Rapid Fire: Biomaterials and Scaffolds for Interfacial Tissue Engineering

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Tissue Engineering
Room: Grand Ballroom D


Musculoskeletal tissue interfaces are complex, heterogeneous tissues in which the specific spatial composition is tightly linked to biological function. Biomaterials for interfacial tissue engineering must therefore be designed to guide biomimetic tissue organization to regenerate functional constructs. This session will focus on novel biomaterials-based strategies to regenerate musculoskeletal interfaces with particular attention to approaches to control the spatial organization of chemical and/or physical cues to direct cell and tissue response locally and globally within a scaffold. These include advanced scaffold fabrication, biochemical functionalization, scaffold-cell interactions, physical and structural cues, spatial growth factor control, and stem cell lineage commitment for musculoskeletal tissue interface regeneration.


  • 3:15 p.m. 78. Biomimetic Hydrogel Supports the Development of Murine Primary Ovarian Follicles Co-cultured with Human Adipose Derived Stem Cells, C. Tomaszewski*, H. Zhou, E. Constance, A. Shikanov; University of Michigan, Ann Arbor, MI

  • 3:20 p.m. 79. Micropatterned graphene-incorporated conductive hydrogels produced by Femtosecond laser ablation for potential skeletal muscle tissue engineering applications, J. Park*, J. Lee; Gwangju Institute Science and Technology (GIST), Gwangju, Republic of Korea

  • 3:25 p.m. 80. 3D Printed Bioactive Ceramic Scaffolds Coated with Dipyridamole Regenerate Vascularized Bone Without Suture Fusion in Alveolar Cleft Defects, C. Lopez*(1), F. Gendy(1), L. Witek(1), S. Maliha(2), R. Flores(2), L. Cavdar(1), A. Torroni(2), J. Bekisz(2), B. Cronstein(2), P. Coelho(1); (1)New York University, New York, NY, (2)NYU School of Medicine, New York, NY

  • 3:30 p.m. 81. MSC Spheroid Laden Amorphous Silica Fiber Matrix for Osteochondral Regeneration, H Kim*(1), M Hu(2), S Nukavarapu(2); (1)University of Connecticut, Storrs, CT, (2)University of Connecticut Health, Farmington, CT

  • 3:35 p.m. 82. Extracellular Matrix Paper (ECM-paper) for Construction of Multi-layered Blood vessel wall tissues, H. Nakatsuji*, M. Matsusaki; Graduate school of engineering, Osaka University, Suita, Japan

  • 3:45 p.m. 83. Bioinspired Fibrin Microthreads Deliver FGF2 to Guide in vitro Skeletal Muscle and Endothelial Cell Function, M Carnes*, K Castellano, G Pins; Worcester Polytechnic Institute, Worcester, MA

  • 3:50 p.m. 84. PCL-Chitosan-Magnesium Oxide Based Composite Nanofibers for Tissue Engineering Applications, U. Adhikari*; North Carolina A&T State University, Greensboro, NC

  • 3:55 p.m. 85. Electrospun Poly(?-caprolactone) Nanofiber Shish Kebabs Mimic Mineralized Collagen Fibrils in Bone, T Yu*, M Marcolongo, C Li; Drexel University, Philadelphia, PA

  • 4:00 p.m. 86. Opposing Mineral and Protein Gradients in a Nanofiber Scaffold Promotes Spatial Cellular Response, S Patel*(1), K Schutt(1), D Qu(1), A Deymier(1), S Doty(2), S Thomopoulos(1), H Lu(1); (1)Columbia University, New York, NY, (2)Hospital for Special Surgery, New York, NY

  • 4:05 p.m. 87. GermanyGeneration of Rapid In Situ Forming Channels within Soft Biomaterials via Biodegradable Fiber Porogens, A Chen*, D Puleo; University of Kentucky, Lexington, KY

  • 4:15 p.m. 88. Biologically Inspired Osteoinductive Scaffolds with Drug Eluting Spheres, E. Mondragon*(1), M. Cowdin(1), F. Taraballi(2), E. Tasciotti(2), R. Kaunas(1); (1)Texas A&M University, College Station, TX, (2)Houston Methodist, Houston, TX

  • 4:20 p.m. 89. A High-Throughput Microchannel Scaffold Fabrication Technique, D Shahriari*, Y Fink, P Anikeeva; Massachusetts Institute of Technology, Cambridge, MA

  • 4:25 p.m. 90. Electrochemical Manipulation of a Cell Monolayer Supported by a Biodegradable Polymeric Nanosheet for Cell Transplantation Therapy, H. Kaji*, J. Suzuki, N. Nagai, T. Abe; Tohoku University, Sendai, Japan

  • 4:30 p.m. 91. Treatment of Osteoarthritis Using Macrophage-Targeting Hyaluronic Acid Microscaffolds, S Li, J Zhou, A Hakamivala, Y Huang, W Cong, J Borrelli, L Tang*; University of Texas at Arlington, Arlington, TX

