquerque, New Mexico

T. R. Howdieshell, University of New Mexico Health Science Center, Albuquerque, New Mexico

E. L. Hedberg-Dirk, University of New Mexico, Albuquerque, New Mexico

163

Post-Surgical Pain Management using Long Lasting Analgesic Release from Sol Gel Powder

animal model; drug delivery/release; in vivo

T. Briggs, University of Pennsylvania, Philadelphia, PA

P. Ducheyne, University of Pennsylvania, Philadelphia, Pennsylvania

J. Garino, Orthopedic Surgery Lankenau Institute for Medical Research, Malvern, Pennsylvania

164

Staphylococcus epidermidis Vaccines against Biomaterial Associated Infections

immune response; in vitro; in vivo

L. Yan, University of Washington, Seattle, WA

165

Towards Understanding the Skin-Percutaneous Implant Integration with the Host Soft Tissue

biomimetic

D. H. Betz, University of Utah, Salt Lake City, UT

T. A. Ford, University of Utah, Salt Lake City, Utah

B. M. Holt, University of Utah, Salt Lake City, Utah

M. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

J. P. Beck, University of Utah, Salt Lake City, Utah

R. D. Bloebaum, University of utah, Salt Lake City, Utah

S. Jeyapalina, University of Utah, Salt Lake City, Utah

166

Evaluation of an Absorbable Gentamicin Eluting Plate Sleeve in an Ovine Fracture Model

absorbable; antimicrobial; in vivo

C. DePaula, DePuy Synthes - Biomaterials, West Chester, PA

167

Animal Models for Biomaterials Screening and Neo-Kidney Augment Prototype Evaluation in the Kidney

animal model; regenerative medicine

R. Payne, Tengion, Inc., Winston-Salem, NC

T. Knight, Tengion, Inc., Winston-Salem, North Carolina

J. Basu, Tengion, Inc., Winston-Salem, North Carolina

E. Rivera, Tengion, Inc, Winston-Salem, North Carolina

K. Mihalko, Carolinas Medical Center, Charlotte, North Carolina

N. Robbins, Tengion Inc., Winston-Salem, North Carolina

D. McCoy, Tengion Inc., Winston-Salem, North Carolina

C. Halberstadt, Tengion, Inc, Winston-Salem, North Carolina

D. Jain, Tengion Inc., Winston-Salem, North Carolina

Biomaterials Design and Tissue Engineering via Synthetic Biology

169

Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Immune Cells

cell therapy

W. W. Wong, Boston University, Boston, MA

170

Development of Synthetic Platelets for Hemostatic Applications

biomimetic; coagulation; fibrin

A. C. Brown, Georgia Institute of Technology, Atlanta, GA

S. Stabenfeldt, Arizona State University, Tempe, Arizona

B. Ahn, Georgia Institute of Technology and Children’s Healthcare of Atlanta / Emory University School of Medicine, Atlanta, Georgia

R. Hannan, Georgia Institute of Technology, Atlanta, Georgia

K. Dhada, Georgia Institute of Technology, Atlanta, Georgia

W. Lam, Georgia Institute of Technology and Children’s Healthcare of Atlanta / Emory University School of Medicine, Atlanta, Georgia

A. Lyon, Georgia Institute of Technology, Atlanta, Georgia

T. Barker, Georgia Institute of Technology and Emory University, Atlanta, Georgia

171

Synthetic Biology-inspired Biohybrid Materials for Tissue Engineering and Inducible Drug Delivery

drug delivery/release; tissue engineering

W. Weber, University of Freiburg, Freiburg, Germany

172

Characterization of Modular Resilin-based Biomaterials with Tunable Mechanical Properties for Cartilage Engineering

articular cartilage; hydrogel; tissue engineering

J. C. Liu, Purdue University, West Lafayette, IN

J. C. Liu, Purdue University, West Lafayette, Indiana

R. Su, Purdue University, West lafayette, Indiana

173

Synthesis of thermo-responsive, protein reactive copolymer for cartilage tissue engineering

cartilage; polymerization; tissue engineering

A. Fathi, Jr., The University of Sydney, Sydney, Australia

174

Development of a novel microfabricated cell-laden bioelastomer

bioactive material

N. Annabi, Harvard Medical School, Cambridge, MA

M. Afshar, Harvard medical School, Cambridge, Massachusetts

K. Tsang, Harvard Medical School, Cambridge, Massachusetts

S. Mithieux, University of Sydney, Sydney, Australia

M. Nikkhah, Harvard Medical School, Cambridge, Massachusetts

A. S. Weiss, University of Sydney, Sydney, Australia

A. Khademhosseini, Harvard Medical School, Cambridge, Massachusetts

Dental / Craniofacial Materials

175

Design and Optimization of a Cell-Instructive Hydrogel for Dental Pulp Tissue Engineering

