About

Regenerative Engineering: A Look To The Year 2027: We define Regenerative Engineering as a Convergence of Advanced Materials Science, Stem Cell Science, Physics, Developmental Biology, and Clinical Translation. We believe that an “un-siloed’ technology approach will be important in the future to realize grand challenges such as limb and organ regeneration. We also believe that biomaterials will play a key role in achieving overall translational goals. Through convergence of a number of technologies, with advanced materials science playing an important role, we believe the prospect of engaging future grand challenges is possible. The theme for this Thought Leader Symposium can be described as 2027: Where can we be and how will we get there? The symposium is a futuristic look at where Regenerative Engineering can take us towards solving grand challenges, and how their work will play a role. The session will be forward looking in scope and involve Senior Thought Leaders and Emerging Thought Leaders providing insight and interchange.

Invited Speaker(s)

Yusuf Khan, PhD
Meng Deng, PhD
MaCalus Hogan, PhD
Michael Yaszemski, MD, PhD

Cancer Nanotechnology

About

Cancer Nanotechnology: The cellular and therapeutic aspects of nanotechnology as it applies to the cancer microenvironment will be covered under this session. The biomaterial interface is applicable towards the cell and the therapeutic. The session would solicit abstracts from the biomaterial community working on the nano and microenvironment combinations as it applies to cancer.

Abstracts

5:00 p.m. 237. Invited Speaker: Jon Dobson, PhD - IJN Distinguished Scientist
5:15 p.m. 238. Hyaluronate Conjugated Molybdenum Disulfide for Photoacoustic Cancer Theranosis, MH. Shin*, S. K. Hahn, Pohang university of science and technology (POSTECH), Pohang, Republic of Korea
5:30 p.m. 239. Development of Targeted Micellar Nanotheranostics for Metastatic Breast Cancer, A. Manigandan*, V. Handi, N. S. Sundaramoorthy, J. Radhakrishnan, R. Dhandapani, S. Sethuraman, A. Subramanian, SASTRA University, Thanjavur, India
5:45 p.m. 240. In Vitro Breast Tumor Model to Investigate the Role of Tumor Microenvironment in Disease Progression, A. Daverey, A. Drain, S. Kidambi*, University of Nebraska-Lincoln, Lincoln, NE
6:00 p.m. 241. A semi-automated microfluidic platform for real-time tracking of cancer cells and investigation of nanoparticles cellular uptake, M. R. Carvalho*(1), F. R. Maia(1), J. Silva-Correia(1), B. Costa(2), R. L. Reis(1), J. M. Oliveira(1), (1)3B's Research Group, Guimarães, Portugal, (2)Life and Health Sciences Research Institute (ICVS), Braga, Portugal
6:15 p.m. 242. Dual Delivery Nanoscale Device for miR-345 and Gemcitabine Co-Delivery to Treat Pancreatic Cancer, M. Uz*(1), S. Rachagani(2), S. Batra(2), S. Mallapragada(1), (1)Iowa State University, Ames, IA, (2)University of Nebraska Medical Center, Omaha, NE

Invited Speaker(s)

Jon Dobson, PhD

Multifunctional Biomaterial Design for Regenerative Tissue Engineering

About

Multifunctional Biomaterial Design for Regenerative Tissue Engineering: Multifunctional biomaterials which can integrate multiple functions either through molecular design or through hierarchical assembly of structures at different length scales within a single system can synergize cellular functions in a spatiotemporal manner are an essential requirement for regenerative tissue engineering. This session will address the development of novel biomaterials where multiple functionalities e.g. cell signaling/sensing, cellular morphogenesis, biodegradability, matrix remodeling are regulated independently or interdependently during tissue regeneration. Emphasis of the session will be on the design principles and synthesis and fabrication methods for building materials with macro-, micro-, or nano-structured components to regulate multiple functions

