Rapid Fire Presentations

Antimicrobial Drug Delivery in Infectious Diseases

300. In vitro Comparison of Harvesting Site Effects on Cardiac Extracellular Matrix Hydrogels, Emily Mulvany1, Sara McMahan2, Jiazhu Xu, MS2, Narges Yazdani1, Rebecca Willits, PhD1, Jun Liao, PhD2, Ge Zhang, MD/PhD1, Yi Hong, PhD2 1 The University of Aktron, Akron, OH, USA, 2University of Texas at Arlington, Arlington, TX, USA

301. Effective Delivery of Peptides by Janus-type Dressings for Combating Biofilms in Chronic Wounds, Jingwei Xie, PhD, Yajuan Su, PhD, Hongjun Wang, Guangshun Wang, PhD University of Nebraska Medical Center, Omaha, NE, USA

302. Addition of Manuka Honey to Mineralized Collagen Scaffolds for Bone Repair and Preventing Bacterial Adhesion, Marley Dewey1, Alan Collins, PhD2, Vasiliki Kollipoulos1, Aleczandria Tiffany1, Rachel Whitaker, PhD2, Brendan Harley, Sc.D1,21University of Illinois at Urbana-Champaign, Urbana, IL, USA, 2Institute of Genomic Biology, Urbana, IL, USA

303. Absorption of a Novel Antimicrobial Peptide into Orthopedic Bone Cement, Grahmm Funk, BS, BS1, Kyle Boone, PhD2, Candan Tamerler, PhD2, Terence McIff, PhD, MBA11University of Kansas Medical Center, Kansas City, KS, USA, 2University of Kansas, Lawrence, KS, USA

304. Novel Polypeptide Coatings with Controlled Dual Drug Delivery, Bingyun Li, PhD, Shichao Zhang, West Virginia University, Morgantown, WV, USA

305. In vitro evaluation of anesthetic-loaded chitosan membranes for infection prevention, Zoe Harrison, MS1, Joel Bumgardner, PhD1, Tomoko Fujiwara, PhD2, Daniel Baker, PhD2, Jessica Jennings, PhD11The University of Memphis, Memphis, TN, USA, 2University of Memphis, Memphis, TN, USA

306. A Clear(ly) Promising Solution: Glutathione-conjugated Hydrogels for the Treatment of Bacterial Infections, Karol Sokolowski, Catherine Dial, Zackery Bulman, PharmD, Eric Wenzler, PharmD, Richard Gemeinhart, PhD, University of Illinois at Chicago, Chicago, IL, USA

307. Drug-eluting Endotracheal Tubes for Preventing Bacterial Induced Subglottic Stenosis, Matthew Aronson1, Riccardo Gottardi, PhD1,2,3,4,1University of Pennsylvania, Philadelphia, PA, USA, 2Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 3Children's Hospital of Philadelphia, Philadelphia, PA, USA, 4Ri.MED Foundation, Palermo, Italy

308. Augmentation of Oral Immunotherapy with Tolerance-induce Nanoparticles, Rian Harriman, Hamilton Kakwere, Kenneth Alvarez, Svetlana Miakicheva, Bahieh Noorafkan, Jamal Lewis, University of California, Davis, Davis, CA, USA

309. Highly Adhesive Coatings on Orthopedic Pins to Prevent Infection, Mikhail Bredikhin1, Christopher Gross2, Igor Luzinov1, Alexey Vertegel1, 1Clemson University, Clemson, SC, USA, 2Medical University of South Carolina, Charleston, SC, USA

310. A Dual-Responsive Nanoparticle for Treating Antimicrobial Resistant Infections, Mingzhou Ye1, Yi Zhao1, Yuyuan Wang1, Miao Zhao2, Nisakorn Yodsanit1, Ruosen Xie1, David Andes2, Shaoqin Gong1, 1University of Wisconsin-Madison, Madison, WI, USA, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

311. Microparticle-based delivery of bacteriophage to treat Staphylococcus aureus and Pseudomonas aeruginosa co-infections. . . . . "Pranav Kalelkar, PhD1, Milan Riddick1, Dina Moustafa, PhD2, Joanna Goldberg, PhD2, Nael McCarty, PhD2, Andres Garcia, PhD1, 1Georgia Institute of Technology, Atlanta, GA, USA, 2Emory University, Atlanta, GA, USA

Drug Delivery SIG

312. Repurposing Biodegradable Tissue Engineering Scaffolds For Localized Chemotherapeutic Delivery, Erika Cyphert1,2, Monika Bil, PhD2, Horst von Recum, PhD1, Wojciech Święszkowski, PhD2, 1Case Western Reserve University, Cleveland, OH, USA, 2Warsaw University of Technology, Warsaw, Poland

313. Combinatorial Drug Formulation with Random Heteropolymers Prepared by Polymer Automation, Rahul Upadhya1, Ashish Punia, PhD2, Mythili Kanagala1, Lina Liu, PhD2, Timothy Rhodes, PhD2, Matthew Lamm, PhD2, Adam Gormley, PhD1, 1Rutgers, the State University of New Jersey, Piscataway, NJ, USA, 2Merck & Co., Inc., Rahway, NJ, USA

314. Effects of Particle Size and Surface Functionalization on the Association of Nanoparticles with Human Colon Cancer Cells, Feipeng Yang, PhD1,2, Maleen Cabe, MS1,2, Hope Nowak2,3, Kelly Langert, PhD1,2, 1Loyola University Chicago, Maywood, IL, USA, 2Edward Hines, Jr., VA Hospital, Hines, IL, USA, 3Grinnell College, Grinnell, IA, USA

315. Polymeric Nanoparticle Depots for Controlled and Sustained Gene Delivery, Xiaoyang Xu, PhD, Zhongyu Li, New Jersey Institute of Technology, Newark, NJ, USA

317. Ultra-High Viscous Alginate and the Development of Future Cochlear Implants, Verena Scheper, PhD1,2, Jana Schwieger, PhD1,2, Thomas Rau, PhD1,2, Thomas Lenarz, PhD1,2, 1Hannover Medical School, Hannover, Germany, 2German Research Foundation, Hannover, Germany

318. A Novel Fusogenic Peptide Delivery System targeting CSNK2A1 in Ovarian Cancer Cells, Timothy Samec, Jr., MS, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Anexander-Bryant, PhD, Clemson University, Clemson, SC, USA

319. Multifunctional microparticles incorporating gold compound inhibit lung cancer xenograft, John Kao, PhD, Puiyan Le, PhD, CN Lok, PhD, Chi-Ming Che, PhD, University of Hong Kong, Hong Kong, Hong Kong

320. Towards the oral delivery of high isoelectric point therapeutic proteins using poly(acrylamide-co-itaconic acid) nanoparticle carriers, Heidi Oldenkamp1,2, Divya Gupta2,3, Isabel De La Fuente1,2, Avha Mohanty1,2, Nicholas Peppas1,2,3,4,5, 1University of Texas at Austin, McKetta Department of Chemical Engineering, Austin, TX, USA, 2University of Texas at Austin, Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, Austin, TX, USA, 3University of Texas at Austin, Department of Biomedical Engineering, Austin, TX, USA, 4University of Texas at Austin, Department of Surgery and Perioperative Care, Dell Medical School, Austin, TX, USA, 5University of Texas at Austin, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, Austin, TX, USA"

321. A Platform for Macrophage-mediated Delivery of Polymeric Prodrugs to Solid Tumors, Ciana Lopez, BS1,2, Katherine Brempelis, PhD2, James Matthaei, PhD2, Kate Montgomery, PhD1, Selvi Srinivasan, PhD1, Debashish Roy, PhD1, Shannon Kreuser, BS2, John Chiefari, PhD3, Courtney Crane, PhD2, Patrick Stayton, PhD1, 1University of Washington, Seattle, WA, USA, 2Seattle Children’s Research Institute, Seattle, WA, USA, 3CSIRO Manufacturing, Clayton South MDC, Australia

322. RhMG53 delivered by a ROS-scavenging hydrogel promotes diabetic wound healing by regulating STAT3 signaling, HONG NIU, PhD1, Haichang Li, PhD2, Ya Guan, MS1, Jianjie Ma, PhD2, Jianjun Guan, PhD1, 1Washington University in St. Louis, St Louis, MO, USA, 2The Ohio State University, Columbus, OH, USA

323. Temperature-controlled multi-drug releasing with core-shell structured phase change nanoparticles, Qingxuan Li, Ming Su, Northeastern University, Boston, MA, USA

324. Extended Statin-Drug Release from Bioprinted Triple-Networked Hydrogels Composed of Modified Chitosan and PLA-PEG Micelles. . . "Tamanna Ferdous, BS, Naisha Chowdhury, Emily Coleman, Karla Cisneros, Jessica Jennings, PhD, Joel Bumgardner, PhD, Tomoko Fujiwara, PhD, University of Memphis, Memphis, TN, USA

Engineering Cells and Their Microenvironments SIG

325. Phototunable Interpenetrating Polymer Network Hydrogels Stimulate iPSC-EP Vasculogenesis, Cody Crosby, PhD1,2, Alex Hillsley, BS3, Sachin Kumar, PhD2, Sapun Parekh, PhD2, Adrianne Rosales, PhD3, Janet Zoldan, PhD2, 1Southwestern University, Georgetown, TX, USA, 2The University of Texas at Austin, Biomedical Engineering, Austin, TX, USA, 3The University of Texas at Austin, Chemical Engineering, Austin, TX, USA

326. Development of an in vitro dual hydrogel system for studying angiogenesis and vascularization, Sungwoo Kim, PhD, Sien Lin, PhD, MD, Yunzhi Yang, PhD, Stanford University, Palo Alto, CA, USA

327. Modulating Wound Healing Parameters via Tri-layered, Multiphasic Dressing for Diabetic Foot Ulcers, Elizabeth Gianino, Jordon Gilmore, PhD, Clemson University, Clemson, SC, USA

329. Dermal Full Thickness Wound Healing: Equine Amniotic Membrane Versus Commercially Available Xenografts, Ryanne Early, MS1, Rachel Depa1, Harold Aberman, DVM, MSE1,2, 1Seed Biotech, Inc., Dallas, TX, USA, 2Purdue University, Sewalls Point, FL, USA

330. Engineering a Synthetic Macroencapsulation Device for the Treatment of Type One Diabetes, Michelle Quizon, BS1, Graham Barber, BS1, Cherie Stabler, PhD2, Andrés García, PhD1, 1Georgia Institute of Technology, Atlanta, GA, USA, 2University of Florida, Gainesville, FL, FL, USA

331. Functionalized PLGA Scaffolds Embedded with Mesenchymal Stem Cell-encapsulated Alginate Hydrogel Microspheres for Tissue Regeneration, Min Wang, PhD, Huihua Li, Li-wu Zheng, PhD, The University of Hong Kong, Hong Kong, Hong Kong

332. Control of Fibroblast Differentiation in Acoustically-Responsive Scaffolds using Ultrasound-Induced Matrix Stiffening, Easton Farrell, Mitra Aliabouzar, Carole Quesada, Brendon Baker, Andrew Putnam, Renny Franceschi, Mario Fabiilli, University of Michigan, Ann Arbor, MI, USA

333. Novel Longer Lasting Crosslinked Hyaluronic Acid-Based Gel for Use As A Dermal Filler, David Gravett, PhD, Bethany Acampora, PhD, David Evans, Joel Corbett, PhD, Hafiz Busari, Poly-Med, Inc., Anderson, SC, USA

