Con-current Oral Abstract Presentations Session 7

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Engineering Instructive Cues Biomaterials

245

Hydrogels that Mimic Developmentally Relevant N-Cadherin Interactions Enhance MSC Chondrogenesis

articular cartilage; biomimetic; cell-material interactions

L. Bian, the Chinese University of Hong Kong, Shatin, Hong Kong

M. Guvendiren, the University of Pennsylvania, Philadelphia, Pennsylvania

R. Mauck, the University of Pennsylvania, Philadelphia, Pennsylvania

J. A. Burdick, the University of Pennsylvania, Philadelphia, Pennsylvania

246

Multi-Compartment Collagen-Glycosaminoglycan Scaffolds for Engineering the Tendon-Bone Junction

cell-material interactions; scaffolds; tendon prosthesis

S. R. Caliari, University of Illinois at Urbana-Champaign, Urbana, IL

247

Coil-tagging of Vascular Endothelial Growth Factor for Oriented and Tunable Biomaterials Functionalization

endothelial cells; growth factor; immobilization

F. Murschel, Ecole Polytechnique de Montreal, Montreal, QC, Canada

B. Liberelle, Ecole Polytechnique de Montreal, Montreal, Québec, Canada

G. St-Laurent, Biotechnology Research Institute, Montreal, Québec, Canada

M. Jolicoeur, Ecole Polytechnique de Montreal, Montreal, Québec, Canada

Y. Durocher, Biotechnology Research Institute, Montreal, Québec, Canada

R. S. Hodges, University of Colorado, School of Medicine, Aurora, Colorado

G. De Crescenzo, Ecole Polytechnique de Montreal, Montreal, Québec, Canada

248

Modulation of Endothelial Cell Response Through Surface Patterning of VEGF

angiogenesis/neovascularization; nanomodified surfaces

A. S. C. Soon, University of California, Los Angeles, Los Angeles, CA

T. Segura, University of California, Los Angeles, Los Angeles, California

249

Designer growth factor gradients produced by microsphere-assembled scaffolds

sustained release

D. L. Elbert, Washington University in St. Louis, St. Louis, MO

J. L. Roam, Washington University in St. Louis, St. Louis, Missouri

P. K. Nguyen, Washington University in St. Louis, St. Louis, Missouri

250

Manipulation of Protein Sequence and Functionalization to Enhance Cell Interactions with Bioactive Hydrogels

bioactive material; cell-material interactions; hydrogel

M. Browning, Texas A&M University, College Station, TX

B. Russell, Texas A&M Health Science Center, Houston, Texas

J. Rivera, Texas A&M Health Science Center, Houston, Texas

P. T. Luong, Texas A&M University, College Station, Texas

M. Hook, Texas A&M Health Science Center, Houston, Texas

E. Cosgriff-Hernandez, Texas A&M University, College Station, Texas

251

Engineering functional microparticles to fabricate instructive cell microenvironments

cell-material interactions; growth factor; microstructure

C. A. Custódio, 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, Portugal

V. E. Santo, 3B’s Research Group- Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, Portugal

M. M. E. Gomes, 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, Portugal

R. L. Reis, 3B's Research Group- Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, Portugal

J. F. Mano, 3B´s Research Group-Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas- Guimarães, Portugal

252

Biomimetic microenvironments for controlling morphogenesis of human pancreatic ductal epithelial cells

biomimetic; epithelial cells; hydrogel

A. Raza, Indiana-University Purdue-University Indianapolis, Indianapolis, IN

Nanostructured Biomaterials and Porous Scaffolds

254

Synthetic Matrix Vesicles Modulate Mineralization Response of Human Osteoblast-like Cells

bone; lipid; mineralization

P. J. Chuang, Columbia University, New York, NY

T. O. Akinade, Columbia University, New York, New York

L. C. Kam, Columbia University, New York, New York

H. H. Lu, Columbia University, New York, New York

255

A bio-inspired hybrid nanosack for the delivery of pancreatic islets and FGF-2 to improve islet engraftment at the omentum site

