5A: The US-Korea Joint Workshop on Biomaterials in Translational Medicine

5B: Biomaterials for Regenerative Engineerings 1

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Silver Pearl 2


Regenerative engineering aims to develop functional, bioactive, and instructive biomaterials and approaches for the regeneration of tissues through the convergence of engineering, medicine, developmental biology, and stem cell science. This symposium will highlight recent trends in developing functional biomaterials that play an active role in controlling cellular behaviors and tissue regeneration. We will include different classes of biomaterials such as proteins, polysaccharides, synthetic polymers, fibers, metals, ceramics, and hydrogels for applications in regenerative engineering. This session will also highlight the biomaterials that can direct cell fate and promote differentiation. Moreover, oral and poster presentations will cover the biomaterials that can facilitate drug delivery and immunomodulation. Translational strategies for taking these biomaterials from ‘Bench to Bedside’ will also be discussed during the symposium. We expect our interdisciplinary session, including material science, chemistry, biology, engineering, and medicine, will be of great significance to clinicians, industry members and academia.

  • 3:45 PM 209. Unconventional Biomaterials for Regenerative Medicine. Gulden Camci-Unal, PhD, University of Massachusetts Lowell, Lowell, MA, USA.

  • 4:00 PM 210. The Role of Injectable Biomaterials in Treating Laryngeal Nerve Injury. Alisa Isaac, Teja Guda, The University of Texas at San Antonio, San Antonio, TX, USA.

  • 4:15 PM 211. A Novel Injectable Piezoelectric Hydrogel for Osteoarthritis Treatment. Tra Vinikoor, Thanh Nguyen, PhD, University of Connecticut, Storrs, CT, USA.

  • 4:30 PM 212. Human Fibroblast-Derived Matrix Hydrogel Enables Regenerative Wound Remodeling via Interaction with Macrophages. Kwideok Park, PhD, Cininta Savitri, PhD, Sang Su Ha, PhD, Jae Won Kwon, Sung Hoon Kim, Young-Min Kim, PhD, Hyun-Mee Park, PhD, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea, KIST School, University of Science and Technology (UST), Seoul, Republic of Korea.

  • 4:45 PM 213. Biodegradable Piezoelectric Skin-Wound Scaffold. Ritopa Das, Thanh Nguyen, University of Connecticut, Storrs, CT, USA.

  • 5:00 PM 214. Conductive Elastomer for Bladder Regeneration. Rebecca Keate, Jonathan Rivnay, PhD, Guillermo Ameer, D.Sc.,Northwestern University, Evanston, IL, USA.

  • 5:15 PM 215. Decellularized Meniscus Scaffolds for Pediatric Laryngotracheal Reconstruction in a Porcine Model. Alexandra Dumas, Paul Gehret, Soheila Ali Akbari Ghavimi, PhD, Ian Jacobs, Riccardo Gottardi, University of Pennsylvania, Philadelphia, PA, USA, Childrens Hospital of Philadelphia, Philadelphia, PA, USA.

  • 5:30 PM 216. Rapid Magnetically Directed Assembly of Patterned Capillary-Scale Microvessels. Maggie Jewett, Harrison Hiraki, Michal Wojasiński, PhD, Amanda Bluem, Eashan Prabhu, Zenghao Zhang, William Wang, PhD, Abdon Pena-Francesch, PhD, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA, Warsaw University of Technology, Warszawa, Poland.

5C: Immune Engineering (SIG) 1

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Silver Pearl 3


Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy (immune-modulation), cell and gene therapy, immune microenvironment engineering, and systems immunology. These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.

  • 3:45 PM 217. Transient Injectable Stimulatory Hydrogels to Improve the Efficacy of CAR-T Therapies of Solid Tumors. Eric Appel, PhD, Stanford University, Stanford, CA, USA.

  • 4:00 PM 218. Lipid Nanoparticle Composition Shapes Immune Response to mRNA Vaccine and Potency of Anticancer Immunity. Yining Zhu, Jingyao Ma, Ruochen Shen, Ivan Vuong, Hai-Quan Mao, Johns Hopkins University, Baltimore, MD, USA.

  • 4:15 PM 219. Non-Inflammatory mRNA Vaccine for Antigen-Specific Immunomodulation in the Lung. Atanu Chakraborty, PhD, Shruti Dharmaraj, MS, Nhu Truong, Ryan Pearson, PhD, University of Maryland, Baltimore, Baltimore, MD, USA.

  • 4:30 PM 220. Biomaterial-based Ex vivo Natural Killer Cell Surface Engineering for Enhanced Cancer Immunotherapy. Sungjun Kim, PhD Student, Kyobum Kim, PhD, Dongguk University, Seoul, Republic of Korea.