  • 4:35 p.m. 92. 3D Printing Spatially Organized Scaffolds for Osteochondral Interface Regeneration, H. Busari*, P. Schwarzenberg, P. Camacho, K. Hudson, H. Dailey, L. Chow; Lehigh University, Bethlehem, PA

Rapid Fire: Biomaterials for Regenerative Engineering Applications

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Tissue Engineering
Room: Grand Ballroom C


Regenerative Engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and clinical translation to develop innovative, scalable tools to regenerate damaged or diseased complex tissues and organs. This symposium will include presentations that describe how biomaterials inspired from the fields of nanotechnology, cell and molecular biology, and medicine can improve health. The session will cover how clinical translation may/should drive biomaterial design by fostering discussion among clinician/scientists, engineers, and representatives from companies with interest in tissue engineering and regenerative medicine.


  • Vascular

  • 3:15 p.m. 63. Probing Mechanisms of Matrix Remodeling During Capillary Morphogenesis using Protease-selective Hydrogels, B Juliar*, J Beamish, A Putnam; University of Michigan, Ann Arbor, MI

  • 3:20 p.m. 64. Pre-vascularized Human Mesenchymal Stem Cell Sheets for Full Thickness Skin Wound Repair, F Zhao*(1), L Chen(2), Q Xing(1), M Tahtinen(1), S Qi(2); (1)Michigan Technological University, Houghton, MI, (2)First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

  • 3:25 p.m. 65. Engineering patent vasculature of decellularized liver scaffolds for transplantation, F. Meng*, F. Almohanna, A. Altuhami, A. Assiri, D. Broering; King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

  • 3:30 p.m. 66. A Multiscale System for Injectable Co-delivery of EGF and Stem Cells to Treat Ischemic Diseases, H Wang*, X He; The Ohio State University, Columbus, OH

  • 3:35 p.m. 67. Encapsulation of Endothelial Colony Forming Cells in Injectable Hydrogel Microspheres for Cell Delivery, Y Tian*, W Seeto, R Winter, F Caldwell, A Wooldridge, E Lipke; Auburn University, Auburn, AL

  • Muscle, Nerve, and Skin

  • 3:45 p.m. 68. Synthetic Bioadhesive Matrix Facilitates Satellite Cell Transplantation and Engraftment in Dystrophic Diaphragm, W. Han*, S. Anderson, M. Mohiuddin, Y. Jang, A. García; Georgia Institute of Technology, Atlanta, GA

  • 3:50 p.m. 69. Therapeutic Potential of Bioengineered Skeletal Muscle with Spatially Patterned Structure and Endothelial Support, K Nakayama*(1), M Quarta(2), P Paine(2), C Alcazar(2), V Garcia(2), O Abilez(1), N Calvo(3), C Simmons(3), T Rando(1), N Huang(1); (1)Stanford University, Palo Alto, CA, (2)Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, (3)University of Flo

  • 3:55 p.m. 70. Using Methacrylic Acid Based Biomaterials for Endogenous Repair of Skeletal Muscle, M Carleton*, R Mahou, M Sefton; University of Toronto, Toronto, ON

  • 4:00 p.m. 71. Methacrylic Acid Based Biomaterials for Peripheral Nerve Regeneration, A Androschuk*, R Mahou, I Talior-Volodarsky, M Sefton; Institute of Biomaterials and Biomedical Engineering, Toronto, ON

  • 4:05 p.m. 72. Poly(3-hydroxybutyrate-co-3-hydroxy valerate) nanofibrous scaffold for skin tissue engineering, A Loordhuswamy*, D Sundaramoorthy, A Subramanian, U Krishnan, S Sethuraman; SASTRA UNIVERSITY, Thanjavur, India

  • Bone, Cartilage, and Ligaments

  • 4:15 p.m. 73. Regenerative Engineering of Bone: In Vivo Evaluation of Next Generation Inductive Graphene-Ceramics, L Daneshmandi*(1), S Gohil(2), L Nair(2), A Arnold(3), B Holt(3), S Sydlik(3), C Laurencin(1); (1)University of Connecticut, Farmington, CT, (2)UConn Health, Farmington, CT, (3)Carnegie Mellon University, Pittsburgh, PA

  • 4:20 p.m. 74. Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions, M Trombold*(1), S Bryant(2); (1)The University of Texas at Austin, Austin, TX, (2)The University of Colorado Boulder, Boulder, CO

  • 4:25 p.m. 75. Prevascularization of Mesenchymal Stem Cell Sheets for Bone Tissue Regeneration, W. Jia*(1), Q. Xing(1), M. Tahtinen(1), F. Zhao(1); Michigan Technological University, Houghton, MI

