Biomimetic Materials for Tissue Engineering

1:30 p.m. 178. Construction of iPS-Derived 3D-Cardiac Myoblast Tissues Containing Blood Capillary Network by Cell Accumulation Technique, Y. Amano*(1), A. Nishiguchi(2), M. Matsusaki(2), S. Miyagawa(3), Y. Sawa(3), M. Akashi(2), (1)Department of Applied Chemistry, Suita, Japan, (2)Graduate School of Engineering, Osaka University, Suita, Japan, (3)Graduate School of Medicine, Osaka University, Suita, Japan

1:45 p.m. 179. Highly Transparent Dense Collagen Sheets for Corneal Tissue Engineering Applications, R. Iyer, V. Kishore*, Florida Institute of Technology, Melbourne, FL

2:00 p.m. 180. Microribbon-like Hydrogels with Diverse Biological Cues for Forming 3D Scaffolds: a "Lego-building" approach, F. Yang*, X. Tong, L. Han, S. Lee, Stanford University, Stanford, CA

2:15 p.m. 181. Biomimetic Materials Modulate Specific Growth Factor Signaling In Vitro and In Vivo, D. G. Belair*, M. J. Miller, A. V. Kellner, S. Wang, N. Sheibani, W. L. Murphy, University of Wisconsin-Madison, Madison, WI

2:30 p.m. 182. Bridging the Gap: Assessing an Engineered Biomimetic Periosteum on Bone Allografts for the Reconstruction of Large Segmental Bone Defects in Mice, R. Romero*, L. S. Chubb, J. K. Travers, R. Rose, A. Pennybaker, E. Asbury, N. P. Ehrhart, M. J. Kipper, Colorado State University, Fort Collins, CO

2:45 p.m. 183. Three Dimensional Multiphase Biomimetic Scaffold for Tissue Engineering Muscle-Tendon Junctions, T. He*(1), S. J. Lee(2), J. Chen(1), X. Tang(1), M. W. King(1), (1)North Carolina State University, Raleigh, NC, (2)Wake Forest School of Medicine, Winston-Salem, NC, NC

3:00 p.m. 184. Electrospinning Degradable Hydrogel Nanofibres for Tissue Engineering, H. Sheardown*, T. Hoare, McMaster University, Hamilton, ON, Canada

3:15 p.m. 185. Electrochemically Aligned Collagen-Elastin Fibers for Vascular Tissue Engineering, T. Nguyen, C. A. Bashur, V. Kishore*, Florida Institute of Technology, Melbourne, FL

Cardiovascular Biomaterials 2

1:30 p.m. 186. EPC Capturing Technology for Improving Patency of Small-Diameter (2mm ID) and Long (30 cm Length) Acellular Blood Vessels, T. Yamaoka*(1), S. Somekawa(1), M. Kitai(1), Y. Ohya(2), Y. Kimura(3), T. Fujisato(4), A. Mahara(1), (1)National Cerebral and Cardiovascular Center Research Institute, Suita, Japan, (2)Kansai University, Suita, Japan, (3)Kyoto Institute of Technology, Kyoto, Japan, (4)Osaka Institute of Technology, Osaka, Japan

1:45 p.m. 187. Hemocompatibility of Crosslinked or Thrombomodulin-modified Decellularized Matrix, J. J. Glynn*(1), E. G. Polsin(2), M. T. Hinds(1), (1)Oregon Health & Science University, Portland, OR, (2)University of Portland, Portland, OR

2:00 p.m. 188. Peptide-grafted Hydrogels to Capture Endothelial Progenitor Cells under Shear for Endothelialization, W. J. Seeto*, E. A. Lipke, Auburn University, Auburn University, AL

2:15 p.m. 189. Mechanocompatible Polymer-Extracellular Matrix Composites for Vascular Tissue Engineering, B. Jiang*(1), J. Wertheim(2), G. Ameer(1), (1)Northwestern University, Evanston, IL, (2)Northwestern University, Chicago, IL

2:30 p.m. 190. Catheters Prepared with Nitric Oxide (NO) Releasing Lumen for Improved Hemocompatibility, E. J. Brisbois*, H. Handa, T. C. Major, J. Wu, J. Brownstein, C. Xi, M. E. Meyerhoff, R. H. Bartlett, University of Michigan, Ann Arbor, MI

