Biomaterials and Medical Products Commercialization SIG *BTI*

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Industry
Room: Virtual

About

B&MPC SIG members exchange ideas and experiences about the commercialization of medical products dependent upon biomaterials for utility and efficacy. Society for Biomaterials members, ranging from students to veterans in the field, will find an open forum to explore issues facing commercial biomaterials, such as regulations, patents, litigation, reimbursement for the resultant medical device, manufacturing and distribution; as well as perceptions of safety and patient benefits. Translation from development to marketing of safe and innovative medical products is challenged by the inconsistent availability of biomaterials in the shadow of these concerns, and a politically lively healthcare arena. Join the Biomaterials and Medical Products Commercialization SIG to enhance your knowledge and coping skills in the dynamic healthcare community.

Moderator:
Stephanie Steichen, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 199. Comparison of Silicone Adhesives in Skin Contact Applications: How Material Properties Influence Adhesive Performance and Wear, Stephanie Stephanie, PhD, Roger Gibas, Stacey Benemann, Sweden Yocom, MBADuPont, Midland, MI, USA

  • 200. Polyurethane Shape Memory Polymer Foams with Off-the-Shelf Physical Blowing Agents, Natalie Petryk, Anand Vakil, Mary Beth Monroe, PhDSyracuse University, Syracuse, NY, USA

  • 201. 3D printing with silicone elastomer for biomedical applications, Ke Du, Timothy Hughes, Group LeaderCSIRO, Clayton, Australia

  • 202. Absorbance Imaging and Artificial Intelligence for Assessing Quality of Manufactured Retinal Pigment Epithelium, Carl Simon, Jr., PhD1, Nicholas Schaub, PhD1, Peter Bajcsy1, Kapil Bharti2, Nathan Hotaling21National Institute of Standards & Technology, Gaithersburg, MD, USA, 2National Institutes of Health, Bethesda, MD, USA

  • 203. Incompatibility of Biocompatibility Standards for Biologically-Sourced Biomaterials, Rae Ritchie, PhD, Tami Zeigler, Joanne Kuske, Martha Spicer, Michael Hiles, PhD, Claus Soendergaard, PhDCook Biotech Inc., West Lafayette, IN, USA

  • 204. Mechanical Evaluation of Medical Grade Bioresorbable Materials for Additive Manufacturing Scaffolds, Clayton Culbreath1,2, Brian Gaerke1, Scott Taylor1,2, Seth McCullen1,2, Thompson Mefford21Poly-Med, Inc., Anderson, SC, USA, 2Clemson University, Clemson, SC, USA

Biomaterials Systems and Devices for Hemostasis, Resuscitation and Wound Care

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Cardiovascular Biomaterials
Room: Virtual

About

Hemorrhage control, hemodynamic resuscitation and spatio-temporal wound care via passive and/or bioactive mechanisms are important application areas of biomaterials-based technologies and includes external, intracavitary, and intravascular hemostats, nanoparticle/microparticle systems, artificial blood surrogates, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in such biomaterials technologies that focus on hemostasis/thrombosis, hemodynamic stabilization, tissue oxygenation and wound healing. The proposed session will invite presentations from researchers in this field that discuss design of the biomaterials systems, structure-property-function relationships, and translational visions of such technologies. Presentations focused on material considerations for microdevices for investigating hemostatic and thrombotic pathways are also of interest for this session.

Moderators:
Ashley Brown, PhD
Shaunak Pandya, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 205. Engineering a highly elastic bioadhesive hydrogel for sealing soft and dynamic tissues, Mahsa Ghovvati, Sevana Baghdasarian, Avijit Baidya, Jharana Dhal, Nasim AnnabiUniversity of California, Los Angeles, Los Angeles, CA, USA

  • 206. Role of Nitric Oxide-Releasing Glycosaminoglycans on In Vitro Wound Healing, Sara Maloney, Mark Schoenfisch, PhDUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA

  • 207. Controlled Oxygen Release to Accelerate Diabetic Wound Healing by Simultaneously Promoting Epithelialization and Angiogenesis, and Decreasing Tissue Inflammation, Ya Guan, Hong Niu, PhD, Jianjun Guan, PhDWashington University in St. Louis, St. Louis, MO, USA