  • 4:30 p.m. 76. Anterior Cruciate Ligament Matrix Inspired by Clinical Application: An In Vivo Assessment, P. Mengsteab*, P. Conroy, M. Badon, H. Kan, L. Nair, C. Laurencin; University of Connecticut, Farmington, CT

  • 4:35 p.m. 77. Ultrasmall Superparamagnetic Iron Oxide Nanoparticles as T1 MRI Contrast Agents in Articular Cartilage Imaging, J. Wu*; Sichuan University, ChengDu, China

Rapid Fire: Drug Delivery

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Drug Delivery
Room: Grand Ballroom B


The Drug Delivery SIG session will consider abstracts that fall with the broad areas of therapeutic development, formulation, and application testing. Drug delivery from medical devices, tissue engineering scaffolds/hydrogels, films, microparticles, nanoparticles, environmentally responsive materials, and other types of biomaterial assemblies are all invited. Studies testing drug targeting, drug combinations, and drug/cell combinations are all also welcomed to submit. Drug delivery application areas of interest include but are not limited to regenerative medicine/tissue engineering, cell and tissue transplant, cardiovascular stents and other devices, cancer, microbial infection, and autoimmune diseases.


  • Nanoparticles

  • 3:15 p.m. 93. Intestinal Organoids Containing PLGA Nanoparticles for the Treatment of Inflammatory Bowel Diseases, Z. Davoudi*, N. Peroutka-Bigus, B. Bellaire, M. Wannemuehler, B. Narasimhan, Q. Wang; Iowa State University, Ames, IA

  • 3:20 p.m. 94. Modular Nanoparticle Scaffolds for Tunable Drug Delivery, K Peuler*, C Lin; Indiana University Purdue University Indianapolis, Indianapolis, IN

  • 3:25 p.m. 95. EPITOPE-FUNCTIONALIZED NANOPARTICLES FOR ENTRAPMENT OF AUTISM AUTO-ANTIBODY, A Bolandparvaz*(1), E Edmiston(2), K Alvarez(1), J Van De Water(1), J Lewis(1); (1)UC Davis, Davis, CA, (2)Blueprint Research, San Francisco, CA

  • 3:30 p.m. 96. Tailoring Swelling pH of Poly(Sialic Acid) Micelles Based on Core Hydrophobicity, G Pawlish*(1), N Comolli(2), K Spivack(2); (1)Temple University, Philadelphia, PA, (2)Villanova University, Villanova, PA

  • 3:35 p.m. 97. Chitosan/Poly(lactide) Drug-Loaded Nanoparticles for Delivery of Therapeutic Compounds, S. DeVeaux*, C. Gomillion; University of Georgia, Athens, GA

  • Cancer

  • 3:45 p.m. 98. Leukocytes as Mobile Carriers of Anti-Cancer Therapeutics via Bispecific Liposomes, Z Zhang*, D Liu, N Ortiz-Otero, T Cao, M King; Vanderbilt University, Nashville, TN

  • 3:50 p.m. 99. A Poly (Lactic-co-glycolic Acid)-based Phase-separating Platform for Controlling the Kinetics of Combinatorial Therapeutics in Ovarian Cancer, S Arun Kumar*, W Souery, Y Jhan, C Bishop; Texas A&M University, College Station, TX

  • 3:55 p.m. 100. Folic Acid Modified Halloysite Nanotubes with Tumor Targeting Capability, Y. Luo*, D. Mills; Louisiana Tech University, Ruston, LA

  • 4:00 p.m. 101. Silk Carriers for Local Delivery of Cisplatin: In Vitro Release Kinetics, B. Yavuz*(1), K. Harrington(1), J. Coburn(2), B. Chiu(3), D. Kaplan(1); (1)Tufts University, Medford, MA, (2)Worcester Polytechnic Institute, Worchester, MA, (3)University of Illinois at Chicago, Chicago, IL

  • 4:05 p.m. 102. Methacrylation of Chondroitin Sulfate for Drug Delivery Applications, K. Ornell*, J. Coburn, N. Phan, W. Linthicum, D. Lozada; Worcester Polytechnic Institute, Worcester, MA

  • Tissue Engineering

  • 4:15 p.m. 103. Biodegradable simvastatin-containing polymeric prodrugs with improved drug release and their application as porous scaffolds for tissue engineering, A Liyanage*, N Venkatesan, D Puleo; University of Kentucky, Lexington, KY

  • 4:20 p.m. 104. Synthesis and characterization of polyethylene (PEG) incorporated hyaluronic acid hydrogels for tissue engineering, J Kim, J Kim*; Hongik University, Sejong, Republic of Korea

  • 4:25 p.m. 105. Sequential Delivery of Ketoprofen and Captopril from a Multilayered Poly(?-amino ester) System for Muscle Repair, N Venkatesan*, D Puleo; University of Kentucky, Lexington, KY

  • 4:30 p.m. 106. Multiple growth factor loading strategy affects spatiotemporal release from heparin microparticles, R. Subbiah*, L. Krishnan, R. Guldberg; Georgia Institute of Technology, Atlanta, GA

  • 4:35 p.m. 107. Development of a bi-modal, in situ crosslinking method to achieve multi-factor release from electrospun gelatin, A Kishan*(1), T Walker(2), N Sears(1), T Wilems(2), E Cosgriff-Hernandez(2); (1)Texas A&M University, Houston, TX, (2)University of Texas, Austin, TX

Rapid Fire: Engineered Biomaterials for Neural Applications

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Biomaterials Applications
Room: 206/207


Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.


