Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Silver Pearl 1
About
This session will look at aspects of these advancing techniques in relation to clinical need, indications, challenges, regulation, and multidisciplinary approach to help better understanding of the technology and process of translation and expedite moving the technology to industrial production and clinical translation.
2B: Bioactive Materials for Soft Tissue Regeneration
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Silver Pearl 2
About
Advances in hard and soft tissue grafting in the craniofacial region have gone past autogenous grafts from the mandible, palate and iliac crest to allografts, allowlists and xenografts. Some of these materials have bioactive properties, others are mixed with growth enhancers and/or growth factors to optimize hard and/or soft tissue regeneration.
2:45 PM. 53. A Mechanically Tunable Granular Nanofiber-Hydrogel Composite for Host Macrophage Conditioning and Soft Tissue Remodeling. Jiayuan Kong, Zhi-Cheng Yao, Jessica Stelzel, Dr. Joshua Doloff, Dr. Sashank Reddy, Dr. Hai-Quan Kong, Jeffrey Chen. Institute for NanoBioTechnology, Johns Hopkins University.
3:00 PM 54. Catalase-immobilized Syringes to Create Hyperoxia-inducible Hydrogels for In Situ Tissue Regeneration. Jeon II Kang, Prof. Kyung Min Park, PhD, Incheon National University, Research Center for Bio Materials & Process Development.
3:15 PM. 55. Zinc Ion-releasing Hydrogels for In Situ Tissue Regeneration. Yeonjeong Kim, MS; Prof. Kyung Min Park, PhD; Incheon National University, Research Center for Bio Materials & Process Development.
3:30 PM. 56. A Dynamic Cell-Based Therapy Patch for Accelerating Wound Healing. Christian Schreib, Lizzy Kelley, Scott Johnson, Peng Jiang, Raghav Garg, Tzahi Cohen-Karni, Stephan Badylak, Omid Veiseh. Rice University, University of Pittsburgh, Cleveland State University.
3:45 PM 57. Decellularized Dehydrated Human Amniotic Membranes Support the Cellular Functions of Human Tenocytes In Vitro. Anna Gosiewska,PhD; Yong Mao, PhD; Nicole Protzman, MS; Nikita John, BS; Adam Kuehn, MD; Desiree Long, MBA; Raja Sivalenka, PhD; Robert Hariri, MD, PhD; Stephen Brigido, DPM. Celularity Inc., Rutgers University, Healthcare Analytics, LLC.
4:00 PM. 58. Nanofiber Aerogels with Precision Channels and LL-37-derived Peptides for Diabetic Wound Healing. Jingwei Xie, University of Nebraska Medical Center.
2C: Dental/Craniofacial Biomaterials (SIG)
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Silver Pearl 3
About
The Dental/Craniofacial Biomaterials Special Interest Group focuses on basic, applied, and clinical biomaterials research using approaches ranging from synthetic materials to biological mechanisms of therapy, and including materials/biological constructs and tissue structure-function analyses as biomimetic/design bases. Each of these approaches converge into the larger objective of restoring oral tissue structure and function. Issues related to materials used or having potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region are included. New dental biomaterials technologies include advanced inorganic and organic materials, biomimetics, smart materials, tissue engineering, drug delivery strategies and surface modified materials.
2:45 PM. 59. Monodisperse Microspheres Distinctly Release Multifunctional Peptide-Conjugated Gene Carrier/miRNA218 Complexes for Bone Defect Regeneration. Qian Li, PhD; Xiaohua Liu, PhD. Texas A&M University School of Dentistry.
3:00 PM. 60. A new approach to evaluate the bond strength of dental restorations. Santiago Orrego, PhD; Carolina Montoya, PhD; Mansi Bharatkumar, DDS. Temple University.
3:15 PM 61. Immunomodulatory Antagonist Nanocoatings for Implant Soft Tissue Healing. Nicholas Fischer, PhD; John Pizarek, DDS; Prof. Conrado Aparicio, PhD; University of Minnnesota, United States Navy Dental Corps, Universitat Internacional de Catalunya,Institute for Bioengineering of Catalonia.
3:30 PM. 62. Thermoresponsive Polymeric Simvastatin Prodrug Hydrogel for the Treatment of Experimental Periodontitis in Rats. Xiaoke Xu, Dr. Zhenshan Jia, Dr. Ningrong Chen, Dr. Subodh Lele, Dr. Richard Reinhardt, Dr. Amy Killeen. University of Nebraska Medical Center.
