Biomaterial-Mediated Control of Immunity for Regenerative Medicine

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Biomaterials for Immunity and Cancer
Room: 210/211


Previous strategies to control biomaterial-immune cell interactions involved inhibition of or hiding from immunity. With increasing understanding of the importance of the immune system in mediating tissue repair, next-generation strategies are designed to actively stimulate specific immune cells or promote specific processes in the immune system in order to enhance tissue regeneration. This session will focus on biomaterial design and/or drug delivery strategies to actively control immunity for regenerative medicine applications. Cell targets include neutrophils, monocytes, macrophages, dendritic cells, T cells, and B cells. Biomaterial strategies include drug/cytokine delivery, structural biomimicry, nanomaterials, and tissue engineering strategies.


  • 1:45 p.m. 394. Localizing pro-regenerative inflammation via nanoscale fiber scaffolds improves volumetric muscle defect healing, E Botchwey*, C San Emeterio, M Ogle; Georgia Institute of Technology, Atlanta, GA

  • 2:00 p.m. 395. Sequential Cytokine Delivery for Modification of the Host Immune Response to Implants in the Context of Aging, D Hachim, B Brown*; University of Pittsburgh, Pittsburgh, PA

  • 2:15 p.m. 396. Modulation of Leukocyte Infiltration into Biomaterial Scaffolds Engineered to Release Anti-Inflammatory Small Molecules, K Murphy, M Gower*; University of South Carolina, Columbia, SC

  • 2:30 p.m. 397. Novel Microparticle-based Strategy to Maintain Macrophage Phenotype at Sites of Injury, K Wofford*(1), B Singh(1), K Cullen(2), K Spiller(1); (1)Drexel University, Philadelphia, PA, (2)University of Pennsylvania, Philadelphia, PA

  • 2:45 p.m. 398. A novel "anti-vaccine" for the treatment of collagen-induced arthritis, R Allen*, S Chizari, J Lewis; UC Davis, Davis, CA

  • 3:00 p.m. 399. Allogeneic Ovarian Tissue Encapsulated in Poly(Ethylene Glycol)-Vinyl Sulfone and TheraCyte Immunoisolates and Restores Endocrine Function in Adult Ovariectomized Mice, A David*, J Day, A Lefferts, M Cascalho, A Shikanov; University of Michigan, Ann Arbor, MI

  • 3:15 p.m. 400. Anti-inflammatory Nanomolecules to Modulate Inflammation in a Mouse Model of Crohn's Disease, M. Karver(1), A. Sharma(2), N. Fuller(2), M. Bury*(2); (1)Northwestern University, Chicago, IL, (2)Ann and Robert H. Lurie Childrens Hospital of Chicago, Chicago, IL

  • 3:30 p.m. 401. Understanding the role of macrophages in the FBR-mediated reduction of in vitro osteogenic capabilities of MC3T3-E1 cells encapsulated in a biomimetic poly(ethylene glycol) hydrogel, L. Saleh*, M. Carles-Carner, A. Frederickson, C. Vanderheyden, S. Bryant; University of Colorado, Boulder, CO

Cardiovascular Biomaterials

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Tissue Engineering
Room: 206/207


Cardiovascular therapies harness biomaterials for optimizing biocompatibility, releasing drugs and as scaffolds for tissue regeneration. The session will provide a forum for research on the development and assessment of cardiovascular biomaterial applications across this entire spectrum.


  • 1:45 p.m. 370. Evaluation of Multi-Axial 3D Printed Bioresorbable Vascular Scaffolds For Peripheral Vascular Interventional Application, H. Zhao*(1), J. Zhang(1), Q. Liu(1), Z. Chen(2); (1)Beijing Advanced Medical Technologies Inc, Beijing, China, (2)Beijing Anzhen Hospital, Capital Medical University, Beijing, China

  • 2:00 p.m. 371. In Vivo Sheep and Rabbit Models for Evaluating Low-fouling Zwitterionic Polymer Coatings in Artificial Lungs, R. Ukita*(1), K. Wu(2), X. Lin(2), N. Carleton(1), N. Naito(1), A. Lai(1), C. Do-Nguyen(1), C. Demarest(1), S. Jiang(2), K. Cook(1); (1)Carnegie Mellon University, Pittsburgh, PA, (2)University of Washington, Seattle, WA

