Biomaterials for Regulating Immune Responses

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Room: Virtual

About

This session will focus on development of synthetic or natural biomaterials to regulate immune functions or modulate the metabolism of immune cells. For conditions such as autoimmune diseases, allergies, graft-versus-host disease, and hypersensitivity to biological drugs, biomaterials may offer the potential to induce antigen-specific immune tolerance through novel antigen delivery approaches, or precisely induce local immune suppression by scaffold or targeted drug delivery. Developing biomaterials that modulate the metabolism of immune cells is also an emerging field, because of the ability to selectively regulate immune responses, and provide insight into basic immune regulatory mechanisms.

Moderators:

Shijie Cao, Ph.D.
Jamal Lewis, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 133. Delivery of STING Agonist Using pBAEs Nanoparticles Inhibits Tumor Growth in Different Tumor Models, Pere Dosta Pons, PhD1,2, Alexander Cryer, PhD1,2, Santhosh Kalash, PhD1,2, Michelle Dion1,2, Shiran Ferber, PhD1,2, Natalie Artzi, PhD1,21Brigham and Women’s Hospital (Harvard Medical School), cambridge, MA, USA, 2Massachusetts Institute of Technology, Cambridge, MA, USA

  • 134. Immunoengineered CCL21 and Beta-Cell Antigen Hydrogel Platform to Induce Tolerance in Type 1 Diabetes, Flavia Zisi Tegou, MS1,2, Diana Velluto, PhD2, Freddy Gonzalez Badillo, MS1,2, Allison Bayer, PhD2,3, Silviya Zustiak, PhD4, Alice Tomei, PhD1,21University of Miami, Miami, FL, USA, 2Diabetes Research Institute University of Miami, Miami, FL, USA, 3University of Miami Miller School of Medicine, Miami, FL, USA, 4Saint Louis University, Saint Louis, MO, USA

  • 135. Succinate based Adjuvant-less Cancer Vaccine Modifies Immunometabolism and Prevent Melanoma Growth in Mice, Sahil Inamdar1, Joslyn Mangal1, Xiaojin Shi1, Marion Curtis2, Haiwei Gu1, Abhinav Acharya11Arizona State University, Tempe, AZ, USA, 2Mayo Clinic, Phoenix, AZ, USA

  • 136. Chemically-Induced Cross-linking of Peptidic Fibrils for Scaffolding Polymeric Particles and Macrophages, Jennifer Armen, BS1, Nathan Schueller2, Nevil Abraham, BS2, Ketki Velankar, MS2, Rachelle Palchesko, PhD3,4, Yong Fan, PhD5,6, Wilson Meng, PhD2,7, Ellen Gawalt, PhD1,71Duquesne University, Chemistry and Biochemistry, Pittsburgh, PA, USA, 2Duquesne University, Pharmaceutical Sciences, Pittsburgh, PA, USA, 3Carnegie Mellon University , Biomedical Engineering, Pittsburgh, PA, USA, 4University of Pittsburgh, Louis J. Fox Center for Vision Restoration, Pittsburgh, PA, USA, 5Allegheny-Singer Research Institute, Allegheny Health Network, Pittsburgh, PA, USA, 6Carnegie Mellon University, Biological Sciences, Pittsburgh, PA, USA, 7McGowan Institute for Regenerative Medicine, Pittsburgh, PA, USA

Invited Speaker(s)

Drug Delivery SIG 1

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Track: Therapeutic Delivery
Room: Virtual

About

The Drug Delivery Special Interest Group will deal with the science and technology of controlled release of active agents from delivery systems. Controlled drug release is achieved by the use of diffusion, chemical reactions, dissolutions or osmosis, used either singly or in combination. While the vast majority of such delivery devices are based on polymers, controlled release can also be achieved by the use of mechanical pumps. In a broader sense, controlled release also involves control over the site of action of the active agent, using the active agent using pro-drugs, targetable water soluble polymers or various microparticulate systems. Relevant aspects of toxicology, bioavailability, pharmacokinetics, and biocompatibility are also included.

