Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Essex A-C, 4th Floor
About
The Biomaterial-Tissue Interaction SIG session will consider abstracts that investigate, in vitro and in vivo, the effects of biomaterial properties, characteristics or modifications on molecular, cellular, and physiological process. These events initiate with specific interactions between biomaterials and molecules present in tissues after biomaterial implantation, followed by cell biological recognition and activation of cellular processes such as cell attachment, proliferation, activation, polarization, differentiation, and necrosis. Understanding these events is the purpose of the Biomaterial-Tissue Interaction (BTI) Special Interest Group.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 128. Injectable Biomaterials Restore Vocal Fold Biomechanics and Muscle Volume after Laryngeal Nerve Injury, Gabriela Gonzales, MS(1,2)*, Solaleh Miar, PhD(1,2), Zina Helal(1), Ronit Malka, MD(3), Gregory Dion, MD(3), Teja Guda, PhD(1); (1)The University of Texas at San Antonio, San Antonio, TX, USA, (2)Oak Ridge Institute for Science and Education (ORISE), Belcamp, MD, USA, (3)Brooke Army Medical Center, Fort Sam Houston, TX, USA
10:45:00 AM 129. . The Angiogenic Role of Hyaluronic Acid Molecular Weight in Biomaterials for Spinal Cord Repair, Josh Karam*, Breahna Singer, Christopher Anisi, Hiromi Miwa, Dino Di Carlo, Stephanie Seidlits, University of California, Los Angeles, Los Angeles, CA, USA
11:00:00 AM 130. In Vivo pO2 Assessment of Implantation sites Using Solid Probe Oxygen Imaging, Navin Viswakarma, PhD(1), Eliyas Siddiqui(1), Sonny Patel, MD(1), Safa Hameed(1), Boris Epel, PhD(2), Mrignayani Kotecha, PhD(1)*; (1)O2M Technologies,LLC, Chicago, IL, USA, (2)The University of Chicago, Chicago, IL, USA
11:15:00 AM 131. An evaluation of Wound Healing Efficacy of a Polymer-integrated Amnion Membrane Film Dressing, Bo Wang*, PhD, Medical College of Wisconsin, Wauwatosa,, WI, USA
11:30:00 AM 132. Probing the Osteoinductivity of Siloxane Containing Shape Memory Polymers, Robert Culibrk, B.S.E.(1)*, Ahmad Arabiyat, Ph.D.(1), Daniel Yeisley, B.S.(1), Felipe Beltran, PhD(2), Melissa Grunlan, PhD(2), Mariah Hahn, PhD.(1) (1)Rensselaer Polytechnic Institute, Troy, NY, USA, (2)Texas A&M University, College Station, TX, USA
11:45:00 AM 133. A Retrieval Study of the Essure® Micro Insert Female Sterilization Implant, Charley Goodwin*, Can Aslan, Jeremy Gilbert, PhD, Clemson University, Charleston, SC, USA
Biomaterials Approaches to Address Health and Healthcare Disparities
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Laurel A-B, 4th Floor
About
The unprecedented nature of the COVID-19 pandemic has reintroduced/continued the conversation about the health inequities that disproportionately affect individuals with social, economic, and/or environmental disadvantages. This session will showcase the current status and future of purposefully designed biomaterials to address both health and healthcare disparities that disproportionately affect individuals with social, economic, and/or environmental disadvantages. The session will begin with a keynote speaker addressing the importance and future of biomaterials in disparity research, followed by short oral presentations. This session will encompass a diverse portfolio of topics including (but not limited to) cheaper alternative materials for medical care in the Global South and remote areas, sex-specific cell-biomaterial interactions, the development of biomaterial in vitro models to study diseases relevant to global health, oral vaccine delivery, and the fabrication of antiviral biomaterials to combat HIV and COVID-19.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 117. INVITED SPEAKER: Edward Botchwey, Georgia Tech and Emory University