  • 2:15 p.m. 372. Elucidating the Role of Graft Compliance Mismatch in Intimal Hyperplasia using an Ex Vivo Organ Culture Model, A. Post*(1), P. Diaz-Rodriguez(2), S. Paulsen(3), J. Miller(3), M. Hahn(2), E. Cosgriff-Hernandez(4); (1)Texas A&M University, Houston, TX, (2)Rensselaer Polytechnic Institute, Troy, NY, (3)Rice University, Houston, TX, (4)The University of Texas at Austi

  • 2:30 p.m. 373. Syndecan-1 in Mechanosensing of Nanotopological Cues, V Le*(1), J Lee(1), S Chaterji(2), A Spencer(1), Y Liu(1), P Kim(3), H Yeh(1), D Kim(3), A Baker(1); (1)University of Texas at Austin, Austin, TX, (2)Purdue University, West Lafayette, IN, (3)University of Washington, Seattle, WA

  • 2:45 p.m. 374. Transmembrane Stem Cell Factor Protein Therapy for Peripheral Vascular Disease using Novel Lipid Carriers, E. Takematsu*(1), J. Auster(1), A. Singh(1), P. Chen(1), S. Canga(1), M. Sherman(2), A. DeGroot(1), A. Dunn(1), A. Baker(1); (1)University of Texas at Austin, Austin, TX, (2)Sealy Center for Structural Biology and Molecular Biophysics, University of Texas

  • 3:00 p.m. 375. Carbon Monoxide Releasing Molecules-Loaded Electrospun Scaffolds Impact Vascular Endothelial Cell Function, K. Washington*, M. Sameti, N. Abeyrathna, C. Martino, Y. Liao, C. Bashur; Florida Institute of Technology, Melbourne, FL

  • 3:15 p.m. 376. Direct Encapsulation of hiPSCs in Gelatin Methacryloyl to Produce Human Engineered Cardiac Tissues, M. Ellis*(1), P. Kerscher(1), J. Kaczmarek(1), S. Head(1), W. Seeto(1), J. Kim(2), S. Bhattacharya(1), V. Suppiramaniam(1), E. Lipke(1); (1)Auburn University, Auburn, AL, (2)Proximity Biosciences, Auburn, AL

  • 3:30 p.m. 377. Self-assembled hydrogels for local, sustained delivery of a small molecule MMP inhibitor after myocardial infarction, J Mealy*(1), S Barlow(2), H Doviak(2), J Jacobs(2), W Torres(2), J Howard(1), F Spinale(2), J Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, (2)University of South Carolina, Columbia, SC

Enzyme-Assisted Biomaterial Fabrication and Modification for Biological Applications

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


Enzymes play critical roles in regulating cellular functions and cell-matrix interactions. Due to their substrate specificity and reaction efficiency, enzymatic reactions are increasingly explored for biomaterials fabrication and modification in a myriad of biomedical applications. This symposium will focus on exploiting specific and efficient enzymatic reactions to fabricate and/or modify biomaterials with preferential properties. Emphasis of the symposium will be on the design principles and novel use of enzymes to prepare/modify fibers, films, hydrogels, scaffolds, particles, or other materials with biologically relevant applications.


  • 1:45 p.m. 362. Synthetic B-cells for fusion-mediated dynamic insulin secretion, G Chen*, Z Chen, J Wang, Z Gu; University of North Carolina at Chapel Hill, Raleigh, NC

  • 2:00 p.m. 363. Reversibly stiffened hydrogels via enzyme-mediated peptide ligation, C. Lin, M. Arkenberg, D. Moore*; Indiana University-Purdue University, Indianapolis, IN

  • 2:15 p.m. 364. Enzyme-Mediated Chemical Modifications of Silk Fibroin Towards Advanced Biofunctional Silk Hydrogels, M. McGill*, D. Kaplan; Tufts University, Medford, MA

  • 2:30 p.m. 365. Sustained Release of Antimicrobial Drugs from Graphene Oxide Immobilized Titanium Surfaces for the Enhanced Antibacterial Activity, D. Tran*, T. Hoang Thi, T. Le, K. Park; Ajou University, Suwon, Republic of Korea