Moderators:
Michael Mitchell, PhD
Omid Veiseh, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 139. Macrophage depletion increases target specificity of bone-targeted nanoparticles, Marian Ackun-Farmmer, Baixue Xiao, Danielle BenoitUniversity of Rochester, Rochester, NY, USA

  • 140. Scalable Parallelized Microfluidic Device for Precise RNA Lipid Nanoparticle Formulations, Sarah Shepherd, BS, David Issadore, PhD, Michael Mitchell, PhDUniversity of Pennsylvania, Philadelphia, PA, USA

  • 141. Uricase Functionalized Hydrogel for the Localized Treatment of Gout, Madeline Fuchs, Gregory Hudalla, PhD, Benjamin Keselowsky, PhDUniversity of Florida, Gainesville, FL, USA

  • 142. A Potent Branched Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing in vivo, Jilian Melamed, Khalid Hajj, Kathryn WhiteheadCarnegie Mellon University, Pittsburgh, PA, USA

  • 143. In Vitro Evaluation of a Drug-Loaded Self-Assembling Peptide Hydrogel for Treating Glioblastoma Multiforme, Alexandra Nukovic, Megan Pitz, Margaret Elpers, Sarah Wilde, Arica Gregory, Angela Alexander-Bryant, PhDClemson University, Clemson, SC, USA

  • 144. Scalable Production of pDNA/lPEI Nanoparticles via Kinetically Controlled Assembly for Gene Delivery with Enhanced Efficiency and Biocompatibility, Yizong Hu1, Il Minn, PhD1, Martin Pomper, MD, PhD1, Hai-Quan Mao, PhD21Johns Hopkins University School of Medicine, Baltimore, MD, USA, 2Johns Hopkins University, Baltimore, MD, USA|

Engineered Biomaterials for Neural Applications - 1

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Track: Sensory Biomaterials and Tissues
Room: Virtual

About

Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue with applications like in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries of the peripheral and central nervous systems spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells.

Moderators:
Sarah Stabenfeldt, PhD
Shelly Sakiyama-Elbert, PhD
Kyle Lampe, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 145. Bioengineered Tissue Mimetic Hydrogels to Study Brain Tumor Biology, Sara Pedron, PhD, Brendan HarleyUniversity of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 146. Neurotrophin-3 Loaded Hyaluronic Acid Hydrogels Promote Axonal Growth In Vitro, Pablo Ramos Ferrer, Shelly Sakiyama-ElbertThe University of Texas at Austin, Austin, TX, USA|

  • 147. Understanding the role of subcutaneous priming for improving tissue engineered scaffolds for spinal cord injury treatment, Mohammad Hamrangsekachaee, Hannah Baumann, PhD, Dipak Pukale, Leah Shriver, PhD, Nic Leipzig, PhDThe University of Akron, Akron, OH, USA|

  • 148. Guiding Oligodendrocyte Precursor Cell Fate via Urokinase Plasminogen Activator-degradable Hydrogels, Edi Meco, PhD, W. Sharon Zheng, Anahita Sharma, Kyle Lampe, PhDUniversity of Virginia, Charlottesville, VA, USA

  • 149. Combination Therapeutics for Neural Injury Using Natural-based Hydrogels and Chondroitinase ABC-Galectin-3, Nora Hlavac, PhD, Dillon Seroski, PhD, Nik Agrawal, PhD, Leilani Astrab, Gregory Hudalla, PhD, Christine Schmidt, PhDUniversity of Florida, Gainesville, FL, USA|

  • Assessing the Potential of a Decellularized Peripheral Nerve-based Hydrogel as a Spinal Cord Injury Therapeutic Delivery Vehicle Deanna Bousalis1 , Michaela McCrary1 , Nora Hlavac1 , Ashley Evering1 , Natalie Vaughn1 , Christine E. Schmidt1 . 1 J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida.

Engineering Cells and Their Microenvironments SIG - 2

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Track: Engineered Microenvironments
Room: Virtual

About

This session will focus on research that describes biomaterials-based approaches for influencing cellular behaviors and fates, which include, for example, proliferation, differentiation, morphological state, motility, matrix production, and life/death. Advances in biomaterial technologies for engineering cells and their microenvironments play instrumental roles in discoveries ranging from elucidation of fundamental biological processes to translation of cellular and material systems to clinics and industry. Work in this area includes biomaterials and biomaterial systems that focus on controlling cells and their environments at the cell scale and talks will encompass engineering microenvironments, biomaterial-influenced cell signaling, technology used in stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis. Studies that will be highlighted will range from the development of biomimetic materials providing specific physicochemical cues that elicit desired phenotypic responses to work focused on applications of material systems at the cellular level, for example in cell-based and cell-focused therapies or in understanding the progression of disease, such as COVID-19.

