Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Sensory Biomaterials and Tissues
Room: Virtual
About
Bioelectronics, electronics designed to interface with biology in vitro and in vivo, are an important class of biomaterials that are gaining significant interest. Bioelectronic devices include: (i) wearable sensors for health monitoring, (ii) in vitro diagnostics and biosensors that provide an electrical signal output proportional to an analyte, (iii) implantable devices (e.g. pacemakers, blood glucose monitoring, drug delivery, optoelectronics), (iv) electrophysiology (ECG, EMG, EEG) and (v) electrical stimulation of cells or tissues for tissue engineering, enhanced regeneration and therapeutic intervention. This symposium will highlight recent efforts in bioelectronic devices and electronically & ionically conducting biomaterials as well as their in vitro and in vivo application. Presentations will also cover material and fabrication advances for improved properties such as size, softness, flexibility, degradability, biocompatibility, and biointegration.
Moderator: Alexandra Rutz
Abstracts
Abstracts will be available for download on April 20, 2021.
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48. Conductive Micro-Containers for Controlled Release of Anti-Brain Tumor Therapeutic, Omid Dadras Toussi, Mohammadjavad Eslamian, Milad Khorrami, PhD, Mohammad Reza AbidianUniversity of Houston, Houston, TX, USA
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49. Conducting Polymer Nanofibers for Biorobotics, Mohammadjavad Eslamian, Fereshtehsadat Mirab, Vijaykrishna Raghunathan, PhD, Sheereen Majd, PhD, Mohammad Reza Abidian, PhDUniversity of Houston, Houston, TX, USA
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50. Identifying Fabrication Parameters for Tuning Material Properties of Electrochemically Aligned Collagen Threads with Deep Neural Networks, Wenhuan Sun1, Victoria Webster-Wood, PhD1,21Dept. Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA, 2Dept. Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA
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51. Wireless Smart Contact Lens for Diabetic Diagnosis and Therapy, Su-Kyoung Kim, Ph.D Candidate, Sei Kwang Hahn, ProfessorPohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
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52 Biomaterial Innovations through Understanding Brain-Technology Interfaces Takashi Daniel Yoshida Kozai, University of Pittsburgh
Invited Speaker(s)
Biomaterials for Regenerative Engineering - 1
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Tissue Engineering and Regenerative Medicine
Room: Virtual
About
Due to disease, degeneration, or trauma, there is a tremendous need to repair damaged tissues and organs. Although surgical replacement can be performed to address this issue, the insufficient number of donors greatly limits the applicability of this approach. Therefore, it is essential to develop engineered multifunctional biomaterials to promote tissue regeneration. Regenerative engineering combines biomaterial-based approaches with stem cell therapies and developmental biology to regenerate or repair tissues and organs. This symposium will cover tunable biocompatible materials such as hydrogels, fibers, proteins, carbohydrates, nano/micro-porous scaffolds, and metals, to modulate cellular microenvironments. The biomaterials that can direct cell fate and promote differentiation will also be highlighted by this session. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. Furthermore, we will include discussions for the development and commercialization of various medical devices such as blood contacting implants, prostheses, and pacemakers in the session. In addition to engineering approaches, we will provide discussions on clinical translation of biomaterial-based strategies. We will also include topics that are relevant to the rapidly changing circumstances associated with the Novel Coronavirus to improve patient putcomes. We expect that our interdisciplinary session including material science, chemistry, biology, engineering, and medicine will be of great significance to the clinicians, industry members and professors in academia.
Moderators:
Gulden Camci-Unal
Cato Laurencin
Abstracts
Abstracts will be available for download on April 20, 2021.