  • Controlled Release

  • 3:15 p.m. 123. Perfusion Stabilizes Long-Term Barrier Function of iPSC-derived Brain Endothelial Cells in 3D Hydrogel Channels, S Faley*, E Hollmann, J Wang, A Bosworth, C Weber, E Lippmann, L Bellan; Vanderbilt University, Nashville, TN

  • 3:20 p.m. 124. Transient blood brain barrier disruption extends therapeutic window for nanoparticle after brain injury, V. Bharadwaj*(1), T. Anderson(2), J. Lifshitz(2), V. Kodibagkar(1), S. Stabenfeldt(1); (1)Arizona State University, Tempe, AZ, (2)University of Arizona, College of Medicine-Phoenix, Phoenix, AZ

  • 3:25 p.m. 125. Electrospun Fibers for Application in Neural Tissue Engineering under Controlled Release, J Xue*, Y Xia; Georgia Institute of Technology, Atlanta, GA

  • 3:30 p.m. 126. Mechanical Properties and PDGF-AA Release Kinetics of a 3D Hydrogel-Microparticle Drug Delivery System Guide Oligodendrocyte Precursor Cell Proliferation and Differentiation, M. Pinezich, L. Russell, N. Murphy, K. Lampe*; University of Virginia, Charlottesville, VA

  • 3:35 p.m. 127. Drug Loaded Polymer Scaffolds for Treatment of Post-Surgical Glioblastoma, E Graham-Gurysh*(1), K Moore(2), E Bachelder(1), C Miller(1), K Ainslie(1); (1)University of North Carolina at Chapel Hill, Chapel Hill, NC, (2)UNC Chapel Hill and North Carolina State University, Chapel Hill, NC

  • Engineered Biomaterials for Neural Applications

  • 3:45 p.m. 128. Subcutaneous maturation of adult NSC-loaded biomaterial scaffolds to spinal cord regionalized neuroepithelium, M Farrag*, N Leipzig; The University of Akron, Akron, OH

  • 3:50 p.m. 129. A Biomaterial for the Prevention of Epidural Fibrosis, S Ing*(1), M Cooke(1), C Tator(2), M Shoichet(1); (1)University of Toronto, Toronto, ON, (2)Toronto Western Hospital, Toronto, ON

  • 3:55 p.m. 130. Sulfated Chondroitin Sulfate Glycosaminoglycan Hydrogel Carriers Improve Transplanted Cell Survival and Enhance Regeneration after Ischemic Stroke in Mice, M. McCrary*(1), K. Jesson(1), G. Sethaputra(1), X. Gu(1), L. Karumbaiah(2), S. Yu(1), L. Wei(1); (1)Emory University, Atlanta, GA, (2)The University of Georgia, Athens, GA

  • 4:00 p.m. 131. Polyvinylpyrrolidone (PVP) dexamethasone controlled release for treatment of neural inflammation after CNS injury, J Johnson*, T Zhao, R Saigal; University of Washington, Seattle, WA

  • 4:05 p.m. 132. Addressing the Effect of DNase Treatment on ECM Preservation and Cell Removal during Sodium Deoxycholate Based Chemical Decellularization of Peripheral Nerve, M. (Mertz) McCrary*, N. Vaughn, Y. Song, C. Schmidt; University of Florida, Gainesville, FL

  • Peripheral Nerves

  • 4:15 p.m. 133. Freeze-cast Core-shell Scaffolds for 10 mm Peripheral Nerve Repair in Rats Sciatic Model, K. Yin*, P. Divakar, J. Hong, K. Moodie, J. Rosen, M. Matthew, U. Wegst; Dartmouth College, Hanover, NH

  • 4:20 p.m. 134. Optimizing Schwann Cell Migration Using Laminin Derived-peptides to Improve Nerve Regeneration, C. Motta*, R. Willits, M. Becker; The University of Akron, Akron, OH

  • 4:25 p.m. 135. Scaling implants from in vivo models to clinical relevance for peripheral nerve repair, K Pawelec*(1), J Koffler(2), A Galvan(1), M Tuszynski(2), J Sakamoto(1); (1)University of Michigan, Ann Arbor, MI, (2)University of California San Diego, La Jolla, CA

  • 4:30 p.m. 136. Preparation and Characterization of Magnetically Templated Hydrogels for Peripheral Nerve Injury Repair, I Singh*, C Lacko, C Schmidt, C Rinaldi; University of Florida, Gainesville, FL

  • 4:35 p.m. 137. Development of an injectable device for peripheral nerve repair, T Prest, C Skillen, C Heisler, K Labelle, R Hartogs, B Brown*; University of Pittsburgh, Pittsburgh, PA

Rapid Fire: Engineered Microenvironments to Model Disease

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular responses to disease/injury, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.