dental/craniofacial material; fibrinogen; hydrogel

S. Prateepchinda, Columbia University, New York, NY

H. H. Lu, Columbia University, New York, New York

G. B. Hasselgren, Columbia University, New York, New York

D. Seliktar, Technion – Israel Institute of Technology, Haifa, Israel

176

Bone Regeneration using Bone Morphogenetic Protein-2 Loaded Tyrosine Polycarbonate Scaffolds

bone ingrowth; craniofacial; regenerative medicine

T. Guda, University of Texas at San Antonio, San Antonio, TX

P. Brown-Baer, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

T. Silliman, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

A. Darr, Rutgers, The State University of New Jersey, Piscataway, New Jersey

J. Kohn, Rutgers, The State University of New Jersey, Piscataway, New Jersey

177

In Vitro Evaluation of Inkjet 3D-Printed (3DP) Fe-Mn Biodegradable Metallic Scaffolds

absorbable; metal (alloys); scaffolds

D. Chou, University of Pittsburgh, Pittsburgh, PA

D. Hong, University of Pittsburgh, Pittsburgh, Pennsylvania

H. A. Kuhn, University of Pittsburgh, Pittsburgh, Pennsylvania

P. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

178

Effect of Nanofiber Alignment on Human Periodontal Ligament Fibroblast Response

craniofacial; scaffolds; tissue engineering

N. M. Lee, Columbia University, New York, NY

S. Kuznetsov, Columbia University Dental School, New York, New York

S. Eisig, Columbia University Dental School, NY, New York

H. H. Lu, Columbia University, New York, New York

179

A novel air-based non-thermal plasma (NTP) approach for the enhancement of Ti-6Al-4V dental implants

dental/endosteal implant; in vivo; surface modification

L. Witek, Oklahoma State University, Stillwater, OK

N. Tovar, New York University, New York, New York

C. Marin, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, Brazil

E. A. Bonafante, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, Brazil

R. Granato, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, Brazil

M. Suzuki, Tufts University School of Dental Medicine, Boston, Massachusetts

P. G. Coelho, New York University, New York, New York

180

Structure/Property of Model Dentin Adhesive Exposed to Wet Environments

adhesion; dental/craniofacial material; FTIR

P. Spencer, University of Kansa, Lawrence, KS

Q. Ye, University of Kansas, Lawrence, Kansas

R. Parthasarathy, University of Kansas, Lawrence, Kansas

V. Singh, University of Kansas, Lawrence, Kansas

A. Misra, University of Kansas, Lawrence, Kansas

J. S. Laurence, University of Kansas, Lawrence, Kansas

181

Photo-polymerization Kinetics of Hydrophilic-rich Phase Mimic in Dentin Adhesive

dental/craniofacial material; hydrophilic; polymerization

Q. Ye, University of Kansas, Lawrence, KS

F. Abedin, University of Kansas, Lawrence, Kansas

P. Spencer, University of Kansas, Lawrence, Kansas

R. Parthasarathy, University of Kansas, Lawrence, Kansas

A. Misra, University of Kansas, Lawrence, Kansas

J. S. Laurence, University of Kansas, Lawrence, Kansas

182

Combination Use of Autologous Periodontal Ligament-derived Cell Sheets and Beta-tricalcium Phosphate Granules in Periodontal Defects in Humans

cell therapy; clinical; regenerative medicine

T. Iwata, Tokyo Women’s Medical University, Tokyo, Japan

Orthopaedic Biomaterials2

183

Non-Degradable Porous Poly(Vinyl Alcohol) Hydrogels for Cartilage Tissue Engineering

cartilage; hydrogel

H. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MA

D. Bichara, Massachusetts General Hospital, Boston, Massachusetts

D. Ling, Massachusetts General Hospital, Boston, Massachusetts

C. Gupta, Massachusetts General Hospital, Boston, Massachusetts

M. Randolph, Massachusetts General Hospital, Boston, Massachusetts

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

184

The Influence of Cathodic Polarization and Simulated Inflammation on Titanium Alloy Electrochemistry

corrosion; orthopedic; titanium (alloys)