11:00:00 AM 118. Considering Ancestry: Biomaterial Model Systems of Health Disparity, Erika Moore, PhD*, University of Florida, Gainesville, FL, USA
11:15:00 AM 119. 10 Simple Rules in Biomedical Research Design to Ensure Health and Healthcare Equity, Olivia Lanier, PhD*, Mykel Green, PhD, Elizabeth Cosgriff-Hernandez, PhD, University of Texas at Austin, Austin, TX, USA
11:30:00 AM 120. Inflammatory Serum Factors from Aortic Valve Stenosis Patients Drive Sex Differences in Valve Myofibroblasts, Brandon Vogt(1,2)*, Kristi Anseth, PhD(3), Brian Aguado, PhD(1,2); (1)University of California San Diego, La Jolla, CA, USA, (2)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA, (3)University of Colorado Boulder, Boulder, CO, USA
11:45:00 AM 121. A Biosensing Platform Based on Graphene-Gold Nanoparticles for the Rapid Sepsis Diagnosis, Maha Alafeef, PhD(1,2,3)*, Dipanjan Pan, PhD(1,2,3); (1)Bioengineering Department, the University of Illinois at Urbana-Champaign, Urbana, IL, USA, (2)Departments of Diagnostic Radiology and Nuclear Medicine and Pediatrics, Baltimore, MD, USA, (3)Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Baltimore, MD, USA
Invited Speaker(s)
Biomaterials for Trauma, Surgery and Would Healing Applications 1 *BTI*
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Harborside Ballroom A-B, 4th Floor
About
Stopping bleeding (hemostasis) and providing spatio-temporal wound care via passive and/or bioactive mechanisms is an important translational area of biomaterials-based technologies and includes external, intracavitary and intravascular hemostats, dressings, powders, foams, fibers and gels. The goal of this session is to highlight recent advances in biomaterials, biosystems/microdevices and related technologies that focus on hemostasis, thrombosis, and/or wound healing. The proposed session will invite presentations from researchers in this field that emphasize biomaterials design, structure-property-function relationships, device/technology design, and relevant translation pathways. Presentations focused on material considerations for microdevices for investigating hemostatic pathways are also of interest for this session.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 122. Light-Activated Sealants for Skin Sealing and Repair, Shubham Pallod*, Deepanjan Ghosh, Russell Urie, Jordan Yaron, PhD, Michelle McBride, PhD, Shelley Haydel, PhD, Jacquelyn Kilbourne, Kaushal Rege, PhD, Arizona State University, Tempe AZ, USA
10:45:00 AM 123. Evaluation of Safety and Efficacy of Platelet-like Particles in Trauma Models, Kimberly Nellenbach, PhD(1,2)*, Seema Nandi, PhD(1,2), Emily Mihalko, PhD(1,2), Jagathpala Shetty(3), Drew Koch, DVM(2,4), Andrew Lyon, PhD(5), Lauren Schnabel, DVM(2,4), Thomas Barker(3), Ashley Brown, PhD(1,2); (1)Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill/North Carolina State University, Raleigh, NC, USA, (2)Comparative Medicine Institute, North Carolina State University, raliegh, NC, USA, (3)Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA, (4)College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA, (5)Fowler School of Engineering, Chapman University, Orange, CA, USA
11:00:00AM 124. Evaluation of Synthetic Hydrogels as Muscle Void Fillers for Delayed Treatment of Volumetric Muscle Loss, Jonathan Kulwatno, PhD(1,2), Andrew Clark, PhD(1,2)*, Connor Dolan, PhD(1,2), Sergey Kanovka(1,2), Stephen Goldman, PhD(1,2), Christopher Dearth, PhD(1,2); (1)DoD-VA Extremity Trauma and Amputation Center of Excellence, Bethesda, MD, USA, (2)Uniformed Services University of the Health Sciences, Bethesda, MD, USA
