Bio-Nanomaterials for Cancer Theranostic Treatment

10:30 a.m. 127. Invited Speaker: Shuming Nie, Eomry University

11:00 a.m. 128. Therapeutic in vivo RNAi-based Nanoparticle Silencing in Lung Tumor-Associated Macrophages, J. Conde*(1), C. Bao(2), Y. Tan(3), D. Cui(2), E. R. Edelman(1), H. S. Azevedo(4), H. J. Byrne(3), F. Tian(3), N. Artzi(1), (1)Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, Cambridge, MA, United States Minor Outlying Islands, (2)Department of Bio-Nano Science and Engineering, National Key Laboratory of Micro/Nano Fabrication Technology, Institute of Micro&Nano Science and Technology, Shanghai, China, (3)Focas Research Institute, Dublin Institute of Technology, Dublin, Ireland, (4)School of Engineering and Materials Science, Queen Mary University, of London, London, United Kingdom

11:15 a.m. 129. Biodegradable Photoluminescent Nanoparticles for Immune Cell-Mediated Melanoma Targeting and Theranostic Drug Delivery, Z. Xie*(1), Y. Su(1), E. Selvi(1), G. B. Kim(2), V. A. Sanabria(1), C. Ma(1), C. Dong(1), J. Yang(1), (1)Penn State University, University Park, PA, (2)Penn State University, Hershey, PA

11:30 a.m. 130. Multiplexed Biomarker Detection using Phase Change Nanoparticles, J. An*, Northeastern University, Boston, MA

11:45 a.m. 131. Azole-functionalized Nanoparticles for Imaging & Drug Delivery, R. J. Cavazos, Jr.*, University of North Texas, Denton, TX

12:00 p.m. 132. Single Cell Array Based Toxicity Assay for Personalized Medicines, Y. Qiao*, Northeastern University, Boston, MA

12:15 p.m. 133. Cancer Specific and Multicolor Bioimaging using Triple-Triplet Annihilation Upconversion Nanocapsules, H. S. Song*(1), O. S. Kwon(2), J. Conde(1), J. Kim(2), N. Artzi(1), (1)Massachusetts Institute of Technology, Cambridge, MA, (2)Yale University, New Haven, CT

Biofabrication and Biomanufacturing in Tissue Engineering and Regenerative Medicine (TERM) 2

10:30 a.m. 120. Invited Speaker: 3-D Organ Printing in Regenerative Medicine, James J. Yoo, Wak Forest School of Medicine

11:00 a.m. 121. Computer Aided Biomanufacturing of Protein Scaffolds with Controlled Macroporosity, A. Islam*, K. Chapin, M. Younesi, O. Akkus, Case Western Reserve University, Cleveland, OH

11:15 a.m. 122. Supramolecular, Guest-Host Hydrogels for 3D Bioprinting of Material and Cellular Structures, C. B. Highley*, C. B. Rodell, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

11:30 a.m. 123. A Multi-Material Bioink Method for 3D Printing Tunable and Cell-Compatible Hydrogels, A. L. Rutz*(1), K. E. Hyland(1), A. E. Jakus(1), W. R. Burghardt(2), R. N. Shah(1), (1)Northwestern University, Chicago, IL, (2)Northwestern University, Evanston, IL

11:45 a.m. 124. Bioprinted Liver Organoid for Toxicology Testing, H. Kang*, S. J. Lee, A. Skardal, I. Mead, M. Devarasetty, T. Shupe, C. Bishop, J. Jackson, S. Soker, J. Yoo, A. Atala, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

12:00 p.m. 125. 3-D Bioprinting of Skeletal Muscle Tissue Constructs for Accelerated Restoration of Muscle Function, J. H. Kim*, Y. Seol, I. K. Ko, H. Kang, H. S. Kim, J. S. Lee, S. J. Lee, A. Atala, J. J. Yoo, WFIRM, winston salem, NC

12:15 p.m. 126. Collagen NanoFiber Coating on Cell Surfaces for Construction of Cell-Density Controlled 3D-Thick Tissues, M. Matsusaki*, C. Liu, M. Akashi, Osaka University, Osaka, Japan

Engineering Cells & Their Microenvironments

10:30 a.m. 134. Scaffold Fiber Diameter and Alignment Co-Regulate Tendon Fibroblast Response, W. Levine, C. Erisken, H. Lu, N. Lee*, Columbia University, NY, NY