Abstracts

5:00 p.m. 249. Hydroxyapatite coated microribbon-based hydrogels induce robust osteogenesis and mineralization of mesenchymal stem cells in 3D, B. Conrad*, X. Tong, F. Yang, Stanford University, Stanford, CA
5:15 p.m. 250. Production of Contractile Muscle Tissue Constructs Based on Cell Sheet Tissue Engineering, H. Takahashi*, T. Shimizu, M. Yamato, T. Okano, Tokyo Women's Medical University, Tokyo, Japan
5:30 p.m. 251. Intrafibrillarly-mineralized and antimicrobial elastin-like scaffold for endodontic applications, C. Aparicio*(1), C. Lan(1), Y. Li(1), J. C. Rodriguez-Cabello(2), (1)University of Minnesota, MInneapolis, MN, (2)University of Valldolid, Valladolid, Spain
5:45 p.m. 252. A High Throughput Peptide Microarray Platform for Probing Cellular Behavior in 3-D, S. Sharma*, M. Floren, W. Tan, S. Bryant, University of Colorado Boulder, Boulder, CO
6:00 p.m. 253. Tri-Crosslinking of Alginate-Based Supramolecular Hydrogels for Cartilage Regeneration, J. N. Etter(1), Rachael A. Oldinski(1,2), (1)University of Vermont, Burlington, VT (2)University of Vermont, Larner College of Medicine, Burlington VT
6:15 p.m. 254. Ex vivo Study of Nanowires in Mini-guts, Y. Qi*, Iowa State University, Ames, IA

3D Printing and its Impact on Biomedicine

About

3D Printing and its Impact on Biomedicine: A future where medical treatment has become on-demand, highly personalized, with treatments that are patient specific, not ‘one size fits all’, is now being realized. Such a future requires a technology with increased specificity, tunability, and is customizable. Recent advances in 3D printing (medical devices, drugs) and bioprinting (microcontact, inkjet etc.) may enable anywhere on-demand medical treatment, and bring us closer to achieving this future. Recent advances in 3D printing are now being adapted for the rapid printing of medicines, artificial devices and prosthetics, and even human tissue. In sum, we are still at the early stage of a major technology revolution in biomedicine, with 3D printing applications expanding at yearly rates that draw parallels with the personal computer revolution of the 1980 or introduction of the cell phone in the 1990’s. This symposium will feature the latest advancements in 3D printing with a special emphasis on biomedical applications.

Abstracts

5:00 p.m. 225. Hydrocolloid Inks for Solid Freeform Fabrication of Porous Hydrogel Constructs, K. A. Gold*, N. A. Sears, S. Cereceres, E. M. Cosgriff-Hernandez, Texas A&M University, College Station, TX
5:15 p.m. 226. Fabrication of a bioengineered 3D printed calciumalkaliphosphate-based bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro, D. Adel-Khattab(1), F. Giacomini(2), B. Peleska(2), R. Gildenhaar(3), G. Berger(3), C. Gomes(3), U. Linow(3), M. Hardt(4), J. Guenster(3), A. Houshmand(2), M. Stiller(2), K. Abdel Ghaffar(5), A. Gamal(5), M. EL-Mofty(5), C. Knabe*(6), (1)Ain Shams Univers
5:30 p.m. 227. Photocurable Bioinks for Inkjet 3D Pharming of Hydrophilic Drugs, C. S. Linsley*, G. F. Acosta-Vélez, B. M. Wu, University of California, Los Angeles, Los Angeles, CA
5:45 p.m. 228. Osteoblast Functions of Bioactive 3D Printed Interconnected Porous Ti-6Al-4V Mesh Structures, K. Nune*(1), D. Misra(1), S. Li(2), (1)University of Texas at El Paso, El Paso, TX, (2)Chinese Academy of Sciences, Shenyang, China
6:00 p.m. 229. 3D Printing of Tissue Engineering Scaffolds with “On-the-Fly” Adjustment of Filament Diameter, A. Hrynevich, B. ?en Elçi, G. Hochleitner, J. Groll, P. D. Dalton*, University of Wuerzburg, Wuerzburg, Germany
6:15 p.m. 230. A mechanically stiff 3D printed structure combined with a chondrogenic hydrogel for cartilage defect repair, E. Aisenbrey*, A. Tomaschke, C. Fiedler, C. Pascual-Garrido, V. Ferguson, R. McLeod, S. J. Bryant, University of Colorado, Boulder, CO

