Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Harborside Ballroom A-B, 4th Floor
About
Treatment of microbial infections is complicated by rising antibiotic resistance and the inherent difficulty of treating biofilm-associated infections. In both scenarios, many current FDA approved antimicrobial drugs are ineffective, leading to a significant health and economic burden. Compounding these issues is a lack of development of new antimicrobial drug classes limiting the pipeline of available therapeutics. Advances in antimicrobial biomaterial therapies have the potential to improve outcomes for bacterial, fungal, viral, and biofilm-associated infections. Innovations in biomaterials are critically needed in the face of the COVID-19 pandemic, both for treatments of the SARS-CoV-2 virus, and also for effective treatment of the severe bacterial and fungal co-infections that have been reported. This session will cover biomaterials approaches to treat bacterial, fungal, and viral infections, including the prevention and eradication of biofilms. Strategies discussed may include antimicrobial surface modifications, device coatings, drug delivery, and immune engineering approaches.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 2. INVITED SPEAKER: Endowing Face Masks with Virucidal Activity via UV-Grafted Quaternized Cationic Amphiphiles, R. Helen Zha, PhD*(1), Mirco Sorci, PhD(1), Tanner Fink(1), Brigitte Arduini, PhD(1), Katharine Dovidenko, PhD(1), Vaishali Sharma(2), Sneha Singh, PhD(2), Caryn Heldt, PhD(2), Edmund Palermo, PhD(1); (1)Rensselaer Polytechnic Institute, Troy, NY, USA, (2)Michigan Tech University, Houghton, MI, USA
1:30:00 PM 3. Efficacy of saline wash plus antibiotics doped PVA composite in a mouse pouch infection model, David Markel, MD.(1,2), Therese Bou- Akl, MD., PhD.(1,2), Paula Dietz, MS.(1), Bin Wu, MD.(1), Weiping Ren, MD, PhD*(1,3); (1)Ascension Providence Hospital, Southfield, MI, USA, (2)Wayne State University, Detroit, MI, USA, (3)Virotech Co., Inc., Troy, MI, USA
1:45:00 PM 4. Antimicrobial blue light, oregano oil, and CZ gel manage Staphylococcus aureus biofilms at the skin-implant interface of percutaneous osseointegrated prosthetics in an ex vivo setup, Jemi Ong*(1), Rose Godfrey(1), Taylor Peterson(1), Josh Tam(2), Lynn Drake(2), Alexa Nazarian(2), Richard Epperson(1), Brad Issacson(3), Paul Pasquina(3), Dustin Williams(1); (1)University of Utah, Salt Lake City, UT, USA, (2)Wellman Center of Photomedicine, Boston, MA, USA, (3)Uniformed Services University, Bethesda, MD, USA
2:00:00 PM 5. New Fluorinated Polyphosphazene Biomaterials for Controlling Microbial Infections, Shelby Alwine*(1,2), Chen Chen(3), Christopher Siedlecki, PhD(2), Harry Allcock, PhD(3), Lichong Xu, PhD(2); (1)Clarkson University, Potsdam, NY, USA, (2)Penn State College of Medicine, Hershey, PA, USA, (3)The Pennsylvania State University, University Park, PA, USA
2:15:00 PM 6. Antimicrobial Effects of Piezoelectric Charges, Carolina Montoya, PhD*, Santiago Orrego, PhD, Temple University, Philadelphia, PA, USA
Invited Speaker(s)
BioInterfaces (SIG)
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Kent A-C, 4th Floor
About
The junction between materials and biological systems is a critical and complex interface with the potential to control the function of macromolecules and dictate cell and tissue responses. Increasingly, cells and biomacromolecules are designable components of biomaterials, creating additional opportunities for innovative research at the interface of materials science and fundamental biology. This session serves as a forum for advances in approaches to modulate interfacial properties, investigations of structure-function and self-assembly at biointerfaces, and applications of interface-driven biomedicine. We also encourage contributions that advance a biomaterials lens to cutting-edge research in protein and cell biology, and research that translates progress in molecular and cell biology into innovative biomaterials.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 7. INVITED SPEAKER: Xiao Huang, PhD, University of California, San Francisco, Biointerfaces SIG Rising Star Award recipient