10:45 a.m.135. Identifying Localized Shear Forces and Nutrient Gradients in 3D Flow Perfusion MSC Cultures, C. Williams*(1), A. Simmons(1), D. Papavassiliou(1), R. Voronov(2), V. Sikavitsas(1), (1)University of Oklahoma, Norman, OK, (2)New Jersey Institute of Technology, Newark, NJ

11:00 a.m. 136. Poly(dimethyl siloxane)-Containing Nanofiber Meshes as a Platform for Studying Stem Cell Behavior, D. R. Bogdanowicz*, P. J. Chuang, L. C. Kam, H. H. Lu, Columbia University, New York, NY

11:15 a.m. 137. Conducting Polymer Films with Biomolecular Gradients for Cell Adhesion Control, S. Park*, D. Nocera, M. R. Abidian, S. Majd, Pennsylvania State University, University Park, PA

11:30 a.m. 138. Anisotropically Stiff Micropillars as a Unidirectional Cell Entrapment and Alignment Niche for Cardiomyocytes, Y. Alapan*, M. Younesi, O. Akkus, U. Gurkan, Case Western Reserve University, Cleveland, OH

11:45 a.m. 139. Maxwell Stress Field Induced Biological Cell Deformation in an Electric Field Stimulated Medium, R. Krishnamurthy*, V Kumaran, B. Basu, Indian Institute of Science, Bangalore, Bangalore, India

12:00 p.m. 140. PC12 Cell Attachment, Proliferation, and Differentiation on Polymer Spherulites, X. Wu, S. Wang*, The University of Tennessee, Knoxville, Knoxville, TN

12:15 p.m. 141. The Direction of Stretch-Induced Cell and Stress Fiber Orientation Depends on Collagen Matrix Stress, R. Kaunas*, A. Tondon, Texas A&M University, College Station, TX

Local Delivery of Drugs and Growth Factors from Implant Coatings

10:30 a.m. 142. Dextran Sulfate Thin Films: A Novel Drug Delivery Platform for Drug-Eluting Balloon Applications, S. Lamichhane*, G. Mani, The University of South Dakota, Sioux Falls, SD

10:45 a.m. 143. Hydrogel Implant Coatings for Peripheral Nerve Regeneration, D. Bhatnagar, J. Bushman, B. A. Clements, S. Murthy, J. Kohn*, Rutgers University, Piscataway, NJ

11:00 a.m. 144. Porous Dexamethasone-Relasing Coatings Improve the Performance of Implantable Glucose Sensors in Normal and Diabetic Rats, S. G. Vallejo-Heligon*, N. L. Brown, B. Klitzman, W. M. Reichert, Duke University, Durham, NC

11:15 a.m. 145. Engineering Drug-Eluting Coatings to Design Next Generation Devices for Locally Treat Pancreatic Cancer, L. Indolfi*(1), M. Ligorio(2), D. Ting(2), R. Tzafriri(3), C. Ferrone(4), J. Clark(4), R. Langer(5), E. Edelman(5), (1)MIT - MGH Cancer Center, Cambridge, MA, (2)MGH Cancer Center, Boston, MA, (3)CBSET Inc., Lexington, MA, (4)MGH Surgery - Cancer Center, Boston, MA, (5)MIT, Cambridge, MA

11:30 a.m. 146. Local Delivery of Paclitaxel Using Infusion Balloon Catheters, J. Anderson*(1), G. Mani(1), T. Remund(2), P. Kelly(3), L. Danielson(2), M. Nykamp(2), K. Pohlson(2), R. Evans(2), K. Egland(2), M. Clark(2), (1)The University of South Dakota, Sioux Falls, SD, (2)Sanford Research, Sioux Falls, SD, (3)Sanford Vascular Associates, Sioux Falls, SD

11:45 a.m. 147. Surface Modification of Ti with Micro/Nano Multi-Scale Roughness for the Growth Factor Loaded Implant, S. W. Kim*, T. Jang, B. Moon, J. Song, H. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea

12:00 p.m. 148. Photoluminescent Antioxidant Oligomers with Potent UV-Absorbing Properties, J. Yang, R. van Lith, G. A. Ameer*, Northwestern University, Evanston, IL

12:15 p.m. 149. Vancomycin Release From Point-of-Care Phosphatidylcholine Implant Coatings, D. Carpenter*(1), K. Troxel(2), W. Haggard(1), J. A. Jennings(1), (1)University of Memphis, Memphis, TN, (2)Biomet Orthopedics, LLC, Warsaw, IN