Moderators:
Daniel Harrington, PhD
Chris Highley, PhD
Ram Saraswat, BS
Scott Wood, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 151. Synthetic Hydrogels to Study ECM Dynamics of Intestinal Organoids, Michael Blatchley1, Arda Gunay1, Max Yavitt1, Peter Dempsey2, Kristi Anseth11University of Colorado Boulder, Boulder, CO, USA, 2University of Colorado School of Medicine, Aurora, CO, USA

  • 152. Dissecting the Microenvironmental Control of Liver Stellate Cell Epigenetics and Fibrogenic Phenotypes, Ishita Jain, Aidan Brougham-Cook, Gregory Underhill, PhDUniversity of Illinois at Urbana Champaign, Urbana, IL, USA

  • 153. Biasing Hematopoietic Response In Single-Cell Microenvironments, Aidan Gilchrist1, Julio Serrano1, Michael Hunckler2, Andres Garcia2, Brendan Harley11University of Illinois at Urbana-Champaign, Champaign, IL, USA, 2Georgia Institute of Technology, Atlanta, GA, USA

  • 154. Protease-Activatable Conjugates for Cell-Specific Targetting, Eugene Pashuck, PhD1, Samuel Rozans, Kayleigh Atanasoff, Abdul-Nafea Syed, Jake Tosh, Amanda Ferrante1Lehigh University, Bethlehem, PA, USA

  • 155. Development of an In-vitro Microphysiological Model of the Tracheal Epithelium, Solaleh Miar1, Yamuna Pillai1, Zina Helal1, Gregory R Dion2, Joo L Ong1, Rena Bizios1, Teja Guda11The University of Texas at San Antonio, San Antonio, TX, USA, 2US Army Institute of Surgical Research, San Antonio, TX, USA

  • 156. SARS-CoV-2 Spike Protein-Induced Toxicity in 3D Engineered Vascular Networks, Brett Stern, B.S., Janet Zoldan, PhDUniversity of Texas at Austin, Austin, TX, USA

Orthopaedic Biomaterials SIG 2

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Track: Musculoskeletal and Craniofacial Biomaterials
Room: Virtual

About

The Orthopaedic Biomaterials Special Interest Group is focusing on new technologies and materials advances in orthopaedic surgery. The three immediate goals of this emerging Special Interest Group are: 1) solicitation of new members for the Special Interest Group from current Society membership and from non-members actively engaged in research and development of improved materials for orthopaedics, 2) identification of key issues in orthopaedic materials that should be addressed within the Society, and 3) cooperation between Special Interest Group membership and the chairman of the Program Committee for the Annual Meeting to assist in the coordination of the scientific program

Moderators:
Tolou Shokufar, PhD
Kelvin Yeung, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 157. Magnesium cationic niche in bone tissue microenvironment facilitates intramembranous ossification, Jie Shen, PhD1,2, Kenneth Cheung, MD1,2, Kelvin Yeung, PhD1,21The University of Hong Kong, Hong Kong, Hong Kong, 2The University of Hong Kong Shenzhen Hospital, Shenzhen, China

  • 158. Multi-functional Cerium Oxide Nanoparticles Increase Osteogenesis and Deliver a Disparate but Protective Effect to Macrophages when Under Either Acute or Chronic Inflammatory Conditions In Vitro, Fei Wei, PhD, Craig Neal, BS, Tamil Sakthivel, PhD, Sudipta Seal, PhD, Thomas Kean, PhD, Melanie Coathup, PhDUniversity of Central Florida, Orlando, FL, USA

  • 159. Biomimetic Mg-Doped Type I Collagen / Hydroxyapatite Scaffold and Membrane Induces Osteogenesis in Mesenchymal Stem Cells Faster than in 2D Environment, Ava Brozovich, MPH1,2,3, Stefania Lenna, PhD2,3, Francesca Paradiso2,3,4, Stefano Serpelloni2,3,5, Patrick Mcculloch, MD3, Antonios Mikos, PhD6, Bradley Weiner, MD2,3, Francesca Taraballi, PhD2,31Texas A&M, Bryan, TX, USA, 2Houston Methodist Research Institute, Houston, TX, USA, 3Houston Methodist Hospital, Houston, TX, USA, 4Swansea University Medical School, Swansea, United Kingdom, 5Politecnico di Milano, Milan, Italy, 6Rice University, Houston, TX, USA

  • 161. Are Lymphocyte-Dominated Adverse Local Tissue Reactions Associated with a Chemical Attack on Preferential Corrosion Sites of CoCrMo Heads in MoP THA?, Deborah Hall, Stephanie McCarthy, Jennifer Wright, Mable Je, Joshua Jacobs, MD, Robin Pourzal, PhDRush University Medical Center, Chicago, IL, USA

