Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Dover A-C, 3rd Floor
About
Biomaterials research to address problems in the area of women's and children’s health remains underserved, requiring further attention from the scientific community to advance progress in this field. Women’s and children’s health requires a physiologically appropriate approach in the research and development of devices and medical therapies. These requirements are unique and do not lend themselves well to simply adapting those initially designed for adult males, which innovations in biomaterials can address. This session explores research into medical devices, therapeutics, and drug delivery systems specifically targeting the women’s and child health patient population, from research innovation, through prototypes to clinical delivery. This session will stimulate discussion in areas including but not limited to pelvic floor disorders, breast reconstruction, reproductive health and contraception, new fertility treatments, maternal-fetal interface models, and more. The ability to achieve the “bench to bedside” requires a thorough understanding of regulatory requirements for devices, therapeutics and biologics. This session seeks to include discussion on the processes of innovation, development and full clinical implementation to achieve impactful changes in women’s and children’s health
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 157. Fetal Biodistribution of Poly(amine-co-es- ter)-Polyethylene Glycol Nanoparticles for In Ute- ro Gene Therapy, Anna Lynn*, Jinal Pothupitiya, PhD, David Eaton, David Stitelman, MD, Peter Glazer, MD, PhD, W. Mark Saltzman, PhD, Yale University, New Haven, CT, USA
1:15:00 PM 158. Extracellular Matrix-Se- questering and Adhesion Peptide Localization Pro- motes Primordial Follicle Development In Vitro for Fertility Preservation, Ari- ella Shikanov, PhD(1)*, Claire Tomaszewski(1), Daniel Matera, Brendon Baker, PhD(1); (1)University of Michigan, ann arbor, MI, USA
1:30:00 PM 159. Self-fitting Vaginal Stents from Biodegradable, Shape Memory Polymers, Advika Kamatar(1), Andrew Robinson(1), Courteney Roberts(2), Felipe Beltran(2), Jennifer McCracken(3), Julie Hakim(3), Melissa Grunlan(2), Elizabeth Cosgriff-Hernandez(1)*; (1)The University of Texas at Austin, Austin, TX, USA, (2)Texas A&M University, College Station, TX, USA, (3)Baylor College of Medicine, Houston, TX, USA
1:45:00 PM 160. Hormone-Responsiveness of an Endometrial Perivascular Niche in Gelatin Hydrogels, Samantha Zambuto, ScM(1)*, Cody Crosby, PhD(2), Kathryn Clancy, PhD(1), Janet Zoldan, PhD(2), Brendan Harley, PhD(1); (1)University of Illinois at Urbana-Champaign, Urbana, IL, USA, (2)University of Texas at Austin, Austin, TX, USA
2:00:00 PM 161. PEG-PLGA Nanoparticle Distribution in Pregnant Mice Following Vaginal Delivery, N’Dea Irvin-Choy(1)*, Katherine Nelson(1), Jason Gleghorn(1), Emily Day(1,2); (1)University of Delaware, Newark, DE, USA, (2)Helen F. Graham Cancer Center and Research Institute, Newark, DE, USA
2:15:00 PM 162. AMPWIN: Advanced Manufacturing Processes for Women, Infants and Neonatal Health, Henry Forer*, Susan Gilmour, MD, MSc, Robert Burrell, PhD, University of Alberta, Edmonton, AB, Canada
Biomaterial-Based In Vitro Cancer/Tumor Models for Drug Screening and Diagnostics
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Harborside Ballroom A-B, 4th Floor
About
Biomaterial-based in vitro cancer/tumor models offer a close mimic of the complex tumor microenvironment, providing versatile platforms for drug and toxicology screening as well as diagnostics. The implementation of these preclinical tools can afford low-cost, easy-to-use systems to evaluate cancer treatments, enhancing the efficacy and toxicological assessment for specific patients, mitigating the limitations of current technologies, and expanding the treatment options and patient’s quality of life.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 163. INVITED TALK: Tissue engineered organoid models for under- standing longitudinal response to therapy, Alison McGuigan, PhD, University of Toronto