  • Musculoskeletal Disease

  • 3:15 p.m. 153. WITHDRAWN

  • 3:20 p.m. 154. A 3D in vitro Osteoarthritis Model to Evaluate the Therapeutic Potential of Human Mesenchymal Stem Cells, P Diaz-Rodriguez*, H Chen, S Samavedi, M Hahn; Rensselaer Polytechnic Institute, Troy, NY

  • 3:25 p.m. 155. The Role of Mechanotransduction on Myoblasts in Muscle Injury Using Dynamically Stiffening Polymers, J. Silver*(1), T. Brown(1), T. Vogler(1), F. DelRio(2), A. Mckay(1), B. Olwin(1), K. Anseth(1); (1)University of Colorado, Boulder, Boulder, CO, (2)National Institute of Standards and Technology, Boulder, CO

  • 3:30 p.m. 156. Mimicking Paracrine Signals between Macrophages and Fibroblasts in a 3D Wound Healing Model in vitro, F. Ullm, M. Ansorge, J. Sapudom, K. Franke, T. Pompe*; University of Leipzig, Leipzig, Germany

  • 3:35 p.m. 157. Engineering of an In Vitro Model of Discogenic Low Back Pain, S. Romereim*, E. Johnson, R. Wachs; University of Nebraska-Lincoln, Lincoln, NE

  • Cancer

  • 3:45 p.m. 158. Mechanobiologically-modulated microniches for investigation of angiogenesis induced liver fibrosis and drug testing, L. Liu*; Tsinghua University, Beijing, China

  • 3:50 p.m. 159. Matrix Adhesivity and Stiffness Regulate Metastatic Breast Cancer Dormancy, S. Pradhan*, M. Chatterjee, J. Slater; University of Delaware, Newark, DE

  • 3:55 p.m. 160. Fibrous topography promotes cell spreading and migration in 3D, D Matera*, B Baker; University of Michigan, ann arbor, MI

  • 4:00 p.m. 161. Synthetic Hydrogels with Highly Bioactive Basement Membrane Functionality, R. Wilson*, G. Swaminathan, K. Grande-Allen; Rice University, Houston, TX

  • 4:05 p.m. 162. Decoupling the Impact of Hydrogel Stiffness and Mesh Size for Studying Matrix Metalloproteinase-Mediated Behavior of Metastatic Breast Cancer Cells, A. Narkhede*, S. Rao; The University of Alabama, Tuscaloosa, AL

  • 4:15 p.m. 163. Biomaterials Models of Glioblastoma Microenvironment, W Xiao, A Sohrabi, Y Ghochani, A Ehsanipour, R Zhang, S Sun, L Ta, H Kornblum, D Nathanson, S Seidlits*; University of California Los Angeles, Los Angeles, CA

  • 4:20 p.m. 164. Polymer Scaffolds for Early Detection and Vaccination Against Metastatic Breast Cancer, Y. Zhang*, K. Hughes, R. Oakes, G. Bushnell, R. Hartfield, M. Cascalho, J. Platt, J. Jeruss, L. Shea; University of Michigan, Ann Arbor, MI

  • 4:25 p.m. 165. In Vitro Bioengineered Prostate Tumor Model for Recapitulation of the Native Tumor Microenvironment, N. Habbit*(1), B. Anbiah(1), I. Hassani(1), M. Eggert(1), S. Jasper(1), B. Prabhakarpandian(2), R. Arnold(1), E. Lipke(1); (1)Auburn University, Auburn, AL, (2)CFD Research Corporation, Huntsville, AL

  • 4:30 p.m. 166. Three-Dimensional Engineered Tumor Tissues Using Patient-Derived Colorectal Cancer Xenografts, I Hassani*, B Anbiah, B Ahmed, N Habbit, M Greene, E Lipke; Auburn University, Auburn, AL

  • 4:35 p.m. 167. Effect of 3D Porous Chitosan-Alginate Scaffold Stiffness on Prostate Cancer Malignancy, K. Xu*(1), K. Ganapathy(1), T. Andl(1), Z. Wang(1), J. Copland(2), R. Chakrabarti(1), S. Florczyk(1); (1)University of Central Florida, Orlando, FL, (2)Mayo Clinic, Jacksonville, FL

Rapid Fire: Fabrication and 3D Printing of Tissue Engineering Scaffolds

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


The field of tissue engineering relies extensively on the use of 3D scaffolds to provide the appropriate microenvironment for tissue regeneration. This session will focus on the state-of-the-art technologies including 3D printing and related methods in the development of biomimetic materials and scaffolds and the application of these scaffolds to modulate desirable cellular responses and various tissue regeneration.