1:15:00 PM 8. Combining Raman Spectroscopy and 3D Printing to Replicate the Enthesis Region Towards ACL Reconstruction, Nilabh Kajave*, Trevor Schmitt, Vipuil Kishore; Florida Institute of Technology, Melbourne, FL, USA
1:30:00 PM 9. Submicron Topography De- sign for Controlling Bacte- rial Adhesion and Biofilm Formation, Christopher Siedlecki, Ph.D.*, Lichong Xu, Ph.D.; Pennsylvania State University College of Medicine, Hershey, PA, USA
1:45:00 PM 10.Tuning the interfacial properties of fluorous colloids towards ultrasound programmable bioactivity., Atip Lawanprasert, B.S.*, Alda Chau, Janna Halloran, PhD, Sean Hannifin, Scott Medina, PhD, Pennsylvania State University, University Park, PA, USA
2:00:00 PM 11. Muscle-Nerve Interaction Differentially Alters Extracellular Matrix Remodeling between Two Models of Paralysis, James Redden(1)*, Jingyao Deng(1), Joshua Cohen, PhD(1), Lucas Olson(1), Barbara Boyan, PhD(1,2), Zvi Schwartz, PhD(1,3), Michael McClure, PhD(1); (1)Virginia Commonwealth University, Richmond, VA, USA (2)Georgia Institute of Technology, Atlanta, GA, USA (3)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
2:15:00 PM 12. Biodegradable Gelatin-based Edible Electronics to Diagnose Eosinophilic Esophagitis, Gaurav Balakrishnan*, Julie Shin Kim, Mia Ritter, Durva Naik, Spencer Matonis, Aditya Khair, Christopher Bettinger, Carnegie Mellon University, Pittsburgh, PA, USA
Invited Speaker(s)
Biomaterial-Tissue Interaction (SIG)
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Waterview Ballroom, Ground Level
About
The Biomaterial-Tissue Interaction SIG session will consider abstracts that investigate, in vitro and in vivo, the effects of biomaterial properties, characteristics or modifications on molecular, cellular, and physiological processes. These events initiate with specific interactions between biomaterials and biological molecules present in tissues after biomaterial implantation, followed by cell recognition and activation of cellular processes such as cell attachment, proliferation, activation, polarization, differentiation, and necrosis. Understanding these events is the purpose of the Biomaterial-Tissue Interaction (BTI) Special Interest Group.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 24. Utilization of High Dimensional Spectral Flowcytometry As A Tool For Immune Cell Characterization In Dissected Implant Tissue From Mice., Ravi Lokwani, PhD*, Tran Ngo, Kenneth Adusie, Sabrina DeStefano, Kaitlyn Sadtler, NIBIB, National Institutes of Health, Bethesda, MD, USA
1:15:00 PM 25. Histologic Profiling of Local and Systemic Immune Reaction in Mice, Tran Ngo(1), Yijun Su(2), Kaitlyn Sadtler, PhD(3), Hari Shroff(4), Harshad Vishwasrao(5), Jiamin Liu(6), Sabrina DeStefano(7)*; (1)Post baccalaureate IRTA National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (2)Special Volunteer National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (3)Principal Investigator National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (4)Employee at National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (5)Employee of National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (6)Staff Scientist National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA, (7)Post baccalaureate BESIP National Institutes of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
1:30:00 PM 26. Immune Characterization of a Microgel Composite for Tissue Remodeling, Jessica Stelzel*, Zhicheng Yao, Stuart Bauer, Sashank Reddy, Hai- Quan Mao, Joshua Doloff, Johns Hopkins University and Medicine, Baltimore, MD, USA
1:45:00 PM 27. Gamma Delta T Cells in Tissue Injury and Foreign Body Response, Anna Ruta*, Locke Davenport Huyer, PhD, David Maestas, Helen Nguyen, Kavita Krishnan, Joscelyn Mejias, PhD, Jennifer Elisseeff, PhD, Johns Hopkins University, Baltimore, MD, USA
2:00:00 PM 28. Lipid deposition profiles influence the immunogenicity of biomaterials, Christian Schreib(1)*, Maria Jarvis, PhD(1), Tanguy Terlier, PhD(1), Sudip Mukherjee, PhD(1), Jacob Goell(1), Michael Doerfert(1), Taylor Wilson(2), Brian Hanak, MD(2), Michael Diehl, PhD(1), Isaac Hilton, PhD(1), Omid Veiseh, PhD(1), (1)Rice University, Houston, TX, USA, (2)Loma Linda University Health, Loma Linda, CA, USA