334. A Dual Crosslinkable Bioink for 3D Printing of Scaffolds Towards Wound Healing, Marzieh Monfared, PhD, Damia Mawad, Jelena Rnjak-Kovacina, Martina Stenzel, University of New South Wales (UNSW), Sydney, Australia

335. Silk fibroin nanofibers containing chondroitin sulfate and silver sulfadiazine for wound healing treatment, Edvani Muniz, PhD1,2, Marilia CestariPhD, PhD1, Bárbara Caldas, PhD1, Dyenefer Fonseca1, Rodolfo Balbinot1, Danielle Lazarin-Bidóia1, Issei Otsuka, PhD3, Celso Nakamura1, Redouane Borsali, PhD3, 1Maringa State University, Maringa, Brazil, 2Federal University of Piaui, Teresina, Brazil, 3University of Grenoble Alpes, Grenoble, France

336. Mechanical Properties of Chitosan/Starch/Jatropha dioca Composites for Skin Engineering, Diego Olivares-Ochoa, BS1, Amanda Carrillo-Castillo1, Monica-Elvira Mendoza-Duarte1, Santos-Adriana Martel-Estrada2, 1Universidad Autónoma de Ciudad Juárez/IIT, Ciudad Juarez, Mexico, 2Universidad Autónoma de Ciudad Juárez/IADA, Ciudad Juarez, Mexico

337. Microscopic Local Stiffening in Supramolecular Hydrogel Network Expedites Stem Cell Mechanosensing in 3D, Weihao Yuan1, Haixing Wang2, Chao Fang, PhD3, Yongkang Yang2, Xingyu Xia3, Yuan Lin, PhD3, Gang Li, PhD2, Liming Bian, PhD1, 1The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 3The University of Hong Kong, Hong Kong, Hong Kong

338. One-step Harvest and Delivery of Honeycomb-shaped Microtissues Using Temperature-responsive Hydrogel, Se-jeong Kim1,2, Heungsoo Shin, PhD1,2, 1Hanyang University, Seoul, Republic of Korea, 2BK21 FOUR, Education and Research Group for Biopharmaceutical Innovation Leader, Seoul, Republic of Korea

339. Bacterial Derived Cellulose with Tunable Optical Clarity for Wound Dressing Applications "Elizabeth van Zyl, Jeannine Coburn, PhD, Worcester Polytechnic Institute, Worcester, MA, USA

340. Synergistic Effect of Placental Membrane Extract and Hypoxia on Human Adipocyte Differentiation, Alejandro Magana, B.S1, Regina Giovanni1, Mathew Mathew, PhD1, Sarah Hagarty, MD2, Divya Bijukumar, PhD1, Mrignayani Kotecha3, 1University of Illinois at Chicago, Rockford, IL, USA, 2OSF Medical Center, Rockford, IL, USA, 302M Technologies, LCC, Chicago, IL, USA

341. Investigation of UV Curing of Diazirine-grafted Bioadhesives at Elevated Temperature, Elwin Ang, Bachelor of Engineering (Materials Engineering), Terry Steele, PhD, Nanyang Technological University, Singapore, Singapore

Orthopaedic Biomaterials SIG

342. Single Micro-Asperity Fretting Corrosion of CoCrMo, Ti6Al4V, and 316 Stainless Steel, Annsley Mace, Jeremy Gilbert, PhD, Clemson University, Clemson, SC, USA

344. Does microstructure influence the corrosion behavior of Ti-6Al-4V orthopedic implants?, Mozart Neto, PhD1, Simona Radice, PhD1, Deborah Hall, Bsc1, Joshua Jacobs, Md1, Mathew Mathew, PhD2, Robin Pourzal, PhD1, 1Rush University Medical Center, Chicago, IL, USA, 2University of Illinois Medical College, Rockford, IL, USA

345. Impacts of Conditioned Medium on Tenocyte and Fibroblast Growth Within Porous Titanium Scaffolds, Paula Dietz1, Therese Bou-Akl, PhD1,2, Rishi Chatterji1, Joseph Seta1, Weiping Ren, PhD1,2, David Markel1,2, 1Ascension Providence Hospital, Southfield, MI, USA, 2Wayne State University, Detroit, MI, USA

346. Systematic Analysis of Corrosion, Wear Debris, Compositional Changes, and Physical Properties of Explanted Magnetically Controlled Growing Rods. . "Basel Khader, PhD, Karl Jepsen, PhD, Ying Li, PhD, University of Michigan, Ann Arbor, MI, USA

347. Drug-Free antibacterial activity of Silver-Releasing Bioactive Glass Nanoparticles for Bone Regeneration, Natalia Pajares-Chamorro1, Sandra Hernández-Escobar1, Yadav Wagley, PhD2, Neal Hammer, PhD1, Parker Acevedo2, Kurt Hankenson, DVM, PhD2, Xanthippi Chatzistavrou, PhD1, 1Michigan State University, Lansing, MI, USA, 2University of Michigan, Ann Arbor, MI, USA

348. CoCrMo Alloy Features Affecting Material Loss in Severely Damaged THA Femoral Head Tapers, Stephanie McCarthy, Mozart Queiroz Neto, PhD, Mable Je, Deborah Hall, Joshua Jacobs, MD, Robin Pourzal, PhD, Rush University Medical Center, Chicago, IL, USA

349. Substituted Apatites as Regenerative Bone Scaffolding. . "Clark Nielson1,2, Sujee Jeyapalina, PhD1,2, Jill Shea, PhD1,2, James Beck, PhD1,2, 1University of Utah, Salt Lake City, UT, USA, 2Department of Veterans Affairs, Salt Lake City, UT, USA

350. Abrasion properties of Ti6Al4V additively manufactured porous structure and the impact of blasting, Mahdieh Aghazadeh, PhD, Yuwei Zhai, PhD, Timothy Gunther, Weidong Tong, PhD, DePuy Synthes, Warsaw, IN, USA

351. Effect of Build Orientation on Strut-to-Substrate Weld Areas in Additively Manufactured Porous Coatings, Yuwei Zhai, PhD, Brett English, Rakshak Nemiraj, Weidong Tong, PhD, DePuy Synthes, Warsaw, IN, USA

352. Bioactive Alterations to Mineralized Collagen Scaffolds to Enhance Craniofacial Bone Repair, Aleczandria Tiffany1, Marley Dewey1, Danielle Gray, PhD1, Toby Woods, PhD1, Kiran Subedi, PhD2, Brendan Harley, PhD1, 1University of Illinois at Urbana-Champaign, Champaign, IL, USA, 2North Carolina A&T, Greensboro, NC, USA"

353. A Comparative Study to Assess the Osteogenic Potential of Different Bioceramics for Bone Tissue Engineering, Nashaita Patrawalla, Nilabh Kajave, Vipuil Kishore, Florida Institute of Technology, Melbourne, FL, USA

354. Multifunctional Fullerene Biocatalyst for Regenerative Application, Gülcihan Gülseren, Faculty of Agriculture and Natural Sciences, Konya, Turkey

355. Variations in Dental Implant Electrochemical Behavior in the Presence of Ti-ions and Ti-particles: A Pilot Study, Mostafa Alhamad, BDS, MS1,2, Valentim Barao3, Cortino Sukotjo1, Lyndon Cooper1, Mathew Mathew, PhD1, 1University of Illinois-Chicago, Chicago, IL, USA, 2Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, 3University of Campinas, Piracicaba, Brazil

356. A Novel Synthesis Method of Carbide Derived Carbon (CDC) Surface Modification for Hip Implants, Yani Sun1, Kai-yuan Cheng, PhD2, Mathew Mathew, PhD1,2, Michael McNallan, PhD1, 1University of Illinois at Chicago, Chicago, IL, USA, 2Univerisity of Illinois College of Medicine at Rockford, Rockford, IL, USA

357. Machine learning guided biomaterials development, Ying Mei, PhD1, Sophia Silver1, Jianjun Hu, PhD2, 1Clemson University, Charleston, SC, USA, 2University of South Carolina, Columbia, SC, USA

358. Metformin improves chondrogenic potential of infrapatellar fat pad derived mesenchymal stem cells in an inflammatory microenvironment, SUGATA HAZRA, PhD, KASHISH JAIN, DHIRENDRA KATTI, PhD, Indian Institute of Technology- Kanpur, Kanpur, India, Biomaterials for Regenerative Engineering

Biomaterials for Regenerative Engineering

359. Biodegradable piezoelectric scaffold for cartilage regeneration, Yang Liu, PhD, Thanh Nguyen, PhD, University of Connecticut, Storrs, CT, USA

360. Resorbable Composite Polymer Ceramic Scaffolds Support Bone Growth and Bonding In Vivo, Gerardo Figueroa, David Gonzales, Efren Barron Villalobos, Luis Arciniaga, Douglas Loy, PhD, Krishna Muralidharan, PhD, Barrett Potter, PhD, John Szivek, PhD, David Margolis, PhD, MD, The University of Arizona, Tucson, AZ, USA

361. Estimation of Dual Simvastatin and Raspberry ketone Effect on Macrophage Phenotype and Evaluation of its. Potential Localized Anti-inflammatory Activity from Hexanoic anhydride Treated Chitosan Guided Bone. Regeneration (GBR) membranes, Mallesh Kurakula, PhD1, Richard Smith, PhD2, Joel Bumgardner, PhD1, 1University of Memphis, Memphis, TN, USA, 2University of Tennessee Health Science Center, Memphis, TN, USA

362. Incorporation of Peptide-Modified Chondroitin Sulfate to a Collagen I/II Blend Hydrogel for Cartilage Engineering, Carly Battistoni1, Claire Kilmer, PhD1, Tanaya Walimbe, PhD2, Alyssa Panitch, PhD1,2, Julie Liu, PhD1, 1Purdue University, West Lafayette, IN, USA, 2UC Davis, Davis, CA, USA

363. Development of PolyHIPE Autograft Extenders for Improved Bone Regeneration, Dana Jenkins, MSE1, Elizabeth Cosgriff-Hernandez, PhD1, Dave Laverty2, Brian Saunders3, 1The University of Texas at Austin, Austin, TX, USA, 2University of Texas at Austin, Austin, TX, USA, 3Texas A&M University, College Station, TX, USA

364. Osteoinductive Oxygen Carrying Nanoparticle for Bone Repair, Chung-Sung Lee, PhD, Jiabing Fan, MD, PhD, Tara Aghaloo, DDS, MD, PhD, Min Lee, PhD, University of California Los Angeles, Los Angeles, CA, USA

366. Safety and efficacy studies on silk fibroin-based bone void filler: Serioss® "Rucha Deshpande1, Raeesa Sayyad1, Swati Shukla1, Anuya Nisal2, Premnath Venugopalan2, 1Serigen Mediproducts Pvt. Ltd., Pune, India, 2CSIR-National Chemical Laboratory, Pune, India

367. Plant-derived Zein Protein as a Scaffold Material for Cell Growth and Osteogenesis, Apurva Limaye, Treena Livingston Arinzeh, PhD, New Jersey Institute of Technology, Newark, NJ, USA

368. Bilayered, Click Biofunctionalized Hydrogels for Osteochondral Repair, Jason Guo, PhD1, Yu Seon Kim, PhD1, Gerry Koons1, Johnny Lam, PhD2, Sergio Barrios1, Adam Navara1, Virginia Xie1, Emma Watson, PhD1, Brandon Smith, PhD1, Hannah Pearce1, Elysse Orchard, DVM, Jeroen van den Beucken, PhD, John Jansen, DDS, PhD, Antonios Mikos, PhD1, 1Rice University, Houston, TX, USA, 2Food and Drug Administration, Silver Spring, MD, USA