  • 3:15 p.m. 48. Evaluation of Chitosan-based Hydrogel as a Bioprinting Material for Vocal Fold Tissue Engineering, G Bao*, T Jiang, H Ravanbakhsh, H Wang, J Kinsella, L Mongeau; McGill University, Montreal, QC

  • 3:20 p.m. Response of Bioprinted Neuroblastoma to Electrical Stimulation, K Roehm*, S Madihally; Oklahoma State University, Stillwater, OK

  • 3:25 p.m. 50. Orthogonally Programmable Stiffness and Geometry in 3D Hydrogel Microstructures by Digital Projection Stereolithography, Y Ding*, H Yin, W Tan, X Yin; University of Colorado Boulder, Boulder, CO

  • 3:30 p.m. 51. Stereolithographic 3D Printing of Mechanically Enhanced Constructs for the Treatment of Pediatric Physeal Injuries, A Uzcategui*(1), Y Yu(2), A Muralidharan(1), K Payne(2), R McLeod(1), S Bryant(1); (1)University of Colorado at Boulder, Boulder, CO, (2)University of Colorado Anschutz Medical Campus, Aurora, CO

  • 3:35 p.m. 52. Development of new binder jetting process for fabricating bone regeneration implants, M. Watanabe*(1), Y. Tsujimura(2), S. Oyama(3), K. Yamazawa(1), H. Yokota(1); (1)RICOH, Kanagawa prefecture, Japan, (2)RIKEN, Saitama prefecture, Japan, (3)Nagoya University, Saitama prefecture, Japan

  • 3:45 p.m. 53. Stem Cell Niche Generation through Shear Stress, Spatial Patterning of Proliferation, Differentiation, and Cocultures, J. Lembong(1), M. Lerman*(1), T. Kingsbury(2), C. Civin(2), J. Fisher(1); (1)University of Maryland, College Park, MD, (2)University of Maryland School of Medicine, Baltimore, MD

  • 3:50 p.m. 54. Shape-fitting Mineralized Collagen-PLA Composite for Cranio-Maxillofacial Bone Regeneration, M. Dewey*, E. Johnson, M. Wheeler, B. Harley; University of Illinois at Urbana Champaign, Urbana, IL

  • 3:55 p.m. 55. Manipulating bioink chemistry and mechanical properties for long-term cell health after 3D printing of gel-phase bioinks, E. Gargus*, A. Rutz, K. Hyland, P. Lewis, A. Setty, R. Shah; Northwestern University, Chicago, IL

  • 4:00 p.m. 56. 3D Printing Thermosensitive Polymers: The Development of Filament-Based Direct Writing Melt Electrospinning, J. Steele*, A. March, J. Molde, J. Kohn; Rutgers University, Piscataway, NJ

  • 4:05 p.m. 57. Issues in Fabrication and 3D Printing of Tissue Engineering Scaffolds from Degradable Polymers, S Murthy*, J Kohn; Rutgers, The State University, Piscataway, NJ

  • 4:15 p.m. 58. Alginate/gelatin as a bioprinting ink to tailor tumor spheroid formation, T Jiang*(1), J Munguia-Lopez(1), S Flores Torres(1), J Kort Mascort(1), K Gu(1), M Bavoux(2), J Kinsella(1); (1)McGill University, Montreal, QC, (2)Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, France

  • 4:20 p.m. 59. 3D-Printed Polylactic Acid Scaffold for Regenerative Implant Integration Applications, E Yenner(1), K Kumar(1), D Wetknight(1), A Neiman(1), N Wancio(1), M Frohbergh*(2); (1)Drexel University, Philadelphia, PA, (2)Exponent Inc., Philadelphia, PA

  • 4:25 p.m. 60. Development and Mechanical Characterization of Composite ß-TCP Bioinks For Their Use in Biomedical Applications, S. Montelongo*, G. Chiou, S. Miar, T. Guda; University of Texas at San Antonio, San Antonio, TX

  • 4:30 p.m. 61. Dipyridamole Enhances Bone Regenerative Capacity of 3D Printed Scaffolds at the Upper Extremity in a Dose Dependent Manner, L. Witek*(1), C. Lopez(2), N. Tovar(1), M. Bowers(1), B. Cronstein(3), P. Coelho(1); (1)New York University, New York, NY, (2)Icahn School of Medicine at Mount Sinai, New York, NY, (3)New York University School of Medicine, New York, NY

