3D Bioprinting for Medical Applications

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


3D bioprinting is becoming widely investigated to fabricate cell-laden biomaterials and medical devices for biomedical applications. Despite this interest, limited progress has been made using 3D bioprinting as a device fabrication tool for clinical applications. This is mainly due to the lack of progress in development of novel bioprinting approaches and bioinks to create self-supporting structures with relevant scales. This session will focus on novel 3D bioprinting approaches and bioink materials.


  • 10:30 a.m. 306. Invited Speaker: Ali Khademhosseini, PhD, UCLA

  • 11:00 a.m. 307. 3D extrusion bioprinting of single- and double-network hydrogels containing dynamic covalent crosslinks, L Wang*, C Highley, Y Yeh, J Galarraga, S Uman, J Burdick; University of Pennsylvania, Philadelphia, PA

  • 11:15 a.m. 308. 3D Bioprinting Multi-Material Tissue Constructs that Modulate Cell-Driven Compaction, T. Hinton*, A. Feinberg; Carnegie Mellon University, Pittsburgh, PA

  • 11:30 a.m. 309. 3D Co-print of Epoxy Resin with Cell-laden Bioink for Custom Shaped Nipple-Areola Skin Grafts, S. Van Belleghem*(1), Z. Mote(1), J. Fisher(1), P. Kim(2); (1)University of Maryland, College Park, MD, (2)Sheikh Zayed Institute for Pediatric Surgical Innovation (Children's National Medical Center), Washington, DC

  • 11:45 a.m. 310. Development of a Universal Bioink Platform Technology for Cross-Platform Compatibility Across Bioprinter Hardware and Support of Multiple Tissue Construct Types, R Huntwork, A Mazzocchi, H Sivakumar, C Clark, J Aleman, M Devarasetty, A Skardal*; Wake Forest School of Medicine, Winston-Salem, NC

  • 12:00 noon 311. Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery, H Wang*, P Agarwal, X He; The Ohio State University, Columbus, OH

  • 12:15 p.m. 312. Cleft Alveolus Reconstruction Using a Three-dimensional Printed Bioresorbable Scaffold with Human Bone Marrow Cells, J Shim*(1), G Ahn(2), J Lee(1), W Yun(1), U Lee(3); (1)Korea Polytechnic University, Siheung-Si, Republic of Korea, (2)T&R Biofab Co. Ltd., Siheung-Si, Republic of Korea, (3)Chung-Ang University Hospital, Seoul, Republic of Korea

Invited Speaker(s)

  • Ali Khademhosseini, PhD

Advances in Bioactive Calcium Phosphate Ceramics and Bioglasses

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Dental/Orthopaedic Biomaterials
Room: 208/209


  • 10:30 a.m. 336. Physical and histological comparison of HAp, CO3Ap, and beta-TCP artificial bone substitutes, K Ishikawa*(1), A Tsuchiya(1), K Hayashi(1), Y Miyamoto(2), K Tsuru(3); (1)Kyushu University, Fukuoka, Japan, (2)Tokushima University, Tokushima, Japan, (3)Fukuoka Dental College, Fukuoka, Japan

  • 10:45 a.m. 337. In Vivo Study of Stable Alpha-TCP Scaffolds Fabricated by Modified Binder Jetting, S. Oyama*(1), M. Watanabe(2), Y. Tsujimura(3), K. Yamazawa(3), H. Yokota(3); (1)Nagoya University, Showa-ku, Nagoya, Japan, (2)Ricoh Company Ltd., Minato-ku, Tokyo, Japan, (3)RIKEN, Wako, Saitama, Japan

  • 11:00 a.m. 338. Maturational changes of octacalcium phosphate and osteoblastic differentiation, O. Suzuki*, T. Anada, Y. Sai, Y. Shiwaku, K. Tsuchiya, T. Takahashi; Tohoku University Graduate School of Dentistry, Sendai, Japan

  • 11:15 a.m. 339. Antimicrobial Effectiveness of Prosidyan FIBERGRAFT® Bone Graft Substitutes, R. Batish*, S Bondre, C Bagga; Prosidyan, Inc., Warren, NJ