3:45 PM 63. Surface treatment of titanium oxides using polyaniline for photocatalytic, antibacterial and biocompatible implants. Aya Ali, BDS, MSc; Sheetal Chowdhury, Mary Carr, Amol Janorkar, Mary Marquart, Jason Griggs, Joel Bumgardner, Michael Roach. University of Mississippi Medical Center, University of Memphis.
4:00 PM 64. 3D Woven Magnesium Alloy Scaffolds for Craniofacial Defects. Beril Ulugun, Dr. Ju Xue, Dr. Ryan Guilbault, Greg Osgood, Warren Grayson, Prof. Timothy Weihs, Srujan Singh, Dr. Yuxiao Zhou. Johns Hopkins University, The Johns Hopkins University School of Medicine, Texas A&M University.
2D: Bioinspired Approaches to Supramolecular Biomaterials
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Coral 1-2
About
Progress in cell and protein biology are fueling innovation of increasingly sophisticated and functional self-assembling, supramolecular biomaterials. Molecular-level control over their self-assembly dynamics and overall material/biological properties offers novel opportunities for cellular engineering, drug delivery, and tissue regeneration. This session will stimulate progress on cutting-edge bioinspired approaches to engineer the functionality, self-assembly dynamics, and stimuli-responsiveness of supramolecular biomaterials. We encourage contributions spanning the entire range of the research landscape, from progress on mining biological systems to extract new biomaterial design principles to new developments in the characterization and application of the resulting bioinspired supramolecular biomaterials.
2:45 PM. 65. Synthetic High-Density Lipoprotein-Like Nanoparticles as a Targeted Approach to Modulate Inflammation in Cytokine-Stimulated Keratinocytes. Jacquelyn Trujillo, BS; Andrea Calvert, PhD; Jonathan Rink, PhD; Han Peng, PhD; Kurt Lu, PhD; Robert Lavker, PhD; Colby Thaxton, MD, PhD; Feinberg School of Medicine Northwestern University.
3:00 PM 66. Phase Separation Driven Assembly of Highly Stable Protein Nanoparticles. Alexa Regina Avecilla, Felipe Garcia Quiroz, PhD; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University.
3:15 PM 67. Controlling self-assembly and bioactivity of de novo peptides via block heterochirality. Conor O'Neill, Jonathan Fascetti, Zain Clapacs, Paresh Shrimali, PhD; Amanda Winkler, Mark White, PhD; Jai Rudra, PhD. Washington University in St. Louis, University of Texas Medical Branch.
3:30 PM 68. Rational Design of Supramolecular Polymer-Prodrugs for Regenerative Medicine. Kelsey DeFrates, Joakim Engstrom, PhD; Nivedina Sarma, Athiyya Umar, Jisoo Shin, PhD; Jing Cheng, PhD; Weiran Xie, Darrin Pochan, PhD; Ahmad Omar, PhD; Phil Messersmith, PhD. University of California, Berkeley, University of Delaware.
3:45 PM 69. Designing Peptidic Assemblies as Bioelectronic Interfaces and Adaptive Bioscaffolds. Herdeline Ardona, PhD; Zefan Yao, PhD; Yuyao Kuang, University of California, Irvine.
4:00 PM. 70. Tunable and Responsive Modulation of Host–Guest Recognition in Supramolecular Hydrogels. Prof. Matthew Webber, PhD; Lei Zou, PhD; Adam Braegelman, PhD; Bo Su, Christopher Addonizio, University of Notre Dame.
2E: Sex, Ancestral & Geographical Determinants in Biomaterials Research
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Coral 3-4
About
The unprecedented nature of the COVID-19 pandemic has reintroduced/continued the conversation about the health inequities that disproportionately affect individuals based on social determinants of health like gender, race, and socioeconomic background. From an engineering and scientific perspective, biological sex and genetic ancestral differences can be used to shed light on differences between patient populations, as these variables have been shown to result in differences in both disease prevalence and manifestation. Yet, our mechanistic knowledge of the underlying molecular and cellular mechanisms involved, and how these differences lead to performance differences for biomaterials, remain poorly characterized. This session will showcase the current status and future of purposefully designed biomaterials to address both health and healthcare disparities and study their underlying causes. This session will encompass a diverse portfolio of topics including (but not limited to) the design of sex- and ancestry- specific cellular microenvironments, the development of sex-specific drug delivery approaches, and the fabrication of biomaterials to address challenges in global health.
2:45 PM 71. Metanalysis of Global Participation in Biomaterials Publications. Ana Porras, University of Florida.