diabetes; nanomedicine

H. Jun, University of Alabama at Birmingham, Birmingham, AL

P. Hwang, University of Alabama at Birmingham, Birmingham, Alabama

D. Lim, University of Alabama at Birmingham, Birmingham,, Alabama

S. Gilbert, University of Alabama at Birmingham, Birmingham,, Alabama

W. Cui, University of Alabama at Birmingham, Birmingham, Alabama

J. Corbett, Medical College of Wisconsin, Milwaukee, Wisconsin

256

Design of Short Synthetic β-sheet Forming Peptide Amphiphiles for Antimicrobial Applications

antimicrobial; bioactive material; infection

Z. Ong, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

Y. Yang, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

257

Biphasic Scaffolds for Bone Repair: Nanofiber-Permeated Pore Network for Enhanced Cell Population

phase separated polymer; scaffolds; tissue engineering

C. S. Nelson, University of Connecticut Health Center, Farmington, CT

Y. Khan, University of Connecticut, Farmington, Connecticut

C. T. Laurencin, University Of Connecticut Health Center, Farmington, Connecticut

258

Polyethylene glycol-based Protein Nanocapsules for Functional Delivery of a Differentiation Transcription Factor

degradation; drug delivery/release; nanotechnology

A. Biswas, University of California at Los Angeles, Los Angeles, CA

Y. Liu, University of California at Los Angeles, Los Angeles, California

G. Fan, University of California at Los Angeles, Los Angeles, California

Y. Tang, University of California at Los Angeles, Los Angeles, California

259

Precisely integrating multiple different protein ligands into supramolecular assemblies

biomolecular engineering; hydrogel; nanomaterials/nanophase

G. A. Hudalla, University of Chicago, Chicago, IL

T. Sun, University of Chicago, Chicago, Illinois

J. H. Collier, University of Chicago, Chicago, Illinois

Orthopaedic Polymers

260

Thermoluminescence in UV- and X-Irradiated PEEK

total joint replacement

D. Adhikari, University of Memphis, Memphis, TN

T. Riahinasab, University of Memphis, Memphis, Tennessee

B. Walters, University of Memphis, Memphis, Tennessee

R. Gnawali, University of Memphis, Memphis, Tennessee

M. S. Jahan, University of Memphis, Memphis, Tennessee

261

Production and Characterization of Melt-Spun PEEK Fibers for Biomedical Applications

orthopedic

E. S. Ouellette, Syracuse University, Syracuse, NY

J. L. Gilbert, Syracuse University, Syracuse, New York

262

Injectable Lubricants for Prosthetic Joints

arthroplasty; joint replacement; polyethylene (UHMWPE)

S. Lee, Technical University of Denmark, Kgs. Lyngby, Denmark

263

Mechanical and biological analysis of compression molded polyetheretherketone-titanium (PEEK-Ti) composites

composite/hard tissue; PEEK; spinal implant

H. Park, Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea

H. Jung, Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea

S. Kim, Seoul National Univ., Seoul, Republic of Korea

M. Kang, Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea

H. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea

Y. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia

264

Polymerized Biodegradable Cement to Replace Poly(Methyl Methacrylate) in Vertebral Compression Fracture Augmentation – a Biomechanical Evaluation

biomechanics; bioresorbable; bone cement (= PMMA, acrylic)

B. M. Schlossberg, Pioneer Surgical, Woburn, MA

265

Optimized Wear Resistance and Toughness of Vitamin E blended, High Temperature Melted and Radiation Cross-linked UHMWPE

orthopedic; polyethylene (UHMWPE)

B. Doshi, Massachusetts General Hospital, Boston, MA

E. Oral, Massachusetts General Hospital, Boston, Massachusetts

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

266

Vitamin E Does Not Elute Out of Vitamin E-Grafted Ultra High Molecular Weight Polyethylene

biomaterials availability

M. Guo, Zimmer Inc, Warsaw, IN

A. Rufner, Zimmer Inc, warsaw, Indiana

D. Pletcher, Zimmer Inc, Warsaw, Indiana

O. Popoola, Zimmer Inc, Warsaw, Indiana

D. Yakimicki, Zimmer Inc, Warsaw, Indiana

J. Rufner, Zimmer Inc., Warsaw, Indiana

267

Oxidative Analysis of Retrieved Moderately Cross-linked UHMWPE Acetabular Bearings After 10 Years In Vivo

orthopedic; polyethylene (UHMWPE)

