Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Track: Tissue Engineering and Regenerative Medicine
Room: Virtual
About
Bio-metals are employed in various forms to substitute for damaged structural components and to restore lost functions within the human body for the purpose of tissue engineering/regenerative medicine. A favorable combination of tensile strength, fracture toughness and fatigue strength warrant their application in orthopedics, as artificial joints, plates and screws, in orthodontics and dentistry, as braces and dental implants, and as cardiovascular and neurosurgical devices, such as artificial heart, staples, stents, wires and coils. Compared to polymer and ceramic biomaterials, metals are characterized by higher electro-conductivity, and as such have been employed to enclose electrodes in artificial electronic organs. Lately, biodegradable metals emerged as a new generation of medical implants for regeneration. This symposium aims to highlight the latest developments of metals and their applications in tissue engineering/regenerative medicine.
Moderators:
Kelvin Yeung, PhD.
David Mills, PhD.
Bingyun Li, PhD.
Abstracts
Abstracts will be available for download on April 20, 2021.
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21. Therapeutic Delivery of Smooth Muscle Cells Encapsulated in Porous Collagen Scaffolds for Treatment of Abdominal Aortic Aneurysm, Ngan Huang1, Joscha Mulorz1,2, Cynthia Alcazar2, Caroline Hu2, Mahdis Shayan1, Yan Wen, Mason Briggs1, Joshua Spin1,2, Bertha Chen1, Philip Tsao1,21Stanford University, Palo Alto, CA, USA, 2Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
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22. Machine learning guided biomaterials development, Ying Mei, PhD1, Sophia Silver1, Jianjun Hu, PhD21Clemson University, Charleston, SC, USA, 2University of South Carolina, Columbia, SC, USA
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23. Antibacterial and biocompatible Co-Cr surface via Sputtering-based Metal Ion Etching, Hyoun-Ee Kim, PhD1, Tae-Sik Jang, PhD2, Chang-Ha Hwang, BS1, Minkyu Lee, BS11Seoul National University, Seoul, Republic of Korea, 2Chosun University, GWANGJU, Republic of Korea
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24. Dielectric Barrier Discharge Plasma Enhances Cellular Response of MSCs and Osteoblasts In Vitro and Improves Osseointegration In Vivo in a Rabbit Femur Model, Michael Berger1, D. Joshua Cohen, MB1, Kyla Bosh1, Michael Levit1, Barbara Boyan, PhD1,2, Zvi Schwartz, PhD, DMD1,31Virginia Commonwealth University, Richmond, VA, USA, 2Georgia Institute of Technology, Atlanta, GA, USA, 3University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
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25. Improved Mechanical Property and Biocompatibility of Binary Zinc Alloys, Yingchao Su, PhD1, Yufeng Zheng2, Yadong Wang3, Donghui Zhu11Stony Brook University, Stony Brook, NY, USA, 2Peking University, Beijing, China, 3Cornell University, Ithaca, NY, USA
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26. Use of Transient Cuff Electrodes for Chronic HFAC Conduction Nerve Block Implants, Emily Ray, Sabrina GenoveseWashington University School of Medicine in St. Louis, St. Louis, MO, USA
BioInterfaces SIG
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Track: Functional Biomaterials and Surfaces
Room: Virtual
About
The BioInterfaces Special Interest Group seeks to promote a better understanding of cell and protein interactions with biomaterial interfaces. To achieve these goals, the group organizes activities related to the evaluation of existing materials and the design of new materials to produce targeted responses by proteins and cells. Some of the topics related to proteins include: 1) relating surface chemistry to protein adsorption or specific binding and 2) studying the activation or inactivation of protein function at interfaces, including complement activation. Cell topics include: 1) the response of cells to differing chemistries and microstructures (roughness or porosity), 2) the evaluation of multiple cell and tissue response parameters (attachment, growth, migration, differentiation, inflammation, fibrosis), 3) the role of surface receptors in cell responses, and 4) all relevant cell types including bacteria. The group organizes workshops, symposia, and sessions at the annual meeting.