  • 11:30 a.m. 340. Porous Calcium Phosphate-Collagen Composite Microspheres for Bone Regeneration, Y Seong*, S Jeong, J Kim, H Kim; Seoul National University, Seoul, Republic of Korea

  • 11:45 a.m. 341. Evaluation of the Nano-Crystalline Hydroxyapatite Forming ability of Novel Bioactive Glass Micro Fiber - Collagen Matrix, C Bagga*, S Bondre; Prosidyan, Inc., Warren, NJ

  • 12:00 noon 342. The Morphology and Conversion of Bone Cement and Borate Bioactive Glass Composites into Magnesium-Substituted Hydroxyapatite, K. Cole*(1), G. Funk(2), T. McIff(2); (1)University of Kansas, Lawrence, KS, (2)University of Kansas Medical Center, Kansas City, KS

  • 12:15 p.m. 343. In situ synthesized calcium phosphate/silk fibroin composites for bone repair applications, M. Nazeer*, E. Yilgör, I. Yilgör; KOÇ University, Istanbul, Turkey

Invited Speaker(s)

  • Kunio Ishikawa, PhD

Biomaterials and Scaffolds for Engineering Vascular Grafts and Blood Vessels

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Tissue Engineering
Room: Grand Ballroom C


In recent years, significant effort has been devoted to developing efficient therapeutic strategies for repair and regeneration of cardiovascular injures. In this regard, biomaterials have played an imperative role in successful delivery of cells and therapeutic compounds as well as in engineering of native like cardiovascular tissue substitutes. To develop proper treatment strategies for CVD, some of the challenges include vascularization of synthetic tissues, renewable cell sources, biomaterials that have similar features to the native cardiovascular tissues, and efficacy in preclinical models. In this session, we will include topics ranging from emerging biomaterials, strategies of vascularization of engineered constructs, and advances in cardiovascular tissue engineering that have shown progress in preclinical settings.


  • 10:30 a.m. 313. Enhanced Hemocompatibility of Ta-implanted ePTFE Vascular Grafts, C Park*, E Song, H Lee, M Lee, H Kim; Seoul National University, Seoul, Republic of Korea

  • 10:45 a.m. 314. Spatially Patterned Atheroprotective Vascular Grafts for Enhanced Patency, K Nakayama*(1), M Kawamura(1), H Wang(2), J Woo(1), N Huang(1); (1)Stanford University, Stanford, CA, (2)Veterans Affairs Palo Alto Health Care System, Palo Alto, CA

  • 11:00 a.m. 315. Resorbable Vascular Grafts Show Early Smooth Muscle Formation in a Porcine Dialysis Access Model, C Stowell*(1), D Celdran-Bonafonte(2), A Jarrouj(2), J Janda(2), Y Wang(1), P Roy-Chaudhury(2); (1)Cornell University, Ithaca, NY, (2)University of Arizona, Tuscon, AZ

  • 11:15 a.m. 316. An Elastomeric Scaffold Functionalized with SDF-1?/CXCL12 Via Covalently Linked Syndecan-4, H Warner*, W Wagner; Wake Forest University School of Medicine, Winston-Salem, NC

  • 11:30 a.m. 317. Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation, C Arakawa*, B Badeau, C DeForest, Y Zheng; University of Washington, Seattle, WA

  • 11:45 a.m. 318. Matrix Anisotropy in Cardiac Differentiation and Cell Sheeting, J Zoldan*, A Allen, L Suggs; The University of Texas at Austin, Austin, TX

  • 12:00 noon 319. The Therapeutic Effect of Fetuin-A on the Calcified State of Smooth Muscle Cells, J. Mosier*, R. Hybart, A. Kay, J. Stewart, C. Simpson; Mississippi State University, Mississippi State, MS

  • 12:15 p.m. 320. Chitosan-TAM Ccomplex for Long-term Monitoring of Tissue Oxygen Content, C Li*, Z Huang, N Gao, H Niu, J Guan; Ohio State University, Columbus, OH

Engineered Biomaterials for Neural Applications

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Biomaterials Applications
Room: 206/207


Researchers are constantly developing and applying new biomaterials to challenging problems of the peripheral and central nervous systems. Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue for better in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells. Presentations will be highly interdisciplinary at the interfaces of biology, chemistry, materials science, engineering, and neuroscience. Target applications of these materials include neural injury, neurodegenerative diseases, stroke, diagnostics, brain-machine interfaces, and brain cancer.