2:45 p.m. 191. Syndesomes Microencapsulated in Alginate for Revascularization in Peripheral Ischemia, S. Das*(1), G. Singh(1), A. J. Monteforte(1), M. E. Martinez(1), C. S. Wright(2), P. E. Martin(2), A. K. Dunn(1), A. B. Baker(1), (1)University of Texas, Austin, Austin, TX, (2)Glasgow Caledonian University, Glasgow, United Kingdom

3:00 p.m. 192. 3D Structured Biomaterials to Induce Vascularization after Ischemic Cardiovascular Events, F. Munarin*, K. Coulombe, Brown University, Providence, RI

3:15 p.m. 193. Platelet-inspired Biomaterials Engineering for Synthetic Intravenous Hemostat, A. Sen Gupta*(1), C. Modery-Pawlowski(1), C. Kos(1), A. Anselmo(2), S. Mitragotri(2), (1)Case Western Reserve University, Cleveland, OH, (2)University of California Santa Barbara, Santa Barbara, CA

Ceramics and Composites in Bone Tissue Engineering and Drug Delivery

1:30 p.m. 194. Effect of Tricalcium Phosphate-based Paste- and Foam-like Bone Grafting Materials on Bone Regeneration and Osteogenic Marker Expression in vivo, M. Lopez Heredia*(1), D. Barnewitz(2), A. Genzel(2), F. Peters(3), A. Kuhr(1), B. Stang(1), W. Huebner(3), (1)Philipps-University Marburg, Marburg, Germany, (2)Veterinary Research Center, Bad Langensalza, Germany, (3)Curasan AG, Kleinostheim, Germany

1:45 p.m. 195. Fabrication of Porous Carbonate Apatite and Its In Vivo Evaluation, K. Ishikawa*, N. X. T. Tram, K. Tsuru, Kyushu University, Fukuoka, Japan

2:00 p.m. 196. Phage-Derived Bi-Functional Peptides Improve Human BMSC Interactions on Biomimetic Apatite, H. Ramaraju*, D. H. Kohn, University of Michigan, Ann Arbor, MI

2:15 p.m. 197. Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering, S. S. Chen*(1), J. Kohn(2), (1)Rutgers, The State University of New Jersey, Piscataway, NJ, (2)New Jersey Center for Biomaterials, Rutgers-The State University of New Jersey, Piscataway, NJ

2:30 p.m. 198. Anti-cancer and Anti-microbial Selenium Nanoparticle Bone Scaffolds, M. Stolzoff*, T. J. Webster, Northeastern University, Boston, MA

2:45 p.m. 199. Simvastatin-Releasing Calcium Sulfate and Calcium Phosphate Bioceramics, Y. Gu, B. R. Orellana, D. A. Puleo*, University of Kentucky, Lexington, KY

3:00 p.m. 200. Effect of Mannitol Porogen Addition on Magnesium Phosphate Cements, N. J. Ostrowski*, B. Lee, A. Roy, P. Kumta, University of Pittsburgh, Pittsburgh, PA

3:15 p.m. 201. Twinning Induced Enhancement of Fracture Toughness in Ultra-Fine Grained Hydroxyapatite-Calcium Titante Composites, R. Krishnamurthy*(1), P. K. Mallik(2), S. Pramanik(3), S. Suwas(3), K. Balani(2), B. Basu(3), (1)Indian Institute of Science, Bangalore, Indian Institute of Science, Bangalore, India, (2)Indian Institute of Technology, Kanpur, Kanpur, India, (3)Indian Institute of Science, Bangalore, Bangalore, India

Delivery of Nucleic Acids and Other Molecules that Modulate Gene Expression

1:30 p.m. 202. NF-KappaB Decoy Oligodeoxynucleotide Increases Bone Mineral Density in the Murine Femur during Continuous Infusion of Polyethylene Particles, T. Lin*(1), T. Sato(1), J. Pajarinen(1), C. Fan(1), F. Loi(1), R. Zhang(1), Z. Yao(1), K. Egahishira(2), S. Goodman(1), (1)Stanford University, Palo Alto, CA, (2)Kyushu University, Fukuoka, Japan

1:45 p.m. 203. Elucidating Structure-Function Relationships of Poly(beta-amino ester)s for Non-viral Gene Delivery via Principal Component Analysis, C. J. Bishop*(1), B. Abubaker-Sharif(1), T. Guiriba(2), J. J. Green(1), (1)The Johns Hopkins University School of Medicine, Baltimore, MD, (2)The Johns Hopkins University, Baltimore, MD

2:00 p.m. 204. Surface-Associated DNA Presentation for Sustained Gene Delivery with Porous Hyaluronic Acid Hydrogels, N. F. Truong*, T. Segura, UCLA, Los Angeles, CA