3:00 PM. 72. Leveraging Machine Learning to Assess How Ancestry is Reported in Biomaterial Models. Nisha Kotta, Alison Veintimilla, Tomer Zilbershtein, Ylan Beaudoin de Roca, Dr. Erika Moore. University of Florida, Thomas Jefferson University.
3:15 PM 73. Omniphobic Spray Coating Created from Hierarchical Structures with Repel and Kill Mechanism Prevents the Pathogenic Contamination of High-touch Surfaces. Noor Abu Jarad, Kenneth Rachwalski, Fereshteh Bayat, Shadman Khan, Amid Shakeri, Roderick MacLachlan, Martin Villegas, Prof. Tohid Didar. McMaster, McMaster University.
3:30 PM 74. Circulating Sex Hormone Response to Traumatic Brain Injury: Implications for Drug Delivery. Amberlyn Simmons, Veronica Pena, Heather Bimonte-Nelson, Dr. Chris Plaisier, Dr. Sarah Stabenfeldt, Dr. Rachael Sirianni. Arizona State University, University of Massachusetts Amherst.
3:45 PM 75. Sex-specific Valvular Myofibroblast Activation in Response to Nano-scale Stiffness Cues. Rayyan Gorashi, MS; Michaela Wenning, BS; Joseph Grim, PhD; Cierra Walker, PhD; Brisa Pena, PhD; Luisa Mestoni, PhD; Kristi Anseth, PhD; Brian Aguado, PhD; University of California, San Diego, University of Colorado, Boulder, University of Colorado, Anschutz Medical Campus, Sanford Consortium for Regenerative Medicine.
4:00 PM 76. A Cell-Degradable, Photo-Stiffening Hydrogel to Study Sex-Differences in Pulmonary Fibrosis. Mikala Mueller, MS; Chelsea Magin, PhD. University of Colorado Denver , Anschutz Medical Campus
2F: Extracellular Vesicles for Biomedical Applications
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Coral 5
About
Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session entitled " Extracellular Vesicles for Biomedical Applications" is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, tissue engineering, and drug delivery. This session will target scientists from a wide background (graduate students, postdoctoral fellows, academic professors, industry members, clinicians) who are developing EVs towards biomedical applications.
2:45 PM 77. Stem Cell-Derived Exosome Nebulization Therapy (SCENT) Promotes Heart Repair in Mice and Pigs. Junlang Li, Dr. Ke Cheng. University of North Carolina at Chapel Hill & North Carolina State University.
3:00 PM 78.Engineered Extracellular Vesicles Attenuate Inflammation in a Murine Model of Acute Lung Injury. Ana Salazar Puerta, Maria Rincon Benavides, Tatiana Cuellar-Gaviria, Lilibeth Ortega-Pineda, Devleena Das, Daniel Dodd, Daniel Gallego-Perez, Natalia Higuita-Castro. The Ohio State University.
3:15 PM 79. Phosphatidylserine-incorporated Exosome Mimetics Encapsulating CXCR3 Antagonist Inhibit Osteoclast Differentiation and Alleviate Osteoporosis. Minjee Kang, PhD; Jiabing Fan, M.D..PhD; Michelle Chiang, Tara Aghaloo, DDS, PhD; Min Lee, PhD. University of California, Los Angeles, University of Maryland Eastern Shore.
3:30 PM 80. Engineered Extracellular Vesicles Loaded with Pro-Vascular Cargo Induced Direct Reprograming to Endothelial Cells and Promote Wound Closure In Vivo. Maria Rincon-Benavides, Dr. Tatiana Cuellar-Gaviria, Natalia Mendonca, Ana Salazar-Puerta, Dr. Britani Blackstone, Dr. Heather Powell, Dr. Daniel Gallego-Perez, Dr. Natalia Higuita-Castro. The Ohio State University.
3:45 PM 81. Immune Engineered Extracellular Vesicles to Modulate T Cell Activation in Type 1 Diabetes. Matthew Becker, PhD; Leeana Peters, Thinzar Myint, PhD; Todd Brusko, PhD; Edward Phelps, PhD. University of Florida.
4:00 PM 82. Analysis and Biomimetic in vitro Modeling of Extracellular Vesicle-Mediated Perineural Invasion. Emory Gregory, Isabel Powers, Azemat Jamshidi-Parsian, MS; Robert Griffin, PhD; Young Hye Song, PhD; University of Arkansas, University of Arkansas for Medical Sciences.