  • 4:45 PM 221. PEGylation of Indoleamine 2,3-Dioxygenase for Systemic Immune Regulation. "Jennifer Simonovich, Alexander Kwiatkowski, Arun Wanchoo, Dorina Avram, Benjamin Keselowsky, University of Florida, Gainesville, FL, USA, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

  • 5:00 PM 222. Human Stem Cell Derived Beta-Like Cells Engineered to Present PD-L1 Improve Transplant Survival in NOD Mice Carrying Human HLA Class I. Jorge Santini-Gonzalez, Roberto Castro-Gutierrez, Matthew Becker, Chad Rancourt, Holger Russ, PhD, Edward Phelps, PhD, University of Florida, Gainesville, FL, USA, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

  • 5:15 PM 223. Vaccines Restore Homeostasis in Collagen Induced Arthritis Mice. Abhirami Thumsi, Srivatsan Swaminathan, Abhirami Suresh, Arezoo Esrafili, Madhan Jaggarapu, Kelly Lintecum, Michelle Halim, Tyler Johnston, Yasmin Sleiman, Shivani Mantri, Abhinav Acharya, Arizona State University, Tempe, AZ, USA.

  • 5:30 PM 224. Tissue-Engineered Stromal Reticula to Study Tolerogenic Fibroblastic Reticular Cell Properties in Type 1 Diabetes. Leonor Teles, Zachary Wilkes, Remi Creusot, Alice Tomei, Diabetes Research Institute, Miami, FL, USA, University of Miami, Coral Gables, FL, USA, Columbia Center for Translational Immunology, New York, NY, USA, Naomi Berrie Diabetes Center, New York, NY, USA.

5D: Stimuli-Responsive Biomaterials

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Coral 1-2


Materials that respond to environmental stimuli, such as heat, light, pH, or biological signals, provide unique tools for environmentally-responsive and/or temporal changes in biomaterial properties over time. These materials have broad potential applications in drug delivery, cell-responsive materials, tissue engineering, and medical device implantation. This session will highlight recent advances in designing and characterizing stimulus-responsive biomaterials.

  • 3:45:00 PM 225. Dithiolane-Based Dynamic Hydrogels for Photoinduced Crosslinking, Exchange, and Depolymerization. Benjamin Nelson, Bruce Kirkpatrick, Connor Miksch, Matthew Davidson, PhD, Nathaniel Skillin, Grace Hach, Benjamin Fairbanks, PhD, Jason Burdick, PhD, Christopher Bowman, PhD, Kristi Anseth, PhD, University of Colorado Boulder, Boulder, CO, USA.

  • 4:00 PM 226. Developing Enzyme-Sensitive Peptide-Polymer Conjugates for Cell-Mediated Degradation. Natasha Hunt, Srujan Singh, M.Tech, E. Thomas Pashuck, PhD, Warren Grayson, PhD, Lesley Chow, PhD, Lehigh University, Bethlehem, PA, USA, Johns Hopkins University, Baltimore, MD, USA.

  • 4:15 PM 227. Bioactive Protein Photorelease from Hydrogels via Tissue-penetrating Green Light. Teresa Rapp, PhD, Cole DeForest, PhD, University of Washington, Seattle, WA, USA.

  • 4:30 PM 228. Sorting and Harvesting Cells With Dynamic Bionterfaces. Sergiy Minko, PhD, Yongwook Kim, Ummay Jahan, Alexander Delchev, Nickolay Lavrik, Vladimir Reukov, University of Georgia, Athens, GA, USA, Oak Ridge National Lab, Oak Ridge, TN, USA.

  • 4:45 PM 229. Ultrasound-Responsive Biomaterial Platform for 3D Spheroid Gene Delivery to Model Early Tumor Initiation. Katherine Huynh, B.S., Mary Lowrey, B.S., Sara Evans-Dutson, B.S., Kevin Schilling, PhD, Danielle Brasino, PhD, Mithila Handu, PhD, Sean Speese, PhD, Carolyn Schutt Ibsen, PhD, Oregon Health and Science University, Portland, OR, USA.

  • 5:00 PM 230. A Protease-Based Theranostic as a Tool to Understand and Inhibit Calpain in Brain Injury. Marianne Madias, BS, Sophia Warlof, Ester Kwon, PhD, BS, University of California, San Diego, La Jolla, CA, USA.