369. Multicellular spheroids incorporating osteoinductive and ROS scavenging synthetic fibers with biomineral coating "Hayeon Byun1,2, Heungsoo Shin1,2, 1Hanyang university, Seoul, Republic of Korea, 2Hanynag university, Seoul, Republic of Korea

370. Biofabrication of spheroids positioned micro-chamber with dual growth factors delivery for bone tissue regeneration, Jinkyu Lee, PhD.1,2, Seung Jae Huh, BS.1,2, Heungsoo Shin, PhD.1,2, 1Hanyang University, Seoul, Republic of Korea, 2BK21 FOUR, Education and Research Group for Biopharmaceutical Innovation Leader, Seoul, Republic of Korea

371. LDH NANOPARTICLE-INTEGRATED SCAFFOLDS FOR BONE TISSUE ENGINEERING APPLICATIONS, Zeynep Akguner, MSc1, Emine Alarcin, PhD2, Erdal Karaoz, PhD3, Ayca Bal Ozturk, PhD4, 1Institute of Health Sciences, Istinye University, Istanbul, Turkey, 2Faculty of Pharmacy, Marmara University, Istanbul, Turkey, 3School of Medicine, Istinye University, Istanbul, Turkey, 4Faculty of Pharmacy, Istinye University, Istanbul, Turkey

372. Improving the Porosity of the Subchondral Bone Phase of a Multi-Layered Osteochondral Biomaterial, Andrea Vera Martinez, Jeremy Mercuri, PhD, Clemson University, Clemson, SC, USA

373. The Mechanical Modification of a Novel Scaffold to Treat Focal Cartilage Defects "Vishal Thomas, MS1, Alan Marionneaux2, Jeremy Mercuri, PhD1, 1Clemson University, Clemson, SC, USA, 2GE Power, Greenville, SC, USA

Cardiovascular Biomaterials SIG

374. Effect of Topological Structure on Physico-Mechanical and Biological Properties of Surface-modified Magnesium Hydroxides "Dong Keun Han1, Eun Young Kang1, Seung-Woon Baek1, Yun Heo1, Chun Gwon Park2, 1CHA University, Seongnam-si, Republic of Korea, 2Sungkyunkwan University, Suwon-si, Republic of Korea

375. Optimization of Decellularization Methods in Blood Vessel Tissue Engineering, Bethany Lefeber, Dan Simionescu, Agneta Simionescu, Clemson University, Clemson, SC, USA

376. Mitral Valve Tissue Engineering for Mitral Valve Prolapse Prevention, Collin Owens, Agneta Simionescu, PhD, Clemson University, Clemson, SC, USA

377. Validation of a High-Throughput Bioreactor for Cardiac Tissue Modeling, Howard Herbert, IV, Agneta Simionescu, PhD, Clemson University, Clemson, SC, USA

378. Immobilization of a Collagen-mimicking Peptide to the Surface of Poly(vinyl alcohol) Hydrogels Promotes Endothelialization While Minimizing Thrombosis, Heather Heidenreich1, Novella Bates1, Meghan Fallon1, Yuan Yao2, Evelyn Yim, PhD2, Monica Hinds, PhD1, Deirdre Anderson, PhD1, 1Oregon Health & Science Univerisity, Portland, OR, USA, 2University of Waterloo, Waterloo, ON, Canada

379. Wnt and BMP Signaling in Vascular Calcification, Kaylee Bundy, LaShan Simpson Mississippi State University, Mississippi State, MS, USA

380. In vitro Fibrotic Cardiac Tissue through Bioartificial Scaffolds, Alice Zoso, PhD1,2, Gerardina Ruocco1,2, Mattia Spedicati1,2, Irene Carmagnola, PhD1,2, Valeria Chiono1,2, 1Politecnico di Torino, Turin, Italy, 2Interuniversity Center for the Promotion of 3Rs Principles in Didactics and Research - Centro 3R, Pisa, Italy

381. Sirolimus Delivery from an Electrospun Vascular Access Graft Material Jayashree Chakravarty, 1Rayan Kassab, 1Nathaniel Long, 2Nikhil Agrawal, 2Yael Vin, 2Mauricio Contreras, 1Lisa Fitzgerald, 1Matthew Phaneuf, 1 Patrick Hayden
1BioSurfaces, Inc., Ashland, MA; 2B.I. Deaconess Medical Center, Boston, MA

382. Using Design of Experiment (DOE) to Establish Repeatable In Vitro Accelerated Use Model for Thrombogenicity, James Freasier, BD Medical, Salt Lake City, UT, USA

383. Optical Coherence Tomography for Assessing the Blood Flow Patterns in Coronary Artery Bypass Grafts, Reece Fratus, Junkai Yang, Siyu Ma, PhD, Lucas Schmidt, PhD, Thomas Fair, Bruce Gao, PhD, Clemson University, Clemson, SC, USA

384. Reduced Thrombogenicity of Syndecan-4 Functionalized Engineered Vascular Biomaterial, Yidi Wu1,2, William Wagner1,2, 1Wake Forest University School of Medicine, Winston-Salem, NC, USA, 2Virginia Tech - Wake Forest University, Winston-Salem, NC, USA

385. Dosage and Biodistribution of Drug Loaded Nanogels in Disseminated Intravascular Coagulation, Emily Mihalko1,2, Nina Moiseiwitsch1,2, Ashley Brown1,2, 1North Carolina State University and the University of North Carolina at Chapel-Hill, Raleigh, NC, USA, 2North Carolina State University, Raleigh, NC, USA

386. Electrospun Scaffolds with Electroconductive Carbon Nanotubes for Cardiac Tissue Engineering Applications, Taylor Suh, Jessica Gluck, PhD, North Carolina State University, Raleigh, NC, USA

387. Does a Conductive Scaffold with Polyaniline Improves Ventricular Remodeling. When Incorporated to a Dense Lamellar Collagen Cardiac Patch?, Fernanda Leite, MS1, Juliana Marana2, Luiza de Sá2, Daniela Carvalho, PhD2, Denise Grotto, PhD1,2, Marcus Chaud, PhD1, Lindemberg Silveira-Filho, MD, PhD2, 1University of Sorocaba, Sorocaba, Brazil, 2University of Campinas, Campinas, Brazil

388. Design of Hydrogel Coatings of Electrospun Vascular Grafts via Diffusion-Mediated Redox Polymerization, Megan Wancura1, Andrew Robinson2, Elizabeth Cosgriff-Hernandez, PhD2, 1University of Texas at Austin, Austin, TX, USA, 2The University of Texas at Austin, Austin, TX, USA

Immune Engineering SIG

389. Textile/Hydrogel Composite Vascular Graft Attenuates Inflammatory Macrophage Response while Ameliorating Mechanical Performance. . "Fan Zhang1, Ozan Akkus, PhD2, Mani Daneshmand3, Martin King1,4, 1North Carolina State University, Raleigh, NC, USA, 2Case Western Reserve University, Cleveland, OH, USA, 3Emory University, Atlanta, GA, USA, 4Donghua University, Shanghai, China

390. Physiological polyanions, interacting with the SARS-CoV-2 virus-cell-docking machinery, Werner Müller, Dr., Xiaohong Wang, Dr. University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

391. Inhibition of Glycolysis in the Presence of Self-Antigen Generates Suppressive Antigen-Specific Responses and Restrains Autoimmunity, Joslyn Mangal1, Sahil Inamdar1, Xiaojin Shi1, Marion Curtis, PhD2, Haiwei Gu, PhD1, Abhinav Acharya, PhD1, 1Arizona State University, Tempe, AZ, USA, 2Mayo Clinic, Scottsdale, AZ, USA

392. Supramolecular Nanomolecules Abrogate Inflammation In A Mouse Model Of Ulcerative Colitis, Matthew Bury, MS, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

393. Tunable Lipid-Polymer Nanoparticles for Anti-Inflammatory Polarization of Macrophages, Elizabeth Bender, Laura Suggs, PhD, The University of Texas at Austin, Austin, TX, USA

394. Alginate Instigates Adjuvant Effects on Indirect Antigen Recognition and T Cell Activation for Encapsulated Cell Therapies, Ying Li1, Anthony Frei, PhD1, Allison Bayer, PhD2, Cherie Stabler, PhD1, 1University of Florida, Gainesville, FL, USA, 2University of Miami, Miami, FL, USA

395. Co-assembled peptide nanoparticles for enzyme delivery, Renjie Liu, PhD, Gregory Hudalla, PhD, University of Florida J. Crayton Pruitt Family, Gainesville, FL, USA

396. Synthesis and immune-compatibility evaluation of degradable polystyrene analogue, HONG ANH TRUONG, PhD1, Srinivasa Reddy Mothe, PhD2, Alexander William Jackson, Ph.D2, Parijat Kanaujia, PhD2, Jaclyn Lee Min, BEng1, Hui Min Tan, BEng1, Dang Tri Nguyen, MEng1, Danson Kwong Jia Ye, BEng1, Praveen Thoniyot, PhD2, TRAM THUY DANG, PhD1, 1Nanyang Technological University, Singapore, Singapore, 2Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

397. Secretome-loaded Plasma-alginate Composite Gels Modulate the Inflammatory Response In vitro, Marc Thompson, PhD, Shanmugasundaram Natesan, PhD, Robert Christy, PhD, US Army Institute of Surgical Research, San Antonio, TX, USA

398. Engineered exosomes for immunomodulatory therapy in type 1 diabetes, Matthew Becker1, Leeana Peters2, Todd Brusko, PhD2, Edward Phelps, PhD1, 1University of Florida, Gainesville, FL, USA, 2University of Florida Diabetes Institute, Gainesville, FL, USA

399. Intravascular Infusible Extracellular Matrix for the Mitigation of Severe Systemic Inflammation Relevant to. COVID-19 Pathology, Raymond Wang, PhD1, Anne Lyons1, Ryan Middleton, PhD1, Mark Hepokoski, MD2, Karen Christman, PhD1, 1University of California San Diego, La Jolla, CA, USA, 2University of California San Diego Vc-Health Sciences, La Jolla, CA, USA

400. 3D Printed Barrier Construct for Bone Engineering In Systemic Inflammatory Conditions, Zeena Qiryaqoz1, Robert Swenson2, Liu Hong2, Kim Brogden2, Adil Akkouch1, 1Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA, 2Iowa Institute for Oral Health Research, Iowa City,, IA, USA

Drug Delivery SIG

401. Ultrasound-Mediated Drug Release from Pegylated and Targeted Liposomes, Nahid Awad, OHD1, VInod Paul1, Mohammad Mahmound, MS- CHE1, Nour AlSawaftah, MS- CHE1, Paul Kawak, MS-CHE1, Mohammad AlSayah, PhD2, Ghaleb Husseini, PhD1, 1American University of Sharjah, Sharjah, United Arab Emirates, 2AUS, Sharjah, United Arab Emirates

402. Ultrasound-Mediated Drug Release from Transferrin-PEG Liposomes, Ghaleb Husseini1, Nour AlSawaftah1, Nahid Awad1, Vinod Paul1, Paul Kawak1, Mohammad AlSayah2, 1American University of Sharjah, Sharjah, United Arab Emirates, 2AUS, Sharjah, United Arab Emirates

403. Drug Release from Pegylated and Targeted Liposomes Using High-frequency Ultrasound, Ghaleb Husseini, Nour AlSwaftah, Vinod Paul, American University of Sharjah, Sharjah, United Arab Emirates

