Biomaterials for Regenerative Engineering 3

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Harborside Ballroom A-B, 4th Floor


Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials and approaches for the regeneration of tissues through a convergence of engineering, medicine, developmental biology, and stem cell science. This symposium will highlight recent trends in developing functional biomaterials that play an active role in controlling cellular behaviors and tissue regeneration. We will include different classes of biomaterials such as proteins, polysaccharides, synthetic polymers, fibers, metals, ceramics, and hydrogels for applications in regenerative engineering. This session will also highlight the biomaterials that can direct cell fate and promote differentiation. Moreover, the biomaterials that can facilitate drug delivery and immunomodulation will be covered through oral and poster presentations. During the symposium, translational strategies for handling these biomaterials from ‘Bench to Bedside’ will also be addressed. We expect that our interdisciplinary session, including material science, chemistry, biology, engineering, and medicine, will be of great significance to clinicians, industry members, and academia.


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 PM 277. Differential Proteomic Adaptation in Advanced Age and Senescence Informs Biomaterial Design for Cartilage Repair, Alexander Chin, Ph.D.(1)*, Jin Han(1), Cristina Clement(2), Hong Zhang(1), Ok Hee Jeon(3), Jennifer Elisseeff(1), Laura Santambrogio(2); (1)Johns Hopkins Medical Institutions, Baltimore, MD, USA, (2)Weill Cornell Medicine, New York, NY, USA, (3)Korea University College of Medicine, Seoul, Republic of Korea

  • 1:45:00 PM 278. Heparin-Affinity-Based IL-4 Delivery to Modulate Macrophage Polarization and Promote Vascular Regeneration, Fan Zhang, Grad Student(1)*, Martin King, Professor(1,2); (1)North Carolina State University, Raleigh, NC, USA, (2)Dong- hua University, Shanghai, China

  • 2:00:00 PM 279. Semi-synthetic Hyaluronic Acid Hydrogels Promote Muscle Regeneration by Inducing BAT Differentiation of FAPs, Anouk Killaars(1)*, Derek Ning(1), Michael Davies(2), Anthony Nguyen(2), Prashant Nuthalapati(2), Mengyao Liu(2), Xuhui Liu(2), Brian Feeley, Kevin Healy(1); (1)University of California, Berkeley, Berke- ley, CA, USA, (2)University of California, San Francisco, San Francisco, CA, USA

  • 2:15:00 PM 280. Immunomodulation in Volumetric Muscle Loss Repair Via a Microporous Scaffold, Areli Rodriguez*, Donald Griffin, George Christ, University of Virginia, Charlottesville, VA, USA

  • 2:30:00 PM 281. Injectable Extracellular Matrix Hydrogel Mediates Reduction of Tongue Fibrosis, Emma Zelus*, Marianna Alperin, MD, MS, Andrew Vahabzadeh-Hagh, MD, Karen Christman, PhD, University of California, San Diego, La Jolla, CA, USA

  • 2:45:00 PM 282. Extracellular Matrix Nanoparticles Modulate Response to Lipopolysaccharide-Induced Lung Injury, Casie Slaybaugh*, Patrick Link, PhD, Rebecca Heise, PhD, Virginia Commonwealth University, Richmond, VA, USA

  • 3:00:00 PM 283. Design and Validation of a Resorbable Vascular Graft Prepared by Metal Ligand Chelation, Ying Chen*, Anthony D’Amato, Yadong Wang, Meinig School of Biomedical Engineering, College of Engineering, Cornell University, Ithaca, NY, USA

  • 3:15:00 PM 284. Anisotropic Rod-Shaped Particles Influence Granular Hydrogel Porosity and Cell Invasion, Taimoor Qazi, Jingyu Wu, Daeyeon Lee, David Issadore, Jason Burdick, University of Pennsylvania, Philadelphia, PA, USA

Biomimetic Hydrogels for Drug Delivery and Tissue Engineering Applications 2

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Essex A-C, 4th Floor


Biomimetic materials draw inspiration from nature for their structure and properties. This session will focus on drug delivery and tissue engineering scaffolds that incorporate bioinspired components for scaffold physical or biological properties. We are soliciting abstracts on research that involves synthetic materials that mimic natural materials or that follow a design motif derived from nature.


