Biomaterial Technologies for Precision Medicine

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


As the demand for precision medicine continues to rise, the "one size fits all" approach to the design of medical devices and therapies to treating specific diseases and injuries is becoming increasingly outdated. Biomaterials have significant potential for transforming precision medicine, and individual patient complexity often necessitates integrating multiple functions into a single device to successfully tailor personalized therapies. In this session, we seek to highlight the latest research in biomaterials based technologies that enable precision medicine, such as implantable devices for the in situ, real-time analysis of a patient's condition or customized devices or material chemistries that adapt to a specific patient's biology. We aim for our session to demonstrate that biomaterials-based technologies may address limitations to current approaches in precision medicine and may allow for more personalized therapies for patients.


  • 10:30 a.m. 168. Invited Speaker: Natalie Artzi, PhD, Harvard/MIT

  • 11:00 a.m. 169. Injectable, MMP-responsive hydrogels for on-demand siRNA delivery after myocardial infarction, L Wang*, J Chung, S Uman, P Atluri, J Burdick; University of Pennsylvania, Philadelphia, PA

  • 11:15 a.m. 170. Biomaterial scaffolds recruit an aggressive population of metastatic tumor cells in vivo, G. Bushnell*, T. Hardas, R. Hartfield, Y. Zhang, R. Oakes, J. Jeruss, L. Shea; University of Michigan, Ann Arbor, MI

  • 11:30 a.m. 171. Smart Contact Lens for Real-Time Glucose Monitoring and Wirelessly-Controlled Drug Delivery, S Hahn*; POSTECH, Pohang, Republic of Korea

  • 11:45 a.m. 172. Development of a High Throughput 3D Biomaterials Platform to Measure Protease Activity in Breast Cancer Patients, A. Fakhouri*(1), J. Weist(1), A. Tomusko(1), L. Yee(2), J. Leight(1); (1)The Ohio State University, Columbus, OH, (2)City of Hope, Duarte, CA

  • 12:00 noon 173. Magnetically responsive hydrogls for optimizing anticancer therpeutic delivery profiles, T Emi, T Barnes, E Orton, A Reisch, Z Silveira, A Tolouei, S Kennedy*; University of Rhode Island, Kingston, RI

  • 12:15 p.m. 174. The Molecular Signature of a Synthetic Pre-Metastatic Niche for Prediction of Metastatic Potential, R. Oakes*, G. Bushnell, J. Decker, Y. Zhang, R. Hartfield, P. LaFaire, P. Kandagatla, J. Jeruss, L. Shea; University of Michigan, Ann Arbor, MI

Invited Speaker(s)

  • Natalie Artzi, PhD

Biomaterials Tissue Interaction SIG

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


The Biomaterial-Tissue Interaction SIG session will consider abstracts that investigate, in vitro and in vivo, the effects of biomaterial properties, characteristics or modifications on molecular, cellular, and physiological process. These events initiate with specific interactions between biomaterials and biological molecules present in tissues after biomaterial implantation, followed by cell recognition and activation of cellular processes such as cell attachment, proliferation, activation, polarization, differentiation, and necrosis. Understanding these events is the purpose of the Biomaterial-Tissue Interaction (BTI) Special Interest Group.


  • 10:30 a.m. 197. High resolution single-cell correlative microscopy of glial cell interactions with artificial axons, A. Merolli*, Y. Mao, J. Steele, V. Manichev, S. Fung, D. Martin, M. Li, P. Moghe, L. Feldman, T. Gustaffson, C. Dreyfus, J. Kohn; Rutgers - The State University of New Jersey, Piscataway, NJ

  • 10:45 a.m. 198. Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials, D. Zhu*(1), Y. Su(1), Y. Zheng(2), L. Tang(3); (1)University of North Texas, Denton, TX, (2)Peking University, Beijing, China, (3)University of Texas at Arlington, Arlington, TX

  • 11:00 a.m. 199. Foreign Body Response Mitigation and Tissue Integration in Morphologically Unique Bijel-Templated Hydrogel Implants, T Thorson*, E Botvinick, A Mohraz; University of California, Irvine, CA

  • 11:15 a.m. 200. "How You Form it Matters": Processing Techniques of Implant Polymers Differentially Impact Vascular Cell Behavior, K Ammann*, M Li, M Slepian; University of Arizona, Tucson, AZ

  • 11:30 a.m. 201. Immunostimulatory Microgels for Potential Immune Cells Recruitment and Activation, M. Rezaeeyazdi*, T. Colombani, S. Bencherif; Northeastern University, Boston, MA