Surface Characterization and Modification

Abstracts

5:00 p.m. 267. Crosslinking-dependent morphology, lubricity and mechanics of PVP gel coatings characterized by AFM, G. Haugstad*(1), K. Wormuth(1), M. Zeng(2), C. Colling(1), A. McCormick(1), (1)University of Minnesota, Minneapolis, MN, (2)Boston Scientific Corp., Maple Grove, MN
5:15 p.m. 268. Investigating the degradation of alkanethiol self-assembled monolayer surfaces in mesenchymal stem cell culture, B. Almeida, A. Shukla*, Brown University, Providence, RI
5:30 p.m. 269. Melt Blended Phase Separated Polyethylene-b-Polyethylene and Polypropylene Blends for Enhanced Anti-Fouling: Effect of Polyethylene Glycol Chain Length and Surface Density on Protein Adsorption, A. Garle*(1), B. Budhlall(2), (1)University of Massachusetts, Lowell, Rochester, MN, (2)University of Massachusetts, Lowell, Lowell, MA
5:45 p.m. 270. Selective capture of regulatory T cells for cancer immunotherapy, T. Kimura*(1), N. Nakamura(1), Y. Hashimoto(1), S. Sakaguchi(2), S. Kimura(3), A. Kishida(1), (1)Tokyo Medical and Dental Univeristy, Tokyo, Japan, (2)Osaka University, Osaka, Japan, (3)Kyoto University, Kyoto, Japan
6:00 p.m. 271. Biomineralizated diamond-like carbon films with titanium dioxide - study on Staphylococcus aureus biofilm, F. S. Lopes(1), J. R. Oliveira(2), J. Milani(1), L. D. Oliveira(2), J. P. B. Machado(3), V. J. Trava-Airoldi(3), A. O. Lobo(1), F. R. Marciano*(1), (1)University of Vale do Paraíba, Sao Jose Campos, Brazil, (2)Paulista State University, Sao Jose Campos, B
6:15 p.m. 272. Texture and microstructure development in hydroxyapatite coatings deposited by means of RF-magnetron sputtering, A. A. Ivanova*(1), M. A. Surmeneva(1), R. A. Surmenev(1), D. Depla(2), (1)National Research Tomsk Polytechnic University, Tomsk, Russian Federation, (2)Ghent University, Ghent, Belgium

Biomaterials for Therapeutic Drug Delivery 2

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Biomaterials for Therapeutic Drug Delivery: Controlled release approaches have the potential to effectively treat a variety of medical conditions, while avoiding complications such as off-site toxicity and drug-resistance. Approaches can include localized, depot-based methods as well as targeted, systemic treatments. Controlled drug delivery can result from affinity interactions, bond cleavage, reservoir or diffusion-based control, and/or stimulus-responsive methodologies. This session will focus on the development of these drug delivery systems, which include nano and microparticles, hydrogels, scaffolds, and thin films, for applications including but not limited to regenerative medicine/tissue engineering, cancer treatments, microbial infections, autoimmune diseases, etc.

