*BTI* Testing Methods for Evaluating Translational Biomaterials

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Career and Commercialization
Room: Grand Ballroom B


  • 4:15 p.m. 253. Physiochemical Characterization and Biocompatibility of Ionic Dimethacrylates for Dental Restorations, D. Bienek*(1), S. Frukhtbeyn(1), U. Okeke(1), A. Giuseppetti(1), R. Pires(2), J. Antonucci(3), D. Skrtic(1); (1)ADA Foundation, Gaithersburg, MD, (2)Montgomery College, Germantown, MD, (3)National Institute for Standards and Technology, Gaithersburg, MD

  • 4:30 p.m. 254. Multiscale Tuning and Classification of Biological Cell Confinement in Fibrous Microenvironments, F. Tourlomousis*(1), C. Jia(2), H. Wang(2), D. Kalyon(3), R. Chang(4); (1)Massachusetts Institute of Technolology, Cambridge, MA, (2)Biomedical Engineering Department, Stevens Institute of Technology, , , (3)Chemical Engineering & Materials Science Depart

  • 4:45 p.m. 255. Sarcomeric Addition in an Aligned Myocyte Culture Model Visualized by SHG Confocal Microscopy, Z. Wang(1), A. Wei*(1), X. Yang(1), S. Ma(1), B. Thomas(2), B. Gao(1); (1)Clemson, Clemson, SC, (2)Medical University of South Carolina, Charleston, SC

  • 5:00 p.m. 256. Application of Electrochemical Sensors to Study Dental Composites, D. Koley*(1), G. Ummadi(1), S. Aponso(1), H. Davis(2), J. Ferracane(2); (1)Oregon State University, Corvallis, OR, (2)Oregon Health & Science University, Portland, OR

  • 5:15 p.m. 257. Novel testing methodology for chemical durability of ceramics used in the oral cavity, J Esquivel-Upshaw*(1), F Ren(2), S Hsu(1), F Dieng(1), D Neal(1), A Clark(2); (1)University of Florida College of Dentistry, Gainesville, FL, (2)University of Florida College of Engineering, Gainesville, FL

  • 5:30 p.m. 258. Using simultaneous measurements during photopolymerization to measure relaxation time growth and connection to network clustering, S. Sarkar*, S. Lin-Gibson, M. Chiang; National Institute of Standards and Technology, Gaithersburg, MD

  • 5:45 p.m. 259. Biocompatibility and Suitability of FDM Additive Manufacturing Filaments for use in Tissue Engineering Scaffolds, M. Taylor*, B. Gaerke, B. Johns; Poly-Med, Inc., Anderson, SC

  • 6:00 p.m. 260. NON DESTRUCTIVE MONITORING OF 3D CULTURES OF MSC BASED ON SHIFTING METABOLISM, V. Sikavitsas*, A. Simmons; The University of Oklahoma, Norman, OK

Biomaterials and Scaffolds for Interfacial Tissue Engineering

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Tissue Engineering
Room: Grand Ballroom C


Musculoskeletal tissue interfaces are complex, heterogeneous tissues in which the specific spatial composition is tightly linked to biological function. Biomaterials for interfacial tissue engineering must therefore be designed to guide biomimetic tissue organization to regenerate functional constructs. This session will focus on novel biomaterials-based strategies to regenerate musculoskeletal interfaces with particular attention to approaches to control the spatial organization of chemical and/or physical cues to direct cell and tissue response locally and globally within a scaffold. These include advanced scaffold fabrication, biochemical functionalization, scaffold-cell interactions, physical and structural cues, spatial growth factor control, and stem cell lineage commitment for musculoskeletal tissue interface regeneration.


