*BTI* Assays to Evaluate Cell and Tissue Interactions with Biomaterials

501. Protein nanoencapsulation-a novel platform to overcome challenges in the preparation of protein-depot for various therapeutic applications, P. Polley*, R. V., J. Giri; Indian Institute of Technology Hyderabad, Medak, India

502. Myocardial Extracellular Matrix embedded with Synthetic Cardiac Stem Cells for Cardiac Regeneration, K. Huang*, T. Su, J. Tang, E. Rrona, L. Qiao, M. Hensley, D. Freytes, K. Cheng; North Carolina State University, Raleigh, NC

503. Hydroxyapatite (HA) Patterning for Alignment of Endothelial Cells for Vascular Graft Application, I Kang*, M Lee, H Lee, C Park, H Kim; Seoul National University, Seoul, Republic of Korea

504. Biologically active gelatin-based scaffolds for bone tissue engineering in rat calvarial and rat hip defect models, M Echave*(1), P Sanchez, II(1), E Anitua, III(2), J Pedraz, IV(1), G Orive, V(1); (1)University of the Basque Country, Vitoria, Spain; (2)University Institute for Regenerative Medicine and Oral Implantology, Vitoria, Spain

*BTI* Biocompatibility Evaluations - Risk, Tests and New Technology

505. Determining Worst-Case Ni Release in Benchtop Studies of Nitinol, E Sussman*, S Sivan, V Chandrasekar, H Shin, J Weaver, M Di Prima, D Saylor; US Food and Drug Administration, Silver Spring, MD

*BTI* From Conception to Clinical Trial: Examples of Technology Development

506. A Biomimetic Hydrogel Coating Platform to Improve Contact Lens Comfort, K Havenstrite*; Tangible Science, Menlo Park, CA

507. X-Ray Diffraction and Rietveld Quantitative Analysis of Solution Deposited Hydroxyapatite Coatings on  Orthopedic Implants, J Langhorn,R Kasinath*; DePuy Synthes Joint Reconstruction, Warsaw, IN

*BTI* Translating Biomaterials for Regenerative Engineering

508. Bioresorbable Composites: A Microscopic view of Structure-Property-Processing effect(*BTI*), B Prabhu*, M Dadsetan, J Santiago, H Liedtke; Evonik Industries, hoover, AL

509. Development of an Injectable Thermoresponsive Gel Matrix for Comprehensive Ocular Trauma Management, M Washington*, J Yu, M Fedorchak; University of Pittsburgh, Pittsburgh, PA

510. Bacteriophage Encapsulation Reduces Pseudomonas aeruginosa Colonization of Hydrogel Scaffold, J Wroe*,C Johnson,A Garcia; Georgia Institute of Technology, Atlanta, GA

511. Preclinical in vitro and in vivo Assessment of Linear and Branched L-Valine Based Poly(ester urea)s for Soft-tissue Applications, N Dreger*(1), M Wandel(1), L Robinson(1), D Luong(1), C Sondergaard(2), M Hiles(2), C Premanandan(3), M Becker(1); (1)The University of Akron, Akron, OH; (2)Cook Biotech Incorporated, West Lafayette, IN; (3)The Ohio State University, Columbus, OH

512. Micronized Amnion/Chorion Delivery Promotes Mesenchymal Stem Cell Recruitment to the Supraspinatus Muscle After Rotator Cuff Injury, L Anderson*(1), L Tellier(1), A Fallon(2), T Koob(2), J Temenoff(1); (1)Georgia Institute of Technology, Atlanta, GA; (2)MiMedx Group Inc., Marietta, GA

*BTI* Translational Biomaterials Research

513. Textile Engineered Small Diameter Vessels for Vascular Tissue Regeneration, S Lu*(1), T Fukunishi(2), C Smoot(1), C Ong(2), P Gabriele(1), N Hibino(2), J Harris(1); (1)The Secant Group, LLC, Telford, PA, (2)Johns Hopkins Hospital, Baltimore, MD

514. A Clinically Relevant Rabbit Surgical Model of Pelvic Reconstruction to Evaluate the Immune Response to Novel Surgical Materials, A. Iftikhar*(1), A. Nolfi(1), P. Moalli(2), B. Brown(1); (1)McGowan Institute for Regenerative Medicine, Pittsburgh, PA, (2)University of Pittsburgh, Pittsburgh, PA

515. Aged Decellularized Muscle Matrix Negatively Impacts Myogenic Differentiation and Fusion, L. Olson*, M. McClure, M. Rashid, B. Boyan, Z. Schwartz; Virginia Commonwealth University, Richmond, VA

516. Engineering a Highly Elastic and Adhesive Naturally-derived Sealant, N. Annabi*(1), Y. Zhang(2), A. Assmann(2), E. Shirzaei Sani(1), A. Lassaletta(3), G. Cheng(4), B. Dehghani(2), A. Vegh(2), G. Ulises Ruiz-Esparza(2), X. Wang(2), S. Gangadharan(1), A. Weiss(4), A. Khademhosseini(2); (1)Northeastern University, Boston, MA,

3D and Microfluidic Technologies for Immunoengineering

517. Functionalized Microcarriers for Enhanced CAR T Cell Manufacturing, N. Dwarshuis*, H. Wilson, A. Patel, K. Roy; Georgia Institute of Technology, Atlanta, GA

518. Microfluidic System Integrated Contact Lens for Tear Sampling, O Kim, Y Song, J Kim*; Korea Institute of Science and Technology, Seongbuk-gu, Republic of Korea

3D Bioprinting for Medical Applications

519. Printability Analysis Models, P Thayer*, E Rebholz, H Abushall; CELLINK LLC, Blacksburg, VA

520. The Impact of Cells on 3D Printing in Cell-Laden Hydrogel Resins, H. Baker*(1), T. Jain(2), A. Gipsov(1), A. Joy(2), J. Fisher(1), D. Kaplan(3), I. Isayeva(3); (1)University of Maryland, College Park, MD, (2)University of Akron, Akron, OH, (3)United States Food and Drug Administration, Silver Spring, MD

521. Patient-Specific 3D Printed Elastomeric Wearable Medical Devices, S. Abdollahi*, E. Markvicka, C. Majidi, A. Feinberg; Carnegie Mellon University, Pittsburgh, PA

522. Characterization of 3D Printed PEEK Lumbar Interbody Fusion Devices via Fused Filament Fabrication, C. Basgul*, T. Yu, B. Dobson, D. MacDonald, R. Siskey, M. Marcolongo, S. Kurtz; Drexel University, Philadelphia, PA

523. Microchannels Generation using a Rapid Subtractive 3D Printing System for Tissue Vascularization, M. Sameti(1), S. Burtch(1), R. Allado(1), R. Olmstead(2), C. Bashur*(1); (1)Florida Institute of Technology, Melbourne, FL, (2)MEDOPHO, Melbourne, FL

524. Effects of Pore Size in 3D Printed Tissue Scaffolds on Murine Fibroblast Proliferation, N. Chartrain*, J. Cartwright, S. Eubanks, W. Surbey, C. Williams, A. Whittington; Virginia Tech, Blacksburg, VA

525. Bioprinting of 3D Vascular Networks within Cell-Laden Hydrogels, S Ji*, E Almeida, M Guvendiren; New Jersey Institute of Technology, Newark, NJ

526. Precise stacking of 3D-printed cell-laden constructs using a decellularized extracellular matrix-based bioink, G Ahn*(1), K Min(1), M Kim(1), C Kim(1), M Kim(1), W Yun(2), J Shim(2); (1)T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, (2)Korea Polytechnic University, Siheung-Si, Republic of Korea

527. Highly Elastic Biodegradable Hydrogel for Cell Printing, C Xu*(1), C Xu(2), W Lee(3), G Dai(3), Y Hong(1), Y Hong(2); (1)University of Texas at Arlington, Arlington, TX, (2)University of Texas Southwestern Medical Center at Dallas, Dallas, TX, (3)Northeastern University, Boston, MA

528. Bioprinting of Gelatin Hydrogels Reinforced with Cellulose Nanocrystals for Tissue Engineering Applications, S Piluso, W Thielemans, J Patterson*; KU Leuven, Leuven, Belgium

529. Bioink Development for 3D Bioprinting Aortic Heart Valves, A. Nachlas*(1), S. Li(2), M. Davis(1); (1)Georgia Institute of Technology and Emory University, Atlanta, GA, (2)Georgia Institute of Technology, Atlanta, GA

530. In Situ Bioprinting of Bone Tissue Constructs, K Moncal*(1), K Godzik(1), O Mrowczynski(1), E Rizk(1), S Tucker(1), A Do(2), A Salem(2), G Lewis(1), I Ozbolat(1); (1)Pennsylvania State University, University Park, PA, (2)University of Iowa, Iowa City, IA

531. Novel Three-dimensional Bioprinting Systems Using Printable Bioinks, G Ahn*(1), K Min(1), M Kim(1), C Kim(1), S Jin(2), W Yun(2), J Shim(2); (1)T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, (2)Korea Polytechnic University, Siheung-Si, Republic of Korea

532. Immobilization of Fibronectin and Elastin protein Domains in 3D PEG Hydrogels, K Hyland*(1), T Miao(2), R Agarwal(3), A Garcia(1), J Champion(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)University of California at Riverside, Riverside, CA, (3)Indian Institute of Science, Bangalaru, Karnataka, India

533. Enhanced Cell Functions on Graphene Oxide Incorporated 3D Printed Polycaprolactone Scaffolds, N Jayatissa, A Jayasuriya, J Unagolla*; The University of Toledo, Toledo, OH

534. 3D Printed Gelatin Scaffold for Conjunctival Reconstruction, S. Dehghani*; Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran

535. Patient-specific 3D Models Providing a 21st Century Approach to Reconstructive Surgery, H. Liss*(1), S. Maliha(1), J. Bekisz(1), L. Witek(1), A. Humayun(1), K. Khouri(1), S. Raffaelli(1), P. Coelho(1), R. Flores(2); (1)New York University, New York, NY, (2)New York University Langone Medical Center, New York, NY

536. Haptic Assessment of Neurosurgical Model of the Brain and Nerves, M. Cavrak*, E. Keating, V. Sama, M. Navarro, D. Dean, J. Rodriguez-Devora; Clemson University, Clemson, SC

537. Tissue Engineering Test System: Optimization of Bead and Gel Deposition for Layer by Layer Tissue Building with a Biofabricator, J Williams, R Ahn, N Robertson, K Burg, T Burg*; University of Georgia, Athens, GA

538. Assessment of Bioglass Incorporated Collagen Bioinks for 3-D Bioprinting, N Kajave(1),B Bagley(2),D Bagley(2),V Kishore*(1); (1)Florida Institute of Technology, Melbourne, FL;(2)Advanced Biomatrix, Carlsbad, CA

539. In Vivo Evaluation of a Collagen-Based Bioink for 3D-Bioprinting of a Tissue-Engineered Aortic Heart Valve, E Maxson*,B Heidari,D Morse,C Noble,F Franchi,R Khorramirouz,M Young,A Lerman; Mayo Clinic, Rochester, MN

540. 3D Printing of PEG Hydrogel Scaffolds Using Novel Low Toxicity Photoinitiator, M Frishberg*(1), M Lin(2), X Zhao(2), Z Wei(2); (1)JenKem Technology USA, Plano, TX; (2)JenKem Technology Co. Ltd., Beijing, China

Appoaches to Accelerate Development of Novel Dental Biomaterials: Predictive Tools to Characterize Long-Term Durability, Safety and Effectiveness

541. Theaflavins, tea extract from Camellia sinensis, are rapid and effective dentin collagen stabilizer, H Liu, Y Wang*; University of Missouri Kansas City, Kansas City, MO

542. Biomimetic Design of Graded Ceramic Restorative Materials for Enhanced Performance, Y Zhang*; New York University College of Dentistry, New York, NY

543. Lanthanides-Doped Upconversion and Downconversion Hydroxyapatite Nanoparticles for Biomedical Tracking, X. Li*, W. Li; Sichuan University, Chengdu, China

544. Chitosan-Calcium Phosphate Composite Materials As Injectable Self Setting Regenerative Dental Materials, M Osmond*, J Harding, M Krebs; Colorado School of Mines, Golden, CO

545. Investigation of Microbiota Composition and Surface Characteristics of Retrieved Implant Healing Abutments, S. Jain*(1), S. Wheelis(1), W. Huo(1), D. Siddiqui(1), T. Wilson(2), P. Valderrama(2), D. Rodrigues(1); (1)University of Texas at Dallas, Richardson, TX, (2)North Dallas Dental Health, Dallas, TX

Bioactive Glasses and Ceramics

546. In Vitro Evaluation of 34.12SiO2 -17.06MgO-7.94 P2O5- 40.88 CaO  Composition for Orthopedic Applications, P. Kaur*(1), K. Singh(1), A. Yadav(1), R. Kaur(2); (1)Guru Nanak Dev University, Amritsar, India, (2)Panjab University, Chandigarh, India

547. Mineralized Alginate Hydrogels using Marine Carbonates; Synthesis and Tissue Engineering Applications, P Diaz-Rodriguez*(1), P Garcia-Triñanes(2), M Echezarreta-López(3), M Landin(1); (1)University of Santiago de Compostela, Santiago de Compostela, Spain; (2)University of Surrey, Surrey, United Kingdom; (3)University of La Laguna, La Laguna, Spain

Biomaterial Technologies for Hemostasis and Wound Care

548. Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy, Q Hu*, W Sun, H Bomba, Z Gu; University of North Carolina at Chapel Hill and North Carolina State University, raleigh, NC

549. Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa., D Medina Cruz*, T Webster; Northeastern University, Boston, MA

550. Acceleration of Wound Healing and Hemostasis Ability of  New Chitosan-Silica Hybrid Dressing Material, J. Park*(1), S. Jung(2), E. Song(2), B. Kim(3), S. Jung(4), I. Chung(4), H. Kim(2), S. Kim(3); (1)Seoul National University Boramae Hospital, Seoul, Republic of Korea, (2)Seoul National University, Seoul, Republic of Korea, (3)Seoul National University Co

551. Effects of Aging on Degradation of Shape Memory Polymer Foams for Aneurysm Treatment, S Reine*(1), M Monroe(1), K Grant(1), K Balakrishna(1), M Hasan(2), D Maitland(1); (1)Texas A&M, College Sation, TX, (2)Shape Memory Medical Inc., Santa Clara, CA

552. Heparin-chitosan Based Nanoparticles for Wound Healing Antibiotic Delivery, S. Fathollahipour*, N. Leipzig; University of Akron, Akron, OH

553. Fabrication and Characterization of Cellulose-Sodium Carboxymethyl Cellulose based Hydrogels for Biomedical Applications, T. Bambharoliya*(1), R. Vaid(1), S. Zia(2), A. Islam(2), A. Sabir(2), T. Jamil(2), M. King(1); (1)North Carolina State University, Raleigh, NC, (2)University of the Punjab, Lahore, Pakistan

554. Effect of Modulating Crosslink Density on Margination and Biodistribution of Platelet-like Particles, J. Nicosia*(1), D. Chambers(1), M. Harp(2), A. Fernandez-Nieves(1), W. Lam(1), A. Brown(3), T. Barker(2); (1)Georgia Institute of Technology, Atlanta, GA, (2)University of Virginia, Charlottesville, VA, (3)North Carolina State University, Raleigh, GA

555. Characterization of Biocompatible Hydrogel for Wound Healing Applications, J. Kerley*(1), J. Nagatomi(1), T. Konno(2), K. Fukazawa(2), K. Ishihara(2); (1)Clemson University, Clemson, SC, (2)University of Tokyo, Tokyo, Japan