2:15 p.m. 205. Porous Silicon Nanoparticle Delivery of Peptide Nucleic Acid Anti-MicroRNA Therapeutics, K. R. Beavers*(1), J. W. Mares(2), S. M. Weiss(2), C. L. Duvall(2), (1)Interdisciplinary Material Science, Nashville, TN, (2)Vanderbilt University, Nashville, TN

2:30 p.m. 206. Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nano-Formulations T. A. Werfel*, M. Miteva, C. Duvall Vanderbilt University, Nashville, TN

2:45 p.m. 207. Conjugation of Palmitic Acid Improves Potency and Longevity of siRNA Delivered via Endosomolytic Polymer Nanoparticles, S. M. Sarett*, K. V. KIlchrist, M. Miteva, C. L. Duvall, Vanderbilt University, Nashville, TN

3:00 p.m. 208. CXCR4-Overexpressing Adipose-Derived Stem Cells Enhanced Brain Tumor Tropism In Vitro, X. Jiang*, C. Wang, F. Yang, Stanford University, Stanford, CA

3:15 p.m. 209. Photocleavable Hydrogels For Light-Triggered siRNA Release, C. T. Huynh*(1), M. K. Nguyen(1), G. Y. Tonga(2), V. M. Rotello(2), E. Alsberg(1), (1)Case Western Reserve University, Cleveland, OH, (2)University of Massachusetts, Amherst, MA

Harnessing Biomaterials to Engineer the Adaptive Response for Immunity or Tolerance

1:30 p.m. 210. Invited Speaker: A Tale of Two T-Cells: Directing Regulatory or Cytotoxic T Cell Immunotherapy with Rational Nanomaterial Design, Tarek Fahmy, Yale University

2:00 p.m.211. Determining the Specificity of a Multivalent Polymeric Antigen-Specific Immunotherapy for Multiple Sclerosis, B. L. Hartwell*, J. O. Sestak, B. P. Sullivan, H. Shinogle, C. Berkland, University of Kansas, Lawrence, KS

2:15 p.m. 212. Intra-lymph Node Delivery of Biomaterial Depots Prevents and Reverses Experimental Autoimmune Encephalomyelitis, L. H. Tostanoski*, Y. Chiu, J. M. Gammon, C. M. Jewell, University of Maryland - College Park, College Park, MD

2:30 p.m. 213. Current Translation Efforts for a Microparticle-Based Vaccine against Type 1 Diabetes, J. Lewis*(1), M. Carstens(1), N. Dolgova(1), G. Marshall(2), S. Morshed(1), C. Xia(1), M. Clare-Salzler(2), B. Keselowsky(1), (1)University of Florida, Gainesville, FL, (2)OneVaxx, LLC, Gainesville, FL, (2)University, Gainesville, FL

2:45 p.m. 214. Anti-Cytokine Responses Elicited by Self-assembling Peptide Vaccines, C. Mora Solano*(1), R. Pompano(2), J. Collier(1), (1)University of Chicago, Chicago, IL, (2)University of Virginia, Charlottesville, VA

3:00 p.m. 215. Tuning CD8+ T cell Multifunctionality with Peptide Self-assemblies, C. B. Chesson*, R. J. Nusbaum, J. J. Endsley, J. S. Rudra, University of Texas Medical Branch, Galveston, TX

3:15 p.m. 216. Electrospun Poly(dimethyl siloxane)-based Meshes as a Platform for T Cell Expansion, A. Dang*(1), S. De Leo(1), D. Bogdanowicz(1), H. Lu(2), L. Kam(1), (1)Columbia University, New York, NY, (2)Columbia University, Engineering Terrace Rm. 351, NY

Multifunctional Nanomaterials for Engineering Complex Tissues and Drug Delivery

1:30 p.m. 223. Collagenase Delivery from Multi-Polymer Fibrous Scaffolds To Promote Cellular Mobility and Meniscus Repair, J. L. Holloway*, F. Qu, I. L. Kim, R. L. Mauck, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

1:45 p.m. 224. Nanoengineered Bioactive Hydrogels for Cells-based Tissue Engineering, J. R. Xavier, T. Thakur, P. Desai, A. K. Gaharwar*, Texas A&M University, College Station, TX

2:00 p.m. 225. Fluorogen-Activating Proteins as Retention Modules for Local Deposition of Antibodies, W. S. Meng*(1), W. Liu(1), M. Saunders(2), A. Waggoner(2), (1)Duquesne University, Pittsburgh, PA, (2)Carnegie Mellon University, Pittsburgh, PA