1:30:00 PM 164. Engineering Lung Carcinogenesis Models with Hydrogel-em- bedded Precision-cut Lung Slices, Rachel Blomberg*, Kayla Sompel, Alex Smith, Meredith Tennis, Chel- sea Magin, University of Colorado Denver
Anschutz, Aurora, CO, USA
1:45:00 PM 165. 3D Engineered Prostate Cancer Tissues for in vitro Investigation of Fibroblast Impact on CRPC and ADPC, Nicole Habbit(1)*, Benjamin Anbiah(1), Joshita Suresh(1), Yuan Tian(1), Luke Anderson(1), Megan Davies(1), Iman Hassani(1), Taraswi Mitra Ghosh(1), Balabhaskar Prabhakarpandian, PhD(2), Robert Arnold, PhD(1), Elizabeth Lipke, PhD(1); (1)Auburn University, Auburn, AL, USA, (2)CFD Research Corporation, Huntsville, AL, USA
2:00:00 PM 166. Glioblastoma spheroid responsiveness to chemotherapeutics is influenced by the stiffness of its microenvironment, Joseph Bruns, Silviya Zustiak*, Saint Louis University, Saint Louis, MO, USA
2:15:00 PM 167. Dynamic Tuning of Hydrogel Stiffness & Viscoelasticity to Probe Pancreatic Ductal Adenocarcinoma Cell Behavior, Han Nguyen(1)*, Chien-Chi Lin(2); (1)Purdue University, West Lafayette, IN, USA, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA
Invited Speaker(s)
Biomaterials for Organoids
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Essex A-C, 4th Floor
About
Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. Organoids bridge a gap in existing model systems by providing a more stable system amenable to extended cultivation and manipulation while more representative of in vivo physiology. This session will cover the most recent advancements of biomaterials-mediated organoid and tissue chip technologies in regenerative medicine, cancer therapy, drug testing, environmental control, monitoring, adaptive sensing, and translational applications. This topic was well-received in the 2021 SFB meeting and is an exciting emerging research area. In 2022, we will continue this session and promote translational research to biomaterials-mediated organoid projects' commercial viability.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 168. Tissue-Engineered Blood-Brain Barrier Model to Study Dys- functional Effects of Oxidative Stress, Tracy Chung*, Raleigh Linville, PhD, Zhaobin Guo, PhD, Robert Ye, Ria Jha, Peter Searson, PhD, Johns Hopkins University, Baltimore, MD, USA
1:15:00 PM 169. In Situ Super-Resolution Imaging of Organoids and Extracellular Matrix Interactions via Photo- expansion Microsco- py, Michael Blatchley, PhD(1)*, Arda Günay, PhD(1), Max Yavitt(1), Elijah Hawat(1), Peter Dempsey, PhD(2), Kristi Anseth, PhD(1); (1)University of Colorado - Boulder, Boulder, CO, USA, (2)University of Colorado School of Medicine, Aurora, CO, USA
1:30:00 PM 170. Pancreatic organogenesis in PEG-based synthetic hydrogels, Matthew Arkenberg, MS(1)*, Chien- Chi Lin, PhD(2); (1)Purdue University, West Lafayette, IN, USA, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA
1:45:00 PM 171. Aged B Cell Immune Organoid to Study Antigen and Ajuvant Efficacy, Zhe Zhong(1)*, Ankur Singh(1,2); (1)Georgia Institute of Technology, Atlanta, GA, USA, (2)Emory University, Atlanta, GA, USA
2:00:00 PM 172. A Biofunctionalized Hydrogel Improves Representative Features of Cortical Brain Organoid Models, Kylie Balotin*, Lauren Drake, Neelansh Bute, Allison Bosworth, PhD, Brian O’Grady, PhD, Ethan Lippmann, PhD, Vanderbilt University, Nashville, TN, USA
2:15:00 PM 173. Establish Structure-Function Correlation for Geometrically Templated Cardiac Organoids Using Artificial Intelligence, Plansky Hoang, Andrew Kowalczewski, Shiyang Sun, Zhen Ma*, Syracuse University, Syracuse, NY, USA
Black & LatinX Voices in Biomaterials
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Laurel C-D, 4th Floor
About
The purpose of this session is to highlight the research conducted by biomaterials scientists and engineers from historically excluded groups and marginalized communities, including but not limited to Black/African American, Hispanic/Latinx, and Native/Indigenous groups.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 174. INVITED TALK: Manu O. Platt, PhD, Coulter Dept. of Biomedical Engi- neering at Georgia Tech and Emory University (30 Minutes)
