Injectable Biomaterials for Delivery of Cell, Gene and Protein Therapy

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Injectable Biomaterials for Delivery of Cell, Gene and Protein Therapy: Injectable biomaterials are becoming increasingly popular for the delivery of therapeutic agents. Therapeutic agents such as cells, genetic materials, and proteins offer the possibility to treat a variety of conditions, and the use of injectable biomaterials provides site-specific delivery and immunoprotection for these encapsulated agents. Overall, both synthetic and naturally derived injectable biomaterials have shown potential in the treatment of conditions such as bone defects, cancer, and myocardial infarction.

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*BTI* Translational Orthopaedic Biomaterials

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Translational Orthopaedic Biomaterials: The research, development, education, and outreach of orthopaedic biomaterials (metal, ceramic, polymer, composite, etc.) are welcome. It is expected that the past, present, and future of orthopaedic biomaterials will be presented by well-respected researchers. Emerging translational orthopaedic biomaterials and related challenges and industrial and government regulations will be discussed. Topics will also include advanced cell culture and animal models for translational orthopaedic biomaterials studies.

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Active Wound Dressings for Advanced Wound Care

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Active Wound Dressings for Advanced Wound Care: Although some biologically active compounds were present in ancient naturally-derived poultices, these dressings mainly provided for protection of the wound bed and exudate absorption. With the emergence of cotton fabric (late 1800’s) and synthetics (1950s), these materials became prevalent in wound treatment; however the dressings were still passive, with mainly protective, absorptive, and non-adherent functions. Research into dressings comprised of alloplastic materials which provided a more-active role in wound healing didn’t begin in earnest until the 1960s, and this still remains an under-explored area today.
Challenging requirements such as rapid hemostasis, wound debridement, exudate management, prevention/management of biofilm infection and chronic wounds, pain suppression as well as patient comfort present unique opportunities for the use of modern Biomaterials and textile structures to develop active wound dressings. This session focuses on the recent developments in various aspects of advanced wound care as well as novel materials and structures for wound dressings.

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Biomaterials for Cardiovascular Regeneration

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Biomaterials for Cardiovascular Regeneration: Cardiovascular disease (CVD) is a major medical problem around the globe. To develop proper treatment strategies for CVD, we must overcome the limitations associated with the i) inability to vascularize synthetic tissues, ii) lack of a renewable cell source, iii), lack of biomaterials that have similar features to the native cardiovascular tissues, and iv) lack of tissue models that can recapitulate the events that occur during cardiovascular healing. In this session, we will include topics ranging from strategies of vascularization of engineered constructs to delivery of small molecules and/or cells, and different fabrication methods for generation of 3D scaffolds. Furthermore, the session will provide examples of using engineered heart tissues to test drugs and therapeutic targets for cardiovascular regeneration. Finally, we will also cover examples for translation of cardiovascular tissue engineering.

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Engineered Biomaterials for Neural Applications 2

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Engineered biomaterials for neural applications: Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.

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Evaluation of Tissue Engineering Constructs

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Evaluation of Tissue Engineering Constructs: Tissue engineering is a multi-disciplinary and growing field of research that involves the development of new biomaterials, cell sources, and advanced drug/factor delivery strategies for the repair and regeneration of lost or damaged tissues and organs. This session will cover the development of new methods to rapidly and effectively evaluate the performance of tissue engineering strategies and constructs in laboratory and pre-clinical settings. Specific areas to be covered include the development and testing of new biological assays, bioreactors, in vitro and in vivo models, organs-on-a-chip, advanced imaging methodologies, and non-invasive tools for in situ monitoring of cell and tissue activity.

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Panel Discussion: Veterinary Bioengineering: Partnering with Clinicians to Translate Biomaterials Technologies

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Lynne Jones, MS, PhD (Moderator)
This panel discussion will provide discourse regarding the application of bioengineering to veterinary medicine, specifically addressing technical goals as well as collaboration challenges and opportunities. The value of clinical-bioengineering collaborations to the classroom setting will also be highlighted. Differences in technical “culture”, expectations, and motivators will be explored in conjunction with discussion of best (and worst!) practices in working across clinical-engineering boundaries. Topics will include animal studies used to characterize the biological response to materials for translation to human medicine as well as for application to animal health. Two collaborating engineer-veterinary clinician teams will overview and discuss their experiences in large and small animal research, including classroom, clinical, and laboratory; the audience is encouraged to participate in lively and frank discussion.

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Tutorial: Navigating funding from the NSF & NIH

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