2:15:00 PM 29. Elucidating the source of DAMPs in macrophage polarization in the foreign body response, Samuel Blackman(1)*, Dalton Miles(1), Sarah Calve, PhD(1,2), Stephanie Bryant, PhD(1,2); (1)Unviersity of Colorado Boulder, Boulder, CO, USA, (2)Biofrontiers Institute, Boulder, CO, USA
Biomaterials Education (SIG)
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Laurel A-B, 4th Floor
About
The Biomaterials Education SIG members' mission is to affect quality of teaching and learning through the discussion, generation and implementation of innovative ideas. Through this, they seek to advance the interests and goals of the biomaterials community by attempting to bridge the gap between classroom theory and clinical application. As the field of biomaterials rapidly evolves, so must biomaterials education. The Biomaterials Education Special Interest Group is dedicated to the belief that all members of the biomaterials community should be provided with high quality educational opportunities in a stimulating environment.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 13. Framing the Conversa- tion in Undergraduate Biomaterials Research Experiences, Karen Burg, PhD*, Timothy Burg, PhD, University of Georgia, Athens, GA, USA
1:15:00 PM 14. Developing a Biomaterials Course with Entrepreneurial Minded Learning, Katelyn Swindle-Reilly, PhD*, Meagan Ita, PhD, Gonul Kaletunc, PhD, The Ohio State University, Columbus, OH, USA
1:30:00 PM 15. Evaluating the impact of exposure to scientific role models and work- based microbadging on intent to pursue STEM careers, Duncan Davis-Hall, MS(1), Laura Farrelly(2), Melissa Risteff(2,3), Chelsea Magin, PhD(1)*; (1)University of Colorado, Denver and Anschutz, Aurora, CO, USA, (2)Couragion Corporation, Denver, CO, USA (3)MindSpark Learning, Lakewood, CO, USA
1:45:00 PM 16. Improving Student Preparedness for Entering the Workforce: A Hands-On Experience in Project Management for a Protein Engineering Class, Julie Renner, PhD*, Nuttanit Pramounmat; Case Western Reserve University, Cleveland, OH, USA
2:00:00 PM 17. Scientific presentation self-efficacy characteristics of biomedical engineering students, Jessica Jennings, PhD*, University of Memphis, Memphis, TN, USA
2:15:00 PM 18. Authentic Learning in a Tissue Engineering Lecture through Brainstorm and Evaluate SoluTions (BEST), John Clegg, Ph.D.(1), Marissa Wechsler(2)*; (1)University of Oklahoma, Norman, OK, USA, (2)University of Texas at San Antonio, San Antonio, TX, USA
Biomaterials in Engineering the Tumor Immune Microenvironment
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Laurel C-D, 4th Floor
About
Malignant cells of the tumor co-exist with non-malignant cells in a 3D space, along with structural and secreted components. Immune cells of many types such as macrophages, dendritic cells, mast cells, T-cells and more make up the tumor immune microenvironment (TIME). Biomaterials are incorporated in bioengineering the TIME for multiple purposes: (1) creating bioengineered models to further fundamental immuno-oncology studies; and (2) modulating anti-tumor immune response. Cancer-immune cell interactions in the TIME are specifically important to study for the development of immunotherapies to treat various types of cancer. Not only is engineering the TIME useful for drug discovery, it can also provide mechanistic insights into cancer-immune cell interactions within the TIME that can be used to develop targeted immuno-therapies. In this session, we will explore all aspects of biomaterials used to engineer the tumor immune microenvironment.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 19. INVITED SPEAKER: Biomaterials to model and manipulate the tumor microenvironment, Jennifer H. Elisseeff, PhD, Johns Hopkins University
1:30:00 PM 20. CD4 T cell Signal in Lymph Nodes Attenuate Response to Single and Dual B Cell Receptor Inhibitors in Lymphomas, Grazia Marsico, PhD(1)*, Karen Martin, BSc(1), Andrés García, PhD(1), Jean Koff, MD(2), Ankur Singh, Ph.D(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, Georgia, USA
