8B: Biomaterial-Based In Vitro Cancer/Tumor Models for Drug Screening and Diagnostics 2

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Silver Pearl 2

  • 10:15 AM 392. INVITED SPEAKER.

  • 10:45 AM 393. Therapeutic Nanocarriers Inhibit Chemotherapy-Induced Breast Cancer Metastasis. Tianyu Li, PhD, Tolulope Akinade, MD/PhD, Jie Zhou, PhD, Hongxia Wang, Qisong Tong, Siyu He, Emily Rinebold, Luis Valencia Salazar, Divya Bhansali, Yiling Zhong, Jing Ruan, Jinzhi Du, Piero Dalerba, Kam Leong, Professor, Columbia University, New york, NY, USA, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China, South China University of Technology, Guangzhou, China, Columbia University Medical Center, New York, NY, USA.

  • 11:00 AM 394. Organotypic Breast Tumor Model Enables Drug Screening Against Tumor-Stromal Interactions. Hossein Tavana, PhD, University of Akron, Akron, OH, USA.

  • 11:15 AM 395. Glioblastoma Spheroid Growth, Infiltration, Motility, and Chemotherapeutic Responses in Single and Dual-Stiffness Hydrogels. Shabnam Nejat, B.S., Joseph Bruns, PhD, Silviya Zustiak, PhD, Saint Louis University, Saint Louis City, MO, USA.

  • 11:30 AM 396. Merging Biomaterials and Microscale Technologies to Engineer Ex vivo Organotypic Tumor Microenvironment (TME) Models. Mehdi Nikkhah, Arizona State University, Tempe, AZ, USA.

  • 11:45 AM 397. Microphysiological Prostate Cancer System for in vitro Evaluation of Anti-Cancer Nanotherapeutics. Nicole Habbit, Benjamin Anbiah, Tareq Anani, PhD, Allan David, PhD, Balabhaskar Prabhakarpandian, PhD, Robert Arnold, PhD, Elizabeth Lipke, PhD, Auburn University, Auburn, AL, USA, CFD Research Corporation, Huntsville, AL, USA.

  • 12:00 PM 398. Interrogating Matrix Determinants of Cell Migration Mode and Survival in a Tunable Tumor Stroma Mimetic. Harrison Hiraki, Daniel Matera, PhD, William Wang, PhD, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA.

8C: Engineered Biomaterials for Neural Applications

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Silver Pearl 3

  • 10:15 AM. 399. SHIELD Hydrogels Allow for Long-Term Survival and Integration of Human Cortical Neurons into a Chronic Adult Cervical Spinal Cord Injury. Vanessa Doulames, PhD, Meghan Hefferon, Riley Suhar, PhD, Neil Baugh, Theo Palmer, PhD, Sarah Heilshorn, PhD, Stanford University, Stanford, CA, USA.

  • 10:30 AM 400. Analysis of Lipid Nanoparticle Formulations in a Mouse Model of Traumatic Brain Injury. Katelyn Miyasaki, BS, Lauren Waggoner, Ester Kwon, PhD, University of California San Diego, La Jolla, CA, USA.

  • 10:45 AM 401. DNA-Inspired Electrically Conductive Nanocoating for Intracortical Microelectrode Stimulation and Recording. Ian Sands, Alpaslan Ersoz, PhD, Wuxia Zhang, Libo Zhou, Will Linthicum, Bryan Huey, Martin Han, Yupeng Chen, Sabato Santaniello, Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA, Department of Materials and Science Engineering, University of Connecticut, Storrs, CT, USA.

  • 11:00 AM 402. Cell Specific Spatially Resolved, Multi-Omic Analysis of Intracortical Microelectrode-Tissue Interface. Lindsey Druschel, Sydney Song, Jacob Conard, Jeffrey Capadona, PhD, Case Western Reserve University, Cleveland, OH, USA, Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA.

  • 11:15 AM 403. Multichannel Bridge Implantation and Neural Stem Cell Transplantation to Facilitate Axonal Regeneration, Myelination, and Connectivity After Spinal Cord Injury. Usha Nekanti, Pooja Sakthivel, Atena Zahedi, Rebecca Nishi, Dana Creasman, Xiaoxiao Lin, Zhiling Guo, Xiangmin Xu, Lonnie Shea2, Brian Cummings, Aileen Anderson. University of California, Irvine, Irvine, CA, USA, University of Michigan,, Ann Arbor, MI, USA.

  • 11:30 AM 404. TGF-β1 and PCL Nanofibers to Enhance Schwann Cell Migration. Yang Hu, PhD Candidate, Yin Mei Chan, PhD Candidate, Alan Zhang, Matthew Becker, Rebecca Willits, Northeastern University, Boston, MA, USA, Duke University, Durham, NC, USA.

  • 11:45 AM 405 Design of Cell-Adhesive Guest-Host Hydrogels for Neural Tissue Engineering. Gregory Jensen, Sarah Stabenfeldt, PhD, Julianne Holloway, PhD, Arizona State University, Tempe, AZ, USA.