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 PM 285. Viscoelastic Supramolecular Hyaluronic Acid Hydrogels as Phototunable Cellular Microenvironments, Fei Fan*, Bo Su, Matthew Webber, Donny Hanjaya-Putra, University of Notre Dame, Notre Dame, IN, USA

  • 1:45:00 286. Biomimetic Supramolecular Drug Delivery Hydrogels for Accelerated Skin Tissue Regeneration, Sang Hoong Jeong, Ph.D Candidate*, Sei Kwang Hahn, Professor, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea

  • 2:00:00 PM 287. Protein Hydrophilicity Regulates Mechanical Properties in Engineered Hydrogels, Renato Navarro, PhD*, Michelle Huang, Julien Roth, Kelsea Hubka, PhD, Chris Long, Annika Enejder, PhD, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA

  • 2:15:00 PM 288. Building Hierarchical Structure into Engineered Extracellular Matrices with Biomimetic Peptoids, Logan Morton*, David Castilla Casadiego, PhD, Ajay Palmer, Adrianne Rosales, PhD, University of Texas at Austin, Austin, TX, USA

  • 2:30:00 PM 289. Secretion-Assisted Assembly of Silk Peptides Produced from Bacillus, Qi Xie*, Stephen Fried, Johns Hopkins University, Baltimore, MD, USA

  • 2:45:00 PM 290. One-pot Formation of Biomimetic Interpenetrating Network Hydrogels for Processing with Stereolithography, Abhishek Dhand*, Jonathan Galaragga, Matthew Davidson, Ryan Locke, Robert Mauck, Jason Burdick, University of Pennsylvania, Philadelphia, PA, USA

  • 3:00:00 PM 291. Surface functionalization of biomimetic substrates for enhanced mechanical and cellular behavior, Anne Brooks*, Ning Zhang, PhD, Vamsi Yadavalli, PhD, Virginia Commonwealth University, Richmond, VA, USA

  • 3:15:00 PM 292. The Effect of Primary Sequence and Formation Method on Self-Assembling Peptide Structures, Megan Pitz*, Angela Alexander-Bryant, PhD, Clemson University, Clemson, SC, USA

Characterization of Materials for Regulatory Submissions

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Laurel A-B, 4th Floor


As the need for commercially-viable biomaterials grow so does an emphasis on characterization, evaluation, and commercial-scale manufacturing. Designing and developing novel biomaterials with commercial viability in mind from the beginning is key in successfully bringing materials to market. This session will highlight novel characterization approaches as well as discuss current practices in biomaterial evaluations. Presentations will also focus on material evaluation for regulatory submissions and methods of commercial-scale manufacturing. This topic would be helpful for researchers who are interested in developing their materials/devices for translational applications. We will discuss how to translate innovative research into commercial viability with a focus on: • Characterization methods for novel materials • Discussion of current regulatory approaches • Designing materials with the end goal of commercialization


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 293. Development of Bone Slice Model to Screen Particulate Implant Materials for Osteolytic Potential, Nicholas A. Hodges(1)*, Jan P. Stege- mann(2), Eric M. Sussman(1); (1) Center for Devices and Radiological Health, FDA, Silver Spring, MD, USA, (2)University of Michigan, Department of Biomedical Engineering, Ann Arbor, MI, USA

  • 1:45:00 PM 294. SIG-005: Demonstrating Comparability between Fresh and Cryopreserved Drug Substance, Lauren Jansen, PhD(1), Janet Huang, M.S.(1), Marissa Donovan, PhD(1), Michele McAuliffe(1), Mark Lalli, PhD(1), Drew Tietz, PhD(1), Lauren Wolf, PhD(1), Martha Rook, PhD(1), Susan Drapeau, PhD(1), Kayla Klein, Chris Sparages*, Roger Harrington; (1)Sigilon Therapeutics, Inc.,Cambridge, MA, USA