  • 4:15 p.m. 268. Invited Speaker: Helen Lu, PhD, Columbia University

  • 4:45 p.m. 269. Spatiotemporally controlled transgene expression in hydroxyapatite-doped fibrin scaffolds using high intensity focused ultrasound, A. Moncion(1), J. Harmon(1), Y. Li(1), O. Kripfgans(1), J. Stegemann(1), F. Martín-Saavedra(2), N. Vilaboa(2), R. Franceschi(1), M. Fabiilli*(1); (1)University of Michigan, Ann Arbor, MI, (2)Hospital Universitario La Paz-IdiPAZ, Madrid, Spain

  • 5:00 p.m. 270. Direct Fabrication of Cell-Loaded Nanofibrous Hydrogel Scaffolds Using Reactive Electrospinning, F. Xu*, M. Dodd, H. Sheardown, T. Hoare; McMaster University, Hamilton, ON

  • 5:15 p.m. 271. A Continuous Pore Size Gradient PLLA Scaffold for Osteochondral Regeneration Tested in a Biphasic Bioreactor, R. Gottardi*(1), G. Conoscenti(2), P. Alexander(1), V. La Carrubba(2), V. Brucato(2), R. Tuan(1); (1)University of Pittsburgh, Pittsburgh, PA, (2)Universita` degli Studi di Palermo, Palermo, Italy

  • 5:30 p.m. 272. Dynamic biointerfaces based on sulfonated polyrotaxanes for enhancing osteogenic differentiation, Y. Arisaka*, N. Yui; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan

  • 5:45 p.m. 273. Manufacturing Gradient Fibers using Magnetically-Assisted Electrospinning for Interfacial Tissue Engineering, R. Tindell, M. Le, A. Gualtieri, J. Holloway*; Arizona State University, Tempe, AZ

  • 6:00 p.m. 274. Triphasic biomaterial for enhanced toughness and regeneration of the osteotendinous junction, R Sun Han Chang*, C Lee, S Rogers, B Harley; University of Illinois at Urbana–Champaign, Urbana, IL

Invited Speaker(s)

  • Helen Lu, PhD

Engineering Cells and Their Microenvironments

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


The Engineering Cells & Their Microenvironments Special Interest Group concentrates on technologies and approaches focused at the single cell level and encompassing engineering cell microenvironments, biomaterial-induced cell signaling, stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis.


  • 4:15 p.m. 290. Recapitulating Physical Changes in the Extracellular Matrix with Dynamic Hydrogels, A. Rosales*(1), S. Vega(2), F. DelRio(3), J. Burdick(2), K. Anseth(4); (1)The University of Texas at Austin, Austin, TX, (2)University of Pennsylvania, Philadelphia, PA, (3)National Institute of Standards and Technology, Boulder, CO, (4)University of Colo

  • 4:30 p.m. 291. Fabrication of a Vascularized Tumor Microenvironment for Immunotherapy, M Dey*(1), E Karhan(2), C Tastan(2), D Unutmaz(2), I Ozbolat(1); (1)Pennsylvania State University, State College, PA, (2)Jackson Laboratory for Genomic Medicine, Farmington, CT

  • 4:45 p.m. 292. A MMP7-sensitive photoclickable biomimetic hydrogel for MSC encapsulation and engineering human cartilage, E Aisenbrey*, S Bryant; University of Colorado, Boulder, CO

  • 5:00 p.m. 293. Dynamics of autocrine and paracrine domains in hematopoietic stem cell culture, A. Gilchrist*(1), B. Mahadik(2), S. Lee(1), Y. Hu(1), B. Harley(1); (1)University of Illinois at Urbana-Champaign, Urbana, IL, (2)National Institute of Health, Urbana, IL

  • 5:15 p.m. 294. Measuring Three-Dimensional Shape of Bone Marrow Stromal Cells Cultured in Tissue Engineering Scaffolds, C. Simon*, M. Simon, D. Juba, P. Pine, S. Sarkar, D. Chen, P. Baker, S. Bodhak, A. Cardone, M. Brady, P. Bajcsy, B. Pazmino, J. Douglas, W. Keyrouz, C. Lee, S. Florczyk; NIST, Gaithersburg, MD

  • 5:30 p.m. 295. Riboflavin as a visible light photoinitiator for dynamic stiffening of cell-laden hydrogels, H Nguyen*(1), H Liu(2), C Lin(1); (1)Indiana University Purdue University Indianapolis, Indianapolis, IN, (2)Purdue University, West Lafayette, IN

  • 5:45 p.m. 296. Oxygenating microparticles for localized oxygenation to 3D tissue environments, P Patil*, N Leipzig; The University of Akron, akron, OH

  • 6:00 p.m. 297. Anticancer Efficacy of Tannic Acid is Dependent on the Stiffness of the Underlying Matrix, C. Bridgeman, T. Nguyen, V. Kishore*; Florida Institute of Technology, Melbourne, FL

Orthopaedic Biomaterials SIG

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Dental/Orthopaedic Biomaterials
Room: 206/207


Orthopaedic biomaterials may include all kinds of biomaterials for orthopaedic applications (e.g., bone implant/scaffold, 3D printing, drug delivery) and related biological effects. Such biomaterials may include metals, ceramics, polymers, composites, coatings, biodegradables, etc.


