Engineered Microenvironments to Model Cancer

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Wound Healing and Cellular Microenvironment
Room: Grand Ballroom D


Biomaterials have been invaluable tools for understanding how cells respond to their microenvironment in both health and disease. Here, we invite contributions that develop biomaterial platforms for cell culture or tissue engineering. Session topics include the following: understanding of the mechanisms that determine cellular responses to disease/injury, determining how biophysical and biochemical cues alter cellular behavior in 3D, identifying differences between 2D and 3D microenvironments in mediating cellular phenotype or response to treatment, developing complex tissue microstructures/organioids, culturing multiple types of cells within complex microenvironments, driving or enriching specific populations, developing improved approaches for utilization of patient derived or difficult to culture cells, drug screening within engineered microenvironments, and engineering microenvironments for therapeutic purposes.


  • 10:15 a.m. 456. Tunable Biomaterials to Identify Mechanisms of ECM-Mediated Drug Resistance in Breast Cancer, A Schwartz*(1), L Barney(1), L Jansen(1), T Nguyen(1), C Hall(1), A Meyer(2), S Peyton(1); (1)University of Massachusetts Amherst, Amherst, MA, (2)Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA

  • 10:30 a.m. 457. 3D in vitro Recapitulation of the Native Breast Tumor Microenvironment in a Vascularized Tumor Mimetic Microfluidic Chip, B Anbiah*(1), I Hassani(1), N Habbit(1), S Jasper(1), M Egghert(1), B Prabhakarpandian(2), R Arnold(1), E Lipke(1); (1)Auburn University, Auburn, AL, (2)Biomedical technology, CFD Research Corporation, Huntsville, AL

  • 10:45 a.m. 458. Desmoplasia-mimetic gels with modular and temporal properties for modeling pancreatic cancer progression, H. Liu*(1), C. Lin(2); (1)Purdue University, West Lafayette, IN, (2)IUPUI, Indianapolis, IN

  • 11:00 a.m. 459. Mineralized matrices to model malignant microcalcification-induced breast tumor progression, M Singh, A Patel, S Rangnathan, S Sant*; University of Pittsburgh, Pittsburgh, PA

  • 11:15 a.m. 460. Designer tumor microenvironments to study B cell lymphoid tumors and MALT1 signaling, S. Shah*(1), E. Abeles(1), K. Lee(1), L. Fontan(2), A. Melnick(2), A. Singh(1); (1)Cornell University, Ithaca, NY, (2)Weill Cornell Medical College, New York, NY

  • 11:30 a.m. 461. Perivascular Signals Alter Global Genomic Profile of Glioblastoma and Response to Temozolomide in an Engineered Tumor Microenvironment, M. Ngo*, B. Harley; University of Illinois Urbana-Champaign, Urbana, IL

  • 11:45 a.m. 462. Glioblastoma stem cell phenotype regulation via CD44 on tumor microenvironment mimicking hyaluronic acid hydrogel, S. Park*, A. Narkhede, S. Rao, Y. Kim; The University of Alabama, Tuscaloosa, AL

  • 12:00 noon 463. Development of a 3D Scaffold for Modelling Aggressive Lymphoma, L. Bahlmann*(1), A. Baker(1), R. Laister(2), M. Shoichet(1); (1)University of Toronto, Toronto, ON, (2)Cancer Institute, Princess Margaret Hospital, Toronto, ON

Materials for Cardiovascular Devices and Blood Compatibility

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Applications
Room: 208/209


Thrombosis is often a major concern with cardiovascular medical devices such as stents, vascular grafts, heart valves, pacemakers, defibrillators, ventricular assist devices, cardiopulmonary bypass, and artificial heart. Although significant progress has been made in developing and using a wide variety of metallic, polymeric, ceramic, and natural biomaterials for making cardiovascular medical devices, still the blood compatibility of these devices remains an issue. This symposium will focus on (i) recent developments in cardiovascular biomaterials for improving blood compatibility? (ii) the development of novel biomaterials for cardiovascular medical device applications? (iii) novel coatings and surface modification technologies for improving blood compatibility? (iv) recent developments in in vitro and in vivo evaluation of blood compatibility of biomaterials and medical devices? (v) clinical evaluation of cardiovascular medical devices? (vi) novel approaches to improve endothelialization of cardiovascular implants and devices.