E. K. Brooks, University at Buffalo, Buffalo, NY

M. Ehrensberger, University at Buffalo, Buffalo, New York

M. Tobias, University at Buffalo, Buffalo, New York

185

Development of biodegradable ZK40, WX11, and WX41: Novel Mg based alloys for orthopedic applications

biodegradation; corrosion; metal (alloys)

D. Hong, University of Pittsburgh, Pittsburgh, PA

D. Chou, University of Pittsburgh, Pittsburgh, Pennsylvania

P. Saha, University of Pittsburgh, Pittsburgh, Pennsylvania

O. Velikokhatnyi, University of Pittsburgh, Pittsburgh, Pennsylvania

P. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

186

The Effect of Micro-textured CoCrMo-carbide Surfaces on the Attachment and Viability of Osteoblast-like MG63

biocompatibility/hard tissue; cobalt-chromium (alloys); surface modification

S. J. L. Sullivan, University of Maryland, Baltimore County, Baltimore, MD

A. Au, Nutramax Laboratories, Inc., Edgewood, Maryland

M. Grzanna, Nutramax Laboratories, Inc., Edgewood, Maryland

T. Pham, University of Maryland, Baltimore County, Baltimore, Maryland

C. Frondoza, Nutramax Laboratories, Inc., Edgewood, Maryland

L. Topoleski, University of Maryland, Baltimore County, Baltimore, Maryland

187

The Effect of Processing Time, Temperature, and Methane Concentration on Micro-textured  Ti6Al4V-carbide Surface Roughness Parameters

orthopedic; surface modification; titanium (alloys)

S. J. L. Sullivan, University of Maryland, Baltimore County, Baltimore, MD

L. Topoleski, University of Maryland, Baltimore County, Baltimore, Maryland

188

Reduced UHMWPE Wear Using Magnesia-Stabilized Zirconia Femoral Components in High Kinematics/High Load Knee Simulator Tests

knee prosthesis; wear; zirconia

M. E. Roy, Missouri Bone & Joint Research Foundation, St. Louis, MO

L. A. Whiteside, Missouri Bone & Joint Research Foundation; Signal Medical Corp., St. Louis, MO, St. Louis, Missouri

O. F. Noel, IV, Missouri Bone & Joint Research Foundation; Rocky Vista University College of Osteopathic Medicine, Parker, CO, St. Louis, Missouri

189

Vitamin E-Stabilized, Highly Cross-linked UHMWPE Implants: A Short-Term Retrieval Study

orthopedic; polyethylene (UHMWPE)

S. Rowell, Massachusetts General Hospital, Boston, MA

K. Wannomae, Massachusetts General Hospital, Boston, Massachusetts

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

190

Confined and Unconfined Creep: A Comparative Study of Swine Cartilage and PVA Hydrogels

cartilage; hydrogel

D. Ling, Massachusetts General Hospital, Boston, MA

H. Bodugoz-Senturk, Massachusetts General Hospital, Boston, Massachusetts

C. Serrano, Massachusetts General Hospital, Boston, Massachusetts

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Stem Cell-Biomaterial Interactions

192

A Comparative Study of the 2D versus 3D Presentation of Matrix Stiffness on Stem Cell Fate

cell differentiation; cell-material interactions; hydrogel

M. Guvendiren, University of Pennsylvania, Philadelphia, PA

K. Sudhir, University of Pennsylvania, Philadelphia, Pennsylvania

J. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

193

Surface Properties Modulate Integrins, Pluripotent Markers, and Morphogens in Embryonic and Adult Stem Cells

cell-material interactions; stem/progenitor cells; surface modification

R. Olivares-Navarrete, Georgia Institute of Technology, Atlanta, GA

C. A. Cundiff, Georgia Institute of Technology, Atlanta, Georgia

S. L. Hyzy, Georgia Institute of Technology, Atlanta, Georgia

M. T. Cook, Georgia Institute of Technology, Atlanta, Georgia

S. L. Stice, University of Georgia, Athens, Georgia

Z. Schwartz, Georgia Institute of Technology, Atlanta, Georgia

T. McDevitt, Georgia Institute of Technology, Atlanta, Georgia

B. D. Boyan, Georgia Institute of Technology, Atlanta, Georgia

194

Effect of Nanofiber Mineral Content on Human Mesenchymal Stem Cell Osteogenesis

cell-material interactions; osteogenesis; stem/progenitor cells

S. D. Subramony, Columbia University, New York, NY

D. Qu, Columbia University, New York, New York

A. Su, Columbia University, New York, New York

J. P. Heisler, Columbia University, New York, New York

H. H. Lu, Columbia University, New York, New York

195

Comparative Evaluation of Hydrogels As a 3D Angiogenic Matrix for Adipose-Derived Stem Cells