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54. Water-in-Oil Emulsion Bioink for 3D Bioprinting of Living Rigid Scaffolds, Yonghui Ding, PhD, Cheng Sun, PhD, Guillermo Ameer, DScNorthwestern University, Evanston, IL, USA
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55. Nucleic Acid-Collagen Complexes (NACCs) Stabilization via Physiological Ions, Paxton James, Bryan James, Josephine AllenUniversity of Florida, Gainesville, FL, USA
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56. Nucleic Acid Elastin Collagen Complex (NAECC) Fibers and Gels Working Towards an ECM Mimic, Sophia Saenz, Bryan James, Josephine AllenUniversity of Florida, Gainesville, FL, USA
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57. Novel 3D printed poly (ethylene glycol) dimethacrylate based photocurable scaffolds for cranial bone regeneration in the Lewis rat model, Janitha Unagolla, MS1, Champa Jayasuriya, Ph.D21University of Toledo, Toledo, OH, USA, 2University of Toledo Health science campus, Toledo, OH, USA
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58. Bio-Mimetic Peptide Nanofiber Hydrogel Promotes Regenerative Healing in the Murine and Porcine In Vivo Models, Maksym Krutko, Daria Narmoneva, PhD, Nava Rijal, Aditya Kaul, Swathi Balaji, PhD, Shelby CarrUniversity of Cincinnati, Cincinnati, OH, USA
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59. ROS degradable Urethane Scaffold Mediated Repair of Porcine Excisional Wounds, Prarthana Patil1, Katherine Russo1, Joshua McCune1, Alonda Pollins2, Nancy Cardwell2, Jeffery Davidson2, Scott Guelcher1, Craig Duvall11Vanderbilt University, Nashville, TN, USA, 2Vanderbilt University Medical Center, Nashville, TN, USA
Invited Speaker(s)
Cardiovascular Biomaterials SIG 1
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Cardiovascular Biomaterials
Room: Virtual
About
The Cardiovascular Special Interest Group has the mission to foster the professional interaction and address the common concerns of academic and industrial scientists and engineers, clinicians, and regulatory professionals concerned with the discovery, research, development, and use of biomaterials for cardiovascular devices and implants.
Moderator:
Ngan F. Huang, PhD
Chris Bashur, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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61. Antagonistic Effect of Magnesium Hydroxide Nanoparticle on Vascular Endothelial Activation Induced by Acidic PLGA Degradation Product, Kyoung-Won Ko, Dong Keun HanCHA University, Seongnam-si, Republic of Korea
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62. Deceasing tissue stiffness improves extracellular matrix hydrogel therapeutic efficacy for myocardial infarction, Xinming Wang, MS, Samuel Senyo, PhD, Paul Park, PhDCase Western Reserve University, Cleveland, OH, USA
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63. Model-directed Design of Kink Resistant Vascular Grafts with High Compliance, Andrew Robinson1, David Jiang2, Lucas Timmins, PhD2, Elizabeth Cosgriff-Hernandez, PhD11The University of Texas at Austin, Austin, TX, USA, 2The University of Utah, Salt Lake City, UT, USA
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64. Revelation of Vasculature Tree Structure Inside Sesamoid Bone and Its Impact on Bone Mechanical Integrity, Guigen Zhang, PhD1, Erik Davis, BS1University of Kentucky, Lexington, KY, USA
Engineering Cells and Their Microenvironments SIG - 1
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Engineered Microenvironments
Room: Virtual
About
This session will focus on research that describes biomaterials-based approaches for influencing cellular behaviors and fates, which include, for example, proliferation, differentiation, morphological state, motility, matrix production, and life/death. Advances in biomaterial technologies for engineering cells and their microenvironments play instrumental roles in discoveries ranging from elucidation of fundamental biological processes to translation of cellular and material systems to clinics and industry. Work in this area includes biomaterials and biomaterial systems that focus on controlling cells and their environments at the cell scale and talks will encompass engineering microenvironments, biomaterial-influenced cell signaling, technology used in stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis. Studies that will be highlighted will range from the development of biomimetic materials providing specific physicochemical cues that elicit desired phenotypic responses to work focused on applications of material systems at the cellular level, for example in cell-based and cell-focused therapies or in understanding the progression of disease, such as COVID-19.