Moderator:
Stephanie Florczyk, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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9. Improved Biocompatibility of Polymer Biomaterials by Surface Texturing and Nitric Oxide Release, Christopher Siedlecki, PhD, Lichong Xu Xu, PhDPenn State University College of Medicine, Hershey, PA, USA
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10. Advanced Glycation-End Product Cross-links on Collagen Regulates Myoblast Proliferation and Differentiation, Lucas Olson, BS1, Zvi Schwartz, DMD, PhD1,2, Barbara Boyan, PhD1,3, Michael McClure, PhD11Virginia Commonwealth University, Richmond, VA, USA, 2University of Texas Health Science Center at San Antonio, San Antonio, TX, USA, 3Georgia Institute of Technology, Atlanta, GA, USA
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11. Dynamic Microgels for Expansion of Mesenchymal Stem Cells, Han Nguyen, MS1, Zhongliang Jiang, PhD2, Chun-Yi Chang, MS1, Chien-Chi Lin, PhD1,21Purdue University, West Lafayette, IN, USA, 2Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA
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12. Variation of Chitosan-Hyaluronic Acid Scaffold Processing Parameters Produces In Vitro Breast Cancer Tumor Microenvironments That Promote Different Phenotypes, Zi Wang, PhD, Kailei Xu, PhD, Dana Rowley, BS, Minh-chau Le, PhD, Annette Khaled, PhD, Stephanie Florczyk, PhDUniversity of Central Florida, Orlando, FL, USA
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13. Design Build and Validate Strategy to 3D Print Biomimetic Bioglass Gradient Matrices for ACL Reconstruction, Nilabh Kajave, Trevor Schmitt, Vipuil KishoreFlorida Institute of Technology, Melbourne, FL, USA
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14. Gene Expression Analysis in Tissue-Microelectrode Interface of Cd14-/- and WT Mice Reveals Potential Secondary Molecular Target in Neuroinflammatory Pathway, Sydney Song1, Hillary Bedell1, Evon Ereifej2, Ricky Chan1, Jeffrey Capadona11Case Western Reserve University, Cleveland, OH, USA, 2Veterans Affairs Ann Arbor Health Care System, Ann Arbor, MI, USA
Biomaterials Education SIG
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Track: Career Catalysis
Room: Virtual
About
The Biomaterials Education SIG members' mission is to affect quality of teaching and learning through the discussion, generation and implementation of innovative ideas. Through this, they seek to advance the interests and goals of the biomaterials community by attempting to bridge the gap between classroom theory and clinical application. As the field of biomaterials rapidly evolves, so must biomaterials education. The Biomaterials Education Special Interest Group is dedicated to the belief that all members of the biomaterials community should be provided with high quality educational opportunities in a stimulating environment.
Moderator:
Amber Jennings, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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15. Teaching Standardization of Bioprinting, Liisa Kuhn, PhD1, Sangya Varma, PhD21University of Connecticut, Storrs, CT, USA, 2Rutgers, The State University of New Jersey, New Brunswick, NJ, USA
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16. Teaching students in the field of Dental materials science in the COVID-19 pandemic setting in Varna, Bulgaria, Mario Milkov, PhD1, Miroslav Stoykov1, Ivaylo Parushev, PhD1, Stefan Peev, PhD, DSc2, Daniela Petrova11Faculty of Dental medicine, Medical University "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria, 2Medical University "Prof. Dr. Paraskev Stoyanov", Varna, Bulgaria
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17. Customer Discovery Processes to Realize Commercially Ready Biomaterials Technologies, Karen Burg, Timothy BurgUniversity of Georgia, Athens, GA, USA
Black and LatinX Voices in Biomaterials Science and Engineering
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Room: Virtual
About
The purpose of this session is to highlight the research conducted by Black and Latinx in biomaterials, and to provide a safe and inclusive space for attendees to learn about the experiences of minoritized early-career biomaterials scientists and engineers and freely ask questions. The Session will begin with a brief introduction to the mission and role communities followed by research presentations by the invited speakers. After the presentations, there will be a panel-style open Q&A and discussion, where attendees will be able to ask questions relevant to both the research and the personal struggles of the speakers.
Abstracts
Abstracts will be available for download on April 20, 2021.
