2nd Annual SFB Business Plan Competition

3:00 p.m. 342. Ancure, LLC: Controlled Release Solutions for Treating Brain Aneurysms, M. Cramer*, A. Iftikhar, M. Horowitz, C. Bettinger, Carnegie Mellon University, Pittsburgh, PA

3:15 p.m. 343. Marauder Medical Devices: Novel Lung Assist Device for Preterm and Term Neonates, D. Sandejas*, H. Matharoo*, McMaster University, Hamilton, ON, Canada

3:30 p.m. 344. Evoke Medical: Stimulating a Pathway to Bone Healing, N. Galvis*(1), E. Cadel(1), H. Sis(1), B. Wong(1), P. M. Arnold(2), E. A. Friis(1), (1)University of Kansas, Lawrence, KS, (2)Kansas University Medical School, Kansas City, KS

3:45 p.m. 345. MacroTheranostics: A Macrophage-based Therapeutic and Diagnostic Wound Care Company, S. Nassiri*, K. L. Spiller, Drexel University, Philadelphia, PA

4:00 p.m. 346. Nanochon: Novel 3D Printed Joint Repair Scaffolds, B. Holmes*, N. Castro, L. G. Zhang, GWU, Washington, DC

4:15 p.m. 347. OsteoInk: Bioactive Bone Cements, J. Chari*, L. C. Rodriguez, D. C. Rodrigues, The University of Texas at Dallas, Richardson, TX

Presentations will be followed by a brief Q&A and judging.

Bio-Inspired Cellular Microenvironments

3:00 p.m. 348. Selectin-Mediated Cell Adhesion on Glycoprotein-Conjugated Hydrogels, Y. Iwasaki*, A. Matsunaga, S. Sugimoto, Kansai University, Suita, Osaka, Japan

3:15 p.m. 349. Altered Extracellular Matrix Properties Drive Tumor Progression, K. Wang*, M. Quien, L. Hsu, W. Lewis, C. Fischbach, D. Gourdon, Cornell University, Ithaca, NY

3:30 p.m. 350. PEG-fibrinogen Hydrogel Microspheres Support 3D Tumorigenic Growth of MCF7 Breast Cancer Cells, S. Pradhan(1), J. Clary(1), D. Seliktar(2), E. A. Lipke*(1), (1)Auburn University, Auburn, AL, (2)Technion-Israel Institute of Technology, Haifa, Israel

3:45 p.m. 351. Bio-Inspired Lymphoid Tissues for Immune Cell Cancers, Y. F. Tian*(1), R. S. Schneider(1), L. Cerchietti(2), A. Singh(1), (1)Cornell University, Ithaca, NY, (2)Weill Cornell Medical College of Cornell University, New York City, NY

4:00 p.m. 352. Cell Guidance into Quiescent State through Chromatin Remodelling Induced by Elastic Modulus of Substrate, M. Rabineau*, F. Flick, B. Senger, P. Lavalle, P. Schaaf, J. Freund, D. Vautier, French National Institute for Health and Medical Research (Inserm), Strasbourg, France

4:15 p.m. 353. Hydrogel Arrays to Screen Angiogenesis Inhibitors and Vascular Disrupting Compounds, D. G. Belair*, M. P. Schwartz, W. L. Murphy, University of Wisconsin-Madison, Madison, WI

4:30 p.m. 354. Biomimetic Electrospun Scaffolds with Topographical Cues Induce Osteoblast Maturation, R. Olivares-Navarrete*, S. Ayad, S. Cameron, I. Khatri, D. Mason, B. Vendra, Virginia Commonwealth University, Richmond, VA

4:45 p.m. 355. Bioinspired Silicate Nanocomposites for Osteoarthritis Therapy, J. Carrow*, G. Lokhande, A. K. Gaharwar*, Texas A&M University, College Station, TX

Biomimetic Materials for Tissue Engineering 2

3:00 p.m. 356. Creating Liver-Mimicking Tissue Constructs in a 3D Biomimetic Hydrogel, H. Bearat*, J. West, Duke University, Durham, NC