  • 4:15 p.m. 283. Invited Speaker: Jian Yang, PhD, The Pennsylvania State University

  • 4:45 p.m. 284. Perfusion Driven 3D Bone Mineral Formation, S Sawyer*(1), S Shridhar(1), K Zhang(1), L Albrecht(1), J Horton(2), P Soman(1); (1)Syracuse University, Syracuse, NY, (2)SUNY Upstate Medical University, Syracuse, NY

  • 5:00 p.m. 285. Assessing if Bone Ingrowth is affected by Silicone as a Carrier to Deliver Antimicrobials for the Treatment of Periprosthetic Infections, N Taylor*, R Epperson, B Kawaguchi, D Williams; Department of Veterans Affairs, Salt Lake City, UT

  • 5:15 p.m. 286. Silk Fibroin/Elastin Bioinks for 3D Printing of Implants Respecting the Patient Intervertebral Disc Anatomy, J. Costa, J. Silva-Correia*, V. Ribeiro, A. da Silva Morais, J. Oliveira, R. Reis; University of Minho, Guimarães, Portugal

  • 5:30 p.m. 287. Identification of Implant Wear and Corrosion Products within Joint Capsule Tissue by Means of FTIR Imaging, S. Liu, D. Hall, S. McCarthy, J. Jacobs, R. Urban, R. Pourzal*; Rush University Medical Center, Chicago, IL

  • 5:45 p.m. 288. Novel Injectable Newberyite Based Non-exothermic Orthopedic Cements with High Early Strength, N. Rostami, E. Babaie, V. K. Goel, S. B. Bhaduri*; The University of Toledo, N/A, OH

  • 6:00 p.m. 289. Effect of Compliant Layers in Piezoelectric Composite Energy Harvester for Spinal Fusion Applications, E Krech*(1), E Cadel(1), K Tong(1), K Coates(1), L LaPierre(2), E Friis(1); (1)University of Kansas, Lawrence, KS, (2)Evoke Medical, LLC, Thornton, CO

Invited Speaker(s)

  • Jian Yang, PhD

Panel: Cage Match 2018! Academia vs. Industry: Where can you have the Greatest Impact?

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Career and Commercialization
Room: Grand Ballroom A


This free-form and lively panel discussion will pit experts from academia and industry against each other to debate how and where biomaterials scientists can have the biggest impact. This session is targeted at trainees at all levels interested in careers in academia or industry, as well as a general audience. Audience participation will be encouraged.

Invited Speaker(s)

  • David Kohn, PhD
  • Liisa Kuhn, PhD
  • Cherie Stabler, PhD
  • Elaine Duncan, MSME
  • Peter Edelman, PhD
  • Larry Thatcher, PhD

Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering 1

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Drug Delivery
Room: Grand Ballroom D


Due to the versatility and diversity of their materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. The bottom-up approach to designing functional objects at the nanoscale has been used to develop individual nanoparticles or to produce highly oriented complexes for a growing number of applications including drug delivery, imaging, theranostics, vaccines, and cancer immunotherapy. In addition, there are exciting opportunities for local therapeutic modulation. This session highlights recent advances in nanomaterials design aimed to enhance the in vivo delivery of therapeutic or imaging payloads for a variety of diseases including those affecting the skin, gastrointestinal and respiratory tracts, cardiovascular system, cancer, and other diseased tissues.