556. Structure related Hemostatic Property of Human Hair Extracted Keratins at Different Temperature, L. Huang, Y. Wei*; National Taipei University of Technology, Taipei, Taiwan

557. Designing an Antimicrobial Knitted Spacer Fabric with Chitosan for Vacuum Assisted Wound Closure, D. Zha*(1), P. Nakod(1), T. He(2), A. El-Shafei(1), A. Brown(3); (1)College of Textile, North Carolina State University, Raleigh, NC, (2)IINVISTA, Seaford, DE, (3)Joint Department of Biomedical Engineering, North Carolina State University & UNC - Chapel H

558. Development and Evaluation of Novel Smart Dressing Containing a Biosensor to Monitor Infected Wounds, J Lee*, T Yeo, Y Ko, O Kwon; Kumoh National Institute of Technology, Gumi, Republic of Korea

559. Chitosan-based injectable and self-healing hydrogels with high strength for hemostasis, W Huang*, L Chen; University of Alberta, Edmonton, AB

560. Comparing Polyhexanide and Gentamicin Release from Melt-spun Poly-l-lactide, Poly-ε-caprolactone, and Cellulose acetate butyrate Fibers as Potential Wound Healing Scaffolds, E Gianino*, J Gilmore; Clemson, Clemson, SC

561. The Evaluation of the Duck's Feet Collagen Sponge for Hemostatic Applications, O Lee*, Y Seo, C Park; Hallym University, Chuncheon, Republic of Korea

Biomaterial Technologies for Precision Medicine

562. Ultrasound Stimulation Mediates Microgel Deformation to Tune Drug Release Kinetics, S. Nandi*(1), A. Joshi(2), M. Muller(2), A. Brown(1); (1)North Carolina State University/The University of North Carolina at Chapel Hill, Raleigh, NC, (2)North Carolina State University, Raleigh, NC

563. Polymer Scaffolds Protect Mice Against Diet Induced Obesity and Glucose Intolerance, M Hendley*, P Annamalai, M Gower; University of South Carolina, Columbia, SC

564. Engineering Fibrin Nanoparticles to Enhance Wound Healing, I Muhamed*, E Sproul, F Ligler, A Brown; North Carolina State University and University of North Carolina at Chapel-Hill, Raleigh, NC

565. Biomechanical Evaluation of Injectable Biomaterials for Vocal Fold Augmentation, J Pearson*(1), S Montelongo(1), T Guda(1), G Dion(2); (1)University of Texas at San Antonio, San Antonio, TX, (2)San Antonio Military Medical Center, Ft. Sam Houston, TX

566. Testing Wicking Fiber Capability: Developing a Microscope System to Observe Cell Movement in a Wicking Fiber, L Estes, Q Jones, R Marti, T Burg, K Burg*; University of Georgia, Athens, GA

567. Quantitative Prediction of Molecular Properties in a Nanopore Sensor, S Bearden*(1), T Abramyan(2), D Gil(3), J Johnson(1), D Mai(4), V Ivanov(5), V Reukov(1), G Zhang(6); (1)Clemson University, Clemson, SC, (2)University of North Carolina, Chapel Hill, NC, (3)Harvard Medical School, Boston, MA, (4)University of California,

568. Subcutaneous Nanodisc Vaccination with Dual-adjuvants for Cancer Immunotherapy, X Sun*,R Kuai,A Schwendeman,J Moon; University of Michigan, Ann Arbor, MI;University of Michigan, Ann arnor, MI

569. Covalent Functionalization of Poly(Glycerol Sebacate), B Nicholson*, J Harris, S Lu, P Gabriele, C Smoot; The Secant Group, LLC, Telford, PA

570. Surfen, a Small Molecule Glycosaminoglycan Antagonist, Attenuates Glioma Stem Cell Infiltration in a Rodent Model of Glioma, M Logun*, G Simchick, Q Zhao, L Karumbaiah; University of Georgia, Athens, GA

Biomaterial-Mediated Control of Immunity for Regenerative Medicine

571. Slower degradation of Poly (DL-lactide) particles provides better amelioration of experimental autoimmune encephalomyelitis, E Saito*, R Kuo, K Kramer, N Gohel, B Cheung, N Kaushal, L Shea; University of Michigan, Ann Arbor, MI

572. Poly(ethylene glycol) hydrogels functionalized with RGD adhesive ligands modify myeloid cell motility, but not phenotype, C Olingy, M Ogle*, J García, A García, E Botchwey; Georgia Institute of Technology, Atlanta, GA

573. Hydrogel Delivery of IL-10 Modulates Myeloid Cell Recruitment and Induces the Differentiation of Tolerogenic Cell Phenotypes, M. Sok*(1), C. Olingy(2), K. Srithar(1), A. Garcia(1), E. Botchwey(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)La Jolla Institute of Allergy and Immunology, La Jolla, CA

574. Expansion of T Cells via Poly(Dimethyl Siloxane)-based Fibrous Meshes with Tunable Rigidities, A. Dang*(1), D. Bogdanowicz(1), S. Fernandes(2), J. Brown(2), H. Lu(1), L. Kam(1); (1)Columbia University, New York, NY, (2)Dana Farber Cancer Institute, Boston, MA

575. Matrix Regenerative Nanoparticles to Improve the Tumor Microenvironment in Non-Small-Cell Lung Cancers, D. Seshadri(1), A. Ramamurthi*(2); (1)Case Western Reserve University, Cleveland, OH, (2)Cleveland Clinic, Cleveland, OH

576. WITHDRAWN

577. Engineering Immunomodulatory Adhesive Hydrogel for Inflammation Control in Diabetic Wounds, B. Saleh, H. Dhaliwal, E. Shirzaei Sani, R. Portillo-Lara, M. Amiji, N. Annabi*; Northeastern University, Boston, MA

578. Precision-engineered Porous Polyurethane Resists Foreign Body Capsule Formation and Promotes Vascularization by Modulating Macrophage Response, L Zhen*, B Ratner; University of Washington, Seattle, WA

579. An Injectable Liposome to Direct Macrophage Phenotype in Muscle Injury, C Kraynak*, L Suggs; University of Texas at Austin, Austin, TX

580. Direct Irradiation Synthesis of Nanostructured Biointerfaces to Enhance the Longevity and Osseointegration of Titanium Implant Materials in Hard Tissue, A Barnwell*, A Civantos, A Shetty, J Allain; University of Illinois Urbana-Champaign, Urbana, IL

581. Delayed Delivery of Simvastatin Increases In Vitro Osteogenesis and Modulates Inflammatory Macrophages, J. Alhamdi*(1), M. Hurley(2), K. Spiller(3), L. Kuhn(2); (1)University of Connecticut, Farmington, CT, (2)University of Conneticut health center, Farmington, CT, (3)Drexel University, Philadelphia, PA

582. Two-compartment, Magnetically Active Biomaterial System for Sequential Recruitment and Instruction of Cells, A Tolouei, T Emi, S Madani, N Dulger, S Kennedy*; University of Rhode Island, Kingston, RI

583. Assessing the Immunomodulatory Properties of a Polyurethane Hydrogel Microsphere Protein Delivery System, E. Tawagi*, S. Zhao, H. Cheng, P. Santerre; University of Toronto, Toronto, ON

584. Heparin/Poly-L-lysine-coated 3D-printed PLGA scaffolds as drug carriers for  local immune modulation in bone regeneration, T Nguyen*(1), H Kim(2), A Dang(1), L Kam(1), J Lee(1); (1)Columbia University, New York, NY, (2)National Institute of Health, Bethesda, MD

585. Designer Immune Organoids with T Cell Signals for Selective Enrichment of Antigen-specific B cells, A. Purwada(1), S. Shah*(1), W. Beguelin(2), A. August(1), A. Melnick(2), A. Singh(1); (1)Cornell University, Ithaca, NY, (2)Weill Cornell Medical College, New York, NY

586. Shape Specific Cerium Oxide Nanoparticles Modulate Macrophage Phenotype, V RAKSHE*(1), S SANT(2); (1)University of Pittsburgh School of Pharmacy, Pittsburgh, PA, (2)University of Pittsburgh, Pittsburgh, PA

587. Iron Oxide Nanoparticles Inhibit Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing M1 Macrophage Polarization, L. Liu, R. Jin*, J. Duan, L. Yang, H. Ai; (1)National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, (2)National Engineering Research Center for Biomaterials, Sichuan University   West China Hospital, Sichuan University,

588. Engineered Hydrogels to Manipulate Inflammatory Th17 cells in a Murine Model of Hypersensitivity Pneumonitis, J Elmore*, C Carter, A Bennett, A Redko, M Mosquera, A August, A Singh; Cornell University, Ithaca, NY

Biomaterials and Medical Products Commercialization SIG

589. Green vs. Traditional Electrospinning: Matching Fiber Properties and Cell Response, C. Mosher*, Z. Gong, H. Lu; Columbia University, New York, NY

590. Fabrication of Antibacterial Foam Dressing Including Silver-Carbon Composite for Effective Wound Healing, Y Ko*(1), T Yeo(1), J Lee(1), W Park(2), D Cho(1), O Kwon(1); (1)Kumoh National Institute of Technology, Gumi, Republic of Korea; (2)Chungnam National University, Daejeon, Republic of Korea

Biomaterials and Scaffolds for Interfacial Tissue Engineering

591. Designing a Chitosan-Based Thermosensible Hydrogel with high Bioadhesive and Mechanical Properties, and Compatible with Cell Therapy, C Guyot*(1), S Samaei(1), M Cerruti(2), S Lerouge(3); (1)Centre de Recherche du CHUM, Montréal, QC, (2)McGill University, Montréal, QC, (3)École de Technologie Supérieure, Montréal, QC

592. Umbilical Cord Blood Derived Fibrin Net and Platelet-Rich-Plasma Have Potency in Osteogenic Regenerative Medicine, K Baba*, Y Yamazaki, Y Sone, Y Sugimoto, K Moriyama, T Sugimoto, K Kumazawa, A Takeda; School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan

593. Gradient Immobilization of Platelet-derived Growth Factor on a Nanofiber Surface by Controlled Dopamine Polymerization for Tendon-Bone Tissue Engineering, S. Madhurakkat Perikamana*, J. Lee, S. Lee, H. Shin; Hanyang University, Seoul, Republic of Korea

594. Effects of Scaffold Geometry on Development of S. aureus Tolerance to Antibiotic Treatment, T Spoonmore*(1), J Cassat(2), J Wenke(3), S Guelcher(1); (1)Vanderbilt University, Nashville, TN, (2)Vanderbilt University Medical Center, Nashville, TN, (3)US Army Institute of Surgical Research, Ft Sam Houston, TX

595. Mineral-Based Approach for Modulation of Stem Cell Fate, A. Brokesh*, L. Cross, J. Carrow, B. Vonasek, A. Gaharwar; (1)Texas A&M University, College Station, TX, (2)Texas A&M Engineering, College Station, TX

596. BMP-2 Modified Nano-Fibers for Soft Graft-Bone Integration During Ligament Reconstruction, D Gadalla*, A Goldstein; Virginia Tech, Blacksburg, VA

597. Abaca cellulose-based fibers for MSCs culture, R de Guzman*(1), H de Guzman(2); (1)Hofstra University, Hempstead, NY, (2)New York University, Tuxedo, NY

598. Surface Modification of Biodegradable Porous Magnesium-Based Bone Implant, V. Posada*(1), A. Shetty(2), A. Civantos(2), P. Fernandez-Morales(3), J. Ramírez(1), J. Allain(2); (1)Universidad Nacional de Colombia, Medellin, Colombia, (2)University of Illinois at Urbana-Champaign, Urbana Champaign, IL, (3)Universidad Pontificia Boli

599. Surface Nanomodification of Porous Titanium Scaffolds to Improve in vitro Bone Osseointegration, A. Civantos*(1), A. Shetty(1), S. Arias(1), R. Pino(2), C. Dominguez(3), Y. Torres(3), J. Rodriguez(3), J. Allain(4); (1)University of Illinois, Urbana-Champaign, IL, (2)University of Antioquia, Medellin, Colombia, (3)University of Seville, Sevilla, Spain

600. Effects of Copper on Physical, Mechanical, and Biological Properties of Brushite Cement, H. Cummings*(1), W. Han(2), K. Elkwae(1), S. Vahabzadeh(1), S. Elsawa(2); (1)Northern Illinois University, Dekalb, IL, (2)University of New Hampshire, Durham, NH

601. Development of N-Oxalylglycine-Conjugated Hyaluronic Acid for Therapeutic Angiogenesis, A DeMaria*, K Webb, J Lee; Clemson University, Clemson, SC

602. Bone Tissue Engineering Scaffolds based on Polyampholyte Hydrogels with Conjugated SIBLING Proteins, M Bernards*(1),C Qin(2),S Haag(1); (1)University of Idaho, Moscow, ID;(2)Texas A&M University, Dallas, TX

603. Core-shell Nanofibers Modified by Cold Atmospheric Plasma (CAP) for Tissue Engineering Applications, Y Zhou*(1),M Wang(1),T Webster(1),M Keidar(2); (1)Northeastern University, Boston, MA;(2)George Washington University, Washington, DC

604. Fabrication of Cell Laden Fiber/Hydrogel Construct for Ligament Tissue Engineering, Y Jeong*,C Park; Kyungpook National University, Daegu, Republic of Korea

Biomaterials Education SIG

605. Building Critical Skills in Biomaterials Applications and Medical Device Development:  An Established Curriculum Linking Engineering, Commercialization and Clinical Adoption, F. Schoen*(1), J. Reilly(2); (1)Brigham and Women's Hospital, Harvard Medical School, Boston, MA, (2)Harvard Medical School, Boston, MA

606. Effect of Shot Peening on Stress Corrosion Behavior of Biodegradable Magnesium WE43, T. Patil*, M. Sealy, F. Bobaru; University of Nebraska Lincoln, Lincoln, NE

Biomaterials for Cardiovascular Regeneration

607. Predicting Rupture Potential of Abdominal Aortic Aneurysms with Gold Nanoparticles Targeting to Degraded Elastin, X. Wang*(1), S. Karamched(1), V. Parasaram(1), B. Lane(2), S. Lessner(2), J. Eberth(2), N. Vyavahare(1); (1)Clemson University, Clemson, SC, (2)University of South Carolina School of Medicine, Columbia, SC

608. Bioprinted Patch with Cardiac Extracellular Matrix and Human Cardiac Progenitor Cells for Heart Regeneration, D Bejleri*, M Davis; Georgia Institute of Technology and Emory University, Atlanta, GA

609. Polyethylene Glycol-conjugated Peptide promotes Therapeutic Angiogenesis in Diabetic Hindlimb Ischemia, H Park*(1), S Kim(2), Y Son(2), H Hong(2), S Cho(1); (1)Yonsei University, Seoul, Republic of Korea, (2)Kyung Hee University, Yong In, Republic of Korea

610. Delivery of Nitric Oxide and Antioxidant via Nanoparticles for the Treatment of Peripheral Artery Disease, D Le*(1), A Kuriakose(1), T Nguyen(1), D Nguyen(1), K Nguyen(1), S Acharya(2); (1)University of Texas at Arlington, Arlington, TX, (2)University of North Texas Health Science Center, Fort Worth, TX

611. Methacrylated PGS-Gelatin 3D Honeycomb Patterned Scaffolds for Cardiomyocyte Delivery and Maturation, V. Morris*, M. Huang, S. Bae, A. Andukuri, Y. Yoon; Emory University School of Medicine, Atlanta, GA

612. Nanofiber-hydrogel Composite Material for the Treatment of Acute Myocardial Infarction, C Chang*(1), X Li(1), H Mao(1), T Fukunishi(2); (1)Johns Hopkins University, Baltimore, MD, (2)Johns Hopkins School of Medicine, Baltimore, MD

