Con-current Oral Abstract Presentations Session 4

Biomaterials for Immunomodulation

117

Biologic Scaffolds Composed of Mammalian Extracellular Matrix Promote a Constructive Macrophage Phenotype

B. M. Sicari, University of Pittsburgh, Pittsburgh, PA

J. L. Dziki, University of Pittsburgh, Pittsburgh, PA

M. Wolf, University of Pittsburgh, Pittsburgh, PA

B. Siu, University of Pittsburgh, Pittsburgh, PA

C. Dearth, University of Pittsburgh, Pittsburgh, PA

N. Turner, University of Pittsburgh, Pittsburgh, PA

S. F. Badylak, University of Pittsburgh, Pittsburgh, PA

118

A microparticle-based vaccine for the amelioration of Type 1 Diabetes

J. S. Lewis, University of Florida, Gainesville, FL

M. Carstens, University of Florida, Gainesville, FL

N. Dolgova, University of Florida, Gainesville, FL

C. Q. Xia, University of Florida, Gainesville, FL

M. Clare-Salzler, University of Florida, Gainesville, FL

B. G. Keselowsky, University of Florida, Gainesville, FL

119

Cytokine-modulating self-assembling peptide materials

C. Mora Solano, University of Chicago, Chicago, IL

R. R. Pompano, University of Chicago, Chicago, IL

J. H. Collier, University of Chicago, Chicago, IL

120

A Biodegradable Antigen-Encapsulating Particle Platform for the Treatment of Immune Dysfunction and the Promotion of Transplant Engraftment

W. Yap, Northwestern University, Chicago, IL

D. P. McCarthy, Northwestern University, Chicago, IL

C. T. Harp, Northwestern University, Chicago, IL

C. B. Smarr, Northwestern University, Chicago, IL

K. A. Hlavaty, Northwestern University, Chicago, IL

W. K. Song, Northwestern University, Chicago, IL

T. J. Kazanova, Northwestern University, Chicago, IL

M. T. Simon, Northwestern University, Chicago, IL

L. Gu, Northwestern University, Chicago, IL

J. Chen, Northwestern University, Chicago, IL

N. Chauhan, Northwestern University, Chicago, IL

A. M. Thomas, Northwestern University, Chicago, IL

S. Ravindran, Northwestern University, Chicago, IL

S. T. Rajan, Northwestern University, Chicago, IL

R. Agarwal, Northwestern University, Chicago, IL

P. N. Scalise, Northwestern University, Chicago, IL

Z. G. Bannon, Northwestern University, Chicago, IL

M. A. Silliman, 0, Northwestern University, Chicago, IL

S. D. Miller, Northwestern University, Chicago, IL

L. D. Shea, Northwestern University, Chicago, IL

121

Assessment of CL075-loaded polymersomes for neonatal vaccination: biodistribution and benchmarking against conventional vaccine formulations

E. Scott, Northwestern University, Evanston, IL

D. Dowling, Boston Children's Hospital and Harvard Medical School, Boston, MA

A. Scheid, Boston Children's Hospital and Harvard Medical School, Boston, MA

I. Bergelson, Boston Children's Hospital and Harvard Medical School, Boston, MA

J. Ninkovik, Boston Children's Hospital and Harvard Medical School, Boston, MA

G. Sanchez-Schmitz, Boston Children's Hospital and Harvard Medical School, Boston, MA

O. Levy, Boston Children's Hospital and Harvard Medical School, Boston, MA

J. Hubbell, EPFL, Lausanne, Switzerland

122

Investigation of pathogen-mimicking particles for delivery of vaccine components in murine tumor models: Comparison of micro vs nano

J. Leleux, Georgia Institute of Technology, Atlanta, GA

P. Pradhan, Georgia Institute of Technology, Atlanta, GA

K. Roy, Georgia Institute of Technology, Atlanta, GA

123

Systems Biology Analysis of Dendritic Cell Responses to Biomaterials

V. Fesenkova, Georgia Institute of Technology, Atlanta, GA

M. Kemp, Georgia Institute of Technology, Atlanta, GA

J. Babensee, Georgia Institute of Technology, Atlanta, GA

124

Polyanhydride nanovaccine and cyclic dinucleotide based formulations stimulate innate immunity and modulate immune response