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Moderators:
Brian Aguado, PhD
Edward Botchwey, PhD
Ana Maria Porras, PhD -
28. Controlling Multi-Peptide Organization in 3D-Printed Scaffolds to Drive Osteochondral Tissue Formation, Paula Camacho, Matthew Fainor, Anne Behre, Hannah Dailey, Lesley ChowLehigh University, Bethlehem, PA, USA
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29. Nail Matrix Regenerative Engineering: In Vitro Evaluation of Poly(lactide-co-glycolide)/Gelatin Fibrous Substrates, Aundrya Montgomery, MS, Aneesah McClinton, MD, Lakshmi Nair, PhD, Cato Laurencin, MD, PhD, UConn Health, Farmington, CT, USA
Invited Speaker(s)
Immunomodulatory Biomaterials 1
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Track: Immunomodulatory Biomaterials
Room: Virtual
About
The session will focus on engineered biomaterials for therapeutic immune modulation. Specifically, the session will cover topics ranging from biomaterials for delivery of immunomodulators and imaging agents, scaffolds for immunomodulation, cellâ€based therapies, etc. Several cutting edge immune engineering platforms will be included.
Moderator:
Ashish Kulkarni, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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35. Engineering Injectable Artificial T-Cell Stimulation Microparticles, Natalie Livingston, B.S., John Hickey, PhD, Sebastian Salathe, B.S., Hai-Quan Mao, PhD, Jonathan Schneck, MD, PhDJohns Hopkins University, Baltimore, MD, USA
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36. Stimuli-Responsive Nanoreporter for Early Monitoring of Immunotherapy Response, Anujan Ramesh Ramesh1, Sahana Kumar2, Dipika Nandi3, Anthony Brouillard2, Alexandria Wells3, Leonid Pobezinsky, Ph.D.3,4, Barbara Osborne, Ph.D.3,4, Ashish Kulkarni, Ph.D.1,2,3,4, Anh Nguyen21University of Massachusetts in Amherst, Amherst, MA, USA, 2University of Massachusetts Amherst, Amherst, MA, USA, 3University of Massachusetts, Amherst, Amherst, MA, USA, 4University of Massachusetts - Amherst, Amherst, MA, USA
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37. Harnessing Sustained Release to Produce Robust, Durable, and High-Quality Influenza Immunity, Gillie Roth, PhD1, Olivia Saouaf2, Eric Appel, PhD1,21Stanford University School of Medicine, Stanford, CA, USA, 2Stanford University, Stanford, CA, USA
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38. Plasticity of primary human macrophages in crosstalk with scaffolds and tissue-engineered blood vessels, Beatriz Hernaez-Estrada, Grad Student1,2, Edorta Santos-Vizcaino, PhD1,3,4, Rosa Hernandez, PhD1,3,4, Kara Spiller, PhD21University of the Basque Country, Vitoria-Gasteiz, Spain, 2Drexel University, Philadelphia, PA, USA, 3Bioaraba, Vitoria-Gasteiz, Spain, 4Instituto de Salud Carlos III, Madrid, Spain
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39. Take-Out or Dine-in: Immunogenicity of Peptide Nanofibers Presenting Exogenous or Endogenous Forms of the Same Antigen, Paresh Shrimali, PhD, Jeremy Buck, BS, Darren Kim, BA, Jai Rudra, PhDWashington University in Saint Louis, Saint Louis, MO, USA
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40. The Extracellular Matrix Scaffold Type-2 Host Immune Response Facilitates Cancer Protection, Matthew Wolf, PhD1,2,3, Sudipto Ganguly, PhD3, Radhika Narain, MS2, Drew Pardoll, MD, PhD3, Jennifer Elisseeff, PhD2,31National Cancer Institute, Frederick, MD, USA, 2Johns Hopkins University, Baltimore, MD, USA, 3Johns Hopkins University School of Medicine, Baltimore, MD, USA
STAR Awards - Session 1
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
About
BioInterfaces
266. "Using Vesicle Lipid Domains to Enhance Liposomal TRAIL," Timothy Vu
12. "Variation of Chitosan-Hyaluronic Acid Scaffold Processing Parameters Produces In Vitro Breast Cancer Tumor Microenvironments That Promote Different Phenotypes," Zi Wang
Biomaterials Education
"Development and Optimization of a 3D printed strategy for Contiguous Culture of Dorsal Root Ganglion Cells and Endothelial Cells," Binata Joddar
Biomaterials & Medical Products Commercialization
24. "Dielectric Barrier Discharge Plasma Enhances Cellular Response of MSCs and Osteoblasts In Vitro and Improves Osseointegration In Vivo in a Rabbit Femur Model," Michael Berger
49. "Conducting Polymer Nanofibers for Biorobotics," Mohammadjavad Eslamian
Biomaterial-Tissue Interaction
66. "Laminin Interactions with the Islet In a 3D Reverse Thermal Gel Scaffold Protect Against Cytokine-Mediated β-cell death," Meghana Hosahalli Shivananda Murthy
14. "Gene Expression Analysis in Tissue-Microelectrode Interface of Cd14-/- and WT Mice Reveals Potential Secondary Molecular Target in Neuroinflammatory," Sydney Song
Cardiovascular Biomaterials
378. "Immobilization of a Collagen-mimicking Peptide to the Surface of Poly(vinyl alcohol) Hydrogels Promotes Endothelialization While Minimizing Thrombosis," Novella Bates
168. "Mechanical Performance of a Hydrogel-Fiber Mesh Composite as a Synthetic Heart Valve Material," Shruti Motiwale
Drug Delivery
110. "Engineering Lipid Nanoparticles for In Utero mRNA Delivery," Margaret Billingsley
140. "Scalable Parallelized Microfluidic Device for Precise RNA Lipid Nanoparticle Formulations," Sarah Shepherd
Engineering Cells & Their Micronenvironments
191. "In vitro Generation of Antibody Class-Switched Primary B Cells Using Liposome-Based Presentation of Antigen," Liana Kramer
152. "Dissecting the Microenvironmental Control of Liver Stellate Cell Epigenetics and Fibrogenic Phenotypes," Ishita Jain
Abstracts
Abstracts will be available for download on April 20, 2021.