11:15:00 AM 125. ROS Degradable Polythioketal Urethane Foam Dressings Promote Porcine Ischemic Wound Repair, Parathana Patil(1), Joshua McCune(1)*, Alonda Pollins(2), Jeffery Davidson(3), Scott Guelcher(1), Craig Duvall(1); (1)Vanderbilt University, Nashville, TN, USA, (2)Vanderbilt University Medical Center, Nashville, TN, USA, (3)Vanderbilt University School of Medicine, Nashville, TN, USA
11:30:00 AM 126. A Hydrogel-Based Foam Dressing Controls Wound Infection and Provides Self-tuning Moisture Balance, Ziyang Lan, MSE(1)*, Ronit Kar(1), Erik Shoga(1), Taneidra Buie, PhD(1), Canaan Whitfield-Cargile, PhD, DVM(2), Elizabeth Cosgriff-Hernandez, PhD(1); (1)The University of Texas at Austin, Austin, TX, USA, (2)Texas A&M University, College Station, TX, USA
11:45:00 AM 127. Thread Size and Polymer Composition Of 3D Printed and Electrospun Wound Dressings Affect Wound Healing Outcomes in An Excisional Wound Rat Model, Abraham Joy(1)*, Nicholas Nun(1), Yen-Ming Tseng(1), Tanmay Jain(1), Samreen Jatana(2), Christine McDonald(2), Edward Maytin(2); (1)University of Akron, Akron, OH, USA, (2)Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Cardiovascular Biomaterials 1 (SIG)
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Kent A-C, 4th Floor
About
Cardiovascular therapies harness biomaterials for optimizing biocompatibility, releasing drugs and as scaffolds for tissue regeneration. The session will provide a forum for research on the development and assessment of cardiovascular biomaterial applications across this entire spectrum.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 134. Substrate Stiffness Modulates Endothelial Phenotypic Transition, Maedeh Zamani, PhD(1), Yu-Hao Cheng(2), Patrick Cahan(2), Ngan Huang, PhD(1); (1)Stanford University, Stanford, CA, USA, (2)Johns Hopkins University, Baltimore, MD, USA
10:45:00 AM 135. Evaluation of a Hydrogel-coated Electrospun Mesh as a Synthetic Heart Valve, Andrew Robinson(1)*, Sanchita Bhat(2), Megan Wancura(1), Sarah Jones(1), Elizabeth Cosgriff-Hernandez, PhD, Michael Sacks(1), Lakshmi Dasi(2); (1)The University of Texas at Austin, Austin, TX, USA, (2)Georgia Tech, Atlanta, GA, USA
11:00:00 AM 136. Comparison of Decellularized Left and Right Ventricle Myocardial Matrix Hydrogels and Their Effects on Cardiac Progenitor Cells, Jervaughn Hunter(1)*, Arielle Hancko(1), Preety Shakya(2), Anthony Saviola(3), Kirk Hansen, PhD(3), Michael Davis, PhD(2), Karen Christman, PhD(1); (1)University of California San Diego, La Jolla, CA, USA, (2)Georgia Institute of Technology and Emory University, Atlanta, GA, USA, (3)University of Colorado Aurora, Aurora, CO, USA
11:15:00 AM 137. Adhesive and Soft Cardiac Strain Sensor Using Catechol-bearing Hydrogels, Chenchen Mou, PhD, Jiwoo Song*, Christopher Bettinger, PhD, Carnegie Mellon University, Pittsburgh, PA, USA
11:30:00 AM 138. Evaluating poly(glycerol dodecanedioate) For Cardiovascular Repair In Porcine Pulmonary Artery, Harsha Ramaraju, PhD(1)*, Danielle Massarella(2), Courtney Wong(1), Adam Verga(1), Martin Bocks, MD(2), Scott Hollister, PhD(1); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Case Western Reserve School of Medicine, Atlanta, GA, USA
11:45:00 AM 139. A Gelatin Polyurethane Composite Electrospun Scaffold with Cardiac Tissue-Compliant Character, Yizhou Chen*, Willa Wei, Bahram Mirani, Craig Simmons, J. Paul Santerre, University of Toronto, Toronto, ON, Canada
Drug Delivery 2 (SIG)
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Harborside Ballroom D-E
About