  • 208. Rupture of Fibrin Clots: Structural and Thermodynamic Mechanisms, Valerie Tutwiler1,2, Farkhad Maksudov3, Rustem Litvinov1,4, John Weisel1, Valeri Barsegov31University of Pennsylvania, Philadelphia PA, PA, USA, 2Rutgers - The State University of New Jersey, Piscataway, NJ, USA, 3University of Massachusetts, Lowell, Lowell, MA, USA, 4Kazan Federal University, Kazan, Russian Federation

  • 209. Thrombin-triggered Shape Changing Nanogels for Development of Synthetic Platelets, Eunice Chee1,2, Emily Mihalko1,2, Ashley Brown, PhD1,21North Carolina State University and University of North Carolina - Chapel Hill, Raleigh, NC, USA, 2Comparative Medicine Institute, Raleigh, NC, USA

  • 210. Injury-targeted Enzyme-responsive Direct Delivery of Thrombin for Hemostatic Treatment of Coagulopathy, Aditya Girish, Ketan Jolly, Ujjal Didar Singh Sekhon, Anirban Sen GuptaCase Western Reserve University, Cleveland, OH, USA

Engineered Biomaterials for Neural Applications 2

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Sensory Biomaterials and Tissues
Room: Virtual

About

Engineered biomaterials are uniquely positioned for use in creating, testing, and regenerating neural tissue with applications like in vitro models of injury and disease, therapeutic treatments, understanding neural development, and mapping the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development through pre-clinical studies. These include big questions surrounding diseases and injuries of the peripheral and central nervous systems spanning neurons, astrocytes, oligodendrocytes, microglia, and Schwann cells.

Moderators:
Sarah Stabenfeldt, PhD
Shelly Sakiyama-Elbert, PhD
Kyle Lampe, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 211. Effect of Hyaluronic Acid Molecular Weight on Viscoelastic Properties and Glioblastoma Invasion, Emily Carvalho, Sanjay Kumar, PhD, MDUniversity of California, Berkeley, Berkeley, CA, USA

  • 212. Stabilization of Chondroitinase ABC using Single Enzyme Nanoparticles for Spinal Cord Injury Repair, Shashank Kosuri1, Heloise Mugnier1, Matthew Tamasi1, Zachary Finkel1, Isabel Perez1, Li Cai, PhD1, Rene Schloss, PhD1, Martin Yarmush, PhD1, Adam Gormley, PhD1Rutgers University, Piscataway, NJ, USA

  • 213. Human Schwann Cell Stimulation Through HA-CNT Nanofibers, Judy Senanayake, B.Tech, Harini Sundararaghavan, PhDWayne State University, Detroit, MI, USA

  • 214. Investigating Olfactory Mucosa derived Mesenchymal Stem Cells (OM-MSCs) for Peripheral Nerve Repair, Katelyn Neuman, Aidan Kenny, Ryan Koppes, PhDNortheastern University, Boston, MA, USA

  • 215. Controlling Stromal Cell-Derived Factor-1? Delivery through Norbornene Hyaluronic Acid Microgels, Kassondra Hickey, Shannon Grassi, Jaimeson Veldhuizen, Fallon Fumasi, Medhi Nikkhah, Julianne Holloway, Sarah Stabenfeldt, PhDArizona State University, Tempe, AZ, USA

Immunomodulatory Biomaterials 2

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Immunomodulatory Biomaterials
Room: Virtual

About

The session will focus on engineered biomaterials for therapeutic immune modulation. Specifically, the session will cover topics ranging from biomaterials for delivery of immunomodulators and imaging agents, scaffolds for immunomodulation, cell‐based therapies, etc. Several cutting edge immune engineering platforms will be included.

Moderator:
Ashish Kulkarni, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 218. Nanometer-Scale Assembly and High-Throughput Screening of Bispecific T Cell Engaging Cytokine (BiTEokine) Immunotherapies, Priscilla Do, PhD1, Lacey Perdue1, Curtis Henry, PhD2,3, Christopher Porter, MD2,3, Erik Dreaden, PhD1,2,31Georgia Institute of Technology, Atlanta, GA, USA, 2Emory School of Medicine, Atlanta, GA, USA, 3Winship Cancer Institute of Emory University, Atlanta, GA, USA