404. Ultrasound mediated release from hyaluronic acid targeted liposomes, Ghaleb Husseini1, Safa Ben Daya1, Nahid Awad1, Vinod Paul1, Mohammad Alsayah2, 1American University of Sharjah, Sharjah, United Arab Emirates, 2American Univeristy of Sharjah, Sharjah, United Arab Emirates

405. In Vitro Cell Work of Two Types of Targeted Nanoparticles with Ultrasound Triggering, Ghaleb Husseini, Waad Abu Watfa, Debasmita Mukhopadhyay, Nour Alsawaftah, American University of Sharjah, Sharjah, United Arab Emirates

406. Magnetically-Responsive Shape Memory Polymers for Drug Delivery, Anand Vakil, Mary Beth Monroe, PhD, Syracuse University, Syracsue, NY, USA

407. Light-Triggered Immune Activation by Photolabile PEG-Modified Cytokines, Lacey Perdue1, Priscilla Do, PhD1, Khalid Salaita, PhD1, Gregory Lesinski, PhD, MPH2, Christopher Porter, MD2,3, Erik Dreaden, PhD1,2,3, 1Georgia Institute of Technology and Emory University, Atlanta, GA, USA, 2Winship Cancer Institute of Emory University, Atlanta, GA, USA, 3Emory School of Medicine, Atlanta, GA, USA

408. Ultrasound Sensitive Microbubbles with Carbon Monoxide for Delivery to Blood Brain Barrier, Jennifer VanSant, Shirin Changizi, Isabel Marquette, Osamah Alghazwat, Mahyar Sameti, PhD, Yi Liao, PhD, Chris Bashur, PhD, Florida Institute of Technology, Melbourne, FL, USA

409. Using Shape to Modulate Biophysical Interactions between Polymersomes and the Blood-Brain Barrier, Christopher Pierce, Jessica Larsen, PhD, Clemson University, Clemson, SC, USA

410. Charge-based targeting of the inflamed colon mucosa in inflammatory bowel disease (IBD) using polymer-drug complexes, Chaitanya Valiveti, M.S1, Rizwan Ahmad, PhD2, Balawant Kumar2, Amar Singh, PhD2, Hemachand Tummala, PhD1, 1South Dakota State University, Brookings, SD, USA, 2University of Nebraska Medical Center, Omaha, NE, USA

411. Curcumin and Silver Nanoparticles incorporated in Polyelectrolyte Complexes aiming Metal Enhanced Singlet Oxygen Generation Effect to Photodynamic Therapy, Edvani Muniz, PhD1,2, Camila de Freitas1, Adley Rubira, PhD1, Elza Kimura, PhD1, 1Maringa State University, Maringa, Brazil, 2Federal University of Piaui, Teresina, Brazil

412. Thermo-reversible Hydrogels as Injectable Localized Protein Delivery System for Applications in Central Nervous System, Tuan Nguyen, PhD1, Chao Pan, PhD1,2, Leon Teo3, Mischa Mueller1, James Bourne3, Timothy Hughes1, Johan Basuki1, 1The Commonwealth Scientific and Industrial Research Organisation (CSIRO), Clayton South, Australia, 2University of Science and Technology of China, Hefei, China, 3Australian Regenerative Medicine Institute, Clayton, Australia

413. A De novo Fibrin-specific Binding Peptide for Bioimaging and Drug Delivery Applications. "Yoon Sung Nam, PhD, Moon Young Yang, PhD, Jeong Heon Yu, PhD, Korea Advanced Institute of Science and Engineering, Daejeon, Republic of Korea

414. A Mineral-Coated Microparticle Delivery System for Interleukin-15, Hannah Martin, Joshua Choe, William Murphy, PhD, University of Wisconsin-Madison, Madison, WI, USA

Translating Biomaterials Research: Accelerating Bench to Bedside *BTI*

415. Tissue-Engineered Vascular Graft of Small Diameter Using Human Amnion Membrane, Bo Wang, Professor, Medical college of Wisconsin, Wauwatosa, WI, USA

416. Cardiac Function Restoration by Co-Delivery of 5-Azacytidine in Protein Nanoparticles for Effective Stem Cell Differentiation in Rat Myocardial Infarction, Vineeta Sharma, M.Sc1, Sanat Dash, M. Tech1, Amit Manhas, PhD2, Janani Radhakrishnan, PhD1, Kumaravelu Jagavelu, PhD2, Rama Verma, PhD1, 1Indian Institute Of Technology, Chennai, India, 2CSIR- Central Drug Research Institute, Lucknow, India

417. Human-Derived 3D Microvessels to Study Pulmonary Vascular Barrier Function, Crescentia Cho1,2, Elizabeth Doherty1,2, Leigh-Ann Antczak3, Rebecca Heise, PhD3, William Polacheck, PhD1,2, 1University of North Carolina Chapel Hill, Chapel Hill, NC, USA, 2North Carolina State University, Raleigh, NC, USA, 3Virginia Commonwealth University, Richmond, VA, USA

418. Conductive Aerogel for Skeletal Muscle Repair, Malcolm Xing, University of Manitoba, Winnipeg, MB, Canada

419. Micropatterned Human Pluripotent Stem Cells Enable Modeling of the Earliest Developmental Stages of Cardiac Vascularization. "Oscar Abilez, MD, PhD1, Huaxiao Yang, PhD1,2, Kitchener Wilson, MD, PhD1, Lei Tian, PhD1, Yan Zhuge, PhD1, Fangjun Jia, PhD1, Hung-Ta Wo, MD1, Bryan Aldana, BS1, Christopher Zarins, MD1, Joseph Wu, MD, PhD1, 1Stanford University, Stanford, CA, USA, 2University of North Texas, Denton, TX, USA

420. Aortic Adventitia-Derived Extracellular Matrix Hydrogel Enhances Contractility of Pericytes, Kaitlyn Wintruba1, Jennifer Hill1, Tara Richards1, Marie Billaud2, Thomas Gleason2, Julie Phillippi1, 1University of Pittsburgh, Pittsburgh, PA, USA, 2Brigham and Women's Hospital, Boston, MA, USA

421. Engineered Human induced pluripotent stem cell Derived Four-lineage Cardiac Muscle Patch For Myocardial Repair, Xi Lou, Danielle Pretorius, Asher Kahn-Krell, Vladimir Fast, Ph.D., Jianyi Zhang, M.D., Ph.D., University of Alabama at Birmingham, Birmingham, AL, USA

422. Translating Biomedical Technologies from Bench to Bedside: Asia Perspective and Opportunity, John Kao, PhD, Hong Kong Science and Technology Park, Hong Kong, Hong Kong

423. Translating Porous and Bioactive PEEK to Interbody Spinal Fusions Implants: Patience is a Virtue in the Journey from Bench to Bedside. "Ryan Roeder1,2, James Nagle1, Doug Snell2, 1University of Notre Dame, Notre Dame, IN, USA, 2HAPPE Spine, LLC, Grand Rapids, MI, USA

424. Three-dimensional, label-free cell viability measurements in tissue engineering scaffolds using optical coherence tomography, Greta Babakhanova, PhD1, Deepika Arora, PhD1, Allison Horenberg1, Jagat Budhathoki, PhD2, Joy Dunkers1, Joe Chalfoun, PhD1, Peter Bajcsy, PhD1, Anant Agrawal, PhD3, Carl Simon, Jr., PhD1, 1National Institute of Standards and Technology, Gaithersburg, MD, USA, 2National Institutes of Health, Bethesda, MD, USA, 3Food and Drug Administration, Silver Spring, MD, USA

425. Modified Polylactide with Increased Toughness for Orthopedic Implants "M Scott Taylor, PhD, Brian Gaerke, Parimal Patel, Sydney Nuckles, Seth McCullen, PhD, Poly-Med, Inc., Anderson, SC, USA

426. An Engineered Dry Powder Dispersion Device for In Situ Tissue Sealant Application, Rachael Oldinski-Floreani, PhD, Patrick Charron, MS, James Reilly, MS, University of Vermont, Burlington, VT, USA

427. Anisotropic Nanofibrillar Scaffolds Enhance the Survival of Induced Pluripotent Stem Cell-Derived Endothelial Cells for Treatment of Peripheral Arterial Disease, Guang Yang, PhD1, Cynthia Alcazar, BS2, Caroline Hu, BS2, Tatiana Zaitseva, PhD3, Michael Paukshto, PhD3, Ngan Huang, PhD1,2, 1Stanford University, Stanford, CA, USA, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA, 3Fibralign Corporation, Union City, CA, USA

Orthopaedic Biomaterials SIG

428. Biodegradable nanofiber bone-tissue scaffold as remotely-controlled and self-powered electrical stimulator, Ritopa Das, Thanh Nguyen, University of Connecticut, Storrs, CT, USA

429. Engineering porous assembled microgel scaffolds to increase rat mesenchymal stromal cell secretome for bone regeneration applications "Varsha Rao1,2, Samantha Wojda, PhD3, Cole Ferreira3, Alexander Caldwell, PhD1,2, Seth Donahue, PhD3, Kristi Anseth, PhD1,2, 1University of Colorado Boulder, Boulder, CO, USA, 2BioFrontiers Institute, Boulder, CO, USA, 3University of Massachusetts Amherst, Amherst, MA, USA

430. Surface features of 3D-printed bone ingrowth lattices to tailor coefficient of friction, Robert Kane, PhD, Steve Leisinger, Weidong Tong, PhD, DePuy Synthes, Warsaw, IN, USA

431. Evaluation of Raspberry Ketone, a Natural Antioxidant, on Bone Cell Differentiation, Matthew Atwill, Joel Bumgardner, PhD, The University of Memphis, Memphis, TN, USA

432. Biopolymeric Hydrogel Delivered Recombinant BMP-9 versus BMP-2 Mediated Rat Calvarial Bone Defect Healing, Angshuman Bharadwaz, MS1, Bipin Gaihre, PhD2, Janitha Unagolla, MSc.1, Ambalangodage Jayasuriya, PhD3,1The University of Toledo-Main Campus, Toledo, OH, USA, 2Mayo Clinic, Rochester, MN, USA, 3The University of Toledo - Health Science Campus, Toledo, OH, USA

433. Ultra-Stiff and Strong Electrostatic, Poly(N-isopropylacrylamide) Triple Network Hydrogels for Orthopedic Tissue Replacement, Connor Demott, McKenzie Jones, Melissa Grunlan, PhD, Texas A&M University, College Station, TX, USA

434. Biodegradable Shape Memory Polymer (SMP) Bone Scaffolds with Improved Self-Fitting Properties, Michaela Pfau, Kelly McKinzey, Abigail Roth, Lance Graul, Duncan Maitland, PhD, Melissa Grunlan, PhD, Texas A&M, College Station, TX, USA

435. A Flipped Ester group design based methacrylate macromer for improved stability under hydrolytic and enzymatic conditions, Dhiraj Kumar, PhD1, Debarati Ghose, PhD1, Robert Bolskar, PhD2, Isha Mutreja, PhD1, Conrado Aparicio, PhD1, Robert Jones, PhD DDS1, 1University of Minnesota, Minneapolis, MN, USA, 2TDA Research, Inc., Wheat Ridge, CO, USA

436. Biodegradable Polyurethane/Reduced Graphene Oxide Fibers for C2C12 Growth "Alan Taylor, Jiazhu Xu, Huikang Fu, Sara McMahan, PhD, Jun Liao, PhD, Yi Hong, PhD, University of Texas at Arlington, Arlington, TX, USA

