Design, Fabrication and Characterization of Multiscale and Multifunctional Biomaterials 1


Design, Fabrication and Characterization of Multiscale and Multifunctional Biomaterials: The ability to engineer biomaterials at the molecular, micro and macro scales provides new opportunities to design and fabricate multiscale systems that can interact with cells and tissues by integrating physical, mechanical and chemical mechanisms. This session welcomes submissions focused on new design strategies for these types of biomaterials, novel fabrication approaches from the nano to micro to macro scales, and methods used to characterize cell and tissue response.


  • 2:30 p.m. 177. Exploring the potential of multifilament electrospun sutures for soft tissue repair, P.-A. Mouthuy*(1), R. Abhari(2), A. Lach(2), S. Dakin(2), A. Carr(2), (1)Oxford University, Oxford, United Kingdom, (2)University of Oxford, Oxford, United Kingdom

  • 2:45 p.m. 178. A comparison between electro and rotary-jet spinning to produce micro/nano-fibers of different concentrations of polycaprolactone, M. Machado de Paula*(1), F. Roberta Marciano(2), T. J. Webster(3), A. de Oliveira Lobo(2), (1)Northeastern University, Cambridge, MA, (2)Laboratory of Biomedical Nanotechnology, Development Research Institute, University of Vale do Paraiba, Brazil, SJ dos

  • 3:00 p.m. 179. Development of Multifunctional Shear-thinning Guest-host Assembled Colloidal Hydrogels, J. Mealy*, H.-H. Jeong, D. Lee, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

  • 3:15 p.m. 180. Chromonic Liquid Crystal Hydrogels as Anisotropic, Active Biomaterials, T. H. Ware*, R. S. Kularatne, J. M. Boothby, B. J. Black, J. J. Pancrazio, The University of Texas at Dallas, Richardson, TX

  • 3:30 p.m. 181. Designing high-water-content and resilient PEG-based hydrogels, Y. Zhang*, D. An, W. Song, Y. Pardo, Q. Liu, M. Ma, Cornell University, Ithaca, NY

  • 3:45 p.m. 182. Engineering Anisotropic Janus-type Polymer Nanofiber Scaffolds via Centrifugal Jet Spinning, P. Ravishankar*, A. Khang, K. Balachandran, University of Arkansas, Fayetteville, AR

  • 4:00 p.m. 183. Capillary Forces and Multiscale Porosity Synergistically Enhance Osteointegration in Biphasic Calcium Phosphate Scaffolds, A. Wagoner Johnson*(1), L. E. Rustom(1), T. Boudou(2), S. Lou(3), I. Pignot-Paintrand(4), B. W. Nemke(5), Y. Lu(5), M. D. Markel(5), C. Picart(2), (1)University of Illinois at Urbana-Champaign, Urbana, IL, (2)University of Grenoble Alpes and CNRS UMR, Gre

  • 4:15 p.m. 184. Profiling a Prophylactic Local Triple Therapy Hydrogel Patch to Treat and Prevent Cancer Recurrence, J. Conde(1), N. Oliva(2), E. Yi. Zhang(2), (1)MIT, Boston, MA, (2)MIT, Cambridge, MA

Cardiovascular Biomaterials


  • 2:30 p.m. 169. Fabricating And Tuning An Elastomeric Blood Vessel For Use In Coronary Artery Bypass Surgeries, H. J. Warner*, W. D. Wagner, Wake Forest University School of Medicine, Winston-Salem, NC

  • 2:45 p.m. 170. Human iPSC-derived Cardiomyocyte Response to 3D Fetal and Adult Decellularized Hearts, A. C. Silva*(1), T. A. Hookway(2), D. S. Nascimento(1), P. Pinto-do-Ó(1), T. C. McDevitt(2,3), (1)Universidade do Porto, Porto, Portugal, (2)Gladstone Institutes, San Francisco, CA, (3)University of California, San Francisco, CA

  • 3:00 p.m. 171. Elucidating Endothelial Cell Hemostatic Regulation by Isolating Integrin-mediated Adhesion to Bioactive Hydrogels, A. Post*(1), M. Martinez-Moczygemba(2), E. Cosgriff-Hernandez(1), (1)Texas A&M University, Houston, TX, (2)Texas A&M Health Science Center, Houston, TX