  • 5:15 PM 231. Novel Intrinsically Disordered Protein Polymers with Tunable Band-Pass Phase Separation Behavior. Maria Giraldo Castano, Felipe Garcia Quiroz, Emory University, Atlanta, GA, USA, Georgia Institute of Technology, Atlanta, GA, USA.

  • 5:30 PM 232. Matrix Remodeling Modulates Therapeutic Potential of Heterotypic Cell Spheroids for Wound Healing. Victoria Thai, David Ramos-Rodriguez, PhD, Jonathan Leach, PhD, University of California Davis, Davis, CA, USA.

5E: Engineering Cells & Their Microenvironments (SIG) 1

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Coral 3-4


The Engineering Cells & Their Microenvironments Special Interest Group concentrates on technologies and approaches focused at the single cell level and encompassing engineering cell microenvironments, biomaterial-induced cell signaling, stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis.

  • 3:45 PM 233. Poly(Ethylene Glycol)-Based Microcarriers Alter Secretory Activity of Genetically-Modified Mesenchymal Stromal Cells. Gilad Doron, PhD, Levi Wood, PhD, Robert Guldberg, PhD, Johnna Temenoff, PhD, Georgia Institute of Technology & Emory University, Atlanta, GA, USA, University of Oregon, Eugene, OR, USA.

  • 4:00 PM 234. Strain-Stiffening Bottlebrush Polymer Hydrogels Influence hMSC Morphology and Mechano-transduction. Monica Ohnsorg, Varsha Rao, Alex Khang, Kristi Anseth, University of Colorado Boulder, Boulder, CO, USA.

  • 4:15 PM 235.Stem Cells in Sliding Hydrogels ‘Dance’ to Enhance 3D Chondrogenesis via Early Cytoskeletal and Nuclear Dynamics. Manish Ayushman, Georgios Mikos, Xinming Tong, Pamela Cai, Andrew Spakowitz, Sarah Heilshorn, Fan Yang, Stanford University, Stanford, CA, USA.

  • 4:30 PM 236. Stiff and Fast-Relaxing Hydrogel to Probe Pancreatic Ductal Adenocarcinoma Cell Behavior. Han Nguyen, Chien-Chi Lin, PhD, Purdue University, West Lafayette, IN, USA, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA.

  • 4:45 PM 237. Extracellular Matrix Stiffness Mediates Insulin Secretion in Pancreatic Islets via Phosphofructokinase Activity. Chelsea Garcia, BS, Keifer Holcomb, BS, Nikki Farnsworth, PhD, Colorado School of Mines, Golden, CO, USA.

  • 5:00 PM 238. Enzyme-Functionalized Covalent Alginate Microparticles for Low-Cost Anaerobic Culture. Tyrell Williams, Claudia Daboin, Paul Kim, Fengguang Guo, Paul de Figueiredo, PhD, Daniel Alge, PhD, Texas A&M University, College Station, TX, USA.

  • 5:15 PM 239. Preserving Vasculature on the Encapsulation Device Led to Successful Stem Cell Derived Beta Cell Engraftment. Gauree Chendke, Bhushan Kharbikar, PhD, Sudipta Ashe, PhD, Matthias Hebrok, PhD, Tejal Desai, PhD, University of California San Francisco, San Francisco, CA, USA, Technical University Munich (TUM), Garching-Forschungszentrum, Germany, Institute for Diabetes and Organoid Technology (IDOT) and Helmholtz Diabetes Center (HDC), Neuherberg, Germany, Brown University, Providence, RI, USA.

  • 5:30 PM 240. Non-Specific Proteolytic Degradation of Peptides Within Hydrogels Impacts Cell Function. Samuel Rozans, MS, Eugene Pashuk, PhD, Lehigh University, Bethlehem, PA, USA.

5F: Computational and Machine Learning Approaches

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Coral 5


Computational modeling and machine learning can enhance our ability to design and evaluate biomaterials for a variety of applications. This session will explore computational approaches and tools for designing biomaterials for tissue engineering and other applications, evaluating complex data from in vitro and in vivo studies, and predicting biomaterial performance in different microenvironments. Examples of these may include fluid mechanics and bio-transport models of drug/protein delivery, models of protein-protein and protein-material interactions, statistical modeling for biomaterial optimization, machine learning for biomaterial design and analysis, and bioinformatics-based platforms for analyzing complex data, including RNA sequencing and other -omics approaches.

  • 3:45 PM 241. Engineering High Throughput Screening Platforms for Cervical Cancer. Ines Cadena, Kaitlin Fogg, Oregon State University, Corvallis, OR, USA.