  • 219. Comparison of Immunoisolation Platforms for Pancreatic Islet Transplantation: Polyethylene Glycol Conformal Coating, Alginate Single and Double Capsules, Teresa De Toni1,2, Aaron Stock1,2, Floriane Devaux1, Susan Safley3, Collin Weber3, Oscar Alcazar2, Noel Ziebarth1, Peter Buchwald2,4, Alice Tomei1,21Department of Biomedical Engineering, University of Miami, Coral Gables, FL, USA, 2Diabetes Research Institute, University of Miami, Miami, FL, USA, 3Department of Surgery, Emory University, Atlanta, GA, USA, 4Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA

  • 220. Real-time Imaging of Macrophage Immunotherapy Using a Novel Nitric Oxide Nanoreporter, Anujan Ramesh1,2, Sahana Kumar2, Anthony Brouillard2, Dipika Nandi3, Ashish Kulkarni1,2,3,41University of Massachusetts, Amherst, MA, USA, 2University of Massachusetts Amherst, Amherst, MA, USA, 3UMass Amherst, Amherst, MA, USA, 4Umass, Amherst, MA, USA

  • 221. Dual Inhibition of CSF1R and MAPK Pathways Using Supramolecular Nanoparticles Enhances Macrophage Immunotherapy, Anthony Brouillard, Anujan Ramesh, Sahana Kumar, Dipika Nandi, Ashish Kulkarni, PhDUniversity of Massachusetts, Amherst, Amherst, MA, USA

  • 222. Thy-1 negative fibroblasts are an immuno-responsive subpopulation critical for biomaterial-mediated fibrosis, Daniel Abebayehu, PhD, Grace Bingham, Andrew Miller, Donald Griffin, PhD, Thomas Barker, PhDUniversity of Virginia, Charlottesville, VA, USA

Panel: Emerging Bionanomaterials and Nanotoxicity

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Room: Virtual

About

The current pandemic has reminded us the challenges and difficulties in dealing with infections and other biomedical problems. Nanomaterials have found numerous applications in the field of medicine but are not without limitations. In this panel, the emerging and advancement of new nanomaterials, nanotoxicity, and their biomanufacturing will be presented, and their roles in potential COVID-19 diagnosis, treatments, and vaccine development will be discussed. Biomaterials like peptides will be used as examples to understand and control immune responses in developing vaccines or serving as innovative new nanomaterials.

Moderators:
Bingyun Li, PhD
J. Amber Jennings, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

Invited Speaker(s)

Targeted and Stimuli-Responsive Biomaterials for Drug Delivery - 2

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Functional Biomaterials and Surfaces
Room: Virtual

About

Targeted and stimuli-responsive biomaterials, are promising for various applications in drug delivery. These "smart" materials can act rapidly at the site of interest while avoiding biological barriers, toxicity, and other potential detrimental effects. Many stimuli have been utilized to trigger stimuli-responsive materials including pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. Similarly, many targeting mechanisms ranging from passive (e.g., enhanced permeation and retention) to active targeting approaches (e.g., peptide ligands) have been integrated into targeted drug delivery systems. This session will focus on the development and use of such materials for applications including, but not limited to, cancer, infection, orthopedic diseases, cardiovascular disease, and autoimmune diseases.

Moderator:
Anita Shukla, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 229. Targeted Delivery of a TGF-? Receptor II Inhibitor Using Multifunctional Nanogels to Control Cardiac Fibrosis after Heart Failure, Yu Dang1, Hong Niu, PhD1, Zhaobo Fan, PhD2, Ya Guan1, Ning Gao1, Jianjun Guan, PhD11Washington University in St. Louis, St. Louis, MO, USA, 2The Ohio State University, Columbus, OH, USA

  • 230. Ternary Complex Nanoparticles Enable Sustained Release of Bortezomib for Local Chemotherapy of Hepatocellular Carcinoma, Yicheng Zhang, Hai-quan Mao, Yizong Hu, Ling Li, Florin SelaruJohns Hopkins University, Baltimore, MD, USA

  • 231. CD4 Targeted Nanoparticle Delivery of Eggmanone for T Cell Modulation in Autoimmunity, Christopher Haycook, MS1, Joseph Balsamo2, Evan Glass, MS1, Charles Williams, PhD3, Charles Hong, PhD3, Amy Major, PhD2, Todd Giorgio, PhD11Vanderbilt University, Nashville, TN, USA, 2Vanderbilt University Medical Center, Nashville, TN, USA, 3University of Maryland School of Medicine, Baltimore, MD, USA

