New this year! In an effort to create a gathering/networking area for Special Interest Group members, and to make the poster area more interesting for attendees, all posters have been assigned to one of 14 SIGs. Each SIG area will be clearly labeled with a large banner suspended from the rigging in the exhibit/poster area. We realize many posters would be appropriate for than one SIG so we assigned each poster to an area based on the primary SIG that the abstract was submitted to. We hope you enjoy this new layout!

Biomaterials and Medical Products Commercialization SIG

*BTI* Commercialization of Biomaterials and Medical Products

500. Biomineral Coating Promotes Osteostimulatory Responses of PEEK Implants
L. Jongpaiboonkit*1, N. Caras1, W. Murphy2, 1Tissue Regeneration Systems, Inc., Plymouth, MI, 2University of Wisconsin, Madison, WI

501. A Data Analytics Approach for Optimization of Hernia Mesh for Ventral Hernia Repair Through the Identification of Patient Subpopulations and the Correlation of Patient Outcomes to Implant Material
R. L. Slappy*1, R. E. Heidel2, E. D. Barker1, B. J. Ramshaw3, D. A. Grant4, S. A. Grant4, 1University of Tennessee at Knoxville, Knoxville, TN, 2University of Tennessee Medical Center at Knoxville, Knoxville, TN, 3University of Tennessee Graduate School of Medicine, Knoxville, TN, 4University of Missouri, Columbia, MO

502. Synthesis, Degradation, and Mechanical Properties of Strataprene® 3534, an Elastic-like Bioresorbable Polymer
S. McCullen*, V. Rodriguez-Rivera, S. Taylor, Poly-Med, Inc., Anderson, SC

503. Mechanical and Microstructural Analysis of an Expandable Vascular Conduit for Pediatric Cardiovascular Surgery
D. Faulk*1, A. Loneker2, S. Luketich2, D. Bernstein1, A. Kalra1, A. D'Amore2, 1PECA Labs, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA

*BTI* From Benchtop to Clinical Trial: Examples of technology development

504. Supercritical Fluid Processing Applications in Biomaterials
M. R. Favaloro*, Phasex, Amesbury, MA

Active Wound Dressings for Advanced Wound Care

505. pH Sensitive Methacrylated Chitosan Hydrogels with Tunable Physical and Chemical Properties
L. Zhu*, Iowa state university, Ames, IA

506. Rapid Hemostasis Without Compression Using a Novel Composite Biopolymer Gel
O. Ahmad*, Y. Sapir-Lekhovitser, J. Lee, W. Luo, J. Landolina, Cresilon, Inc., Brooklyn, NY

507. A Collagen-Based Cell Spray Adhesive
C. Simpliciano*, J. Hollenstein, J. Burgin, Collagen Solutions, San Jose, CA

508. Antibacterial and Biocompatible Hyaluronic acid-Calcium Fluoride Nanocomposite Hydrogel for Effective Wound Healing
S.-H. Jeong*, D.-Y. Shin, E.-H. Song, H.-E. Kim, Seoul National University, Seoul, Republic of Korea

509. Multifunctional Biopolymer Hydrogel for Diabetic Foot Ulcer Treatment
A. M. Heimbuck*1, J. S. Alexander2, M. E. Caldorera-Moore1, 1Louisiana Tech University, Ruston, LA, 2Louisiana State University Health Sciences Center- Shreveport, Shreveport, LA

510. Characterization of Novel Sol-Gel Derived Bioactive Glass Formulations for Hemostatic and Bone Grafting Applications
C. Goldbach*1, M. Demir1, D. Rodriguez1, G. Pomrink1, L. Howell2, 1NovaBone Products, Alachua, FL, 2Particle Solutions, Alachua, FL

511. Fluoride Releasing Alginate Composite Hydrogel for Antibacterial Wound Dressing
D. Y. Shin*, S.-H. Jeong, M.-H. Kang, H.-E. Kim, Seoul National University, Seoul, Republic of Korea

512. Evaluation of Electrospun Scaffolds for Closing Full and Partial Thickness Wounds
R. B. Diller*, R. S. Kellar, Northern Arizona University, Flagstaff, AZ

513. Characteristics of Biological Skin Substitute Derived from Bioactive Collagen Matrix to Treat Wounds and Ulcers
S. S. G. Gunasekaran*, ENCOLL Corp., Fremont, CA

Biomaterials and Medical Products Commercialization

514. Investigating a Chandler Loop System for Thrombogenicity Testing of Biomaterials
J. Yau*, M. Jamiolkowski, R. Malinauskas, Q. Lu, US Food and Drug Administration, Silver Spring, MD

515. Effect of Sodium Azide Concentration on Wear and Bacteria Growth in a Knee Simulation Test
E. Hippensteel, A. Metcalfe*, B. Owens, E. Stumpf, J. Langhorn, DePuy Synthes Joint Reconstruction, Warsaw, IN

516. Novel Cyanoacrylate Monomers for Internal Wound Approximation: A Preliminary Study
K. J. Garcia*, M. S. Taylor, J. T. Corbett, Poly-Med, Inc., Anderson, SC

517. Factors Influencing Anchoring Performance of Polydioxanone Barbed Surgical Sutures
Y. Huang1, G. L. Ruff2, S. C. Roe1, J. H. Cole(1,3), M. W. King1, H. Cong*1, 1North Carolina State University, Raleigh, NC, 2Plastic surgeon, Chapel Hill, NC, 3University of North Carolina at Chapel Hill, Raleigh, NC

518. Efficacy of the Mixture of Hyaluronic acid and Hydroxyethyl starch in Prevention of Adhesion after Endoscopic Sinus Surgery
K.-S. Kim*1, H.-M. Lee2, 1Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea, 2Korea University College of Medicine, Seoul, Korea, Seoul, Republic of Korea

Biomaterial-Tissue Interaction SIG

519. Estimating Worst-Case Ni Release in Benchtop Studies of Nitinol
E. M. Sussman*, S. Loh, V. Chandrasekar, P. Mannuel, S. Sivan, J. Weaver, M. Di Prima, D. Saylor, US Food and Drug Administration, Silver Spring, MD

520. Histological Analysis of Subcutaneously Implanted PEG-Collagen With Crosslinked Chondromodulin-1 and VEGF-C
L. T. Lang*1, D. A. Foyt2, R. C. de Guzman2, 1Hofstra University, Wantagh, NY, 2Hofstra University, Hempstead, NY

521. Self-assembled Bionanomatrix Coated Coils for Intracranial Aneurysm Healing
P. Hwang*1, M. Collier2, G. Alexander2, B. Brott1, R. Hergenrother2, D. Kallmes3, R. Kardivel3, H.-W. Jun1, 1Endomimetics, LLC, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Mayo Clinic, Rochester, MN

522. Adhesive Alginate-Based Patch System for Lung Tissue Repair
S. L. Fenn*, P. N. Charron, R. A. Oldinski, The University of Vermont, Burlington, VT

523. Developing a mobileHealth Solution for Treatment of Plantar Fasciitis
J. A. McGreevey*, Clemson, Seneca, SC

524. Engineering a Highly Elastic Protein-based Surgical Sealant
N. Annabi*1, Y.-N. Zhang2, A. Assmann2, A. Vegh2, G. Cheng3, B. Dehghani2, S. Gangadharan3, A. Weiss4, A. Khademhosseini2, 1Northeastern University, Boston, MA, 2Harvard Medical School, Boston, MA, 3Beth Israel Deaconess Medical Center, Boston, MA, 4Sydney University, Sydney, Australia

525. Comparative Pressure Analysis of Biomaterial Solutions in Pig Urinary Bladders
H. Reyna*1, R. c. deGuzman2, 1Hofstra Univerity, uniondale, NY, 2Hofstra University, Hempstead, NY

526. Host Response and Degradation Profile for Synthetic Surgical Meshes Used in Abdominal Wall Repair
M. Sandor*1, M. Edwards1, P. Assan2, A. Hoonjan1, H. Xu1, 1LifeCell Corporation, Bridgewater, NJ, 2Integra LifeSciences, Plainsboro, NJ

527. Modulation of Human Stem Cell Behavior using Monolayer Binary Colloidal Crystals
P. Wang*, H. Thissen1, P. Kingshott2, 1CSIRO Manufacturing, Melbourne, Australia, 2Swinburne University of Technology, Melbourne, Australia

528. Systems Analysis Identifies Core Components of Foreign Body Response to Biomaterial Implants
J. Doloff*1, O. Veiseh1, A. Vegas1, S. Farah1, HH. Tam1, M. Ma1, A. Sadraei1, J. Oberholzer2, D. Greiner3, R. Langer1, D. Anderson1, 1Massachusetts Institute of Technology, Cambridge, MA, 2University of Illinois at Chicago, Chicago, IL, 3UMass Medical, Worcester, MA

529. Chitosan Hydrogel is More Effective than Chitosan Fluid to Prevent Postsurgical Abdominal Adhesion Formation
Y.-L. Sun*, L.-X. Lin, F. Yuan, H.-H. Zhang, D. Huang, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Immune Engineering SIG

*BTI* Commercialization of Biomaterials and Medical Products

530. Thixotropic Hydrogels for Antibacterial Application
K. Stipe*, B. Serban, J. Alverson, N. Priestley, M. Serban, University of Montana, Missoula, MT

Advances in Antimicrobial Biomaterials

531. The Effect of Nanogratings on Bacterial Attachment and Aggregation
C. Q. Lai*, Nanyang Technological University, Singapore, Singapore

532. - Withdrawn

533. Antibacterial Potential of Platelet Lysate Membranes for Orthopedic Applications
R. Costa-Almeida*, A. R. Franco, I. B. Leonor, P. S. Babo, R. L. Reis, M. E. Gomes, 3B’s Research Group, University of Minho, Guimarães, Portugal

534. Bacteriostatic Characteristics of Silicon Nitride, Polyetheretherketone, and Titanium Biomaterials
B. J. McEntire*1, E. N. Jones1, D. A. Ray1, R. M. Bock1, B. S. Bal2, G. Pezzotti3, 1Amedica Corporation, Salt Lake City, UT, 2University of Missouri Health System, Columbia, MO, 3Kyoto Institute of Technology, Kyoto, Japan

535. Antibacterial Properties of Magnesium and Platinum Doped Hydroxyapatite Nanoparticles
J. S. Caballero Sarmiento*, C. G. Paucar Alvarez, National University of Colombia, Medellín, Medellín, Colombia

536. Preparation and Characterisation of Acrylate-Based Microparticles, of Varying Compositions and Sizes, for Photosensitiser Incorporation
C. P. McCoy, J. V. Moore*, N. J. Irwin, L. Carson, G. P. Andrews, Queen's University Belfast, Belfast, United Kingdom

537. Stable Encapsulation of Triangular Silver Nanoplates with a Silica Shell for Targeted and Photothermal
C.-S. Chiang*, M. Wang, T. J. Webster, Northeastern University, Boston, MA

538. - Withdrawn

Advances in Antimicrobial Biomaterials

539. Amino Acid – Based Zwitterionic Antifouling Polymers: Development, Biofouling Properties and Applications
W. Li*, Q. Liu, L. Liu, University of Akron, Akron, OH

Biomaterials for Immunotherapy

540. The Effect of Polyanhydride Chemistry in Particle-based Cancer Vaccines on the Magnitude of the Antitumor Immune Response.
E. I. Wafa*1, S. M. Geary1, J. T. Goodman2, B. Narasimhan2, A. K. Salem1, 1University of Iowa, Iowa City, IA, 2Iowa State University, Ames, IA

541. - Withdrawn

542. Photothermal Therapy in Combination with Immunotherapy to Inhibit Cancer Growth and Metastasis
J. Chen*, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China

Delivery of Therapies to Suppress Autoimmunity and Enhance Transplant Performance

543. Development of Tacrolimus-Loaded Polymeric Local Delivery System for Immunosuppression
J. Molde*1, K. Dude1, C. Iovine1, A. Merrolli1, O. Ortiz1, Z. Yang Ng2, C. L. Cetrulo2, J. Kohn1, 1Rutgers University, Piscataway, NJ, 2Harvard University, Charlestown, MA

544. Drug Delivery by Transplanted Islets
R. R. Kane*1, B. Akinbobuyi1, C. A. Chang1, B. Naziruddin2, 1Baylor University, Waco, TX, 2Baylor Scott & White Health, Dallas, TX

545. Immune-suppressive Hydrogels for Stem Cell Therapy After Traumatic Brain Injury
M. Alvarado-Velez*1, J. Chu2, M. LaPlaca1, R. Bellamkonda3, 1Georgia Institute of Technology, Atlanta, GA, 2Emory University, Atlanta, GA, 3Duke University, Durham, NC

546. Generating Injectable, Functional Thymus Organoids with Self-Assembling Hydrogel to Restore Adaptive Immune Function
S. Wong-Noonan*1, L. Wen2, I. Pradhan1, S. Bertera1, R. Lakomy1, M. Trucco1, W. S. Meng2, Y. Fan1, 1Allegheny Health Network, Pittsburgh, PA, 2Duquesne University, Pittsburgh, PA

Engineering Materials and Delivery Systems for Modern Vaccines

547. Dendritic Cell Targeted Nano-vaccine Delivery System Engineered from a Plant Polymer Based Toll-Like Receptor-4 Agonist Inulin Acetate.
S. S. Kesharwani*1, M. Rajput1,2, S. Kumar1, S. Narishetty1, H. Tummala1, 1South Dakota State University, Brookings, SD, 2Michigan State University, East Lancing, MI

548. pH-induced Vomocytosis for Intra-lymph Nodal Delivery of Microparticle Vaccines
A. Bolandparvaz*, J. Ma, A. Zhou, J. Lewis, University of California, Davis, Davis, CA

549. Harnessing Controlled Release Polymer-nanoparticle Hydrogel to Produce Robust Long-term Immunity
G. Agmon*1, A. C. Yu2, D. Chan2, A. M. Sevit2, E. A. Appel2, 1Stanford, Los Altos, CA, 2Stanford, Stanford, CA

550. Sunitinib-Loaded Polymeric Nanoparticles to Deplete Myeloid-Derived Suppressor Cells and Enhance the Efficacy of a Cancer Immunotherapy
C. M. de Barros*, S. Geary, A. Salem, University of Iowa, Iowa City, IA

Immunomodulation in Regenerative Medicine

551. The Effect of Cell Debris within Biologic Scaffolds upon the Host Response
R. Londono*1, J. L. Dziki1, E. Haljasmaa1, N. Turner1, C. Leifer2, S. F. Badylak1, 1University of Pittsburgh, Pittsburgh, PA, 2Cornell University College of Veterinary Medicine, Ithaca, NY

552. Differentiation and Heterogeneity of Biomaterial-induced Multinucleated Giant Cells: Connection between Inflammation and Tissue Regeneration
M. Barbeck*1, P. Booms2, R. Unger3, C. J. Kirkpatrick4, 1Private office, Berlin, Germany, 2FORM-Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany, 3Institute of Pathology, Repair-Lab, University Medical Center of the Johannes Gutenberg University, Mainz, Germany, 4Department of Biomaterials, Sahlgrenska Academy, University of Gothenburg, Sweden

553. Keratin Biomaterials Augment Anti-inflammatory Macrophage Phenotype in-vitro
M. Waters*, P. VandeVord, M. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, VA

554. The Effect of Methacrylate Anhydride Modified Gellan Gum Hydrogels on both Macrophage and Fibroblast Phenotypes
Z. Li*, K. Bratlie, Iowa State University, Ames, IA

555. Establishment of NF-kB Sensing and IL-4 Secreting Mesenchymal Stem Cells as an “On-demand” Drug Delivery System to Modulate Inflammation
T.-H. Lin*, J. Pajarinen, A. Nabeshima, L. Lu, K. Nathan, Z. Yao, S. Goodman, Stanford University, Palo Alto, CA

556. Role of Macrophage-Produced Cytokines by Stimulation of Calcium Phosphate Ceramics in the Material-Mediated Osteoblastic Differentiation of Mesenchymal Stem Cells
X. Zhu*, J. Wang, X. Zhang, Sichuan University, Chengdu, China

557. Prostaglandin Immobilized Scaffold Regulate Inflammation and Osteogenesis in Bone Regeneration
Y. Liu*, Q. Yao, H. Sun, University of South Dakota, Sioux Falls, SD

558. Treatment of Particle Induced Osteolysis with Delayed IL-4 Delivery in a Novel Murine Model
J. Pajarinen*, A. Nabeshima, T.-H. Lin, T. Sato, L. A. Cordova, E. Gibon, F. Loi, L. Lu, K. Nathan, Z. Yao, S. Goodman, Stanford University, Palo Alto, CA

559. A Gold Nanoparticle-Based Transfection Agent to Direct Macrophage Polarization
C. A. Kraynak*, L. J. Suggs, University of Texas at Austin, Austin, TX

560. Development of a Clinically Relevant Rabbit Surgical Model for Investigation of the Host Response to Polypropylene Mesh for Pelvic Organ Prolapse
A. Iftikhar*, B. Brown, University of Pittsburgh, Pittsburgh, PA

561. Gene Expression of Macrophage Phenotype Profile Regulated by Different Matrices
M. Sandor, L. Huang, E. Stec, H. Xu, LifeCell, Bridgewater, NJ

562. Immunomodulatory Effect of Amino Acid Based Polyurethanes
M. E. González-Rendón*1, S. N. Davila-Arazazú1, M. Ramírez-Saldaña1, J. V. Cauich-rodríguez2, J. M. Cervantes-Úc2, A. D. Maldonado-Arce1, L. H. Chan-Chan1, 1Universidad de Sonora, Hermosillo, Mexico, 2Centro de Investigación Científica de Yucatán, Mérida, Mexico