613. C-Jun N-terminal Kinase Gene Silencing to Stimulate Elastic Matrix Regenerative Repair in a Proteolytic Disorders, D. Ortiz-Serrano*, A. Camardo; Cleveland Clinic, Cleveland, OH

614. Mesenchymal Stem Cell Response on Acellular Porcine Pericardium in a Subcutaneous Rat Model, J. Go, R. Khorramirouz*, C. Noble, S. Jana, D. Morse, E. Maxson, A. Lerman, M. Young; Mayo Clinic, Rochester, MN

615. Biocompatible Nanofiber Yarns for Cardiac Muscle Tissue regeneration, A Sunil Richard*, J Sarvepalli, R Verma; Indian Institute Of Technology Madras, Chennai, India

616. Engineering Conductive Fibrous Patches for Cardiac Tissue Regeneration, B. Walker, C. Hsiang Yu, R. Portillo-Lara, E. Shirzaei Sani, W. Kimball, N. Annabi*; Northeastern University, Boston, MA

617. Engineering Blood Vessels through Dynamic Culture of Biomimetic Scaffolds, A. Goins*, J. Allen; University of Florida, Gainesville, FL

618. Nano-spheres and -rods for Targeting Dysfunctional Endothelial Glycocalyx, M Cheng*, P Prabakaran, R Kumar, S Sridhar, E Ebong; Northeastern University, Boston, MA

619. Tissue Engineered Living Aortic Heart Valve Roots: In vitro Characterization and Revitalization, M Casco*, D Simionescu; Clemson University, Clemson, SC

620. Designing a Bilayer Small Diameter Vascular Prosthesis from Collagen and Tropoelastin Yarns in a Knitted and Electrospun Tissue Engineered Scaffold, F. Zhang*(1), Y. Xie(1), O. Akku(2), M. King(1); (1)North Carolina State University, Raleigh, NC, (2)Case Western Reserve University, Cleveland, OH

Biomaterials for Regenerative Engineering Applications

621. Fabrication of Methylmethacrylamide and 2-hydroxyethyl methacrylate  Hydrogel Injectable Filler for Soft Tissue Engineering, C Heo(1), K Lee(1), J Shim(2), S Kim*(1); (1)Seoul National University, Seoul, Republic of Korea, (2)Seoul National University Bundang Hospital, Seongnam, Republic of Korea

622. Pathology-targeted Cell Delivery via Injectable Micro-scaffold Capsule Mediated by Endogenous TGase, C. Qi*; Tsinghua University, Beijing, China

623. Self-assembled Nanocomposite Hydrogels Driven by Bisphosphonate-Mg2+ Coordination Regulate the Differentiation of Encapsulated Stem Cells and Promote in-situ Bone Regeneration, K Zhang*, S Lin, Q Feng, G Li, L Bian; The Chinese University of Hong Kong, Shatin, Hong Kong

624. Novel Tannic Acid Implant Material for Tissue Regeneration and Anti-Cancer Activity following Breast Cancer Treatment, A. Baldwin*, K. Williams, B. Booth; Clemson University, Clemson, SC

625. Cell Sheet on Electrospun Fibrous Mesh for Tissue Regeneration, L. Jin, Z. Ren, Q. Cai, X. Yang*; Beijing University of Chemical Technology, Beijing, China

626. An Ice-Templated Chitosan-based Ureteral Stent, P. Divakar*, K. Yin, U. Wegst; Dartmouth College, Hanover, NH

627. Growth Factor-free Bioactive Nanocomposite Promotes Bone Regeneration in vivo, A Patel(1), S Zaky(1), E Beniash(1), C Sfeir(1), H Li(1), S Velankar(1), Y Wang(2), D Stolz(1), S Sant*(1); (1)University of Pittsburgh, Pittsburgh, PA, (2)Cornell University, Ithaca, NY

628. Design, Structure, Material Strength and Release Profile of Dissolvable Microneedle Patches, M Mofidfar*, M Prausnitz; Georgia Institute of Technology, Atlanta, GA

629. Biomimetic Mesh Scaffold Containing Human Lung Fibroblast-Derived Extracellular Matrix and Inorganic Minerals for Bone Regeneration, J. Lee*, K. Park; Korea Institute of Science and Technology, Seoul, Republic of Korea

630. Nanosilver and Apatite Mounted Biodegradable Microspheres for Bone Regeneration, P. Wei*, Q. Cai, X. Yang; Beijing University of Chemical Technology, Beijing, China

631. Bio-inspired Cell Culture Platforms for Improved Epidermal Regeneration in vitro, D. Davis-Hall*(1), V. Nguyen(1), T. D'ovidio(2), E. Tsai(3), G. Bilousova(2), C. Magin(2); (1)University of Colorado Denver, Aurora, CO, (2)University of Colorado Anschutz Medical Campus, Aurora, CO, (3)Metropolitan State University of Denver, Denver, CO

632. Characterization and 3D Printing of Gelatin Methacrylate Resin, W Surbey*, N Chartrain, C Williams, A Whittington; Virginia Tech, Blacksburg, VA

633. Tailorable PEGDMA Scaffold to Improve Cell-Based Regenerative Therapies, H. Barnett*, A. Whitehead, J. Newman, M. Caldorera-Moore; Louisiana Tech University, Ruston, LA

634. Targeted Delivery of Nanoparticles to Emphysematous Lungs: Systemic versus Local Therapy, V Parasaram*, X Wang, N Vyavahare; Clemson University, Clemson, SC

635. Novel 3D Hybrid Nanofiber Aerogels for Cranial Bone Regeneration, J Xie*, S Kumar, H Wang; University of Nebraska Medical Center, Omaha, NE

636. Preventing Hypoxia-induced Beta Cell Death and Dysfunction via Oxygen-generating Microbeads, J. Liang*, M. Coronel, M. Dang, C. Stabler; University of Florida, Gainesville, FL

637. Precise Control Delivery of Magnesium Ions thru Sponge-Like Monodispersed PLGA/nano-MgO-Alginate Core-Shell Microsphere Device to Enable in-situ Bone Regeneration, z. Lin*(1), J. Wu(2), Y. Zhao(3), K. Cheung(1), F. Leung(1), P. Chu(4), K. Yeung(1); (1)The University of Hong Kong, Hong Kong, China, (2)the University of Hong Kong Shenzhen Hospital, Shenzhen, China, (3)Shenzhen Institutes of Advanced Technology, Shenzh

638. An Innovative Laboratory Procedure to Expand Chondrocytes with Reduced Dedifferentiation chon, Y Mao*, T Hoffman, A Wu, J Kohn; New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ

639. Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stem Cells on Tailorable Hydrogel Scaffolds, R. Eddy*, I. Pursell, H. Barnett, A. Whitehead, M. Caldorera-Moore, J. Newman; Louisiana Tech University, Ruston, LA

640. Investigation of the Cell-loading and Differentiation Potential of Keratin-based Microparticles, M. Thompson*, M. Van Dyke; Virginia Tech, Blacksburg, VA

641. Induce BMSCs Differentiate into Neural Cells with Synergistic Multiple Factors, W. Jing*, Q. Cai, X. Yang; Beijing University of Chemical Technology, Beijing, China

642. A Pro-Angiogenic Peptide-Tethering Platform Using Biotinylated Tyrosine-Derived Polymeric Fiber Mats, A. Pastino*, M. Guvendiren, R. Goyal, O. Freeman, Y. Mao, K. Dube, J. Kohn; Rutgers University, Piscataway, NJ

643. The Biological Effect on Physical Modified Chitosan Nanofiber Scaffolds, B Gu*, S Park, C Kim; Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea

644. Integrating Experiments and MD Simulations to Determine the Degradation of poly-4-hydroxybutyrate for Surgical Suture Applications, R Vaid*, M Pasquinelli, M King; North Carolina State University, Raleigh, NC

645. Ultrasound-Derived Mechanical Loading with Cell Therapy for Bone Repair, F. Assanah*(1), J. Veronick(1), P. Maye(2), Y. Khan(1); (1)University of Connecticut, Farmington, CT, (2)University of Connecticut Health Center, Farmington, CT

646. Vascular Endothelial Growth Factor Delivery from Functionalized Bone Allografts to Enhance Bone Repair, K. Grassie*, F. Assanah, Y. Assanah; University of Connecticut, Farmington, CT

647. 3D Aligned Fibrous Scaffold on a Small Diameter Vascular Format, F. Ng*, Y. Ong, H. Gustafianto, L. Tan; Nanyang Technological University, Singapore, Singapore

648. A General Method for Assembling Cells into Macroscopic Scaffold-free Tissues, L Yang*, K Lee; Rutgers, the State University of New Jersey, Edison, NJ

649. Preparation and In Vitro Characterization of an Integrated Graft System for Regenerative Engineering, M Barajaa*, L Nair, C Laurencin; University of Connecticut Health, Farmington, CT

650. Dynamic 3D Hydrogel Scaffolds for Tissue Regeneration Applications, R Hegab, H Barnett, M Caldorera-Moore*, A Heimbuck, J Newman; Louisiana Tech University, Ruston, LA

651. Raman Spectroscopic Analysis of Plant Cell Wall in Normal and Diseased Sunflower, M Roy*, B Kontz, F Mathew, A Prasad; South Dakota State University, Brookings, SD

652. Synthesis and Evaluation of Poly(octamethylene citrate β-glycerophosphate) (POC-βGP) for Bone Regeneration, Q Li*, J Guo, J Chen, J Yang; the Pennsylvania University, State College, PA

Biomaterials Platforms for Scaffold-Free Tissue Engineering

653. Effect of Polyelectrolyte Molecular Weight on Adipocyte Spheroid Maturation and Retention atop Amphiphilic Coatings, S. Fitzgerald*, J. Cobb, A. Janorkar; Univ of Mississippi Medical Center, Jackson, MS

654. ECM Protein Shrink-Wrapped Cells Demonstrate Enhanced Integration into Corneal Endothelium, R. Palchesko*, A. Feinberg; Carnegie Mellon University, Pittsburgh, PA

655. Microstructure of Gelatin Colloidal Gel Controls Endothelial Cell Organization, S. Nair*, D. Sarkar; University at Buffalo, The State University of New York, Buffalo, NY

656. Study of Cellular Self-Assembly Behaviors on Hydrocarbon Fluidic Substrates, M Maruyama*, Y Tada; Hitachi Ltd., Hitachi, Japan

657. Formation of Stem Cell Aggregates via Surface-Mediated Self-Assembly, K Barteau*, A Xie, W Murphy; University of Wisconsin Madison, Madison, WI

Biomaterial-Tissue Interaction SIG

658. Copper Doped Tricalcium Phosphate; Phase Composition and In Vitro Interaction with Osteoblast Cells, W. Han*(1), H. Cummings(2), S. Fleck(2), S. Vahabzadeh(2), S. Elsawa(1); (1)University of New Hampshire, Durham, NH, (2)Northern Illinois University, DeKalb, IL

659. Histological Changes in Swine Subcutaneous Tissue Surrounding Commercial Continuous Subcutaneous Insulin Infusion (CSII) Catheters with a PTFE Cannula, A. Khalf*; Thomas Jefferson University, Philadelphia, PA

660. "Ruffled Border" Formation on a CaP-free Substrate: a First Step towards Osteoclast-Recruiting Bone-Grafts Materials able to Re-Establish Bone Turn-Over, S Fung*, A Merolli, S Murthy, E Pashuck, Y Mao, X Wu, J Steele, D Martin, P Moghe, T Bromage, J Kohn; Rutgers, The State University of New Jersey, Piscataway, NJ; New York University College of Dentistry, New York, NY

661. Development of an easy-to-use microneedle patch for collection of dermal interstitial fluid, C Kolluru*, M Williams, M Prausnitz; Georgia Institute of Technology, Atlanta, GA

Cancer Nanotechnology

662. Microvesicles Contribute to Matrix Remodeling and Cancer Heterogeneity, S Schwager*(1), L Hapach(2), F Bordeleau(1), M Antonyak(2), R Cerione(2), C Reinhart-King(1); (1)Vanderbilt University, Nashville, TN, (2)Vanderbilt University, Cornell University, Nashville, TN

663. Natural Killer Cell Engineering for Therapeutic Targeting of Metastases in the Tumor Draining Lymph Nodes, Z Zhang*, D Liu, J Greenlee, F Yu, N Ortiz-Otero, T Cao, M King; Vanderbilt University, Nashville, TN

664. A mechanistic study of anti-HIV activity and cancer registry match investigation in laboratory drug 2- Indolinones show record linkage among them many interesting leads evaluation, R. Hajare*(1), R. Paranjape(2); (1)RD College of Pharmacy, Pune, India, (2)National AIDS Research Institute Pune, Pune, India

665. Hydrophobic Core, pH-responsive ABC Triblock Copolymers for Formulation of Stabilized siRNA Polyplexes, M Stokan*(1), M Jackson(2), S Bedingfield(2), T Werfel(2), C Duvall(2); (1)University of Kentucky, Lexington, KY, (2)Vanderbilt University, Nashville, TN

666. Development of a Histotrpisy Agent using Host-Guest Interaction., T Rehman*(1), E Vlaisavljevich(2), Y Yuksel Durmaz(1); (1)Istanbul Medipol University, Istanbul, Turkey, (2)Virginia Polytechnic Institute and State University, Blacksburg, VA

667. Influence of Gold Nanoparticle Size on Uptake into Different Ovarian Cancer Cell Lines measured by Spectral Photon-counting CT, M Moghiseh*(1), D Kumar(1), R Aamir(1), P Sykes(1), C low(1), A Butler, N Anderson; (1)University of Otago, Christchurch, New Zealand

668. Synthesis and Characterization of Lipid Nanoparticle Formulation of a Poorly Soluble, Highly Potent, Novel Synthetic Analog of Curcumin for Cancer Therapy, A. Pradhan*(1), S. Mishra(2), A. Surolia(3), R. Srivastava(1), D. Panda(1); (1)Indian Institute of Technology, Bombay, Mumbai, India, (2)University and Institute of Advanced Research, Gandhinagar, India, (3)Indian Institute of Science, Bangalore, India

669. IR820-Loaded Poly(lactic-co-glycolic acid) Nanoparticles for Photothermal Cancer Therapy, D. Valcourt, S. Peden, E. Day*; University of Delaware, Newark, DE

670. Glutathione-sensitive nanoparticles for lung cancer treatment, R Iyer*, D Padanilam, D Zhukova, C Xu, K Nguyen, Y Hong; University of Texas at Arlington, Arlington, TX

671. In vivo Assessment of Toxicity of Gold Nantheranostic Agent, N El-Baz*, K James, R Chauhan, D Malik, B Nunn, A Switala, A El-Baz, R Keynton, P Bates, T Malik, M O' Toole; University of Louisville, Louisville, KY

672. Magnetically Triggered Drug Release from Nanoparticles, E Fuller*, H Sun, B Sumerlin, C Rinaldi; University of Florida, Gainesville, FL

673. Spectral Photon-Counting CT imaging of Gold Labelled Monoclonal Antibody Drug Delivery to Raji and HER2 Positive Beast Cancer Cells – A Phantom Study, C. Lowe*, A. Raja, M. Moghiseh, J. Lewis, A. Butler, N. Anderson; University of Otago, Christchurch, New Zealand

674. Cancer-exosome-mimetic Nanovesicles for Homotypic Cell Recognition, G Abbott*, C Mao; University of Oklahoma, Norman, OK

675. Ultrasound Enhanced Release of a Model Drug from Transferrin-Coupled Liposomes, N AlSawaftah, P Kawak, G Husseini*; American University of Sharjah, Sharjah, United Arab Emirates

676. Acoustically Activated Accumulation and Release from Estrone-Targeted Liposomes in the Treatment of Breast Cancer, N Salkho, R Vitor, A Martins, M Al Sayah, G Husseini*; American University of Sharjah, Sharjah, United Arab Emirates