10:30 a.m. 150. Cellular Protease-Mediated Programmed Delivery of Anticancer Cytokine and Small-Molecule Drug, W. Sun*, T. Jiang, R. Mo, Z. Gu, Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA, Center for Nanotechnology in Drug Delivery and Division of Molecular, Pharmaceutics Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Raleigh, NC

10:45 a.m. 151. Neural Cell Functionality Modulation and Bacterial Growth Deactivation on Patterned Carbon Substrates, B. Basu, Sr.*(1), S. Jain, Jr.(1), A. Sharma, Sr.(2), (1)Indian Institute of Science, Bangalore, India, (2)Indian Institute of Technology Kanpur, Kanpur, India

11:00 a.m. 152. 3D-Printed Osteo-Electro Hydroxyapatite-Graphene Composites, A. E. Jakus*, R. N. Shah, Northwestern University, Simpson Querrey Institute for BioNanotechnology, Chicago, IL

11:15 a.m. 153. Superparamagnetic Iron Oxide Nanocomposites and Autophagy Response from Macrophage Cells, c. wu, h. Ai, l. Yang, r. Jin*, National Engineering Research Center for Biomaterials, Sichuan University, PR China, chengdu, China

11:30 a.m. 154. Preparation of a Nano-Patterned PDMS Replica for Reducing Catheter Associated Infections, L. Liu*, B. Ercan, L. Sun, T. Webster, Northeastern University, Boston, MA

11:45 a.m. 155. An Anti-Inflammatory Drug Delivery System Based on Chitosan/Poly-Glutamic Acid Nanoparticles to Treat Inflammation and Degeneration of Intervertebral Disc: An Ex Vivo Study, G. Teixeira(1), A. C. L. Pereira(1), H. Wilke(2), C. Neidlinger-Wilke(2), M. A. Barbosa(1), C. Neidlinger-Wilke(2), R. M. Gonalves*(1), (1)Institute of Biomedical Engineering (INEB), Porto, Portugal, (2)Institute of Orthopaedic Research and Biomechanics, Ulm, Germany

12:00 p.m. 156. Visualizing Structure of Bio-Functional Magnetic Nano-Particles with Analytical Electron Microscopy, J. Wang*, L. Wang, A. M. Ferrie, Y. Jin, Corning Incorporated, Corning, NY

12:15 p.m. 157. Increased cell functions using BMP-7 functionalized rosette nanotubes, G. MI*(1), L. Sun(1), A. Alsbaiee(2), U. Hemraz(2), J. CHO(2), H. Fenniri(1), T. Webster(1), (1)Northeastern University, Boston, MA, (2)University of Alberta, Edmonton, Canada

Orthopaedic Biomaterials 2

10:30 a.m. 158. An Analysis of Corrosion Products caused by Fretting/Wear-Accelerated Crevice Corrosion on Retrieved Co-Cr-Mo Implants, M. A. Di Prima*(1), O. Vesnovsky(1), L. T. Topoleski(2), R. Hopper(3), C. A. Engh, Jr.(3), P. Kovacs(4), (1)US Food and Drug Administration, Silver Spring, MD, (2)University of Maryland Baltimore County, Baltimore, MD, (3)Anderson Orthopedic Research Institute, Alexandria, VA, (4)Electrochemistry/Biocompatibility Consultant, Santa Claus, IN

10:45 a.m. 159. Development of Biodegradable Polyurethane-ureas as Gradient Scaffolds for Ligament and Tendon Repair, T. Touchet*(1), A. Kishan(1), M. Detamore(2), E. Cosgriff-Hernandez(1), (1)Texas A&M University, College Station, TX, (2)University of Kansas, Lawrence, KS

11:00 a.m. 160. Effect of Recombinant Fibronectin Fragment Coating on Osseointegration of Stainless Steel Screws in Healthy and Osteoporotic Rats, R. Agarwal*(1), C. Gonzlez-Garca(1), B. Torstrick(1), R. E. Guldberg(1), M. Salmeron-Sanchez(2), A. J. Garcia(1), (1)Georgia Institute of Technology, Atlanta, GA, (2)University of Glasgow, Glasgow, United Kingdom

11:15 a.m. 161. The Novel Use of Acoustic Radiation Force to Mechanically Load Hydrogel-Encapsulated Osteoblasts for Bone Repair, J. Veronick*(1), V. Vyas(2), B. Huey(2), Y. Khan(1), (1)University of Connecticut Health Center, Farmington, CT, (2)University of Connecticut, Storrs, CT