2:15 p.m. 226. Engineering Micropores in Nanoparticle-bacterial Cellulose Scaffolds using a Laser-cutting Instrument: Preparation, hMSCs Proliferation and Osteogenic Differentiation for Bone Tissue Regeneration, P. M. Favi*(1), S. P. O. Alvarez(2), T. J. Webster(1), (1)Northeastern University, Boston, MA, (2)University of Antioquia, Medelln, Colombia

2:30 p.m. 227. Self-Assembly of Highly Asymmetric Polypeptide Amphiphiles, I. Weitzhandler*(1), J. R. McDaniel(3), S. Prevost(2), M. Gradzielski(2), A. Chilkoti(1), (1)Duke University, Durham, NC, (2)Technische Universitat Berlin, Berlin, Germany, (3)University of Texas at Austin, Austin, TX

2:45 p.m. 228. Investigation of Dendrimer-Based Nanoparticles Cellular Uptake and Cell Tracking in a Semi-Automated Microfluidic Platform, M. R. Carvalho*(1), J. Mano, Sr.(1), R. L. Reis(2), J. M. Oliveira, Sr.(1), (1)3B's Research Group of University of Minho, Guimares, Portugal, (2)3B's Research Group, Guimares, Portugal

3:00 p.m. 229. Designing Recombinant Baculovirus/Nanomaterial based Hybrid Hydrogels for Gene Delivery Application, A. Paul, Jr.*, University of Kansas, Lawrence, KS

3:15 p.m. 230. Folate-functionalized Polymeric Micelle for Combinatorial Therapy to Overcome Drug Resistant Breast Cancer, J. S. Lee*, Clemson University, Greenville, SC

PANEL DISCUSSION: ICF Fellows Session: Is Translational Research More Impactful Than Basic Science Research (A Debate)

217. Mauli Agrawal The University of Texas at San Antonio

218. Andres Garcia Georgia Institute of Technology

219. David Grainger University of Utah

220. John Kao University of Wisconsin

221. Michael Sefton University of Toronto

222. Stuart Cooper The Ohio State University

Stem Cell and Biomaterial Interactions

1:30 p.m. 231. Invited Speaker: Kevin Healy, University of California at Berkeley

2:00 p.m. 232. Integrin Alpha 2 Beta 1-Specific Hydrogels Enhance Human Mesenchymal Stem Cell Survival and Bone Repair in Vivo, A. Y. Clark*, A. J. Garcia, Georgia Tech, Atlanta, GA

2:15 p.m. 233. In Situ Vascularization of Injectable Fibrin/Poly(Ethylene Glycol) Hydrogels by Human Amniotic Fluid Stem Cells, O. M. Benavides(1), A. R. Brooks(1), S. Cho(1), J. Petsche Connell(1), R. Ruano(2), J. G. Jacot*(1), (1)Rice University, Houston, TX, (2)Baylor College of Medicine, Houston, TX

2:30 p.m. 234. Engineering 3D Sliding Hydrogels with Mobile Molecular Ligands to Direct Stem Cell Differentiation, X. Tong*, F. Yang, Stanford University, Stanford, CA

2:45 p.m. 235. Disruption of Cell-Cell Contact-mediated Notch Signaling via Hydrogel Encapsulation Reduces Mesenchymal Stem Cell Chondrogenic Potential, A. Chen*(1), M. Hoffman(2), C. Chen(3), A. D. Shubin(2), D. S. Reynolds(4), D. S. W. Benoit(2), (1)University of Cambridge, Cambridge, United Kingdom, (2)University of Rochester, Rochester, NY, (3)University at Buffalo, Buffalo, NY, (4)Boston University, Boston, MA

3:00 p.m. 236. Heparin Cell Coating Maintains Cell Number During Mesenchymal Stem Cell Aggregate Culture, J. Lei*, J. S. Temenoff, Georgia Institute of Technology, Atlanta, GA

3:15 p.m. 237. Direct Hydrogel Encapsulation of Pluripotent Stem Cells Enables Formation of Engineered Cardiac Tissues, P. Kerscher*(1), I. C. Turnbull(2), A. J. Hodge(1), J. Kim(1), D. Seliktar(3), C. J. Easley(1), K. D. Costa(2), E. A. Lipke(1), (1)Auburn University, Auburn, AL, (2)Icahn School of Medicine at Mount Sinai, New York, NY, (3)Technion-Israel Institute of Technology, Haifa, Israel