1:30:00 PM 175. Antimicrobial Effects of Piezoelectric Charges, Carolina Montoya, PhD*, Santiago Orrego, PhD, Temple Universi- ty, Philadelphia, PA, USA
1:37:00 PM 176. Serologic Cross-Reactivity of SARS-CoV-2 with Bat Coronavirus in Cambodia, Andrea Lucia Alfonso, B.S.(1)*, Parinaz Fathi, PhD(1), Zoe Putman(2), Mattew Drew(2), Dominic Esposito, PhD(2), Luiz Fabiano Oliveira, PhD, MD(3), Jessica Manning, MD(3), Kaitlyn Sadtler, PhD(1); (1)National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA, (2)Frederick National Laboratory for Cancer Research, Frederick, MD, USA, (3)National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Phnom Penh, Cambodia
1:43:00 PM 177. A Lysyl Oxidase Responsive Peptide Brush Polymer for Targeting Myocardial Infarction, Joshua Mesfin(1,2)*, Mary Cassidy(3), John-Paul Pham(1,2), Colin Luo(1,2), Nathan Gianneschi(3), Karen Christman(1,2); (1)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA, (2)UC San Diego, La Jolla, CA, USA, (3)Northwestern University, Evanston, IL, USA
1:49:00 PM 178. Fusogenic Peptide-Mediated Delivery of siRNA in vivo to Treat Ovarian Cancer, Timothy Samec, Kharimat Alatise*, Jessica Boulos, Carleigh Coffin, Serena Gilmore, Anthony Hazleton, Angela Alexander-Bryant, Clemson University, Clemson, SC, USA
1:55:00 PM 179. Infusible Extracellular Matrix Derived Biomaterial Promotes Vascular Integrity After Traumatic Brain Injury, Miranda Diaz(1,2)*, Rebecca Kandell(1,2), Karen Christman, PhD(1,2), Ester Kwon, PhD(1,2); (1)University of California, San Diego, La Jolla, CA, USA, (2)Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA
2:01:00 Pm 180. Protein Hydrophilicity Regulates Mechanical Properties in Engineered Hydrogels, Renato Navarro, PhD*, Michelle Huang, Julien Roth, Kelsea Hubka, PhD, Chris Long, Annika Enejder, PhD, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA
2:07:00 PM 181. Control of Redox Diffusion-Mediated Crosslinking for Conformable Hydrogel Coatings, Abbey Nkansah*, Megan Wancura, Andrew Robinson, Elizabeth Cosgriff-Hernandez, PhD, University of Texas at Austin, Austin, TX, USA
2:13:00 182. Pro-fibrotic biomaterials implanted after injury skew local and systemic monocyte expression profiles, Joshua Hooks, PhD*, Kavita Krishnan, Patricia Mensah, Christopher Cherry, PhD, Jin Han, PhD, Jennifer Elisseeff, PhD, Johns Hopkins School of Medicine, Baltimore, MD, USA
2:19:00 PM 183. Orthogonal Modes of Immunomodulatory Protein Release from Injectable Liposomal Nanocomposite Hydrogels, Santiago Correa, PhD*, Abigail Grosskopf, John Klich, Eric Appel, PhD, Stanford, Stanford, CA, USA
2:25:00 PM 184. Immunomodulation in Volumetric Muscle Loss Repair Via a Microporous Scaffold, Areli Rodriguez*, Donald Griffin, George Christ, University of Virginia, Charlottesville, VA, USA
Invited Speaker(s)
Cardiovascular Biomaterials 2 (SIG)
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Kent A-C, 4th Floor
About
Cardiovascular therapies harness biomaterials for optimizing biocompatibility, releasing drugs and as scaffolds for tissue regeneration. The session will provide a forum for research on the development and assessment of cardiovascular biomaterial applications across this entire spectrum.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 185. Fabrication and Characterization of Cardiac-Specific Extracellular Matrix Scaffolds, Wenkai Jia, PhD(1), Dhavan Sharma(1), Guifang Wang, PhD(1), Jianhua Zhang, PhD(2), Timothy Kamp, MD, PhD(2), Feng Zhao, PhD(1)*; (1)Texas A&M University, College Station, TX, USA, (2)University of Wisconsin-Madison, Madison, WI, USA
1:15:00 PM 186. Biomaterial Stem Cell Encapsulation Sup- ports Cardiomyocyte Differentiation with Improved Functionality in Suspension Culture, Mohammadjafar Hashemi*, Ferdous Finklea, Yuan Tian, Ravi Nataraj, Katherine Wright, Hanna Hammons, Elizabeth Lipke, Auburn University, Auburn, AL, USA
1:30:00 PM 187. Hydrogel Microspher- oids with Controlled Size and Aspect Ratio Support Stem Cell Cardiac Differentiation with Geometry-dependent Cardiomyocyte Structural Maturation, Mohammadjafar Hashemi*, Ferdous Finklea, Yuan Tian, Nathan Young, Selen Cremaschi, Elizabeth Lipke, Auburn Univer- sity, Auburn, AL, USA