677. Novel Synthesis of Iron-based Metal-Organic Framework for Site-specific Doxorubicin Delivery, M Ibrahim, R Sabouni, G Husseini*; American University of Sharjah, Sharjah, United Arab Emirates

678. Ultrasound Enhanced Release of Albumin Coupled Liposomes Used for breast Cancer Treatment, G Husseini*, N Awad, V Paul, M Al-sayah; American University of Sharjah, Sharjah, United Arab Emirates

679. End-to-end Clicking of Gold Nanorods for Controlling Cellular Uptake, Y Son*, H Yoo, S Lee, W Mao, J Shin, J Lee; Kangwon National University, Chuncheon, Republic of Korea

680. Targeted Immunomodulation of CD8+ T Cells with F(ab')2-conjugated Liposomes, C Park*, J Moon; University of Michigan, Ann Arbor, Ann Arbor, MI

Cardiovascular Biomaterials SIG

681. Tissue-engineered Atherosclerosis Model in a Physiological Bioreactor, J Chen*(1), G Alexander(1), C Bae(1), P Hwang(1), C Zhang(1), Y Yoon(2), P Sethu(1), B Brott(1), J Kim(1), H Jun(1); (1)University of Alabama at Birmingham, birmingham, AL, (2)Emory University, Atlanta, GA

682. A Fluoroscopic, Mechanically Tunable, Bioresorbable Synthetic Polymer for Cardiovascular Applications, J Wright*, A Nguyen, J Wang, R Jaquiss, T Welch; University of Texas Southwestern Medical Center, Dallas, TX

683. How to Keep the Native Structure and Bioactivity of the Acellular Biological Scaffolds for Tissue Regeneration, T. Yamaoka*(1), H. Yamanaka(1), A. Mahara(1), N. Morimoto(2); (1)National Cerebral and Cardiovascular Center Research Institute, Suita, Japan, (2)Kansai Medical University, Hirakata, Japan

684. Proangiogenic Peptide Scaffolds for Myocardium Regeneration, P. Nguyen*, A. Chirayath, B. Sarkar, V. Kumar; New Jersey Institute of Technology, Newark, NJ

685. Crosslinked Poly(acrylic acid)-Erythrocruorin Nanoparticles: A Highly Stable Blood Substitute, K. Spivack*, N. Comolli, J. Elmer; Villanova University, Villanova, PA

686. The Effect of Thermal Treatment on the Local Compressive Strength of a Polydioxanone Braided Stent, F. Zhao*(1), L. Wang(1), F. Wang(1), M. King(2); (1)Key Laboratory of Textile Science and Technology of Ministry of Education, Shanghai, China, (2)North Carolina State University, Raleigh, NC

687. Schwann Cell Monolayers Naturally Enhance Cardiomyocyte Maturation, J Soucy, D Diaz, A Koppes, N Annabi, R Koppes*; Northeastern University, Boston, MA

688. Natural Polymers of Bacterial Origin for Cardiac Regeneration, P Dubey(1), E Humphrey(2), M Stevens(2), C Terracciano(2), S Harding(2), I Roy*(1); (1)University of Westminster, London, United Kingdom, (2)Imperial College London, London, United Kingdom

689. Superhemophobic Titania Nanotube Array Surfaces for Blood Contacting Medical Devices, K Popat*, K Bartlett, S Movafaghi, A Kota; Colorado State University, Fort Collins, CO

Current Approaches to Treat Cardiovascular Calcification

690. Examining Cellular Mechanics In Vascular Calcification, N Nguyen*, C Simpson; Mississippi State University, Mississippi State, MS

691. Alginate Hydrogels as an Injectable Cell Delivery System, V. Mullins*, C. Simpson; Mississippi State University, Mississippi State, MS

692. Regulating the Phenotypic Switch of Smooth Muscle Cells in Vascular Calcification Using a Protein- Based Inhibitor, K Parker*(1), K McArthur(1), J Mosier(1), A Kay(2), J Stewart(2), C Simpson(1); (1)Mississippi State University, Mississippi State, MS, (2)University of Mississippi, University, MS

693. Nanoparticle Targeting to Reverse Aortic Calcification in a Modified Mouse Model of Adenine-Induced Chronic Kidney Diease, S Karamched*, X Wang, N Vyavahare; Clemson University, Clemson, SC

694. WITHDRAWN

Dental/Craniofacial Biomaterials SIG

695. Methylcellulose Based Injectable Gel Scaffolds Incorporating BMP-9 coated Chitosan Microparticles for Bone Regeneration Applications, B Gaihre*(1), C Jayasuriya(2); (1)The University of Toledo, Toledo, OH, (2)The University of Toledo Medical Center, Toledo, OH

696. Understanding the Surface Performance of Titanium Dental Implants: A Comprehensive in-vivo and in-vitro Study, D Rodrigues(1), K Palmer(1), T Wilson(2), P Valderrama(2), F Wang(1), S Sridhar*(1); (1)The University of Texas at Dallas, Richardson, TX, (2)North Dallas Dental Health, Dallas, TX

697. Mineralized E1001(1k) Scaffolds for Bone Tissue Regeneration: The Effect of Dicalcium Phosphate Dihydrate Composition on Human Dental Pulp Stem Cells, W Chang*(1), S Saxena(1), A Fakhrzadeh(1), E Pashuck(1), W Zhang(2), P Yelick(2), J Kohn(1); (1) New Jersey Center for Biomaterials, Rutgers University, Piscataway, NJ, (2) Tufts University, School of Dental Medicine, Boston, MA

698. Incorporation of Iron to Titanium Nanotube; Processing, Characterization, and In Vitro Cellular Interaction, M Duvvuru*, S Vahabzadeh; Northern Illinois University, Dekalb, IL

699. Additive Effects of Biomolecular Supplementation in Mineralized Collagen Scaffolds for Bone Regeneration, A Tiffany*, B Harley; University of Illinois Urbana-Champaign, Champaign, IL

700. PEEK composites embedding natural silica fibers and lithium zirconium silicates, J Souza*(1), R Curtarelli(2), P Monich(2), M Fredel(2), B Henriques(2), F Silva(1); (1)University of Minho, Guimarães, Portugal, (2)UFSC, Florianópolis, Brazil

701. Osteogenic Potential of Machined, Resorbable Blast-Textured, and Laser-Etched Titanium Dental Implant Surfaces, A. Nelson*, T. Wick; University of Alabama at Birmingham, Hoover, AL

702. Effect of Hot Isostatic Pressure Treatment of Ti6Al4V Laser Sintered Constructs on Osteogenic Differentiation of Mesenchymal Stem Cells Varies with 3D Geometry, M Berger*, T Jacobs, B Boyan, Z Schwartz; Virginia Commonwealth University, Richmond, VA

703. Porcine Collagen Anorganic Bone Composite for Guided Bone Regeneration in a Canine Intrabony Defect Model, H Chen*,S Li; Collagen Matrix Inc., Oakland, NJ

704. Novel Resorbable Reinforced Collagen Membrane in Ridge Augmentation, M Hu*, N Lee, H Chen, S Li; Collagen Matrix, Inc., Oakland, NJ

705. A Pre-hydrated Bovine Collagen-Based Tissue Membrane for Guided Bone Regeneration: In Vitro and In Vivo Characterization Studies, S Li,N Lee*; Collagen Matrix, Oakland, NJ

706. Effects of Dynamic Loading on Orthodontic Tooth Movement, Q Li*; The University of Sydney, Sydney, Australia

707. Peptide-Modified Hydrogels to Enable Salivary Cell Co-Cultures, M Martinez(1), S Pradhan-Bhatt(2), R Witt(3), M Farach-Carson(4), D Harrington*(4); (1)Rice University, Houston, TX; (2)University of Delaware, Newark, DE; (3)Christiana Care, Newark, DE; (4)University of Texas Health Science Center at Houston, Houston, T

Development and Manufacture of Silk-Based Tissue Engineered Devices: From Basic Systems to Clinical Use

708. WITHDRAWN

709. Comparative Study of Formic Acid Fabricated Silk Materials, X. HU*; Rowan University, Glassboro, NJ

710. WITHDRAWN

711. Biomimetic Spider Silk Spinning, J Johansson, A Rising*; Karolinska Institutet, Huddinge, Sweden

712. Reinforcement Effect of Mono- and Multi-Filament 3D Silk Fabric Structures within the Hydrogel Matrix, K. Lee*, C. Ki, J. Kim, J. Kim; Seoul National University, Seoul, Republic of Korea

Drug Delivery SIG

713. Microneedle Patches for Sustained Release of Contraceptive Hormones, R. Terry*, W. Li, M. Prausnitz; Georgia Institute of Technology, Atlanta, GA

714. Nanofiber-Based Analgesic Bandages for Localized Treatment of Neuropathic Pain, M Patterson*, B Janet, M Skoff, C Tison; Luna Innovations, Charlottesville, VA

715. A Cell Membrane-Based Nano Device for Intravascular Targeting of Leukocytes and Therapeutic Delivery to Inflammation, Y Luo, F Wang*; Peking University, Bei Jing, China

716. Chemical Modification of Alginate for Targeted Drug Delivery, K Enck*(1), S Banks(2), H Yadav(2), M Welker(2), E Opara(1); (1)Wake Forest University - Virginia Tech, Winston-Salem, NC, (2)Wake Forest University, Winston-Salem, NC

717. Thiol Grafted Biodegradable Polyurethane Membrane for Sustain and Stable Drug Delivery System, E Song*, Y Seong, H Kim, S Jeong; Seoul National University, Seoul, Republic of Korea

718. Development of a Multi-functional Wrap for Bone Allograft Revitalization, T. Walker*(1), A. Kishan(2), E. Cosgriff-Hernandez(1); (1)University of Texas - Austin, Austin, TX, (2)Texas A&M University, College Station, TX

719. WITHDRAWN

720. In vitro evaluation of thermally induced chitosan gel-paste use for local antibiotic delivery, L Pace*, J Jennings; University of Memphis, Marion, AR

721. Highly Efficient Non-viral VEGF Gene Delivery to Human Mesenchymal Stem Cells by Lipid Based Nanoparticles, M. Zhai*, C. Mao; University of Oklahoma, Norman, OK

722. Ultrasound- and Protein-Receptor-Targeting in Cancer Treatment, R Turki, R Vitor, A Martins, M Al-sayah, G Husseini*; American University of Sharjah, Sharjah, United Arab Emirates

723. Development of the pH-Induced Secondary Structure Conversion Mixed Micelles in Anticancer Therapy, F Shih*; China Medical University, Taichung, Taiwan

724. Stretchable, Anti-Bacterial Hydrogel Activated by Large Mechanical Deformation, W Ballance*(1), Y Seo(1), K Baek(1), M Chalifoux(1), D Kim(2), H Kong(1); (1)University of Illinois at Urbana-Champaign, Urbana, IL; (2)Korea Institute of Industrial Technology, Ansan-si, Republic of Korea

725. ROS-Triggered Degradable Iron-Chelating Nanogels: Safely Improving Iron Elimination in Vivo, Z Liu*, M Xiong; University of Georgia, Athens, GA

Engineered Biomaterials for Neural Applications

726. Mechanical and Architectural Characterization of Novel Peripheral Nerve Injury Repair Scaffolds, M Wall*, C Lacko, I Singh, C Rinaldi, C Schmidt; University of Florida, Gainesville, FL

727. Topical Nucleophilic Gel Prevents Pesticide Induced Excitotoxicity and Neural Dysfunction, K Thorat*, S Pandey, S Chandrashekharappa, N V, P Vemula; Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India

728. Fabrication and Characterization of Multi Interpenetrating Networks as a Potential 3D Model for the in vitro Study of Human Astrocytes, R. Van Drunen*, E. Tsai, A. Jimenez-Vergara, D. Munoz-Pinto; Trinity University, San Antonio, TX

729. Nanoparticle Crosslinkers: Increasing the Efficacy of Surface Modification for Neural Implants, K. Woeppel*, X. Cui; University of Pittsburgh, Pittsburgh, PA

730. Reducing Microelectrode Shaft Size and Including a Soft, Permeable Base Coating Improves UEA Biocompatibility, B Velagapudi*, M Polei, P Tresco; University of Utah, Salt Lake Citu, UT

731. Hyaluronic Acid Carbon Nanotube Composite Nanofibers Increase Neurite Growth in vitro, E Steel*, J Azar, M Taleb, H Sundararaghavan; Wayne State University, Detroit, MI

732. A Modular Approach to Construct Multi-Biofunctional and Electrically Conductive Surface, J Mao, Z Zhang*; Université Laval, Quebec, QC

733. Development and Biodegradability Evaluation of Poly (L-lactic acid) and Poly (ε-caprolcatone) Blends as  Self-Expanding Surgical Patches to Advance Prenatal Fetoscopic Myelomeningocele Repair, R Tatu*(1), M Oria(2), J Peiro(2), C Lin(1); (1)University of Cincinnati, Cincinnati, OH, (2)Cincinnati Children's Hospital Medical Center, Cincinnati, OH

734. Three-Dimensional Culture Systems to Link Brain Development to Behavior, A. Magarinos(1), S. Pedron*(2), B. Harley(2), D. Pfaff(1); (1)The Rockefeller University, New York, NY, (2)University of Illinois at Urbana-Champaign, Urbana, IL

735. A Comparison of the FBR of Tethered and Untethered UEAs in Rat Cortex, M Polei*, B Velagapudi, P Tresco; University of Utah, SLC, UT

736. Electrospun Collagen Scaffold for Peripheric Nerve Regeneration, C. Rivera Martinez*, J. Mendez, J. Almodovar; University of Puerto Rico, Mayguez, Puerto Rico

737. Implantable Peptide-Hydrogel Drug Delivery System for Treating Glioblastoma Multiforme, A Gregory*, A Alexander-Bryant, E Miller; Clemson University, Clemson, SC

738. Nanomaterials for Immunotherapy against Multiple Sclerosis/Experimental Autoimmune Encephalomyelitis (EAE), A Hassani Najafabadi*, R Kuai, A Schwendeman, J Moon; University of Michigan, Ann Arbor, MI

739. WITHDRAWN

740. Synthetic Aligned Nanofibers Functionalized with GYIGSR Increase the Rate of Neural Differentiation of Mouse Embryonic Stem Cells, E Silantyeva*,W Nasir,J Carpenter,O Manahan,M Becker,R Willits; The University of Akron, Akron, OH

Engineered Microenvironments to Model Disease

741. Fabrication of Vascularized 3D-Cancer Models with Dense Stroma Using Collagen Microfibers, K. Natsuko*, M. Komeda, M. Matsusaki; Graduate School of Engineering, Osaka University, Osaka, Japan

742. Protease-Degradable Polyethylene Glycol Maleimide Microgels for Studying Lymphoid Tumor Growth and Survival, R. Stephenson*, K. Lai, A. Singh; Cornell University, Ithaca, NY

743. Collagen Amount Modulates Cardiac Function: iPS-derived Myocardial Fibrosis Models by Sedimentary Culture using Collagen Microfibers, K. Nishi*(1), M. Komeda(1), J. Lee(2), S. Miyagawa(2), Y. Sawa(2), M. Matsusaki(1); (1)Graduate School of Engineering, Osaka University, Osaka, Japan, (2)Graduate School of Medicine, Osaka University, Osaka, Japan

744. Reconstituting Microvascularized Muscle Satellite Cell Niche on a Chip, Y Lee*, S Ahn, J Yom, E Shin, J Choi, Y Jang, Y Kim; Georgia Institute of Technology, Atlanta, GA