The Drug Delivery SIG session will consider abstracts that fall with the broad areas of therapeutic development, formulation, and application testing. Drug delivery from medical devices, tissue engineering scaffolds/hydrogels, films, microparticles, nanoparticles, environmentally responsive materials, and other types of biomaterial assemblies are all invited. Studies testing drug targeting, drug combinations, and drug/cell combinations are all also welcomed to submit. Drug delivery application areas of interest include but are not limited to regenerative medicine/tissue engineering, cell and tissue transplant, cardiovascular stents and other devices, cancer, microbial infection, and autoimmune diseases.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 140. Uricase Functionalized Hydrogel for the Localized Treatment of Gout, Benjamin Keselowsky, PhD, Gregory Hudalla, PhD, Madeline Fuchs, Ryan Clark*; University of Florida, Gainesville, FL, USA
10:45:00 AM 141. Semi-Randomized Zwitterionic Peptides to Prevent Nanoparticle Fouling, Clyde Overby, III(1,2)*, Danielle Benoit, Ph.D.(1,2); (1)University of Rochester, Rochester, NY, USA, (2)University of Rochester Medical Center, Rochester, NY, USA
11:00:00 AM 142. Combination Nanomedicines for Acute Leukemia, Erik Dreaden, PhD*, Emory School of Medicine, Georgia Institute of Technology, Children’s Healthcare of Atlanta, Atlanta, GA, USA
11:15:00 AM 143. Payload Capacity and Distribution of mRNA Lipid Nanoparticles, Yizong Hu*, Sixuan Li, Jinghan Lin, Tzahuei Wang, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA
11:30:00 AM 144. Rational Design of Anti-Inflammatory Lipid Nanoparticles for mRNA Delivery, Drew Weissman, Hanwen Zhang, Xuexiang Han, Michael Mitchell*; University of Pennsylvania, Philadelphia, PA, USA
11:45:00 AM 145. Orthogonal Modes of Immunomodulatory Protein Release from Injectable Liposomal Nanocomposite Hydrogels, Santiago Correa, PhD*, Abigail Grosskopf, John Klich, Eric Appel, PhD, Stanford, Stanford, CA, USA
Engineering the Lung Microenvironment
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Laurel C-D, 4th
About
The COVID-19 pandemic has put lung health in the spotlight. Advances in biomaterial design and microfabrication offer the potential to create in vitro models of the pulmonary microenvironment. These models can be used to develop treatments for acute conditions such as COVID-19, to investigate mechanisms of chronic disease progression, for toxicology testing, and may even eliminate the need for animal experimentation in the future. This symposium will focus on the opportunities associated with using biomaterials to engineer the lung microenvironment and potential impacts on pulmonary medicine.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 146. INVITED SPEAKER: Daniel J Weiss, MD, PhD, University of Vermont
11:00:00 AM 147. Modeling Airway Dysfunction in Asthma Using Synthetic Mucus Biomaterials, Daniel Song*, Ethan Iverson, Logan Kaler, Margaret Scull, PhD, Gregg Duncan, PhD, University of Maryland, College Park, MD, USA
11:15:00 AM 148. 3D Lung Models for Studying Chronic Respiratory Diseases in vitro, Thomas Caracena, BS*, Rachel Blomberg, PhD, Chelsea Magin, PhD, University of Colorado, Denver
Anschutz, Aurora, CO, USA
11:30:00 AM 149. A 3D Multigeneration Lung Model to Study the Biofluid Mechanics of Intratracheal Drug Delivery, Hannah Combs*, Hossein Tavana, PhD, The University of Akron, Akron, OH, USA
11:45:00 AM 150. Pulmonary Arterial Fibroblast Activation in Response to Dynamic Microenvironmental Stiffness is Sex-Specific, Mikala Mueller, BS*, Chelsea Magin, PhD, University of Colorado, Denver and Anschutz Medical Campus, Aurora, CO, USA
Invited Speaker(s)
Orthopaedic Biomaterials (SIG)
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Dover A-C, 3rd Floor
About
Orthopaedic biomaterials may include all kinds of biomaterials for orthopaedic applications (e.g., bone implant/scaffold, 3D printing, drug delivery) and related biological effects. Such biomaterials may include metals, ceramics, polymers, composites, coatings, biodegradables, etc.
Abstracts
Abstracts will be available for download on April 27, 2022.