  • 10:15 a.m. 433. Bacteria and Blood Coagulation Responses to Textured/Nitric Oxide Releasing Biomaterial Surfaces, L. Xu*(1), D. Sun(1), T. Wood(2), M. Meyerhoff(3), C. Siedlecki(4); (1)The Pennsylvania State University College of Medicine, Hershey, PA, (2)The Pennsylvania State University, University Park, PA, (3)University of Michigan, Ann Arbor, MI, (4)Penn State u

  • 10:30 a.m. 434. Thrombogenicity Evaluation of Medical Device Materials with an In Vitro Flow Loop System Under Varying Flow Conditions, M. Jamiolkowski, M. Golding, Z. Goddard, R. Malinauskas, Q. Lu*; US Food and Drug Administration, Silver Spring, MD

  • 10:45 a.m. 435. In Vitro Accelerated Fatigue Study of Chimney Stent-grafts Deployed in a Patient's Aortic Aneurysm Phantom, R Zhang*(1), S Crawford(2), I Robertson(3), S Marks(4), M King(1); (1)North Carolina State University, Raleigh, NC, (2)Vascular Surgery, Toronto, ON, (3)NC State Veterinary Hospital, Raleigh, NC, (4)Critical Care and Internal Medicine, Raleigh, NC

  • 11:00 a.m. 436. Design of a shape memory polymer, poly-glycerol dodecanoate, and small intestinal submucosa (Cormatrix®) composite material for atrial septal defect occlusion in a porcine model, H Ramaraju*(1), L Solorio(2), M Bocks(3), S Hollister(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Cook Biotech Inc, West Lafayette, IN, (3)UH Rainbow Babies and Children's Hospital, Cleveland, OH

  • 11:15 a.m. 437. Heparin-functionalized polymer graft surface eluting MK2 inhibitory peptide for vascular graft applications, Y Lee*(1), P Le Thi(2), G Seon(3), C Brophy(4), Y Kim(1), J Park(3), K Park(2), J Cheung-Flynn(4), H Sung(3); (1)Georgia Institute of Technology, Atlanta, GA, (2)Ajou University, Suwon, Republic of Korea, (3)Yonsei University College of Medicine, Seoul, Republic of Korea

  • 11:30 a.m. 438. Surface fluorination of polylactides for enhanced hemocompatibility, R Khalifehzadeh*, B D.Ratner; University of Washington, Seattle, WA

  • 11:45 a.m. 439. Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions, G. Alexander*(1), P. Hwang(1), J. Chen(1), J. Kim(1), B. Brott(1), Y. Yoon(2), H. Jun(1); (1)University of Alabama at Birmingham, Birmingham, AL, (2)Emory University, Atlanta, GA

  • 12:00 noon 440. In-vitro oxidative stability of high strength siloxane poly(urethane-urea) elastomers developed for heart valve application, L Dandeniyage*(1), P Gunatillake(2), R Adhikari(2), M Bown(2), R Shanks(3), B Adhikari(3); (1)RMIT University / Commonwealth Scientific and Industrial Research Organisation (CSIRO), Melbourne, Australia, (2)Commonwealth Scientific and Industrial Research

Nano Materials

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Fabrication and Analysis
Room: 204/205


The nanoscience and nanotechnology of biomaterials involves the unique science and technology present in biomaterials at the nanoscale and their related biological effects. Such nanobiomaterials present the creation of new and better biomaterials and devices, diagnostics and therapeutics for biomedical applications.