3:15 p.m. 357. Surface Grafting of Chitosan-Coated Electrospun Fibers to Promote Cell Adhesion, A. S. Goldstein*, P. Vaidya, T. Z. Grove, Virginia Tech, Blacksburg, VA

3:30 p.m. 358. A 3D Hydrogel Model of Tumor Angiogenesis to Study the Role of Vascular Cells in Tumor Progression, L. C. Roudsari*(1), A. S. Witt(1), J. M. Kurie(2), J. L. West(1), (1)Duke University, Durham, NC, (2)The University of Texas MD Anderson Cancer Center, Houston, TX

3:45 p.m. 359. Culture Platform to Assess the Effect of Hydroxyapatite Properties on Breast Cancer Cells, S. Choi*, L. A. Estroff, C. Fischbach, Cornell University, Ithaca, NY

4:00 p.m. 360. Regulating Endothelial Cell Dynamics through Peptide-Encoded Material Compliance, R. M. Schweller*, J. L. West, Duke University, Durham, NC

4:15 p.m. 361. Biomimetic Fibrous Hydrogels with Aligned Hierarchical Structure Promote Biomineralization in Vitro, A. Patel*, V. Sant, S. Sant, University of Pittsburgh, Pittsburgh, PA

4:30 p.m. 362. Plastically Compressed Bioglass Incorporated Collagen Matrices for Orthopedic Applications, G. Liu, M. B. Fenn, L. L. Hench, V. Kishore*, Florida Institute of Technology, Melbourne, FL

4:45 p.m. 363. Hyaluronic Acid Hydrogels that Emulate the Pro-osteogenic Niche Enhance the Osteogenesis of hMSCs, L. Bian*(1), M. Zhu(1), Q. Feng(2), (1)The Chinese University of Hong Kong, Hong Kong, Hong Kong, (2)The Chinese University of Hong Kong, Shatin, Hong Kong

Ceramics and Composites in Bone Tissue Engineering and Drug Delivery 2

3:00 p.m. 364. Biologically Inspired Scaffold Mimicking Trabecular Bone in a Rabbit Spinal Fusion Model, S. Minardi*(1), B. Corradetti(2), F. Taraballi(2), M. Sandri(1), J. Van Eps(2), F. Cabrera(2), B. Weiner(2), A. Tampieri(1), E. Tasciotti(2), (1)National Research Council of Italy - ISTEC, Faenza, Italy, (2)Houston Methodist Research Institute, Houston, TX

3:15 p.m. 365. Reinforced Magnesium Phosphate Cement with Wet-spun PCL Fibers, N. J. Ostrowski*, V. Sharma, J. Ohodnicki, A. Roy, P. N. Kumta, University of Pittsburgh, Pittsburgh, PA

3:30 p.m. 366. Longitudinal Evaluation of Bioactive Strip Implanted into the Distal Condyle of New Zealand White Rabbits, Z. Tosun*, G. Pomrink, NovaBone Products, Alachua, FL

3:45 p.m. 367. Preparation and Characterization of Poly (hydroxybutyrate co hydroxyvalerate) Nanofibers Containing Sol-gel Derived Bredigite for Bone Regeneration Applications, M. Kouhi*(1), M. Fathi(1), M. Shamanian(1), M. P.Prabhakaran(2), S. Ramakrishna(2), (1)Isfahan University of Technology(IUT), Iran., Isfahan, Iran, (2)National University of Singapore, Singapore, Singapore

4:00 p.m. 368. Release and Activity of Adenosine Incorporated Into Calcium Sulfate, E. C. Duncan*, D. Carpenter, W. Haggard, J. A. Jennings, University of Memphis, Memphis, TN

4:15 p.m. 369. Reinforcement of Injectable Calcium Phosphate Cement by Gelatinized Starches, L. Yang*, H. Liu, Y. Guan, H. Yang, Soochow University, Suzhou, China

4:30 p.m. 370. Hydroxyapatite-Titanium Composites with Outstanding Fracture Toughness and Cytocompatibility Properties for the Bone Tissue Engineering Applications, A. Kumar*(1), M. Saxena(2), K. Biswas(2), B. Basu(1), (1)Indian Institute of Science, Bangalore, India, (2)Indian Institute of Technology Kanpur, Kanpur, India