10:30:00 AM 151. In vivo Validation of a Continuous Gradient Porous Scaffold for Osteochondral Defect Repair in a Rabbit Model, Kyra Smith(1,2)*, Soheila Ali Akbari Ghavimi, PhD(2), Stephanie Logterman, MD(2), Paul Gehret(1,2), Elisa Capuana, PhD(3), Gioacchino Conoscenti, PhD(3), Valerio Brucato, PhD(3), Vincenzo La Carrubba, PhD(3), John Lawrence, MD, PhD(2), Riccardo Gottardi, PhD(1,2); (1)University of Pennsylvania, Philadelphia, PA, USA, (2)Children’s Hospital of Philadelphia, Philadelphia, PA, USA, (3)University of Palermo, Palermo, Italy
10:45:00 AM 152. Kinetics of Staphylococcus Aureus Biofilm Development on Orthopedic Bone Cements, Grahmm Funk, B.S., B.S.(1), Kara Hageman, B.S., MPH(1)*, Amanda Varner, B.S.(1), Elizabeth Menuey, PhD(2), Kathleen Kilway, PhD(2), Terence McIff, PhD, MBA(1); (1)University of Kansas Medical Center, Kansas City, KS, USA, (2)University of Missouri-Kansas City, Kansas City, MO, USA
11:00:00 AM 153. Bone Regenerative Capacity of 3D Printed Bioactive Ceramic Scaffolds Coated with Bioactive Molecule: Dipyridamole, Lukasz Witek, MSci, PhD(1,2)*, Nick Tovar, PhD, DDS(1), Bruce Cronstein, MD(3), Jacques Hacquebord, MD(3), Philipp Leucht, MD, PhD(3), Vishal Thanik, MD(3), Eduardo Eodriguez, MD, DDS(3), Paulo Coelho, DDS, PhD, MBA(1,2,3); (1)New York University, New York, NY, USA, (2)NYU Tandon School of Engineering, Brooklyn, NY, USA, (3)NYU Langone Health, New York, NY, USA
11:15:00 AM 154. In Vitro Modeling of Cathodic Voltage-Controlled Electrical Stimulation at the Bone-Titanium Interface, Eric McDermott, PhD*, Mark Ehrensberger, PhD, University at Buffalo, Buffalo, NY, USA
11:30:00 AM 155. PMMA Bone Cement-Based Chemotherapeutic Depot Enables Refilling For Customized Treatment Of Bone Cancer, Erika Cyphert, PhD*, Nithya Kanagasegar, Ningjing Zhang, Greg Learn, PhD, Horst von Recum, PhD, Case Western Reserve University, Cleveland, OH, USA
11:45:00 AM 156. Regulation of Bone Remodeling by Microstructured Titanium Surfaces via Semaphorin 3C, Jingyao Deng(1)*, Eleanor Sabalewski(1), David Cohen(1), Zvi Schwartz, PhD, DMD(1,2), Barbara Boyan(1,3); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA, (3)Georgia Institute of Technology, Atlanta, GA, USA
Panel Discussion: Biomaterials Standards: Using them, Teaching Them, and Getting Involved
Timeslot: Thursday, April 28, 2022 - 10:30am to 12:00pm
Room: Waterview Ballroom, Ground Level
About
Biomaterial science is interdisciplinary, so no scientist by themselves possesses enough background knowledge to completely understand the phenomena. In biomaterial-tissue interactions it can sometimes be difficult to interpret results at a molecular level. Many scientists tend to interpret results through their own biases even if a more accurate explanation is already available in literature. There is a growing appreciation within the field for the value of testing standards to help maximize reproducibility and interpretability; however, the methods for teaching students how to use and develop standards are still in their nascency. This panel will facilitate a vibrant discussion of how best to actively find, use, and develop educational modules for teaching standards and other methods to maximize reproducibility in preclinical biomaterials research. Panelists will be included representing viewpoints from academic instructors, industry members, standards/regulatory agency personnel, and students.
Abstracts
Abstracts will be available for download on April 27, 2022.
Liisa Kuhn, PhD, University of Connecticut Health Center
10:45:00 AM Ryan M. Bock, SINTX Technologies
Joel D. Bumgardner, PhD, The University of Memphis
11:15:00 AM James J. Hickman, University of Central Florida