  • 11:45 a.m. 202. In Vivo Comparison of Polydioxanone and Polyhydroxyalkanoate Barbed Surgical Sutures in a Rat Model, H Cong*(1), G Ruff(2), J Cole(1), D Tokarz(1), S Roe(1), W Liu(3), M King(1); (1)North Carolina State University, Raleigh, NC, (2)Private surgeon, Chapel Hill, NC, (3)Shanghai Ninth People’s Hospital, Jiaotong University School of Medicine, Shanghai, Chin

  • 12:00 noon 203. Influence of surface charge on host response to implanted biomaterials, G. Kokil*, D. Nguyen, A. Dao, T. Dang; Nanyang Technological University, Singapore, Singapore

  • 12:15 p.m. 204. Alternative Foaming Agents for Topical Treatment of Ulcerative Colitis, M. Asama*, A. Hall, Y. Qi, B. Moreau, H. Walthier, M. Schaschwary, B. Bristow, Q. Wang; Iowa State University, Ames, IA

Immune Engineering

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


The Immune Engineering SIG is soliciting abstracts that deal with engineered biomaterials for the development of immunotherapeutics and immune microenvironment engineering, to uncover fundamental mechanisms of immunobiology, and for systems immunology.


  • 10:30 a.m. 205. Ex Vivo Immune Organoids to Model Epigenetics and Transcriptional Feedback Loop in Humoral Immunity, A. Singh*(1), W. Beguelin(2), A. Purwada(1), A. Melnick(2); (1)Cornell University, Ithaca, NY, (2)Weill Cornell Medical College of Cornell University, New You, NY

  • 10:45 a.m. 206. Multi-Niche Human Bone Marrow-on-a-Chip for Studying Hematopoietic Stem Cell Dynamics, M. Nelson*(1), A. Krishnan(2), K. Roy(1); (1)Georgia Institute of Technology and Emory University, Atlanta, GA, (2)Georgia Institute of Technology, Atlanta, GA

  • 11:00 a.m. 207. Biomaterial nanoparticles redistribute therapeutic antibodies to lymph node-resident cells to enhance cancer immunotherapy via checkpoint inhibition, D Francis*, A Schudel, N Rohner, S Thomas; Georgia Institute of Technology, Atlanta, GA

  • 11:15 a.m. 208. Combination Nanovaccine Induces Rapid and Long-lived Protective Immunity against Yersinia pestis, S Kelly*(1), D Wagner-Muniz(1), N Peroutka-Bigus(1), T Dubensky(2), B Bellaire(1), M Wannemuehler(1), B Narasimhan(1); (1)Iowa State University, Ames, IA, (2)Aduro Biotech, Berkeley, CA

  • 11:30 a.m. 209. An antigen-specific microparticle system blocks experimental autoimmune encephalomyelitis, J. Stewart*, J. Cho, T. Drashansky, M. Brusko, A. Zuniga, K. Lorentsen, D. Avram, B. Keselowsky; University of Florida, Gainesville, FL

  • 11:45 a.m. 210. Harnessing Long-Term Release to Produce Robust Long-term Immunity, E Appel*, G Agmon, A Yu; Stanford University, Stanford, CA

  • 12:00 noon 211. Targeted extracellular delivery of Indoleamine 2,3-Dioxygenase via fusion with Galectin 3 ameliorates inflammation in vitro and in vivo, E Bracho-Sanchez*, K Koenders, A Restuccia, M Fettis, M Wallet, F Rocha, S Wallet, G Hudalla, B Keselowsky; University of Florida, Gainesville, FL

  • 12:15 p.m. 212. Characterization of the Immune Response to Biomaterial-Mediated Infection Following Trauma, C. Vantucci*(1), H. Ahn(2), M. Schenker(2), P. Pradhan(1), K. Roy(1), R. Guldberg(1), N. Willett(2); (1)Georgia Institute of Technology, Atlanta, GA, (2)Emory University, Atlanta, GA

Nano Drug Delivery

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Drug Delivery
Room: Grand Ballroom D


The Drug Delivery SIG session will consider abstracts that fall with the broad areas of therapeutic development, formulation, and application testing. Drug delivery from medical devices, tissue engineering scaffolds/hydrogels, films, microparticles, nanoparticles, environmentally responsive materials, and other types of biomaterial assemblies are all invited. Studies testing drug targeting, drug combinations, and drug/cell combinations are all also welcomed to submit. Drug delivery application areas of interest include but are not limited to regenerative medicine/tissue engineering, cell and tissue transplant, cardiovascular stents and other devices, cancer, microbial infection, and autoimmune diseases.