  • 4:00 PM 242. Rational Design of an Affinity-Based Biomaterial for Sustained Angiogenic Protein Delivery. Justin Svendsen, Simon Oh, Karly Fear, Parisa Hosseinzadeh, PhD, Marian Hettiaratchi, PhD, University of Oregon, Eugene, OR, USA.

  • 4:15 PM 243. Moderate-Affinity Affibodies for Affinity-Controlled Delivery of Bone Morphogenetic Protein-2 (BMP-2). Jonathan Dorogin, MS, Henry Hochstatter, Karly Fear, Parisa Hosseinzadeh, PhD, Marian Hettiaratchi, PhD, University of Oregon, Eugene, OR, US.

  • 4:30 PM 244. Computational Simulation of the Impact of Cell-Adhesive Sequence on Supramolecular Peptide Hydrogel Assembly. Andrew Thede, Clare Cocker, Liza Harold, Rachel Letteri, PhD, Kyle Lampe, PhD, University of Virginia, Charlottesville, VA, USA.

  • 4:45 PM 245. The Optimization of Poly(vinyl)-Alcohol-Alginate Beads with Tetrabutoxysilane for the Aerobic Cometabolism of Chlorinated Solvents. Conor Harris, MS, Hannah Gedde, Lewis Semprini, PhD, Willie Rochefort, PhD, Kaitlin Fogg, PhD, Oregon State University, Corvallis, OR, USA.

  • 5:00 PM Machine Learning Analysis of Matrix Architecture Following Treatment of Abdominal Adhesions,

    Jason L. Guo,1 Deshka S. Foster,1,2 Norah E. Liang,1 Charlotte E. Berry,1 D. Jack Li,1 Michael Januszyk,1, 2 Gerlinde Wernig,3 Jeffrey A. Norton,1 Michael T. Longaker.1, 2, 1Hagey Laboratory of Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA. 2Department of Surgery, Stanford University School of Medicine, Stanford, CA. 3Department of Pathology, Stanford University School of Medicine, Stanford, CA.

  • 5:15 PM 247. Predicting Ti-6Al-4V Corrosion Using Artificial Intelligence. Michael Kurtz, BS, Ruoyu Yang, PhD, Mohan Elapolu, PhD, Dinghe Liu, MS1,2, Rahul Rai, PhD, Jeremy Gilbert, PhD, Clemson University, Charleston, SC, USA, Medical University of South Carolina, Charleston, SC, USA.

  • 5:30 PM 248. 3D Mapping of Whole Human Fallopian Tubes at Single-Cell Resolution. Andre Forjaz, MS, Ashleigh Crawford, Pei-Hsun Wu, Ashley Kiemen, Ie-Ming Shih, Denis Wirtz,Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Baltimore, MD, USA, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

5G: Biomaterials for Women's Health

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Seaglass


The tissues of the female reproductive system demonstrate unique functional and mechanical properties, yet female reproductive health has historically been significantly understudied and underfunded. This session will highlight advances in biomaterials and tissue engineering approaches to consider complex, multi-cellular environment of many of these tissues to advance our understanding of reproductive health, disease and age-related changes. Topics include disorders in reproductive tissues (e.g. endometriosis, cancer, premature ovarian insufficiency, infertility, preterm birth), multicellular tissue-level interactions and mechanics in reproductive health, extracellular matrix dynamics and sex-related differences in chronic diseases.

  • 3:45 PM 249. Micromechanical Characterization with AFM Indentation and Viscoelastic Modeling Reveals both Elastic and Viscoelastic Heterogeneities in Ovarian Tissue. Samantha Stewart, Wenquan Ou, PhD, Xiaoming He, PhD, University of Maryland, College Park, College Park, MD, USA.

  • 4:00 PM 250. Multi-Compartment Organoids of the Human Fallopian Tube. Ashleigh Crawford, Isha Bhorkar, Andre Forjaz, Triya Roy, David Schell, Ashley Kiemen, PhD, Ie-Ming Shih, MD, PhD, Tian-Li Wang, PhD, Denis Wirtz, PhD, Johns Hopkins University, Baltimore, MD, USA, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

  • 4:15 PM 251. Designing a Synthetic Scaffold to Support Human. Folliculogenesis in Vivo. Monica Wall, M.S., Ariella Shikanov, PhD, University of Michigan, Ann Arbor, MI, USA.

  • 4:30 252. Developing a Microporous Annealed Particle Hydrogel for Human Ovarian Tissue Encapsulation. Despina Pavlidis, Ariella Shikanov, PhD,University of Michigan, Ann Arbor, MI, USA.