  • 4:35 p.m. 62. An intrinsic angiogenesis approach and varying bioceramic scaffold architecture affect blood vessel formation in bone tissue engineering in vivo, C Knabe*(1), M Kampschulte(2), B Peleska(1), R Gildenhaar(3), G Berger(3), C Gomes(3), U Linow(3), J Guenster(3), A Houshmand(1), M Stiller(1), K Abdel Ghaffar(4), A Gamal(4), M EL-Mofty(4), D Adel-Khattab(4); (1)Philipps University Marburg, Marburg, Germany

Rapid Fire: Orthopaedic Biomaterials

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Dental/Orthopaedic Biomaterials
Room: 210/211


Orthopaedic biomaterials may include all kinds of biomaterials for orthopaedic applications (e.g., bone implant/scaffold, 3D printing, drug delivery) and related biological effects. Such biomaterials may include metals, ceramics, polymers, composites, coatings, biodegradables, etc.


  • Implant Degradation / Corrosion

  • 3:15 p.m. 138. Metal-Protein Degradation Products Mediated Neural Cell Defects due to S-phase Arrest, D Bijukumar*, A Segu, Y Mou, X Li, P Chastain, M Mathew; University of Illinois College of Medicine at Rockford, Rockford, IL

  • 3:20 p.m. 139. Direct detection of fluorescently-tagged reactive oxygen species on a cathodically-biased metallic surface, M. Wiegand*, J. Gilbert; Clemson University, Charleston, SC

  • 3:25 p.m. 140. Local and Distant Organ Tissue Responses to Corrosion of Modular Head-Neck Junctions Retrieved Postmortem, D Hall*, R Pourzal, J Wright, S McCarthy, J Jacobs, R Urban; Rush University Medical Center, Chicago, IL

  • 3:30 p.m. 141. In vitro and in vivo studies on biomedical magnesium low-alloying with elements gadolinium and zinc, Y ZHENG*; College of Engineering, Peking University, Beijing, China

  • 3:35 p.m. 142. Development and characterization of metastable beta-Ti alloys for biomedical applications, C Grandini*, P Kuroda, M Lourenço, G Cardoso, B Pedroso, I Rodrigues, K Sousa, T Donato; UNESP - Univ Estadual Paulista, Bauru, Brazil

  • Tissue Engineereing / Scaffolds

  • 3:45 p.m. 143. Fabrication of a Free Radical Scavenging Nanocomposite Scaffold for Bone Tissue Regeneration, K. Dulany*, A. Kelley, J. Allen; University of Florida, Gainesville, FL

  • 3:50 p.m. 144. In Vitro Evaluation of a UV-Cured Gelatin-Nano-Hydroxyapatite Composite System Using MG63 Cells, P. Comeau*, P. Hamilton, S. Mohammadi, M. Gorbet, T. Willett; University of Waterloo, Waterloo, ON

  • 3:55 p.m. 145. Hyaluronic Acid Silica Sol-gel Nano-hybrids by Biomimetic Approach, H. Lee*, Y. Seong, H. Kim; Seoul National University, Seoul, Republic of Korea

  • 4:00 p.m. 146. Cartilage-Mimicking Hydrogels with Abiotic Self-Organizing Nanofiber Network, L Xu*, N Kotov; University of Michigan, Ann Arbor, MI

  • 4:05 p.m. 147. Manipulation of Methacrylated Gelatin Viscosity, UV-Curing Depth and Swelling Behavior by the Controlled Addition of Calcium and Citrate Salts, P. Comeau*, T. Willett; University of Waterloo, Waterloo, ON

  • Device Mechanics and Wear

  • 4:15 p.m. 148. Conformity and Stability in Total Knee Replacements, M. Bebler*, L. Young, N. Meilinger, M. Harman; Clemson University, Clemson, SC

  • 4:20 p.m. 149. In Vitro Wear and Particle Analysis Evaluation of Highly Cross-Linked UHMWPE and Vitamin E UHWMPE Thin Acetabular Liners and its Biological Effects, S Nambu*, G Hines, D Chang; MicroPort Orthopedics, Arlington, TN

  • 4:25 p.m. 150. WITHDRAWN

  • 4:30 p.m. 151. Rolled PCL/GelMA Composites as Scaffolds for ACL Repair, H Kenawy*, M Earley, D Gadalla, A Goldstein; Virginia Tech, Blacksburg, VA

  • 4:35 p.m. 152. Use of Novel Collagen Yarns in a Woven Patch Graft for Rotator Cuff Repair, Y. Xie*(1), O. Akkus(2), E. Cadet(3), M. King(1); (1)North Carolina State University, Raleigh, NC, (2)Case Western Reserve University, Cleveland, OH, (3)Raleigh Orthopaedic Clinic, Raleigh, NC

Rapid Fire: Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering

Timeslot: Wednesday, April 11, 2018 - 3:15pm to 4:45pm
Track: Drug Delivery
Room: Grand Ballroom A


Due to the versatility and diversity of their materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. The bottom-up approach to designing functional objects at the nanoscale has been used to develop individual nanoparticles or to produce highly oriented complexes for a growing number of applications including drug delivery, imaging, theranostics, vaccines, and cancer immunotherapy. In addition, there are exciting opportunities for local therapeutic modulation. This session highlights recent advances in nanomaterials design aimed to enhance the in vivo delivery of therapeutic or imaging payloads for a variety of diseases including those affecting the skin, gastrointestinal and respiratory tracts, cardiovascular system, cancer, and other diseased tissues.