  • 4:15 p.m. 275. Protein Mimetic and Anticancer Properties of Monocyte-targeting Peptide Amphiphile Micelles, C. Poon*(1), S. Chowdhuri(1), C. Kuo(2), Y. Fang(2), F. Alenghat(2), D. Hyatt(2), K. Kani(1), M. Gross(1), E. Chung(1); (1)University of Southern California, Los Angeles, CA, (2)University of Chicago, Chicago, IL

  • 4:30 p.m. 276. Crosslinked Peptide Nanoclusters for Efficient Delivery of Cancer Antigen, A Tsoras*, J Champion; Georgia Institute of Technology, Atlanta, GA

  • 4:45 p.m. 277. H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy using Molecularly Engineered Theranostic Nanoparticles, D Lee*; Chonbuk National University, Jeonju, Republic of Korea

  • 5:00 p.m. 278. Multi-stage lymphatic delivery system augments lymphoma immunotherapy, A. Schudel*(1), C. Higginson(2), M. Yau(1), M. Finn(1), S. Thomas(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Univeristy of California Berkeley, Berkeley, CA

  • 5:15 p.m. 279. Galectin-enzyme fusion nanoassemblies for prolonged injection site biocatalysis via local glycan binding, S Farhadi, E Bracho-Sanchez, S Freeman, B Keselowsky, G Hudalla*; University of Florida, Gainesville, FL

  • 5:30 p.m. 280. Self-Assembling Nanoparticles with Enhanced Stability, H Acar*(1), G Benuska(2), L Ludwig(2), J LaBelle(2), M Tirrell(2); (1)University of Oklahoma, Norman, OK, (2)The University of Chicago, Chicago, IL

  • 5:45 p.m. 281. Amphiphilic Micelle-Mediated Silencing of MGMT in Glioblastoma Multiforme Tumor Cells In Vivo, A Alexander-Bryant(1), B Hourigan(1), M Lynn(2), J Lee*(1); (1)Clemson University, Clemson, SC, (2)Greenville Health System, Greenville, SC

  • 6:00 p.m. 282. Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity against Mycobacterium tuberculosis, C Chesson(1), R Nusbaum(2), M Huante(3), J Endsley(3), J Rudra*(3); (1)MD Anderson Cancer Center, Houston, TX, (2)University of Pennsylvania, Philadelphia, PA, (3)University of Texas Medical Branch, Galveston, TX

Therapeutic Strategies for the Treatment of Infectious Diseases

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


Greater than 25% of deaths worldwide are caused by infectious diseases. Rising drug resistance and lack in development of new classes of therapeutics have made it increasingly difficult to treat infections. There is a pressing need to engineer advanced antimicrobial therapeutics, delivery systems, and diagnostics that can rapidly and effectively treat and detect infections, while helping to control the spread of resistance. This session will focus on recent advances spanning industry and academia in novel therapeutic strategies for the treatment of bacterial, fungal, viral, and biofilm associated infections. Topics of interest include, but are not limited to: antimicrobial surfaces and device coatings, novel antimicrobial molecules and macromolecules, antimicrobial nano- and micro-particles, and triggered, targeted, and responsive antimicrobial delivery systems. Given the critical importance of detecting infectious agents prior to treating them, new diagnostic technologies for infectious agents are also of interest.


  • 4:15 p.m. 298. Multifunctional polymeric wound dressing materials: combating drug-resistance, J. Lundin*(1), C. McGann(1), L. Estrella(1), E. Cosgriff-Hernandez(2), J. Wynne(1); (1)Naval Research Laboratory, Washington, DC, (2)University of Texas at Austin, Austin, TX

  • 4:30 p.m. 299. Lipid-Coated Mesoporous Silica Nanoparticles for Antiviral Delivery to Inhibit Encephalitic Alphavirus Infection, T. Rinker*(1), A. LaBauve(1), A. Noureddine(2), C. Brinker(2), D. Sasaki(1), O. Negrete(1); (1)Sandia National Laboratories, Livermore, CA, (2)University of New Mexico, Albuquerque, NM

  • 4:45 p.m. 300. Combating Fungal Infections Using Responsive Hydrogels for Drug Delivery, N. Vera-Gonzalez*, A. Shukla; Brown University, Providence, RI

  • 5:00 p.m. 301. WITHDRAWN

  • 5:15 p.m. 302. Preventing S. aureus Biofilm Formation on Titanium Surfaces by the Release of Antimicrobial β peptides from Polyelectrolyte Multilayer Films, A Rodríguez López*, M Lee, D Lynn, S Palecek; University of Wisconsin, Madison, WI