Moderators:
Daniel Harrington, PhD
Chris Highley, PhD
Ram Saraswat, BS
Scott Wood, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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65. Hydrogel Cultures Reveal Sex Differences in Valvular Myofibroblasts with Links to Genes that Escape X-Chromosome Inactivation, Brian Aguado, PhD, Cierra Walker, Joseph Grim, Megan Schroeder, Dilara Batan, Brandon Vogt, Andrea Gonzales-Rodriguez, Donald Heistad, Leslie Leinwand, Kristi AnsethUniversity of Colorado Boulder, Boulder, CO, USA
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66. Laminin interactions with the islet in a 3d reverse thermal gel scaffold protect against cytokine-mediated ?-cell death, Meghana Shivananda Murthy, MS1,2, Nikki Farnsworth, PhD1,21Colorado School of Mines, Golden, CO, USA, 2University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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67. Investigating Overload in Triggering Hypertrophic Cardiomyopathy Pathogenesis using iPSC Cardiomyocytes, Jignxuan Guo, MS, Huanzhu Jiang, Kasoorelope Oguntuyo, Brandon Rios, Anand Boodram, Nathaniel Huebsch, PhDWashington University in St. Louis, St. Louis, MO, USA
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68. Myofibroblast persistence promotes inflammation via IL-8 secretion in valvular interstitial cells, Cierra Walker, Megan Schroeder, PhD, Leslie Leinwand, PhD, Kristi Anseth, PhDUniversity of Colorado Boulder, Boulder, CO, USA
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69. Sliding Hydrogels with Tunable Molecular Mobility Enhance Cartilage formation by Chondrocytes and Stem Cells in a dose-dependent manner, Xinming Tong, Manish Ayushman, Fan YangStanford University, Stanford, CA, USA
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70. Supramolecular Click Product Interactions Induce Dynamic Stiffening of Extracellular Matrix-Mimetic Hydrogels, Samantha Holt, Julio Arroyo, Emily Poux, Marissa Heintschel, Austen Fricks, Isabelle Agurcia, Amanda Rakoski, Daniel Alge, PhDTexas A&M University, College Station, TX, USA
Orthopaedic Biomaterials SIG 1
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Virtual
About
The Orthopaedic Biomaterials Special Interest Group is focusing on new technologies and materials advances in orthopaedic surgery. The three immediate goals of this emerging Special Interest Group are: 1) solicitation of new members for the Special Interest Group from current Society membership and from non-members actively engaged in research and development of improved materials for orthopaedics, 2) identification of key issues in orthopaedic materials that should be addressed within the Society, and 3) cooperation between Special Interest Group membership and the chairman of the Program Committee for the Annual Meeting to assist in the coordination of the scientific program
Moderators:
Tolou Shokufar, PhD
Kelvin Yeung, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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71. Multi-functional Cerium Oxide Nanoparticles Protect Against Irradiation-Induced Cellular Damage while Augmenting Osteogenesis In Vitro, Fei Wei, PhD, Craig Neal, BS, Tamil Sakthivel, PhD, Sudipta Seal, PhD, Thomas Kean, PhD, Mehdi Razavi, PhD, Melanie Coathup, PhDUniversity of Central Florida, Orlando, FL, USA
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72. Repair of Rat Calvaria Defect with Injectable Strontium (Sr2+)-Doped Polymeric Brushite Ceramics, David Markel1,2, Therese Bou-Akl1, Paula Dietz1, Bin Wu1, Tong Shi2, Paul Begeman2, Weiping Ren, PhD1,21Ascension Providence Hospital, Southfield, MI, USA, 2Wayne State University, Detroit, MI, USA
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73. Temporally Controlled Release of Periosteal Paracrine Factor Mimetics for Efficient Bone Allograft Healing: A Cell and Growth Factor Free Approach, Sayantani Basu, Ph.D., Amy Van Hove, Ph.D., Yiming Li, Ph.D., Danielle Benoit, Ph.D.University of Rochester, Rochester, NY, USA
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74. Comparison of Two Nerve Ablation Models and their Impact on Titanium Implant Osseointegration, Jingyao Deng, IV1, David Cohen, MD1, Barbara Boyan, PhD1,2, Zvi Schwartz, PhD, DMD1,31Virginia Commonwealth University, Richmond, VA, USA, 2Georgia Institute of Technology, Richmond, VA, USA, 3University of Texas Health Science Center at San Antonio, Richmond, VA, USA
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75. Microribbon-based macroporous matrices enhance cartilage repair in rat osteochondral defect model, Xinming Tong, Masahiro Maruyama, Danial Barati, Stuart Goodman, Fan YangStanford University, Stanford, CA, USA
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76. Using chemical imaging in probing spectral biomarker of pseudo-capsule macrophages in response to metal debris, Songyun Liu1,2, Deborah Hall1, Stephanie McCarthy1, Joshua Jacobs, MD1, Robin Pourzal, PhD11Rush University Medical Center, Chicago, IL, USA, 2University of Illinois at Chicago, Chicago, IL, USA
Panel: Transitioning Technology from Bench to Market
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
Track: Industry
Room: Virtual
About
Are you interested in the process of clinically translating academic research? Join us for a panel discussion with professionals in the tech transfer fields, as well as researchers that have successfully seen their research spin out into clinical products. Learn more about the translation process in general, and gain insight about best practices to keep in mind to maximize the translational potential of your future biomaterials research.