  • 10:30 a.m. 329. Invited Speaker: Aileen Anderson, PhD, University of California, Irvine

  • 11:00 a.m. 330. Injectable and spatially patterned particle hydrogels for tissue repair, E Sideris*, N Darling, T Segura; University of California, Los Angeles, CA

  • 11:15 a.m. 331. pH responsive self-assembling pentapeptide hydrogels with tunable properties for neural tissue engineering, J Tang*, K Lampe; University of Virginia, Charlottesville, VA

  • 11:30 a.m. 332. Adult neural stem cell differentiation in IFN? immobilized chitosan hydrogel conduits, H. Baumann*, L. Shriver, N. Leipzig; University of Akron, Akron, OH

  • 11:45 a.m. 333. Nanofibrous Scaffold Mediated Gene Knockdown for Neuronal Differentiation of Human Neural Stem Cells, W Chooi*, W Ong, A Murray, D Nizetic, S Chew; Nanyang Technological University, Singapore, Singapore

  • 12:00 noon 334. Hyaluronic Acid-Astrocyte Extracellular Matrix Hydrogels Improve Histological Outcomes following Spinal Cord Injury and Support V2a Interneuron Transplantation, R. Thompson*(1), J. Pardieck(2), L. Smith(3), M. Shoichet(3), S. Sakiyama-Elbert(2); (1)Washington University in St Louis, St Louis, MO, (2)University of Texas at Austin, Austin, TX, (3)University of Toronto, Toronto, ON

  • 12:15 p.m. 335. The Effects of A Nanofiber-hydrogel Composite on Neuroprotection after Spinal Cord Injury, X. Li*(1), J. Yan(1), C. Zhang(1), M. Seu(1), Y. Nitobe(2), K. Yamane(2), A. Haggerty(2), I. Lasuncion(2), M. Marlow(2), M. Oudega(2), H. Mao(1); (1)Johns Hopkins University, Baltimore, MD, (2)University of Miami, Miami, FL

Invited Speaker(s)

  • Aileen Anderson, PhD


Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


Carbohydrates, including monosaccharides, oligosaccharides, polysaccharides, and their conjugates, are major components of all living organisms that play a central role in numerous normal and pathological processes. Thus, carbohydrates are gaining interest as both targets and bioactive components of therapeutics and diagnostics for various biomedical and biotechnological applications. Carbohydrate-containing biomaterials (i.e. "glycomaterials") are receiving particular attention because they provide unique opportunities to mimic the multivalent carbohydrate presentation in native glycoconjugates that is often central to carbohydrate function within living systems. This session will highlight recent advances in the synthesis, characterization, and use of glycomaterials to interrogate and harness the biological activity of carbohydrates for biomedical and biotechnological applications. Particular emphasis will be placed on synthetic glycomaterials to probe glycocalyx function, modulate lectin activity, and engage the immune system for infection prophylaxis and immunotherapy.


  • 10:30 a.m. 351. Invited Speaker: Theresa Reineke, PhD, University of Minnesota

  • 11:00 a.m. 352. Development of a Glycocalyx Mimetic, A Panitch*(1), J Wodicka(2), V Morikis(1), A Chambers(2), G Sangha(2), C Goergen(2), S Simon(1); (1)University of California, Davis, CA, (2)Purdue University, West Lafayette, IN

  • 11:15 a.m. 353. Intra-Articular TSG-6 Delivery from Heparin-based Microparticles Reduces Cartilage Damage in a Rat Model of Osteoarthritis, L. Tellier*, E. Treviño, D. Reece, N. Willett, R. Guldberg, J. Temenoff; (1)Georgia Institute of Technology and Emory University, Atlanta, GA, (2)Georgia Institute of Technology, Emory University, and Atlanta Veterans Affairs Center, Atlanta, GA, (3)Georg