Modulating Immune Microenvironments using Biomaterials

563. Lymph Node Stiffness Mimicking Hydrogels Regulate Human B Cell Lymphoma Growth and Cell Surface Receptor Expression in a Molecular Subtype-Specific Manner
F. Apoorva1, Y. Tian1, T. Pierpont1, D. Bassen1, L. Cerchietti2, J. Butcher1, R. Weiss1, A. Singh*1, 1Cornell University, Ithaca, NY, 2Weill Cornell Medical College, New York, NY

564. Immuno-Nanotherapeutics to Improve the Tumor Microenvironment in Non-Small Cell Lung Cancers
D. Seshadri*1, A. Shao1, A. Ramamurthi2, 1Case Western Reserve University, Cleveland, OH, 2Cleveland Clinic Lerner Research Institute, Cleveland, OH

565. Cross-Talk Between Smooth Muscle Cells and Monocytes on Cobalt Chromium Alloy
J. Anderson*, S. Lamichhane, D. Engebretson, T. Vierhout, University of South Dakota, Sioux Falls, SD

566. Immune Response of Chitosan Nanoparticles Functionalized with Different Proteins in Human Whole Blood
Y. Zhang*, W. Du, Department of Polymer Science and Engineering, Hangzhou, China

567. In Vivo Effect of Locally-Delivered Resolvin D1 on Cytokine Production and Macrophage Activation
K. Alkhatib*, A. Diaz-Perez, T. M. Poseno, J. M. Durdik, J. A. Stenken, University of Arkansas, Fayetteville, AR

568. Lymph Node Targeting Nanoparticle Vaccine Delivery Platform for Malaria Transmission Blocking Vaccines
G. P. Howard*1, G. Verma2, X. Ke1, R. Dinglasan2, H.-Q. Mao1, 1Johns Hopkins University, Baltimore, MD, 2University of Florida, Gainesville, FL

569. Dynamic Matrix Stiffening Reduces Macrophage Ability to Polarize to an Inflammatory Phenotype
S. C. Allen*1, A. Hernandez2, A. Antequera1, L. J. Suggs1, 1The University of Texas at Austin, Austin, TX, 2The University of Miami, Coral Gables, FL

570. Modular, Integrin Ligand-Specific Immune Organoids Differentially Regulate Ex Vivo B Cell Activation
S. B. Shah*1, A. Purwada1, W. Beguelin2, T. T. Jing1, A. M. Melnick2, A. Singh1, 1Cornell University, Ithaca, NY, 2Weill Cornell Medical College, New York, NY

571. Gut Microbiome and Associated Systemic Inflammation Regulates Trafficking of Engineered Nanovaccines
M. J. Mosquera*, F. Apoorva, K. Lastra, J. D. Guss, T. Jing, M. Luna, C. J. Hernandez, A. Singh, Cornell University, Ithaca, NY

572. Free Radical Modulating Nanoparticles Induce Innate Immune Response.
A. Patel, J. Kosanovich, S. Balmuri, H. Krishnan, K. M. Empey, S. Sant*, University of Pittsburgh, Pittsburgh, PA

Technology Development/New Biomaterials for Immune Engineering

573. Impact of Molecular Weight on the Intrinsic Immunogenicity of Rapidly-degradable Polymeric Carriers
C. M. Jewell*, J. I. Andorko, University of Maryland, College Park, MD

574. SynergisticalSynergistically Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Blockade of PD1 and IDO
Y. Ye*1, J. Wang1, Q. Hu1, G. M. Hochu2, C. Wang1, Z. Gu1, 1University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, Raleigh, NC, 2North Carolina State University,, Raleigh, NC

575. Synthetic Multivalent Nanobodies for Myeloid Derived Suppressor Cell Depletion in Cancer Immunotherapy
J. Liu*, P. Pradhan, R. Toy, K. Roy, Georgia Institute of Technology, Atlanta, GA

576. Sublingual Administration of Adjuvanted Peptide or Peptide Nanofibers Elicits Antigen-Specific CD4 T Cells
S. H. Kelly*, J. H. Collier, Duke University, Durham, NC

577. Enhanced Tumor Immunotherapy Mediated by Nanoellispoidal Artificial Antigen Presenting Cells
R. A. Meyer*, J. W. Hickey, A. K. Kosmides, K. R. Rhodes, J. C. Sunshine, K. Perica, J. P. Schneck, J. J. Green, Johns Hopkins University, Baltimore, MD

578. Novel Poly (ethylene glycol) Hydrogel with Spatially Controlled Degradation Promotes Ovarian Endocrine Function in Mice
J. R. Day*1, A. David1, J. Kim1, A. L. Cichon1, E. Farkash1, N. Milasinovic2, A. Shikanov1, 1University of Michigan, Ann Arbor, MI, 2University of Belgrade, The Academy of Criminalistic and Police Studies, Belgrade, Serbia

579. Synthetic Poly (ethylene glycol)-Vinyl Sulfone and TheraCyte Immunoisolates Allogeneic Ovarian Tissue and Restores Endocrine Function in Ovariectomized Mice
A. David*, J. R. Day, A. Cichon, A. Lefferts, M. Cascalho, A. Shikanov, University of Michigan, Ann Arbor, MI

580. A Novel “Anti-vaccine” for the Treatment of Collagen-Induced Arthritis
R. P. Allen*, J. Ma, J. S. Lewis, UC Davis, Davis, CA

Surface Characterization and Modification SIG

581. - Withdrawn

582. Surface Modified Silicone Hydrogels via Densely Grafted 2-Methacryloyloxyethyl Phosphorylcholine Polymers
A. Spadafora*, M. Korogiannaki, H. Sheardown, McMaster University, Hamilton, ON

583. Functionalization of Bovine Pericardium with Carbon Dioxide Cold Plasma
D. R. Baltazar, R. Gelamo, L. B. Rocha*, Triângulo Mineiro Federal University, Uberaba, Brazil

584. Adsorbing Glycocalyx-Inspired Dense Glycosaminoglycan Brushes: Towards Improved Blood-Compatibility
M. Kipper, Colorado State University, Fort Collins, CO

585. - Withdrawn

Dental/Craniofacial Biomaterials SIG

586. Membrane Enriched with Graphene for Guided Bone Regeneration Strongly Improve Osteogenic Commitment of Gingival Derived Stem Cells and Support the Regeneration
a. piattelli, University “G. d'Annunzio”, Via Dei Vestini 31, 66100 Chieti, Italy, chieti, Italy

587. Nanometric Hydroxyapatite Covered Implant Surface Evaluated by Bone Regeneration Related Gene Expression. In Vivo Study in Healthy and Diabetic Rats
S. L. S. Souza*, P. G. P. Oliveira, D. M. Reino, F. A. Santos, A. B. Novaes, M. R. Messora, F. B. Bezerra, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil

588. Novel FIR Type of Bioceramics (A Material of Emitting High Performance FAR-Infrared Ray Irradiation) – Potentiality for using as Bone Tissue Scaffold in Dentistry
A. Stamatoski1, J. Fidoski*2, 1The Saints Cyril and Methodius University of Skopje, Skopje, FYRO Macedonia, Tetovo, The former Yugoslav Republic of Macedonia, 2The Saints Cyril and Methodius University of Skopje, Skopje, FYRO Macedonia., Skopje, The former Yugoslav Republic of Macedonia

589. A Comparative Study on the use of Tilapia Collagen Membranes for Guided Bone Regeneration
C. S. Lau*1, A. M. Hassanbhai1, F. Wen1, P. Jayaraman1, D. Wang1, N. Yu2, S. H. Teoh1, 1Nanyang Technological University, Singapore, Singapore, 2National Dental Centre Singapore, Singapore

590. Finite Element Methods for Biomechanical Simulation of Temporomandibular Prosthesis
Y. L. Rodrigues*1, J. R. B. Jesus2, J. C. M. Souza2, B. P. C. Henriques2, J. S. P. Silva1, 1Federal University of Rio Grande do Norte, Natal, Brazil, 2Federal University of Santa Catarina, Florianópolis, Brazil

591. Newly Developed FIR Bioceramics-Based Root Canal Sealers (A Material of Emitting High Performance FAR-Infrared Ray Irradiation) – In Vivo Study on the Biocompatibility
J. Fidoski*, The Saints Cyril and Methodius University of Skopje, Skopje, FYRO Macedonia, Skopje, The former Yugoslav Republic of Macedonia

592. New Calcium Phosphate Bioceramic for Bone Regeneration: A Study in Rabbit Critical-Sized Calvarial Defects.
F. Guastaldi*2, E. Filho1, É. Marcantonio-Junior2, J. Cirelli2, A. Guastaldi1, 1Institute of Chemistry of Araraquara, São Paulo State University, Araraquara, Brazil, 2Araraquara Dental School, São Paulo State University, Araraquara, Brazil

593. Finite Element Methods for Biomechanical Simulation of Temporomandibular Prosthesis
Y. L. Rodrigues*1, J. C. M. Souza2, B. A. P. Henriques2, J. S. P. Silva1, J. R. B. Jesus2, 1Federal University of Rio Grande do Norte, Natal, Brazil, 2Federal University of Santa Catarina, Florianópolis, Brazil

594. Quality of Osteointegration Surrounding Dental Implants Affected by Surface Modification: a Nanoindentation Study
R. C. Doud*, R. Abou-Arraj, A. Eberhardt, University of Alabama at Birmingham, Birmingham, AL

595. Effect of Gelling Agent’s Viscosity on the Tear Strength of Irreversible Hydrocolloid Dental Impression Materials
V. Şahin*1, H. Jodati2, Z. Evis3, 1Kırıkkale University, Kırıkkale, Turkey, 2Middle East Technical University, Ankara, Turkey

Engineering Cells and Their Microenvironments SIG

Biomaterials with Dynamic Properties

596. In Vitro Effects of Short Term Magnetic Stimulation and Nanoparticle Loading on Mesenchymal Stem Cell Behavior
A. A. Adedoyin*, A. K. Ekenseair, Northeastern University, Boston, MA

597. Permeability, Mechanical Strength and Magnetic Properties of Magnetic Bacterial Nanocellulose Composites
A. Shetty, J. P. Allain, S. L. Arias*, University of Illinois at Urbana-Champaign, Urbana, IL

598. In vitro Mechanical Properties of High Glycolide Content Monofilaments
V. Rodriguez-Rivera*, S. D. McCullen, M. S. Taylor, Poly-Med, Incorporated, Anderson, SC

599. The Effects of Ultrasound Stimulation on Platelet-like-particle Mediated Matrix Deformation
S. Nandi*1, A. Joshi2, M. Muller2, A. C. Brown1, 1The University of North Carolina - Chapel Hill/North Carolina State University, Comparative Medicine Institute, North Carolina State University, Raleigh, NC, 2North Carolina State University, Raleigh, NC

600. Guided Osteogenic Differentiation of Mesenchymal Stem Cells Via Tuning Mineralized Scaffold Architecture on the Basis of Porosity and Surface Roughness
J. L. Harding, M. D. Krebs*, Colorado School of Mines, Golden, CO

601. Nanoscale Drug Release Vehicles for Targeting Kinase Pathways in Tumor Cells
J. Dorilio*, N. Cutrone, S. Hurley, H. Pajovich, A. Smith, I. Banerjee, Fordham University, Bronx, NY

602. Temporal regulation of hydrogel stiffness through orthogonal enzymatic reactions
M. Arkenberg*, J. Bragg, C-C. Lin, Indiana University Purdue University Indianapolis, Indianapolis, IN

603. Chemical and Structural Analysis of Osseous Tissue within Synthetic Intervertebral Spinal Spacers
G. Pezzotti1, N. Oba1, W. Zhu2, E. Marin1, A. Rondinella1, F. Boschetto1, K. Yamamoto3, B. McEntire*4, BS. Bal5, 1Kyoto Institute of Technology, Kyoto, Japan, 2Osaka University, Osaka, Japan, 3Tokyo Medical University, Tokyo, Japan, 4Amedica Corporation, Salt Lake City, UT, 5University of Missouri Health Care, Columbia, MO

604. - Withdrawn

Cancer Nanotechnology

605. The Combination of BIBF 1120 (BIBF) and Paclitaxel (PTX) Independently Loaded in PLGA Nanoparticles as a Treatment for Endometrial Cancer (EC)
K. Ebeid*1, X. Meng1, A.-V. Do1, A. Wongrakpanich2, S. Geary1, K. Thiel1, K. Leslie1, A. K. Salem1, 1University of Iowa, Iowa City, IA, 2Mahidol University, Bangkok, Thailand

606. Nanobody-Conjugated, Quantum Dot-Based Unimolecular Micelles for Targeted Triple Negative Breast Cancer Therapy
Y. Wang1, Y. Wang1, G. Chen1, Y. Li2, W. Xu1, S. Gong*1, 1University of Wisconsin-Madison, Madison, WI, 2Tsinghua University, Madison, WI

607. Photo-triggered N2-Generating Submicroparticles for Cancer Cell Killing
W. Tong*, H. Li, W. Zhang, N. He, C. Gao, Zhejiang University, Hangzhou, China

608. AuNR@mSiO2@Au Theranostics for Cancer SERS Detection and Combined Therapy
Q. Guan*, M. Wang, The University of Hong Kong, Hong Kong, Hong Kong

609. pH-sensitive oxidative stress-inducing polysaccharide nanoparticles as anticancer therapeutics
E. Hong*, Y. Go, D. Yoo, J. Lee, D. Lee, Chonbuk National University, Jeonju, Republic of Korea

610. - Withdrawn

611. Electrodeposited Magnetic Nanowires Show Potential as Magnetic Resonance Imaging Contrast and Magnetic Hyperthermia Particles
S. L. Pailloux1, J. Zhang2, T. Gage2, D. J. Flannigan2, M. Garwood2, J. Bischof2, V. C. Pierre2, B. J. H. Stadler2, 1University of Minnesota, Twin Cities, Minneapolis, MN, 2University of Minnesota, Minneapolis, MN

612. Bifunctional Gold Nanoparticle for Tracking Cancer and Treatment by Photothermal Therapy
K. S. Dhada*, L. J. Suggs, University of Texas at Austin, Austin, TX

613. Optical Surveillance of Multi-organ Metastases via Rare Earth Albumin Nanocomposites as Cancer Theranostics
H. Kantamneni*1, M. Zevon1, L. Higgins1, D. Adler1, Y. Sheng2, X. Zhao2, R. E. Riman1, M.-C. Tan2, M. Pierce1, C. M. Roth1, V. Ganapathy1, P. V. Moghe1, 1Rutgers University, Piscataway, NJ, 2Singapore University of Technology and Design, Singapore, Singapore

614. Binding Kinetics and Isotherm of Immunotargeted Au NPs for HER2+ Breast Cancer Cells
T. Vargo-Gogola1, R. K. Roeder2, 1Indiana University School of Medicine - South Bend, South Bend, IN, 2University of Notre Dame, Notre Dame, IN

615. Quantitative Molecular Imaging of Breast Microcalcifications using Targeted Gold Nanoparticles and Spectral CT
T. E. Curtis1, T. L. McGinnity1, P. D. Nallathamby1, T. Vargo-Gogola2, R. K. Roeder1, 1University of Notre Dame, Notre Dame, IN, 2Indiana University School of Medicine, South Bend, IN

Cell Migration and Biomaterials

616. Gradient Biomaterials Mediate the Rate and Direction of Cell Migration
C. Gao*, Zhejiang University, Hangzhou, China

617. In vitro 3D Model for Glioblastoma Cell Migration: The Role of Cell-matrix Interaction
Y. Cui*1, S. Cole1, A. Short2, C. Hogan1, J. O. Winter1, 1The Ohio State University, Columbus, OH, 2Battelle Biomedical Research Center, Columbus, OH

618. Engineered Nano-Clay Based 3D Tumor Model as a Test-Bed to evaluate Mesenchymal to Epithelial Transition (MET) in Prostate Cancer Metastasis
M. S. Molla*, D. R. Katti, K. S. Katti, North Dakota State University, Fargo, ND

619. Modulation of the Stiffness Gradient on the Surface of Polyacrylamide Substrate to Regulate the Migration of Osteoblast Precursor Cells
K. Yamamoto*, E. Nakamachi, Y. Morita, Doshisha University, Kyotanabe, Japan

620. Towards the Mechanism of Fibroblast Contact Guidance in Aligned Fiber Networks
A. Nelson*, A. Ellis, S. Johnson, R. Tranquillo, University of Minnesota, Minneapolis, MN

Design, Fabrication and Characterization of Multiscale and Multifunctional Biomaterials

621. Micron/Nano Hierarchical Topography of Titanium Surface Influences Adhesion and Multi-differentiation Behaviours of Mesenchymal Stem Cells
P. Chen1, T. Hanawa*1, T. Aso2, R. Sasaki2, Y. Tsutsumi1, M. Ashida1, H. Doi1, 1Tokyo Medicala nd Dental University, Tokyo, Japan, 2Aisin Seiki Co., Ltd, Kariya, Japan

622. Grid Patterns on Titanium Surface Promote Adhesion and Differentiation of Mesenchymal Stem Cells
P. Chen*1, T. Aso2, R. Sasaki2, Y. Tsutsumi1, M. Ashida1, H. Doi1, T. Hanawa1, 1Tokyo Medical and Dental University, Tokyo, Japan, 2Aisin Seiki Co., Ltd., Aichi, Japan

623. Characteristic Differences Between Water Dialyzed and Buffer Dialyzed Keratose Biomaterial
N. A. Potter*, M. Van Dyke, Virginia Tech, Blacksburg, VA

624. Analysis of Bioactivity and Cytotoxicity in Ca-P coatings with Si and Ag Inclusion Obtained by Plasma Electrolytic Oxidation on Ti6Al4V
S. M. Leal Marin*1, H. Carreño Garcia2, P. Escobar Rivero2, H. A. Estupiñan Duran1, 1Universidad Nacional de Colombia sede Medellin, Medellín, Colombia, 2Universidad Industrial de Santander, Piedecuesta, Colombia

625. Hydrogel Materials Interacting with Polysaccharide Wetting Agents for Contact Lens Application
L. Liu*, N. Shaabana, H. D. Sheardown, McMaster University, Hamilton, ON