745. Processing of Chitosan-Hyaluronic Acid Scaffolds to Produce an Optimized Breast Cancer Tumor Microenvironment, Z. Wang*, K. Xu, I. Arias, M. Le, A. Khaled, S. Florczyk; University of Central Florida, Orlando, FL

746. Influence of Biomaterial Scaffold Properties on Breast Cancer Cell Morphology and Proliferation, M Le*, Z Wang, B Ding, K Ellett, S Florczyk; University of Central Florida, Orlando, FL

747. Influence of Material Selection on Tumor-Macrophage Interactions in a Tissue Engineered Breast Cancer Model, S. Holt*, D. Alge; Texas A&M University, College Station, TX

748. Characterization of Laminin and Fibronectin-Driven Matrix Remodeling Kinetics in Liver Models, A. Mazzocchi*, R. Huntwork, S. Soker, A. Skardal; Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

749. Engineered Matrices for Studying the Effects of Tissue Stiffness on Breast Cancer Metastasis, J. Al-Saleh*, C. Gomillion; University of Georgia, Athens, GA

750. 3D Multiple Cell Spheroids in Silica Coated Fungi Network Scaffolds, X Qu*, C Mao; University of Oklahoma, Norman, OK

751. Redirection of Human HER2-positive Breast Cancer Cells, A Frank-Kamenetskii*, B Booth; Clemson University, Clemson, SC

752. Long-term Ex-vivo Survivability of Bone Tissue for Tissue Experimentation Platform, A Chakraborty*, A Prasad; South Dakota State University, Brookings, SD

753. High-throughput miniaturized fibrotic micro-niches for anti-fibrotic drug screening targeting collagen fiber-mediated mechanotransduction, Z You*, L Zhou, L Liu; School of medicine, Tsinghua University, Beijing, China

754. Micromolded Gelatin Hydrogels crosslinked with Laminin for Disease on a Chip Applications, I. Claure, E. Jones, J. Reda, R. Besser, M. Ishahak, A. Agarwal*; University of Miami, Miami, FL

755. Shape-Specific Nanoceria Effectively Mitigate Oxidative Stress-Induced Calcification of Patient-Derived Valvular Interstitial Cells, Y Xue,V Sant,S Sant*; University of Pittsburgh, Pittsburgh, PA

756. Using 3D Material Cytometry (3DMaC) to Assay Cell Behavior in Microhydrogels, K Parratt*, J Jeong, P Qiu, K Roy; Georgia Institute of Technology, Atlanta, GA

757. Development of a Multi-Layer Microvascular Airway-on-a-Chip Microfluidic Device, J Mejías*, M Nelson, K Roy; Georgia Institute of Technology and Emory University, Atlanta, GA

Engineering Cells and Their Microenvironments SIG

758. Bioactive Ovarian Hydrogels Provide a Novel Biomaterial for In Vitro Follicle Maturation, M Buckenmeyer*(1), Z Xian(1), M Sukhwani(2), K Orwig(2), B Brown(1); (1)University of Pittsburgh, Pittsburgh, PA, (2)Magee Womens Research Institute, Pittsburgh, PA

759. Mesoporous Silicate Nanoparticles/3D Nanofibrous Scaffold-based  Dual-drug Delivery for Bone Tissue Engineering, H. Sun*, Q. Yao, Y. Liu; University of South Dakota, Sioux Falls, SD

760. Engineering Hydrogels to Maintain Differentiation Phenotype of Mesenchymal Stem Cell Spheroids, K Leach*, B Hung, S Ho; UC Davis, Davis, CA

761. The Delivery of Electrical Stimulation through Conductive Membrane Induces Human  Keratinocyte Proliferation and Increases the Production of Keratins 5 and 14, Z Zhang*, H Park, Y Douville, M Rouabhia; Université Laval, Quebec, QC

762. Cell Traction Force Generated by Macrophages is Affected by Polarization Status and Polyacrylamide Gel Stiffness, P. Sharma*(1), E. Harmon(1), J. Lee(2), K. Egland(3), D. Engebretson(1), E. Gnimpieba(1); (1)University of South Dakota, Sioux Falls, SD, (2)University of Connecticut, Storrs, CT, (3)Sanford Health, Sioux Falls, SD

763. Toward development of the CellWell - a novel micropatterned semi-3D cell culture scaffold., T Ryther, R Saraswat, Z Zhu, S Wood*; South Dakota School of Mines & Technology, Rapid City, SD

764. Optimization of Silk Substrate and Fibronectin Coating for Salivary Niche Regeneration, J Pearson*(1), H Wang(2), T Guda(1), D Dean(2), X Chen(2), J Ong(1), C Yeh(1); (1)University of Texas at San Antonio, San Antonio, TX, (2)University of Texas Health San Antonio, San Antonio, TX

Enzyme-Assisted Biomaterials Fabrication and Modification for Biological Applications

765. In-Gel Fluorescent Peptide Zymography for the Analysis of Cell Secreted Proteases, A. Deshmukh*, J. Weist, J. Leight; Ohio State University, Columbus, OH

766. Tailorable Regenerating Hyaluronan Polymer Brushes: A Novel Class of Biointerfaces Generated By Hyaluronan Synthase, J Curtis*(1), J Faubel(1), W Wei(1), H Selvakumar(1), N Greenwald(1), J Washburn(2), P Weigel(2); (1)Georgia Institute of Technology, Atlanta, GA, (2)The University of Oklahoma Health Sciences Center, Oklahoma City, OK

767. Examination of Exosome purification method derived from culture supernatant of the mesenchymal cells from human ilium bone(hBMCs) which we chose, and its bone differentiation inducibility, Y Sugimoto*(1), Y Yamazaki(1), K Moriyama(1), K Baba(1), Y Sone(1), T Sugimoto(1), K Kumazawa(2), A Takeda(1); (1)Kitasato Univercity,School of Medicine, Sagamihara-city,Kanagawa, Japan, (2)Kitasato University Hospital Emergency and Disaster medical cente

Fabrication and 3D Printing of Tissue Engineering Scaffolds

768. Optimizing 3D printability in NICE bioinks through compositional and rheological analysis, L Miller, D Chimene*, A Gaharwar; Texas A&M, College station, TX

769. Three-dimensional Biodegradable Scaffolds: A Novel Approach for Tissue-Engineered Reconstruction of  Complex Maxillary Defects, J Shim*(1), H Han(2), J Lee(1), W Yun(1), C Baek(3), J Rhie(4), D Cho(5); (1)Korea Polytechnic University, Siheung-Si, Republic of Korea, (2)University of Ulsan College of Medicine, Seoul, Republic of Korea, (3)Sungkyunkwan University School of Medicine,

770. Prediction of effects of pore architecture on cell differentiation in tissue engineering scaffolds: a finite element study, B Zhang*(1), J Yang(1), J Shepherd(2), S Best(2), J Huang(1); (1)University College London, London, United Kingdom, (2)University of Cambridge, Cambridge, United Kingdom

771. Direct 3D-Printing of Thiol-ene Crosslinked HA Hydrogels with Tunable Mechanics for Tissue Repair, J. Galarraga*(1), L. Ouyang(2), C. Highley(1), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, (2)Imperial College London, London, United Kingdom

772. Assessment of Integration Between 3D Printed Stiff Hydrogels via Stereolithography and Infilled Soft Hydrogels, A Muralidharan*, R McLeod, S Bryant; University of Colorado Boulder, Boulder, CO

773. Full Factorial Design of Hierarchical 3D Scaffolds for Bone Tissue Engineering, A. Yousefi, J. Liu, S. Koo*, M. Duley, J. Zhang, P. James; Miami University, Oxford, OH

774. Phage-selected osteogenesis-inducing peptides, K. Sunderland*; University of Oklahoma, Norman, OK

775. 3D Printed Scaffolds Based on Calcium Phosphate and Hydroxypropyl Methylcellulose Ink for Bone Tissue Regeneration, F Guastaldi*(1), J Rodriguez-Chanfrau(1), T Pelizaro(1), M Silva(2), E Pizoni(1), J Carvalho(2), A Guastaldi(1); (1)São Paulo State University (Unesp), Araraquara, Brazil, (2)University of São Paulo (USP), São Carlos, Brazil

776. Cell-laden Hydrogel Microspheres Using 3D Printed Microfluidics, R Ramos*, S Suvarnapathaki, S McLoughlin, S Sawyer, P Soman; Syracuse University, Syracuse, NY

777. Yield Stress as a Critical Material Attribute in Extrusion Bioprinting, T Jiang*, J Kinsella; McGill University, Montreal, QC

778. Proliferation of HDFs on Gelatin Based Three-Dimensional Scaffolds by 3D Bioprinting, D Choi*(1), S Park(1), B Gu(1), S Chung(2), C Kim(1); (1)Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea, (2)Korea University, Seoul, Republic of Korea

779. WITHDRAWN

780. Effective Bone Tissue Regeneration Using Silk Fibroin Nanofiber/PGA Hybrid Scaffolds Fabricated by Electrospinning and 3D Printing Techniques, T Yeo*, O Kwon, Y Ko, J Lee; Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Republic of Korea

Glycomaterials

781. Composite Glycopeptide Nanofiber-Poly(Ethylene Glycol) Hydrogels to Probe Extracellular Lectin-Glycan Interactions, A Restuccia, I Baek, M Molinaro, G Hudalla*; University of Florida, Gainesville, FL

782. Chondroitin Sulfate Glycosaminoglycan "Click" Hydrogel for Neural Stem Cell Maintenance and Differentiation, M. Sun*, P. Chopra, G. Boons, L. Karumbaiah; University of Georgia, Athens, GA

783. Biomimetic Proteoglycans Enhance Type I Collagen Fibrillogenesis Mediated by Chondroitin Sulfate ‘Bristles’, C Moorehead, K Prudnikova, M Marcolongo*; Drexel University, Philadelphia, PA

784. Engineering Sugar Polymers as Highly pH-responsive Nanoscopic Assemblies, W. Du*, S. Maiti; Central Michigan University, Mount Pleasant, MI

785. Development of Cell Surface Mucin Mimetic Glycopolymers, D. Honigfort*, M. Zhang, K. Godula; University of California San Diego, La Jolla, CA

786. Comparison of MRSA biofilm inhibitory properties of commercially available veterinary wound sprays and hydrogels, R. Awais*, B. Barr, J. Jennings; University of Memphis, Memphis, TN

787. Characterization of Poly-Amido-Saccharide Secondary Structure by Molecular Dynamics Simulations, A Balijepalli*, S Chin, Q Lu, C McKnight, J Straub, M Grinstaff; Boston University, Boston, MA

Harnessing Matrix Biology to Control Cell Fate

788. The Impact of Free Protein Extracted From BM-HPME® on Bone Marrow Cell proliferation and Differentiation, S. Miar*(1), S. Griffey(2), T. Guda(1); (1)University of Texas at San Antonio, San Antonio, TX, (2)StemBioSys, San Antonio, TX

789. Mapping 3D Mechanical Strains during Tissue Formation with a Novel Fibronectin-based Nanomechanical Biosensor, D Shiwarski*, A Tsamis, Q Jallerat, J Tashman, M Blundon, J Szymanksi, B McCartney, A Feinberg; Carnegie Mellon University, Pittsburgh, PA

790. WITHDRAWN

791. Matrix Diameter Controls Migration Speed Through Focal Adhesion Molecular Arrangement, D Bowers*, J Brown; The Pennsylvania State University, University Park, PA

792. Cell-Generated, Out-of-Plane Normal Forces Strongly Correlate to In-Plane Shear Forces, O. Banda, R. Taitano, J. Slater*; University of Delaware, Newark, DE

793. Long Term Maintenance of Primary Mature Adipocytes in 3D Collagen Microfibers Tissues, F. Louis*, S. Kitano, S. Irie, M. Matsusaki; Graduate School of Engineering, Osaka University, Osaka, Japan

794. Elastic Bending and Stretching Contributions in the Mechanics of 3D Fibrillar Collagen-based Networks Determine Cancer Cell Phenotype, J. Sapudom, L. Kalbitzer, R. Chin, S. Martin, T. Pompe*; University of Leipzig, Leipzig, Germany

795. Evaluating Elastic Matrix Regenerative Potential of MSC-derived Smooth Muscle Cells in a 3-D Elastin-Deficient Tissue Milieu, S. Dahal*; Cleveland Clinic, Cleveland, OH

796. Assembly of PEG Microgels into Porous Cell-Instructive 3D Scaffolds via Thiol-Ene Click Chemistry, S. Xin*, D. Alge; Texas A&M University, College Station, TX

797. Photoreversible Patterning of Site-Specifically Modified Proteins within Gel Biomaterials, J Shadish, C DeForest*, G Benuska; University of Washington, Seattle, WA

798. Characterizing the Effect of Cell-Matrix Interactions on the Differentiation and Subsequent Vasculogenesis of iPSC-Derived Vascular Progenitor Cells, C Crosby*, D Shu, J Zoldan; The University of Texas at Austin, Austin, TX

799. Biophysical Analysis of the Self-Assembly and Matrix Mechanical Properties of Oligomeric Collagen, D. Sohutskay*, S. Voytik-Harbin; Purdue University, West Lafayette, IN

Immune Engineering SIG

800. Novel Pentablock Copolymer Micelle-Based Nanoadjuvants, S Senapati*(1), D Loh(2), I Schneider(1), M Wannemuehler(1), B Narasimhan(1), S Mallapragada(1); (1)Iowa State University, Ames, IA, (2)Johns Hopkins University, Baltimore, MD

801. Enzyme Retention via Galectin-3 for In Vivo Administration of Therapeutics, S. Freeman*, E. Bracho-Sanchez, S. Farhadi, A. Restuccia, M. Fettis, G. Hudalla, B. Keselowsky; University of Florida, Gainesville, FL

802. Modulating Immune Responses with Optimized Galectin-1 Therapies, G Hudalla, M Fettis*; University of Florida, Gainesville, FL

803. Tumor Angiogenesis and Lymphangiogenesis Effects on Size-Regulated Profiles of Tumor-derived Molecular Dissemination to Draining Lymph Node-resident Immune Cells, N. Rohner, M. O'Melia*, A. Schudel, S. Thomas; Georgia Institute of Technology, Atlanta, GA

804. DNA Netosis Engineered to Ensnare and Kill Tumor Cells, T Cao*; Vanderbilt University, Nashville, TN

805. The Anti-Tumor Effects of M1 Macrophage-Loaded Poly(ethylene glycol) and Gelatin-Based Hydrogels on Hepatocellular Carcinoma, J Kao*(1), A Guerra(2), O Yeung(1), X Qi(1), K Man(1); (1)The University of Hong Kong, Hong Kong, Hong Kong, (2)The University of Wisconsin, Madison, WI

806. A Melanin-Mediated Cancer Immunotherapy Patch, Y Ye*, Z Gu; University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC

807. Fc-functionalized Microparticles to Modulate the Physical Extent of Complement Activity, T Sulchek*; Georgia TEch, Atlanta, GA

808. Isolation of Antigen-Specific Plasma Cells using Janus Particles, K. Ramirez*, T. Sulchek; Georgia Institute of Technology, atlanta, GA

809. Cryogel-supported ex vivo Engineering of the Tumor Microenvironment in 3D, S Bencherif*, T Colombani, M Rezaeeyazdi; Northeastern University, Boston, MA

810. TRAIL-Conjugated Liposomes to Kill Chemoresistant Cancer Cells in the Lymph Nodes, J Greenlee*, Z Zhang, F Yu, D Liu, M King; Vanderbilt University, Nashville, TN

811. Proteome Analysis of Human Monocyte and Monocyte-Derived Macrophage Secretions Post Exposure to Biomaterials: Generation of Immuno-modulatory Molecules, S. Shrestha*(1), M. Mcfadden(2), A. Gramolini(1), P. Santerre(1); (1)University of Toronto, Toronto, ON, (2)Ted Rogers Centre for Heart Research, Toronto, ON