437. Micro-CT and Histological Evaluation of a Tissue Engineered Enthesis in a Rat Model: Comparison to Native Tissue, Carla Mayer1, Sebastian Müller2, Michael Coenen2, Antonella Motta3, Claudio Migliaresi3, Christopher Evans2, Martijn van Griensven1,2,4, Elizabeth Balmayor1,2,4, 1Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Mayo Clinic, Rochester, MN, USA, 3BIOtech Research Center and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Trento, Mattarello, Italy, 4MERLN Institute, Maastricht University, Maastricht, Netherlands

438. Evaluating the Validity of an Elastic Modulus Measurement Method for Polymeric Materials, Megha Satpathy, B.Tech.1, John Mecholsky, Jr., PhD, FACerS2, Nader Abdulhameed, BDS, MS, PhD3, Jason Griggs, PhD, FADM1, 1The University of Mississippi Medical Center, Jackson, MS, USA, 2University of Florida, Gainesville, FL, USA, 3Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA

439. Biological and Biomechanical Investigation of Recombinant Human Insulin-like Growth Factor-1 and its Biotherapeutic Delivery in Rotator Cuff Repair, Anupama Prabhath1,2, Caldon Esdaille1, Varadraj Vernekar, Ph.D.1, Amir Lebaschi, M.D.1, Tannin Schmidt, Ph.D.2, Stavros Thomopoulos, Ph.D.3, Nathaniel Dyment, Ph.D.4, Alix Deymier, Ph.D.2, Eckhard Weber, Ph.D.5, Cato Laurencin, M.D., Ph.D.1,2, 1UConn Health, Farmington, CT, USA, 2University of Connecticut, Farmington, CT, USA, 3Columbia University, New York, NY, USA, 4University of Pennsylvania, Philadelphia, PA, USA, 5Novartis Institute for BioMedical Research, Basel, Switzerland

440. Biomineral Coating Enhances Performance of PEEK Implants, Leena Jongpaiboonkit, PhD, Medtronic, Sterling, MA, USA

Engineering Cells and Their Microenvironments SIG

441. Sericin-based gadolinium nanoparticles as synergistically enhancing contrast agents for. pH-responsive and tumor targeting magnetic resonance imaging, Zixuan Huang, B.S.Med1, Yejing Wang, PhD1, Jun Wu2, Huawei He1, Qingyou Xia1, 1Southwest University, Chongqing, China, 2North Sichuan Medical College, Chengdu, China

442. Orthopedic Cements as Carriers of Doxorubicin for Local Chemotherapy Treatment, Grahmm Funk, BS, BS1, Elizabeth Menuey, PhD2, Zachary Denton, BS1, Dalan Pittz, BS1, Kathleen Kilway, PhD2, Terence McIff, PhD, MBA1, 1University of Kansas Medical Center, Kansas City, KS, USA, 2University of Missouri-Kansas City, Kansas City, MO, USA

443. Mimicking Pancreatic Tumor Microenvironment via Sequential Click Reactions, Chun-YI Chang1, Chien-Chi Lin, PhD1,2,3, 1Purdue University, West Lafayette, IN, USA, 2Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA, 3Indiana University-Purdue University Indianapolis, Indianapoils, IN, USA

444. Dendritic Cells Perform Vomocytosis of Cryptococcus neoformans, Noah Pacifici, Melissa Cruz-Acuña, PhD, Neeraj Senthil, Jamal Lewis, PhD, University of California, Davis, Davis, CA, USA

445. Anisotropic-Morphology Nitrodopamine PEGylated Iron Oxide Nanoparticles as Magnetic Actuators for Breast Cancer Treatment, Mahboubeh Nabavinia, PhD, Juan Beltran- Huarac, PhD, East Carolina University, Greenville, NC, USA

446. Evaluating Mechanical Force in the Tumor Microenvironment through Actuating Biomimetic Lung Platform, Sarah Libring1, Angel Enriquez1, Tyler Field2, Julian Jimenez1, Taeksang Lee3, Michael Wendt, PhD4, Sarah Calve, PhD1, Adrian Buganza Tepole, PhD3, Hyowon Lee, PhD1, Luis Solorio, PhD1, 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA, 2Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA, 3Mechanical Engineering, Purdue University, West Lafayette, IN, USA, 4Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA

447. Reversing Tumor Microenvironment Hypoxia with Novel Manganese Dioxide Nanoparticles Improves Natural Killer Cell Response in 3-D Tumor Cell Spheroids, David Murphy, Isaac Adjei, PhD, Heyong Cheng, Xin Yan, PhD, Texas A&M University, College Station, TX, USA

448. Regulatory T Cell Induction in Chronic Lymphocytic Leukemia Patients Manifest Altered Response to Substrate Stiffness Compared to Healthy Individuals, Jee Yoon Lim, Lingting Shi, Lance Kam, PhD, Columbia University, New York, NY, USA

449. The Anti-Tumor Effect of M1 Macrophages on Hepatocellular Carcinoma (HCC), John Kao, PhD1, Alberto Guerra, PhD MD2, Oscar Yeung, PhD1, Kwan Man, PhD1, 1University of Hong Kong, Hong Kong, Hong Kong, 2University of Wisconsin Madison, Madison, WI, USA

450. Altering Macrophage Phenotype to Promote Angiogenesis in Murine Hindlimb Ischemia Model, Gregory Risser1, Dong Li2, Samuel Sung1, Kara Spiller1, 1Drexel University, Philadelphia, PA, USA, 2Shanghai Jiao Tong University School of Medicine, Shanghai, China

451. Characterization of a Self-Assembling Peptide Hydrogel for Delivery of Active Temozolomide in Glioblastoma Treatment, Megan Pitz, Margaret Elpers, Alexandra Nukovic, Sarah Wilde, Angela Alexander-Bryant, Clemson University, Clemson, SC, USA

452. Enabling Complex 3D Cancer-Stroma Co-Cultures with Modular Hydrogels in a High-Throughput Microfluidic Plate, Andrei Bonteanu1, Divya Iyer, PhD2, Peter Shepherd, MSc3, Rick Kittles, PhD4, Nora Navone, MD, PhD3, Dwayne Dexter, PhD2, Kristin Bircsak, PhD2, Daniel Harrington, PhD5, 1Rice University, Houston, TX, USA, 2MIMETAS US Inc, Gaithersburg, MD, USA, 3The University of Texas MD Anderson Cancer Center, Houston, TX, USA, 4City of Hope, Duarte, CA, USA, 5University of Texas Health Science Center at Houston, Houston, TX, USA

453. Hydrogel matrix presence and composition influences drug responses of encapsulated glioblastoma spheroids, Joseph Bruns, Lindsay Hill, PhD, Silviya Zustiak, PhD, Saint Louis University, St. Louis, MO, USA

454. pH-responsive magnesium nanoparticles for targeted gene therapy against mammary carcinoma cells, Veronica Mok, Giselle Chan, Shin Yi Chew, Athirah Bakhtiar, Monash University Malaysia, Bandar Sunway, Malaysia

456. Using the large-scale mining of publicly available immunohistochemical data to uncover the distribution of extracellular matrix proteins in normal and cancerous human tissues, Yun Lam, PhD, Po Lam, Sze Tang, PhD, City University of Hong Kong, Hong Kong, Hong Kong

Tissue Engineering SIG

457. Decoupling the Biophysical Influences of Stiffness and Diffusivity in 3D Encapsulation Hydrogel Scaffolds, Nathan Richbourg, Nicholas Peppas, Sc.D., University of Texas, Austin, TX, USA

458. Facile Synthesis of Rapidly Degrading Poly(ethylene glycol)-based Thiol-Norbornene Hydrogels, Fang-Yi Lin, PhD1, Matthew Arkenberg2, Chien-Chi Lin, PhD1,2, 1Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA, 2Purdue University, West Lafayette, IN, USA

459. 7-Nitroindoline-Based Photocleavable Crosslinkers, Patricio Del Castillo, Philip Baily, Katja Michael, PhD, University of Texas at El Paso, El Paso, TX, USA

460. PEG-HA Dual Networks that Modulate the Secretory Profile of Mesenchymal Stem Cells, Alexandra Borelli, BS, Mark Young, BS, Michael Blatchley, PhD, Varsha Rao, BS, Marissa Wechsler, PhD, Kristi Anseth, PhD, University of Colorado Boulder, Boulder, CO, USA

461. Injectable Alginate Hydrogels loaded with Pleiotrophin enhance Angiogenesis in vivo, Isobel Rountree, Collin Polucha, Kareen Coulombe, Fabiola Munarin, Brown University, Providence, RI, USA

462. A Phase Inversion-based Technique for Fabricating Bicontinuous Porous Scaffolds, Min Wang, PhD, Junzhi Li, MEng, Haoran Sun, The University of Hong Kong, Hong Kong, Hong Kong

463. Modeling Sympathetic Hyperactivity in Alzheimer’s Related Osteopenia, Robert Culibrk, BSE, Ahmad Arabiyat, BSE, Carisa DeKalb, BS, Mariah Hahn, PhD, Rensselaer Polytechnic Institute, Troy, NY, USA

464. Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering, Sangmin Lee, Heungsoo Shin, PhD, Hanyang University, Seoul, Republic of Korea

465. Engineering Protein-based Materials for Scaffold Neovascularization, Gabriela Geraldo Mendes1, David Howell1, Colette Abbey1, Malea Murphy2, Holly Gibbs3, Alvin Yeh3, Kayla Bayless1, Sarah Bondos1, 1Texas A&M Health Science Center, Bryan, TX, USA, 2Texas A&M HSC, Bryan, TX, USA, 3Texas A&M University, College Station, TX, USA

466. Enhanced Granular Hydrogel Properties through Dynamic Covalent Interparticle Crosslinking, Victoria Muir, Jason Burdick, University of Pennsylvania, Philadelphia, PA, USA

467. Leveraging the Chemomechanical Tunability of Silk Fibroin in a Functionally Modular Scaffold Design, Melissa Wojnowski, Jeannine Coburn, PhD, Worcester Polytechnic Institute, Worcester, MA, USA

Bioelectronic Devices & Conducting Biomaterials

468. Interrogating the Relationship Between Hydrogel Electrical and Physical Properties Using a Custom Benchtop Conductivity Setup, Alena Casella1, Alyssa Panitch, PhD1,2, J. Kent Leach, PhD1,2, 1University of California, Davis, Davis, CA, USA, 2UC Davis Health, Sacramento, CA, USA

469. Development and Characterization of an Automated Hydrogel Bioink Preparation Device, Jiannan Li, PhD, Tara Shelby, Hannah Shelby, Yunzhi Peter Yang, Stanford University, Stanford, CA, USA

470. Hybrid Bioprinting via Integrated Additive Manufacturing High-Throughput Acoustic Patterning (IMHAP), Jiannan Li, PhD, Carolyn Kim, Seyedsina Moeinzadeh, PhD, Chi-Chun Pan, PhD, Yunzhi Peter Yang, PhD, Stanford University, Stanford, CA, USA"

471. Norbornene-functionalized methylcellulose as a thermal and photo-responsive bioink, Min Hee Kim, PhD, Chien-Chi Lin, PhD, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

472. Solvent-Cast 3D Printing with Biodegradable Polymers for Tunable Scaffold Properties, John Tolbert1, Diana Hammerstone1, Nathaniel Yuchimiuk2, Lesley Chow1,2, 1Lehigh University, Bethlehem, PA, USA, 2Lehigh Engineering, Bethlehem, PA, USA

