*BTI* From Conception to Clinical Trial: Examples of Technology Development

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Career and Commercialization
Room: Grand Ballroom B


The session seeks to illustrate the entire development cycle of biomaterials-based technologies from conception to the clinic. The aim is to give the audience perspective on the development process through specific examples with supporting data. Presenters from industry and academia/healthcare settings are welcome. Talks may be of extended duration (20 mins) and could be presented by a single speaker or two speakers (a scientist/engineer and a clinician to separately present the pre-clinical and clinical outcomes).


  • 1:45 p.m. 213. Invited Speaker: Jeff Karp, PhD, Brigham and Women's Hospital, Harvard Medical School

  • 2:15 p.m. 214. Invited Speaker: David Kaplan, PhD, Tufts University

  • 2:45 p.m. 215. Development of a Sprayable Biopolymer Hydrogel for the Prevention of Postoperative Adhesions, L Costella*(1), M Patterson(1), B Janet(1), P Cottler(2), C Tison(1); (1)Luna Innovations, Charlottesville, VA, (2)University of Virginia, Charlottesville, VA

  • 3:00 p.m. 216. Translation of a Crosslinked Hyaluronic Acid Gel for Corneal Repair from the Bench to Veterinary and Human Medicine, B. Mann*(1), S. Atzet(2), B. Wirostko(1); (1)EyeGate Pharmaceuticals, Salt Lake City, UT, (2)SentrX Animal Care, Salt Lake City, UT

  • 3:15 p.m. 217. 3D bioprinting personalized neural tissues for drug screening applications, M. Robinson(1), L. Abelseth(1), S. Singh(1), C. Blood(1), S. Wadsworth*(2), S. Willerth(1); (1)University of Victoria, Victoria, BC, (2)Aspect Biosystems, Vancouver, BC

  • 3:30 p.m. 218. High throughput solution deposited hydroxyapatite coatings for orthopedic implants, C. Ernsberger, S. Vass, B. Smith, J. Langhorn, H. Qu, D. Ettensohn, R. Kasinath*; DePuy Synthes Joint Reconstruction, Warsaw, IN

Invited Speaker(s)

  • Jeff Karp, PhD
  • David Kaplan, PhD

Biomaterial Technologies for Hemostatis and Wound Care

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


Stopping bleeding (hemostasis) and providing short and long-term wound care via passive and/or bioactive mechanisms is an important area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in hemostatic biomaterials and to facilitate discussion of best practices for moving hemostatic technologies from the benchtop to the clinic. The proposed session will invite presentations from researchers in this field that discuss biomaterials design, structure-property-function relationships, and achieved/ongoing/future visions of technology translation pathways. An emphasis will be placed on translational aspects of hemostatic technologies.


  • 1:45 p.m. 239. Invited Speaker: Kenton Gregory, PhD, Oregon Health & Science University

  • 2:15 p.m. 240. SynthoPlate: An Intravenous Synthetic Hemostat for Pre-hospital Treatment of Traumatic Hemorrhage, C Pawlowski*(1), D Hickman(1), N Luc(1), M Dyer(2), A Shevitz(3), A Kim(3), M Neal(2), V Kashyap(3), A Sen Gupta(1); (1)Case Western Reserve University, Cleveland, OH, (2)University of Pittsburgh Medical Center, Pittsburgh, PA, (3)University Hospitals, Cl

  • 2:30 p.m. 241. Supplementing Coagulation Factor XIIIa and a Synthetic Polymeric Substrate of Factor XIIIa Recovers Clot Adhesion of Fibrin-Poor Blood, K. Chan*, C. Zhao, E. Siren, J. Chan, J. Boschman, J. Yeon, C. Kastrup; University of British Columbia, Vancouver, BC

  • 2:45 p.m. 242. Wound targeting fibrinolytic nanogels for treating disruptive widespread clot activation, E. Mihalko*, N. Mininni, A. Brown; North Carolina State University, Raleigh, NC

  • 3:00 p.m. 243. Laser-Activated Tissue Integrating Sutures (LATIS) for Rapid Wound Closure, D. Ghosh*, R. Urie, J. Kilbourne, J. Lee, K. Rege; Arizona State University, Tempe, AZ

  • 3:15 p.m. 244. Adipose Derived Stem Cells Combined with an Advanced Collagen Wound Matrix for Treatment of Chronic, Non-Healing Diabetic Skin Wounds, N. Edwards*(1), W. Friedrichs(2), D. Feliers(2), R. Christy(3), R. Stone(3), Q. Zhao(3), X. Cheng(4); (1)University of Texas at San Antonio, San Antonio, TX, (2)University of Texas Health San Antonio, San Antonio, TX, (3)US Army Institute of Surgical Rese