1:45:00 PM 188. Engineering Hierarchical Vascular Chimeras by Combining Human Microvessels with Explanted Murine Vessels, Emily Margolis, MSE*, Lucia Choi, Nicole Friend, MSE, Andrew Putnam, PhD, University of Michigan, Ann Arbor, MI, USA
2:00:00 PM 189. Optimizing Vascularization in 3D Bioprinted Constructs with Computational Modeling, Nicholas Huynh, Briana Edwards, Vladislav Bukshtynov, PhD, Chris Bashur, PhD*, Florida Institute of Technology, Melbourne, FL, USA
2:15:00 PM 190. Aligned Elastic Polyurethane/Extracellular Matrix Nanofibers for Cardiomyocyte Culture, Alan Taylor*, Jiazhu Xu, Huikang Fu, Lia Molina Cortez, Sara McMahan, Ph.D, Yan Chang, Ph.D, Zui Pan, Ph.D, Jun Liao, Ph.D, Yi Hong, Ph.D, University of Texas at Arlington, Arlington, TX, USA
Dental/Craniofacial Biomaterials (SIG)
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Laurel A-B, 4th Floor
About
The Dental/Craniofacial Materials SIG session focuses on the basic, applied, and clinical research of innovative biomaterials ranging from synthetic to biological origins. These bio-inspired materials are designed to repair dental/ craniofacial tissue structures, restore their functions, and/or regenerate these tissues using tissue engineering approaches. Recent advances in dental biomaterial technologies include advanced bio-inspired inorganic, organic, and composite nanomaterials, controlled drug delivery strategies, surface modification, and 3D printing technology.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 191. Quantitative 3D Imaging of the Stem Cell-Neurovascular Niche During Cranial Bone Regeneration, Alexandra Rindone*, Allison Horenberg, Alexander Perdomo-Pantoja, MD, Timothy Witham, MD, Warren Grayson, PhD, Johns Hopkins University School of Medicine, Baltimore, MD, USA
1:15:00 PM 192. In Vivo Biocompatibility and Craniofacial Bone Regenerative Potential of Collagen and Elas- tin-based Composites, Pallabi Pal, PhD, Michelle Tucci, PhD, Lir-Wan Fan, PhD, Su- sana Salazar Marocho, PhD, Amol Janorkar, PhD*, University of Mississippi Medical Center, Jackson, MS, USA
1:30:00 PM 193. Basement Mem- brane-derived Peptide Nanocoatings Promote Junctional Epitheli- um-like Keratinocyte Function, Nicholas Fischer, PhD(1)*, Alexandra Kobe(1), John Pizarek, DDS(1), Jiahe He(1), David De Jong(1), Conrado Aparicio, PhD(1,2); (1)University of Minnesota, Minneapolis, MN, USA, (2) Universitat Internacional de Catalunya, Barcelona, Spain
1:45:00 PM 194. Corrosion and Fretting Corrosion Properties of Additively Manufactured Dental CoCrMoW Alloys, Annsley Mace*, Jeremy Gilbert, PhD, Clemson University - Medical University of South Carolina, Charleston, SC, USA
2:00:00 PM 195. Wettability after Dielectric Barrier Discharge Plasma in Vacuum Increases Osseointegration, Michael Berger(1)*, Michael Levit(1), David Cohen, MD(1), Barbara Boyan, PhD(1,2), Zvi Schwartz, DMD,PhD(1,3); (1)Virginia Commonwealth University, Richmond, VA, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA, (3)University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
2:15:00 PM 196. Characterization and Failure Analysis of a Novel Biomimetic Electrospun Membrane for GTR/GBR Applications, Lohitha Kalluri(1)*, Jason Griggs, PhD, FADM(1), Amol Janorkar, PhD(1), Ravi Chandran, DMD, PhD, FACS(1), Xiaoming Xu, PhD(2), Yuanyuan Duan, BDS, MS, PhD(1); (1)University of Mississippi Medical Center - School of Dentistry, Jackson, MS, USA, (2)Louisiana State University Health Sciences Center- School of Dentistry, New Orleans, LA, USA
Immunomodulatory Biomaterials 2
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Harborside Ballroom D-E, 4th Floor
About
This session will focus on engineered biomaterials for modulate and regulate immune functions in the settings of autoimmune diseases, allergies, transplantation, cancer immunotherapies, etc. Specifically, the session will cover topic ranging from biomaterials for drug delivery of immunomodulators and imaging agents, antigen delivery, scaffolds for immunomodulation, microbiome modulation, cell-based therapies, etc. Cutting-edge immunoengineering platforms will be included.