  • 2:00:00 PM 295. Potency Tests, Potency and Clinical Efficacy, Carl Simon, PhD*, National Institute of Standards & Technology, Gaithersburg, MD, USA

  • 2:15:00 PM 296. Quantitative, traceable determination of cell viability using absorbance microscopy, Greta Babakhanova(1), Stephen Zimmerman(1), Laura Pierce(1), Sumona Sarkar(1), Nicholas Schaub(2), Carl Simon, Jr., PhD(1)*; (1)National Institute of Standards & Technology, Gaithersburg, MD, USA, (2)National Institutes of Health, Bethesda, MD, USA

  • 2:30:00 PM 297. In vitro Characterization of Biodegradable Photopolymerizable Polymers for Biomedical Applications, Hafiz Busari, MS*, Mathew Stanford, MS, Debra Tindall, PhD, Michael Vaughn, PhD, Poly-Med, Inc., Greenville, SC, USA

  • 2:45:00 PM 298. Assessment of Factors Impacting Material-mediated Hemolysis Results in the ASTM F756-17 Testing Standard, Cindy Liu, Qijin Lu*, Shelby Skoog, Nidhi Kalaria, Richard Malinauskas, US Food and Drug Administration

  • 3:00:00 PM 299. In-vitro test methods to screen materials for susceptibility to third body wear and quantification of metal ions and particulate debris for implanted metal devices, Arindam Paul(1), Lauren Ickes(1,2), Alexander Nguyen(1), Paul Turner(1), Diane Smith(1), Eric M. Sussman(1), Sherrill Lathrop Blitzer(1)*; (1)US Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, (2)The Department of Biomedical Engineering, University of Akron, OH, USA

  • 3:15:00 PM 300. Evaluation of Alternative Materials for Personal Respirators Using a Novel Low-Cost Evaluation Device, Quinton Burke, B.S.*, Kevin Aroom, M.S., P.E., Martha Wang, Ph.D., Robert E. Fishchell Institute for Biomedical Devices, University of Maryland, College Park, MD, USA

Immune Cell Interfaces: Immunotherapies, Implants, and Immunobiology

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Laurel C-D, 4th Floor


Interfaces with and among immune cells are critical to homeostasis and can lead to the success or failure of new therapies and medical devices. This session aims to shed light on our emerging understanding of immune cell-cell and cell-biomaterial interfacial phenomena and methods to engineer these interactions in order to better diagnose and treat human diseases. Application areas include (but are not limited to): therapeutics (natural and synthetic), diagnostic devices, screening approaches, implants, cell/tissue matrices, bioreactors, modeling, etc.


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 PM 301. Organoid Polymer Functionality and Mode of Bacterial Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epi- genetics and Early Memory B Cell-Like Response, Pamela Graney(1), Zhe Zhong(2), Sarah Post(1), Ilana Brito(1), Ankur Singh(2)*; (1)Cornell University, Ithaca, NY, USA, (2)Georgia Institute of Technology, Atlanta, GA, USA

  • 1:45:00 PM 302. Multivalent, T Cell-Engaging Cytokines for Leukemia Immunotherapy, Erik Dreaden, PhD*, Emory School of Medicine, Georgia Institute of Technology, Children’s Healthcare of Atlanta, Atlanta, GA, USA

  • 2:00:00 PM 303. Immunometabolic Approaches to Mitigating Formation of the Foreign Body Response Capsule, Sabrina Macias*, Olivia Palmer, Arun Wanchoo, PhD, Gregory Hudalla, PhD, Benjamin Keselowsky, PhD, University of Florida, Gainesville, FL, USA

  • 2:15:00 PM 304. Discovery of Vomocytosis by Cryptococcus neoformans in Dendritic Cells, Jamal Lewis*, PhD, Noah Pacifici, Agustina Diener, Melissa Cruz-Acuña, PhD, Neeraj Senthil, Hyunsoo Han, University of California, Davis, CA, USA