812. Effect of PEG-4MAL Hydrogel Encapsulation Parameters on Dendritic Cells, N. Beskid*, A. García, J. Babensee; Georgia Institute of Technology, Atlanta, GA

813. A 'Smart' Reporter System for the Study of Particulate Vomocytosis, N Pacifici*, A Bolandparvaz, R Stilhano, E Silva, J Lewis; UC Davis, Davis, CA

814. Synthetic Nanoparticle Antibodies Targeting Myeloid Derived Suppressor Cell for Cancer Treatment, K Roy(1), R Toy(2), P Pradhan(2), J Liu*(1); (1)Georgia Institute of Technology, Emory University, Atlanta, GA; (2)Georgia Institute of Technology, Atlanta, GA

Implantable Bioelectronics

815. Advancing Mesh Electronics Designs for Stable Early through Long-Term Chronic Neural Circuit Interrogation, R Viveros*, T Fu, G Hong, T Zhou, C Lieber; Harvard University, Cambridge, MA

816. Evaluation of Iridium Oxide – Silicone Composite Electrode Coatings for Neural Stimulation, X Kang*, G Schiavone, N Vachicouras, F Fallegger, S Lacour; Ecole Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland

817. Characterization and Application of Quantum Dots for Organic Light-Emitting Diodes (OLED), A Frank-Kamenetskii*, D Gil, E Brophy, G McNamara, M Newell, B Scammon, J Smiddy, A Thomas, V Reukov; Clemson University, Clemson, SC

818. Soft, Hydrogel-Based Electrodes with Conductive and Compressible Attributes for use in Neuroprosthetics, R Ghatee, A Tolouei, J Fijalkowski, W Besio, S Kennedy*; University of Rhode Island, Kingston, RI

819. Three-dimensional Mapping of ‘Neuron-Like’ Mesh Electronics/Brain Interfaces, X. Yang*, T. Zhou, G. Hong, T. Fu, T. Zwang, C. Lieber; Harvard University, Cambridge, MA

820. Microfabrication and in vitro Assessment of Tissue-Engineered Electronic Neural Interfaces (TEENI), C Kuliasha*, J Graham, S Mobini, B Spearman, E Atkinson, E Nunamaker, K Otto, C Schmidt, J Judy; University of Florida, Gainesville, FL

821. Gold Nanoparticle Wires Exhibit Greater Flexibility and Conductivity than Polymer Wires for Bioelectrodes, S Thourson*,A Finlay,C Landry,C Forest; Georgia Institute of Technology, Atlanta, GA

822. Neural Electrode with Artificial Conduit for  Chronic Signal Recording, W Jung, S Jung, O Kim, H Park, W Choi, D Son, J Kim*; Korea Institute of Science and Technology, Seongbuk-gu, Seoul, Republic of Korea

Intelligent Hydrogels for Biomedical Applications

823. Hyperbaric Oxygen-Generating Hydrogels for Tissue Regenerative Medicine, S Park*, K Park; Incheon National University, Incheon, Republic of Korea

824. Development of Size-controlled Extracellular matrix rich Spheroid Fabricating System by Re-assembling Micro-patterned Stem Cell Patches, H. Byun*, E. Kim, S. Kim, H. Shin; Hanyang University, Seoul, Republic of Korea

825. Enhanced Therapeutic Efficacy and Performance of Mesenchymal Stem Cell Loaded Injectable Gelatin Hydrogels for the Treatment of Myocardial Infarction in vivo, S Ryu*(1), Y Lee(1), E Park(2), K Chang(2), K Park(1); (1)Ajou University, Suwon, Republic of Korea, (2)The Catholic University of Korea, Seoul, Republic of Korea

826. Injectable Biodegradable Chitosan-Alginate Hydrogels for Gene Delivery, J Yan*, R Chen, H Zhang, J Bryers; University of Washington, Seattle, WA

827. Clicking Mesenchymal Stem Cells on Hydrogel Surfaces: Towards Applications in Wound Healing, A. Battigelli*, B. Almeida, A. Shukla; Brown University, Providence, RI

828. Stimulating tumor cell clusters by an environmental stimuli-responsive self-folding, J Lim*(1), H Kim(1), S Shin(1), S Ban(2), W Jung(2), J Jeong(1); (1)Soongsil university, Seoul, Republic of Korea, (2)Ulsan National Institute of Science and Technology(UNIST), Ulsan, Republic of Korea

829. Injectable Gelatin Hydrogels with Reactive Oxygen Species-Scavenging Properties for Therapeutic Delivery, P. Le*, K. Park; Ajou University, suwon, Republic of Korea

830. Evaluation of Gellan Hydrogel Microstructure and Drug Release Kinetics, S. Shukla*(1), J. Favata(2), A. Tripathi(1), S. Shahbazmohamadi(2), A. Shukla(1); (1)Brown University, Providence, RI, (2)University of Connecticut, Storrs, CT

831. Biomimetic Self-assembly of Porphyrin-conjugated Polyaspartamide for Molecular Ultrasound Imaging, Y Cho(1), S Oh(1), S Han(1), N Jung*(1), B Han(2), J Jeong(1); (1)Soongsil university, Seoul, Republic of Korea, (2)Cheil General Hospital and Women’s Healthcare Center, Seoul, Republic of Korea

832. Biodegradable, “Clickable” Poly(Glycolic Acid) Macromers for Hydrogel Functionalization, J. Guo*, Y. Kim, P. Engel, A. Mikos; Rice University, Houston, TX

833. Biodegradable Injectable Thermo-gelling Polymer Systems with Longer and Controllable Duration Time of Gel State, Y. Ohya*; Kansai University, Suita, Japan

834. Long-lasting and Bioactive Hyaluronic acid-hydroxyapatite Composite Hydrogels for Injectable Dermal Fillers, B Kim*, J Park, S Jeong, Y Fan, J Baek, J Song, T Choi, H Kim, S Kim; Department of Plastic and Reconstructive Surgery, Seoul National University, Seoul, Republic of Korea

835. Injectable Hyaluronic Acid Gel Microspheres for Dermal Filler Applications, Y Seong*, S Jeong, E Song, H Kim; Seoul National University, Seoul, Republic of Korea

836. A Tunable 3D Agarose-Well for Reconstructed Human Tissue, H Kim*(1), D Min(2), S Lee(2), J Lim(1), H Ryu(1), J Jeong(1); (1)Soongsil University, Seoul, Republic of Korea, (2)Amorepacific Corporation, Yongin-si, Republic of Korea

837. Characterization of Blue Light Crosslinked Poly(β-amino ester)s, N Kohrs*, D Puleo; University of Kentucky, Lexington, KY

838. Tuning the Toughness of an Alginate Microgel for Cell-Instructed Delivery, S Oh*, H Kim, S Cho, S Shin, J Jeong; Soongsil University, Seoul, Republic of Korea

839. Microscale 4D Programed Hydrogel Designed for Biomimetic Intestinal Platform, S Shin*(1), W Song(2), Y Kim(1), J Jeong(1); (1)Soongsil University, Seoul, Republic of Korea, (2)Seoul National University, Seoul, Republic of Korea

840. Thermoresponsive Hydrogels for 'Self-cleaning' Glucose Biosensor Membranes, P Dong*, A Means, F Clubb, L Colvin, G Coté, M Grunlan; Texas A&M University, College Station, TX

841. Tunable Poly((methacrylic acid)-co-acrylamide) Nanoparticles through Inverse Emulsion Polymerization, J Zhong*, J Clegg, E Ander, N Peppas; University of Texas at Austin, Austin, TX

842. Spatiotemporally Modifiable Cellulose Derived Hydrogels as Three Dimensional Scaffolds for Explants, W Gramlich*; University of Maine, Orono, ME

843. Thixotropic and Cytocompatible Hydrogels Formed from a Self-Assembling Bis-Urea Low Molecular Weight Gelator, L Rutgeerts, A Soultan, B Toprkahisar, R Subramani, H Ramon, P Moldenaers, W De Borggraeve, J Patterson*; KU Leuven, Leuven, Belgium

844. Electroconductive Hydrogel: Hyaluronic Acid-Based Hydrogel Decorated with Electroconductive Nanomaterials for Human Neural Stem Cell Engineering, J Shin*(1), Y Choi(1), E Choi(2), C Song(2), S Cho(1); (1)Yonsei Univ., Seoul, Republic of Korea; (2)Sungkyunkwan Univ., Suwon, Republic of Korea

Local Drug Delivery to Cardiovascular Targets

845. WITHDRAWN

846. Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA, M. Zamani*(1,2), C. Alcazar(1,3), L. Hou(1,2,3), T. Zaitseva(4), E. Yakubov(5), M. Paukshto(4), N. Huang(1,2,3); (1)Stanford Cardiovascular Institute, Stanford, CA; (2)Department of Cardiothoracic Surgery, Stanford University, Stanford, CA; (3)Veterans Af

Local Drug, Protein, and Gene Delivery from Implant Surfaces and Coatings

847. Local Delivery of 1,25-dihydroxyvitamin D3 for Endogenous Antimicrobial Peptide Induction, J Xie*, J Jiang, H Wang; University of Nebraska Medical Center, Omaha, NE

848. Nanocomposite of PLGA/TiO2 Nanotube Film for Controllable Drug Delivery, H Jia, L Kerr*; Miami University, Oxford, OH

Materials for Cardiovascular Devices, and Blood Compatibility

849. Evaluation of Dextran Polyelectrolyte Complex-coated Stent in a Porcine Coronary Restenosis Model, I Bae*, M Jeong, K Lim, D Park, J Park, J Park; Chonnam National University Hospital, Gwangju, Republic of Korea

850. Effect of a Polymer Free Tacrolimus Eluting Stent  by Titanium Dioxide Film Deposition in a Porcine Coronary Restenosis Model, D Park*, I Bae, M Jeong, K Lim, J Shim, S Lee, J Park; Chonnam National University Hospital, Gwangju, Republic of Korea

851. Reduced Platelet Adhesion and Activation on Plasma Treated TiO2 Nanotubes, M Benčina*(1), I Junkar(1), M Kulkarni(2), T Lampe(3), J Kovač(1), K Mrak Poljšak(4), S Sodin Šemrl(4), M Mozetič(1), M Valant(5), V Kralj Iglič(3), A Iglič(6); (1)Jožef Stefan Institute, Ljubljana, Slovenia; (2)Faculty of Science, Olomouc, Czech Republic

Nanomaterials SIG

852. Modulation of Schlemm’s Canal Endothelial Cell Stiffness via Latrunculin Loaded Block Copolymer Micelles, T. Stack*, A. Vahabikashi, M. Johnson, E. Scott; Northwestern University, Evanston, IL

853. WITHDRAWN

854. Bifunctional Peptides Induced Formation of Gold Nanoflowers with Variable Functionality for Combination Therapy, L Wang*, C Mao; University of Oklahoma, Norman, OK

855. Carbohydrate-modified Nanofibers as Tools to Study Galectin-3 Binding to Multivalent Glycans, A Restuccia*, S Farhadi, G Hudalla; University of Florida, Gainesville, FL

856. pH-responsive Charge Conversional Polymer based Gene Delivery Carriers for Cancer Treatment, K Ryu*(1), M Lee(2), H Kang(1), T Kim(2); (1)Catholic University of Korea, Gyeonggi-do, Republic of Korea, (2)Seoul National University, Seoul, Republic of Korea

857. Defect-rich Nanoassemblies of Two-dimensional (2D) MoS2 for Biomedical Applications, K. Singh*, J. Carrow, M. Jaiswal, A. Gaharwar; Texas A&M University, College Station, TX

858. Electrospinning Structured Nanofibers Using Particle Suspensions, R Patel*, E Ewaldz, B Brettmann; Georgia Institute of Technology, Atlanta, GA

859. Development of a Novel Gelatin Nanoparticle Delivery System, F Pierson, J Cary*, A Whittington; Virginia Polytechnic Institute and State University, Blacksburg, VA

860. Applying Characterization and Regression Modeling to Obtain Consistent Gelatin Nanoparticle Properties, A Stevenson*, D Jankus, M Tarshis, A Whittington; Virginia Tech, Blacksburg, VA

861. Thermal Stability and Antioxidant Activity of SOD Conjugated with Nanocrystalline Cerium Dioxide, B Skelton*(1), B Ward(1), M Bredikhin(1), D Gil(1), V Ivanov(2), V Reukov(1); (1)Clemson University, Clemson, SC, (2)Kurnakov Institute of General and Inorganic Chemistry, Moscow, Russian Federation

862. Zirconium-based Metal-organic frameworks mediate RNAi gene knockdown and extend small molecule release time, M Teplensky*(1), M Fantham(1), C Poudel(1), C Hockings(1), M Lu(1), P Li(2), O Farha(2), G Kaminski Schierle(1), C Kaminski(1), D Fairen-Jimenez(1); (1)University of Cambridge, Cambridge, United Kingdom; (2)Northwestern University, Evanston, IL

863. Surface charge controlled selective staining of nucleoli with carbon dots, Q Li*, A Su, Z Zhu, M Su; Northeastern University, Boston, MA

Next-Generation Biomaterials for Islet Delivery and Immune Acceptance for Diabetes

864. A Bio-inspired Hybrid Nanosack for Islet Transplantation in the Omentum, P Hwang*(1), D Lim(1), G Alexander(1), D Shah(1), J Garcia(1), A Shalev(1), W Cui(2), D Cooper(1), S Gilbert(1), H Jun(1); (1)University of Alabama at Birmingham, Birmingham, AL, (2)Medstar Georgetown Hospital, Washington DC, DC

865. Local Presentation of the Immunomodulatory Molecule PD-L1 via Synthetic Microgels for Islet Transplantation, M Coronel*(1), J Weaver(1), M Hunckler(1), E Yolcu(2), H Shirwan(2), A Garcia(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)University of Louisville, Louisville, KY

866. Thermoresponsive Antioxidant Hydrogels for Islet Transplantation, Y Zhu*, X Zhang, X Luo, G Ameer; Northwestern University, Evanston, IL

867. Re-vascularization of Pancreatic Islets with Self-assembled Endothelial Network, W. Song*, A. Chiu, M. Ma; Cornell University, Ithaca, NY

868. Local Delivery of Immunomodulatory Drugs to Improve the Outcome of Islets Transplantation in Type 1 Diabetes, D Velluto*(1), T De Toni(2), V Manzoli(1), A Tomei(1); (1)University of Miami, Miamia, FL, (2)Università degli Studi di Padova, Miami, FL

869. Vascular Regenerative Biomaterials for Cell Transplantation Device, V Coindre*, M Sefton; Institute of Biomaterials & Biomedical Engineering, Toronto, ON

870. Development of Polyurethane - Zwitterionic Acrylate Double Network Hydrogels as Membranes for Macro-Device Based Cell Encapsulation, A. Garle*, Y. Kudva, J. Tonne, Z. Resch, Y. Ikeda, D. Wigle, M. Yaszemski; Mayo Clinic, Rochester, MN

871. Multicomponent polyelectrolyte microcapsule for islet encapsulation: process, characterization, in vivo performance, D Treľová(1), L Uhelská(1), Z Kroneková(1), V Némethová(1), A Heydari(1), L Kleščíková(1), P Mazancová(1), F Rázga(1), V Raus(2), J McGarrigle(3), J Oberholzer(3), A Rokstad(1), I Lacík*(1); (1)Polymer Institute of the Slovak Academy of Sciences, Bratisla

872. Gellan Gum-Poly-L-Lysine Complexes: A New Biomaterial Platform for Cell Encapsulation, S Vieira*(1), E Garet(2), A Morais(1), R Reis(1), Á González-Fernández(2), J Oliveira(1); (1)3B’s Research Group, Guimarães, Portugal, (2)Immunology, Biomedical Research Center (CINBIO), Vigo, Pontevedra, Spain