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM 197. Nanoparticle-Medi- ated Genetic Repro- gramming of Merkel Cell Carcinoma Leads to Immune Activation and Targeted Cancer Cell Killing in Vitro, Kathryn Luly, BS*, Jordan Green, PhD, Stephany Tzeng, PhD, Joel Sunshine, MD, PhD, Johns Hopkins University School of Medicine, Baltimore, MD, USA
1:15:00 PM 198. Multispectral Flow Cytometry Immune Response Characterization of ECM Scaffold Modified with STING Agonist, Rohan Chaudhari*, Matthew Wolf, PhD., Sanjay Pal, PhD., National Institute of Cancer, Frederick, MD, USA
1:30:00 PM 199. Modulating the Biologic Scaffold Immune Microenvi- ronment with STING Agonists, Sanjay Pal, PhD*, Brenna Hill, PhD, Rohan Chaud- hari, BS, Matthew Wolf, PhD, National Cancer Institute, Frederick, MD, USA
1:45:00 PM 200. Supramolecular Nanotherapeutics Enables Metabolic reprogramming of Tumor Associated Macrophages to Inhibit Tumor Growth, Anujan Ramesh*, Vaishaliv Malik, Ashish Kulkarni, University of Massachusetts Amherst, Amherst, MA, USA
2:00:00 PM 201. Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Allograft Rejection, Russell Urie, PhD*, Aaron Morris, PhD, Diana Farris, Elizabeth Lombard, Jun Li, PhD, Daniel Goldstein, MD, Lonnie Shea, PhD, University of Michigan, Ann Arbor, MI, USA
2:15:00 PM 202. Rescue of Dendritic Cell Metabolism from Glycolysis Inhibition for Cancer Immunotherapy, Sahil Inamdar(1)*, Joslyn Mangal, Abhirami Suresh, Nathan ng, Alison Sundem, Marion Curtis, Abhinav Acharya, (1)Arizona State University, Tempe, AZ, USA
Leveraging Advanced Biomaterials for Infectious Diseases
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Falkland Room, 4th Floor
Abstracts
Abstracts will be available for download on April 27, 2022.
1:00:00 PM WITHDRAWN
1:30:00 PM 204. Commercialization of the Seraph 100 Blood Filter: Ten Years of Push Back, Then a Pandemic, Robert Ward, NAE, BS ChE, PhD (h.)*, Keith McCrea, Ph.D, Robert Ward, B.S., Exthera Med- ical Corporation, Martinez, CA, USA
2:00:00 PM 206. Effect of Mechanical Environment on Staphylococcal Adhesion and Biofilm Formation, Alexander Tatara, MD, PhD(1,2,3)*, Michael Super, PhD(2), Sandra Nelson, MD(1), David Mooney, PhD(2,3); (1)Massachusetts General Hospital, Boston, MA, USA, (2)Wyss Institute for Biologically Inspired Engineering, Boston, MA, USA, (3)Harvard University John A. Paulson School of Engineering and Applied Sciences, Boston, MA, USA
Panel Discussion: Tips and tricks for translating academic technologies into commercial products
Timeslot: Thursday, April 28, 2022 - 1:00pm to 2:30pm
Room: Waterview Ballroom, Ground
About
This is an interactive panel that includes representation from companies (large and small), regulatory affairs, and investors spanning a broad range of biomaterials applications (drug delivery, ophthalmic biomaterials, nanomaterials, tissue engineering, etc.). Panelists will discuss challenges with translating academic technologies to viable commercial products, particularly issues associated with de-risking and translating basic research. Discussion will also include how biomaterials products and technologies are valued, including considerations of reimbursement rates. The balance and trade-offs between innovation and translational value will be highlighted as well as the challenges associated with the sometimes divergent values and priorities of academia versus industry.
Abstracts
Abstracts will be available for download on April 27, 2022.
Amelia Zellander, PhD, BioLattice
Henry Brem, Johns Hopkins University SOM
Kwame Ulmer, Wave- maker Three-Sixty Health
G Lawrence Thatcher, TESco Associates