  • 10:15 a.m. 410. Multiple Functions of Cancer Targeting, Imaging and Photothermal Therapy by Au-based Theranostics Released from Advanced Tissue Engineering Scaffolds, L. Guo*, M. Wang; The University of Hong Kong, Hong Kong, Hong Kong

  • 10:30 a.m. 411. NIR-Induced Spatiotemporally Controlled Gene Silencing by Upconversion Nanoparticle-based siRNA Nanocarrier, G. Chen(1), B. Ma(1), R. Xie(1), Y. Wang(1), K. Dou(2), S. Gong*(1); (1)University of Wisconsin-Madison, Madison, WI, (2)Fourth Military Medical University, Xi'an, China

  • 10:45 a.m. 412. Whole-Transcriptome Analysis of Human Stem Cells Treated with Two-Dimensional Nanosilicates, J Carrow*(1), L Cross(1), R Reese(1), R Kaunas(1), I Singh(2), A Gaharwar(1); (1)Texas A&M University, College Station, TX, (2)Cornell University, New York, NY

  • 11:00 a.m. 413. Manganese dioxide nanoparticles protect cytokine-challenged cartilage from oxidative stress, S Kumar*, I Adjei, B Sharma; University of Florida, Gainesville, FL

  • 11:15 a.m. 414. Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery, J. Melamed*, N. Kreuzberger, E. Day; University of Delaware, Newark, DE

  • 11:30 a.m. 415. Cell-Cell Anchor Molecules for 3D-Cell Micropatterning on Cell/Tissue Surfaces, M. Matsusaki*, K. Yanagisawa; Osaka University, Osaka, Japan

  • 11:45 a.m. 416. Nanoparticle-based Molecular Beacon for Small RNA Detection by Gold Nanoparticles and Upconversion Nanoparticles, Y Sun*, C Mao; University of Oklahoma, Norman, OK

  • 12:00 noon 417. Site-Selective RNA Splicing Nanozyme: DNAzyme and RtcB Conjugates on a Gold Nanoparticle, J. Petree*(1), K. Yehl(1), K. Galior(1), R. Glazier(2), B. Deal(1), K. Salaita(1); (1)Emory University, Atlanta, GA, (2)Georgia Institute of Technology, Atlanta, GA

Opthalmic Biomaterials SIG

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Applications
Room: 210/211


The Ophthalmic Biomaterials SIG Session welcomes submissions that describe the development and/or testing of biomaterials for use in ophthalmology. This may include drug delivery strategies or cell-based approaches, regenerative medicine applications, or unique animal models that have a primary focus in preserving or restoring the form and/or function of the eye. Abstracts from related areas of research with strong applicability in the visual system may also be submitted for this SIG Session.


  • 10:15 a.m. 441. Engineering a Regeneration Permissive Substrate as Therapeutics for Retinal Degeneration, J Kundu*(1), P Baranov(2), S Kim(3), A Yandulskaya(1), J Monaghan(1), R Linhardt(3), M Young(2), R Carrier(1); (1)Northeastern University, Boston, MA, (2)Schepens Eye Research Institute, Boston, MA, (3)Rensselaer Polytechnic Institute, Troy, NY

  • 10:30 a.m. 442. Posterior Ocular Drug Delivery for Treatment of Wet-AMD using Injectable, Degradable POEGMA Hydrogels, E Paron*, B Muirhead, H Sheardown, T Hoare; McMaster University, Hamilton, ON

  • 10:45 a.m. 443. ATRP Surface Modification of Contact Lenses for Improving Lens Comfort by Interacting of PolyAPBA and Polysaccharide Wetting Agents, H Sheardown*, L Liu; McMaster University, Hamilton, ON

  • 11:00 a.m. 444. Preliminary, In Vitro Optimization of a Controlled Release Cysteamine Eye Drop, J Jimenez*, M Washington, M Fedorchak, K Nischal; University of Pittsburgh, Pittsburgh, PA

  • 11:15 a.m. 445. Properties of IOLs after Gamma Radiation, C. Hu*, F. Chen, M. Lowery; Johnson & Johnson Vision, Santa Ana, CA