873. Capillary Alginate Gel (Capgel) for the Delivery and Maintenance of Supportive Mesenchymal Stem Cells, M. Kwan*, A. Bosak, B. Willenberg; University of Central Florida, Orlando, FL

874. Linkage Groups within Thiol-Ene Photoclickable PEG Hydrogels Affect In Vivo Stability, M Hunckler*, J Medina, M Coronel, A García; Georgia Institute of Technology, Atlanta, GA

Ophthalmic Biomaterials SIG

875. Development of Therapeutic Hydrogels for Traumatic Optic Neuropathy, K. Swindle-Reilly*, S. Thobe, P. Jiang, A. Soltisz, N. Tram, M. Reilly; The Ohio State University, Columbus, OH

876. Degradation Assessment of Crosslinked CMHA-S Polymer Gel Using Gel Electrophoresis, D. Stirland*, C. Pompoco, B. Mann; Eyegate Pharmaceuticals, Inc., Waltham, MA

877. Sustained Release Anti-VEGF by Microparticles for Treating Wet Age-Related Macular Degeneration, P Jiang*, M Ohr, K Swindle-Reilly; The Ohio State University, Columbus, OH

878. Halloysite Nanotubes as a Potential Chemotactic Agent for Bone Repair, Y Li*; Louisiana Tech University, Ruston, LA

879. Self-Assembled Peptide Nanorods Embedded in Layer-By-Layer Multilayer Films as Antibacterial Coatings for Hydrogel Contact Lenses, R Chang*, T Webster; Northeastern University, Boston, MA

Orthopaedic Biomaterials SIG

880. Protease Characterization Informs Design of Sustained Release Vehicles for Inhibitors following Rotator Cuff Tear, E. Trevino*, J. McFaline-Figueroa, J. Shah, R. Guldberg, M. Platt, J. Temenoff; Georgia Institute of Technology, Atlanta, GA

881. The Variations in the Electrochemical kinetics of CoCrMo based Hip Implant: Alloy Microstructure and Orientation, D Bijukumar*(1), S Salunkhe(1), J Ehrich(2), S McCarthy(2), D Hall(2), H Lundberg(2), R Pourzal(2), M Mathew(1); (1)University of Illinois College of Medicine, Rockford, IL, (2)Rush University Medical Center, Chicago, IL

882. Understanding Systemic Immune Dysregulation in Severe Trauma and the Effects of Biomaterial-based Interventions, C. Vantucci*, L. Krishnan, A. Cheng, K. Roy, R. Guldberg; Georgia Institute of Technology, Atlanta, GA

883. Generation and Characterization of Wear Debris from Load-Bearing Polymeric Materials, P Turner*(1), P Dean(2), M McDermott(2), E Sussman(2), J Stegemann(1); (1)University of Michigan, Ann Arbor, MI, (2)US Food and Drug Administration, Silver Spring, MD

884. Continuous Fabrication of Collagen Fibers Comprised of Uniaxially Aligned Fibrils: The Second Step for Mimicking Hierarchical Collagen Structure of Tendon, S Yunoki*(1), M Ebisawa(1), H Hatayama(1), E Kondo(2), K Yasuda(3); (1)Tokyo Metropolitan Industrial Technology Research Institute, Tokyo, Japan, (2)Hokkaido University Graduate School of Medicine, Sapporo, Japan, (3)Yagi Orthopaedic Hospital, Sapporo, Ja

885. Osseointegration of Titanium Implants in a Post-Menopausal Osteoporotic Rat Model Treated with Ibandronate, E Lotz*(1), I Nalic(1), R Ellis(2), D Cohen(1), Z Schwartz(1), B Boyan(1); (1)Virginia Commonwealth University, Richmond, VA, (2)University of Virginia, Charlottesville, VA

886. Preliminary Evaluation of Polyethylene Glycol Diacrylate Chitosan for Degradable Antimicrobial Delivery, L. Boles*, W. Haggard, J. Jennings; University of Memphis, Memphis, TN

887. WITHDRAWN

888. Early Diffusion of Biomimetic Proteoglycans Results in Pericellular Augmentation, E Phillips*(1), B Haislup(1), J Sincavage(1), K Prudnikova(1), M Mulcahey(2), M Marcolongo(1); (1)Drexel University, Philadelphia, PA, (2)Tulane University School of Medicine, New Orleans, LA

889. Effect of Covalent Crosslinker Content on Chitosan / Cellulose Nanocrystals Hydrogel Properties, S Aliakbarighavimi*, A Josselet, E Lungren, Y Sun, T Faulkner, Y Wu, F Pfieffer, C Goldstein, C Wan, B Ulery; university of Missouri, Columbia, MO

890. Mechanical Properties of Ossedensification Drilling as Compared to Regular Drilling, F. Gendy*(1), G. Kurgansky(2), L. Cavdar(3), C. Lopez(4), L. Witek(5), P. Coelho(5), A. Torroni(6); (1)Baruch College, New York, NY, (2)Macaulay Honors College at Hunter College, New York, NY, (3)New York Medical College, New York, NY, (4)Icahn School of

891. Improved Bone Stability with the Use of Nitinol Implants in Mid-Foot Applications, L. Actis*(1), D. Petersen(1), J. Ritz(1), E. Marcano(1), D. Castillo(1), K. Ellington(2); (1)DePuy Synthes, San Antonio, TX, (2)DePuy Synthes, Cincinnati, OH, (3)OrthoCarolina, Charlotte, NC

892. A Bioengineered Collagen Meniscus Scaffold, S. Li*, N. Lee, H. Chen; Collagen Matrix, Inc., Oakland, NJ

893. Direct Contact Cytotoxicity Evaluation of CoCrFeNi-based High Entropy Alloys, R. Newell*, I. Arias, A. Mehta, Y. Sohn, S. Florczyk; University of Central Florida, Orlando, FL

894. Investigations of Crystallographic Structure, Antibacterial Efficacy and Bioactivity of Hydroxyapatite Co-Substituted with Selenium and Strontium, M. Maqbool*(1), M. Cresswell(2), P. Jackson(2), P. Basnett(3), I. Roy(3), X. Zhang(2), A. Boccaccini(1); (1)Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany, (2)Lucideon Ltd, Stoke on Trent, United Kingdom, (3)University of Westminster,

895. Controlled Pore Characteristics and Enhanced Pore Interconnectivity of the Porous Titanium (Ti) Scaffolds by Dynamic Freeze Casting via HF/HNO3 Treatment, H Jung*(1),H Lee(2),H Kim(2),T Jang(3); (1)Korea Institute of Industrial Technology, Incheon, Republic of Korea;(2)Seoul National University, Seoul, Republic of Korea;(3)Nanyang Technological University, Singapore, Singapore

896. Evaluation of a Composite of Bioglass, Collagen, Anorganic Bone and Autograft in a Rabbit Spinal Fusion Model, H Chen*, S Li; Collagen Matrix Inc., Oakland, NJ

897. 3D Bioprintable Conductive Nanoinks for Orthopaedic and Spine Applications, T Shokuhfar*; University of Illinos at Chicago, Chicago, IL

898. Engineering Optimally Charged Drug Carriers for Targeting Negatively Charged Tissues, A Vedadghavami*, E Wagner, S Bhakta, S Mehta, D Kim, A Bajpayee; Northeastern University, Boston, MA

899. Corrosion Response of Cobalt Chrome - Titanium 6Aluminum 4Vanadium Modular Taper Connections in Revision Constrained Condylar Knee Femoral Constructs, L Gazza*(1), S Nambu(1), R Obert(2); (1)MicroPort Orthopedics Inc., Arlington, TN, (2)FOCUS Medical Design and Development, Oakland, TN

900. Ultrasound Stimulation of Piezoelectric Composite Harvester with Compliant Layers for Bone Healing, K Coates, E Friis*, E Krech, E Cadel, K Tong, L LaPierre, X Yang; University of Kansas, Lawrence, KS

901. Ascorbic Acid and Calcitriol Effects on Stem Cell Differentiation and Collagen Type on Silk, J Pearson*, G Gonzalez, K Sanchez, J Ong, T Guda; University of Texas at San Antonio, San Antonio, TX

902. Evaluation of Cytotoxicity and Wettability Profile of Bacterial Cellulose-Based Materials Associated with Hydroxyapatite and Anti-BMP-2 Antibodies, T. Capote*, F. Coelho, M. Cavicchioli, S. Specian, R. Caminaga, A. Medeiros, S. Ribeiro; UNESP, Araraquara, Brazil

903. Improving Stiffness & Strength of Double Network Hydrogels towards Synthetic Cartilage, A. Means*, L. Whitney, C. Shrode, M. Grunlan; Texas A&M University, College Station, TX

904. Evaluation of the Bone Repair Potential of Bacterial Cellulose-Based Materials Associated with Hydroxyapatite and Anti-BMP-2 Antibodies, F. Coelho*, M. Cavicchioli, S. Specian, R. Caminaga, S. Ribeiro, T. Capote; UNESP, São Carlos, Brazil

Polymeric Devices in Orthopaedic Applications

905. Polymerization Inhibition of Poly(Methyl Methacrylate) by Rifampin through a Radical Scavenging Mechanism, G. Funk*(1), K. Cole(1), E. Horn(2), K. Kilway(2), T. McIff(1); (1)University of Kansas Medical Center, Kansas City, KS, (2)University of Missouri-Kansas City, Kansas City, MO

906. Injectable Body Heat-Activated Tough Biodegradable Nanocomposites for Regeneration, S. Huddleston*, H. Kim, C. Duan, G. Ameer; Northwestern University, Evanston, IL

907. Comparison of Polyvinylidene Fluoride and Polypropylene Barbed Sutures in Patellar Tendon Repair, Y. Huang*(1), E. Cadet(2), J. Cole(3), M. King(1); (1)North Carolina State University, Raleigh, NC, (2)Raleigh Orthopaedic Clinic, Raleigh, NC, (3)North Carolina State University and University of North Carolina at Chapel Hill, Raleigh, NC

908. Enhanced Bone Regeneration with Tyrosine-Derived Polycarbonate/Beta-Tricalcium Phosphate Scaffolds in a Critical Size Sheep Tibial Model, X Wu*(1), M Shah Mohammadi(1), A Pastino(1), G Pluhar(2), O Ortiz(1), A Merolli(1), J Kohn(1); (1)Rutgers, The State University of New Jersey, Piscataway, NJ, (2)University of Minnesota, Saint Paul, MN

909. In Vitro Wear and Wear Particle Analysis of Conventional Polyethylene Tibial Inserts for Revision Condylar Constrained Knee Systems, A Shivaram*, I Timmerman, S Nambu; MicroPort Orthopedics Inc, Arlington, TN

910. Evaluation of Polyvinyl Alcohol Hydrogel Viscoelasticity or Poroelasticity and Resulting Relative Coefficient of Friction, M Vaughn*(1), K Burg(2), J Corbett(1); (1)Poly-Med, Inc., Anderson, SC, (2)University of Georgia, Athens, GA

911. Long-Term Effects of Vitamin E on the Free Radicals and Luminescence Properties of  Medical-Grade UHMWPE, S. Gomrok*, B. Walters, M. Jahan; The University of Memphis, Memphis, TN

912. WITHDRAWN

913. Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity, D Luong*(1), Y Xu(2), J Walker(3), D Dean(4), M Becker(1); (1)The University of Akron, Akron, OH; (2)Fudan University, Shanghai, China; (3)Youngstown State University, Youngstown, OH; (4)The Ohio State University, Columbus, OH

914. MgO-loading of Poly(glycerol sebacate) to Improve Thermoset Toughness and Mechanical Properties, J Ely*, P Gabriele, B Nicholson, J Harris; Secant Group, LLC, Telford, PA

Protein and Cells at Interfaces SIG

915. Multi-factor Analysis of Initial Synthetic/Protein Content and Remodeling in Engineered Constructs with Raman Spectroscopy, A Theus, K Kerney, J Spano, M Fenn, C Bashur*; Florida Institute of Technology, Melbourne, FL

916. Investigation of Covalently Tethered Interferon-γ Receptor-Ligand Signaling, T. Ham*, S. Christie, A. Smith, N. Leipzig; The University of Akron, Akron, OH

917. Involvement of HMGB1/CD14/MyD88 Axis in the Inflammatory Immune and Healing Response to a  Bone Extracellular/Acellular Matrix Collagen Membrane, E. Silveira, A. Araujo-Pires, C. Biguetti, A. Fonseca, G. Assis, A. Garlet, G. Garlet*; School of Dentistry of Bauru - FOB/USP, Bauru, Brazil

918. Cell Responses on Polyelectrolyte-grafted PEEK Substrates Prepared by a Self-Initiated Photoinduced Polymerization, Y Inoue, K Fukazawa, S Yanokuchi, K Ishihara*; The University of Tokyo, Tokyo, Japan

919. Effect of Integrin Alpha V Silencing on Osteoblastic Differentiation Induced by Titanium with Nanotopography, M Beloti*, H Lopes, G Freitas, P Oliveira, A Rosa; University of Sao Paulo, Ribeirao Preto, Brazil

920. Elucidating Independent and Combinatorial Effects of Gel Diameter and Hydrophobicity on Protein Adsorption, J Clegg*, J Gu, J Sun, M Roy, A Venkataraman, N Peppas; University of Texas at Austin, Austin, TX

Racing for the Surface: Recent Development in Antimicrobial and Osteoinductive Biomaterials

921. Innovative Treatments of Intra- and Extra-Cellular Bacteria using Silver Nanoparticles, B. Li*, J. Kang, K. Hughes; West Virginia University School of Medicine, Morgantown, WV

922. Hydrogel Delivery of Lysostaphin Eliminates Orthopaedic Hardware Infection by Staphylococcus aureus and Supports Fracture Healing, C Johnson*(1), J Wroe(1), R Agarwal(1), K Martin(1), R Guldberg(1), R Donlan(2), L Westblade(3), A García(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Centers for Disease Control and Prevention, Atlanta, GA, (3)Weill Cornell Medical Collage, Ne

923. Inhibition of Bacterial Adhesion on Nano-Textured Stainless Steel 316L by Electrochemical Etching, Y Jang*, W Choi, C Johnson, A García, P Singh, V Breedveld, D Hess, J Champion; Georgia Institute of Technology, Atlanta, GA

924. Collagen-Elastin-like Polypeptide-Bioglass Composite Scaffolds for Bone Tissue Engineering, B. Gurumurthy*, P. Pal, A. Janorkar; University of Mississippi Medical Center, Jackson, MS

925. Antibacterial Tri-Magnesium Phosphate Pentahydrate Coatings on polyetheretherketone (PEEK) Implants by Rapid Microwave Irradiation Technique, P. Sikder*, S. Bhaduri; The University of Toledo, Toledo, OH

926. Multifunctional Titanium Oxide Nanotubular Structures for Osseointegrated Implants, L Rocha*(1), S Alves(2), S Patel(3), A Rossi(4), A Ribeiro(5), C Sukotjo(6), M Mathew(6), P Lisboa Filho(1), J Celis(7), T Shokuhfar(6); (1)UNESP - Universidade Estadual Paulista, Bauru, Brazil, (2)CMEMS - Center of MicroElectroMechanical Systems, Guimara

927. WITHDRAWN

Smart Hydrogels for Cardiovascular Therapy

928. The 3D Functional Biomechanical Impact of Injecting Dual-crosslinking Hydrogels into Myocardium, D Li*(1), R Avaz(1), C Rodell(2), J Burdick(2), J Gorman(2), R Gorman(2), M Sacks(1); (1)The University of Texas at Austin, Austin, TX, (2)University of Pennsylvania, Philadelphia, PA