  • 3:15 p.m. 172. In Vivo Anastomosis and Perfusion of a 3D Printed PEG Hydrogel Containing Microvascular Networks, S. J. Paulsen*(1), C. W. Chen(2), B. Grigoryan(1), N. J. Calafat(1), P. Atluri(2), J. S. Miller(1), (1)Rice University, Houston, TX, (2)University of Pennsylvania, Philadelphia, PA

  • 3:30 p.m. 173. Efficient Aortic Valve Cell Seeding into Decellularized Pericardial Membrane: Advancements into Manufacture of Engineered Valve Tissue for the Desing of ‘off the shelf’, Living, Valve Bioimplants, F. Amadeo, M. Agrifoglio, G. Polvani, M. Pesce, R. Santoro*, Centro Cardiologico Monzino, Milan, Italy

  • 3:45 p.m. 174. Impact of Peritoneal Pre-conditioning on Tissue Engineered Vascular Graft Intimal Hyperplasia and Inflammation, M. Shojaee, K. B. Wood, K. Vuppuluri, L. K. Moore, C. A. Bashur*, Florida Institute of Technology, Melbourne, FL

  • 4:00 p.m. 175. Rapid Fabrication of Injectable Engineered Cardiac Tissue Spheroids Using a Novel Microfluidic Device, F. B. Finklea*, P. Kerscher, W. J. Seeto, E. A. Lipke, Auburn University, Auburn University, AL

  • 4:15 p.m. 176. Shape-Specific Nanoceria Alleviate Oxidative Stress In Patient-Derived Valvular Interstitial Cells, Y. Xue*, V. Sant, J. Phillippi, S. Sant, University of Pittsburgh, Pittsburgh, PA

Thought Leader Symposium - Frederick J. Schoen, MD, PhD: Understanding, Reacting to, and Preventing Medical Device Failure


Invited Speaker(s)

  • Frederick J. Schoen, MD, PhD
  • Richard Bianco
  • Cynthia Claque
  • Ann Graves
  • Stuart Goodman, MD, PhD

Orthopaedic Biomaterials 3


  • 2:30 p.m. 193. Invited Speaker: Cato Laurencin, MD, PhD

  • 3:00 p.m. 195. Tribocorrosion Heredity Integral Modeling of Abrasion-Current-Impedance-Voltage Relationships, J. L. Gilbert*(1), L. Zhe(2), D. Zhu(1), G. W. Kubacki(1), (1)Syracuse Biomaterials Institute, Syracuse, NY, (2)Trauson (China) Medical Instrument Co., Ltd, Changzhou, China

  • 3:15 p.m. 196. Silk-Reinforced Biomaterials for Load-Bearing Fixation Devices, B. Heimbach*(1), D. Zhang(1), M. Wei(2), (1)University of Connecticut, Storrs, CT, (2)Department of Material Science and Engineering, Storrs, CT

  • 3:30 p.m. 197. Combinatorial hydrogels for deciphering the role of cell-hydrogel interactions on MSC chondrogenesis, S. L. Vega*, K. H. Song, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

  • 3:45 p.m. 198. Remodeling of Settable, Weight-Bearing Polyurethane Composite Bone Grafts in a Tibial Plateau Defect Model in Sheep, M. A. P. McEnery*(1), S. Lu(1), S. M. Shiels(2), D. J. Tennent(2), J. C. Wenke(2), S. A. Guelcher(1), (1)Vanderbilt University, Nashville, TN, (2)United States Army Institute of Surgical Research, JBSA Ft.Sam Houston, TX

  • 4:00 p.m. 199. Bioactive Surface-porous PEKK, X. Zhu, B. Yuan*, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, Chengdu, China

  • 4:15 p.m. 200. Mechanically Assisted Electrochemical Degradation of Alumina-TiC Composite, G. Zhang, H. Maharaja*, Clemson University, Clemson, SC

Invited Speaker(s)

  • Cato T. Laurencin, MD, PhD

Tissue Engineering and Organoid Development


  • 2:30 p.m. 217. Invited Speaker: Linda Griffith, PhD

  • 3:00 p.m. 219. 3D Cardiac Microtissues with Integrated Force Sensors for Non-Invasive Readout of Contractile Force, J. M. Bliley*, R. Duffy, I. Batalov, A. Kalmykov, A. W. Feinberg, Carnegie Mellon University, Pittsburgh, PA