473. 3D Electrowriting of GO/PEDOT-DMSO Electroactive Nanocomposite for Bone Engineering Application, Mitchell Kenter, Zeena Qiryaqoz, Adil Akkouch, Western Michigan University. Homer Stryker MD School of Medicine, Kalamazoo,, MI, USA

474. Bioink Optimization and Effects of Microgravity on 3D Printed Cell Laden Constructs, Likitha Somasekhar1, Nicholas Huynh1, Ye Zhang, PhD2, Kenia Nunes, PhD1, Kunal Mitra, PhD1, Vipuil Kishore, PhD1, Chris Bashur, PhD1, 1Florida Institute of Technology, Melbourne, FL, USA, 2NASA, KSC, Cape Canaveral, FL, USA

475. Double Network Hydrogels with Comb Architecture to Achieve Reduced Mesh Sizes, Ping Dong1, Anna Means, PhD2, Bradley Schott1, Gerard Coté, PhD1,3, Melissa Grunlan, PhD1,2,3,4, 1Biomedical Engineering, Texas A&M University, College Station, TX, USA, 2Material Science and Engineering, Texas A&M University, College Station, TX, USA, 3Center for Remote Health Technologies and Systems, Texas A&M University, College Station, TX, USA, 4Chemistry, Texas A&M University, College Station, TX, USA

476. Microfluidic 3D Bioprinting of Cell-Laden Hollow and Core-Shell Fibres, Erin Bedford, Zhensong Xu, Sebastian Steiner, Yoshiaki Tsubota, Rishima Agarwal, Kyle Grode, Spiro Getsios, Simon Beyer, Tamer Mohamed, Sam Wadsworth, Aspect Biosystems, Vancouver, BC, Canada

477. Immobilizing Split GFP Biosensors in Protein Materials: Salt Tunes Analyte Binding and Release, Amanda Jons1, Rebecca Booth, PhD1, Lauren Kustigan, PhD1, Xue Gong1, Hays Rye, PhD1, Shounak Banerjee2, Kacey Kilpatrick2, Chris Bystroff, PhD2, Sarah Bondos, PhD1, 1Texas A&M University, College Station, TX, USA, 2Rensselaer Polytechnic Institute, Troy, NY, USA

478. Shape-morphing Materials for Deployable Intracortical Probes, Rashed Rihani, PhD1, Joseph Pancrazio, PhD1, Taylor Ware, PhD2, Mahjabeen Javed2, 1University of Texas at Dallas, Richardson, TX, USA, 2Texas A&M University, Bryan, TX, USA

479. Immobilization of Antibodies on Solution Blow Spun Mats for Biosensing Applications, Shreya Thammana, Craig Miller, Mark Livingstone, Jordon Gilmore, Clemson University, Clemson, SC, USA

Biomaterials for Women's Health *BTI*

480. 3D-patient derived ovarian tumour model to elucidate biophysical stromal response during high-grade serous ovarian cancer progression, francesca paradiso1,2, stefania lenna1, stefano serpelloni1, francis lewis2, francesca taraballi1,1Houston Methodist Research Institute, houston, TX, USA, 2Swansea University Medical School, swansea, United Kingdom

481. Synthetic Hydrogels Reveal the Role of the Matrix Environment on Sex-Specific Aortic Valve Calcification. and Osteopontin Activity, Megan Schroeder, PhD1, Andrea Gonzalez Rodriguez, PhD1, Kelly Speckl1, Douglas Peters, PhD1, Cierra Walker, MS1, Brian Aguado, PhD1, Joseph Grim, PhD1, Robert Weiss, MD2, Kristi Anseth, PhD1,1University of Colorado Boulder, Boulder, CO, USA, 2University of Iowa, Iowa City, IA, USA

482. Designing a synthetic scaffold to support human folliculogenesis in vivo. "Monica Wall, BS, Hadrian Kinnear, BA, Ariella Shikanov, PhD, University of Michigan, Ann Arbor, MI, USA

483. A 3D Breast Tumor Model to Study the Role of Extracellular Matrix Components on Cancer Cell Invasion, Jacob Heiss, Hossein Tavana, PhD, The University of Akron, Akron, OH, USA

484. Gender-related host factors modulate human craniofacial bone regeneration with bioactive tricalcium phosphate grafts, Christine Knabe, DMD, PhD, Aynur Mele, Peter Kann, MD, PhD, Doaa Adel-Khattab, DDS, PhD, Harald Renz, MD, PhD, Alexander Reuss, MSc, Michael Stiller, MD, DDS, PhD, Philipps University Marburg, Marburg, Germany

485. Extracellular Matrix-Sequestering and Adhesion Peptide Localization Promotes Primordial Follicle Development In Vitro for Fertility Preservation, Claire Tomaszewski1, Daniel Matera2, Brendon Baker, PhD1, Ariella Shikanov, PhD1,3,4, 1University of Michigan, Ann Arbor, MI, USA, 2U of Michigan, Ann Arbor, MI, USA, 3Univ of Michigan, Ann Arbor, MI, USA, 4U Michigan, Ann Arbor, MI, USA

486. Thermosensitive Polyisocyanopeptide Hydrogel for Tissue Regeneration in the Pelvic Floor: An in vitro Study with Vaginal Fibroblasts, Aksel Gudde, PhD1, Melissa van Velthoven, PhD2, Paul Kouwer, Asst Prof2, Jan-Paul Roovers, Prof1, Zeliha Güler Gokce, Post-Doc1, 1Amsterdam University Medical Center, Amsterdam, Netherlands, 2Radboud University, Nijmegen, Netherlands

487. Implantation of human ovarian cortex tissue encapsulated in immune-isolating poly-ethylene glycol-based capsules, Margaret Brunette1, James Day, PhD1, Hadrian Kinnear2,3, Prianka Hashim4, Marilia Cascalho, PhD5,6, Ariella Shikanov, PhD1,2,4, 1University of Michigan, Ann Arbor, MI, USA, 2UMichigan, Ann Arbor, MI, USA, 3U of Michigan, Ann Arbor, MI, USA, 4University of Mich., Ann Arbor, MI, USA, 5U of Mich., Ann Arbor, MI, USA, 6University_of_Michigan, Ann Arbor, MI, USA

488. Engineered Synthetic Matrix-Induced Dormancy in Organotropic Breast Cancer, Cindy Farino, Shantanu Pradhan, PhD, John Slater, PhD, University of Delaware, Newark, DE, USA

BioInterfaces SIG

489. Treatment of Oral Mucositis through Curcumin Poly(beta amino ester) Microparticles, Kelley Wiegman1, Carolyn Jordan2, Brock Howerton2, Zach Hilt1,2, Thomas Dziubla1,2, 1University of Kentucky, Lexington, KY, USA, 2Bluegrass Advanced Materials, Lexington, KY, USA

490. Nanonet-nano fiber electrospun mesh of PCL–chitosan for controlled release of hydrophilic drug "Sheikh Saudi, Jagannathan Sankar, Shyam Aravamudhan, Narayan Bhattarai, North Carolina Agricultural and Technical State University, Greensboro, NC, USA

491. Multifunctional Biomaterial with Antimicrobial and Remineralization Capabilities, Carolina Montoya, Postdoctoral Fellow1, Julia Kurylec1, Santiago Orrego, Assistant Professor1,2, 1Kornberg School of Dentistry, Temple University, Philadelphia, PA, USA, 2College of Engineering, Temple University, Philadelphia, PA, USA

492. Enhanced antibacterial property of Titanium by Nanoscale Modification using Hydrothermal Treatment and surface coating, Vignesh Manivasagam, MS, Ketul Popat, PhD, Colorado State University, Fort Collins, CO, USA

493. Solid Lipid Nanoparticles for Therapeutic Stabilization and Delivery, Melissa Wright1, Victoria Stagnaro1, Kate Johnson1, Jianren Mao, MD, PhD2, Zerong You, PhD2, Christopher Tison, PhD1, Lauren Costella, ME1, 1Luna Innovations Incorporated, Roanoke, VA, USA, 2Massachusetts General Hospital, Boston, MA, USA

494. Examining Intracellular Trafficking of Nucleic Acid Containing Lipid Nanoparticles for Non-Viral Gene Delivery, Christina Bailey-Hytholt, PhD, Gregory Ulinski, Julia Dugas, Peter Piepenhagen, Isidro Zarraga, Amey Bandekar, Sanofi, Framingham, MA, USA

495. Nano-scale Liposomes with Controllable Mechanics for Drug Delivery Applications, Fereshtehsadat Mirab, Dang Dang, Vijay Krishna Raghunathan, Sheereen Majd, University of Houston, Houston, TX, USA

496. Towards Improved Keratitis Treatment: Attachment of Gold Nanoparticles to Bacteria and Nanoparticle Penetration in Corneas, Brooke Bednarke1, Kyle Reeser, PhD2, Daniel Eversole, PhD3, Seth Pantanelli, MD4, Amber Doiron, PhD5, 1University of Vermont, Burlington, VT, USA, 2Binghamton University, Binghampton, NY, USA, 3Everspectra, Boston, MA, USA, 4Penn State Milton S. Hershey Medical Center, Hershey, PA, USA, 5the University of Vermont, Burlington, VT, USA

497. Magnetic drug screening nanoplatform based on immobilized transmembrane kinase receptor proteins, Yuping Bao, Ph.D., The University of Alabama, Tuscaloosa, AL, USA

498. Ultra-absorptive Nanofiber Swabs for Improved Collection and Test Sensitivity of SARS-CoV-2, Alec McCarthy1, Lorenzo Saldana1, Daniel Ackerman2, Joshua Santarpia, PhD, Jingwei Xie, PhD1, 1University of Nebraska Medical Center, Omaha, NE, USA, 2National Strategic Research Institute, Omaha, NE, USA

499. Mitigating Cardiac Fibrosis Phenotype In Vitro with Drug Loaded Nanogels Treating Acute and Chronic Complications of Myocardial Infarction, Aryssa Simpson1,2, Emily Mihalko1,2, Ashley C. Brown, PhD1,2, 1University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, NC, USA, 2North Carolina State University, Raleigh, NC, USA

500. Comparative efficacy of resorbable fiber wraps loaded with gentamicin sulfate or. gallium maltolate in the treatment of osteomyelitis, Taneidra W. Buie 1, Michael Whitely 2, Anupriya Jose 1, Annika Balakrishnan 1, Joshua McCune 1, Ziyang Lan 1, Joseph Wenke 2, and Elizabeth Cosgriff-Hernandez 1,. University of Texas at Austin, US Army Institute of Surgical Research

501. CaproGlu Bioadhesives for Bacterial Infection Detection, Elizabeth Ellis, Ivan Djordjevic, Terry Steele, Nanyang Technological University, Singapore, Singapore

Engineering Cells and Their Microenvironments SIG

502. Single Cell Analysis of the Effect of Cardiovascular Device Topography on Endothelial Immunogenicity, Meghan Fallon, Monica Hinds, PhD, Oregon Health & Science University, Portland, OR, USA

503. A Phase Inversion-based Technique for Fabricating Bicontinuous Porous Scaffolds Junzhi Li, Haoran Sun, Min Wang * Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong. . . . . . .