C. Reyes, Massachusetts General Hospital, Boston, MA

S. Rowell, Massachusetts General Hospital, Boston, Massachusetts

C. A. Engh, Jr., AORI, Alexandria, Virginia

R. Hopper, AORI, Alexandria, Virginia

O. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Physical Parameters in the Design of Drug Delivery Systems

268

Geometry Matters: Cellular Uptake of Nanoscale Drug Carriers is Uniquely Dependent on Particle Size and Shape

nanomaterials/nanophase

R. Agarwal, University of Texas at Austin, Austin, TX

V. Singh, University of Texas at Austin, Austin, Texas

P. Jurney, University of Texas at Austin, Austin, Texas

L. Shi, University of Texas at Austin, Austin, Texas

S. Sreenivasan, University of Texas at Austin, Austin, Texas

K. Roy, University of Texas at Austin, Austin, Texas

269

Mathematical Modeling of Bi-phasic Mixed Particle Drug Release from Nanoparticles

degradation; drug delivery/release; nanomedicine

S. S. Hossain, The University of Texas at Austin, Austin, TX

S. Hossainy, Abbott Vascular, Santa Clara, California

D. Davalian, Abbott Vascular, Santa Clara, California

270

How Different Drugs Affect the Properties, Degradation, and Release Profiles of Drug Delivery Films

degradation; drug delivery/release; mechanical properties

C. L. Rabek, University of Kentucky, Lexington, KY

T. D. Dziubla, University of Kentucky, Lexington, Kentucky

D. A. Puleo, University of Kentucky, Lexington, Kentucky

271

Injectable Hydrogels with Controlled Release of Covalently Incorporated Dexamethasone

controlled release; hydrogel; inflammation

D. Bezuidenhout, University of Cape Town, Cape Town, South Africa

N. H. Davies, University of Cape Town, Cape Town, South Africa

A. Oosthuysen, University of Cape Town, Cape Town, South Africa

P. Zilla, University of Cape Town, Cape Town, South Africa

272

Food-Associated Stimuli Enhance Barrier Properties of Mucus

drug delivery/release

H. Yildiz, Northeastern University, Boston, MA

R. L. Carrier, Northeastern University, Boston, Massachusetts

273

Effect of Processing Temperature on the Morphology and Drug-Release Characteristics of Elastin-Like Polypeptide - Collagen Composite Scaffolds

controlled release; drug delivery/release; in vitro

A. Janorkar, University of Mississippi Medical Center, Jackson, MS

N. Patel, University of Mississippi Medical Center, Jackson, Mississippi

274

The physical properties of particles dominate cellular uptake and subsequent influences on cell functions

cell-material interactions; nanomedicine; rigidity

Z. Mao, Zhejiang University, China, Hangzhou, China

275

Effect of Temperature and Size on Release of Calcein from eLiposomes

controlled release; drug delivery/release; nanotechnology

M. Javadi, Brigham Young University, Provo, UT

Surface Modification of Biomaterials for Local Therapy and Diagnostics

276

Multifunctional Drug-Delivery Nanoparticles for Elastic Matrix Stabilization and Repair in Aortic Aneurysms

drug delivery/release; extracellular matrix; nanomedicine

B. Sivaraman, Cleveland Clinic, Cleveland, OH

A. Ramamurthi, Cleveland Clinic, Cleveland, Ohio

277

Magnetic Barcode Assay for Genetic Detection of Pathogens

nanotechnology; surface modification

M. Liong, Massachusetts General Hospital-Harvard Medical School, Charlestown, MA

278

Conducting Polymer Microcavities for Controlled Release of Antineoplastic Agents to Brain Tumors

controlled release; drug delivery/release

P. Fattahi, Pennsylvania State University, State College, PA

M. R. Abidian, Pennsylvania State University, University Park, Pennsylvania

279

Co-Delivery of Paclitaxel and Nitric Oxide from Abluminal and Luminal Surfaces of a Coronary Stent