626. Near Superhydrophobic Surface Reduces Shear-Induced Red Blood Cell Damage
C. Q. Lai*, Nanyang Technological University, Singapore, Singapore

627. Switchable Polymer Brushes for Controlled Detection of Hepatitis C Virus
S. Demirci*, S. Kinali-Demirci, S. Jiang, Iowa State University, Ames, IA

628. - Withdrawn

629. Tailoring Mechanical Properties and Protein Release of Alginate-Chitosan Polyelectrolyte Complexes
N. A. Fletcher*, E. L. Von Nieda, M. D. Krebs, Colorado School of Mines, Golden, CO

630. Gold Nanorod Core-mesoporous Silica Shell Nanodevice for Caner Targeting, Imaging and Controlled Drug Release
Q. Guan*, M. Wang, The University of Hong Kong, Hong Kong

631. - Withdrawn

632. Polyethylenimine Mediated Synthesis of Gold Nanoparticles for Biomedical Applications
R. J. Narayan, University of North Carolina and North Carolina State University, Raleigh, NC

633. Recombinant human hair keratins for the development of tailored biomaterials
R. N. Parker*, K. L. Roth, A. Trent, M. E. Van Dyke, T. Z. Grove, Virginia Tech, Blacksburg, VA

634. A Mechanistic Evaluation of Intrinsic Crosslinking Properties and Synthesis Procedures for Keratin-based Microparticles
M. Thompson*, Virginia Tech, Blacksburg, VA

635. Computerized Rotational Jet Spraying of Polymers for Biofabrication of Composite Tubular Scaffolds
U. L. Erol*1, M. Younesi1, O. Akkus1, M. Weidenbecher1,2, M. Mofidfar1, G. Wnek1, 1Case Western Reserve University, Cleveland, OH, 2University Hospital Medical Center, Cleveland, OH

636. - Withdrawn

637. Decoupling Bulk Properties from the Cellular Microenvironment
J. L. Lilly, A. Gottipati, C. F. Cahall, M. Agoub, B. Berron*, University of Kentucky, Lexington, KY

638. Improving Gelation Efficiency of Visible Light Polymerized Thiol-Norbornene Hydrogels via Addition of Soluble Tyrosine
H. Shih1, H.-Y. Liu*1, C.-C. Lin1,2, 1Purdue University, Indianapolis, IN, 2Indiana University, Indianapolis, IN

639. - Withdrawn

640. Facile Polymersome Assembly and Loading via Multi-Impingement Flash Nanoprecipitation
S. D. Allen*, O. Osorio, E. A. Scott, Northwestern University, Evanston, IL

641. Effects of Fluoride or Hydrogen Peroxide Gels on the Surface of Titanium Implant Systems
G. M. P. Juanito1, J. K. Schmitz1, M. B. Sordi1, M. A. N. Oliveira1, R. S. Magini1, M. T. Mathew2, J. C. M. Souza*1, 1Federal University of Santa Catarina, Florianópolis, Brazil, 2University of Illinois, Rockford, IL

642. Fluorescent Ultrathin Fibers Containing Water-Soluble Graphene Quantum Dots for Tissue Engineering Applications
B. V. M. Rodrigues, T. S. Cabral, F. R. Marciano, A. O. Lobo*, University of Vale do Paraiba, Sao Jose Campos, Brazil

643. Laminated Poly(ethylene glycol)-protein Fibers Composites Exhibiting Shape Memory Characteristics
X. Zhang*1, Q. Li1, T. Jin2, Y. Bai1, H. Nie3, R. Yang1, 1Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China, 2Rice University, Houston, TX, 3Hunan University, Changsha, China

644. Directed Irradiation Synthesis (DIS) on Dense and Porous Titanium Surface for Enhanced Stem Cell Adhesion and Proliferation
A. R. Shetty*, A. Barnwell, S. Arias, J. P. Allain, University of Illinois at Urbana Champaign, Urbana, IL

645. Fabrication of Polyethylene Glycol-Based Templated Macroporous Hydrogels
M. Imaninezhad*, G. Kolar, S. P. Zustiak, Saint Louis University, Saint Louis, MO

646. Electrospinning and Characterization of Low Friction Zwitterionic Polyurethane Fibermat Composites
A. O. Osaheni*1, K. A. O'Connor1, M. M. Blum1, P. T. Mather2, 1Syracuse University, Syracuse, NY, 2Bucknell University, Lewisburg, PA

647. Influence of Alginate Calcium on the Phase Transformation and Crystal Structure of Calcium Phosphate
Y. Xiao*, X. Zhang, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, Chengdu, China

648. Morphological, Electrical and Mechanical Characterization of Neonatal Cardiomyocytes Cultured on Wrinkled PDMS
Z. Wang1, C. Yuan1, A. Wei1, T. K. Borg2, B. Z. Gao*1, 1Clemson University, Clemson, SC, 2Medical University of South Carolina, Charleston,, SC

649. Tailoring the Physical Properties of a Polydioxanone Yarn with Potential to Improve Soft Tissue Repair
R. E. Abhari*, P.-A. Mouthuy, C. Brown, A. Carr, University of Oxford, Oxford, United Kingdom

650. - Withdrawn

651. Highly Elastic PVA-Gelatin Hydrogels for Elastic Soft Tissue Engineering
P. N. Charron*, R. A. Oldinski, University of Vermont, Burlington, VT

652. Ti-Dioxide Nanotubes with Superior Hydrophilicity for Hard Tissue Implants
D. Osinloye*, University of Illinois at Chicago, Chicago, IL

653. Layer by Layer Assembly of Nanoscaffolds for Neural Tissue Regeneration
A. Smith*, H. Pajovich, N. Cutrone, I. Banerjee, Fordham University, Bronx, NY

654. Polymer Infiltration Toughened Hydroxyapatite Biomaterial Hybrids by Bio-inspired Materials Design
R. Khanna*, A. Ngunza, X. Wang, The University of Texas at San Antonio, San Antonio, TX

655. Microfluidic generation of photoresponsive droplets enable the formation of multiple microparticle geometries.
SC. Lesher-Perez*, Y. Zhang, T. Segura, University of California, Los Angeles, CA

Emerging Applications in Engineering Cells and Their Microenvironments

656. Immobilization of nucleic acid aptamers on macrophages for the capture of tumor cells
Y. Iwasaki*1, S. Sugimoto2, T. Mori3, 1Kansai University, Suita, Osaka, Japan, 2Kansai University, Suita, Japan, 3Kyushu University, Fukuoka, Japan

657. Using a Novel Semi-Automated Approach for Measuring an Array of Cell Shape Descriptors: Effect of 2D and 3D Fibrin Scaffolds over Time on Mesenchymal Stromal Cell Morphology
M. L. Hart*1, K. Wörgötter2, C. Gehse2, B. Rolauffs1, 1University of Freiburg, Freiburg, Germany, 2University of Tuebingen, Tuebingen, Germany

658. The Use of a Suspended Carbon Fiber Culture to Model Myelination by Human Schwann Cells
A. Merolli*, Y. Mao, J. Kohn, Rutgers - The State University of New Jersey, Piscataway, NJ

659. Subcutaneous Transplantation of Reconstituted Pseudo-Islets in Diabetic SCID/bg Mice
A. E. Vlahos*, S. Keshavjee, A. Martyts, M. V. Sefton, University of Toronto, Toronto, ON

660. Interactions of Platelets with Endothelial and Smooth Muscle Cells Co-Cultured on Cobalt Chromium Surfaces: An In Vitro Post-Implant Model
T. Vierhout*1, J. Anderson1, M. Larson2, D. Engebretson1, S. Lamichhane1, 1University of South Dakota, Sioux Falls, SD, 2Augustana College, Sioux Falls, SD

661. - Withdrawn

662. Multipotent Adult Progenitor Class Cells Encapsulated in Alginate Hydrogels Retain Viability and Upregulate Angiogenic and Immunogenic Cytokine Production
J. Bossert*, A. LoGuidice, RTI Surgical, Alachua, FL

663. Ovarian-specific Hydrogels for Follicle Development and Fertility Preservation
M. J. Buckenmeyer*1, Y. Ren2, A. Rajkovic2, B. N. Brown1, 1University of Pittsburgh, Pittsburgh, PA, 2Magee-Womens Research Institute, Pittsburgh, PA

664. Monitoring Spatiotemporal Proteolytic Activitiy in Tumor Microenvironments with Fluorogenic Microgel Sensors
D. Shin*, E. Y. Tokuda, C. E. Miksch, K. S. Anseth, University of Colorado, Boulder, CO

665. Ascorbic Acid and Tunable Mechanics of Silk Scaffolds Maintain Tissue Cell Niche
J. J. Pearson*, P. Dowell, K. Sanchez, J. L. Ong, T. Guda, University of Texas at San Antonio, San Antonio, TX

666. Collagen Alignment Alters Vascular Network Morphology and Pro-Angiogenic Factor Secretion
M. G. McCoy*, J. Wei, L. Yang, C. Fischbach, Cornell University, Ithaca, NY

667. Conditioning Cells to the Compliance of the Soft Underlying Substrate
S. Syed*1, A. Blanco1, S. Zustiak1, J. Schober2, 1Saint Louis University, Saint Louis, MO, 2Southern Illinois University, Edwardsville, Edwardsville, IL

668. Hydrogel-based in vitro Glioblastoma Spheroid Models
L. Hill*, A. Ashraf, S. P. Zustiak, Saint Louis University, St. Louis, MO

669. Tissue Engineered bone-mimetic 3D in vitro model to study breast cancer bone metastasis
S. Kar*, D. R. Katti, K. S. Katti, North Dakota State University, Fargo, ND

670. Hydrogels to Study Vasculogenesis in Hypoxic Microenvironments
M. R. Blatchley*1, S. Wang1, F. Hall2, S. Gerecht1, 1Johns Hopkins University, Baltimore, MD, 2Mississippi State University, Starkville, MS

Engineered Biomaterials for Neural Applications

671. Nanofiber Based Materials for Neural Interfacing
L. Costella*1, K. Mangham1, M. Skoff1, K. Yoshida2, C. Tison1, 1Luna Innovations Incorporated, Charlottesville, VA, 2Indiana University - Purdue University Indianapolis, Indianapolis, IN

672. Cerebral Decellularized Extracellular Matrix as In Vitro Model for Neural Development
R. A. Gittens*, D. Reginensi, S. Valerio, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama

673. Developing Mussel Adhesive Protein-based Nerve Conduit to Accelerate Nerve Regeneration
H. Cheong*1, J. Kim2, J.-I. Lee2, E. J. Kim2, B. J. Kim1, J.-W. Rhie2, H. J. Cha1, 1POSTECH, Pohang, Republic of Korea, 2Seoul St. Mary’s Hospital, Seoul, Republic of Korea

674. In vitro and in vivo Evaluation of Different Gellan Gum Formulations for Peripheral Nerve Regeneration
C. R. Carvalho*1, S. Wrobel2, C. Meyer3, C. Brandenberger4, R. López-Cebral1, J. Silva-Correia1, G. Ronchic5, R. Reis1, C. Grothe3, J. M. Oliveira1, K. Haastert-Talini3, 13B’s Research Group, Guimarães, Portugal, 2Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany, 3Institute of Neuroanatomy, Hannover Medical School, Hannover, Germany, 4Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany, 5Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Torino, Italy

675. Region-specific Laminin-functionalized Hydrogels for Delivery of Neural Stem/progenitor Cells
D. Barros*, J. Furtado, F. Ferreira-da-Silva, I. F. Amaral, A. P. Pêgo, i3S - Instituto de Investigação e Inovação em Saúde, Porto, Portugal

676. The Effect of Topography and Tethered-peptide on Embryonic Stem Cell Neural Differentiation
E. Silantyeva, J. Carpenter, W. Nasir, M. L. Becker, R. K. Willits*, The University of Akron, Akron, OH

677. Crosslinked Hyaluronan-based Hydrogels for Glioma Neural Stem Cell Culture
L. J. Smith*, R. Y. Tam, A. E. G. Baker, P. B. Dirks, M. S. Shoichet, University of Toronto, Toronto, ON

678. Balancing Cell Removal and Preservation of Intricate ECM Microstructures during Chemical Decellularization of Peripheral Nerve
M. W. Mertz*, N. E. Vaughn, R. A. Wachs, C. E. Schmidt, University of Florida, Gainesville, FL

679. Electrically Conductive Hydrogel with Positively Charged Surfaces for Nerve Tissue Engineering
X. Liu*, M. J. Yaszemski, L. Lu, Mayo Clinic, Rochester, MN

680. Using Interpenetrating Networks to Study the Relative Effects of Substrate Stiffness on Neural Phenotype Modulation in 2D and 3D Microenvironments
D. J. Munoz-Pinto*1, R. Tchen1, R. Zurita1, Z. Nickle2, A. C. Jimenez-Vergara1, 1Trinity University, San Antonio, TX, 2McGill University, Montreal, QC

681. Carbon Nanotubes-Hydrogel Composites for Neural Tissue Engineering Applications
M. Imaninezhad*, I. Kuljanishvili, F. Xu, G. Kolar, S. P. Zustiak, Saint Louis University, Saint Louis, MO

682. Polyanhydride-based Nanomedicine Platform for Combating Neurodegeneration
B. W. Schlichtmann*, S. Ghaisas, V. Anantharam, A. Kanthasamy, S. Mallapragada, B. Narasimhan, Iowa State University, Ames, IA

683. Injectable chitosan-PEG Based Hydrogels for Spinal Cord Local Delivery in Syringomyelia Models
A. E. Mohrman, M. Farrag*, N. D. Leipzig, University of Akron, Akron, OH

684. Modulating Neuroinflammation with Porous Templated Scaffolds
I. Dryg*, Z. Khaing, L. Zhen, D. DeWees, L. Cates, J. Bryers, B. Ratner, C. Hofstetter, University of Washington, Seattle, WA

685. Development of a Semi-Interpenetrating Network Hydrogel to Study the Effects of Mild Traumatic Brain Injury on Astrocyte Remodeling
N. M. Sturdivant*1, A. Walker1, Y. Zhang1, A. Ederle1, N. Lam1, J. Wolchok1, H. Rosas-Hernandez2, E. Cuevas2, S. F. Ali2, K. Balachandran1, 1University of Arkansas, Fayetteville, AR, 2National Center for Toxicological Research, Jefferson, AR

686. Functionalized Rosette Nanotubes Alter Peripheral Neuron Morphology
M. Puzan, B. Legesse, R. Koppes, H. Fenniri, A. Koppes*, Northeastern University, Boston, MA

687. - Withdrawn

688. Engineered Nerve-Regeneration in Disruptive Brachial Plexus Lesions: An in-vivo Pilot Study
E. Sanna Passino1, A. Merolli*2, Y. Mao2, J. Kohn2, ML. Manunta1, 1Universita di Sassari, Italy, 2Rutgers - The State University of New Jersey, Piscataway, NJ

689. BDNF-Mimetic Peptide Amphiphiles for Neural Regeneration
A. Edelbrock*, Z. Alvarez-Pinto, S. Stupp, Northwestern University, Chicago, IL

690. Magnetically Oriented Collagen Hydrogels for Directing and Differentiating Neural growth
M. Antamn-Passig*, O. Shefi, Univ. Bar-Ilan, Ramat-Gan, Israel

Engineering Cells and Their Microenvironments

691. Enrichment of Patient Derived Glioblastoma Stem Cells in Three-Dimensional PNIPAAm Scaffolds
J. Heffernan*1, J. McNamara2, S. Borwege1, B. Vernon3, N. Sanai1, S. Mehta1, R. W. Sirianni1, 1Barrow Neurological Institute, Phoenix, AZ, 2University of Arizona, Tucson, AZ, 3Arizona State University, Tempe, AZ

692. - Withdrawn

693. Modulating Primary Human Hepatocyte Functions via Growth Factor Delivery from Chitosan-Heparin Polyelectrolyte Multilayers
S. R. Khetani*1, C. Lin1, K. Ballinger2, L. Place2, M. Kipper2, 1University of Illinois at Chicago, Chicago, IL, 2Colorado State University, Fort Collins, CO

694. Mechanical and Morphological Analysis of Cancer Cells on Nanostructured Substrates
L. Zheng, Northeastern University, Boston, MA

Multifunctional Biomaterial Design for Regenerative Tissue Engineering

695. TGF-b1 Conjugated and Collagen Impregnated Chitosan Hydrogels Enhance Chondrogenic Differentiation of Human Mesenchymal Stem Cells
J. Kim*1, B. Lin2, S. Kim2, B. Choi2, 1Hongik University, Sejong, Republic of Korea, 2UCLA, Los Angeles, CA

696. Functionalized Nanofibrous Scaffold for Endogenous Bone Regeneration
Q. Yao*, Y. Liu, S. Hongli, University of South Dakota, Sioux Falls, SD

697. Multi-responsive Biomaterials Based on Multiwalled Carbon Nanotubes, Graphene Oxide and Polymeric Ultrathin Fibers
B. V. M. Rodrigues, C. A. Razzino, F. R. Marciano, A. O. Lobo*, University of Vale do Paraiba, Sao Jose Campos, Brazil

698. Anti-inflammatory Effects of PEG-bis-AA/HA-DXM hydrogel in Rat Traumatic Brain Injury
D. U. Jeong*1, S. Bae1, C. Macks1, J. Whitaker1, K. Webb1, M. Lynn2, J. S. Lee1, 1Clemson University, Clemson, SC, 2Greenville Health System, Greenville, SC

699. Microstructure and Mechanics of Polycaprolactone based Polyurethane Microgels
Y. Yuan*, D. Sarkar, University at Buffalo, The State University of New York, Buffalo, NY

700. Chondrogenic-Inductive Nanofibrous Substrates Biofunctionalized with Immobilized Autologous TGF-b3 and IGF-I
M. Casanova*, M. Alves da Silva, A. R. Costa-Pinto, R. L. Reis, A. Martins, N. M. Neves, University of Minho, Guimarães, Portugal