504. Optimizing Extracellular Matrix Cues for Multipotent Stromal Cells Expansion and Differentiation, Alex Ho Pang Chan, PhD1,2, Kyung Sung, PhD3, Ngan Huang, PhD, FAHA1,2, 1Stanford University, Palo Alto, CA, USA, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA, 3Food and Drug Administration, Silver Spring, MD, USA

505. Profiling the Responsiveness of Focal Adhesions of Human Cardiomyocytes to Extracellular Dynamic Nano-Topography, Huaiyu Shi1,2, Shiyang Sun1,2, Chenyan Wang1,2, James Henderson, PhD1,2, Zhen Ma, PhD1,2, 1Department of Biomedical & Chemical Engineering, Syracuse, NY, USA, 2BioInspired Syracuse Institute for Materials and Living Systems, Syracuse, NY, USA

506. Microcontact Printing on Shape Memory Polymers for Altering Cell Morphology, Fred Donelson, MSE1, Jakub Kochanowski1, Christopher Turner, PhD2, James Henderson, PhD1, 1Syracuse University, Syracuse, NY, USA, 2SUNY Upstate Medical University, Syracuse, NY, USA

507. Thermo-responsive poly(oligoethylene glycol methacrylate) (POEGMA)-based nanofibrous hydrogels for fast cell delamination and cell adhesion, Fei Xu, PhD, Angus Lam, Zhicheng Pan, Gurpreet Randhawa, Makenzie Lamb, Heather Sheardown, Todd Hoare, McMaster University, Hamilton, ON, Canada

508. In Situ Crosslinking Chitosan-Genipin Hydrogel as an Injectable Cell Matrix, Tyler Priddy-Arrington1, Hao Zhang, PhD2, Yufeng Dong, Phd, MD2, Mary Caldorera-Moore, PhD1, 1Louisiana Tech University, Ruston, LA, USA, 2Louisiana State University Health Sciences Center, Shreveport, LA, USA

509. Engineering Injectable Synthetic ECM-Based Hydrogels as Vehicles for Retinal Progenitor Cells Transplantation, Peng Zhao1, Joydip Kundu1, Ashav Desai1, Sidi Bencherif1, Michael Young2, Rebecca Carrier1, 1Northeastern University, Boston, MA, USA, 2Schepens Eye Research Institute, Boston, MA, USA

510. Assessing Bundling of Wicking Fibers for Cellular Diagnostic Systems, Anahit Mehranian, Timothy Burg, Karen Burg, University of Georgia, Athens, GA, USA

511. Controlling cell-material interactions to tune therapeutic extracellular vesicle production, Stephen Lenzini, Sing Wan Wong, Angela Song, Raymond Bargi, Dolly Mehta, Jae-Won Shin, University of Illinois at Chicago, Chicago, IL, USA

512. Endotoxin and Cellular Activity, Jos Olijve, Rousselot-Biomedical, Gent, Belgium

513. Natural Selection Imposed by Mechanical Properties of a Biomaterial Results in Novel Cellular Phenotypes, Purboja Purkayastha1, Kavya Pendyala2, Ayush Saxena3, Hesamedin Hakimjavadi4, Srikar Chamala4, Purushottam Dixit4,5, Charles Baer3,4, Tanmay Lele1,2, 1Department of Chemical Engineering, Texas A&M University, College Station, TX, USA, 2Department of Biomedical Engineering,Texas A&M University, College Station, TX, USA, 3Department of Biology, University of Florida, Gainesville, FL, USA, 4University of Florida Genetics Institue, Gainesville, FL, USA, 5Department of Physics, University of Florida, Gainesville, FL, USA

Biomaterials for Regenerative Engineering

514. Electrospinning Live Cells Using Gelatin and Pullulan, Nasim Nosoudi, PhD, Marshall university, Huntington, WV, USA

515. Hydrogels with tunable glycan content to probe extracellular matrix-lectin interactions, Juanpablo Olguin, Matthew Molinaro, Liu Renjie, PhD, Eric Hill, Antonietta Restuccia, PhD, Gregory Hudalla, PhD, University of Florida, Gainesville, FL, USA

516. Development of Phosphatidylserine Presenting Particles for Targeting Macrophages in Tissue Regeneration, Kidochukwu Atube, Michael Gower, Ph.D., University of South Carolina, Columbia, SC, USA

517. ATRA-loaded PLG microparticles to direct macrophage regenerative function, Candice Cheung, MEng, Griffin Carter, Michael Gower, PhD, University of South Carolina, Columbia, SC, USA

518. Strontium – based nanocomposite hydrogels for Improved Anti-infective and Osteogenic Differentiation Activity, Isha Mutreja, PhD, Dhiraj Kumar, PhD, Tristen Nies, Kim Mansky, PhD, Conrado Aparicio, PhD, University of Minnesota, Minneapolis, MN, USA

519. Formation of a Primary Murine Perivascular Model to Study Hematopoietic Stem Cells In Vitro, Victoria Barnhouse, Brendan Harley, University of Illinois at Urbana-Champaign, Urbana, IL, USA

520. Electrospun Hydrogel Nanofiber Scaffolds for The Differentiation of Mesenchymal Stem Cells into Vascular Cells, Alex Rickel1, Junli Hu2, Zhongkui Hong1, 1University of South Dakota, Sioux Falls, SD, USA, 2Northeast Normal University, Changchun, China

521. Biocompatibility of Collagen Fiber-Derived Scaffolds for Tissue Engineering Applications. "Kiran Ali, BS, MS, Alaowei Amanah, BS, MS, Jessica Gluck, BS, MS, PhD, North Carolina State University, Raleigh, NC, USA

522. In-vivo evaluation of macrophage polarization in response to raspberry ketone-loaded electrospun chitosan membrane, Melika Esmaeili Rad1, Fernanda Guerra, PhD1, Kenneth Anderson, DDS. MS2, Omar Skalli, PhD3, Joel Bumgardner, PhD1, 1University of Memphis-University of Tennessee Health Science Center, Memphis, TN, USA, 2University of Tennessee Health Science center, Memphis, TN, USA, 3University of Memphis, Memphis, TN, USA

523. Collagen I and Modified Hyaluronic Acid Hydrogels for Tissue Engineering, Jessica Torres1, Fanfei Meng2, Kevin Buno3, Yoon Yeo2, Luis Solorio3, Julie Liu1, 1Purdue University Davidson School of Chemical Engineering, West Lafayette, IN, USA, 2Purdue University College of Pharmacy, West Lafayette, IN, USA, 3Purdue University Weldon School of Biomedical Engineering, West Lafayette, IN, USA

524. Mechanical Approximation of Ex Vivo Myocardium for Collagen Matrix Printing, Adam Baker, MS, Bruce Gao, PhD, Clemson University, Clemson, SC, USA

525. Tuning Granular Hydrogel Porosity to Modulate 3D Endothelial Cell Sprouting, Taimoor Qazi, PhD, Jason Burdick, PhD, University of Pennsylvania, Philadelphia, PA, USA

526. Characterization of a Tubular Synthetic Elastomeric Scaffold for the Potential Use in Urethral Substitution, Larry Wang1, Matthew Bury1, Yvonne Chan1, Xinlong Wang2, Guillermo Ameer, PhD2,3, Arun Sharma, PhD1,2,3,4,5, 1Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA, 2Northwestern University, Evanston, IL, USA, 3Simpson Querrey Institute, Chicago, IL, USA, 4Northwestern University Feinberg School of Medicine, Chicago, IL, USA, 5Stanley Manne Children’s Research Institute, Chicago, IL, USA

Biomaterials for Organoids

527. Microfluidic-assisted fabrication of macroporous hydrogel allows tunable spheroids assembly, Zhongliang Jiang, PhD, Fang-Yi Lin, PhD, Kun Jiang, MS, Chien-Chi Lin, PhD, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

528. Norbornene-modified poly(γ-glutamic acid) for orthogonal hydrogel crosslinking and 3D cell culture, Min Hee Kim, PhD, Chien-Chi Lin, PhD, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA

529. Enabling Tunable Mucoadhesion through Thiolation of Thermoresponsive Hydrogel Scaffolds, Ninad Kanetkar, Adam Ekenseair, PhD, Northeastern University, Boston, MA, USA

530. Chemically-defined hydrogels for generation of pancreatic organoids, Matthew Arkenberg, MS1, Chien-Chi Lin, PhD1,2, 1Purdue University, West Lafayette, IN, USA, 2Indiana University Purdue University-Indianapolis, Indianapolis, IN, USA

531. Frozen Films: Porous Thin Films For In Vitro Culture, Kailei Xu, Thomas Dieffenthaller, Zi Wang, Alicja Copik, Stephanie Florczyk, University of Central Florida, Orlando, FL, USA

532. Controlling Extracellular Matrix Environment in Guiding 3D Retinal Organoid Formation, Ronak Ansaripour1, Joydip Kundu1, Petr Baranov2, Julia Oswald2, Rebecca Carrier1, 1Northeastern University, Boston, MA, USA, 2Harvard Medical School, Boston, MA, USA

533. High-Throughput Analysis Reveals Microenvironmental Regulation of Primary Human Liver Sinusoidal Endothelial Cell Phenotype, Aidan Brougham-Cook1, Chase Monckton2, Daniel Owen1, Salman Khetani2, Gregory Underhill1, University of Illinois Urbana-Champaign, Urbana, IL, USA, 2University of Illinois Chicago, Chicago, IL, USA

534. 3D-printed living composites with programmable shape transformations, Laura Rivera-Tarazona1, Tarjani Shukla, PhD2, Zachary Campbell, PhD2, Taylor Ware, PhD1, 1Texas A&M University, College Station, TX, USA, 2The University of Texas at Dallas, Richardson, TX, USA

535. HYDROGEL-BASED MICROFLUIDIC DEVICE AS A 3D IN VITRO DRUG SCREENING PLATFORM, Joseph Bruns1, Allison Clancy1, Dayi Chen, PhD2, Jahnavi Nadella1, Aaron Timpermann, PhD2, Silviya Zustiak, PhD1, 1Saint Louis University, St. Louis, MO, USA, 2University of Illinois at Urbana-Champaign, Urbana, IL, USA

536. Degradable, Nanofiber-Reinforced Hydrogel Membranes for Guided Eardrum Repair, Kelsey Broderick1, Mallory Gasbarre1, Kelsi Smith1, Brie Janet1, Lauren Costella1, Bradley Kesser, MD2, Christopher Tison, PhD1, Lindsay Woodard, PhD1, 1Luna Innovations, Inc, Charlottesville, VA, USA, 2University of Virginia, Charlottesville, VA, USA

537. Improving Brain Organoid Models with a Biofunctionalized Hydrogel, Kylie Balotin, BS, Lauren Drake, BSE, Neelansh Bute, Brian O'Grady, PhD, Ethan Lippmann, PhD, Vanderbilt University, Nashville, TN, USA

538. Photopatterning of spatially organized 3D cultures in microfluidic devices, Tochukwu Ozulumba, PhD, Jennifer Ortiz-Cárdenas, Jonathan Zatorski, Amirus Salaheen, PhD, Rebecca Pompano, PhD, University of Virginia, Charlottesville, VA, USA

539. Incorporation of Extracellular Matrix-Derived Biomaterials into an Intervertebral Disc Organoid Model, Karenna Smith, Jeremy Mercuri, PhD, Clemson University, Clemson, SC, USA

540. Engineering single cell polarity in three-dimensional matrices, Ik Sung Cho, Ph.D., Sing Wan Wong, Ph.D., Stephen Lenzini, M.S., Jae-Won Shin, Ph.D., University of Illinois at Chicago, Chicago, IL, USA

541. Effect of Mechanical Strain on Myokine Secretion and its Role in Diabetic Bone Disease, Edwina Barnett, B.S. Biology, Evangelia Kalaitzoglou, MD, John Fowlkes, MD, Ramkumar T. Annamalai, PhD, University of Kentucky, Lexington, KY, USA