  • 2:45:00 PM 305. Host type-2 immune response to xenogeneic serum proteins impairs biomaterial-directed cell therapy, Andrés García, PhD, Rebecca Schneider, Pranav Kalelkar, PhD, Hannah Theriault, María Coronel, PhD, Karen Martin*, Georgia Institute of Technology, Atlanta, GA, USA

  • 3:00:00 PM 306. Macrophage Activation in Response to Shape-memory Polymer Coated Embolization Coil Devices, Sarah Chau, Scott Herting, Dillon Noltensmeyer, Hamzah Ahmed, Duncan Maitland, Shreya Raghavan*, Texas A&M University, College Station, TX, USA

  • 3:15:00 PM 307. Activation of Canonical Wnt Signaling Primes Pro-inflammatory Macrophage Polarization in Response to Titanium Physicochemical Cues, Derek Avery*, Loc Bui, Jefferson Abaricia, Arth Shah, Lais Morandini, PhD, Rene Olivares-Navarrete, PhD, Virginia Commonwealth University, Richmond, VA, USA

Panel Discussion: Biomaterials Battle: Are In Vitro Models Worth It?

Panel Discussion: Global Trends for Reprocessing, Reuse, and Infection Control

Smart Biomaterials for Drug Delivery

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Kent A-C, 4th Floor


Smart biomaterials (i.e., targeted and/or stimuli-responsive) have great potential for efficient delivery of therapeutics, increasing therapeutic activity, while avoiding biological barriers and decreasing toxicity and other adverse effects like drug resistance. Both endogenous and exogeneous stimuli have been utilized to trigger stimuli-responsive materials including pH, temperature, ionic strength, chemical and/or mechanical microenvironment, redox potential, and light. Similarly, many targeting mechanisms ranging from passive (e.g., enhanced permeation and retention) to active targeting approaches (e.g., antibody, nucleic acid, peptide ligand functionalization) have been integrated into targeted drug delivery systems. This session will focus on the development and use of such materials for applications including, but not limited to, cancer, and infectious, orthopedic, ophthalmic, and autoimmune diseases.


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 PM 308. INVITED SPEAKER: Engineering Immunity Using Biomaterials, Natalie Artzi, PhD, Harvard University

  • 2:00:00 PM 309. Light-Activatable Ethanol Injection for the Treatment of Locally Unresectable Tumors, Chen-Hua Ma*, Jeffrey Yang, Huang- Chiao Huang, Jenna Mueller, University of Maryland, College Park, MD, USA

  • 2:15:00 PM 310. Tumor Responsive and Tunable Polymeric Platform to Treat Glioblastoma, Elizabeth Gurysh, PhD*, Kathryn Moore, PhD, Allison Schorzman, PhD, Taek Lee, William Zamboni, PhD, Eric Bachelder, PhD, Shawn Hingtgen, PhD, Kristy Ainslie, PhD, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

  • 2:30:00 PM 311. Noninvasive Refilling of Biomaterial Drug-Eluting Depots, Yevgeny Brudno*, PhD, Christopher Moody, Sharda Pandit, Sandeep Palvai, PhD, Joint Department of Biomedical Engineering at UNC - Chapel Hill and NC State - Raleigh, Raleigh, NC, USA

  • 2:45:00 PM 312. Development of Antibody/siRNA Nanocarriers to Target Wnt Signaling in Triple-Negative Breast Cancer, Megan Dang(1)*, Sejal Suri(1), Carolina Gomez Casas(1), Rachel Riley, PhD(2), Emily Day, PhD(1); (1)University of Delaware, Newark, DE, USA, (2)Rowan University, Glassboro, NJ, USA

  • 3:00:00 PM 313. Host-Guest Supramolecular Recognition in Hydrogel Drug Delivery, Matthew Webber, PhD*, University of Notre Dame, Notre Dame, IN, USA