  • 10:30 a.m. 182. S-nitrosated poly(propylene sulfide) nanoparticles for enhanced nitric oxide delivery to lymphatic tissues and lymph node-resident cells, A Schudel*, L Sestito, S Thomas; Georgia Institute of Technology, Atlanta, GA

  • 10:45 a.m. 183. Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery, E Appel*, C Maikawa, G Agmon; Stanford University, Stanford, CA

  • 11:00 a.m. 184. Galectin-8 Imaging Demonstrates Endosomal Disruption by Nanocarrier and Predicts Biologic Drug Intracellular Bioavailability, K. Kilchrist*, S. Dimobi, T. Werfel, E. Dailing, M. Jackson, C. Duvall; Vanderbilt University, Nashville, TN

  • 11:15 a.m. 185. Efficient Gene Editing Using a Bioegradable Nanocapsule Containing Cas9 Ribonucleoprotein, A. Abdeen*, G. Chen, P. Shahi, R. Xie, B. Pattnaik, S. Gong, K. Saha; University of Wisconsin-Madison, Madison, WI

  • 11:30 a.m. 186. Optimization and comparison of CD4-targeting lipid-polymer hybrid nanoparticles using different binding ligands, S. Cao*(1), Y. Jiang(1), C. Levy(1), S. Hughes(1), H. Zhang(1), F. Hladik(2); (1)University of Washington, Seattle, WA, (2)Fred Hutchinson Cancer Research Center, and University of Washington, Seattle, WA

  • 11:45 a.m. 187. Engineered Extracellular Vesicles with Synthetic Lipids via Membrane Fusion to Establish Efficient and Targeted Drug and Gene Delivery, Y. Jhan*, D. Moore, S. Arun Kumar, C. Bishop; Texas A&M University, College Station, TX

  • 12:00 noon 188. Development of Layer-by-Layer Assembled Nanoshells for Intracellular miR-34a Delivery, R. Goyal, E. Day*; University of Delaware, Newark, DE

  • 12:15 p.m. 189. NIR Triggered Photodynamic/Chemotherapy in Combination with Immunotherapy by Using Cascade Upconversion Nanoparticles for Elimination of Primary Tumor and Remission of Metastasis, J. Chen*; Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China

Panel: Career Catalysis: Strategies for Biomaterials Education and Professional Development

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Career and Commercialization
Room: Grand Ballroom B


This panel discussion will provide young investigators with tools and best practices for securing research funding from internal, federal, and industrial sources. The workshop will highlight various funding opportunities for different academic levels, granstmanship, and strategies for incorporating educational components into research proposals. Program officers from federal agencies, such as NSF and NIH, will provide guidelines for various grant opportunities. Academic faculty with successful awards will also provide helpful tips and tricks. Attendees will also have the opportunity to bring drafts of proposals for review and revision by workshop leaders.

Invited Speaker(s)

  • Rosemarie Wesson, PhD
  • Delphine Dean, PhD
  • Anirban Sen Gupta, PhD

Racing for the Surface: Recent Development in Antimicrobial and Osteoinductive Biomaterials

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Dental/Orthopaedic Biomaterials
Room: 206/207


It is well known that bacteria and host cells race for the surfaces of implants. This symposium will cover topics related to antimicrobial biomaterials (e.g., antibiotics, antimicrobial peptides, vaccines, immunotherapeutic approaches, etc.), antimicrobial coatings, antimicrobial delivery vehicles, and osteoconductive and osteoinductive biomaterials (e.g., hydroxyapatite, BMP, etc.), as well as research integrating both antimicrobial and osteoinductive/osteoconductive properties. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance will also be sought. It is expected that the past, present, and future of antimicrobial and osteoinductive biomaterials will be presented by well-respected researchers in the fields.


  • 10:30 a.m. 190. Invited Speaker: Andres Garcia, PhD, Georgia Tech

  • 11:00 a.m. 191. In vitro competition of oral mammalian cells and early oral colonizers on titanium substrates, W. Huo*, K. Palmer, S. Wheelis, D. Rodrigues; University of Texas at Dallas, richardson, TX

  • 11:15 a.m. 192. Antimicrobial Activities of Conventional and Novel Antimicrobial Agents against S. aureus Biofilms, J. Kang*(1), B. Li(2); (1)West Virginia University, Morgantown, WV, (2)West Virginia University School of Medicine, Morgantown, WV

  • 11:30 a.m. 193. Nanosilver Dopped Nanosilica and RGD Mimetic Hydrogel Repairing Infected Bone Defect, M Xing*; University of Manitoba, Winnipeg, MB