  • 3:30 p.m. 245. Silk Nanosealants for Laser-Activated Tissue Repair, R Urie*, D Ghosh, C Guo, J Kilbourne, J Lee, J Yarger, K Rege; Arizona State University, Tempe, AZ

Invited Speaker(s)

  • Kenton Gregory, PhD

Implantable Bioelectronics

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Biomaterials Applications
Room: 204/205


Bioelectronics, electronics designed to interface with biology, are an important class of biomaterials that are gaining significant interest. Clinical successes in implantable bioelectronics include pacemakers, blood glucose monitoring, and recording and stimulating neural probes, but these still face issues of longterm biocompatibility and device function. There have also been great advances in the next generation of intracorporeal bioelectronics which are small, soft, flexible, bioresorbable and biocompatible and which have applications ranging from electrophysiology, manipulating cell behavior and tissue growth, biosensing, drug delivery and optogenetics. The focus of this session will be on what the field can learn from existing implantable platforms and what are their remaining challenges as well as what exciting new in vivo bioelectronic technologies are on the horizon.


  • 1:45 p.m. 232. Invited Speaker: Stephanie Lacour, PhD, École Polytechnique Fédérale de Lausanne

  • 2:15 p.m. 233. Biodegradable piezoelectric force sensor for monitoring biological pressures, T Nguyen*; University of Connecticut, Storrs, CT

  • 2:30 p.m. 234. Plug-and-Play Mesh Electronics with Nanowire Field-Effect Transistor Sensors for In Vivo Bio-Nano Interfacing, T. Schuhmann*, J. Yao, G. Hong, T. Fu, C. Lieber; Harvard University, Cambridge, MA

  • 2:45 p.m. 235. Silk-Inspired Neurotechnology: Soft, Flexible and Conformal Silk Electrode Interfaces for The Peripheral Nerve, A Patil*, N Thakor; National University of Singapore, Singapore, Singapore

  • 3:00 p.m. 236. In Situ Polymerized Neural Interfaces for Peripheral Nerve Recording and Stimulation, J. Murbach*(1), Y. Tong(2), V. Subramanian(3), S. Chhatre(3), B. Johnson(2), D. Martin(3), K. Otto(1); (1)University of Florida, Gainesville, FL, (2)Virginia Tech, Blacksburg, VA, (3)University of Delaware, Newark, DE

  • 3:15 p.m. 237. Neural Interfacing with a Microfluidic Ion Pump, C. Proctor*(1), A. Slezia(2), A. Williamson(2), G. Malliaras(1); (1)University of Cambridge, Cambridge, United Kingdom, (2)Aix-Marseille University, Marseille, France

  • 3:30 p.m. 238. Melatonin Injection Improves Quality and Longevity of Chronic Neural Recording, A. Golabchi*(1), B. Wu(1), T. Kozai(1), X. Cui(1); University of Pittsburgh, Pittsburgh, PA

Invited Speaker(s)

  • Stephanie P. Lacour, PhD

Intelligent Hydrogels for Biomedical Applications (joint symposium with Korean Society for Biomaterials)

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Biomaterials Fabrication and Analysis
Room: Grand Ballroom C


Intelligent hydrogels have immense significance for a wide range of biomedical applications. For example, injectable and biodegradable hydrogels have shown great promise not only as space filling materials by themselves, but also as noninvasive carriers for delivery of bioactive molecules or therapeutic cell sources. Furthermore, polymers with shear thinning properties have been combined with 3D printing techniques, which are advanced to print a 3D structure with living cells (so called bioprinting), demonstrating great potential to build functional tissues for the replacement of damaged organs. In addition, the hydrogels have been delicately designed to modulate a specific niche environment for stem cells, which are now used for improved cell therapy and personalized diagnostics. This symposium is aimed to overview state of art research on the synthesis and characterization of intelligent hydrogel systems, and their applications on drug delivery and tissue engineering. This symposium is coorganized by the Korean Society for Biomaterials that will host the World Biomaterials Congress (WBC) 2024. This annual symposium will become a bridge for a long term relationship and mutual benefits for both Society members by promoting cooperation, collaboration, and networking.