929. A Polyester Based Hydrogel as Medical Material with Degradable and Photoluminescent Properties, Y Tsou*, X Xu; New Jersey Institute of Technology, Newark, NJ

930. Targeted Three-Layered Micelles and Injectable Hydrogels for Systemic and Local Gene Delivery Systems, T Fujiwara*(1), O Merkel(2); (1)University of Memphis, Memphis, TN, (2)Ludwig-Maximilian University of Munich, Munich, Germany

931. Chitosan-collagen Thermosensitive Hydrogels with Tunable Mechanical Properties for Cell Therapy, E Hui, S Lerouge*; ETS, Montreal, QC

Supramolecular Design of Network Biomaterials

932. Cross-linked Cellulose Nanofibril (CNF) Hydrogels via Thiol-ene Click Reaction as Extracellular Matrix Mimics, N Dadoo*, W Gramlich; University of Maine, Orono, ME

933. The Impact of Inverse Double Networks on Swelling Behavior and Drug Release in Polyvinyl Alcohol- Poly Acrylic Acid Hydrogels, T. Guda, S. Miar*; University of Texas at San Antonio, San Antonio, TX

934. A Computational and Experimental Approach for Designing Co-Assembling Peptides As Recombinant Fusion Tags, D. Seroski*(1), Q. Shao(2), K. Wong(3), A. Paravastu(3), C. Hall(2), G. Hudalla(1); (1)University of Florida, Gainesville, FL, (2)North Carolina State University, Raleigh, NC, (3)Georgia Institute of Technology, Atlanta, GA

935. Spatial Guidance of Microstructured Colloidal Aggregates Controls Endothelial Cells Behavior, Y. Yuan*, D. Sarkar; University at Buffalo, The State University of New York, Buffalo, NY

936. Fibroblast Proliferation Enhanced by Hydrogel Substrate Made from Charge Attraction of Recombinant Spider Silk Protein and Natural Polysaccharides, C Peng*, E Drennon, K Hafner, D Dean, W Marcotte, Jr.; Clemson University, Clemson, SC; Clemson Univresity, Clemson, SC

Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering

937. Multifactorial Design of Modular Peptide Nanofiber Active Immunotherapy to Overcome Self-Tolerance, L. Shores*, J. Collier; Duke University, Durham, NC

938. Tunable Self-assembly of Resilin-like/Elastin-Like Block Copolypeptides as sequence-defined drug delivery carriers, S. Xiong*, M. Dzuricky, I. Weitzhandler, A. Chilkoti; Duke University, Durham, NC

939. Near Infrared Dye-Conjugated Oxidative Stress Amplifying Polymer Micelles for Dual Imaging and Synergistic Anticancer Phototherapy, D Lee*; Chonbuk National University, Jeonju, Republic of Korea

940. Temperature-Responsive Particles from Self-Assembly of Polysaccharides and Elastin-Like Polypeptide Mixtures, J Tang*, S Caliari, K Lampe; University of Virginia, Charlottesville, VA

941. An α-helical Peptide Nanofibers Vaccine for Anti-Tumor Humoral Response, Y Wu*, J Collier; Duke, Durham, NC

942. Therapeutic and Diagnostic Applications of HDL-Mimetic Nanoparticles Engineered in Microfluidics, Y. Sei*(1), J. Ahn(1), E. Shin(1), A. Santiago-Lopez(1), N. Jeon(2), Y. Jang(1), Y. Kim(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Seoul National University, Seoul, Republic of Korea

943. Janus Gold Nanoplates: Dual Coated Amphiphilic Gold Nanoplates for Supramolecular Assembly, E Chowdhury*, R Keynton, M O'Toole; University of Louisville, Louisville, KY

944. Self-assembly Polymer-protein Nanogels Modulate Immune Response through Polymer-mediated Adjuvant Effects, M Mosquera*, T Jing, S Kim, A Singh; Cornell University, Ithaca, NY

945. Drug Release Mechanisms from Nanospheres Investigated using Quartz Crystal Microbalance, A Patel, M Lima, S Murthy*, J Kohn; Rutgers, The State University, Piscataway, NJ

946. In Vitro Cellular Interactions of Multimodal Cellulose Nanocrystal and Lignin Nanoparticles for Drug Delivery Applications, S. Imlimthan*(1), A. Correia(1), V. Balasubramanian(1), P. Figueiredo(1), K. Lintinen(2), A. Airaksinen(1), M. Kostiainen(2), H. Santos(1), M. Sarparanta(1); (1)University of Helsinki, Helsinki, Finland, (2)Aalto University, Espoo, Finland

947. Thixotropic Hydrogels of PEGylated Dendrimer and Alpha-Cyclodextrin for Gene and Drug Delivery, G Williamson*, J Wang, H Yang; Virginia Commonwealth University, Richmond, VA

948. Novel Nanoparticle Capable of Imaging Stem Cell Viability, K Dhada*, L Suggs; University of Texas at Austin, Austin, TX

949. Fabrication of Blue-Fluorescent Nanodiamonds Conjugated with Alkyl Isocyanate for Cellular Bioimaging, R KANG*; The catholic university of korea, Bucheon, Republic of Korea

950. Synthetic high-density lipoprotein nanodiscs for personalized vaccination against glioblastoma multiforme, A Schwendeman,J Moon,L Scheetz*,X Sun; University of Michigan, Ann Arbor, MI

951. Phase Change Material Nanospheres with Nanodiamonds and Chlorin e6 for Photodynamic and Photothermal Tumor Therapy, b Seung-Woon*; The Catholic University of Korea, Buchon, Republic of Korea

952. Polymeric Micelles for Controlled Delivery of Hydrogen Sulfide, U Hasegawa*(1),A van der Vlies(1),I Nakase(2),T Takatani-Nakase(3); (1)Kansas State University, Manhattan, KS;(2)Osaka Prefecture University, Osaka, Japan;(3)Mukogawa Women's University, Hyogo, Japan

Surface Characterization and Modification SIG

953. Fast Imaging and Nanomechanical Charaterization of Cells and Biomaterials by Atomic Force Microscopy, S Kaemmer*(1), M Thompson(1), T Mueller(2); (1)JPK Instruments USA, Carpinteria, CA, (2)JPK Instruments, Berlin, Germany

954. Copper Nanoparticles Assisted Nitric Oxide Releasing Antithrombic and Antibacterial Biomaterial, J Pant*(1), M Goudie(1), S Hopkins(1), E Brisbois(2), H Handa(1); (1)University of Gerogia, Athens, GA, (2)University of Central Florida, Orlando, FL

955. Biodegradable Chitosan/Tannic Acid Polyelectrolyte Coatings with Antibacterial Activity, M Kumorek, I Minisy, M Voršiláková, D Kubies*; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

956. Photoreactive Surface Coating on the Implantable Porous Biomaterials using a Block-Type 2-Methacryloyloxyethyl Phosphorylcholine (MPC) Polymer, S Chen, K Fukazawa, Y Inoue, K Ishihara*; The University of Tokyo, Tokyo, Japan

957. Functionalization of Titanium Surfaces in a Protein Rich Medium, S Rao*(1), M Mathew(1), C Takoudis(2), F Silva(3), S Hashemiastaneh(2), J Souza(3); (1)University of Illinois College of Medicine, Rockford, IL, (2)University of Illinois, Chicago, IL, (3)University of Minho, Guimarães, Portugal

958. Super-Reactive Bromoester Surface Initiator for ATRP Prepared by Glow-Discharge RF Plasma, M Mecwan*, B Ratner; University of Washington, Seattle, WA

959. Osteoblast Viability and Differentiation on Calcium Soaked Titanium Oxides, P. Pal*, H. Johnson, J. Nelson, A. Janorkar, R. Williamson, M. Roach; university of mississippi medical center, Jackson, MS

960. Prevention of Occlusion and Cell Adhesion in 3D-Printed, Liquid-Infused Tympanostomy Tubes, M Le*(1), N Black(2), I Pavlichenko(2), E Kozin(3), A Remenschneider(3), J Aizenberg(2), J Lewis(2); (1)University of Central Florida, Orlando, FL, (2)Harvard University, Cambridge, MA, (3)Massachusetts Eye and Ear Infirmary and Harvard Medical School, Bo

961. Fast Calcium Phosphate Deposition on Polyetheretherketone through Simple Chemistry, A. Wen*(1), H. Wen(2), Y. Kang(3); (1)Florida Atlantic University, Lake Worth, FL, (2)Zimmer Biomet, Lake Worth, FL, (3)Florida Atlantic University, Boca Raton, FL

962. WITHDRAWN

963. QAC-Dendrimer and Chitosan Antimicrobial Finishing of Hernia Mesh, J Wang*(1), A Brown(2), W Krause(1), M King(1); (1)North Carolina State University, Raleigh, NC, (2)NC State University/UNC-Chapel Hill, Raleigh, NC

964. Quantification of Hydroxyl Ion Concentration in Hydroxyapatite, L Pluduma*(1), K Gross(1), C Rey(2); (1)Riga Technical University, Riga, Latvia; (2)University of Toulouse, Toulouse, France

965. Polymer Brush Modified Capillary Microfluidics for Efficient Capture of Circulating Tumor Cells, Y Zheng*; Northeastern University, Boston, MA

966. Surface Modification of Electrospun Polymer Tubular Conduits using Low Temperature Reduced Pressure Plasma, B Tucker*, P Baker, Y Vohra, V Thomas; The University of Alabama at Birmingham, Birmingham, AL

Therapeutic Strategies for the Treatment of Infectious Diseases

967. In Vitro Testing of a First-in-class Antibiotic used in an Anti-biofilm Coating, N Ashton*, G Allyn, R Epperson, T Haussener, H Reddy, R Looper, D Williams; The University of Utah, Salt Lake City, UT

968. Peptide-Enriched Nanocarriers for the Growth Inhibition of Antibiotic-Resistant Bacteria, N Bassous*, T Webster; Northeastern University, Boston, MA

969. Broad Spectrum Antibiotic Self-Assembling Peptides, B. Sarkar*, S. Jaisinghani, P. Nguyen, V. Kumar; New Jersey Institute of Technology, Newark, NJ

970. Evaluation of the Antimicrobial and Potentiation Activity of Cationic Polyrotaxanes against Escherichia coli, J Qiao*, Z Liu, M Xiong; University of Georgia, Athens, Georgia

Tissue Engineering SIG

971. Growth Factor-encapsulated and Cell-laden Nanofibrous Bilayer Scaffolds for Vascular Regeneration, Y Zhou, H Sun*, M Wang; The University of Hong Kong, Hong Kong, Hong Kong

972. 3D Alginate Hydrogel Matrix for Cell Encapsulation and Long-Term Preservation, S. Khanal*; North Carolina A&T State University, Greensboro, NC

973. Bijels-derived Hybrid Hydrogel Membranes and Growth Factor Delivery, H Sun*, J Li, M Wang; The University of Hong Kong, Hong Kong, Hong Kong

974. Biphasic Calcium Phosphate Bioceramics for Facial Recontour: in vitro, in vivo and Clinical Outcomes, S. Lobo*(1), O. Moreira Filho(2), F. Wykrota(3); (1)Hospital das Clínicas, São Paulo, Brazil, (2)Hospital Santa Casa, Belo Horizonte, Brazil, (3)EINCO Biomaterial Ltda, Belo Horizonte, Brazil

975. Immunoisolating poly(ethylene glycol) Based Capsules Support Ovarian Tissue Survival to Restore Endocrine Function, J Day*, A David, A Cichon, T Kulkarni, M Cascalho, A Shikanov; University of Michigan, Ann Arbor, MI

976. Effect of Raspberry Ketone-Loaded Chitosan Membranes on Saos-2 Cell Growth, P. Cameron*, H. Su, V. Murali, F. Delbuque Guerra, J. Bumgardner; University of Memphis, Memphis, TN

977. Evaluation of Heparin-Collagen Layer-by-Layer films as Nerve Growth Factor Reservoirs, L Pinzon*, A Mulero, J Almodovar; University of Puerto Rico, Mayaguez, Puerto Rico

978. Biological Differences of Human Mesenchymal Cells Derived from Different Bone Tissues and Comprehensive Gene Expression Analysis, Y. Yamazaki*; Kitasato University School of Medicine, Sagamiharu, Japan

979. Histological Evaluations of the Effects of Diabetes on Renal Vasculature, D Pollard*; Clemson University, Greenville, SC

Translation of Nanoparticle Contrast Agents for Clinical X-Ray Imaging Modalities

980. Labelling Low Density Lipoprotein with Gold Nanoparticles or Iodine Prevents Uptake in U937 cells, H. Prebble*(1), E. Searle(1), R. Aamir(2), N. Anderson(2), A. Butler(2), S. Gieseg(1); (1)University of Canterbury, Christchurch, New Zealand, (2)University of Otago, Christchurch, New Zealand

981. Hydrothermal Synthesis and Characterization of Hafnium Oxide (HfO2) Nanoparticles for Biomedical Applications, T. McGinnity*(1), V. Sokolova(2), O. Prymak(2), M. Epple(2), R. Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)University of Duisburg-Essen, Essen, Germany

982. Radiographic Phantom Mimicking Varying Levels Breast Tissue Density for Translational Investigation of Contrast-Enhanced Detection of Breast Microcalcifications, T Finamore*(1), L Irimata(1), E Gies(1), T Vargo-Gogola(2), R Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)Indiana School of Medicine, Indianapolis, IN

983. Engineered T-cell Cancer Immunotherapy Tracking with X-Ray Computed Tomography, J. Kim*, P. Chhour, A. Silva, H. Shin, A. Posey, D. Cormode; University of Pennsylvania, Philadelphia, PA

984. Cytocompatibility of Hafnium Oxide Nanoparticle Imaging Probes Prepared Using a Novel Templated Synthesis, P Nallathamby*(1), V Sokolova(2), O Prymak(2), M Epple(2), R Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)University of Duisburg-Essen, Essen, Germany

985. Development of Spectral Photon-Counting CT Specific Contrast Agents and Ultra-Small Tantalum Oxide Nanoparticles, J. Kim*(1), D. Bar-Ness(2), S. Si-mohamed(2), P. Douek(2), D. Cormode(1); (1)University of Pennsylvania, Philadelphia, PA, (2)University Lyon1 Claude Bernard, Bron, France

986. Non-Invasive, Longitudinal Measurement of Collagen Scaffold Degradation Using Computed Tomography and Gold Nanoparticles, T Finamore*(1), T Curtis(1), J Tedesco(2), K Grandfield(2), R Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)Mcmaster University, Hamilton, ON

987. Ultrasmall Glutathione-Coated Silver Sulfide Nanoparticles for Breast Cancer Screening with Dual-Energy Mammography or Computed Tomography, J. Hsu*, K. Lau, E. Cruz, A. Maidment, D. Cormode; University of Pennsylvania, Philadelphia, PA

988. Quantification of Mixed Contrast Agents and Material Compositions Using Photon-Counting Spectral CT, T. Curtis*, R. Roeder; University of Notre Dame, Notre Dame, IN

989. Wulff in a Cage Gold Nanoparticles as Contrast Agents for Computed Tomography and Photoacoustic Imaging, M. Hajfathalian*(1), A. Amirshaghaghi(1), P. Chhour(1), P. Naha(1), J. Hsu(1), S. Neretina(2), D. Cormode(1); (1)University of Pennsylvania, Drexel Hill, PA, (2)University of Notre Dame, South Bend, IN

990. Effect of Antibody Density on Immunotargeting and Radiographic Detection of HER2+ Breast Cancer Cells with Au@SiO2 NPs, T. McGinnity*, T. Vargo-Gogola, R. Roeder; University of Notre Dame, South Bend, IN