  • 11:45 a.m. 194. Nanopatterning of bacterial nanocellulose and polydimethylsiloxane for anti-biofouling polymeric interfaces, S Arias*, J Devorkin, M Cheng, C Jaramillo, A Civantos, J Allain; University of Illinois at Urbana-Champaign, urbana, IL

  • 12:00 noon 195. Evaluation of Two Different Neutralization Methods for Chitosan Coatings, K. Patel*, J. Bumgardner; The University of Memphis, Memphis, TN

  • 12:15 p.m. 196. Enhancing Design of Anti-Biofilm Drug Delivery Nanoparticles via High Throughput Screening, K Sims*(1), Y Liu(2), P Dunman(1), H Koo(2), D Benoit(1); (1)University of Rochester, Rochester, NY, (2)University of Pennsylvania, Philadelphia, PA

Invited Speaker(s)

  • Andres J. Garcia, PhD, FBSE

The Convergence of Advanced Materials with Developmental Biology

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Tissue Engineering
Room: Grand Ballroom C


Regenerative Engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and clinical translation to develop innovative, scalable tools to regenerate damaged or diseased complex tissues and organs. This symposium will include presentations that describe how biomaterials inspired from the fields of nanotechnology, cell and molecular biology, and medicine can improve health. The session will cover how clinical translation may/should drive biomaterial design by fostering discussion among clinician/scientists, engineers, and representatives from companies with interest in tissue engineering and regenerative medicine.


  • 10:30 a.m. 175. Invited Speaker: Jennifer West, PhD, Duke University

  • 11:00 a.m. 176. Nonviral Direct Conversion of Fibroblasts to Neuronal Cells Using Polydopamine-coated Nanofibril scaffold, H Kim*(1), H Kim(2), K Leong(1); (1)Columbia University, New York, NY, (2)Dankook University, Cheonan, Republic of Korea

  • 11:15 a.m. 177. Controlling Osteogenic Differentiation of hMSCs Encapsulated in Thiol-Epoxy Crosslinked PEG-based Hydrogels, C Huynh*(1), F Liu(1), Y Cheng(1), K Coughlin(2), E Alsberg(1); (1)Case Western Reserve University, Cleveland, OH, (2)Northwestern University, Evanston, IL

  • 11:30 a.m. 178. Biomedical Applications of Magnetic Nanoparticles for Regenerative Medicine, J Dobson*; University of Florida, Gainesville, FL

  • 12:00 noon 179. Tissue Origami for Regenerative Engineering, G. Camci-Unal*; University of Massachusetts Lowell, Lowell, MA

  • 11:45 a.m. 180. Dynamic transcription factor activity networks in response to ovarian follicle culture environments, H. Zhou*, J. Decker, C. Tomaszewski, L. Shea, A. Shikanov; University of Michigan, Ann Arbor, MI

  • 12:15 p.m. 181. Tunable synthetic PEG hydrogels for supporting lymphangion sprouting lymphangiogenesis, J Hooks*, R Cruz-Acuña, A García, J Dixon; Georgia Institute of Technology, Atlanta, GA

Invited Speaker(s)

  • Jennifer West, PhD

Thought Leader: Leonard Pinchuk

Timeslot: Thursday, April 12, 2018 - 10:30am to 12:30pm
Track: Thought Leaders/Ethics
Room: Grand Ballroom A


The Innovation Processes from Industry and Academia


  • This panel consists of three entrepreneurial inventors who were successful in bringing products from concept to market. Dr. Pinchuk will present the "Three-Legged Stool of Innovation" which dives into the thought processes that drive innovation. He will review his 30 year industrial experience developing new products in cardiology and ophthalmology and explain how they fit the three-legged stool model. Dr. Paul Santerre will view the entrepreneurial process with an academic lens and describe from his 25 years of translational experience with innovation and discovery, how "the processes that drive innovation" can be accommodated within an academic environment, using a team approach which emphasizes identifying strategic roles for faculty and trainees in that process. That experience has led to the formation of several start-ups and technology translational activities in the cardiovascular, tissue regeneration and musculoskeletal areas from his lab, and more recently in 2015 the establishment of the Health Innovation Hub at the University of Toronto, Canada - a student-focused entrepreneurial training co-curricular program with > 70 client health science and biomedical engineering start-ups to date. Dr. Michele Marcolongo has co-founded several companies which originated from work performed at Drexel University. She has recently authored a book titled Academic Entrepreneurship: How to Bring your Scientific Discovery to a Successful Commercial Product. Dr. Marcolongo will discuss the steps associated with translating a technology from the lab, through the labyrinth of the university and to a commercialized effort with a focus on the internal conflict that accompanies the process.