Translational organ-on-a-chip technology
Timeslot: Wednesday, April 21, 2021 - 10:45am to 12:15pm
Room: Virtual
About
The adoption of microfluidics, lab-on-a-chip, organ-on-a-chip, and other advanced in vitro three-dimensional (3D) modeling techniques are increasingly used in studying normal functions, disease state and developing drugs and theranostics. In addition to advantages they may offer over conventional in vitro cell culture and animal experimentation, these technologies have their own specific properties and limitations. Many approaches use the same biomaterials and microfabrication techniques, and some have advanced to commercialization, but there are still biomaterial and process-based risks which must be reasonably determined, addressed and reduced to an acceptable level. These emerging technologies are noted in priority by FDA, evidenced by participation in the NIH Tissue Chip Consortium and through FDA publications and meetings over the past several years. There are notable examples of products in different countries, and there has been early adoption in various research-level projects. The ultimate promise is the potential to use these technologies as an accepted drug testing modality, which when validated and standardized may largely reduce the use of experimental animals and reduce problems associated with two-dimensional (2D) cell culture models. Adoption will be reflected by industrial advancement of biomedical products well beyond the current limits. This special panel comprises presentations and a discussion focused on various translational considerations of 3D on-a-chip devices, including (1) advancing technology out of the lab, and (2) commercialization of technologies into products for broad clinical use. This will include also discussion of standards, safety, regulatory and funding aspects.
Moderator:
Nureddin Ashammakhi, MD, PhD
Scott Taylor
Abstracts
Abstracts will be available for download on April 20, 2021.
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41. Effects of macrophage phenotype on osteogenic differentiation of MSCs in the presence of wear particles, Qi Gao, PhD1, Claire Rhee1, Masahiro Maruyama1, Zhong Li2, Huaishuang Shen1, Zhenyu Yao1, Bruce Bunnell3, Hang Lin2, Rocky Tuan2, Stuart Goodman11Stanford University, Palo Alto, CA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA, 3University of North Texas, Fort Worth, TX, USA
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42. Serial Assessment of Pancreatic Islets in 3D Organoid Microphysiological System Demonstrates Retention of Function
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43. Engineered human tissues for assessing cosmic radiation damage, Daniel Tavakol1, Trevor Nash1, Manuel Tamargo1, Youngbin Kim1, Sharon Fleischer, PhD1, Martin Liberman1, Guy Garty, PhD2, Joriene de Nooij, PhD3, David Brenner, PhD2, Gordana Vunjak-Novakovic, PhD11Columbia University Biomedical Engineering, New York City, NY, USA, 2Columbia University Center for Radiological Research, New York City, NY, USA, 3Columbia University Medical Center, New York City, NY, USA
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44. CARTiFlo: A Glioblastoma-on-Chip Platform to Assess In Vitro Potency of CAR T Cell Therapy, Chaitanya Tondepu, Meghan Logun, Yang Liu, Leidong Mao, PhD, Lohitash KarumbaiahUniversity of Georgia, Athens, GA, USA
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45. The NIH Tissue Chips Program: Novel tools for translational science, Lucie Low NCATS/NIH