701. Composite-mediated Angiogenesis to Enhance the Survival of Transplanted Human Adipose Stem Cells
X. Li*, B. Cho, M. Seu, R. Martin, G. Walia, M. Callanan, S. Reddy, J. Sacks, H-Q. Mao, Johns Hopkins University, Baltimore, MD

Printing and Patterning of Cell Microenvironments

702. 3D Printing Induces Polymer Fiber Alignment and Cell Organization
T. Guo*, J. P. Ringel, J. P. Fisher, University of Maryland, College Park, MD

703. Fabrication of Concomitant Neutral and Acidic Local pH Multi-Arrays Mimicking Native and Cancer Microenvironments by Layer-by-Layer Inkjet Printing
Y. Shioji*, M. Matsusaki, Osaka Univ., Osaka, Japan

704. Manipulating the Orientation of Cardiac Cells and Vascular Network by using Thermo-responsive Polymer Gel and 3D Printing System
Y. Tsukamoto*, F. Shima, M. Akashi, Osaka University, Suita, Japan

705. Development of Growth Factor Based Nano Film through Ink-jet Printing
M. Choi*, D. Choi, U. Han, J. Hong, Chung-Ang University, Seoul, Republic of Korea

706. Two Photon Laser Micro-processing of Gelatin Methacrylate
Z. Xiong*, J. Yan, J. R. O. Collins, R. Ramos, P. Soman, Syracuse University, Syracuse, NY

707. 3D Printing of Colloidal Building Blocks for Modular Tissue Engineering
J. Nortey*1, D. Chester2, T. Ngobili2, M. Daniele2, A. Brown2, 1North Carolina State University, Gastonia, NC, 2North Carolina State University, Raleigh, NC

708. Spatially Controlled Photo-Patterning of Multi-Material Bioactive Hydrogels
B. Grigoryan*, P. Greenfield, A. Zaita, A. Ta, J. Miller, Rice University, Houston, TX

Drug Delivery SIG

Biomaterials for Therapeutic Drug Delivery

709. Electrospun Chitosan for Oral Insulin Delivery
M. G. Lancina*1, R. K. Shankar2, H. Yang1, 1Virginia Commonwealth University, Richmond, VA, 2Children's Hospital of Richmond at VCU, Richmond, VA

710. STUDENT AWARD FOR OUTSTANDING RESEARCH: Development and Characterization of Stimuli-Responsive Hydrogel Microcarriers for Oral Protein Delivery
C. E. O'Connor*, S. D. Steichen, N. A. Peppas, The University of Texas at Austin, Austin, TX

711. Supramolecular Assemblies of Alkane Functionalized Poly ethylene glycol Copolymer for Drug Delivery
L. Zhu*, Iowa State University, Ames, IA

712. Smart Heparin Transcutaneous Patch
Y. Zhang*1, J. Yu1, J. Wang1, N. Hanne1, Z. Cui2, C. Qiang1, C. Wang1, H. Xin1, J. Cole1, C. Gallippi1, Y. Zhu1, Z. Gu1, 1University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 2North Carolina State University, Raleigh, NC

713. Development of a Novel Topical Controlled Release System for Otic Drug Delivery
L. Bruk*, N. Myers, C. Alper, M. Fedorchak, University of Pittsburgh, Pittsburgh, PA

714. Lysozyme-triggered increase in the release rate of dextran from oligomer-crosslinked alginate
D'A. T. Turner, L. A. Wells*, Queen's University, Kingston, ON

715. Drug Loaded Poly(glycerol carbonate) Films and Meshes for the Prevention of Lung Tumor Recurrence Following Surgical Resection
M. Grinstaff*, Boston University, Boston, MA

716. Effects of Solvents in Fabrication Methods of PLGA-based Ultrasound Contrast Agents: A Comparative Analysis
T. U. Rehman*, N. Yonet-tanyeri, Istanbul Medipol University, Istanbul, Turkey

717. Controlled and Localized Drug Delivery Platforms Based on Mussel Adhesive Protein Nanoparticles for Cancer Therapy
Y. Jeong*, Y. K. Jo, H. J. Cha, Pohang University of Science and Technology, Pohang, Republic of Korea

718. Exploring Pressurised Gyration and Electrohydrodynamic Atomisation Methods for Producing Drug-loaded Mucoadhesive fibres
F. A. Brako*, M. Crabbe-Mann, M. Parhizka, D. Craig, M. Edirisinghe, University College London, London, United Kingdom

719. Developing a Dopant-free Polyester based Photoluminescent Hydrogel
X. Xu*, Y.-H. Tsou, New Jersey Institute of Technology, Newark, NJ

720. Nonaqueous Semi-Solid Nanocomposites for Synergistic Delivery of Combination Drugs
M. Brabender*, A. Tabet, S. Hanson, D. Sprouse, V. Tran, S. Egger, C. Wang, University of Minnesota, Minneapolis, MN

721. Recruitment of the Autophagic Machinery by the Acid-labile Polyrotaxanes Exerting Intracellular Release of Methylated β-cyclodextrins
K. Nishida*, A. Tamura, N. Yui, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Japan

722. Novel Biodevice Reduces Cellular Genotoxicity of an in vitro Oxidative Stress Model of Alzheimer’s Disease
G. N. Salles, F. R. Marciano, C. Pacheco-Soares, A. O. Lobo*, University of Vale do Paraiba, Sao Jose Campos, Brazil

723. The Use of Microfluidic Mixing Devices for Minimizing Polyplex Nanoparticle Size and Increasing Tumor Penetration
A. Jackson*1, M. A. Jackson2, C. L. Duvall2, B. C. Evans2, 1Brown University, Springfield Gardens, NY, 2Vanderbilt University, Nashville, TX

724. Meeting the Polypharmacy Challenge: Development of Polymeric Carriers Co-encapsulationing Multiple Drugs Using Electrohydrodynamic Atomization
T. Shams*, M. Parhizkar, U. Illangakoon, M. Orlu-Gul, M. Edirisinghe, University College London, London, United Kingdom

725. Hydrogel Patches on Live Cell Through Surface Mediated Polymerization
J. Lilly, B. Berron, University of kentucky, lexington, KY

726. Effect of Tannic Acid on the Mechanical Properties of Dense Collagen Matrices and Melanoma Cell Proliferation
C. J. Bridgeman, T.-U. Nguyen, M. B. Fenn, V. Kishore*, Florida Institute of Technology, Melbourne, FL

727. In Vitro Evaluation on Effects of Porosity and Pore Size on Chitosan Sponge Characteristics
D. Ahn1, W. O. Haggard2, L. R. Boles*2, 1Vanderbilt University, Nashville, TN, 2University of Memphis, Memphis, TN

728. Adsorption of Nanospheres onto Substrates: Structural Investigations and QCM Studies
S. Murthy*, Z. Zhang, S. Borsadia, J. Kohn, Rutgers University, Piscataway, NJ

729. Continuous Production and Purification of DNA Nanoparticles Using Flash Nanocomplexation and Tangential Flow Filtration
H.-W. Liu*, S. Ng, Y. Ren, H.-Q. Mao, Johns Hopkins University, Baltimore, MD

730. Tunable, Delayed Protein Release from Layered Polyester Microparticles
D. Dutta, C. Fauer, M. Salifu, K. Hickey*, S. E. Stabenfeldt, Arizona State University, Tempe, AZ

731. Aptamer-functionalized Hydrogels for Skin Wound Healing
N. Zhao*1, M. Battig1, M. Xu1, N. Xiong1, G.-H. Fong2, Y. Wang1, 1Pennsylvania State University, State college, PA, 2UConn Health Center, Farmington, CT

732. Tunable Release of Polyglutamate Modified VEGF mimetic Peptides from Bone Grafts Elicits a Progangiogenic Response
N. W. Pensa*, A. S. Curry, S. L. Bellis, University of Alabama at Birmingham, Birmingham, AL

733. Chitosan Paste for Local Antibiotic Delivery: An Assessment of in vitro Antibiotic Elution and Degradation
C. M. Alexander*, W. O. Haggard, J. A. Jennings, University of Memphis, Memphis, TN

734. Release Profile, In Vivo and In Vitro Response to Carbon Monoxide Releasing Molecules Loaded within Electrospun Scaffolds
K. S. Washington, A. V. Patel, N. Abeyrathna, Y. Liao, C. A. Bashur*, Florida Institute of Technology, Melbourne, FL

735. Tunable and Biodegradable PEG Microgels for Temporally Controlled Delivery of Platelet-Rich Plasma
E. Jain*, S. Sheth, S. A. Sell, S. P. Zustiak, Saint Louis University, Saint Louis, MO

736. Soft, Nonresorbable Polymer Composites for Sustained Zero-order Cisplatin Delivery to the Abdomen
A. Mantzavinou*, M. J. Cima, Massachusetts Institute of Technology, Cambridge, MA

737. Development of Tunable Self-Assembled Nanoparticles for Delivery of Small Molecule Therapeutics
A. Sevit*, A. Yu, E. Appel, Stanford University, Stanford, CA

738. Comparing Swelling Ratio of Different PEG-DMA Lengths in Chitosan Drug Loading Matrix
L. R. Pace*1, M. A. Harris2, J. A. Jennings2, 1University of Memphis, Marion, AR, 2University of Memphis, Memphis, TN

739. Metal Ion-Assisted Self-Assembled Complexes for Local Delivery of Minocycline for Spinal Cord Repair
Y. Zhong*1, Z. Wang1, Z. Zhang1, J. Nong1, R. B. Shultz1, V. J. Tom2, R. K. Ponnappan2, 1Drexel University, Philadelphia, PA, 2Drexel University College of Medicine, Philadelphia, PA

740. Electrical Stimulation Based Controlled Drug Delivery from Polypyrrole coated Polyvinylidene fluoride
S. Miar*, T. Guda, University of Texas at San Antonio, San Antonio, TX

741. - Withdrawn

742. Formation of Plant-inspired Polyphenol Complex for an Ocular Drug Delivery
W. Shim*1, H. Lee2, J. Yang3, H. Lee1, 1Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2Inje University Busan Paik Hospital, Busan, Republic of Korea, 3Inje University College of Medicine, Busan, Republic of Korea

743. Modeling the Oxidative Consumption of Curcumin from Controlled Released Poly(beta amino ester) Microparticles in the Presence of Free Radical Generating Systems
C. Jordan*, Z. Hilt, T. Dziubla, University of Kentucky, Lexington, KY

744. Synthesis and Characterization of Polymer Nanogels for the Delivery of Therapeutic Small Molecule Analogs
M. E. Wechsler*, H. R. Culver, N. A. Peppas, The University of Texas at Austin, Austin, TX

745. Release of Amphoteric PABA from Chitosan Scaffolds in Buffered Solution with Electrical Stimulation
J. N. Miller*, B. Sheen, R. C. de Guzman, Hofstra University, Hempstead, NY

746. Transport of Nanomedicine through Blood-brain Barrier
E. Choi, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea

747. Developing Short Peptide based Nanoassemblies as Drug Carriers
N. Cutrone*, J. Dorilio, S. Hurley, H. Pajovich, A. Smith, I. Banerjee, Fordham University, Bronx, NY

748. Food-grade Zein Nanoparticles for Oral Delivery of Epigallocatechin-3-gallate (EGCG)
V. Muthunayagam*1, S. Islam1, F. Eisa1, S. Herrmann2, O. Perumal1, 1South Dakota State University, Brookings, SD, 2Sanford Research, Sioux Falls, SD

749. Localized Biocatalysis via Self-assembled Enzyme-galectin Fusions
S. Farhadi*, G. Hudalla, B. Keselowsky, University of Florida, Gainesville, FL

Device- and implant-based drug delivery

750. Development of a Self-Deploying Drug Release Device
H. Kaji*, T. Kondo, Z. K. Nezhad, J. Suzuki, N. Nagai, T. Abe, Tohoku University, Sendai, Japan

751. Using Ultrasound to Enhance Tumor Cell Killing by anti-PD1 and Doxorubicin-loaded Particles
A.-V. Do*, D. Seol, P. Tobias, J. Martin, A. Salem, The University of Iowa, Iowa City, IA

752. Raspberry Keytone Elution Study for Electrospun Chitosan Membranes of Four Different Treatments
P. Cameron*, H. Su, V. P. Murali, J. D. Bumgardner, University of Memphis, Memphis, TN

753. Effect of Selected Cytokines on Vocal Fold Scar Reduction
H. Chen*, J. Kulwatno, C. Jimenez-Vergara, M. S. Hahn, Rensselaer Polytechnic Institute, Troy, NY

754. A Swellable Drug-eluting Ureteric Stent for the Treatment of Urological Diseases
WS. Lim*1, Y. Huang1, T. Chong2, G. Xiong1, K. Chen2, PS. Er1, S. Venkatraman1, 1Nanyang Technological University, Singapore, 2Singapore General Hospital, Singapore

755. Tubular Nanocarriers with Optimized Dimensions for Sustained Release of Biomolecules
D. Osinloye, T. Shokuhfar*, University of Illinois at Chicago, Chicago, IL

Drug Delivery

756. Synthesis of Poly(ester amide) Microparticles for Intra-articular Drug Delivery
I. J. Villamagna*, University of Western Ontario, London, ON

757. Combination of Rifampin and Ciprofloxacin Exhibit Additive Biofilm Inhibition Capabilities in vitro when Released from Chitosan-based Local Delivery Devices
J. A. Jennings, W. O. Haggard, The University of Memphis, Memphis, TN

758. Next Generation Lipid Nanoparticles for Thermoresponsive Drug Delivery
M. Rehman1, T. J. Webster2, D. Shi2, A. Madni1, A. Ihsan3, 1The Islamia University of Bahawalpur, Bahawalpur, Pakistan, 2Department of Chemical Engineering, Northeastern University, United States, 3National Institute of Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan

759. Controlled Release Microparticles: Response Surface Methodology for Optimization of Hydrophilic and Hydrophobic Drugs
P. M. Kashif, M. Ashfaq, M. Rehman, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

760. Cytosolic Delivery of Doxorubicin to Multidrug Resistant Cancer Cells
J. B. Williams, W. G. Pitt*, C. M. Buchanan, Brigham Young University, Provo, UT

761. In vitro Modeling of Bacteria Biofilm Dynamics
T. J. Spoonmore*1, J. Cassat2, S. Guelcher1, 1Vanderbilt University, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

762. Polydopamine Nanoparticle Size Optimization for Smart Drug Delivery Applications
S. Yaman*, N. Pandey, A. Urias, K. T. Nguyen, The University of Texas at Arlington, Arlington, TX

763. Polyphosphate Loaded Hydrogel Nanoparticles for Suppression of Bacterial Collagenase and Promotion of Intestinal Healing
D. Nichols*1, M. Arron2, O. Zaborina2, J. Alverdy2, F. Teymour1, G. Papavasiliou1, 1Illinois Institute of Technology, Chicago, IL, 2University of Chicago, Chicago, IL

764. Food Grade Protein Biopolymer Based Nanoparticles for Oral Drug Delivery Applications
M. S. ISLAM*, O. Perumal, J. Reineke, R. Kaushik, T. A. Woyengo, South Dakota State University, Brookings, SD

765. A Simple, Self-assembled Hydrogel Depot for Localized Treatment of Large Joint Osteoarthritis
X. He*, N. Sherman, N. Joshi, J. Yan, S. Bhagchandani, K. Slaughter, J. Ermann, J. Karp, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA

Glycomaterials

766. Chemically Tunable Synthetic Glycopolypeptides by NCA Polymerization
J. Kramer*1, M. Zhou2, C. Delaveris2, C. Bertozzi2, 1Stanford University, University of Utah, Stanford, CA, 2Stanford University, Stanford, CA

767. - Withdrawn

768. Bottom-up Hydrogels with Hierarchically Aligned Nanofibers via Glycopeptide Self-assembly
A. Restuccia*, G. A. Hudalla, University of Florida, Gainesville, FL

Injectable Biomaterials for Delivery of Cell, Gene and Protein Therapy

769. Injectable Anisotropic Nanocomposite Hydrogels with Magnetically Aligned Cellulose Nanocrystals
K. De France*, K. Yager, K. J. W. Chan, E. Cranst, T. Hoare, McMaster Unviersity, Hamilton, ON, Canada

770. In Situ Biofunctionalization of Poly(NiPAAm) Hydrogels with Proteins via Epoxide-Mediated Conjugation
M. O. Pehlivaner*1, A. Ekenseair2, 1Northeastern University, Allston, MA, 2Northeastern University, Boston, MA

771. Biodegradable Injectable Polymer Systems Exhibiting Temperature-Responsive Irreversible Covalent Gelation
Y. Ohya*, Y. Yoshida, K. Kawahara, A. Kuzuya, Kansai University, Suita, Japan

772. Coacervated Mussel Protein as an Adhesive Stem Cell Delivery Carrier
T. Y. Park*, H. J. Kim, B.-H. Choi, H. J. Cha, POSTECH, Pohang, Republic of Korea

773. The Potential Role of Fetuin-A Supplementation in Regulating Phenotypic Differentiation in Calcified Vascular Smooth Muscle Cells
J. B. McMahan*, A. M. Kay, J. A. Stewart, C. LS Simpson, Mississippi State University, Mississippi State, MS

774. Nano-silica Incorporation Improves in vitro Osteoblast Response of Injectable Chitosan Microparticles
B. Gaihre*1, C. Jayasuriya2, 1The University of Toledo, Toledo, OH, 2The University of Toledo Medical Center, Toledo, OH

775. An N-isopropylacrylamide Co-Polymer for the Delivery and Temporary Support of Therapeutic Cells in the Retina
M. J. Dodd*1, H. Sheardown2, 1McMaster University, Etobicoke, ON, 2McMaster University, Hamilton, ON