  • 1:45 p.m. 219. Invited Speaker: Hydrogen peroxide-controllable hydrogels for vascular tissue regeneration, Y Lee(1), J Son(1), J Kang(2), K Park(2), K Park*(1); (1)Ajou University, Suwon, Republic of Korea, (2)Incheon National University, Incheon, Republic of Korea

  • 2:15 p.m. 220. Invited Speaker: Jason Burdick, University of Pennsylvania

  • 2:45 p.m. 221. Covalently Tethering Transfection-Capable siRNA to Hydrogels for Sustained Release and Gene Silencing, C Huynh*(1), M Nguyen(1), A Gilewski(1), S Wilner(2), K Maier(2), N Kwon(1), M Levy(2), E Alsberg(1); (1)Case Western Reserve Univercity, Cleveland, OH, (2)Albert Einstein College of Medicine, Bronx, NY

  • 3:00 p.m. 222. Spatiotemporal control over intestinal organoid formation in photodegradable hydrogels, T. Brown*(1), N. Gjorevski(2), M. Lutolf(2), K. Anseth(1); (1)University of Colorado - Boulder, Boulder, CO, (2)Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland

  • 3:15 p.m. 223. Self-folding of multi-layered hydrogel designed for biological machine, S Cho*, S Shin, H Kim, S Han, J Jeong; Soongsil University, Seoul, Republic of Korea

  • 3:30 p.m. 224. Molecular Modeling to Predict Peptide Accessibility for Peptide-Functionalized Hydrogels, X. Li, J. Jia, Y. Mei, R. Latour*; Clemson University, Clemson, SC

Invited Speaker(s)

  • Ki Dong Park, PhD
  • Jason Burdick, PhD

Next Generation Biomaterials for Islet Delivery and Immune Acceptance for Diabetes

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


Type 1 diabetes is an autoimmune disease in which the insulin-producing beta cells of the pancreas are destroyed. Transplantation of pancreatic islet cells isolated from donors has emerged as a promising strategy for the treatment of type 1 diabetes. However, this strategy is severely limited by islet loss due to inflammation, inadequate blood supply, and immune rejection. Biomaterial technologies are absolutely critical to the successful widespread application of islet transplantation in humans. This symposium will focus on novel biomaterials and technologies to improve islet survival and function. Examples include (i) new immune-directing encapsulating polymers, (ii) materials delivering immunomodulatory agents, and (iii) biomaterials addressing hypoxia, inflammation, and vascularization.


  • 1:45 p.m. 246. Invited Speaker: Cherie Stabler, PhD, University of Florida

  • 2:15 p.m. 247. Design of degradable PEG hydrogels to deliver CCL21 and ? cell autoantigens for the induction of peripheral tolerance in type 1 diabetes, S Zustiak(1), A Tomei(2), D Velluto(2), M Abreu(2), A Stock*(2); (1)Saint Louis University, Saint Louis, MO, (2)University of Miami, Miami, FL

  • 2:30 p.m. 248. The timing is crucial for adequate blood perfusion of an artificial subcutaneous site for pancreatic islet transplantation, A. Patikova*, L. Kosinova, A. Vojtiskova, E. Sticova, J. Kriz; Institute for Clinical and Experimental Medicine, Prague, Czech Republic

  • 2:45 p.m. 249. Enzymatic peptide ligation for in situ encapsulation and delivery of pancreatic islets, M Arkenberg*, C Lin; Indiana University Purdue University Indianapolis, Lebanon, IN

  • 3:00 p.m. 250. Clinically Translatable Immunomodulatory Cytokine Eluting Alginate Microbeads containing Neonatal Porcine Islet-like Clusters for the Treatment of Type 1 Diabetes, P Varde*(1), J Hutcheson(1), K Buac(1), J Cano(1), B Denney(1), K Grooms(1), C Seawell(1), R Rodriguez(1), M Poznansky(2), S McCormack(1), S Chavan(1); (1)ViCapsys Inc., Athens, GA, (2)The Vaccine and Immunotherapy Center, Massachusetts General Hospital,

  • 3:15 p.m. 251. Subcutaneous transplantation of reconstituted pseudo-islets to restore normoglycemia in diabetic SCID/bg mice, A Vlahos*, S Keshavjee, S Kinney, A Martyts, M Sefton; University of Toronto, Toronto, ON

  • 3:30 p.m. 252. Microfluidic Poly(ethylene glycol)-based Islet Encapsulation Enables Transplantation in Highly Vascularized Site, J Weaver*, D Headen, M Coronel, M Hunckler, A Garcia; Georgia Institute of Technology, Atlanta, GA

Invited Speaker(s)

  • Cherie Stabler, PhD

Panel: Dental/Craniofacial Arena: Opportunities, Regulations and Minefields in the Pathway from Benchtop to Commercialization

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Dental/Orthopaedic Biomaterials
Room: 206/207


Presenters will offer insight into the dynamic and innovative field of dental/maxillofacial technology where cutting-edge imaging technology and additive manufacturing technology meet reconstructive biomaterials. To launch these products to the clinical professional requires knowledge in financing/funding, clinical practices, regulations and business/marketing acumen. Dental/maxillofacial technologies tend to be disruptive. What are the forces that influence which product is a winner and which is a loser? Where can we expect to see grant awards, regulatory changes and new market trends? Are there ways to use cutting edge technology to bring down the costs of reconstructive dental and maxillofacial products as the population ages and purchasing power is reduced?