hydrogel; stem/progenitor cells; tissue engineering

E. Chung, The University of Texas at Austin, Austin, TX

J. A. Rytlewski, The University of Texas at Austin, Austin, Texas

A. G. Merchant, The University of Texas at Austin, Austin, Texas

E. W. Lewis, The University of Texas at Austin, Austin, Texas

L. J. Suggs, The University of Texas at Austin, Austin, Texas

196

Direct reprograming of mouse fibroblasts to cardiomyocytes using Yamanaka factors on engineered hydrogels

stem/progenitor cells

D. L. Elbert, Washington University in St. Louis, St. Louis, MO

A. Smith, Washington University in St. Louis, St. Louis, Missouri

P. K. Nguyen, Washington University in St. Louis, St. Louis, Missouri

I. Efimov, Washington University in St. Louis, St. Louis, Missouri

197

Protein-based Biomaterials Accelerate Osteogenic Differentiation

bioactive material; cell differentiation; cell-material interactions

Y. Kim, Purdue University, West Lafayette, IN

J. Liu, Purdue University, West Lafayette, Indiana

Surface Modification Strategies for Antimicrobial Medical Devices

198

A Surface Modification Platform on Eluting Medical Devices

bacterial adherence; cardiovascular; orthopedic

C. Loose, Semprus BioSciences, Cambridge, MA

H. Wang, Semprus BioSciences, Cambridge, Massachusetts

R. Smith, Semprus BioSciences, Cambridge, Massachusetts

G. Brotske, Semprus BioSciences, Cambridge, Massachusetts

A. Cook, Semprus BioSciences, Cambridge, Massachusetts

Z. Zhang, Semprus BioSciences, Cambridge, Massachusetts

199

Local Delivery of D-Amino Acids Reduces Bacterial Burden in Contaminated Rat Segmental Defects

animal model; infection; polyurethane(s)

E. M. Prieto, Vanderbilt University, Nashville, TN

C. J. Sanchez, Jr., United States Army Institute of Surgical Research, Fort Sam Houston, Texas

C. A. Kruger, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

K. J. Zienkiewicz, Vanderbilt University, Nashville, Tennessee

D. R. Romano, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

K. S. Askers, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

S. K. Hardy, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

R. L. Woodburry, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

S. A. Guelcher, Vanderbilt University, Nashville, Tennessee

J. C. Wenke, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

200

Proximity and Cell Density Effects on the Killing Ability of Mg and MgTi Microparticles In-Vitro

cell culture; cell-material interactions; cytotoxicity

J. Kim, Syracuse University, Syracuse, NY

J. L. Gilbert, Syracuse University, Syracuse, New York

201

Sol-gel silica controlled release thin film for inhibition of methicillin resistant staphylococcus aureus

antimicrobial; bacterial adherence; controlled release

S. Bhattacharyya, University of Pennsylvania, Philadelphia, PA

202

Nano-BaSO4 as a Novel Agent to Yield Antimicrobial Thermoplastics for Medical Tubing

antimicrobial

G. E. Aninwene, II, Northeastern University, East Providence, RI

D. Stout, Brown University, Providence, Rhode Island

Z. Yan, Brown University, Providence, Rhode Island

T. J. Webster, Northeastern University, Boston, Massachusetts

B. C. LaBrec, Foster Biomedical Polymers and Compounds, Putnam, Connecticut

203

Silicone Based Nanocomposite for Treatment of Hydrocephalus

antimicrobial

D. MISRA, UNIVERSITY OF LOUISIANA AT LAFAYETTE, LAFAYETTE, LAFAYETTE, NY

204

Long-term stability and effectiveness of antimicrobial coatings incorporating PSP-derived peptides

antimicrobial; surface modification; titanium (alloys)

X. Chen, University of Minnesota, Minneapolis, MN

H. Hirt, University of Minnesota, Minneapolis, Minnesota

K. V. Holmberg, University of Minnesota, Minneapolis, Minnesota

S. Gorr, University of Minnesota, Minneapolis, Minnesota

C. Aparicio, University of Minnesota, Minneapolis, Minnesota

205

PCL (Col)/PVA (HA) coaxial electrospun nanofibers for controllable and sustained drug release

biomimetic; drug delivery/release; nanomaterials/nanophase

W. Song, Wayne state university, Detroit, MI