776. Cationic Amphiphilic Polymeric Micelle as Therapeutic siRhoA Carrier for Axonal Regeneration in Spinal Cord Injury
S.-J. Gwak*1, C. Macks1, D. U. Jeong1, K. Webb1, M. Lynn2, M. kindy3, J. S. Lee1, 1Clemson University, Clemson, SC, 2Neurosurgeon, Greenville Health System, Greenville, SC, 3College of Pharmacy, University of South Florida, Tampa, FL

777. Oxidized-Alginate Microbead Encapsulated Osteoclasts as a Cell-based Therapy to Reverse Vascular Calcification
J. L. Colston*1, L. Dunaway2, S. Overholt2, C. LS Simpson2, 1Mississippi State University, Shaw, MS, 2Mississippi State University, Mississippi State, MS

778. Enhanced Cell Viability and In Vivo Degradation of Injectable, Reactive Oxygen Species-Sensitive PEG Hydrogels
J. Martin*, P. Patil, M. Gupta, C. Duvall, Vanderbilt University, Nashville, TN

779. Injectable Cell-Adhesive Polyethylene Glycol Cryogel Scaffolds
J. Bruns*1, S. Zustiak2, 1Saint Louis University, Cincinnati, OH, 2Saint Louis University, St Louis, MO

780. Acetalated Dextran Nanoparticles for Rapid and Glucose Responsive Insulin Delivery
L. R. Volpatti*, R. S. Langer, D. G. Anderson, Massachusetts Institute of Technology, Cambridge, MA

781. Ca-P Bioceramics as Bioactive Support for Human Gingival Mesenchymal Stem Cell Osteogenic Differentiation in vitro
J. F. Vivanco*1, I. Benjumeda1, V. Irribarra, C. Millán, 1Universidad Adolfo Ibáñez, Viña del Mar, Chile,

782. Injectable Gelatin/Oxidized-β-cyclodextrin Hydrogels as Therapeutic Implants and Drug Delivery Vehicles
TT. Hoang Thi, Y. Lee, S. Ryu, K. Park*, Ajou University, Suwon, Korea

783. Galectin 3 as a Retention Strategy for Delivery of Proteins to Multiple Sites In Vivo
S. Freeman*, E. Bracho-Sanchez, K. Koenders, A. Restuccia, M. Fettis, S. Farhadi, G. Hudalla, B. Keselowsky, University of Florida, Gainesville, FL

784. First Trimester Human Umbilical Cord Perivascular Cells Accelerate and Enhance Network Formation of Human Blood Outgrowth Endothelial Cells in 3D Matrigel Environments
Y. Gratch*, P. Szaraz, C. Librach, CReATe Fertility Centre, Toronto, ON

Local Drug Delivery to Cardiovascular Targets

785. Polyethylene Oxide as a Next Generation Platform for Drug-Coated Balloon Application
J. Anderson*1, S. Lamichhane1, D. Engebretson1, K. Pohlson2, A. Wolf2, T. Remund2, P. Kelly2, 1University of South Dakota, Sioux Falls, SD, 2Sanford Research, Sioux Falls, SD

786. Efficacy of Perivascular PLGA Microneedle Meshes for Inhibiting Intimal Hyperplasia in Balloon-injured Rabbit Abdominal Aorta
J. Lee*1, K. J. Lee1, I. H. Seo1, E. H. Jang2, D. H. Kim2, Y.-N. Youn2, WH. Ryu1, 1Yonsei University, Seoul, Republic of Korea, 2Severance Hospital, Yonsei University, Seoul, Republic of Korea

787. Design of Polymer Carriers to Facilitate Cell Uptake and Endosomal Escape of an MK2 Inhibitory Peptide
E. A. Dailing*1, B. C. Evans2, K. V. Kilchrist1, C. L. Duvall1, 1Vanderbilt University, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN

788. Inhibition of Smooth Muscle cells Proliferation Using Sirolimus Loaded, Heparin Bound Polymeric-Micelles
M. LaBerge, JS. Lee, J. V. Betala*, Clemson University, Clemson, SC

Nucleic Acid Delivery

789. A Multifunctional Gene Delivery Nanovector for Cancer Treatment
Q. GUAN*, M. WANG, The University of Hong Kong, Hong Kong, Hong Kong

790. Chemically Modifying of Polyethyleneimine (PEI) to Improve Gene Delivery to Tumor Cells
Y. Huang*, K. Bratlie, Iowa State University, ames, IA

791. Nanoparticle(NP)-mediated siRNA Delivery to Mesenchymal Stem Cells: Effect of NP Composition and Characteristics
D. W. Malcolm*1, Y. Wang1, K. R. Sims2, D. S. W. Benoit1, 1University of Rochester, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Rochester, NY

Targeted Drug Delivery Systems

792. Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy
Q. Hu*1, W. Sun1, H. Bomba2, Z. Gu1, 1University of North Carolina at Chapel Hill, Raleigh, NC, 2North Carolina University, Raleigh, NC

793. New Multifunctional Nanoparticle Platform for Efficient Drug Delivery
K. Miller*, S. Demirci, K. Bratlie, S. Jiang, Iowa State University, Ames, IA

794. Chemotherapeutic Loading Via Tailoring of Drug-Carrier Interactions in Poly(Sialic Acid) Micelles
G. J. Pawlish*1, N. Comolli2, K. Spivak2, A. Gabriel2, 1Temple University, Philadelphia, PA, 2Villanova University, Villanova, PA

795. Penetrating Porous Tissue with Magnetic Targeting
R. Erb*, R. Soheilian, H. Abdi, C. Maloney, K. Delos Reyes, H. Fenniri, Northeastern University, Boston, MA

796. Enzyme-Targeted Nanoparticles for Delivery to Ischemic Muscle
J. L. Ungerleider*, J. K. Kammeyer, B. Pistel, R. L. Braden, N. C. Gianneschi, K. L. Christman, UC San Diego, La Jolla, CA

797. Biodegradable Polymeric Nanoparticles Targeted by a Novel Biomimetic Peptide to Human Breast Cancer
J. Kim*1, E. Bressler2, R. B. Shmueli1, A. Mirando1, N. B. Pandey1, A. S. Popel1, J. J. Green1, 1Johns Hopkins University, Baltimore, MD, 2AsclepiX Therapeutics, LLC, Baltimore, MD

798. Targeted Delivery of p38 MAPK Inhibitors for Multiple Sclerosis Therapy
R. A. Oldinski*, T. Miao, A. Raza, D. Krementsov, University of Vermont, Burlington, VT

799. Design of New Bio-organic Mimics for Drug Delivery Vehicles and an Exploration of their Interactions with Tumor Cells
S. Hurley*, J. Dorilio, N. Cutrone, H. Pajovich, I. Banerjee, Fordham University, Bronx, NY

800. Development of Organic Light-Emitting Diode (OLED) for Biomedical Application
A. Markley*, D. Gil, V. Reukov, Clemson University, Clemson, SC

Tissue Engineering

3D Bioprinting for Medical Applications

801. Comparative Study of 3D Printed Polycaprolactone (PCL)/β- tricalcium Phosphate (β-TCP) and Collagen Membrane as Guided Bone Regeneration in a Beagle Implant Model
J.-Y. Won2, J.-H. Bae1, G. Ahn2, C. Kim2, D.-H. Lim3, D.-W. Cho4, W.-S. Yun5, J.-B. Huh1, J.-H. Shim5, 1Pusan National University, YangSan, Republic of Korea, 2T&R Biofab Co. Ltd, Siheung-Si, Republic of Korea, 3Korea Polytechnic University, Gyeonggi-Do, Republic of Korea, 4POSTECH, Pohang, Republic of Korea, 5Korea Polytechnic University, Siheung-Si, Republic of Korea

802. Generation Of Crimped, Crosslinked Biodegradable Microfibre Scaffolds Via Melt Electrospinning Writing
B. G. Amsden*1, G. Hochleitner2, F. Chen1, P. D. Dalton2, J. Groll2, 1Queen's University, Kingston, ON, 2University of Würzburg, Würzburg, Germany

803. Characterizing Single-Solution, Variable-Property Photopatterned Biocompatible Hydrogel Via Projection Stereolithography
C. I. Fiedler*1, E. A. Aisenbrey1, A. C. Sullivan1, F. DelRio2, S. J. Bryant1, R. R. McLeod1, 1University of Colorado Boulder, Boulder, CO, 2National Institute of Standards and Technology, Boulder, CO

804. Low Cost Bioprinter for Cell Carrying Hydrogels
K. D. Roehm*, S. V. Madihally, Oklahoma State University, Stillwater, OK

805. 3D Robotic Assisted Implantation of Gelatin-Nano-silicate Scaffolds for Critical Sized Bone Defect Osteogenesis and Vascularization.
V. G. Varanasi*1, T. Azimaie1, T. Cebe2, C. Ma1, X. Liu1, P. Aswath3, 1Texas A&M University, Dallas, TX, 2University of Texas at Arlington, Arlington, TX, 3Texas A&M University, Arlington, TX

806. 3D Printed Hormone-Doped Pessaries and IUD's for use in Hormone Replacement Therapy
K. Tappa1, U. Jammalamadaka1, J. Weisman1, S. Alexander2, 1Louisiana Tech University, Ruston, LA, 2LSUHSC-Shreveport, Shreveport, LA

807. Characterization of 3D Printed Constructs for Osteochondral Regenerative Medicine
A. C. Uzcategui*, C. I. Fiedler, A. A. Tomaschke, V. Ferguson, R. R. McLeod, University of Colorado at Boulder, Boulder, CO

808. Proliferation of Fibroblast on Pore Size Controlled Three-dimensional Scaffolds by Three-dimensional Bioprinting
D. J. Choi*1, C.-H. Kim1, S. J. Park1, S. Chung2, 1Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea, 2Korea University, Seoul, Republic of Korea

809. Freeform Fabrication Tri-Stimuli-Responsive Alginate-Based Hydrogels
C. J. McKenzie*, R. Oldinski, J. Etter, University of Vermont, Burlington, VT

810. Conductive 3D-printable Graphene Reinforced Bioinks for Neural Applications
S. Shafiee Nezhad, University of Illinois at Chicago, Chicago, IL

3D Printing and its Impact on Biomedicine

811. 3D Printed Scaffolds for Haversian Micro-Architecture
B. Ruliffson*1, S. Montelongo1,2, M. Burns3, M. Appleford1,2, 1University of Texas at San Antonio, San Antonio, TX, 2University of Texas Health and Science Center at San Antonio, San Antonio, TX, 3Louis D Brandeis High School[School, San Antonio, TX

812. Effect of Post-Processing and Porosity on Fatigue Performance of Selective Laser Melted Ti-6Al-4V ELI
F. B. Torstrick*1, D. L. Safranski2, K. Dupont2, N. Evans1, C. Irvin1, K. Gall3, 1Georgia Institute of Technology, Atlanta, GA, 2MedShape, Inc., Atlanta, GA, 3Duke University, Durham, NC

813. - Withdrawn

814. Controlled Delivery of Fluorophores from 3D Two-Photon Photolithographic Printed Poly(Ethylene Glycol) Methacrylate Scaffolds
A.-V. Do*, K. Worthington, B. Tucker, A. Salem, The University of Iowa, Iowa City, IA

815. Additive Manufacturing of multi-structural Implants for Regenerative Medicine
R. Brünler*, D. Aibibu, C. Cherif, Institute for Textile Machinery and High Performance Material Technology, Dresden, Germany

Advanced Bioinks for 3D Printing of Tissues and Organs

816. In Vitro and In Vivo Study of Bioresorbable Vascular Scaffolds Produced Using A Multi-axial 3D Printing Technology
J. Zhang*1, XB. Weng1, L. Cao1, S. Yang1, D. Jia1, Q. Zhao1, Q. Liu1, B. Zheng2, M. Chen2, X. Wang2, Q. Shi2, Y. Huo2, 1Beijing Advanced Medical Technologies, Beijing, China, 2First Affiliated Hospital of Beijing University, Beijing, China

817. Control of Drug Vector Release Kinetics From a 3D Printed Thiol-ene Cross-Linked Bioink
T. Jungst1, B. Baumann2, S. Stichler1, S. Feineis1, O. Wiltschka2, M. Kuhlmann1, M. Lindén2, J. Groll*1, 1University of Wuerzburg, Wuerzburg, Germany, 2University of Ulm, Ulm, Germany

818. 3D Cell Printing Systems for Precise Building of Collagen-based 3D Cell-laden Constructs
G. Ahn*1, K.-H. Min2, C. Kim1, J.-S. Lee2, D. Kang2, W.-S. Yun2, S. Jin2, J.-H. Shim2, 1T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, 2Korea Polytechnic University, Siheung-Si, Republic of Korea

819. Generation of Vessel Structure using Gelatin-based Bioink and Bioprinter
S. Hong*, J. S. Kim, C. Hwang, Asan Medical Center, Seoul, Republic of Korea

820. Influence of Polyvinylpyrrolidone-based Bio-ink Properties on Viability and Homogeneity of Printed Cells
W. L. Ng*1, W. Y. Yeong1, M. Win Naing2, 1Nanyang Technological University, Singapore, 2Singapore Institute for Manufacturing Technology (SIMTech), Singapore

821. Cartilage-Derived Extracellular Matrix Methacrylamide for 3D Bioprinting
Z. Galliger*1, J. Wollack2, A. Panoskaltsis-Mortari1, 1University of Minnesota, Minneapolis, MN, 2St. Catherine University, St. Paul, MN

822. Alginate/Gelatin as a Tunable Bioprinting Hydrogel to Study Tumor Spheroid Formation
T. Jiang*1, J. G. Munguia-Lopez2, J. Grant1, S. Vijayakumar1, K. Gu1, M. M. Bavoux3, A. De Leon-Rodriguez2, J. M. Kinsella1, 1McGill University, Montreal, QC, 2Instituto Potosino de Investigación Científica y Tecnológica, A.C. (IPICyT), San Luis Potosi, Mexico, 3Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Biomaterial Platforms for Guiding Organoid Development and Organ Culture

823. A Three-Dimensional Brain Organoid Platform for Disease Modeling and Drug Screening
M. Jorfi*, C. D’Avanzo, D. Y. Kim, D. Irimia, Massachusetts General Hospital, Harvard Medical School, Boston, MA

824. Oxygen Microenvironment Sensing in Three-dimensional Human Intestine-like Tissue
G.-A. Kim*, D. R. Hill, C. S. Lynn, S. Huang, D. Mukherjee, V. B. Young, J. R. Spence, S. Takayama, University of Michigan, Ann Arbor, MI

825. Synthetic Hydrogels for Human Intestinal Organoid Generation and Colonic Wound Engraftment
R. Cruz-Acuña*1, M. Quirós2, A. E. Farkas3, P. H. Dedhia2, S. Huang2, D. Siuda2, V. Garcia-Hernandez2, J. R. Spence2, A. Nusrat2, A. J. García1, 1Georgia Institute of Technology, Atlanta, GA, 2University of Michigan, Ann Arbor, MI, 3Hungarian Academy of Sciences, Szeged, Hungary

826. Adipogenic Differentiation of Human Adipose-Derived Stem Cells Grown as three-dimensional In Vitro Model
S. Fitzgerald*, J. Cobb, A. V. Janorkar, University of Mississippi Medical Center, Jackson, MS

827. Neural network reconstruction on sliced acellular brains for brain organoids
T. Kimura*1, N. Nakamura1, Y. Hashimoto1, A. Odawara2, I. Suzuki2, A. Kishida1, 1Tokyo Medical and Dental University, Tokyo, Japan, 2Tohoku Institute of Technology, Sendai, Japan

828. Biomimetic Surface Modification Platform for PLLA Scaffolds
C. Williams*, N. Richbourg, V. Sikavitsas, University of Oklahoma, Norman, OK

829. Novel Analysis of in Vitro Breast Tissue Test System
S. C. Rowlinson*1, W. C. Bridges1, K. J. L. Burg2, 1Clemson University, Clemson, SC, 2University of Georgia, Athens, GA

830. Synthetic Hydrogel Scaffolds for Modeling Intestinal Epithelial Homeostasis In Vitro
R. L. Wilson*, J. Grande-Allen, Rice University, Houston, TX

831. Engineering a Long-term and Highly Functional 3D Human Liver Model Using Silk Scaffolds
S. R. Khetani*1, D. Kukla1, W. Stoppel2, D. Kaplan2, 1University of Illinois at Chicago, Chicago, IL, 2Tufts University, Medford, MA

832. 3-Dimensional Chemically Modified Biodegradable Hydrogels for the Study of Valvular Interstitial Cell Phenotype in Vitro
K. E. Coombs*, M. N. Rush, E. Hedberg-Dirk, University of New Mexico, Albuquerque, NM

Biomaterials Designs for Temporally Controlled Release of Multiple Factors to Promote Tissue Regeneration

833. Controlled Linoleic Acid Release in a Hydrogel-Based Mammary Adipose Tissue Model
K. Andre*, C. Gomillion, University of Georgia, Athens, GA

Biomaterials for Regenerative Engineering

834. Engineering a Dual-Layer Chitosan-Lactide Hydrogel to Create Endothelial Cell Aggregate-induced Microvascular Networks In Vitro and Increase Blood Perfusion In Vivo
T. Kawai1, D. Wang2, Y. Yang2, 1Kyoto University, Sakyo-ku Kyoto, Japan, 2Stanford, Stanford, CA

835. Investigating the Shear-Induced Formation of a Gel Layer (a.k.a. Lamina Splendens) in Synovial Fluid
S. Cook*, Y. Guan, N. Pacifici, E. Czako, D. Gourdon, Cornell University, Ithaca, NY

836. Porous PLGA Scaffolds Incorporating Decellularized Extracellular Matrices for Kidney Tissue Regeneration
Y. Kim1, E. Lih1, S. y. Chun2, Y. k. Joung1, T. G. Kwon2, W.-G. Koh3, K. D. Park4, D. K. Han*1, 1Center for Biomaterials, Korea Institute of Science and Technology, Seoul, Republic of Korea, 2Kyungpook National University, Daegu, Republic of Korea, 3Korea University of Science and Technology, Seoul, Republic of Korea, 4Ajou University, Suwon, Republic of Korea