Invited Speaker(s)

  • Christopher J. Damien, PhD
  • Sherrill Lathrop Macura, PhD
  • Ahmed El-Ghannam, PhD
  • Joel Anderson, PhD
  • Paulo G. Coelho, PhD

The Preclinical and Clinical Experience with Regenerative Biomaterials

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Tissue Engineering
Room: Grand Ballroom D


Regenerative Engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and clinical translation to develop innovative, scalable tools to regenerate damaged or diseased complex tissues and organs. This symposium will include presentations that describe how biomaterials inspired from the fields of nanotechnology, cell and molecular biology, and medicine can improve health. The session will cover how clinical translation may/should drive biomaterial design by fostering discussion among clinician/scientists, engineers, and representatives from companies with interest in tissue engineering and regenerative medicine.


  • 1:45 p.m. 225. Invited Speaker: Treena Arinzeh, PhD, NJIT

  • 2:15 p.m. 226. Degradable, “Self-fitting” Shape Memory Polymer (SMP) Scaffolds for Cranial Bone Defect Repair, M Grunlan*, L Woodard, A Roth, K Kmetz, V Page; Texas A&M University, College Station, TX

  • 2:30 p.m. 227. Stem Cell Seeded Biomimetic Nucleus Pulposus and Annulus Fibrosus Implants Promote Living Repair of Degenerative Intervertebral Discs in Sheep, R. Borem*(1), J. Walters(1), A. Madeline(1), L. Madeline(2), S. Gill(3), J. Mercuri(1); (1)Clemson University, Clemson, SC, (2)Greenville Health System, Greenville, SC, (3)Medical Group of the Carolinas, Greer, SC

  • 2:45 p.m. 228. A Thermoresponsive, Citrate-based Macromolecule for Bone Regenerative Engineering, S. Morochnik(1), Y. Zhu(1), C. Duan(1), M. Cai(1), R. Reid(2), T. He(2), J. Koh(2), I. Szleifer(1), G. Ameer*(1); (1)Northwestern University, Evanston, IL, (2)University of Chicago, Chicago, IL

  • 3:00 p.m. 229. Tetrazine Click-Mediated Functionalization and Assembly of Microgel-Based Scaffolds for Tissue Engineering, F. Jivan*, D. Alge; Texas A&M University, College Station, TX

  • 3:15 p.m. 230. Bio-inspired design of a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes, M. Ma*; Cornell University, Ithaca, NY

  • 3:30 p.m. 231. Decellularized extracellular matrix microparticles seeded with bone marrow mesenchymal stromal cells for treatment of full-thickness cutaneous wounds, A. Westman*(1), R. Goldstein(1), G. Bradica(2), S. Goldman(2), M. Randolph(1), J. Gaut(3), J. Vacanti(1), D. Hoganson(4); (1)Massachusetts General Hospital, Boston, MA, (2)DSM Biomedical, Exton, PA, (3)Washington University in St. Louis, St. Louis, MO, (4

Invited Speaker(s)

  • Treena Arinzeh, PhD

Thought Leader: Anti-cancer therapies (David Mooney)

Timeslot: Thursday, April 12, 2018 - 1:45pm to 3:45pm
Track: Thought Leaders/Ethics
Room: Grand Ballroom A


This symposium will explore the development of new anti-cancer therapies, transitioning from the molecular to cellular and tissue level analysis and design of biomaterial-based strategies.


  • Cheng Zhu (Georgia Tech): Molecular analysis and design for cancer therapies

  • Claudia Fischbach (Cornell): 3D in vitro cancer models

  • Leaf Huang (UNC): Nanoparticle-based cancer therapies

  • David Mooney (Harvard): Building immunity with biomaterials

Invited Speaker(s)

  • Cheng Zhu, PhD
  • Claudia Fischbach-Teschl, PhD
  • Leaf Huang, PhD
  • David Mooney, PhD