  • 162. Would Ultrafine Grained Metallic Biomaterials Enhance Mechanical Properties of Orthopedic Implants?, Bahram Saleh, PhD1, Shaunak Kelkar2, Fumie Yusa, PhD1,3, Yohei Suzuki3, Takafumi Komatsu, PhD1,3, Katayoon Kalantari, PhD2, Hassan Serhan, PhD1, Thomas Webster, PhD21Rosies Base, Inc., Cambridge, MA, USA, 2Northeastern University, Boston, MA, USA, 3komatsu seiki kosakusho co. ltd, Suwa-City, Japan

Panel: Say What? I Should Follow a Standard? Characterizing Products for Commercialization

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Room: Virtual

About

This session will address how products are characterized during the commercialization process. Focus will be placed on the role and value of standards during product characterization and how they can accelerate development and regulation.

Abstracts

Abstracts will be available for download on April 20, 2021.

  • Moderator:

    Kris M. Kieswetter, PhD
    Carl G Simon, Jr., PhD

Invited Speaker(s)

Tissue Engineering SIG 1

Timeslot: Thursday, April 22, 2021 - 11:00am to 12:30pm
Track: Tissue Engineering and Regenerative Medicine
Room: Virtual

About

Tissue Engineering SIG is a forum to exchange information, further knowledge, and promote greater awareness regarding all aspects of the use of biomaterials to engineering tissue substitutes or to promote tissue regeneration. Of primary interest and relevance to TE SIG is the use of appropriate materials (synthetic and natural) with cells (either native or from a donor source) and/or biological response modifiers (e.g., growth factors, cytokines and other recombinant products) to replace tissue and organ functions. Particular emphasis is placed on the development of materials to better incorporate, protect, and deliver both the cells and biological response modifiers to help promote the healing and regenerative processes. The group is committed to forging interactions among basic scientists, applied scientists, engineers, clinicians, industrial members, professional societies in related fields, and regulatory groups in its efforts to expand and effectively utilize the shared knowledge base in this multidisciplinary field.

Moderators:
Jeff Jacot, PhD
Ngan Huang, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 163. Multifunctional Nanoparticles Containing SDF1-ELP and vRAGE-ELP Accelerate Diabetic Wound Healing, Hwan June Kang1, Suneel Kumar, PhD1, Biraja Dash, PhD2, Henry Hsia, MD2, Martin Yarmush, MD, PhD1, Francois Berthiaume, PhD11Rutgers University, Piscataway, NJ, USA, 2Yale School of Medicine, New Haven, CT, USA

  • 164. Development of Zonated Artificial Liver Tissue via Spatial Gene Patterning, Daniel Corbett1,2, Wesley Fabyan1,2, Bagrat Grigoryan3, Colleen O'Connor1,2, Fredrik Johansson1,2, Ivan Batalov1,2, Mary Regier1,2, Cole DeForest1,2, Jordan Miller3, Kelly Stevens1,21University of Washington, Seattle, WA, USA, 2Institute for Stem Cell and Regenerative Medicine, Seattle, WA, USA, 3Rice University, Houston, TX, USA

  • 165. FRESH 3D Bioprinting Full-Scale Collagen Constructs for Surgical Training Models, Andrew Lee, PhD1, Riley Patten1,2, Thomas Hinton, PhD11Fluidform, Inc., Acton, MA, USA, 2Tufts Universeity, Medford, MA, USA

  • 166. Tri-layered Hydrogel Scaffold for Vocal Fold Tissue Engineering, Kevin Tindell1, Michael McPhail, PhD2, Cheryl Myers, PhD2, Juergan Naubauer, PhD2, Justin Hintz, M.D2, David Lott, M.D2,3, Julianne Holloway, PhD11Arizona State Universiy, Tempe, AZ, USA, 2Mayo Clinic Arizona, Scottsdale, AZ, USA, 3Mayo Clinic Arizona - Phoenix Campus, Phoenix, AZ, USA

  • 167. 3D Printing of Click Functionalized, Peptide Patterned Scaffolds for Osteochondral Tissue Engineering, Jason Guo, PhD, Luis Diaz-Gomez, PhD, Virginia Xie, Sean Bittner, Emily Jiang, Bonnie Wang, Antonios Mikos, PhDRice University, Houston, TX, USA

  • 176. Surface Functionalized Stem Cell-Derived Extracellular Vesicles for Augmented Regenerative Repair of Vascular Elastic Matrix, SAJEESH SANKARANARAYANAN THAMPI, Phd, ANAND RAMAMURTHI, PhDLehigh University, Bethlehem, PA, USA