837. Gellan Gum-Poly-L-Lysine Complexes for Cell Encapsulation
S. Vieira*, A. S. Morais, R. L. Reis, J. M. Oliveira, 3B’s Research Group, Guimarães, Portugal

838. Design Optimization of PEG-Based Peptide-Conjugated Hydrogels through Multiscale Molecular Modeling Methods
X. Li*1, R. A. Latour1, S. N. Murthy2, M. L. Becker3, 1Clemson University, Clemson, SC, 2Rutgers University, Piscataway, NJ, 3University of Akron, Akron, OH

839. Extracellular Matrix BIofibers
K. Roberts*, J. Schluns, J. Hestekin, J. Wolchok, University of Arkansas, Fayetteville, AR

840. Integrating Experiments and Molecular Dynamics Simulations to Understand the Degradation Mechanisms of Bioresorbable Fibers
R. Vaid*, M. A. Pasquinelli, M. W. King, NC State University, Raleigh, NC

841. Collagen- and Elastin-Rich Biomaterial Isolated from the Skin of Aplysia californica
V. A. Webster*, P. McClellan, O. Akkus, U. Gurkan, H. J. Chiel, R. D. Quinn, Case Western Reserve University, Cleveland, OH

842. A Study of Load Transition in Partially Absorbable Hernia Mesh on the Healing Response of a Chronic Abdominal Wall Defect in a Rabbit Model
G. Hilas, J. Corbett, Poly-Med, Inc., Anderson, SC

843. - Withdrawn

844. Effect of pH on Hydrodynamic Size of Chondroitin Sulfate and Biomimetic Proteoglycans Dissolved in Aqueous Solution
E. Phillips, K. Prudnikova, M. Marcolongo, Drexel University, Philadelphia, PA

845. Cell-Seeded Synthetic Scaffold for Esophageal Regeneration
S. Soliman*, S. La Francesca, Biostage, Holliston, MA

846. Molecular Dynamics Simulations of PLA Using Reactive Force-Field
C. R. Gajjar*, M. A. Pasquinelli, M. W. King, North Carolina State University, Raleigh, NC

847. Process-Property Relationships for Bioabsorbable Polymers
C. R. Gajjar*, M. W. King, North Carolina State University, Raleigh, NC

848. Evaluation of Gelatin Based Hydrogel as Bio-ink Application
J. S. Kim1, S. Hong2, C. Hwang1,2*, 1University of Ulsan College of Medicine, Department of Medicine, Korea, 2Department of Medical Engineering R&D Center, Asan Institute for Life Sciences, Korea

849. Microstructural Characterization and in vitro Bioactivity of Aligned Polymer/hydroxyapatite Scaffolds for Bone Regeneration by Synchrotron Radiation X-ray Microtomography
S. Gorodzha*1, V. Weinhardt2, R. Shkarin3, M. Surmeneva1, G. Vacun4, T. Baumbach3, R. Surmenev1, 1National Research Tomsk Polytechnic University, Tomsk, Russian Federation, 2Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany, 3Laboratory for Applications of Synchrotron Radiation, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany, 4Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany

850. Bovine Pericardium Patch as an Implant for Surgical Repair Applications
S. Batra*, CollaFirm LLC, Monmouth Junction, NJ

851. Endotoxin Removal from Type A Gelatin using Surfactants
J. Olijve*, Rousselot, Son, Netherlands

852. Folic Acid-Stabilized Copper Metal-Organic Frameworks Improve Wound Healing in Diabetes
J. Xiao, P. Li, O. Farha, G. Ameer*, Northwestern University, Evanston, IL

852a. Efficiently Improving Cell Adhesive Property of Poly (amino acid) by Co-polymerizing with Cyclic Phosphoester
Y. Xiong*, College of physical science and technology, Sichuan University, Chengdu, China

Enzyme-assisted biomaterial fabrication and modification for biological applications

853. Enzyme-Immobilized Hydrogels for In Vitro Hypoxic Cancer Cell Culture
C. S. Dawes*1, C.-C. Lin1, H. Konig2, 1Indiana University-Purdue University Indianapolis, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN

854. Transglutaminase Crosslinking of Resilin-based Proteins for Vascular Applications
Y. Kim, E. E. Gill, J. C. Liu*, Purdue University, West Lafayette, IN

Evaluation of Tissue Engineering Constructs

855. Design and Analysis of Bioengineered Models of Alzheimer’s Disease
L. M. Walker*, J. B. Leach, University of Maryland Baltimore County, Baltimore, MD

856. Space & Cost Saver Bioreactor for Engineering Muscle/Tendon Tissue
T. He*1, R. Dennis1,2, M. W. King1, 1North Carolina State University, Raleigh, NC, 2University of North Carolina at Chapel Hill, Chapel Hill, NC

857. Reconstruction of Full Thickness Human Skin by 3D Bio-printing with Skin Bioink
J.-Y. Won1, H. Kim1, M. k. Kim1, G. Ahn1, W.-S. Yun2, J.-H. Shim2, 1T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, 2Korea Polytechnic University, Siheung-Si, Republic of Korea

858. Evaluation of Bone Substitutes using a Rabbit Posterolateral Lumbar Intertransverse Process Spinal Fusion (PLF) Model: A Subchronic Pilot Study
M. Assad*1, D. Beaudry1, A. Forcione1, M. Chagnon1, F. Soza1, R. Turcotte1, M. Beaudoin1, Y. Trudel1, B. Lussier2, 1AccelLAB Inc., Boisbriand, QC, 2Université de Montréal, St-Hyacinthe, QC

Genome Editing Tools for Tissue Regeneration

859. High Content Analysis Platform for Optimization of Lipid Mediated CRISPR-Cas9 Delivery Strategies in Human Cells
B. Steyer, A. Abdeen, J. Carlson-Stevermer, N. Angenent-Mari, A. Khalil, T. Harkness, K. Saha*, University of Wisconsin-Madison, Madison, WI

Glycomaterials

860. - Withdrawn

861. Chitosan Fibers for various Biomedical Applications
M. Wöltje*, R. Brünler, T. Kocaman, M. Eger, D. Aibibu, C. Cherif, Technical University Dresden, Dresden, Germany

Improved Construction of Stem Cell-Based Biomaterials

862. Expanding the Sample Space – Optimizing Materials for Complex, Spatially-Patterned Human Articular Cartilage
K. H. Parratt*1, M. Smerchansky1, Q. Stiggers2, K. Roy1, 1Georgia Institute of Technology, Atlanta, GA, 2University of Michigan, Ann Arbor, MI

863. Extent of Modification of Hyaluronic Acid Influences CD44 Binding and MSC Chondrogenesis
M. Y. Kwon*, R. L. Mauck, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

864. Aligned Substrate Topography induces MSC tenogenic differentiation through the Rho/ROCK pathway
T. Suzuki*, O. Akkus, Case Western Reserve Univeristy, Cleveland, OH

865. The Effect of Fibrinogen Concentration on Chondrocyte Proliferation
A. J. McNally*, J. Van Deven, C. Chapman, L. Krengel, K. Sly, S. Lin, Exactech, Inc., Gainesville, FL

866. - Withdrawn

Interfacial Tissue Engineering

867. Combinatorial Effects of Cyclic Tensile Strain and Local Biomaterial Cues on Tendon-Bone-Junction Engineering
W. K. Grier*, B. A. C. Harley, University of Illinois Urbana-Champaign, Urbana, IL

Irradiation of Biomaterials: Recent Development

868. Annealing Effects on Poly(glycolide-co-L-lactide) Multifilaments Following Irradiation Treatment
M. Deng*, K. Tamsula, E. Vailhe, S. Rothenburger, D. Stoloff, F. Halperin, Johnson & Johnson, Somerville, NJ

Materials Aspect of In Situ Tissue Engineering

869. - Withdrawn

Regulating Stem Cell Differentiation

870. Controlled Regulation of Mesenchymal Stem Cell Response In Vitro Using Laser- Engineered Bio-Interfaces
L. N. Rusen1, L. E. Sima2, 1National Institute for Lasers,Plasma and Radiation Physics, Bucharest, Romania, 2Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

871. Theranostic Nanoparticles To Promote Osteogenesis And Photoacoustic Imaging of Mesenchymal Stem Cells
I. Adjei*, H. Yang, L. Maldonado-Camargo, J. Dobson, C. Rinaldi, H. Jiang, B. Sharma, University of Florida, Gainesville, FL

872. Calcium Alginate-Collagen Gels as Depots of Differentiation Factors and Bioactive Glasses for Mesenchymal Stem Cell Osteoinduction
E. Diaz*, M. Hutchinson, B. Dill, J. Curtis, R. C. de Guzman, Hofstra University, Hempstead, NY

873. Impact of Calcium Concentration on Cell Viability, Transfection Efficiency, and Osteogenic Differentiation in Bone Marrow-derived Stem Cells
T. Acri*, K. Shin, A. Salem, University of Iowa, Iowa City, IA

874. Silicone and Carbon Nanotube Substrates with Pulsed Current for Osteoblastic MSCs Differentiation
R. C. de Guzman*, Hofstra University, Hempstead, NY

875. Nanofiber Scaffold Fiber Density Modulates Mesenchymal Stem Cell Differentiation with Correlation to Cell Morphology
D. Chen*1, W. Losert1, S. Sarkar2, 1University of Maryland, College Park, MD, 2National Institute and Standards and Technolgy, Gaithersburg, MD

876. - Withdrawn

877. Dynamic Interstitial Fluid Flow and Matrix Stiffness Influence Osteogenesis of Human MSCs in a Bilayer Hydrogel
A. Aziz*, S. Bryant, University of Colorado at Boulder, Boulder, CO

878. Nanotopography Promoted Neuronal Differentiation of Human Induced Pluripotent Stem Cells
K. Wang1, L. Song2, Y. Li2, Y. Yang*1, 1West Virginia University, Morgantown, WV, 2Florida State University, Tallahassee, FL

Soft Tissue Regeneration Using Hierarchical Structures

879. Construction of Stromal Tissue Balls with High-Density ECM and Blood Capillary
M. Komeda*, M. Matsusaki, Osaka Univ., Osaka, Japan

880. Syncytial Myoblast Fusion is Regulated by Muscle Extracellular Matrix and Integrin α7β1 Signaling
M. J. McClure*1, J. Cohen1, MH. Sunwoo2, Y. C. Huang2, E. Imming2, B. D. Boyan1, Z. Schwartz1, 1Virginia Commonwealth University, Richmond, VA, 2Musculoskeletal Transplant Foundation, Edison, NJ

881. Tuning the Architecture of 3D Collagen-based Hydrogel Constructs using Polyvinylpyrrolidone Macromolecules
W. L. Ng*1, W. Y. Yeong1, M. Win Naing2, 1Nanyang Technological University, Singapore, Singapore, 2SIMTech, Singapore, Singapore

882. Towards Bio-Instructive Scaffolds: Identifying Geometry Directed Stem Cell Differentiation with RNA-Sequencing
B. Banik*1, E. Witmer1, L. Rieber2, S. Mahony2, J. Brown1, 1Department of Biomedical Engineering, 2 Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA

Supramolecular Materials for Biomedical Applications

883. Porphyrin Micro-nano Particles Mimicking Viral Morphology for Enhanced Cellular Delivery and Photodynamic Therapy
W. Zhang*, H. Li, Y. Qin, C. Gao, Zhejiang University, Hangzhou, China

884. Affinity-controlled Lectin Delivery Via Self-Assembled Glycopeptide Hydrogels
M. Fettis*, A. Restuccia, G. A. Hudalla, University of Florida, Gainesville, FL

885. Self-Assembling Peptide Nanofiber Constructs as Defined 3D Cell Culture Matrices
F. Gu*1, J. Handley2, Y. Wu1, D. Vander Griend2, J. H. Collier1, 1Duke University, Durham, NC, 2University of Chicago, Chicago, IL

886. Platelet Behavior on Micron and Sub-Micron Fibres of Bioresorbable Supramolecular Polymer
L. D. Burke*, M. Cox, F. Zomer Volpato, Xeltis B.V., Eindhoven, Netherlands

887. Manufacturing Methacrylated Sodium Alginate Beta-Cyclodextrin Microspheres for Drug Delivery
M. Karasinski*1, J. Etter1, R. Oldinski2, 1University of Vermont College of Engineering and Mathematical Sciences, Burlington, VT, 2University of Vermont, Larner College of Medicine, Burlington, VT

Tissue Engineered Disease Models

888. An ex vivo 3D-Cancer Models with Blood/Lymph Capillaries Elucidate Local Secretion of Different Types of MMPs during Metastasis Process
M. Matsusaki, A. Nishiguchi, M. Akashi, Osaka University, Osaka, Japan

889. Human Aortic Valve Interstitial Cells Mechanotransduction by an outside-in YAP-dependent Signal Transduction Pathway
R. Santoro*1, D. Scaini2, L. Ulloa Severino2, F. Amadeo1, G. Polvani1, L. Casalis2, M. Pesce1, 1Centro Cardiologico Monzino, Milan, Italy, 2Synchrotron Light Source, Basovizza, Italy

890. A Rat Model of Severe Osteoporosis for Testing Bone Regeneration Constructs
M. Waters*, N. Potter, M. Thompson, A. Trent, M. Van Dyke, Virginia Tech, Blacksburg, VA

891. Aged Skeletal Muscle ECM Promotes Enhanced Pro-inflammatory Macrophage Response
S. T. LoPresti*1, S. Victor2, B. N. Brown1, 1University of Pittsburgh, Pittsburgh, PA, 2McGowan Institute for Regenerative Medicine, Pittsburgh, PA

892. Surface Marker Expression of Bone Marrow- and Adipose-derived Stem Cells from a Rat Model of Severe Osteoporosis
M. Waters*, S. Lavery, N. Potter, M. Thompson, A. Trent, M. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, VA

893. Ontomimetic Differentiation of Patient-Derived hiPSCs to Study Congenital Heart Disease
M. Ellis*, E. Lipke, Auburn University, Auburn University, AL

894. Generation of Glycosaminoglycan-Enriched Scaffolds to Decipher Aortic Valve Disease Pathobiology
A. M. Porras*, J. Westlund, A. Evans, K. S. Masters, University of Wisconsin-Madison, Madison, WI

Tissue Engineering

895. A Comparative Study of the Bone Regenerative Effect of Chemically Modified RNA Encoding BMP-2 or BMP-9
B. Khorsand*1, S. Elangovan1, L. Hong1, A. Dewerth2, M. Kormann2, A. K. Salem1, 1The University of Iowa, Iowa City, IA, 2University of Tübingen, Tübingen, Germany

896. Seamless Scaffolds Containing Gradients of Microspheres for Tissue Engineering
A. Najarzadeh*, D. Puleo, University of Kentucky, Lexington, KY

897. Nerve Regeneration Using Lysophosphatidylcholine and Nerve Growth Factor
R. Wood*, M. Landeen, A. Thompson, S. C. Steffensen, W. G. Pitt, A. D. Cook, Brigham Young University, Provo, UT

898. Covalently-linked Modifiers for Protein Adsorption and Cell Attachment onto PEG Gels
R. Wasserman1, K. Lewis*2, R. C. deGuzman2, 1Hofstra University, Fort Lauderdale, FL, 2Hofstra University, Hempstead, NY

899. Evaluation and Ultrasound-Mediated Hydrogelation of Short, Self-Assembling Peptides for use as Modular Tissue Engineering Scaffolds
A. D. Noblett*, L. Suggs, The University of Texas at Austin, Austin, TX

900. Bioactive Glass Scaffolds for Dental Pulp and Dentin Tissue Engineering
H. Shawli*, R. Baier, A. Meyer, R. Dziak, SUNY at buffalo, Buffalo, NY

901. Utilization of 3D Spheroid Culture System and Vascular Endothelial Growth Factor (VEGF) to Enhance Endothelial Differentiation of Human Adipose Derived Stem Cells
K. Clark*, A. Janorkar, Univ of Mississippi Medical Center, Jackson, MS

902. Novel Amorphous Silica Fused Fiber Matrix for Bone Tissue Engineering
S. Nukavarapu1, H. Kim*1, M. Lyles2, 1University of Connecticut, South Windsor, CT, 2University of Rhode Island, Kingston, RI

Tissue Engineering Scaffold Fabrication

903. Formation of Nanofibrous 3D Scaffolds and Injectable Microspheres: From Theory to Practice
C. Ma*, X. Liu, Texas A&M University College of Dentistry, Dallas, TX

904. Physical Characterization of Elastin-like Polypeptide and Collagen Composites with Varied Scaffold Formulations
B. Gurumurthy*, A. Janorkar, University of Mississippi Medical Center, Jackson, MS

905. A New Generation of Electrospun 3D Nanofibrous Scaffold with Interconnected and Hierarchically Structured Pores for Bone Tissue Engineering
H. Sun*1, Q. Yao1, T. Xu2, J. M. Miszuk1, H. Fong2, 1University of South Dakota, Sioux Falls, SD, 2South Dakota School of Mines and Technology, Rapid City, SD

906. Development of Tissue Scaffolds for Biomedical Applications using Computer Aided Tissue Engineering
M. Gogoi, North Eastern Hill University, Shillong, India

907. Nanocellulose-PE-b-PEG Copolymer Nanohybrid Shish-Kebab Structure and Interaction with MC3T3-E1 Cells
M. Ochoa, N. Collazos, T. Le, R. Subramanian, University of Louisiana at Lafayette, Lafayette, LA

908. Evaluating Cell Proliferation for Hydroxyapatite Scaffold Architectures using 3D-Plotting.
A. Kuthe, P. Sapkal*, S. Kuthe, Visvesvaraya National Institute Of Technology, Nagpur, India