  • 3:15:00 PM 314. Protease-responsive drug delivery in a chemically-induced mouse model of subcutaneous inflammation, Dang Nguyen, PhD*, Thi Hong Anh Truong, PhD, Tram Dang, PhD, Nanyang Technological University, Singapore, Singapore

Tissue Engineering (SIG) 1

Timeslot: Friday, April 29, 2022 - 1:30pm to 3:30pm
Room: Dover A-C, 3rd Floor


The field of tissue engineering has made significant progress in the last two decades through the development of novel biomaterials and three-dimensional scaffold fabrication methods. Efforts to engineer cell niches to control cell behavior over multiple length scales and precisely guide tissue regeneration have advanced the field. To achieve this, a diverse range of novel technologies have been leveraged, including 3D bioprinting, electrospinning, microfluidics, light-based patterning, and directed assembly, to enable notable progress in controlled release and spatial presentation of biomolecules, organ integration, production of tissue models, single cell-level presentation of microenvironmental cues, and molecular-level control of biomaterial composition. This session will highlight recent trends in novel biomaterials and scaffold development and advanced biofabrication techniques towards the development of sophisticated tool kits for tissue engineers


Abstracts will be available for download on April 27, 2022.

  • 1:30:00 PM 315. Control of Redox Diffusion-Mediated Crosslinking for Conform- able Hydrogel Coatings, Abbey Nkansah*, Megan Wancura, Andrew Robinson, Elizabeth Cosgriff-Hernandez, PhD, University of Texas at Austin, Austin, TX, USA

  • 1:45:00 PM 316. Serologic Cross-Reactivity of SARS-CoV-2 with Bat Coronavirus in Cambodia, Andrea Lucia Alfonso, B.S.(1)*, Parinaz Fathi, PhD(1), Zoe Putman(2), Mattew Drew(2), Dominic Esposito, PhD(2), Luiz Fabiano Oliveira, PhD, MD(3), Jessica Manning, MD(3), Kaitlyn Sadtler, PhD(1); (1)National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, USA, (2)Frederick National Laboratory for Cancer Research, Frederick, MD, USA, (3)National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Phnom Penh, Cambodia

  • 2:00:00 PM 317. Hyaluronan Based Nanofibrils With Co-Axial Electrospinning For Spontaneous Assembly Of Cell And Matrix, Oanh-Vu Pham-Nguyen*, Wei Mao, Jaekeun Park, Miso Lee, Wanho Cho, Hoai-Thuong Bui, Hyuk Sang Yoo, Kangwon National University, Chuncheon, Republic of Korea

  • 2:15:00 PM 318. Fabrication of Filamentous Cell Penetrating Peptides Toward Targeted Molecular Imaging and Therapy, He Dong*, Su Yang, The University of Texas at Arlington, Arlington, TX, USA

  • 2:30:00 PM 319. Effect of Fatty Acid Chain Length and Reaction Time on the Acylated Electrospun Chitosan Membrane Characteristics, Rabeta Yeasmin*, Jessica Amber Jennings, PhD

  • 2:45:00 PM 320. Manipulation of Hydrogel Charge Interactions for the Enhancement of Extrusion Bioprinting Resolution, Shannon McLoughlin, B.S.(1,2)*, John Fisher, PhD(1,2); (1)University of Maryland, College Park, MD, USA, (2)Center for Engineering Complex Tissues, College Park, MD, USA

  • 3:00:00 PM 321. Tumor-driven Extracellular Matrix Remodeling Influences Therapeutic Response in a Glioblastoma Model, Sara Pedron*, Edward Neves, Brendan Harley, University of Illinois at Urbana-Champaign, Urbana, IL, USA

  • 3:15:00 PM 322. Stabilizing a microfluidic oral mucosa tissue model with photo-crosslinking for long-term culture, Khanh Ly, MS*, Xiaolong Luo, PhD, Christopher Raub, PhD, Catholic University of America, Washington, DC, USA