  • 2:45 p.m. 366. Engineering Highly Stable Enzyme-Polymer Conjugates: Molecular Dynamics Simulation Study, S. Tu*(1), C. Choudhury(1), S. Collins(2), N. Yadavalli(3), N. Borodinov(1), I. Luzinov(1), S. Minko(3), O. Kuksenok(1); (1)Clemson University, Clemson, SC, (1)Clemson Univerisity, Clemson, SC, (2)Coe College, Cedar Rapids, IA, (3)The University of Georgi

  • 3:00 p.m. 367. Design of Enzymatically Triggered Shape Memory Polymers, J Henderson(1), P Mather(2), S Buffington*(1), C Lee(2); (1)Syracuse University, Syracuse, NY, (2)Bucknell University, Lewisburg, PA

  • 3:15 p.m. 368. Hypoxia-Inducible Hydrogels via Enzyme-Immobilization, B. Hudson*(1), H. Liu(2), C. Dawes(1), C. Lin(1); (1)Indiana University-Purdue University, Indianapolis, IN, (2)Purdue University, West Lafayette, IN

  • 3:30 p.m. 369. Controlled Cell Migration within Cell Selective Hydrogels, E Pashuck*, N Joshi, S Fung, K Kim, J Kohn; Rutgers University, Piscataway, NJ

Panel: Challenges to and Opportunities for Implementing Regenerative Biomaterials in Patient Care

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Career and Commercialization
Room: Grand Ballroom C


Regenerative Engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and clinical translation to develop innovative, scalable tools to regenerate damaged or diseased complex tissues and organs.


  • 358. Cato T. Laurencin, MD, PhD, UCHC

  • 359. Raphael Lee

  • 360. Jennifer Elisseeff

  • 361. Jim Malaytar

Invited Speaker(s)

  • Cato T. Laurencin, MD, PhD
  • Raphael Lee, PhD
  • Jennifer Elisseeff, PhD
  • Jim Malaytar, PhD

Panel: Spinning Academic Research into Startup Companies

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Career and Commercialization
Room: Grand Ballroom B


The process of spinning academic research into startup companies is challenging and the success rate of academic startups is very low. A main cause to the low success rate is a lack of knowledge of the process, which leads to unrealistic expectations and inadequate planning. The purpose of this session is to educate scientists on how to spin academic research into startup companies and what common challenges to expect during the process. We plan to invite 3-4 guest speakers who had been through this process successfully to each give a presentation and answer questions. The speakers will share their experiences and give their advices. We hope this session will help to improve the success rate of converting academic research into products.

Invited Speaker(s)

  • Sarah Mayes, PhD
  • Pratap Khanwilkar, PhD

Protein and Cells Interfaces

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Wound Healing and Cellular Microenvironment
Room: 208/209


The goal of this broad session is to advance the understanding of cell and protein interactions with natural and synthetic biomaterials. Recent advances related to the mechanistic interactions with existing biomaterials and the design of new materials to produce targeted responses by proteins and cells are encouraged. Topics of interest include, but are not limited to: 1) relating surface chemistry to protein adsorption or specific binding; 2) studying the activation or inactivation of protein function at interfaces, including complement activation; 3) the response of cells to materials with varied chemistries, mechanical properties and micro- or nano-structured surfaces; 4) the evaluation of cell and tissue responses to biomaterials with respect to changes in function or fate; and 5) the role of surface receptors in cell responses, including mammalian and microbial cell types.


  • 1:45 p.m. 386. Contact Activation by The Intrinsic Pathway of Blood Plasma Coagulation, L. Xu, Y. Yan, C. Siedlecki*; The Pennsylvania State University College of Medicine, Hershey, PA

  • 2:00 p.m. 387. A Visual Study of the SynB1-Elastin Like Polypeptide Agglomeration, A. Janorkar, J. Correia, V. Zai-Rose, J. Cobb*; The University of Mississippi Medical Center, Jackson, MS

  • 2:15 p.m. 388. Toll-like Receptor 2-mediated Inflammatory Response to Polymeric Biomaterials, L McKiel, L Fitzpatrick*; Queen's University, Kingston, ON

  • 2:30 p.m. 389. Elucidating Valve Interstitial Cell-ECM Biomechanical Interactions Using Poly(ethylene glycol) Hydrogels, A Khang*(1), A Gonzalez Rodriguez(2), M Schroeder(2), K Anseth(2), M Sacks(1); (1)The University of Texas at Austin, Austin, TX, (2)University of Colorado Boulder, Boulder, CO