  • 3:15 p.m. 220. Migration-Permissive Hydrogels As Biomimetic Matrices for Human Salivary Gland Engineering, D. A. Harrington*(1), M. Martinez(1), S. Pradhan-Bhatt(2), R. L. Witt(2), M. C. Farach-Carson(3), (1)Rice University, Houston, TX, (2)University of Delaware, Newark, DE, (3)University of Texas Health Science Center at Houston, Houston, TX

  • 3:30 p.m. 221. Cellular inhibition of radical-mediated polymerization of poly(ethylene glycol) hydrogels formed via thiol-norbornene click chemistry, S. Chu*, S. Lalitha Sridhar, M. Schneider, F. Vernerey, S. Bryant, University of Colorado Boulder, Boulder, CO

  • 3:45 p.m. 222. Hydrogel Composition Regulates Chondrogenesis by Mesenchymal Stem Cells and Endochondral Ossification inEngineered Cartilaginous Interfacial Tissues, J. Chen*, A. Donius, J. Taboas, University of Pittsburgh, Pittsburgh, PA

  • 4:00 p.m. 223. Probing Oxygen Tension of Tissue Engineered Grafts Using Oxygen Imaging, M. Kotecha*(1), D. Dorcemus(2), S. Nukavarapu(2), B. Epel(3), H. Halpern(3), (1)University of Illinois at Chicago, Chicago, IL, (2)University of Connecticut, Farmington, CT, (3)The University of Chicago, Chicago, IL

  • 4:15 p.m. 224. Growth Factor Presentation to MSCs within Micro-fiber/Collagen Composites for Ligament Tissue Engineering, D. Gadalla, L. Dahlgren, A. Goldstein*, Virginia Tech, Blacksburg, VA

Invited Speaker(s)

  • Linda Griffith, PhD

*BTI*Panel Discussion: Benchtop to Bedside: We’ll Get You There! - Packaging and Sterilization Methods that Withstand Regulatory Scrutiny


A panel of industry and packaging/sterilization specialists who can take the audience through the considerations of packaging and sterilization for clinical trials and commercial distribution. Discussion of international standards and US-FDA Guidances that can help provide direction to product development, manufacturing, and quality systems. The panel will discuss the advantages and pitfalls of different sterilization methods and validation strategies. The panel will discuss key considerations in determining which sterilization methods to consider based on product. The panel will explore the future directions of packaging and sterilization and how new technology can fit into and break the mold of current practices. The session will start with a 20 minute introduction on the topic, followed by panel discussion and audience interaction


Invited Speaker(s)

  • David Chadwick
  • Elaine Duncan
  • Nicholas J. Christiano/li>

Biomaterials for Therapeutic Drug Delivery 1


Biomaterials for Therapeutic Drug Delivery: Controlled release approaches have the potential to effectively treat a variety of medical conditions, while avoiding complications such as off-site toxicity and drug-resistance. Approaches can include localized, depot-based methods as well as targeted, systemic treatments. Controlled drug delivery can result from affinity interactions, bond cleavage, reservoir or diffusion-based control, and/or stimulus-responsive methodologies. This session will focus on the development of these drug delivery systems, which include nano and microparticles, hydrogels, scaffolds, and thin films, for applications including but not limited to regenerative medicine/tissue engineering, cancer treatments, microbial infections, autoimmune diseases, etc.


  • 2:30 p.m. 161. Continuous Microfluidic Assembly of Biodegradable Poly(beta-amino ester)/DNA Nanoparticles for Enhanced Gene Delivery, J. J. Green*, D. Wilson, A. Mosenia, M. Suprenant, R. Upadhya, D. Routkevitch, R. Meyer, A. Quinones-Hinojosa, Johns Hopkins University, Baltimore, MD

  • 2:45 p.m. 162. Hypoxia and H2O2 Dual-Sensitive Vesicles for Enhanced Glucose-Responsive Insulin Delivery, J. Yu*(1), C. Qian(2), Y. Zhang(1,2), Z. Cui(2), Y. Zhu(2), Q. Shen(3), F. S. Ligler(2), J. B. Buse(4), Z. Gu(1), (1)University of North Carolina at Chapel Hill, Raleigh, NC, (2)North Carolina State University, Raleigh, NC, (3)Nanjing University, Nanjing,