4:45 p.m. 371. Multifunctionality and Electrical Stimulation Induced Cellular Response of Hydroxyapatite-Barium Titanate Piezobiocomposite, B. Basu*, A. K. Dubey, G. Thrivikraman, Indian Institute of Science, Bangalore, India

Drug Delivery

3:00 p.m. 372. Selectively Decreasing Malignant Melanoma Cell Viability with Polymersomes Loaded with Protoporphyrin IX (PPIX), M. Wang*, B. Geilich, H. Homayoni, E. Ebong, T. Webster, The Northeastern University, Boston, MA

3:15 p.m. 373. Sustained Suppression of Mitochondrial Oxidative Stress using Curcumin conjugated Poly (beta-Amino Esters) Nanogels., P. Gupta*, J. Z. Hilt, T. D. Dziubla, University of Kentucky, Lexington, KY

3:30 p.m. 374. Poly(beta-amino ester) nanoparticles for selective and combinatorial delivery of siRNA to brain cancer, K. L. Kozielski*, H. Vaughan, B. H. Kim, S. Y. Tzeng, H. Guerrero-Cazares, A. Quinones-Hinojosa, J. J. Green, Johns Hopkins University, Baltimore, MD

3:45 p.m. 375. Photo-polymerized keratin-PEG sponge for growth factor delivery in bone tissue engineering, R. de Guzman*, Hofstra University, Hempstead, NY

4:00 p.m. 376. ON-OFF Fluorescent Micelles as a Transdermal Drug &Vaccine Delivery System, D. Velluto*, Northwestern University, Evanston, IL

4:15 p.m. 377. Modeling of Drug Release Kinetics from Porous Ceramic Disks, A. U. Joshi*, H. P. Cherukuri, The University of North Carolina at Charlotte, Charlotte, NC

4:30 p.m. 378. An Injectable and Thermosensitive Hydrogel Capable of Delivering Matrix Metalloproteinases 2 Inhibitor to Control Myocardial Remodeling, Z. Fan*, M. Fu, B. Zhang, Z. Li, X. Li, Y. Xu, J. Guan, The Ohio State University, Columbus, OH

4:45 p.m. 379. Evaluation of Controlled Delivery of Carboplatin from a Poly-Ether-Ester Urethane System in a Murine Model, D. R. Ingram*, J. M. Olbrich, J. T. Corbett, Poly-Med, Inc., Anderson, SC

Engineering Tissue Interfaces

3:00 p.m. 380. Recapitulating the Architecture of Cells of Interest Using Cell-Derived, Biomimetic Patterning, J. H. Slater*(1), J. C. Culver(2), B. L. Long(3), C. W. Hu(3), J. Hu(3), T. F. Birk(3), A. A. Qutub(3), M. E. Dickinson(4), J. L. West(5), (1)University of Delaware, Newark, DE, (2)University of California San Francisco School of Medicine, San Francisco, CA, (3)Rice University, Houston, TX, (4)Baylor College of Medicine, Houston, TX, (5)Duke University, Durham, NC

3:15 p.m. 381. Dose-Dependent Effects of CDA on Chondrocyte Response on Polymer-Ceramic Composite Scaffolds, M. K. Boushell*(1), K. R. Caparino(2), H. H. Lu(1), (1)Columbia University, New York, NY, (2)Columbia University, Plainsboro, NJ

3:30 p.m. 382. Patterning Biochemical Signals into Nanofibrous Hydrogels to Spatially Control Cell Behavior, R. J. Wade*(1), E. J. Bassin(1), W. M. Gramlich(2), J. A. Burdick(1), (1)University of Pennsylvania, Philadelphia, PA, (2)University of Maine, Orono, ME

3:45 p.m. 383. Mechanical Loading of 3D multi-Compartment Scaffolds for Spatial Control of hMSC Fate for Regeneration of Orthopedic Interfaces, W. K. Grier*, S. R. Caliari, A. S. Moy, B. A. Harley, University of Illinois at Urbana-Champaign, Urbana, IL

4:00 p.m. 384. Cartilage Lubrication through Peptide-mediated Hyaluronic Acid Binding and Retention, A. Singh*, M. Corvelli, H. Jacobs, J. Elisseeff, Johns Hopkins University, Baltimore, MD