909. Cell Micropatterning on Cell Surfaces Using Multi-Armed-Poly(Ethylene Glycol)-Eicosapentaenoic Acid
K. Yanagisawa*, M. Matsusaki, Osaka University, Osaka, Japan

910. Electrochemical Fabrication of Elastin Containing Bi-layered Vascular Scaffold
T.-U. Nguyen, C. A. Bashur, V. Kishore*, Florida Institute of Technology, Melbourne, FL

911. Synthesis and Degradation of Poly(β-amino ester) Fibers
T. A. Q. Phan*, University of Kentucky, Lexington, KY

912. Pcl/Gelatin Nanocomposite Scaffolds for Potential use as Ligament or Tendon Substitutes
S. Matin Nikoo*, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran, Tehran, MN

913. Cell Adhesion on Composite Bone Scaffolds Developed by a Hybrid 3D-Bioplotting/Thermally-Induced Phase Separation Technique
R. Sheppard*, J. Liu, C. Flavin, J. Silverstein, J. Zhang, J. Powers, P. F. James, A. Yousefi, Miami University, Oxford, OH

914. Polylactic-based Scaffolds Doped with Calcium Silicate/Calcium Phosphate: Chemical-Micromorphological Analyses.
M. G. Gandolfi*1, F. Zamparini1, M. Degli Esposti1, P. Fabbri1, C. Aparicio2, F. Fava1, C. Prati1, 1University of Bologna, Bologna, Italy, 2University of Minnesota, Minneapolis, MN

915. Enhanced Biocompatibility on Ta-implanted Poly(lactic acid) Surface
C. Park*, S. Kim, T.-S. Jang, H.-E. Kim, Seoul National University, Seoul, Republic of Korea

916. Electrically Conductive Graphene/Polyacrylamide Hydrogels for Enhanced Myoblast Growth and Differentiation
H. Jo, M. Sim*, S. Kim, S. Yang, M.-G. Kim, J. Y. Lee, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea

917. Bilayered Scaffolds (Loofah/PLLA/cellulose/chitin) for Osteochondral Defect Repair: Synthesis and In-vitro Characterization
B. Cecen*, Dokuz Eylul University, Izmir, Turkey

918. Novel Polyacrylates supported Human Aortic Valve Interstitial Cells Growth and Physiologic Differentiation in a 3D Environment
R. Santoro*1, S. Venkateswaran2, F. Amadeo1, R. Zhang2, M. Agrifoglio1, M. Bradley2, M. Pesce1, 1Centro Cardiologico Monzino, Milan, Italy, 2University of Edinburg, Edinburg, United Kingdom

919. Enzymatically Cross-Linked Silk Fibroin Scaffolds Support Human Adipose-Derived Stem Cells Chondrogenesis
V. P. Ribeiro*1, A. da Silva Morais1, F. R. Maia1, A. L. Oliveira2, J. M. Oliveira1, R. L. Reis1, 13B´s Research Group, Biomaterials, Biodegradables and Biomimetics Dept. of Polymer Engineering, University of Minho, Guimarães, Portugal, 2CBQF–Center for Biotechnology and Fine Chemistry, Portuguese Catholic University, Porto, Portugal

920. Coaxial Electrospun Fiber System for Prolonged Dexamethasone Release Targeting Cardiac Infarction
D. Gadalla, V. Lalwani, J.-Q. He, A. Goldstein*, Virginia Tech, Blacksburg, VA

921. Efficient Parametric Way to Induce Customized Internal 3D Porosity in Grafts for Bone Tissue Engineering
D. Gupta*, J. Bellare, Indian Institute of Technology Bombay, Mumbai, India

922. Effect of Print Direction on Mechanical Properties of a 3D Printed Flexible Lactide-based Copolymer
M. S. Taylor*, J. Hyde, B. Gaerke, M. A. Vaughn, B. Johns, Poly-Med, Inc., Anderson, SC

923. Functionalization of 3D Electrospun Nanofibrous Polycaprolactone Scaffolds for Bone Tissue Engineering
J. Miszuk*1, T. Xu2, H. Fong2, H. Sun1, 1University of South Dakota, Sioux Falls, SD, 2South Dakota School of Mines & Technology, Rapid City, SD

924. Electrospun Poly(ε-caprolactone) Nanofiber Shish Kebabs Mimic Mineralized Collagen Fibrils in Bone
M. Marcolongo, C. Li, T. Yu*, Drexel University, Philadelphia, PA

925. - Withdrawn

926. 3D Bioprinting Collagen Scaffolds for Engineering Human Cardiac Tissue
A. Lee*, T. J. Hinton, A. Hudson, A. Feinberg, Carnegie Mellon University, Pittsburgh, PA

927. Synthetic Hydrogel Supports the Development of Mouse Primary Ovarian Follicles Co-Cultured with Adipose Derived Stem Cells
H. Zhou*, L. J. Green, AM. E. Opipari, A. Shikanov, University of Michigan, Ann Arbor, MI

928. 3D Dynamic Culture of Trabecular Meshwork Cells
M. Osmond1, M. B. Pantcheva2, M. D. Krebs*1, 1Colorado School of Mines, Golden, CO, 2University of Colorado Denver School of Medicine, Aurora, CO

929. Osteoblast Loaded Injectable Hydrogel/Ti-6Al-4V System for the Faster Bone Regeneration
A. Kumar*, University of Texas at El Paso, El Paso, TX

930. - Withdrawn

931. Mechanical and Biological Evaluation of Knitted Poly-L-lactic Acid Scaffold for Delivery of Cardiosphere Derived Cells (CDCs)
J. Chen*, K. Cheng, A. J. West, North Carolina State University, Raleigh, NC

932. PCL/Magnesium Based Composite Nanofibers for Peripheral Nerve Repair Application
U. Adhikari*, North Carolina A&T State University, Greensboro, NC

933. Flow-Induced Shear Distributions on 3D Printed Scaffolds
C. Williams*, V. Sikavitsas, University of Oklahoma, Norman, OK

934. Evaluating the Cytocompatibility and Differentiation of Bone Progenitors on Zein-Derived Scaffolds
J. Cardenas Turner*1, G. Collins1, E. A. Blaber2, E. A. C. Almeida2, T. L. Arinzeh1, 1New Jersey Institute of Technology, Newark, NJ, 2NASA Ames Research Center, Mountain View, CA

935. ROS-Degradable Scaffolds Enhance Tissue Regeneration in a Porcine Ischemic Wound Healing Model
J. R. Martin, Vanderbilt University, Nashville, TN

936. Two-Photon Polymerization of High-Resolution 3D, Biodegradable Photoreceptor Cell Scaffolds
K. S. Worthington*, J. R. Thompson, B. J. Green, S. J. Bunn, E. M. Stone, R. F. Mullins, A. Guymon, B. A. Tucker, The University of Iowa, Iowa City, IA

937. Direct Electrospinning of Cell-loaded Poly(oligoethylene glycol methacrylate) (POEGMA) Nanofibrous Gel Scaffolds
F. Xu*, T. Hoare, M. Dodd, H. Sheardown, McMaster University, Hamilton, ON

938. Optimization of an Empirical Cryopreservation Process for Engineered Hepatic Encapsulates
E. Johnson*, North Carolina A&T State University, Greensboro, NC

939. Electrostatic Encapsulation of Primary Hepatocytes in Alginate Microbeads
S. Khanal*, North Carolina A&T State University, Greensboro, NC

940. 3D Near-field Electrospinning: A New Approach for Manufacturing Fibrous Scaffold for Cellular Ingrowth
P. Fattahi*, J. T. Dover, J. L. Brown, The Pennsylvania State University, University Park, PA

941. Chondroinductive Hydrogels from Naturally Derived Cartilage Matrix
F. M. Acosta*1, M. Detamore2, 1University of Texas in San Antonio, Houston, TX, 2University of Oklahoma, Norman, OK

942. The Effect on Cell Initial Adhesion and Infiltration on Modified Chitosan Nanofiber Scaffolds
B. K. Gu*, S. J. Park, C.-H. Kim, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea

943. Implantable Autologous Dermal Tissues Prepared by High Hydrostatic Pressure for Treating Congenital Giant Melanocytic Nevus
T. Yamaoka*1, A. Mahara1, C. Jinno2, K. Kusumoto3, S. Suzuki2, N. Morimoto3, 1National Cerebral and Cardiovascular Center Research Institute, Suita, Japan, 2Kyoto University, Kyoto, Japan, 3Kansai Medical University, Hirakata, Japan

944. Pig Palate Stem Cells and Smart Scaffold as a Challenge for Cleft Palate
R. Rosales-Ibanez*1, A. Rodríguez-Navarrete2, M. L. Flores-Sanchez2, T. E. Villamar-Duque2, R. D. Andrade-Gonzalez2, G. Higuera-Martinez2, L. Rojo3, 1engineering Tissue Lab, UNAM/FESI, Ciudad De Mexico, Mexico, 2UNAM, Ciudad De Mexico, Mexico, 3Institute of Polymer Science & Technology, CSIC, Madrid, Spain

945. The In vitro and In vivo Investigation on Small Diameter Tissue Engineering Vascular Scaffold Made from Heparin Modified Polycaprolactone (hPCL)
L. Ye*, Beijing Institute of Technology, Beijing, China

946. Development of Poly(proylene fumarate) (PPF), Vinyl phosphonic acid (VPA) and Vinyl phosphonic acid diethyl ester (VPES) Based Scaffolds for Bone Tissue Engineering
G. Cemali*, G. Köse, E. Can, Yeditepe University, İstanbul, Turkey

947. Effects of 3D Printing on Flow-Induced Shear Distributions
C. Williams*, V. Sikavitsas, The University of Oklahoma, Norman, OK

948. Hybrid Extracellular Matrix Scaffold for Tendon or Corneal Repair
Y-Y. Huang*, National Taiwan University, Taipei, Taiwan

949. Fabrication of Keratin/Gelatin/fibrin Based Biofilm from Indian Goat Hoof Waste Source for Wound Healing Applications
LK. S*1, A. S1, S. J1, S. M2, 1VEL Tech Multi Tech Dr Rangarajan Dr Sakunthala Engineering College, Chennai, Tamil Nadu, India, 2St Peters University, Chennai, Tamil Nadu, India

950. Fiber Length and Concentration - Synergistic Effect on Mechanical and Cellular Response in Wet-Laid poly(lactic acid) Fibrous Scaffolds
A. Wood*, D. Everett, V. Thomas, University of Alabama at Birmingham, Birmingham, AL

Nanomaterials SIG

Interfacial Tissue Engineering

951. Nanoparticles Enhanced Adhesion Strength of Mussel-inspired Based Hydrogels
N. Pandey*1, S. Yaman1, B. Rodionov1, V. Jones1, P. Zimmern2, K. T. Nguyen1, Y. Hong1, 1University of Texas at Arlington, Arlington, TX, 2University of Texas Southwestern Medical Center, Dallas, TX

Nanomaterials

952. Gold Quantum Cluster-Photosensitizer conjugate for fluorescence Imaging Assisted Photodynamic Therapy
R. S. Jayasree*, Sree Chitra Tirunal Institue for Medical Sciences and Technology, Trivandrum, India

953. Synthesis of Functional Gold Nanoparticles Resistant to pH and Salt for biomedical applications
G. Pandey*, B.R.D. Medical College, Gorakhpur, india, GORAKHPUR, India

954. Enhanced Antibacterial Property of Self-Assembling Peptide Amphiphiles Functionalized with Heparin-Binding Cardin-Motifs
R. Chang*, T. Webster, K. Subramanian, M. Wang, Northeastern University, Boston, MA

955. Protection of Human Vascular Endothelial Cells from Oxidative Stress Damage through Autophagy Induced by Iron Oxide Nanoparticles
r. Jin*1, j. Du1, J. Anderson2, H. AI(1,3), 1National Engineering Research Center for Biomaterials, Chengdu, China, 2Case Western Reserve University, Cleveland, OH, 3West China Hospital, Sichuan University, Chengdu, China

956. Silver Nanoparticles & Ion Silver in the Antimicrobial Activity
L. L. F. Gorup*1, F. N. Souza Neto2, A. M. Kubo2, J. A. S. Souza3, R. A. Fernandes3, G. L. Fernandes3, D. R. Monteiro3, D. B. Barbosa3, E. R. Camargo4, 1University of Michigan, Ypsilanti, MI, 2University of São Carlos, São Carlos, Brazil, 3UNESP, Araçatuba, Brazil, 4UFSCar, São Carlos, Brazil

957. Lumbricus Terrestris Erythrocruorin-Poly(acrylic acid) Nanoparticles for a Ultra-Stable Hemoglobin Based Oxygen Carriers
K. Spivack*, Villanova University, Villanova, PA

958. Self-assembly of Aromatic Dipeptides and Tri-peptides Utilizing Electrostatic Forces
Y. Hamedani*, M. Vasudev, University of Massachusetts Dartmouth, North Dartmouth, MA

959. Development of Nanoscale Ceria-SOD Antioxidant Conjugates
V. Ivanov1, J. Rodriguez*2, D. Gil2, V. Reukov2, 1Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russian Federation, 2Clemson University, Clemson, SC

960. Graphene Quantum Dot Synthesis using Nanosecond Laser Pulses for Pathogenic Bacteria Deactivation
K. Kholikov*, Z. Thomas, D. Seyitliyev, S. Smith, A. Er, Western Kentucky University, Bowling Green, KY

Protein and Cells at Interfaces SIG

Engineering Tissue and Material Interfaces

961. Gellan Gum Based Thiol-ene Hydrogels with Tunable Properties for use as Tissue Engineering Scaffold
Z. Xu*, Z. Li, S. Jiang, K. Bratlie, Iowa State University, Ames, IA

962. Mechanical Characterization of a Novel Bifunctional Tetronic® Hydrogel Adhesive for Surgical Mesh Fixation
X. Lu*, M. Alejos, J. Nagatomi, M. Harman, Clemson University, Clemson, SC

963. Cell-Substrate Interactions on Keratin Biomimetic Coating for Percutaneous Prosthetic Applications
A. R. Trent*, M. Van Dyke, Virginia Tech, Blacksburg, VA

964. Injectable and Thermosensitive Chitosan Hydrogels for the Prevention of Post-Operative Peritoneal Adhesions
E. Hui*, Ecole de Technologie Supérieure, Montreal, QC

965. Thermoresponsive Films for Human Embryonic Stem Cell Proliferation and Hepatic Differentiation
K. Ortiz-Rivera*, Y. Park, W.-S. Hu, C. Wang, University of Minnesota, Minneapolis, MN

966. Fabrication of New Bio-organic Collagen-Proteoglycan Composites forTendon and Ligament Tissue Engineering
H. Pajovich*, G. Knoll, A. Smith, S. Hurley, J. Dorilio, N. Cutrone, I. Banerjee, Fordham University, Bronx, NY

High-throughput methods to control cell behavior

967. Material Flow Cytometry - High-throughput, High Replicate Screening of Shape-specific Biomaterials for Stem Cell Differentiation
K. H. Parratt*, J. Jeong, P. Qiu, K. Roy, Georgia Tech, Atlanta, GA

968. Maximizing Human Induced Pluripotent Stem Cell Derived Neural Stem Cell Survival, Axon Extension and Gene Expression of Neural Differentiation Markers using Polyethylene Glycol Hydrogels Containing a Continuous Concentration Gradient in N-Cadherin Derived
H. J. Lim, Z. Kahn, T. H. Perera, T. S. Wilems, Y. Kurosu, K. T. Ravivarapu, M. C. Mosley, L. A. Smith Callahan*, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX

969. Engineering a MicroPhysiological Model of the Heart-Brain Axis
J. Soucy, R. A. Koppes*, Northeastern University, Boston, MA

Printing and Patterning of Cell Microenvironments

970. Rapid 3-D Microchannel generation using a Multiphoton Laser System as a Template for Microvasculature
M. Sameti1, S. R. Burtch1, R. D. Allado1, T. Olmstead2, C. A. Bashur*1, 1Florida Institute of Technology, Melbourne, FL, 2MEDOPHO, Orlando, FL

Protein and Cells at Interfaces

971. FXII Contact Autoactivation, Reciprocal Activation, and Autohydrolysis in Response to Solid Activators
C. A. Siedlecki*, Y. Yan, L.-C. Xu, The Pennsylvania State University, College of Medicine, Hershey, PA

972. Magnetic Field -dependent Protein Corona onto Superparamagnetic Iron Oxide Nanoparticles Influences Their Biological Behaviors
L. Zi. yao1, W. Yao*2, L. Fang*2, 1National Engineering Research Center for Biomaterials, Chengdu, China, 2Sichuan university, Chengdu, China

Supramolecular Materials for Biomedical Applications

973. Co-Assembly Tags based on Charge (CATCH) for Installing Functional Protein Ligands Into Supramolecular Biomaterials
D. Seroski*, A. Restuccia, G. Hudalla, University of Florida, Gainesville, FL

Orthopaedic Biomaterials SIG

Degradable Metal Biomaterials

974. Hybrid Scaffolds of Mg Alloy Mesh Embedded within Polymer/ECM Composite for Critical-Sized Calvarial Defect Reconstruction
Y. Chen*1,2, S.-H. Ye1, V. Shanov3, T. Tiasha3, G. Wan2, W. R. Wagner1, 1McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 2Key Laboratory of Advanced Technologies of Materials, Ministry of Education, College of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, PA, 3College of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH

975. Investigation of MC3T3-E1 Pre-osteoblast Apoptotic Response to Biodegradable Magnesium alloys
E. Bonyadi Rad1, S. Mostofi1, p. schmutz2, M. Pawelkiewicz2, m. katschnig3, U. Schäfer1, A. Weinberg*1, 1Medical University Graz, Graz, Austria, 2EMPA, Swiss Federal Laboratories for Materials Science and Technology, Duebendorf, Switzerland, 3Montanuniversitaet, Leoben, Austria