1:45:00 PM 21. Engineered Models of Macrophage-Mediated Ovarian Cancer Liver Metastasis to Evaluate Nano-Immunotherapies, Sabrina VandenHeuvel(1)*, Heather Farris(1), Eric Chau(2), Biana Godin, PhD(1,2), Shreya Raghavan, PhD(1,2); (1)Texas A&M University, College Station, TX, USA, (2)Houston Methodist Research Institute, Houston, TX, USA
2:00:00PM 22. Localized Repolarization of Tumor-Associated Macrophages via Cytokine-Loaded, Injectable Cryogels, Evan Glass(1), Sydney Henriques(1)*, Sohini Roy, PhD(2), Abigail Manning(1), Benjamin Hacker(1), Christopher Haycook, PhD(1), Marjan Rafat, PhD(1), Young Kim, MD, PhD(2), Todd Giorgio, PhD(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA
2:15:00 PM 23. Rewiring the Tumor Immune Microenvironment via Immunomodulatory Injectable Nanoparticle-Based Hydrogels, Santiago Correa, PhD*, Juliana Idoyaga, PhD, Eric Appel, PhD, Stanford, Stanford, CA, USA
Invited Speaker(s)
Drug Delivery 1 (SIG)
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Harborside Ballroom D-E, 4th Floor
About
The Drug Delivery SIG session will consider abstracts that fall with the broad areas of therapeutic development, formulation, and application testing. Drug delivery from medical devices, tissue engineering scaffolds/hydrogels, films, microparticles, nanoparticles, environmentally responsive materials, and other types of biomaterial assemblies are all invited. Studies testing drug targeting, drug combinations, and drug/cell combinations are all also welcomed to submit. Drug delivery application areas of interest include but are not limited to regenerative medicine/tissue engineering, cell and tissue transplant, cardiovascular stents and other devices, cancer, microbial infection, and autoimmune diseases.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 30. INVITED SPEAKER: Search- ing an Evaluating Drug Delivery Technologies, - Vincent Ling, PhD, Takeda Pharmaceuticals
1:30:00 PM 31. Amniotic Fluid Stabilized Lipid Nanoparticles for In Utero Intra-amniotic mRNA Delivery, Kelsey Swingle(1)*, William Peranteau, MD(2), Michael Mitchell, PhD(1); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Children’s Hospital of Philadelphia, Philadelphia, PA, USA
1:45:00 PM WITHDRAWN
2:00:00 PM 33. Helper Lipid Structure Influences Protein Adsorption and Delivery of Lipid Nanoparticles to Spleen and Liver, Rakan El-Mayta*, Michael Mitchell; University of Pennsylvania, Philadelphia, PA, USA
2:15:00 PM 34. Supramolecular Assembly of Therapeutic mRNA Overcame Critical Delivery Efficiency Barrier for Biodegradable Polymer Carriers, Yizong Hu*, Stephany Tzeng, David Wilson, Jinghan Lin, Jordan Green, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA
Attachments
Invited Speaker(s)
Immunomodulatory Biomaterials 1
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Essex A-C, 4th Floor
About
This session will focus on engineered biomaterials for modulate and regulate immune functions in the settings of autoimmune diseases, allergies, transplantation, cancer immunotherapies, etc. Specifically, the session will cover topic ranging from biomaterials for drug delivery of immunomodulators and imaging agents, antigen delivery, scaffolds for immunomodulation, microbiome modulation, cell-based therapies, etc. Cutting-edge immunoengineering platforms will be included.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 35. Nanoparticle-based Immunotherapy as a Multimodal Approach to Attenuate Severe Inflammation in Sepsis, Nhu Truong(1)*, Andrea Cottingham(1), Jacob Shaw(2), Shruti Dharmaraj(1), Jackline Lasola(2), Christopher Goodis(1), Steven Fletcher(1), Ryan Pearson(1,2); (1)University of Maryland School of Pharmacy, Baltimore, MD, USA, (2)University of Maryland School of Medicine, Baltimore, MD, USA
1:15:00 PM 36. Host-guest Nanoparticle System for Therapeutic Agent Co-delivery for Nitric Oxide-Potentiation of Cancer Immunotherapy, Jihoon Kim, PhD*, Susan Thomas, PhD, Georgia Institute of Technology, Atlanta, GA, USA
1:30:00 PM 37. An Antigen-Specific Microparticle System Ameliorates Paralysis in a Mouse Model of Multiple Sclerosis, Alexander Kwiatkowski(1)*, Eric Helm(1), Joshua Stewart, PhD(1), Theodore Drashansky, PhD(1), Dorina Avram, PhD(1,2), Benjamin Keselowsky, PhD(1); (1)University of Florida, Gainesville, FL, USA, (2)Moffitt Cancer Center, Tampa, FL, USA