drug delivery/release; stents; surface characterization

A. Gallo, The University of South Dakota, Sioux Falls, SD

280

Development of an in vitro Focal Neuronal Injury Platform With Simultaneous Neural Recording and Conducting Polymer/Graphene Oxide Nanocomposite-mediated Electrochemical Sensing

biosensors/biochips; neurons; regenerative medicine

C. L. Weaver, University of Pittsburgh, Pittsburgh, PA

N. R. Snyder, University of Pittsburgh, Pittsburgh, Pennsylvania

T. Cui, University of Pittsburgh, Pittsburgh, Pennsylvania

281

Bio-Inspired Assembly for Surface Localization of Gadolinium to Improve Relaxivity of an MRI Contrast-Enhancing Liposome

adsorption; nanomedicine; surface modification

C. E. Smith, University of Illinois at Urbana-Champaign, Urbana, IL

H. Kong, University of Illinois at Urbana-Champaign, Urbana, Illinois

282

CDK Inhibitor PD 0332991 Selectively Inhibits Lung Adenocarcinoma Cells Without Sacrificing Matrix Embedded Endothelial Cells Regulatory Effect on Tumor Proliferation

cell-cell interactions; drug delivery/release; implant design

G. L. A. Cunha, Massachusetts Institute of Technology, Cambridge, MA

A. Freiman, Massachusetts Institute of Technology, Cambridge, Massachusetts

L. Indolfi, Massachusetts Institute of Technology, Cambridge, Massachusetts

N. Artzi, Massachusetts Institute of Technology, Cambridge, Massachusetts

J. L. Dreyfuss, Universidade Federal de São Paulo, São Paulo, Brazil

E. R. Edelman, Massachusetts Institute of Technology, Cambridge, Massachusetts

283

Use of Nanoparticles for Improving Enzyme Stability to Prolong Biosensor Functionality

biosensors/biochips; diabetes; nanomodified surfaces

G. Zhang, Clemson University, Clemson, SC

Wound Dressings That Do More Than Covering the Wounds

285

Effectively Inducing and Monitoring Adipose-derived Stem Cells-mediated Tissue Regeneration using a PEGylated Fibrin and Gold Nanoparticles

fibrin; stem/progenitor cells; wound healing

E. Chung, The University of Texas at Austin, Austin, TX

R. S. Stowers, The University of Texas at Austin, Austin, Texas

S. Y. Nam, The University of Texas at Austin, Austin, Texas

M. A. Samano, The University of Texas at Austin, Austin, Texas

L. M. Ricles, The University of Texas at Austin, Austin, Texas

S. Y. Emelianov, The University of Texas at Austin, Austin, Texas

L. J. Suggs, The University of Texas at Austin, Austin, Texas

286

Accelerated Re-epithelialization of Skin Wounds Using Epidermal Growth Factor Coacervate

controlled release; growth factor; wound healing

N. Johnson, University of Pittsburgh, Pittsburgh, PA

Y. Wang, University of Pittsburgh, Pittsburgh, Pennsylvania

287

Multilayer films addressing bleeding and infection

coagulation; drug delivery/release; infection

B. B. Hsu, Massachusetts Institute of Technology, Cambridge, MA

P. T. Hammond, Massachusetts Institute of Technology, Cambridge, Massachusetts

288

Electrospun Ultralow-fouling Poly(Sulfobetaine Methacrylate) for Nonadherent, Superabsorbent, Antimicrobial, and Reusable Wound Dressings

antimicrobial; fiber; wound dressings

Q. Liu, University of Akron, Akron, OH

R. Lalani, University of Akron, Akron, Ohio

D. Kontoveros, University of Akron, Akron, Ohio

L. Liu, University of Akron, Akron, Ohio

289

Disease State Affects Tissue Microenvironment and Material Performance

biocompatibility/soft tissue; collagen; inflammation

N. Oliva, MIT, Cambridge, MA

290

Quick-Release Medical Tape

adhesion; wound dressings

B. Laulicht, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA

R. Langer, MIT, Cambridge, Massachusetts

J. Karp, Harvard/MIT, Cambridge, Massachusetts