  • 3:00 p.m. 163. A Dynamically Disassembling Filamentous Scaffold for Sustained Micellar Delivery, N. B. Karabin*(1), S. Allen(2), Y.-G. Liu(2), E. A. Scott(2), (1)Northwestern University, Chicago, IL, (2)Northwestern University, Evanston, IL

  • 3:15 p.m. 164. Stimuli sensitive polyurethane-based hydrogels for the controlled and triggered release of anti-inflammatory drugs and anti-bacterial ions., M. Boffito, C. Tonda-Turo, S. Calzone, A. Torchio, G. Ciardelli*, Politecnico di Torino, Turin, Italy

  • 3:30 p.m. 165. Slow, Sustained Release of Corticosteroids from a Polymeric Liquid for Use in Osteoarthritis, E. Rivera-Delgado*, A. Djuhadi, H. von Recum, Case Western Reserve University, Cleveland, OH

  • 3:45 p.m. 166. Imidazole-modified chitosan nanoparticles for delivery to lung epithelial cells in air-liquid interface cultures, B. Lash*, J. Mejías, K. Roy, Georgia Institute of Technology, Atlanta, GA

  • 4:00 p.m. 167. Acid-labile interlocked cyclodextrin polymers for therapeutic applications to rare diseases, A. Tamura*, N. Yui, Tokyo Medical and Dental University, Tokyo, Japan

  • 4:15 p.m. 168. Hydrogels Crosslinked by Photoactive Ruthenium Complex for Rapid Protein Release in Response to Visible Light, C. B. Highley*, T. L. Rapp, I. J. Dmochowski, J. A. Burdick, University of Pennsylvania, Philadelphia, PA

Engineered Biomaterials for Neural Applications 1


Engineered biomaterials for neural applications: Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.


  • 2:30 p.m. 185. Invited Speaker: Hai-Quan Mao, PhD

  • 3:00 p.m. 187. Blood-brain-barrier disruption dictates nanoparticle accumulation following brain injury, V. N. Bharadwaj*(1), R. K. Rowe(2), J. Harrison(2), C. Wu(2), T. R. Anderson(2), J. Lifshitz(2), P. D. Adelson(3), V. D. Kodibagkar(1), S. E. Stabenfeldt(1), (1)Arizona State University, Tempe, AZ, (2)University of Arizona, College of Medicine-Phoenix, Ph

  • 3:15 p.m. 188. Particle hydrogels lead to dramatic decrease in gliosis and promote NPC migration after stroke, E. Sideris*, L. Nih, S. T. Carmichael, T. Segura, University of California, Los Angeles, Los Angeles, CA

  • 3:30 p.m. 189. Oligodendrocyte Survival, Proliferation, and Intracellular Redox State is Dependent on 3D Hydrogel Mechanics and Degradation, L. N. Russell, K. J. Lampe*, University of Virginia, Charlottesville, VA

  • 3:45 p.m. 190. Astrocyte Extracellular Matrix Incorporation Improves Neurite Growth on Hyaluronic Acid Hydrogels, R. E. Thompson*(1), L. Crawford(2), S. Sakiyama-Elbert(1), (1)University of Texas-Austin, Austin, TX, (2)Washington University in St Louis, St Louis, MO

  • 4:00 p.m. 191. Directing Neuron and Glial Response Utilizing Surface Chemistry, Topography and Electrical Stimulation, K. M. Pawelec*(1), Y. Koffler(2), M. Tuszynski(2), W. Campana(2), J. Sakamoto(1), (1)University of Michigan, Ann Arbor, MI, (2)University of California San Diego, La Jolla, CA

  • 4:15 p.m. 192. CNTs nanostructured scaffolds: a potential way to tune neural network, I. Rago*(1), L. Cozzarini(2), R. Rauti(3), A. Goldoni(2), L. Casalis(2), L. Ballerini(3), D. Scaini(3), (1)University of Trieste, Trieste, Italy, (2)ELETTRA Synchrotron Light Source, Trieste, Italy, (3)International School for Advanced Studies (SISSA), Trieste, Italy

Invited Speaker(s)

  • Hai-Quan Mao, PhD