  • 5:30 p.m. 303. Toward creation of poly(methyl methacrylate) bone cement which can be refilled with antibiotics after implantation, E. Cyphert*(1), S. Hurley(2), C. Lu(1), G. Learn(1), H. von Recum(1); (1)Case Western Reserve University, Cleveland, OH, (2)Fordham University, Bronx, NY

  • 5:45 p.m. 304. Anti-Biofilm Efficacy of Nitric Oxide-Releasing Alginates against Respiratory Pathogens, M Ahonen*, M Schoenfisch; University of North Carolina at Chapel Hill, Chapel Hill, NC

  • 6:00 p.m. 305. On-Demand Pressure-Driven Molecular Release for Active Anti-oxidization, Y. Seo*(1), J. Leong(1), J. Teo(1), J. Mitchell(1), M. Gillette(1), B. Han(2), J. Lee(3), H. Kong(4); (1)University of Illinois at Urbana-Champaign, Urbana, IL, (2)Purdue University, West Lafayette, IN, (3)Chung-Ang University, Seoul, Republic of Korea, (4)Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Institute for Genomic Biology, Urbana, IL

Translation of Nanoparticle Contrast Agents for Clinical X-Ray Imaging Modalities

Timeslot: Thursday, April 12, 2018 - 4:15pm to 6:15pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


Iodine and barium sulfate have been the only radiographic contrast agents used in clinical medicine for more than 50 years. However, developments in targeted nanoparticle imaging probes over last decade have brought about a renaissance in X-ray contrast media with potential to transform computed tomography into a molecular imaging modality. This session will highlight translational research on nanoparticle imaging probes for radiography, mammography, CT, dual-energy CT, and spectral (multi-energy) CT. Emphasis will be placed on the fundamental biomaterials science underlying the design and synthesis of nanoparticle imaging probes, their performance in imaging phantoms and preclinical models, and prospects for clinical and commercial translation.


  • 4:15 p.m. 261. Invited Speaker: Benjamin Yeh, MD, University of California, San Francisco 4:38 p.m. 262. Invited Speaker: David Cormode, PhD, Hospital of the University of Pennsylvania

  • 5:00 p.m. 263. An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging, J. Hsu*, P. Naha, K. Lau, R. Hastings, P. Chhour, J. Stein, W. Witschey, A. Maidment, D. Cormode; University of Pennsylvania, Philadelphia, PA

  • 5:15 p.m. 264. A Spectral Library of Nanoparticle Contrast Agents for Molecular Imaging with Computed Tomography, T. Curtis*, P. Nallathamby, R. Roeder; University of Notre Dame, Notre Dame, IN

  • 5:30 p.m. 265. Dextran coated cerium oxide nanoparticles (Dex-CeNP): a novel blood pool CT contrast agent, P. Naha*(1), S. Singh(2), D. Cormode(1); (1)University of Pennsylvania, PHILADELPHIA, PA, (2)Ahmedabad University, Ahmedabad, India

  • 5:45 p.m. 266. Synthesis, Characterization and Pre-clinical Evaluation of Iodinated Polymer Nanoparticles as a Contrast Agent for Computed Tomography using a Spectral Photon counting CT, J. Balegamire*(1), Y. Chevalier(1), H. Fessi(1), M. Vandamme(2), E. Chereul(2), S. Si-Mohamed(3), L. Boussel(3), P. Douek(3); (1)University Claude Bernard Lyon 1 - LAGEP, Villeurbanne, France, (2)VOXCAN, Marcy l'Etoile, France, (3)University Claude Bernar

  • 6:00 p.m. 267. In Vivo Detection of Cancer Stem Cells by Dual Mode CT/Fluorescence Using Immunotargeted Nanoparticle Probes, P Nallathamby*(1), K Dahl(2), R Roeder(1); (1)University of Notre Dame, Notre Dame, IN, (2)Indiana University School of Medicine - South Bend, South Bend, IN

Invited Speaker(s)

  • Benjamin Yeh, PhD
  • David Cormode, PhD