1:45:00 PM 38. An Anti-Phosphorylcholine Active Immunotherapy for Inflammatory Bowel Disease, Elizabeth Curvino*, Emily Roe, Helena Freire Haddad, Mia Woodruff, Nicole Votaw, PhD, Joel Collier, PhD, Duke University, Durham, NC, USA
2:00:00 PM 39. Succinate based Adjuvant-less Cancer Vaccine Modifies Immunometabolism and Prevent Melanoma Growth in Mice, Sahil Inamdar(1)*, Joslyn Mangal, Abhirami Suresh, Nathan Ng, Alison Sundem, Marion Curtis, Abhinav Acharya, (1)arizona state university, tempe, AZ, USA
2:15:00 PM 40. Regulation of Innate Inflammatory Gene Expression In Vivo Using a Library of Self-Assembled Therapeutics, Robert Oakes, PhD(1,2)*, Lisa Tostanoski, PhD(1), Senta Kapnick, PhD(1), Eugene Froimchuk(1), Sheneil Black(1), Xiangbin Zeng, PhD(1), Christopher Jewell, PhD(1,2,3,4,5); (1)University of Maryland, College Park, MD, USA, (2)United States Department of Veterans Affairs, VA Maryland Health Care System, Baltimore, MD, USA, (3)Robert E. Fischell Institute for Biomedical Devices, College Park, MD, USA, (4)University of Maryland Medical School, Baltimore, MD, USA, (5)Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA
Stimuli-Responsive Materials for Tissue Engineering and Regenerative Medicine
Timeslot: Wednesday, April 27, 2022 - 1:00pm to 2:30pm
Room: Dover A-C, 3rd Floor
About
Stimuli-responsive materials allow for localized on-demand manipulation of the cellular microenvironment, providing unique opportunities to control cell behavior and fate. These responsive material systems have shown promise for applications in tissue engineering and regenerative medicine by enabling spatiotemporally-controlled presentation of mechanical properties, chemical cues, and other microenvironmental features. A variety of triggering stimuli, both exogenous and endogenous, have been explored to control these materials including light, ultrasound, electrical stimulation, and magnetic fields, as well as temperature, pH, and various chemical stimuli. This session will highlight recent advances in the development of stimuli-responsive materials for application in tissue engineering and regeneration, including, but not limited to, scaffolds for stem cell control, materials for guiding tissue development, dynamic "4D-patterned" materials, in vitro tissue/disease models, "smart" implantable scaffolds, and stimuli-responsive drug delivery platforms.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 41. Tissues as Electrically Responsive and Programmable Biomaterials, Gawoon Shim, MSE, Isaac Breinyn, Avi Wolf, Daniel Cohen, PhD*; Princeton University, Princeton, NJ, USA
1:15:00 PM 42. Reversible Intracellular Hydrogelation to Induce Macromolecular Crowding and Control Cell Cycle Behavior, Laura Macdougall*, Timothy Hoffman, Bruce Kirkpatrick, Benjamin Fairbanks, Christopher Bowman, Sabrina Spencer, Kristi Anseth, University of Colorado Boulder, Boulder, CO, USA
1:30:00 PM 43. Photoinduced Hydrogel Network Reorganization Modulates Intestinal Organoid Shape To Direct Fate Specification, Max Yavitt(1,2)*, Michael Blatchley, PhD(1,2), Peter Dempsey, PhD(3), Kristi Anseth, PhD(1,2); (1)University of Colorado Boulder, Boulder, CO, USA, (2)BioFrontiers Institute, Boulder, CO, USA, (3)University of Colorado Anschutz Medical Campus, Aurora, CO, USA
1:45:00 PM 44. Advances in Replacement of Sutures and Surgical Glues by Switchable Electroadhesion of Polyelectrolyte Hydrogel to Animal Tissue, Leah Borden*, Srinivasa Raghavan, PhD, University of Maryland College Park, College Park, MD, USA
2:00:00 PM 45. An Ultrasound-Responsive, Spatiotemporally-Controlled Biomaterial Platform for In-vitro Modeling of Breast Cancer Progression, Katherine Huynh, B.S.*, Kylene Lowrey, BS, Sara Evans-Dutson, BS, Mithila Handu, PhD, Sean Speese, PhD, Carolyn Schutt, PhD, Oregon Health and Science University, Portland, OR, USA
2:15:00 PM 46. Strain-stiffening Zwitterionic Hydrogels, SONU KIZHAKKEPURA, PhD(1)*, Le Zhou(1), John Klier, PhD(2), Todd Emrick, PhD(1), Shelly Peyton, PhD(1); (1)University of Massachusetts Amherst, Amherst, MA, USA (2)University of Oklahoma, Norman, OK, USA