  • 12:00 PM 406 Glioma-Derived Matrices to Probe Stromal-Matrix Interactions in the Brain Tumor Microenvironment. Chase Cornelison, PhD, University of Massachusetts Amherst, Amherst, MA, USA.

8D: Cardiovascular Biomaterials (SIG)

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Coral 1-2

  • 10:15 AM 407. Mechanical Loading Unveils Calcium Handling Dysfunction in iPSC Micro-Heart Muscle Harboring Hypertrophic Cardiomyopathy Mutations. Jingxuan Guo, David Schuftan, Huanzhu Jiang, Druv Bhagavan, Lavanya Aryan, Nathaniel Huebsch, Washington University in St. Louis, University City, MO, USA.

  • 10:30 AM 408. Microfluidic Bioprinting of Tough Hydrogel-based Vascular Conduits for Functional Blood Vessels. Xiao Kuang, Ph.D., Di Wang, PhD,, Sushila Maharjan, Yu Shrike Zhang, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, USA.

  • 10:45 AM 409. Long-Term Performance of a Biodegradable Elastomer Based Vascular Graft Prepared by Metal Ligand Chelation in Rat/Sheep Carotid Artery Replacement and Pig CABG Models. Ying Chen, Anthony D'Amato, Ayla Musciano, Halle Welch, Cole Latvis, Iwijn Vlaminck,Yadong Wang. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA, 2Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

  • 11:00 AM 410 Integrated Functional Analysis for Engineered Cardiac Organoids Enabled by Artificial Intelligence. Zhen Ma, Andrew Kowalczewski, Shiyang Sun, Plansky Hoang, Syracuse University, Syracuse, NY, USA.

  • 11:15 AM 411. Matrix Mechanics Regulate Engineered Myocardial Microtissue Organization and Contractility. Samuel DePalma, Austin Stis, Darcy Huang, Javiera Jilberto, Christopher Davidson, PhD, Aamilah Chowdhury, Maggie Jewett, Adam Helms, MD, David Nordsletten, DPhil, Brendon Baker, PhD, University of Michigan, Ann Arbor, MI, USA.

  • 11:30 AM 412. Connexin Rich Biomaterials Electrochemically Couple Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Nima Momtahan, Jeanne Stachowiak, Janet Zoldan,The University of Texas at Austin, Austin, , TX, USA.

  • 11:45 AM 413. Hydrogel Assisted Double Molding of 3D Print Reveals Prestress Regulation of MicroHeart Muscle Electrophysiology. Daniel Simmons, David Schuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Mary Munsell, Brennan Kandalaft, Missy Pear, Nathaniel Huebsch, Washington University in St. Louis, St. Louis, MO, USA.

  • 2:00 PM 414. High-Throughput Screening Identifies Hydrogel Conditions for Cardiomyocyte Differentiation and Maturation. Margot Amitrano, William Murphy, University of Wisconsin-Madison, Madison, WI, USA.

8E: Intrinsic and Extrinsic Factors Influencing the Tissue-Biomaterial Interface

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Coral 3-4

  • 10:15 AM. 415. Novel Targeted Treatment of Coagulase-Mediated S. aureus Biofilms. Grant Scull, BS, Adrian Aligwekwe, Drew Koch, DVM, MS, Diplomate ACVS, Kimberly Nellenbach, PhD, Jennifer Sollinger, MS, Jessica Gilbertie, DVM, PhD, MS, Lauren Schnabel, DVM, PhD, Diplomate ACVS, Diplomate ACVSMR2, Ashley Brown, PhD, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA, North Carolina State University, Raleigh, NC, USA.

  • 10:30 AM 416. Efficacy of Saline Wash Plus Vancomycin/Tobramycin-Doped PVA Composite (PVA-VAN/TOB-P) in a Mouse Pouch Infection Model Implanted with 3D-Printed Porous Titanium Cylinders. David Markel, MD, Therese Bou-Akl, MD., PhD, Paula Dietz, MS, Bin Wu, MD, Weiping Ren, MD., PhD, Ascension Providence Hospital, Southfield, MI, USA, Wayne State University, Detroit, MI, USA, Virotech Co., Inc., Troy, MI, USA.

  • 10:45 AM 417. Peptidomimetic Polyurethanes Inhibit Bacterial Biofilm Formation and Disrupt Surface Established Biofilms. Abraham Joy, Apoorva Vishwakarma, Zixi Chen, University of Akron, Akron, OH, USA.

  • 11:00 AM 418. A Thy-1 Negative Inflammatory Fibroblast Subpopulation Emerges as a Key Determinant of Fibrotic Outcomes to Biomaterials. Daniel Abebayehu, PhD, Blaise Pfaff, Grace Bingham, Andrew Miller, Donald Griffin, PhD, Thomas Barker, PhD, University of Virginia, Charlottesville, VA, USA.

  • 11:15 AM 419. The Surface Topography of Silicone Breast Implants Mediates the Foreign Body Response in Mice, Rabbits, and Humans. Joshua Doloff, PhD, Johns Hopkins University, Baltimore, MD, USA.

  • 11:30 AM 420 Dynamic Profiling of Inflammatory Protease Biomarkers in Subcutaneous Host Response to Implanted Biomaterials. Thi Hong Anh Truong, Nam Nam, Tram Dang, PhD, Nanyang Technological University, Singapore, Singapore.