542. Development of a Physiomimetic Microsystem for the Study of Metabolic Activity Zonation of the Liver, Madeline Helm, Dennis McDuffie, Ashutosh Agarwal, PhD, Biomaterials for Neural and Ophthalmic Applications, University of Miami, Miami, FL, USA

Biomaterials for Neural and Ophthalmic Applications

543. Novel Biomaterials for Corneal Repair, Nasim Annabi, PhD1, Islam Khalil, PhD2,3, Bahram Saleh, PhD2, Dina Mohsen2, 1University of California, Los Angeles, Los Angeles, CA, USA, 2Northeastern University, Boston, MA, USA, 3Misr University of Science and Technology, Giza, Egypt

544. Prediction of Long Term Biostability of Polymeric Medical Device Using an In Vitro Model, James Wu, PhD, Rebecca Rice, DVM, PhD, Xingfeng Shi, PhD, Alcon, Fort Worth, TX, USA

545. Mucoadhesion and mucopenetration of self-assembled poly(lactic acid)-block-poly(oligoethylene glycol methacrylate) block copolymer nanoparticles with different ethylene oxide side-chain lengths, Ridhdhi Dave, Heather Sheardown, PhD, Todd Hoare, PhD, Andrew Singh, Maya Ziolowska, McMaster University, Hamilton, ON, Canada

546. Engineering Synthetic ECM using Peptide Modified Alginate Hydrogel to Study Human Nucleus Pulposus Cell Fate, Xiaohong Tan1, Era Jain, PhD1, Marcos Barcellona1, Sydney Neal1, Munish Gupta2, Jacob Buchowski2, Michael Kelly2, Lori Setton, PhD1, Nathaniel Huebsch, PhD1, 1Washington University in St. Louis, Saint Louis, MO, USA, 2Washington University School of Medicine, Saint Louis, MO, USA

547. Characterizing the effect of Cerebral Amyloid Angiopathy-induced vessel stiffening on the blood-brain barrier, Allison Bosworth1, Hyosung Kim, PhD2, Kristin O'Grady, PhD3, John Snider, PhD1, Isabella Richter1, Lynn Lee2, Matthew Schrag, MD, PhD4, David Merryman, PhD1, Ethan Lippmann, PhD1,2,4, 1Vanderbilt University Biomedical Engineering, Nashville, TN, USA, 2Vanderbilt University Chemical Engineering, Nashville, TN, USA, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, USA, 4Vanderbilt University Department of Neurology, Nashville, TN, USA

548. Thermogelling polymer molecular weight effect on suitability as a vitreous replacement, Kun Xue, PhD1, Zengping Liu2, Qianyu Lin2, Xinyi Su, MBBS/PhD2, Xian Jun Loh, PhD1,2, 1Institute of Materials Research and Engineering, A*STAR, Singapore, Singapore, 2National University of Singapore, Singapore, Singapore

549. Therapeutic Delivery by Polydopamine Nanoparticles for Treatment of Ocular Inflammation and Angiogenesis, Megan Allyn, Andrew Choi, Andre Palmer, PhD, Katelyn Swindle-Reilly, PhD, The Ohio State University, Columbus, OH, USA

550. Evaluation of Polymethyl methacrylate changes as glaucoma drainage device in the rabbit, Virna Asrory, PhD, Faculty of Medicine University of Indonesia/ Cipto Mangunkusumo Hospital, Jakarta, Indonesia

551. Human-Derived Collagen: An Allogenic Approach for Tissue Engineering in Neurosurgery and Otologic Applications, Grecia Cardoso-Hernández1, Brenda Aguillon-Estrada1, Fabian Rho-Mas2, Beni Camacho-Perez, PhD1, Juan Pablo Aguilar Alemán, PhD1,2, 1Top Health S.A.P.I. de C.V., Zapopan, Mexico, 2Tecnologico de Monterrey, Zapopan, Mexico

552. Can poly-ethylene glycol be a trigger for a “side-by-side” axonal fusion mechanism ?, Antonio Merolli, MD1, Cemile Bektas, PhD1, Yong Mao1, Robert Shultz2, 1Rutgers University, Piscataway, NJ, USA, 2University of Pennsylvania, Philadelphia, PA, USA

553. The Influence of Laminin 511 hydrogels on Neural Stem Cell Fate, Diana Philip, MSc.1, Ivana Shah1, Rebecca Willits, PhD1,2, 1The University of Akron, Akron, OH, USA, 2Northeastern University, Boston, MA, USA

554. Development of a Bovine Intervertebral Disc Herniation Organ Culture Model to Evaluate Regenerative Biomaterials, Christopher Theos, Mario Krussig, Joshua Walters, PhD, Jeremy Mercuri, PhD, Clemson University, Clemson, SC, USA

555. Progress in the study of axonal fusion: single-axon hand-cut with a standard surgical blade in a 3D-printed scaffold, Cemile Bektas, PhD, Joseph Molde, PhD, Yong Mao, PhD, Antonio Merolli, MD, Rutgers University, Piscataway, NJ, USA

Biomaterials for Pulmonary Applications

556. Integrating clickable, decellularized extracellular matrix into photoaddressable hybrid-hydrogels, Rukshika Hewawasam, PhD1, Predrag Serbedzija, PhD1, Kamiel Saleh1, Chelsea Magin, PhD1,2,3, 1University of Colorado Denver | Anschutz Medical Campus, Aurora, CO, USA, 2University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 3University of Colorad Anschutz Medical Campus, Aurora, CO, USA

557. Antimicrobial and Antioxidant Shape Memory Polymer Foams, Changling Du, Jingyi Liu, David Fikhman, Mary Monroe, Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA

558. In Vitro pO2 Measurement of Islet Encapsulation Devices in Oxygen Measurement Core, Mrignayani Kotecha, PhD1, Zhengshan Zhao, PhD1, Darwin Bodero1, Longhai Wang2, Alexander Ernst2, Minglin Ma2, Corinne Hoesli3, Cherie Stabler4, Klearchos Papas5, Boris Epel, PhD6, 1O2M Technologies, LLC, Chicago, IL, USA, 2Cornell University, Ithaca, NY, USA, 3McGill University, Montreal, QC, Canada, 4University of Florida, Gainesville, FL, USA, 5University of Arizona, Tucson, AZ, USA, 6The University of Chicago, Chicago, IL, USA

559. Trityl Radical OX071, an EPR Oxygen Imaging Spin Probe, Is Non-Toxic to Cells, Zhengshan Zhao1, Darwin Bodero1, Boris Epel2, Mrignayani Kotecha1, 1O2M Technologies, LLC, Chicago, IL, USA, 2The University of Chicago, Chicago, IL, USA

560. Methodology for Biomaterial Oxygen Imaging Using Trityl Based Pulse Electron Paramagnetic Resonance, Boris Epel1, Mrignayani Kotecha2, 1The University of Chicago, Chicago, IL, USA, 2O2M Technologies, LLC, Chicago, IL, USA

562. Oxygen Modeling-Aided Design of Hydrogel Macroencapsulation Device Geometry for Improved Long-Term Islet Survival, Amy Emerson, Alec McCall, Sarah Brady, Jessica Weaver, Arizona State University, Tempe, AZ, USA

563. Magnetically Aggregated 3D Hydrogel Microsphere Models of Pulmonary Fibrosis, Thomas Caracena, BS1, Rukshika Hewawasam, PhD1, Chelsea Magin, PhD1,2, 1University of Colorado, Denver | Anschutz, Aurora, CO, USA, 2University of Colorado, Anschutz Medical Campus, Aurora, CO, USA

564. Bioinspired Elastin-Based DOPA-Modified Protein Lung Sealants, Jessica Torres, Julie Liu, Purdue University Davidson School of Chemical Engineering, West Lafayette, IN, USA

565. Utilizing a closed bath imaging chamber for oxygen sensing in ex vivo tissue models, Parris Anbaei, Drake Dixon, Rebecca Pompano, PhD, University of Virginia, Charlottesville, VA, USA

566. Engineered gel coating enables mesenchymal stromal cells to resolve pulmonary fibrosis, Sing Wan Wong, Ph.D.1, Chandra Tamatam, Ph.D.1, Ik Sung Cho, Ph.D., Peter Toth, Ph.D.1, Raymond Bargi1, Patrick Belvitch, M.D.1, James Lee, Ph.D.1, Jalees Rehman, M.D.1, Sekhar Reddy, Ph.D.1, Jae-Won Shin, Ph.D.1, 1University of Illinois at Chicago, Chicago, IL, USA

567. Naturally Derived Powder-Based Lung Tissue Sealant for Pleural Defects Utilizing a Murine Model, Rachael Oldinski-Floreani, PhD1, Patrick Charron1, Spencer Fenn, PhD1, Minara Aliyeva2, Nirav Daphtary, PhD2, Lennart Lundblad, PhD2, 1University of Vermont, Burlington, VT, USA, 2UVM Larner College of Medicine, Burlington, VT, USA

568. HUVEC Tubular Formation on Bio-Inspired Substrate for Promoting Angiogenesis, Rachael Oldinski-Floreani, PhD, Irfan Tahir, Patrick Charron, Luis Garcia, The University of Vermont, Burlington, VT, USA

Nanomaterials SIG

106. Multi-step Compositional Screening of pDNA Lipid Nanoparticles to Optimize Transfection Efficiency for Oral Gene Delivery, Yizong Hu, Yining Zhu, Hai-Quan MaoJohns Hopkins University, Baltimore, MD, USA

569. Active Learning Driven Design of Enzyme Stabilizing Polymers, Matthew Tamasi, Shashank Kosuri, Sabarish Selvarajan, Adam Gormley, PhD, Rutgers University, Piscataway, NJ, USA

570. Preparation and characterization of biodegradable metal particle incorporated polycaprolactone nanofibers, Dekonti Davies, Sheikh Saudi, Jagannathan Sankar, Narayan Bhattarai, North Carolina Agricultural and Technical State University, Greensboro, NC, USA

571. Probing the topography and mechanical properties of biomaterials with atomic force microscopy, André Koernig, Torsten Mueller, Tanja Neumann, Bruker Nano GmbH, JPK BioAFM, Berlin, Germany

572. Understanding Nanotoxicity: Gold Nanoparticles Impact Calcium Influx, Jaspreet Singh Nagi Nagi, MS, Amber Doiron, PhD, University of Vermont, Burlington, VT, USA

573. Fluorescent Nanodiamond –Hyaluronate Conjugates for Molecular Imaging, Hyehyeon Han, MS, Seikwang Hahn, PhD, POSTECH, Pohang, Republic of Korea

574. Low temperature Plasma processing for fabricating metal nanoparticles coated antimicrobial surfaces for potential biomedical applications, Vineeth Vijayan, Yogesh Vohra, Vinoy Thomas, University of Alabama at Birmingham, Birmingham, AL, USA

575. Mechanical Tension in Syndecan-1 is Regulated by Extracellular Mechanical Cues, Lei Mei, Victoria Le, Peter Voyvodic, Chi Zhao, David Busch, Jeanne Stachowiak, Aaron Baker, The University of Texas at Austin, Austin, TX, USA

576. Preparation of Polyproline Materials via Transition-Metal Catalysis of N-Carboxyanhydrides, Rachel Detwiler, Austin Schlirf, MS, Jessica Kramer, PhD, University of Utah, Salt Lake City, UT, USA

577. Assessment of Regenerative Benefits of MSC-derived Smooth Muscle Cells to in vivo Elastic Tissue Repair,. Shataakshi Dahal and Anand Ramamurthi. Cleveland Clinic, Cleveland, OH, Lehigh University, Bethlehem, PA