11:30 a.m. 162. Pilot In Vivo Evaluation of a Resorbable, Antibiotic-Eluting Bone Void Filler to Prevent Periprosthetic Joint Infection, K. D. Sinclair*(1), A. E. Brooks(2), Z. Ferrell(3), D. W. Grainger(2), (1)Elute, Inc., Salt Lake City, UT, (2)University of Utah, Salt Lake City, UT, (3)University of Utah, Bountiful, UT

11:45 a.m. 163. A Non-Weight Bearing Model of Osteoporosis for Histomorphometric and Mechanical Evaluation of Bone Repair Using Bone Graft Substitutes, D. J. Hall, T. M. Turner*, S. M. McCarthy, S. Gitelis, R. M. Urban, Rush University Medical Center, Chicago, IL

12:00 p.m. 164. Growth Factor Incorporated Collagen Threads as Suturable Therapeutic for Tendon Repair, M. Younesi*, B. Ozgur Donmez, O. Akkus, Case Western Reserve University, Cleveland, OH

12:15 p.m. 165. Corrosion Behavior of Ti-6Al-4V Orthopaedic Alloy Under Tensile Stress, P. Panigrahi*(1), A. Poursaee(2), M. K. Harman(1), (1)Clemson University, Greenville, SC, (2)Clemson University, Clemson, SC

Panel Discussion: Trauma: The New Frontier in Biomaterials

165. Michael Yaszemski, Mayo Clinic

166. James Ficke, Johns Hopkins University

167. Hassan Tetteh, US Navy, Bureau of Medicine and Surgery

Tissue Engineering

10:30 a.m. 170. Comparison of Tissue Engineered Intestine Produced from Non-woven Polyglycolic Acid, CollaTape Collagen, and Nanofiber Poly (caprolactone) Scaffolds, Y. Liu*(1), T. Rager(1), J. Johnson(2), J. Lannutti(3), J. Enmark(2), T. Nelson(3), G. E. Besner(1), (1)The Research Institute at Nationwide Children's Hospital, Columbus, OH, (2)Nanofiber Solutions, LLC, Columbus, OH, (3)The Ohio State University, Columbus, OH

10:45 a.m. 171. Vibratory Stimulation for Anti-Fibrotic Therapy, S. Bae*(1), J. S. Lee(1), J. L. Barth(2), K. Webb(1), (1)Clemson University, Clemson, SC, (2)Medical University of South Carolina, Charleston, SC

11:00 a.m. 172. Bi-Layer Silk Fibroin Grafts Support Functional Tissue Regeneration in a Rat Model of Onlay Esophagoplasty, K. Algarrahi*(1), D. Franck(1), C. Ghezzi(2), V. Cristafaro(3), X. Yang(1), M. P. Sullivan(3), Y. G. Chung(1), D. L. Kaplan(2), C. R. Estrada, Jr.(1), J. R. Mauney(1), (1)Boston Children's Hospital, Boston, MA, (2)Tufts University, Medford, MA, (3)Veterans Administration Boston Healthcare System, West Roxbury, MA

11:15 a.m. 173. Integrin Activation as a Tool to Modulate Vascular Patterning, S. Li*(1), T. Barker(2), T. Segura(1), (1)University of California, Los Angeles, Los Angeles, CA, (2)Georgia Institute of Technology and Emory University, Atlanta, GA

11:30 a.m. 174. New Method for Evaluation of Nano-Drug Carriers by 3D-Arterial Wall Models for Atherosclerosis Treatment, P. Chetprayoon*(1), M. Matsusaki(1), U. Yokoyama(2), Y. Ishikawa(2), M. Akashi(1), (1)Osaka University, Graduate School of Engineering, Osaka, Japan, (2)Yokohama City University Graduate School of Medicine, Yokohama, Japan

11:45 a.m. 175. Silk-PLA Bio-composite Materials for Medical Applications, X. Hu*, Rowan University, Glassboro, NJ

12:00 p.m. 176. The Effect of Cyclic Loading on the Material Properties of Isolated Arterial Elastin, T. Topoleski*, University of Maryland Baltimore County, Baltimore, MD

12:15 p.m. 177. Swelling and Rheological Characterization of Biodegradable Dextran-based Hydrogels, D. R. Janagam*, G. L. Ndifon, T. L. Lowe, University of Tennessee Health Science Center, Memphis, TN