  • 4:45 PM 253. Developing Semi-synthetic Biomaterial Tools to Model the Interface of Endometriotic Lesions & Healthy Tissue. Hannah Theriault, Hannah Kimmel, Kathryn Clancy, PhD, Gregory Underhill, PhD, Brendan Harley, ScD, University of Illinois at Urbana-Champaign, Champaign, IL, USA.

  • 5:00 PM 254. Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for Selective mRNA Delivery to the Placenta. Hannah Safford, Kelsey Swingle, Hannah Geisler, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA.

  • 5:15 PM 255. Co-culture Organoids Recapitulate the Human Menstrual Cycle and Reveal Inflammatory Cascades in Endometriosis. Laura Bahlmann, PhD, Juan Gnecco, PhD, Alexander Brown, PhD, Lauren Baugh, PhD, Jeremy Huang, PhD, Kira Buttery, Clara Ives, Brittany Goods, Victor Hernandez-Gordillo, Doug Lauffenburger, PhD, Megan Loring, Keith Isaacson, MD, Linda Griffith, Bryan Bryson, PhD,
    Massachusetts Institute of Technology, Cambridge, MA, USA, Tufts University, Medford, MA, USA, Dartmouth College, Hanover, NH, USA, Newton Wellesley Hospital, Newton, MA, USA, Ragon Institute, Cambridge, MA, USA.

  • 5:30 PM 256. Hybrid Poly(ethylene glycol) and Hyaluronic Acid Bioactive Hydrogels for Endometrial Tissue Engineering. Samantha Holt, A. Nihan Kilinc, Christina Kim, Linda Griffith, Massachusetts Institute of Technology, Cambridge, MA, USA.

5H: BioInterfaces (SIG)

Timeslot: Thursday, April 20, 2023 - 3:45pm to 5:45pm
Room: Shorebreak


The junction between materials and biological systems is a critical and complex interface with the potential to control the function of macromolecules and dictate cell and tissue responses. Increasingly, cells and biomacromolecules are designable components of biomaterials, creating additional opportunities for innovative research at the interface of materials science and fundamental biology. This session serves as a forum for advances in approaches to modulate interfacial properties, investigations of structure-function and self-assembly at biointerfaces, and applications of interface-driven biomedicine. We also encourage contributions that advance a biomaterials lens to cutting-edge research in protein and cell biology, and research that translates progress in molecular and cell biology into innovative biomaterials.

  • 3:45 PM 257. INVITED SPEAKER.

  • 4:15 PM 259. Decoding Glycoengineered Vaccine and Carrier Immunogenicity Using Biomaterials-based Immune Organoids. "Tyler Moeller1, Shivem Shah1, Kristine Lai2, Natalia Lopez-Barbosa1, Primit Desai1, Weiyao Wang1, Zhe Zhong2, Matthew DeLisa1, Ankur Singh1,Cornell University, Ithaca, NY, USA, 2Georgia Institute of Technology, Atlanta, GA, USA.

  • 4:30 PM 260. Shaking Hands with Yourself: 3D Nanostructures to Inducing Cellular ‘Self-Adhesion’ to Adhere Cells to Biomaterials. Daniel Cohen, PhD, Anamika Singh, PhD, Lauren Rawson. Princeton University.

  • 4:45 PM 261. Controlling Biomaterial Associated Infections by Small Molecules that Interfere with Nucleotide Second Messenger Signaling. Chen Chen, Christopher Siedlecki, PhD, Harry Allcock, PhD, Lichong Xu, PhD, Alyssa Ochetto, The Pennsylvania State University, University Park, PA, USA, Penn State University College of Medicine, Hershey, PA, USA, Rowan University, Glassboro, NJ, USA.

  • 5:00 PM 262. Transcriptional Reprogramming of Endothelial Cells by Topographical Micropatterning via YAP. Meghan Fallon, Anthony Barnes, PhD, Monica Hinds, PhD,Oregon Health & Science University, Portland, OR, USA.

  • 5:15 PM 263. Directing 4D Cell Fate through Irreversible Protein Photoassembly in Biomaterials and in Living Cells. Emily Ruskowitz, PhD, Brizzia Munoz-Robles, Cole DeForest, PhD,University of Washington, Seattle, WA, USA.

  • 5:30 PM 264. Electroconductive Agarose Hydrogels Modulate MSC Adhesion and Spreading Through Protein Adsorption. Alena Casella, Alyssa Panitch, PhD, J. Kent Leach, PhD, University of California, Davis, Davis, CA, USA, UC Davis Medical Center, Sacramento, CA, USA, Georgia Institute of Technology, Atlanta, GA, USA, Emory University, Atlanta, GA, USA.