  • 11:45 AM 421. The Role of Toll-Like Receptor 2 and 4 in the Innate Immune Cell Response to Biomaterials and the Foreign Body Response. Brittany Thompson, MS, Leila Saleh, PhD, Stephanie Bryant, PhD, University of Colorado, Boulder, Boulder, CO, USA.

  • 12:00 PM 422. Attenuated Foreign Body Response to Subcutaneous Implants in Regenerative Spiny Mice. Michele Dill, Janak Gaire, PhD, Valentina Supper, Erika Moore, PhD, Chelsey Simmons, PhD, University of Florida, Gainesville, FL, USA.

8F: Advances and Translation of Self-Assembly Soft Biomaterials

8G: Pediatric Drug Delivery and Device Design

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Seaglass

  • 10:15 AM. 430. INVITED SPEAKER .

  • 10:45 AM 431. Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta During Pregnancy. Kelsey Swingle, Michael Mitchell, PhD, University of Pennsylvania, Philadelphia, PA, USA.

  • 11:00 AM 432. Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. Rohan Palanki, Sourav Bose, Apeksha Dave, Brandon White, Kelsey Swingle, Margaret Billingsley, William Peranteau, Michael Mitchell, University of Pennsylvania, Philadelphia, PA, USA, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

  • 11:15 AM 433. Delivery of Decorin via Microspheres to Inhibit Fibrosis in Pediatric Vocal Folds. Ryan Friedman, Elizabeth Brown, Matthew Aronson, Karen Zur, MD, Riccardo Gottardi, PhD, University of Pennsylvania, Philadelphia, PA, USA, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

  • 11:30 AM 434. Antimicrobial Peptide Eluting Endotracheal Tubes Prevent Subglottic Stenosis in a Mouse Model. Matthew Aronson, Amrita Mehta, Ryan Friedman, Daniel Ghaderi, Ryan Borek, MD, Hoang Nguyen, MD, PhD, Kendra McDaid, Natasha Mirza, MD, Ian Jacobs, MD, Riccardo Gottardi, PhD, University of Pennsylvania, Philadelphia, PA, USA, Children's Hospital of Philadelphia, Philadelphia, PA, USA, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA.

  • 11:45 AM 435. Development of a Geometrically Tunable Blood Shunt for Pediatric Heart Reconstruction Surgery. Victor Mishin, Shreya Soni, Akari Seiner, Amy Throckmorton, Christopher Rodell, Drexel University, Philadelphia, PA, USA.

  • 12:00 PM 436. Pediatric Gummy Formulations for Drug Resistant Tuberculosis. Kelsey Broderick, Morteza Mostashari, Melissa Wright, Nikolai Braun, PhD, Lindsay Woodard, PhD, Luna Labs USA, Charlottesville, VA, USA.

8H: Nature Bioinsprired Biomaterials and Strategies for TERM

Timeslot: Saturday, April 22, 2023 - 10:15am to 12:15pm
Room: Shorebreak

  • 10:15 AM. 437. INVITED SPEAKER .

  • 10:45 AM 438. Mussel Inspired Nanoparticles for Mucoadhesion. Arianna Avellán Jaramillo, Kelsey DeFrates, Phillip Messersmith, PhD, University of California, Berkeley, CA, USA.

  • 11:00 AM 439. Electroactive Gelatin Composites for Flexible Biodevices and Tissue Engineering. Anne Brooks, Vamsi Yadavalli, PhD, Virginia Commonwealth University, Richmond, VA, USA.

  • 11:15 AM 440. Cell-Secreted Extracellular Matrix Modulates Expression of Osteogenic Markers in iPSC-MSC Spheroids. David Ramos-Rodriguez, PhD, Shierley Fok Lau, Jonathan Leach, PhD, University of California Davis, Davis, CA, USA.

  • 11:30 AM 441. Toward Quantifying Silk Scaffold Degradation Rates in vivo. Julie Jameson, Henry Lutz, Nisha Kotta, Jonathan Grasman, Whitney Stoppel, University of Florida, Gainesville, FL, USA, UES, Inc, Dayton, OH, USA, Biotechnology Branch, Airman Biosciences Division, 711th Human Performance Wing, Airforce Research Laboratory, Dayton, OH, USA, New Jersey Institute of Technology, Newark, NJ, USA.

  • 11:45 AM 442 Evaluating Therapeutic Potential of Silk Fibroin Nanoparticles for Intravenous Oxygen Delivery. Marisa Pacheco, Jostin Armada, Hannah Bagnis, Bruce Spiess, Whitney Stoppel, PhD, University of Florida, Gainesville, FL, USA.

  • 12:00 PM 443 Characterization and Digital Light Processing of a Hydrolytically Degradable Hyaluronic Acid Hydrogel. Abhishek Dhand, Jonathan Galarraga, PhD, Bruce Enzmann, III, Jason Burdick, PhD, University of Pennsylvania, Philadelphia, PA, USA, University of Colorado, Boulder, Boulder, CO, USA.