2G: Devices Designed for Imaging
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Seaglass
About
Imaging materials within the context of anatomy or for in vitro evaluation is often limited to small slices and destructive techniques. Research into highly imageable materials for tissue engineering, drug delivery and devices allows for less invasive monitoring of such systems. This symposium will highlight cutting edge material design for enhanced imaging with systems such as optical coherence tomography, ultrasound, fluorescence, magnetic resonance imaging, computed tomography and others and provide perspectives on need for new materials for alternative modalities. Abstracts will be accepted in all areas of imageable materials however, responsive or multi-modal materials are of special interest.
2:45 PM 83. INVITED SPEAKER
3:15 PM. 84. TAT2: Next-generation Endoscopic Tattoo Inks for Multimodal Imaging. Jordan Yaron, PhD; Mallikarjun Gosangi, PhD; Subhadeep Dutta, PhD; Mukti Vats, PhD; Rahul Pannala, MD; Kaushal Rege, PhD. Arizona State University, Mayo Clinic.
3:30 PM. 85. Nondestructive, Quantitative Monitoring of Tissue Scaffolds with Spectral Photon-Counting Computed Tomography. Connor Evans, Lan Li, Carmen Gil, Dr. Vahid Serpooshan, Ryan Roeder, PhD; University of Notre Dame, Emory University, Georgia Institute of Technology.
3:45 PM. 86. Gadolinium-doped hafnium oxide nanoparticles for contrast-enhanced imaging of photopolymerized hydrogels. Lan Li, Dr. Tracie McGinnity, James Bathon, Dr. Irfan Khan, Prof. Anthony Hoffman, Prof. Ryan Roeder. University of Notre Dame.
4:00 PM 87. Incorporating Hydroxyapatite Nanoparticles to Improve the Echogenic Properties of Polyurethane Composites. Samuel Vibostok, Dante Leone, Mackenzie Baro, Christopher Bashur, PhD; Abby Whittington, PhD. Virginia Polytechnic Institute & State University, Florida Institute of Technology.
Invited Speaker(s)
2H: Applied Biomaterials for Microphysiological Systems
Timeslot: Wednesday, April 19, 2023 - 2:45pm to 4:15pm
Room: Shorebreak
About
Microphysiological systems (MPSs) are systems, often microfluidic in nature, of interconnected 2D or 3D cellular constructs designed to recapitulate the multi-tissue structure and function of one or more organ systems. MPSs, also commonly referred to as organs-on-a-chip or in vitro organ constructs (including organoids), have the potential to revolutionize the translational pathway for novel biomaterials, pharmaceuticals, and biopharmaceuticals by minimizing or even negating the need for small animal testing. Topics include, but are not limited to, cutting-edge biomaterials-based strategies to recapitulate native and pathological (i.e., disease model) tissue structures and functions in MPSs and translational applications of biomaterials-based MPSs.
2:45 PM 88. 3D Muscle Satellite Cell Niche System for Identifying Anti-geronic Factors in Parabiosis. Dr. Yunki Lee, Dr. Jeongmoon Choi, Young C. Jang. Emory University, Georgia Institute of Technology.
3:00 PM 89. A multifunctional epicardial bioelectronic patch made from soft rubbery materials. Cunjiang Yu. Pennsylvania State University.
3:15 PM 90. Development of Tissue-Specific, Perfusable Vasculature in Microphysiological Systems. Kevin Ling, MS; Arvind Srivatsava, MS; Annika Deans; Robert Brown; Kannan Manian, PhD; Steven George, PhD; James McGrath, PhD; Ruchira Singh, PhD; Danielle Benoit, PhD; University of Rochester, University of California Davis, University of Oregon.
3:30 PM 91. Hydrogen peroxide-releasing hydrogels for cellular behavior manipulation and therapeutic applications. Thi Thai Thanh Hoang, PhD; Yunki Lee, PhD; Young Jang, PhD; Emory University School of Medicine.
3:45 PM 92. A Novel Block Copolyester Photoresin for UV-assisted 3D Printing. Warrick Ma, Yadong Wang. Meinig School of Biomedical Engineering, College of Engineering, Cornell University.
4:00 PM 93. Hydrogel Encapsulation of Bacterial Biosensors for Detection of Inflammatory Metabolites in IBD. Samira Aghlara-Fotovat, Elena Musteata, Michael Doerfert, Moshe Baruch, PhD; Maya Levitan, Dr. Jeffrey Tabor, Dr. Omid Veiseh. Rice University.