S. L. Haughney, Iowa State University, Ames, IA

P. Lueth, Iowa State University, Ames, IA

D. Wagner, Iowa State University, Ames, IA

T. W. Dubensky, Aduro Biotech, Inc, Berkeley, CA

B. Bellaire, Iowa State University, Ames, IA

M. J. Wannemuehler, Iowa State University, Ames, IA

B. Narasimhan, Iowa State University, Ames, IA

Ceramics and Composites in Bone Tissue Engineering and Drug Delivery I

125

Hyperelastic Osteogenic Bone Substitute Scaffolds Enabled Through 3D Printing

R. N. Shah, Northwestern University, Chicago, IL

A. E. Jakus, Northwestern University, Chicago, IL

A. L. Rutz, Northwestern University, Chicago, IL

S. Yoo, Northwestern University, Chicago, IL

126

Effect of particulate and putty-like tricalcium phosphate-based bone grafting materials on bone formation, volume stability and osteogenic marker expression after bilateral sinus floor augmentation in humans

C. Knabe, Philipps-University Marburg, Marburg, Germany

E. Kluk, Philipps-University Marburg, Marburg, Germany

M. Bohner, Robert Mathys Foundation, Bettlach, Switzerland

M. Lopez Heredia, Philipps-University Marburg, Marburg, Germany

M. Stiller, Philipps-University Marburg, Marburg, Germany

127

Fabrication and Perfusion Culture of Anatomically Shaped Artificial Bone

D. Du, Harbin Medical University, Brookline, MA

K. Furukawa, University of Tokyo, Bunkyo-Ku, Tokyo, Japan

Y. Anbai, Tokyo Denki University, Tokyo, Japan

T. Asaoka, Tokyo Denki University, Tokyo, Japan

T. Ushida, University of Tokyo, Tokyo, Japan

128

3D Printed Tricalcium Phosphate Scaffolds: MgO and SiO2 Doping for Enhanced Osteogenesis and Angiogenesis

S. Tarafder, Washington State University, Pullman, WA

A. Bandyopadhyay, Washington State University, Pullman, WA

S. Bose, Washington State University, Pullman, WA

129

Biomimetic approaches to engineer bioactive glass-based nanosystems

G. A. M. Luz, Jr., Minho University, Guimarães, Portugal

J. F. Mano, Sr., Minho University, Guimarães, Portugal

130

Amorphous Tri-Magnesium Phosphate (ATMP) as a Novel Bone Scaffolding Material

B. Lee, University of Pittsburgh, Pittsburgh, PA

P. Enick, University of Pittsburgh, Pittsburgh, PA

A. Roy, University of Pittsburgh, Pittsburgh, PA

P. Kumta, University of Pittsburgh, Pittsburgh, PA

131

In Vivo Evaluation of STRUCSURE(TM) CP for Augmentation of Segmental Defect Healing

J. A. Jennings, University of Memphis, Memphis, TN

B. T. Reves, University of Memphis, Memphis, TN

R. Smith, University of Tennessee Health Science Center, Memphis, TN

J. Rose, Smith and Nephew, Memphis, TN

J. D. Bumgardner, University of Memphis, Memphis, TN

W. O. Haggard, University of Memphis, Memphis, TN

132

In vivo Performance of Combinations of Autograft, Demineralized Bone Matrix, and Tricalcium Phosphate in a Rabbit Femoral Defect Model

J. Kim, Hongik University, Sejong, Korea, Republic of

Material/Tissue Interfacial Phenomena: Lessons Learned from Dental/Craniofacial Reconstructions

134

Clinical and Histological Evaluations of Tantalum Porous Dental Implants in a Canine Model

J. Lee, Zimmer Dental Inc./Zimmer Holdings, Carlsbad, CA

S. Battula, Zimmer Dental Inc./Zimmer Holdings, Carlsbad, CA

H. Wen, Zimmer Dental Inc./Zimmer Holdings, Carlsbad, CA

M. Collins, Zimmer Dental Inc./Zimmer Holdings, Carlsbad, CA

135

Development of methodologies to investigate the effect of bacterial biofilm and micro-motion on the corrosion of dental implants

S. Sridhar, University of Texas at Dallas, Richardson, TX

D. C. Rodrigues, University of Texas at Dallas, Richardson, TX

A. Thomas, University of Texas at Dallas, Richardson, TX

A. Adapalli, University of Texas at Dallas, Richardson, TX

K. Palmer, University of Texas at Dallas, Richardson, TX

P. Valderrama, Texas A&M University, Baylor College of Dentistry, Dallas, TX

T. G. Wilson, Jr., Private practice of Periodontics, Dallas, TX

136

Antimicrobial and Mechanical Properties of Bioactive Glass Reinforced Dental Composites