Abstracts
Abstracts will be available for download on April 20, 2021.
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Moderator(s):
Deanna Bousalis
Jason Guo
Invited Speaker(s)
Targeted and Stimuli-Responsive Biomaterials for Drug Delivery - 1
Timeslot: Wednesday, April 21, 2021 - 12:30pm to 2:00pm
About
Targeted and stimuli-responsive biomaterials, are promising for various applications in drug delivery. These "smart" materials can act rapidly at the site of interest while avoiding biological barriers, toxicity, and other potential detrimental effects. Many stimuli have been utilized to trigger stimuli-responsive materials including pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. Similarly, many targeting mechanisms ranging from passive (e.g., enhanced permeation and retention) to active targeting approaches (e.g., peptide ligands) have been integrated into targeted drug delivery systems. This session will focus on the development and use of such materials for applications including, but not limited to, cancer, infection, orthopedic diseases, cardiovascular disease, and autoimmune diseases.
Moderator:
Danielle Benoit, PhD
Abstracts
Abstracts will be available for download on April 20, 2021.
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223. Injectable Acylhydrazone Hydrogels for Sustained Protein Release, Fang-Yi Lin, PhD, Nathan Dimmitt, Chien-Chi Lin, PhDIndiana University-Purdue University Indianapolis, Indianapolis, IN, USA
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224. Polydopamine-Mesoporous Silica Core-Shell Nanoparticles for Combined Photothermal-Immunotherapy, Anushree Seth, PhD, Hamed Derami, Prashant Gupta, Zheyu Wang, Priya Gupta, Rohit Gupta, Thao Cao, Jeremiah Morrissey, PhD, Srikanth Singamaneni, PhD
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225. Hydrolytically degradable hydrogels for therapeutic delivery, Maria Coronel, PhD, Karen Martin, Rahul Shah, Andres Garcia, PhDGeorgia Institute of Technology, Atlanta, GA, USA
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226. Modular Oxygen-Generating Biomaterials for in situ Support of Cell-based Therapies, Robert Accolla1, Jia-Pu Liang1, Cherie Stabler, PhD1,21University of Florida, Gainesville, FL, USA, 2UF Diabetes Institute, Gainsville, FL, USA
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227. Ultrasound-Controlled Release of Basic Fibroblast Growth Factor (bFGF) from Acoustically-Responsive Scaffolds Improves Recovery in the Murine Model of Hind Limb Ischemia, Hai Jin1,2, Carole Quesada1, Mitra Aliabouzar1, Oliver Kripfgans1, J. Brian Fowlkes1, Renny Franceschi1, Jianhua Liu2, Andrew Putnam1, Mario Fabiilli11University of Michigan, Ann Arbor, MI, USA, 2South China University of Technology, Guangzhou, China
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228. Spatially-Directed Angiogenesis via the Ultrasound-Controlled Release of Basic Fibroblast Growth Factor (bFGF) from Acoustically-Responsive Scaffolds, Leidan Huang1,2, Carole Quesada1, Mitra Aliabouzar1, Oliver Kripfgans1, Renny Franceschi1, Zheng Liu2, Andrew Putnam1, Mario Fabiilli11University of Michigan, Ann Arbor, MI, USA, 2Second Affiliated Hospital of Army Medical University, Chongqing, China