976. Corrosion Protection and Cytocompatibility of Titania/calcium Phosphate Composite Coating on an Mg Alloy
Y. Su*2, D. Zhu2, Y. Gao1, J. Lian1, G. Li1, 1Jilin University, Changchun, China, 2University of North Texas, Denton, TX

977. Effect of Heat Treatment on the Corrosion Resistance of AZ31 Alloy as a Biodegradable Implant
S. Khalifeh*, T. D. Burleigh, New Mexico Institute of Mining and Technology, Socorro, NM

Glycomaterials

978. Evaluation of Chitosan Film and Electrospun Membranes in Fibroblast and Osteoblast Culture
H. Su*, G. S. Selders, J. D. Bumgardner, The University of Memphis, Memphis, TN

Orthopaedic Biomaterials

979. Fabrication and Characterization of 3D Printed PLA/Ti Composite Scaffolds by FDM Process for Hard Tissue Engineering
J. Lee*, H.-D. Jung, Korea Institute of Industrial Technology, Incheon, Republic of Korea

980. Biomineral Coating Promotes Reduces Inflammatory Behavior of PEEK Implants
L. Jongpaiboonkit*1, V. Mondine1, N. Caras1, W. Murphy2, 1Tissue Regeneration Systems, Inc., Plymouth, MI, 2University of Wisconsin, Madison, WI

981. Modification of Bone-Derived Biological Apatite via Fluoride Incorporation: Changes in Physicochemical and Biological Properties
W. Qiao*1, K. W. K. Yeung1, J. K. H. Tsoi1, J. P. Matinlinna1, Z. Chen2, 1The University of Hong Kong, Hong Kong, China, 2Sun Yat-sen University, Guangzhou, China

982. Restoration of Bone Defects Using a CaSO4/CaPO4-TCP Bone Graft Substitute Compared to Cancellous Allograft
D. J. Hall*, T. M. Turner, S. M. McCarthy, J. L. Wright, R. M. Urban, Rush University Medical Center, Chicago, IL

983. Bioglass Incorporation Improves the Bioactivity of Electrochemically Aligned Collagen Fibers
M. Nijsure*, V. Kishore, Florida Institute of Technology, Melbourne, FL

984. Fabrication of Carbonate Apatite Honeycomb and its in vivo Evaluation
K. Ishikawa*, M. L. Munar, K. Tsuru, Kyushu University, Fukuoka, Japan

985. In Vivo Bone Tunnel Evaluation of Nanoparticle ACL Grafts
S. A. Grant*, S. E. Smith, H. Schmidt, S. Sherman, D. A. Grant, University of Missouri, Columbia, MO

986. A Patient Specific 3D Printed Scaffold for Femoral Long Segment Regeneration
J. Buchak*, A. Barreda, D. A. Gonzales, J.A. Szivek, J.L. Smith, University of Arizona, Tucson, AZ

987. Poly-methyl Methacrylate (PMMA) Bone Cement Incorporated with Hydroxyapatite (HA) Microspheres for Enhanced Biocompatibility and Radiopacity
I. Kang*, J.-U. Baek, H. Lee, C. Park, H.-E. Kim, Seoul National University, Seoul, Republic of Korea

988. Effect of Calcium Phosphate Reinforcement on Gelatin-Chitosan for Developing a 3D Porous Composite Scaffold for Bone Tissue Engineering- a Comparative Study
K. Maji*, S. Dasgupta, National Institute of technology Rourkela, Rourkela, India

989. 3D printed PCL/β-TCP Composite Scaffolds for Bone Regeneration in Femoral Defects
G. Ahn*1, J.-Y. Kim2, J.-S. Lee3, K.-H. Park3, W.-S. Yun3, S.-Y. Kim2, J.-H. Shim3, 1T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, 2Kyungpook National University Hospital, Daegu, Republic of Korea, 3Korea Polytechnic University, Siheung-Si, Republic of Korea

990. Effect of Solution Chemistry and Temperature on Taper Electrochemical Performance
V. Swaminathan*, J. Karwowski, H. Zeng, R. Lee, K. TenHuisen, Stryker, Mahwah, NJ

991. A Method for the Surface Characterization of Modular Connections in Total Hips
M. A. Di Prima*1, O. Vesnovsky1, L. D. T. Topoleski2, R. Hopper4, C. A. Engh4, P. Kovacs3, 1Food and Drug Administration, Silver Spring, MD, 2University of Maryland Baltimore County, Baltimore, MD, 3Private consultant, Santa Claus, IN, 4Anderson Orthopaedic Research Institute, Alexandria, VA

992. Characterization of a Novel Bioactive Glass and GAG Composite for Bone Grafting Applications
C. Goldbach*, M. Demir, D. Rodriguez, G. Pomrink, NovaBone Products, Alachua, FL

993. Osteoinductive Collagen-Calcium Citrate Composite Platform for Bone Tissue Engineering
M. Younesi*, H. Jin. Jang, T. Mbimba, O. Akkus, Case Western Reserve University, Cleveland, OH

994. Collagen Yarns for Rotator Cuff Repair Graft
Y. Xie*1, U. L. Erol2, O. Akkus2, E. R. Cadet3, M. W. King1, 1North Carolina State University, Raleigh, NC, 2Case Western Reserve University, Cleveland, OH, 3Raleigh Orthopaedic Clinic, Raleigh, NC

995. Perfusion Directed 3D Bone Mineral Formation
S. W. Sawyer*1, K. Zhang1, L. D. Albrecht1, A. S. Ramos1, A. B. Filip1, J. A. Horton2, P. Soman1, 1Syracuse University, Syracuse, NY, 2SUNY Upstate Medical University, Syracuse, NY

996. Corrosion Modes in Modular Taper Junctions Can Be Dictated by CoCrMo Alloy Microstructure
R. Pourzal*1, D. J. Hall1, R. M. Urban1, D. Bijukumar2, J. Ehrich1, J. J. Jacobs1, M. T. Mathew2, 1Rush University Medical Center, Chicago, IL, 2University of Illinois Medical College at Rockford, Rockford, IL, Chicago, IL

997. Attaching a Hydoxyapatite-binding Domain to BMP2-derived Peptides to Anchor Peptides onto Bone Graft Materials
A. S. Curry*, N. W. Pensa, S. L. Bellis, University of Alabama at Birmingham, Birmingham, AL

998. Application of Phase Space Warping to the Study of Fatigue in Bone
C. Skurla*, M. Cler, A. Campbell, J. Kuehl, Baylor University, Waco, TX

999. Magnetically Aligned Alginate-Hydroxyapatite Biocomposites for Bone Graft Applications
J. Faust*1, M. Riederer2, M. Krebs2, R. Erb1, 1Northeastern University, Boston, MA, 2Colorado School of Mines, Golden, CO

1000. Novel Antibacterial Coating on Orthopedic Implants
A. Frank-Kamenetskii1, V. Reukov1, C. Gross2, A. Vertegel1, 1Clemson University, Clemson, SC, 2Medical University of South Carolina, Charleston, SC

1001. Characterization of the Viscoelastic and Diffusive Properties of Low Friction Zwitterionic Hydrogel Blends
E. D. Lindberg*1, A. O. Osaheni1, M. M. Blum1, P. T. Mather2, 1Syracuse University, Syracuse, NY, 2Bucknell University, Lewisburg, PA

1002. - Withdrawn

1003. Biocompatibility Evaluation of Electrospun Gelatin Nanofiber Scaffolds in Calvarial Defect Mouse Model
B. Montano*1, M. Khanal2, L. S. Nair2, C. T. Laurencin2, 1University of Texas At El Paso, El Paso, TX, 2University of Connecticut Health, Farmington, CT

1004. Mechanical Evaluation of a Novel Composite Material for Meniscus Replacement
A. O. Inyang*, C. L. Vaughan, University of Cape Town, Cape Town, South Africa

1005. The Interaction of Threads and Implant Microtopography on Implant Resistance to Reverse Torque
R. S. Liddell*1, E. Ajami2, E. Bajenova1, Y. Li1, Y. Yang1, J. E. Davies1, 1University of Toronto, Toronto, ON, 2Zimmer Biomet, Palm Beach Gardens, FL

1006. Calcified and Silicified Collagen Scaffolds Fabricated Using Dual-Functional Non-Collagenous Protein Analog
C. Hu*, M. Wei, University of Connecticut, Storrs, CT

1007. Effect of Sintering Time on Mechanical Properties of Porous Ti-6Al-4V Implant
W. Soboyejo, Princeton University, Olden Street, NJ

UHMWPE, is it good enough?

1008. Effect of Presoak Conditions and Load Soak Control Temperature on UHMWPE Sorption
J. T. Henderson*, C. Wise, E. Hippensteel, J. Langhorn, DePuy Synthes Joint Reconstruction, Warsaw, IN

Ophthalmic Biomaterials SIG

1009. Surface Treatment of Silicone Materials
C. B. Hu*, D. Pham, M. D. Lowery, Abbott Medical Optics, Santa Ana, CA

1010. Development of a Topical Ophthalmic Biomaterial for the Controlled Release of Cysteamine
J. Jimenez*1, M. A. Washington1, K. K. Nischal2, M. V. Fedorchak1,2, 1University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh School of Medicine, Pittsburgh, PA

1011. Biomimetic Materials for Ocular Surface Repair
L. Costella*1, M. Patterson1, R. Redmond2, A. Eiseman3, C. Tison1, 1Luna Innovations Incorporated, Charlottesville, VA, 2Massachusetts General Hospital, Boston, MA, 3Medical University of South Carolina, Charleston, SC

1012. Surface Modification of Model Contact Lenses with Wetting and Lubricating Agents for Improved Ocular Compatibility
M. Korogiannaki*1, M. Samsom2, T. Schmidt3, H. Sheardown1, 1McMaster University, Hamilton, ON, 2University of Calgary, Calgary, AB, 3University of Alberta, Calgary, AB

1013. Shrink Wrapping Cells in ECM Protein Nano-Scaffolds for Repair of the Corneal Endothelium
R. N. Palchesko*, A. W. Feinberg, Carnegie Mellon University, Pittsburgh, PA

1014. Regeneration Permissive Retinal ECM as Vehicle for Retinal Progenitor Cell Delivery
J. Kundu*1, P. Baranov2, J. Monaghan1, M. Young2, R. Carrier1, 1Northeastern University, Boston, MA, 2Schepens Eye Research Institute, Boston, MA

1015. PAMAM Dendrimers for Improved Timolol Delivery
M. G. Lancina*, J. Wang, H. Yang, Virginia Commonwealth University, Richmond, VA

1016. Improving Silicone Elastomer Hydrophilicity with Hyaluronan
R. L. Koch*, S. P. James, D. A. Prawel, Colorado State University, Fort Collins, CO

1017. Tissue Derived Extracellular Matrix stabilizes corneal biomechanics and ultrastructure
X. Wang*1, H. Yin2, S. Majumdar1, J. Sohn1, W. Stark3, J. Elisseeff1, 1Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 2West China Hospital, Sichuan University., Sichuan, China, 3Johns Hopkins University, School of Medicine, Baltimore, MD

Cardiovascular Biomaterials SIG

Acellular Biomaterials for Myocardial Repair

1018. Decellularization of Ureter as a New Scaffold for Small Vascular Vessel in Rabit
Y. Myung*, C. Pak, Seoul National University Bundang Hospital, seoung nam si, Republic of Korea

1019. Directing the Mobilization and Homing of Stem Cells for Cardiac Repair
E. Mulvany*1, J. Wu2, Y. Hong2, G. Zhang1, 1The University of Akron, Akron, OH, 2The University of Texas at Arlington, Arlington, TX

1020. An Injectable Sulfonated Reversible Thermal Gel for Therapeutic Angiogenesis to Promote the Recovery of Cardiac Function After a Myocardial Infarction
D. J. Lee*, M. Cavasin, A. Rocker, D. Park, University of Colorado Denver | Anschutz Medical Campus, Aurora, CO

Biomaterials for Cardiovascular Regeneration

1021. Versatile Extracellular Matrix Immobilization on a Metal Stent for Outgrowth Endothelial Cell Delivery
M. J. Jeong1, K.-S. Park1, I. H. Kim2, H. B. Kim3, K. S. Lim3, Y. J. Hong3, Y. K. Joung1, D. K. Han*1, 1Korea Institute of Science and Technology, Seoul, Republic of Korea, 2Korea university, Seoul, Republic of Korea, 3The Heart Center of Chonnam National University Hospital, Gwangju, Republic of Korea

1022. PEGylated Chitosan Graft for Blood Vessel Repairation
A. Yin*, Y. Wang, X. Zhang, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China

1023. Myocardial Extracellular Matrix Impregnated with Synthetic Cardiac Stem Cells for Cardiac Regeneration
J. Tang1, K. Cheng1,2, D. Freytes3, E. Wrona3, 1North Carolina State University, Raleigh, Zhengzhou, China, 2University of North Carolina at Chapel Hill, Raleigh, NC, 3NC State/ UNC-Chapel Hill, Raleigh, NC

1024. Development of Hyaluronan-Based Microrods for the Attenuation of Chronic Cardiac Fibrosis
L. V. Le*1, Q. Fang1, R. E. Sievers1, M. Mkrtschjan2, B. Russell2, R. J. Lee1, T. A. Desai1, 1University of California, San Francisco, San Francisco, CA, 2University of Illinois at Chicago, Chicago, IL

1025. Evaluation of an Injectable Polymeric Delivery System for Controlled and Localized Release of Biological Factors to Promote Therapeutic Angiogenesis
A. J. Rocker*, D. J. Lee, D. Park, University of Colorado Denver | Anschutz Medical Campus, Aurora, CO

1026. Antithrombotic Polyurethane Materials with Tunable Mechanical Properties for Vascular Grafts
A. M. Stahl*, Y. Yang, Stanford University, Stanford, CA

Cardiovascular Biomaterials

1027. Conjugating Chondroitin Sulfate on Amine-rich Surface: Towards Better Multi-Functions for Cardiovascular Implanted Biomaterials
J. Li*, K. Zhang, Zhengzhou University, Zhengzhou, China

1028. Polyhydroxyalkanotes, Potential New Materials for Cardiac Tissue Engineering
I. Roy*1, P. Dubey1, E. Humphrey2, C. Terracciano2, S. Harding2, 1University of Westminster, London, United Kingdom, 2Imperial College London, London, United Kingdom

1029. Novel Non-thrombogenic/Non-fouling Thermoplastic Polyurethanes for Cardiovascular Devices
R. W. Day*, M. J. Wiggins, R. Woofter, K. Smith, U. Makal, W. Qaqish, H. Zhang, Lubrizol Corporation, Brecksville, OH

1030. Enhancing Expanded Polytetrafluoroethylene with Hyaluronan for Small Diameter Vascular Graft Applications
H. Bui*, D. Prawel, S. James, Colorado State University, Fort Collins, CO

1031. Trans-catheter cardiovascular surgery: how crimping can affect the durability of the implants
B. Chenesseau1, F. Heim*2, N. Chakfe1, 1Geprovas, Strasbourg, France, 2Université de Haute Alsace / Laboratoire de Physique et Mécanique Textiles, Mulhouse, France

1032. Zirconia-Polyurethane Aneurysm Clip for Reducing Susceptibility Artifact in Magnetic Resonance Imaging
K. Cho*1, T. Jang1, H. Kim1, J. Sun1, W. Cho2, J. Kim2, E. Ha2, H. Kang2, S. Choi2, Y. Son3, 1Seoul National University, Seoul, Republic of Korea, 2Seoul National University College of Medicine, Seoul, Republic of Korea, 3Seoul National University Boramae Hospital, Seoul, Republic of Korea

1033. Hydrogen peroxide-responsive antioxidant polymeric prodrugs as on demand therapeutics for cardiac injury
C. Kang*1, P. M. Kang2, D. Lee1, 1Chonbuk National University, Jeonju, Republic of Korea, 2Harvard Medical School, Boston, MA

1034. Multi-layered Vascular Grafts with Improved Compliance Matching and Suturability for Long Term Patency
A. Post*1, A. Kishan1, M. Hahn2, E. Cosgriff-Hernandez1, 1Texas A&M University, Houston, TX, 2Rensselaer Polytechnic Institute, Troy, NY

1035. Development of a collagen-matrigel scaffolds for studying heat valve mechanobiology
N. T. LAM*1, H. N. LAM2, N. Sturdivant1, K. Balachandran1, 1University of Arkansas, Fayetteville, AR, 2University of California, Santa Cruz, CA

1036. Differential responses of healthy and type II diabetic endothelial cells on topography
M. F. A. Cutiongco1, B. M. X. Chua1, D. N. J. Neo1, E. K. F. Yim*2, 1National University of Singapore, Singapore, Singapore, 2University of Waterloo, Waterloo, ON

1037. Fabrication of Human Serum Albumin film on expanded polytetrafluoroethylene (e-PTFE) for Enhanced Hemocompatibility and Adhesion Strength
A. Khanna*1, I. Luzinov1, F. Vatansever2, R. Burtovvy1, E. M. Langan3, M. LaBerge1, 1Clemson University, Clemson, SC, 2Kimberly Clark, Clemson, SC, 3Greenville Health System (GHS), Greenville,, SC

1038. A Novel Tri-Component Polymeric Electrospun Scaffold for Vascular Tissue Engineering
V. Ramaswamy, T. R. Repetto*, J. B. Allen, University of Florida, Gainesville, FL

Irradiation of Biomaterials: Recent Development

1039. Impact of Radiation Sterilization on the Degradation Behavior of Poly(lactic acid) (PLA) Tubing for Absorbable Cardiovascular Stents
C. Tissot, J. Guo*, U.S. Food and Drug Administration, Silver Spring, MD

Biomaterials Education SIG

Broadening Participation in Engineering

1040. Improving Scientific Communication of Undergraduates through Peer Evaluation
C. LS Simpson*, Mississippi State University, Mississippi State, MS

1041. - Withdrawn