  • 3:15 p.m. 108. Phenylboronic acid-grafted polymer architectures for facile and multifunctional biomolecule delivery into cancer cells, J Kim*(1), W Kim(2); (1)Institute for Basic Science, Pohang, Republic of Korea, (2)POSTECH, Pohang, Republic of Korea

  • 3:20 p.m. 109. Quantitative Supramolecular Drug Loading for Precise Nanomedicine, M. Webber*; University of Notre Dame, Notre Dame, IN

  • 3:25 p.m. 110. Sequential Release of Nanogels from Polymersomes for Dual Intracellular Delivery of Hydrophilic Cargos, F Du*, E Scott; Northwestern University, Evanston, IL

  • 3:30 p.m. 111. Bio-adhesive polymersome for localized and sustained drug delivery at pathological sites with harsh enzymatic and fluidic environment via supramolecular host-guest complexation, M Zhu*, K Wei, S Lin, G Li, L Bian; the Chinese University of Hong Kong, Shatin, Hong Kong

  • 3:35 p.m. 112. Functionalized nanocellulose as stable supports for crystallizing small molecule pharmaceuticals, M Banerjee*, L Willows, B Brettmann; Georgia Institute of Technology, Atlanta, GA

  • 3:45 p.m. 113. CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy, and Photoacoustic Imaging, G. Chen(1), B. Ma(1), Y. Wang(1), R. Xie(1), C. Li(2), K. Dou(3), S. Gong*(1); (1)University of Wisconsin-Madison, Madison, WI, (2)The University of Texas MD Anderson Cancer Center, Houston, TX, (3)Fourth Military Medical University, Xi'an, China

  • 3:50 p.m. 114. Surface Engineered Cerium Oxide Nanoparticles Show Promise for Targeting CD44 Expressing Cancer Cells, M Lord, J Whitelock, K Sutradhar*; University of New South Wales, Sydney, Australia

  • 3:55 p.m. 115. Magnetic Nanoparticle Thermal Treatment Potentiates Paclitaxel Activity in Breast Cancer Cells, A Rivera-Rodriguez*, A Chiu-Lam, V Morozov, A Ishov, C Rinaldi; University of Florida, Gainesville, FL

  • 4:00 p.m. 116. Leukocyte-based biomimetic nanoparticles as a targeted drug delivery vehicle for triple-negative breast cancer, M Sushnitha*(1), J Martinez(2), K Hartman(2), M Evangelopoulos(2), E Tasciotti(2); (1)Rice University, Houston, TX, (2)Houston Methodist Research Institute, Houston, TX

  • 4:05 p.m. 117. Supramolecular Nanotherapeutics for Preferential Immune Modulation of the Tumor Microenvironment, A. Kulkarni*(1), S. Natarajan(2), V. Chandrasekar(2), S. Sengupta(2); (1)University of Massachusetts Amherst, Amherst, MA, (2)Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA

  • 4:15 p.m. 118. Multiplexing antibodies in vivo using Z15_EAK, an Fc-binding gelation module, N. Pham*(1), W. Liu(1), E. Gawalt(1), Y. Fan(2), W. Meng(1); (1)Duquesne University, Pittsburgh, PA, (2)Allegheny-Singer Research Institute, Pittsburgh, PA

  • 4:20 p.m. 119. HER2 – Mediated Targeting of an Intracellular Antibody Delivery System to Breast Cancer Cells, A. Dhankher*, C. Lukianov, J. Champion; Georgia Institute of Technology, Atlanta, GA

  • 4:25 p.m. 120. Development of Bone-Targeted Nanocarriers for Delivery of Gli-Inhibitor to the Bone Microenvironment, J. Vanderburgh*, M. Gupta, S. Wang, A. Merkel, J. Sterling, C. Duvall, S. Guelcher; Vanderbilt University, Nashville, TN

  • 4:30 p.m. 121. Guiding Nanomaterials to Tumors for Breast Cancer Precision Medicine: from Tumor-targeting Small Molecule Discovery to Targeted Nano-drug Delivery, P Qiu*, C Mao; University of Oklahoma, Norman, OK

  • 4:35 p.m. 122. Phage enabled ultrasensitive direct detection of circulating microRNA biomarker in human plasma, Y Zeng*, C Mao; University of Oklahoma, Norman, OK