  • 11:30 a.m. 446. Carboxymethylated Hyaluronic Acid-based Delivery of Small Molecule to Ocular Surface, H. Lee*, S. Luo, B. Wirostko, B. Mann; Eyegate Pharmaceuticals Inc., Salt Lake City, UT

  • 11:45 a.m. 447. Polyethylene Glycol Methacrylate-Based Polymeric Micelles for Ocular Drug Delivery, H Sheardown(1), J Leung*(2); (1)McMaster Engineering, Hamilton, ON, (2)McMaster University, Hamilton, ON

  • 12:00 noon 448. Delivery of Stem Cells using Biomimetic Materials Designed for Ocular Surface Repair, B Janet(1), B Corliss(2), L Costella*(1), K Broderick(1), R Redmond(3), A Eiseman(4), C Tison(1); (1)Luna Innovations, Charlottesville, VA, (2)University of Virginia, Charlottesville, VA, (3)Harvard Medical School, Boston, MA, (4)Medical University of Sou

Orthopaedic Biomaterials

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Dental/Orthopaedic Biomaterials
Room: Grand Ballroom B


Orthopaedic biomaterials may include all kinds of biomaterials for orthopaedic applications (e.g., bone implant/scaffold, 3D printing, drug delivery) and related biological effects. Such biomaterials may include metals, ceramics, polymers, composites, coatings, biodegradables, etc.


  • 10:15 a.m. 449. Invited Speaker: Noreen Hickok, PhD, Thomas Jefferson University

  • 10:45 a.m. 450. Decorin-Supplemented Collagen Scaffolds for Co-Delivery of Microvascular Fragments and Bone Morphogenetic Protein 2, M. Ruehle*(1), L. Krishnan(1), N. Willett(2), R. Guldberg(1); (1)Georgia Institute of Technology, Atlanta, GA, (2)Emory University, Atlanta, GA

  • 11:00 a.m. 451. Bisphosphonates Inhibit Bone Marrow Recovery following Injury, D Cohen*, E Lotz, P Daire, I Nalic, V Patel, B Boyan, Z Schwartz; Virginia Commonwealth University, Richmond, VA

  • 11:15 a.m. 452. Mechanisms for Mechanically Assisted Electrochemical Degradation of Alumina-TiC Composite, H Maharaja*, G Zhang; Clemson University, Clemson, SC

  • 11:30 a.m. 453. Large-scale Fabrication of Highly Aligned and Mechanically Robust Nanofiber Scaffolds as Orthopaedic Biomaterials, S. Zhang*(1), B. Ding(2), B. Li(1); (1)West Virginia University, Morgantown, WV, (2)Donghua University, Shanghai, China

  • 11:45 a.m. 454. Does Macrophage Polarization Modulate Cell Induced Corrosion in CoCrMo alloy?, S. Salunkhe*(1), D. Bijukumar(1), G. Zheng(1), D. Hall(2), M. Mathew(1), R. Pourzal(2); (1)University of Illinois College of Medicine at Rockford, Rockford, IL, (2)Rush University Medical Center, Chicago, IL

  • 12:00 noon 455. Multi-Laminate, Angle-Ply Annulus Fibrosus Repair Implant Injected with Glycosaminoglycan Gel Demonstrates Increased Biaxial Impact Resistance and Restores Spinal Kinematics, R. Borem*(1), J. Walters(1), A. Madeline(1), R. Vela(1), S. Gill(2), J. Mercuri(1); (1)Clemson University, Clemson, SC, (2)Spartanburg Regional Healthcare, Greer, SC

Invited Speaker(s)

  • Noreen J. Hickok, PhD

Supramolecular Design of Network Biomaterials

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Fabrication and Analysis
Room: 206/207


The preparation of biomaterials using rationally designed motifs rooted in supramolecular chemistry (i.e., "chemistry beyond the molecule") affords properties that are reversible, highly tunable, and dynamic, and as such has become an exciting new direction in the field of engineered biomaterials. The reliance on specific, noncovalent interactions affords opportunities in developing materials with “smart” functionality and activity that can be tuned in response to disease or application, and as injectable surrogate matrices for cells. Moreover, conserving the specific supramolecular motif realizes a modular approach to customize a biomaterial in a patient or disease specific way. These efforts have resulted in a suite of new and highly functional network biomaterials for applications in stem cell biology, regenerative medicine, tissue engineering, and drug delivery. In each case, unique features rooted in supramolecular design give rise to important emergent properties.