D. Khvostenko, Oregon State University, Corvallis, OR

J. Kruzic, Oregon State University, Corvallis, OR

J. Ferracane, Oregon Health and Science University, Portland, OR

J. Mitchell, Midwestern University, Glendale, AZ

137

Hydrophilic-rich Phase Mimic in Dental Adhesive: Polymerization- and Solvent-Induced Phase Separation

Q. Ye, University of Kansas, Lawrence, KS

F. Abedin, University of Kansas, Lawrence, KS

H. Good, University of Kansas, Lawrence, KS

P. Spencer, University of Kansas, Lawrence, KS

R. Parthasarathy, University of Kansas, Lawrence, KS

C. B. Tamerler, University of Kansas, Lawrence, KS

A. Misra, University of Kansas, Lawrence, KS

J. S. Laurence, University of Kansas, Lawrence, KS

C. L. Berrie, University of Kansas, Lawrence, KS

138

Interfacial Design of Dentin Adhesive with a branched Carboxylic Acid Monomer

P. Spencer, University of Kansas, Lawrence, KS

Q. Ye, University of Kansas, Lawrence, KS

L. Song, University of Kansas, Lawrence, KS

X. Ge, University of Kansas, Lawrence, KS

A. Misra, University of Kansas, Lawrence, KS

C. B. Tamerler, University of Kansas, Lawrence, KS

C. L. Berrie, University of Kansas, Lawrence, KS

J. S. Laurence, University of Kansas, Lawrence, KS

New Frontiers in Polymers and Fibers for Biomedical Applications

140

High Tenacity Polyester Yarns: the New Generation of High Performance Biomaterials

M. W. King, North Carolina State University, Raleigh, NC

C. M. Pastore, Philadelphia University, Philadelphia, PA

R. Torgerson, RxFiber LLC, Windsor, CA

142

Cationic nanofibers as anti-inflammatory scaffolds for chronic wound healing.

H. Juwarker, Duke University, Durham, NC

J. Gamboa, Duke University, Durham, NC

K. Leong, Duke University, Durham, NC

B. Sullenger, Duke University, Durham, NC

143

Proteoglycan Mimetic Graft Copolymers for Growth Factor Stabilization and Delivery

L. W. Place, Colorado State University, Fort Collins, CO

S. Kelly, Colorado State University, Fort Collins, CO

M. J. Kipper, Colorado State University, Fort Collins, CO

144

Smart Hyperthermia Nanofibers with ‘On-Off’ Drug Release

M. Ebara, National Institute for Materials Science, Tsukuba, Japan

Y. Kim, National Institute for Materials Science, Tsukuba, Japan

K. Uto, National Institute for Materials Science, Tsukuba, Japan

T. Aoyagi, National Institute for Materials Science, Tsukuba, Japan

145

Novel Conductive Polymer-based Biomaterials for Pro-Vascularization under Electrical Stimulation

G. M. Xiong, Nanyang Technological University, Singapore, Singapore

C. Choong, Nanyang Technological University, Singapore, Singapore

146

Effect of Melt-blowing Processing on Shape-Memory Polyurethane Microfiber Fabrics

D. L. Safranski, MedShape, Inc, Atlanta, GA

K. Beatty, Georgia Institute of Technology, Atlanta, GA

J. Boothby, Georgia Institute of Technology, Atlanta, GA

K. M. Dupont, MedShape, Inc., Atlanta, GA

C. P. Frick, University of Wyoming, Laramie, WY

J. C. Griffis, MedShape, Inc., Atlanta, GA

147

Elastomeric Electrospun Poly(glycerol sebacate) via a Water-Soluble Carrier Polymer

E. M. Jeffries, University of Pittsburgh, Pittsburgh, PA

R. Allen, University of Pittsburgh, Pittsburgh, PA

S. Nakamura, Kyushu University, Fukuoka, Japan

C. Stowell, University of Pittsburgh, Pittsburgh, PA

Y. Wang, University of Pittsburgh, Pittsburgh, PA

Nucleic Acid Delivery

148

A Layer-by-layer Gene Therapy Approach for Promoting Exogenous and Inhibiting Endogenous Protein Expression