  • 11:30 a.m. 354. Hyaluronic Acid Modification Alters CD44 Binding in Soluble and Hydrogel Forms, M. Kwon*(1), C. Wang(2), L. Han(2), R. Mauck(1), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, (2)Drexel University, Philadelphia, PA

  • 11:45 a.m. 355. Viscoelastic Hyaluronic Acid (HA) Hydrogels to Study Hepatic Stellate Cell Mechanobiology, E. Hui*, G. Guan, S. Caliari; University of Virginia, Charlottesville, VA

  • 12:00 noon 356. Glycosylation-dependent hierarchical assembly of low-fouling supramolecular hydrogels, A Restuccia*, G Hudalla; University of Florida, Gainesville, FL

  • 12:15 p.m. 357. Glyco-adjuvant vaccines for enhanced cellular and humoral immunity, D Wilson*, M Raczy, M Swartz, J Hubbell; University of Chicago, Chicago, IL

Invited Speaker(s)

  • Theresa Reineke, PhD

Harnessing Matrix Biology to Control Cell Fate: A Guest Symposium Sponsored by the American Society for Matrix Biology

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Wound Healing and Cellular Microenvironment
Room: Grand Ballroom D


Many subfields within the biomaterials community routinely employ the use of extracellular matrix (ECM) based materials for a variety of purposes, including cell and tissue engineering. ASMB members focus on understanding basic biochemical properties of ECM components in addition to characterizing cellular responses to ECM proteins. The goal of this symposium is to facilitate interactions between biomaterial scientists with synergistic communities that focus on ECM biology. This session invites presentations from researchers in the field that describe biochemical and mechanical properties of ECM components, cell-ECM interactions, and application of ECM-based materials to engineered cellular microenvironments.


  • 10:30 a.m. 344. Invited Speaker: Michael Smith, PhD, Boston University

  • 11:00 a.m. 345. Inflammation-Mediated Provisional Matrix Citrullination Leads to Altered Fibroblast Interactions, V Stefanelli*(1), D Chambers(1), V Yeh(2), K Pesson(1), S Choudhury(1), M Torres(1), T Barker(2); (1)Georgia Institute of Technology, Charlottesville, VA, (2)University of Virginia, Charlottesville, VA

  • 11:15 a.m. 346. Breast Cancer Mechanical Background Controls Motility and Metastasis, A Schwartz*, C Hall, S Duquette, S Peyton; University of Massachusetts Amherst, Amherst, MA

  • 11:30 a.m. 347. Boronate-Based Hydrogels with Fast Relaxation Dynamics for 3D Cell Culture, S. Tang*(1), H. Ma(1), P. Lin(2), K. Anseth(1); (1)University of Colorado Boulder, Boulder, CO, (2)National Sun Yat-sen University, Kaohsiung, Taiwan

  • 11:45 a.m. 348. Synthetic Hydrogels for Human Intestinal Organoid Generation and Colonic Wound Repair, R. Cruz-Acuña*(1), M. Quirós(2), A. Farkas(3), P. Dedhia(4), S. Huang(4), D. Siuda(2), V. García-Hernández(2), A. Miller(4), J. Spence(4), A. Nusrat(2), A. García(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)University of Michigan, Ann Arbor, M

  • 12:00 noon 349. Human Cardiomyocyte Ontogenic Responses to Tissue- and Cell-derived Cardiac Extracellular Matrices, A Silva(1), A Kauss(2), J Perez-Bermejo(3), D Swaney(1), D Joy(1), T Hookway(1), D Nascimento(4), P Pinto-do-Ó(4), T McDevitt*(1); (1)Gladstone Institutes, San Francisco, CA, (2)Gladstone Institutes & UCSF, San Francisco, CA, (3)University of California, San Francisco, San Francisco, CA, (4)Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