  • 10:15 a.m. 418. Adaptable Biomaterials for Expansion and Transplantation of Stem Cells, C. Madl, B. LeSavage, R. Dewi, S. Heilshorn*; Stanford University, Stanford, CA

  • 10:45 a.m. 419. Tailoring supramolecular guest-host hydrogel properties with covalent double networks, C. Loebel*(1), A. Ayoub(2), J. Galarraga(1), O. Kossover(2), H. Simaan-Yameen(2), D. Seliktar(2), J. Burdick(1); (1)University of Pennsylvania, Philadelphia, PA, (2)Technion – Israel Institute of Technology, Haifa, Israel

  • 11:00 a.m. 420. Supramolecular Vesicles Transitioned from Coacervates Composed of Recombinant Fusion Protein Complexes, Y Jang*, M Hsieh, S Guo, M Grover, J Champion; Georgia Institute of Technology, Atlanta, GA

  • 11:15 a.m. 421. WITHDRAWN

  • 11:30 a.m. 422. Photolymerized Dynamic Hydrogels with Tunable Viscoelastic Properties Through Thioester Exchange, B. Carberry*(1), T. Brown(1), B. Worrell(1), O. Dudaryeva(2), M. Mcbride(1), C. Bowman(1), K. Anseth(1); (1)University of Colorado at Boulder, Boulder, CO, (2)Institute for Complex Molecular Systems, Eindhoven, Netherlands

  • 11:45 a.m. 423. A Thermo-Responsive Citrate-based Macromolecule for Transarterial Embolotherapy, S. Ramachandra*(1), J. Yang(1), S. Lee(2), G. Ameer(1); (1)Northwestern University, Evanston, IL, (2)University of Chicago, Chicago, IL

  • 12:00 noon 424. Supramolecular peptide and protein matrices for prostate cancer organoid culture, K Hainline*(1), F Gu(1), D Vander Griend(2), J Collier(1); (1)Duke University, Durham, NC, (2)University of Chicago, Chicago, IL

Invited Speaker(s)

  • Sarah Heilshorn, PhD

Surface Characterization and Modification

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Biomaterials Fabrication and Analysis
Room: Grand Ballroom A


Some research areas that fall under these topics include polymer coatings, grafting, plasma polymerization/treatment, self-assembled coatings, thin film deposition, surface modifications such chemical and ion surface modifications; spectroscopic, microscopic, and biochemical surface characterization; device-tissue interactions, non-fouling surfaces, antimicrobial coatings, and other implantable medical devices.


  • 10:15 a.m. 402. Covalent Grafting of Antifouling Polyzwitterion with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties, P. Singha*, Q. Liu, J. Locklin, H. Handa; University of Georgia, Athens, GA

  • 10:30 a.m. 403. Long Term Nitric Oxide Releasing Polydimethylsiloxane for Implantable Medical Device Applications, S. Hopkins*, J. Pant, M. Goudie, H. Handa; University of Georgia, Athens, GA

  • 10:45 a.m. 404. Surface Modification of Alkyne-Functionalized Poly(lactic-co-glycolic acid) Particles for Breast Cancer Stem Cell Targeting, K. McEnnis*(1), S. Rahmani(2), S. McDermott(3), S. Roghani Esfahani(4), J. Lahann(4); (1)New Jersey Institute of Technology, Newark, NJ, (2)Harvard University, Cambridge, MA, (3)Frederick National Lab for Cancer Research, Frederick, MD, (4)University of M