  • 232. Oxidation-responsive Magnetic Nanostructure-loaded Bicontinuous Nanospheres for Drug Delivery, Mallika Modak, Sharan Bobbala, Chamille Lescott, Yu-Gang Liu, Vikas Nandwana, Vinayak Dravid, Evan ScottNorthwestern University, Evanston, IL, USA

  • 233. Nanomedicine Targeting to Activated Neutrophil-Platelet Complexes as a Novel Treatment for DVT, Anirban Sen Gupta1, Michelle Cruz1, Jurgis Alvikas2, Nicole Masters3, Kara Bane, Maria de la Fuente1, Marvin Nieman1, Keith Neeves3, Matthew Neal2, Evi Stavrou11Case Western Reserve University, Cleveland, OH, USA, 2University of Pittsburgh Medical Center, Pittsburgh, PA, USA, 3University of Colorado Denver, Anschutz Campus, Aurora, CO, USA

  • Biomimetic Fibrin-Targeted and H2O2-Responsive Nanocarriers for Thrombus Therapy Yi Zhao 1, 2 , Ruosen Xie 1, 2 , Nisakorn Yodsanit1, 2 , Mingzhou Ye 1, 2 , Yuyuan Wang, Shaoqin Gong 1, 2*

Tissue Engineering SIG - 2

Timeslot: Friday, April 23, 2021 - 11:00am to 12:30pm
Track: Tissue Engineering and Regenerative Medicine
Room: Virtual

About

Tissue Engineering SIG is a forum to exchange information, further knowledge, and promote greater awareness regarding all aspects of the use of biomaterials to engineering tissue substitutes or to promote tissue regeneration. Of primary interest and relevance to TE SIG is the use of appropriate materials (synthetic and natural) with cells (either native or from a donor source) and/or biological response modifiers (e.g., growth factors, cytokines and other recombinant products) to replace tissue and organ functions. Particular emphasis is placed on the development of materials to better incorporate, protect, and deliver both the cells and biological response modifiers to help promote the healing and regenerative processes. The group is committed to forging interactions among basic scientists, applied scientists, engineers, clinicians, industrial members, professional societies in related fields, and regulatory groups in its efforts to expand and effectively utilize the shared knowledge base in this multidisciplinary field.

Moderators:
Jeff Jacot, PhD
Ngan Huang, PhD

Abstracts

Abstracts will be available for download on April 20, 2021.

  • 234. Fabrication of Nanofiber Microspheres with Tunable Morphology via Gas Bubble-Mediated Co-axial Electrospray, Johnson John, PhD, Jingwei Xie, PhDUniversity of Nebraska Medical Center, Omaha, NE, USA

  • 235. Mechanistic study of synthesizing tunable gelatin methacrylate (GelMA) bioinks for rapid and high-resolution stereolithography bioprinting, Hitendra Kumar1,2, Kabilan Sakthivel, PhD1, Mohamed Mohamed, PhD1, Emilie Boras3, Su Ryon Shin, PhD4, Keekyoung Kim, PhD1,21The University of British Columbia Okanagan, Kelowna, BC, Canada, 2University of Calgary, Calgary, AB, Canada, 3The University of British Columbia, Vancouver, BC, Canada, 4Harvard Medical School, Cambridge, MA, USA

  • 236. Characterization of Degradation and Bioactive Growth Factor Release for 3D Printed Poly(Propylene Fumarate)-Based Constructs, Gerry Koons, Panayiotis Kontoyiannis, Mani Diba, PhD, Letitia Chim, David Scott, PhD, Antonios Mikos, PhDRice University, Houston, TX, USA

  • 237. Aptamers Assisted Controlled Growth Factor Delivery Enables Self-Organizing Microvasculature within 3D Microenvironment, Deepti Rana, Vasileios Trikalitis, Vincent R. Rangel, Jeroen Rouwkema, PhDUniversity of Twente, Enschede, Netherlands

  • 238. 3D Printed Micronized Fat-Laden Collagen Constructs for Treatment of Chronic Wounds, Trevor Schmitt1, Nathan Katz2, Vipuil Kishore11Florida Institute of Technology, Melbourne, FL, USA, 2Jointechlabs, Wheeling, IL, USA

  • 239. Zinc in Composite Scaffolds Promotes Cell Growth and Mineralized Matrix Production, Jennifer Moy, Treena Arinzeh, PhDNew Jersey Institute of Technology, Newark, NJ, USA