4:15 p.m. 385. Evaluation of Anterior Cruciate Ligament Insertion Site Fibrochondrocytes on Nanofiber Scaffolds, D. Qu*, H. Park, J. P. Zhu, H. H. Lu, Columbia University, New York, NY

4:30 p.m. 386. Influence of Sparse Electrospun Fibers on the Differentiation of Mesenchymal Stem Cells in Collagen Gels, P. Thayer*, E. Tong, N. Butler-Abisrror, A. Goldstein, Virginia Tech, Blacksburg, VA

4:45 p.m. 387. Rotational Dual Chamber Bioreactor for Interfaced Engineered Tissue Models, R. F. Canadas*, A. P. Marques, J. M. Oliveira, R. L. Reis, 3B's Research Group of University of Minho, Guimaraes, Portugal

Molecular Mechanisms Governing Protein-Surface and Cell-Surface Interactions

3:00 p.m. 388. Angiogenic Methacrylic Acid Copolymers Adsorb Different Proteins and Result in Lower Complement Activation in Comparison to Poly (Methyl Methacrylate), L. A. Wells*(1), H. Guo(2), A. Emili(2), M. V. Sefton(2), (1)Queen's University, Kingston, ON, Canada, (2)University of Toronto, Toronto, ON, Canada

3:15 p.m. 389. Factor XII Contact Activation Products Show Self-Inhibition, L. Xu*(1), Y. Xu(2), E. A. Vogler(3), C. A. Siedlecki*(1), (1)Penn State University, Hershey, PA, (2)Hershey High School, Hershey, PA, (3)Penn State University, University Park, PA

3:30 p.m. 390. Interfacial Segregation of PEG in Hydrophobic Polymers and Its Influence on Protein Adsorption, N. S. Murthy*(1), W. Wang(2), W. R. Lindemann(2), N. A. Anderson(2), D. Vaknin(2), J. Kohn(1), (1)Rutgers University, Piscataway, NJ, (2)Iowa State University, Ames, IA

3:45 p.m. 391. Influence of Chemical Additives on the Structure and Biological Activity of Proteins Pre-adsorbed on Material Surfaces Using an Improved Circular Dichroism Methodology, A. A. Thyparambil*, Y. Wei, R. A. Latour, Clemson University, Clemson, SC

4:00 p.m. 392. Molecular Insights into the Gel to Liquid-Crystalline Phase Transition of Phospholipid Bilayers, L. Weng*, G. D. Elliott, University of North Carolina at Charlotte, Charlotte, NC

4:15 p.m. 393. FXIIa Products Produced by Surface Contact Activation, Y. Yan*, L. Xu, C. A. Siedlecki, The Pennsylvania State University, College of Medicine, Hershey, PA

4:30 p.m. 394. The Phosphoproteomics Landscape of the Interaction between Biomaterials and Cells, D. Chamberlain*, L. Wells, S. lisovsky, M. Sefton, University of Toronto, Toronto, ON, Canada

4:45 p.m. 395. Surface Design of Heparin-Functionalized Thermoresponsive Cell Culture Substratesfor Maintaining Hepatic Functions and Harvesting Cultured Hepatocyte Sheets, J. Kobayashi*, Y. Arisaka, K. Ohashi, K. Tatsumi, K. Kim, Y. Akiyama, M. Yamato, T. Okano, Tokyo Women's Medical University, Tokyo, Japan

Panel Discussion: Polyurethanes: From Materials Development to Device Evaluation and Back Again

396. History of Biomedical Polyurethanes, Jim Anderson, Case Western Reserve University

397. Scale Up of Thermoplastic Polyurethanes and Silicone-Polyurethanes for Implantable Devices, Bob Ward, ExThera Medical

398. Development and Characterization of Polyisobutylene Polyurethanes, Pat Willoughby, Boston Scientific

Product Development, Regulatory Approval, and Post-market Monitoring of Implantable Medical Devices Utilizing a Novel Silicone Polyurethane, Chris Jenney, St. Jude Medical

Development of New Biodegradable Polyurethanes for Resorbable Devices, Scott Guelcher, Vanderbilt University