  • 12:15 p.m. 350. Force Propagation Through Fibrous Matrices Modulates Endothelial Cell Network Formation, C. Davidson*, W. Wang, V. Chu, B. Baker; University of Michigan, Ann Arbor, MI

Invited Speaker(s)

  • Michael Smith, PhD<

Local Drug, Protein, and Gene Delivery from Implant Surfaces and Coatings

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Drug Delivery
Room: Grand Ballroom B


This general session will focus on the recent advances in locally delivering drugs, proteins, peptides, growth factors, enzymes, and genes from implant surfaces and coatings. Such drug and biomolecule releasing coatings have tremendous applications in cardiovascular devices, orthopedic and fracture fixation devices, craniofacial and dental implants, ophthalmic implants, cochlear implants, and neural devices. This session will cover a wide range of drug and biomolecule eluting implant coatings that include but not limited to novel biodegradable, biostable, and biological polymer coatings, ceramic coatings, porous, textured, microrough, and reservoir surfaces, organic and molecular coatings, selfassembly coatings, solgel coatings, biodegradable metal coatings, thin films, biological and biomimetic coatings. This session will also highlight the importance of different surface characterization techniques to analyze the drug delivery coatings. A special emphasis will be provided to the implant coating technologies that have been translated into clinical and preclinical products.


  • 10:30 a.m. 321. Fluorescent Tagging of Interleukin-4 for Visualizing In-Vivo Release from Coated Polypropylene Mesh, A Nolfi*, D Hachim, A Iftikhar, B Brown; University of Pittsburgh, Pittsburgh, PA

  • 10:45 a.m. 322. In vitro and in vivo mRNA Delivery via poly (2-hydroxyethyl methacrylate) Porous Scaffolds, R. Chen*, H. Zhang, J. Bryers; University of Washington, Seattle, WA

  • 11:00 a.m. 323. Nitric Oxide Releasing Nanomatrix to Enhance Dialysis Fistula Maturation, P Hwang*(1), G Alexander(2), M Somarathna(2), R Milican(1), B Brott(1), J Pollock(2), T Lee(2), H Jun(1); (1)Endomimetics, LLC, Birmingham, AL, (2)University of Alabama at Birmingham, Birmingham, AL

  • 11:15 a.m. 324. Characterization of Carbon Monoxide Releasing Poly(diol-citrate) Polymer for Vascular Applications, D Lichlyter*, A Webb; University of Florida, Gainesville, FL

  • 11:30 a.m. 325. Degradable Devices for Localized Delivery of Immunosuppressants to Prevent Transplant Rejection, J. Molde*(1), K. Dube(1), C. Iovine(1), A. Merolli(1), O. Ortiz(1), J. Steele(1), A. Lellouch(2), Z. Yang Ng(2), I. Schol(2), C. Cetrulo(2), J. Kohn(1); (1)Rutgers University, Piscataway, NJ, (2)Massachusetts General Hospital, Charlestown, MA

  • 11:45 a.m. 326. Controlled Delivery of Local Anesthetics from Novel Biocompatible Wound Dressings, P Alvarez-Urena*, S Bhattacharyya, F Li, P Ducheyne; University of Pennsylvania, Philadelphia, PA

  • 12:00 noon 327. Bioactive Release of Doxycycline from Extracellular Matrix Protein Based Composites, Q. Nguyen*, A. Benton, M. Marquart, A. Janorkar; University of Mississippi Medical Center, Jackson, MS

  • 12:15 p.m. 328. Applying multi-detector GPC/SEC to complex characterization of drug delivery polymers, M. Pothecary*(1), C. Schindler(1), G. Zhang(2), H. Shen(2); (1)Malvern Instruments, Houston, TX, (2)Houston Methodist Research Institute, Housotn, TX

Thought Leader: Philip B. Messersmith

Timeslot: Friday, April 13, 2018 - 10:30am to 12:30pm
Track: Thought Leaders/Ethics
Room: Grand Ballroom A


Biomaterials as coatings and sealants

Invited Speaker(s)

  • Phillip Messersmith, PhD
  • Haeshin Lee, PhD
  • Christopher Bettinger, PhD
  • Bruce Lee, PhD