C. J. Bishop, Johns Hopkins University School of Medicine, Baltimore, MD

S. Y. Tzeng, Johns Hopkins University School of Medicine, Baltimore, MD

J. J. Green, Johns Hopkins University School of Medicine, Baltimore, MD

149

Sustained gene delivery from micro-fibrous, elastomeric polymer scaffolds

X. Gu, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

B. Wang, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA

Y. Tang, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA

W. R. Wagner, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

150

Release of Stabilized Diblock Copolymer/Plasmid DNA Polyplexes from Injectable Scaffolds

E. J. Adolph, Vanderbilt University, Nashville, TN

C. E. Nelson, Vanderbilt University, Nashville, TN

C. L. Duvall, Vanderbilt University, Nasvhille, TN

S. A. Guelcher, Vanderbilt University, Nashville, TN

151

Non-viral oral gene delivery for treatment of Hemophilia B.

J. Gamboa, Duke University, Durham, NC

S. Suryaprakash, Duke University, Durham, NC

K. Leong, Duke University, Durham, NC

152

Immunomodulation of Cystic Fibrosis Epithelial Cells via NF-κB Decoy Oligonucleotide Coated Polysaccharide Nanoparticles

P. R. Wardwell, Syracuse University, Syracuse, NY

R. A. Bader, Syracuse University, Syracuse, NY

153

Scalable Synthesis of Functional Polyesters that Enable Effective siRNA Delivery to Cancer Cells

D. J. Siegwart, University of Texas Southwestern Medical Center, Dallas, TX

Y. Yan, University of Texas Southwestern Medical Center, Dallas, TX

J. B. Miller, University of Texas Southwestern Medical Center, Dallas, TX

154

Identifying Effective siRNAs for Polymer-Mediated Combinatorial Delivery to Drug Sensitive and Resistant Breast Cancer Cells

H. Uludag, University of Alberta,

H. M. Aliabadi, University of Alberta,

P. Aliabadi, University of Alberta,

155

In Vivo Gene Delivery and Multimodal Imaging of Multifunctional Degradable Nanoparticles after Delivery to Lung

K. C. L. Black, Washington University School of Medicine, St. Louis, MO

Trends in Surface Modification of Bulk- and Nano-Biomaterials I

156

Hydrogel Coatings for High-Speed Cell Sorting

B. J. Berron, University of Kentucky, Lexington, KY

G. Romero, University of Kentucky, Lexington, KY

J. L. Lilly, University of Kentucky, Lexington, KY

V. Balasubramaniam, University of Colorado-Denver, Aurora, CO

157

Characterization of Mammalian Cell Interactions on Coatings Based on Plant Polyphenols

D. G. Barrett, Northwestern University, Evanston, IL

T. S. Sileika, Northwestern University, Evanston, IL

P. B. Messersmith, Northwestern University, Evanston, IL

158

Quantification of the Charge Density on Surfaces Under Identical Solution Conditions Using Analytical Techniques that Probe Different Regions of the Solid-Liquid Interface

A. A. Thyparambil, Clemson University, Clemson, SC

Y. Wei, Clemson University, Clemson, SC

G. Hickman, Nottingham Trent University, Nottingham, United Kingdom

D. Belton, Nottingham Trent University, Nottingham, United Kingdom

C. C. Perry, Nottingham Trent University, Nottingham, United Kingdom

R. A. Latour, Clemson University, Clemson, SC

159

Single step immobilization of REDV peptide onto a variety of biomaterial substrates by tyrosine oxidation

S. Kakinoki, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan

T. Yamaoka, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka, Japan

160

Surface hydrolysis mediated PEGylation for the passivation of PNIPAAm Nanogels

J. T. Peters, The University of Texas at Austin, Austin, TX

S. Verghese, The University of Texas at Austin, Austin, TX

N. A. Peppas, The University of Texas at Austin, Austin, TX

161

Enhanced Capture of Cancer cells on Aptamer-Modified Topographical Surfaces

X. Liu, Soochow University, Suzhou, China

Y. Wang, Soochow University, Suzhou, China

H. Chen, Soochow University, Suzhou, China

162

Glycosylated polypeptide nanofibers as polyvalent lectin inhibitors with enzymatically-tunable binding specificity

G. Hudalla, University of Florida, Gainesville, FL

Y. Tian, Illinois Institute of Technology, Chicago, IL

J. Collier, University of Chicago, Chicago, IL

163

Tuning Polymeric Micelle Stability with Selective Polyethylene Glycol Density

J. Logie, University of Toronto,

C. K. McLaughlin, University of Toronto,

S. C. Owen, University of Toronto,

M. S. Shoichet, University of Toronto,