Abstracts

5:00 p.m. 231. Degradable poly(ethylene glycol) (PEG) hydrogels to temporally control delivery of siRNA therapeutics, Y. Wang*, S. Zhang, D. S. W. Benoit, University of Rochester, Rochester, NY
5:15 p.m. 232. Effect of PDGF-BB Delivery from Heparinized Collagen Sutures on Healing of Lacerated Flexor Tendon In-vivo, M. Younesi*, D. M. Knapik, J. Cumsky, B. O. Donmez, P. He, A. Islam, G. Learn, M. Bohl, R. J. Gillespie, O. Akkus, Case Western Reserve University, Cleveland, OH
5:30 p.m. 233. Zwitterionic Cryogels for Sustained Release of Proteins, G. Sener*, M. D. Krebs, Colorado School of Mines, Golden, CO
5:45 p.m. 234. Dynamically crosslinked hyaluronic acid hydrogels for insulin delivery, K. Xue*, MIT, Cambridge, MA
6:00 p.m. 235. Intracellular Delivery of Antibody by Self-Assembled Protein Nanoparticles, S. I. Lin, C. Lukianov, J. Champion*, Georgia Institute of Technology, Atlanta, GA
6:15 p.m. 236. Composition of Extracellular Matrix Protein Based Composites Affects rhBMP-2 Release, Q. C. Nguyen, A. V. Janorkar*, University of Mississippi Medical Center, Jackson, MS

Immunomodulation 2

Abstracts

5:00 p.m. 243. Macrophage-targeted Drug Delivery System for the Treatment of Rheumatoid Arthritis, A. Pentecost*(1), M. Kim(2), S. Jeon(2), Y. Gogotsi(1), K. Kim(2), K. Spiller(1), (1)Drexel University, Philadelphia, PA, (2)Korea Institute of Science and Technology, Seoul, Republic of Korea
5:15 p.m. 244. Combination Nanovaccine provides protection against Influenza in aged mice, R. Darling, K. Ross*, S. Senapati, J. Alley, M. Jefferson, M. Kohut, M. Wannemeuhler, S. Mallapragada, B. Narasimhan, Iowa State University, Ames, IA
5:30 p.m. 245. Displaying Anti-Neutrophil Antibodies at the Host-Skin Graft Interface using IgG-Binding Injectable Fibrils, W. Liu*(1), Y. Wang(1), N. Pham(1), Y. Fan(2), E. Gawalt(1), N. Giannoukakis(2), W. Meng(1), (1)Duquesne University, Pittsburgh, PA, (2)Allegheny Health Network, Pittsburgh, PA
5:45 p.m. 246. Peptide-Loaded Nanoparticles Reduce Positive Co-stimulatory Expression and Induce Antigen-Specific Tolerance, R. Kuo*(1), E. Saito(1), S. D. Miller(2), L. D. Shea(1), (1)University of Michigan, Ann Arbor, MI, (2)Northwestern University, Chicago, IL
6:00 p.m. 247. Evaluation of Immunomodulatory Biomaterial in Zebrafish, C. E. Witherel*(1), J. D. Collin(2), D. Gurevich(3), P. Martin(3), K. L. Spiller(1), (1)Drexel University, Philadelphia, PA, (2)University Hospitals Bristol NHS Trust, Bristol, United Kingdom, (3)University of Bristol, Bristol, United Kingdom
6:15 p.m. 248. Enhancing the Delivery of Therapeutic Antibodies to Tumor Draining Lymph Nodes via Lymphatic-draining Poly(propylene sulfide) Nanoparticles for Cancer Immunotherapy, D. M. Francis*, A. Schudel, N. A. Rohner, S. N. Thomas, Georgia Institute of Technology, Atlanta, GA

Thought Leader Symposium - Cato Laurencin, MD, PhD: Regenerative Engineering

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Abstracts

Invited Speaker(s)

Cancer Nanotechnology

About

Abstracts

Invited Speaker(s)

Multifunctional Biomaterial Design for Regenerative Tissue Engineering

About

Abstracts

3D Printing and its Impact on Biomedicine

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Abstracts

Surface Characterization and Modification

Abstracts

Biomaterials for Therapeutic Drug Delivery 2

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Abstracts

Immunomodulation 2

Abstracts