  • 11:00 a.m. 405. Surface Characterization of Ionic Liquid Coatings on Biomaterial Substrates, D Siddiqui*, M Ammanamanchi, P Sandhu, I Gindri, D Rodrigues; The University of Texas at Dallas, Richardson, TX

  • 11:15 a.m. 406. Evaluation of S-nitroso-N-acetylpenicillamine (SNAP)-based polymer from a translational perspective, E. Brisbois*(1), M. Goudie(2), J. Pant(2), H. Handa(2); (1)University of Central Florida, Orlando, FL, (2)University of Georgia, Athens, GA

  • 11:30 a.m. 407. Photocatalytic Activity and Osteoblast Viability of UV-Treated Titanium Oxides, H. Johnson*(1), P. Pal(2), A. Janorkar(1), R. Williamson(1), M. Roach(1); (1)University of Mississippi Medical Center, Jackson, MS, (2)University of Mississippi, Jackson, MS

  • 11:45 a.m. 408. Surface Modification of Polypropylene Surgical Meshes for Improving Adhesion with Poloxamine Hydrogel Adhesive, X. Lu*, A. Khanna, I. Luzinov, J. Nagatomi, M. Harman; Clemson University, Clemson, SC

  • 12:00 noon 409. Nanostructured amorphous magnesium phosphate / poly (lactic acid) composite coating for enhanced corrosion resistance and bioactivity of biodegradable AZ31 magnesium alloy, Y Ren, E Babaie, S Bhaduri*; The University of Toledo, Toledo, OH

Tissue Engineering

Timeslot: Saturday, April 14, 2018 - 10:15am to 12:15pm
Track: Tissue Engineering
Room: Grand Ballroom C


  • 10:15 a.m. 425. Improved hMSC Seeding and Surface Modification of 3D Printed Bone Grafts, P. Dhavalikar*(1), M. Whitely(2), S. Cereceres(2), K. Kapilov-Buchman(3), T. Wilems(1), M. Silverstein(3), E. Cosgriff-Hernandez(1); (1)University of Texas at Austin, Austin, TX, (2)Texas A&M University, College Station, TX, (3)Technion - Israel Institute

  • 10:30 a.m. 426. An Injectable and Settable Poly(thioketal urethane) Autograft Extender for Grafting Open Fractures, M McGough*(1), S Shiels(2), L Boller(1), J Wenke(2), S Guelcher(1); (1)Vanderbilt University, Nashville, TN, (2)US Army Institute of Surgical Research, San Antonio, TX

  • 10:45 a.m. 427. Linking the cellular microenvironment to macroscopic properties of cell-laden photopolymerized hydrogels, S Chu*, K Calahan, P Bhusal, S Lalitha Sridhar, M Maples, F Vernerey, S Bryant; University of Colorado Boulder, Boulder, CO

  • 11:00 a.m. 428. Controlling Cell Cluster Parameter for Improved Cartilage Tissue Engineering in Photoclickable PEG Hydrogels, M. Schneider*, S. Lalitha Sridhar, F. Vernerey, S. Bryant; University of Colorado-Boulder, Boulder, CO

  • 11:15 a.m. 429. Production of Cardiac Tissue Spheroids using a Novel Microfluidic System, F. Finklea*, Y. Tian, P. Kerscher, W. Seeto, E. Lipke; Auburn University, Auburn, AL

  • 11:30 a.m. 430. Two-dimensional Nanosilicates for Therapeutic Protein Delivery, L. Cross*, J. Carrow, M. Muscarello, A. Gaharwar; Texas A&M University, College Station, TX

  • 11:45 a.m. 431. Biomimetic Elastin-Containing Bi-layered Scaffold for Vascular Tissue Engineering, T. Nguyen*, M. Shojaee, C. Bashur, V. Kishore; Florida Institute of Technology, Melbourne, FL

  • 12:00 noon 432. Theranostics-embedded and Growth Factor-incorporated Multifunctional Scaffolds for Post-surgery Cancer Patients, L. Guo*, M. Wang; The University of Hong Kong, Hong Kong, Hong Kong