  • 2:45 p.m. 390. Covalent tethering of signaling proteins to hydrogels through a reversible thiol-ene bioconjugation, J Grim*(1), B Aguado(1), T Brown(1), K Anseth(2); (1)University of Colorado Boulder, Boulder, CO, (2)University of Colorado Boulder, BioFronteirs Institute, Boulder, CO

  • 3:00 p.m. 391. Engineered Microtopographies to Guide and Control Cellular Response of Fibroblasts and Schwann Cells: SharkletTM Versus Channels, S Mobini*, C Kuliasha, N Bohmann, J Judy, K Otto, C Schmidt, A Brennan; University of Florida, Gainesville, FL

  • 3:15 p.m. 392. Influence of Chitosan-Alginate Scaffold Stiffness on Bone Marrow Stromal Cell Differentiation, I Arias*, M Le, B Ding, K Xu, Z Wang, S Florczyk; University of Central Florida, Orlando, FL

  • 3:30 p.m. 393. Cellular interactions and bone affinity of poly(ethylene sodium phosphate), Y Iwasaki*; Kansai University, Osaka, Japan

Supramolecular Nanomaterials for Drug Delivery, Imaging, and Immunoengineering 2

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Drug Delivery
Room: Grand Ballroom D


Due to the versatility and diversity of their materials properties, a wide range of biomedical applications have emerged in recent years using supramolecular nanomaterials. The bottom-up approach to designing functional objects at the nanoscale has been used to develop individual nanoparticles or to produce highly oriented complexes for a growing number of applications including drug delivery, imaging, theranostics, vaccines, and cancer immunotherapy. In addition, there are exciting opportunities for local therapeutic modulation. This session highlights recent advances in nanomaterials design aimed to enhance the in vivo delivery of therapeutic or imaging payloads for a variety of diseases including those affecting the skin, gastrointestinal and respiratory tracts, cardiovascular system, cancer, and other diseased tissues.


  • 1:45 p.m. 378. Supramolecular tools for modulating the morphology of self-assembled helical peptide nanofibers, C Fries*, J Collier, Y Wu, M Wolf; Duke University, Durham, NC

  • 2:00 p.m. 379. Dynamic light scattering of bottlebrush polymers, A Kriete*, K Prudnikova, M Marcolongo; Drexel University, Philadelphia, PA

  • 2:15 p.m. 380. Optimizing Mannose Conjugation to Polymeric Nanoparticles for Targeted Delivery to Tumor Associated Macrophages in Breast Cancer, E. Glass*, S. Masjedi, S. Dudzinski, T. Giorgio; Vanderbilt University, Nashville, TN

  • 2:30 p.m. 381. Multiarm Avidin Nanoconstruct as a Cationic Carrier for Intra-cartilage Drug Delivery, A Vedadghavami, S Mehta, A Bajpayee*, S Bhakta; Northeastern University, Boston, MA

  • 2:45 p.m. 382. Biomimetic peptide display from a polymeric nanoparticle surface for dual functionality to target and treat cancer, J. Green*(1), J. Kim(1), E. Bressler(2), R. Shmueli(1), A. Mirando(1), H. Bazzazi(1), E. Lee(1), A. Popel(1), N. Pandey(1); (1)Johns Hopkins University, Baltimore, MD, (2)AsclepiX Therapeutics, Baltimore, MD

  • 3:00 p.m. 383. Subconjunctival delivery of nanoparticles for safe and efficient treatment of corneal allograft rejection, Q. Xu*(1), M. Chen(2), Q. Pan(2), W. Stark(2), J. Hanes(2); (1)Virginia Commonwealth University, Richmond, VA, (2)Johns Hopkins University, Baltimore, MD

  • 3:15 p.m. 384. Aggregation Behavior of Elastin-Like Polypeptide Copolymers, A. Engel*, J. Cobb, A. Janorkar; Univ. of Mississippi Med Center, Jackson, MS

  • 3:30 p.m. 385. Immunomodulatory Vasoactive Intestinal Peptide Amphiphile Micelles, R. Zhang*, C. Leeper, X. Wang, G. Seim, B. Ulery; University of Missouri, Columbia, MO

Thought Leader: Linda Griffith

Timeslot: Friday, April 13, 2018 - 1:45pm to 3:45pm
Track: Thought Leaders/Ethics
Room: Grand Ballroom A


Modeling Immunology and Inflammation