2A: PANEL: Freedom-to-Fail Culture Drives Innovation in Biomaterial Research

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: Grand Ballroom
Session Type: Panel Discussion

Description

Every great research advance was paved by countless failed experiments. Indeed, the greatest innovative leaps in science have had an equally great risk of failure. As such, fear of failure may be the greatest deterrent to research progress due to missed opportunities. In this panel of respected biomaterial scientists, we will discuss how to promote a freedom-to-fail culture, fail quickly to increase progress, and embrace failure as the path to success.

Moderators:

Elizabeth Cosgriff-Hernandez, The University of Texas at Austin

Speakers

2B: Biomaterial-Mediated Immune Modulation for Autoimmunity Treatment

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: 4D
Session Type: General Session

Description

Autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, affect over 24 million Americans and are among the leading causes of disability and death in the United States, disproportionately impacting women. A broad spectrum of biomaterials has been engineered to address autoimmunity by modulating immune responses via several mechanisms, such as delivering immunosuppressive drugs, inducing anti-inflammatory reactions, and enhancing regulatory immune cell functions. The proposed session aims to showcase recent studies that utilize biomaterial design to foster tolerogenic responses in the treatment of autoimmune and inflammatory conditions.

Moderators:

Yaoying Wu, Syracuse University
Era Jain, Syracuse University

Objectives

  • 2:45 PM. 43. Injectable hydrogels for localized induction of regulatory T cells. Kenneth Kim, MS1, Lindsay Hager2, Arielle D'Elia, MS2, Christopher Rodell, Ph.D.2 1Drexel University College of Medicine, 2Drexel University

  • 3:00 PM. 44. Localized versus Systemically Delivered Immunomodulation for Treatment of Psoriasis. Jennifer Simonovich, MS1, Sabrina Macias, PhD1, Arun Wanchoo, PhD1, Dorina Avram, PhD2, Gregory Hudalla, PhD1, Benjamin Keselowsky, PhD1 1University of Florida, 2Moffitt Cancer Center

  • 3:15 PM. 45. Antigen-Conjugated Scaffolds for Enrichment of Disease-Specific T-cells. Sydney Wheeler, MSE1, Mary Dickenson, MSE1, Samantha Lukpat, BSE1, Leon Wagner, MSE1, Aaron Morris, PhD1 1University of Michigan

  • 3:30 PM. 46. Iron-Dexamethasone Nanoparticles Prevent Neutrophil Activation in Acute Lung Injury. Michael Felder1, Valentina Guevara1, Daniel Kupor1, Lola Eniola-Adefeso2 1University of Michigan, 2University of Chicago, Illinois

  • 3:45 PM. 47. Macroporous Gelatin Scaffolds Enable Lymph Node Stromal Cell Delivery for T-cell Immunomodulation and Recirculation in Type 1 Diabetes Mouse Models. Leonor Teles, BS1, Zachary Wilkes, BS1, Ana Hernandez, BS1, Logan Beatty, BS1, Camillo Bechi Genzano, MD2, Remi Creusot, PhD2, Alice Tomei, PhD1 1University of Miami, 2Columbia University

  • 4:00 PM. 48. Microneedle Targeting of the Immunological Niche in Skin to Induce Antigen-Specific Immune Tolerance and Counter Autoimmunity.Robert Oakes, PhD1, Shrey Shah, MS2, Camilla Edwards2, Senta Kapnick, PhD2, Christopher Jewell, PhD2 1University of Delaware, 2University of Maryland

2C: Cardiovascular Biomaterials SIG

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: BLVD A
Session Type: General Session

Description

The Cardiovascular Biomaterials Special Interest Group has the mission to foster the professional interaction and address the common concerns of academic and industrial scientists and engineers, clinicians, and regulatory professionals concerned with the discovery, research, development, and use of biomaterials for cardiovascular devices and implants. This includes a broad range of cardiovascular biomaterial strategies used to guide stem cell differentiation, terminally-differentiated vascular cell phenotype, antibacterial properties, and inflammation and remodeling in vivo.

Moderators:

Jessica Gluck, North Carolina State University
Chris Baschur, Florida Institute of Technology

Objectives

  • 2:45 PM. 49. Hydrogel-Mediated Ablation to Improve Safety and Efficacy of Arrhythmia Treatment.Derek Bashe1, Archita Duvvada1, Mathews John2, Drew Bernard2, Lukas Jaworski2, Allison Post2, Mehdi Razavi2, Elizabeth Cosgriff-Hernandez, PhD1 1University of Texas at Austin, 2Texas Heart Institute

  • 3:00 PM. 50. Microfabricated Anisotropic Cardiac Microbundles for the Modular Assembly of Cardiac Tissue Grafts.Maggie Jewett1, Siddhi Bhirud1, Susan Xi1, Amanda Bluem1, Samuel DePalma, PhD2, Brendon Baker, Ph.D.1 1University of Michigan, 2Broad Institute

  • 3:15 PM. 51. Induced Pluripotent Stem Cell-Derived Microtissues Modulate Inflammation to Improve Cardiomyocyte Engraftment and Cardiac Function in a Rat Myocardial Infarction Model.Ramak Khosravi, MD PhD1, Yimu Zhao, PhD2, Krisco Cheung, BSc3, Gordana Vunjak-Novakovic, PhD4, Milica Radisic, PhD2 1University Health Network, 2University of Toronto, 3UC Berkeley-UCSF, 4Columbia University

  • 3:30 PM. 52. Short and long term of hiPSC-CM culture on cardiac ECM microspheres.Jiazhu Xu1, Nick Rogozinski2, Joel Aboagye2, Sarah Velez2, Yufeng Wen1, Angello Gomez2, Zui Pan1, Ge Zhang3, Huaxiao Yang2, Yi Hong1 1The University of Texas at Arlington, 2University of North Texas, 3University of Akron

  • 3:45 PM. 53. The influence of hyperlipidemia on magnesium biocorrosion in vitro and in vivo.Carolyn Czerniak1, Mitchell Connon1, Erico Freitas, PhD2, Henry Summers2, Roger Guillory, PhD1 1Medical College of Wisconsin, 2Michigan Technological University

  • 4:00 PM. 54. Impact of Elemental Compositions of Magnesium Alloys on Ex Vivo and In Vitro Thrombosis.Cole Baker, BS1, Jeremy Goldman, PhD2, Jennifer Johnson3, Monica Hinds, PhD4, Deirdre Anderson, PhD4 1Oregon Health and Science University, 2Michigan Tech, 3ONPRC, 4OHSU

2D: Dental/Craniofacial Biomaterials SIG 2

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: BLVD C
Session Type: General Session

Description

The Dental/Craniofacial Biomaterials Special Interest Group focuses on basic, applied, and clinical biomaterials research using approaches ranging from synthetic materials to biological mechanisms of therapy, and including materials/biological constructs and tissue structure-function analyses as biomimetic/design bases. Each of these approaches converge into the larger objective of restoring oral tissue structure and function. Issues related to materials used or having potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region are included. New dental biomaterials technologies include advanced inorganic and organic materials, biomimetics, smart materials, tissue engineering, drug delivery strategies and surface modified materials.

Moderators:

Daniel Harrington, The University of Texas Health Science Center at Houston
Brandon M. Nitschke, Texas A&M University
Christine Knabe, Dept. of Experimental Orofacial Medicine, Philipps University Marburg

Objectives

  • 4:00 PM. 55. Characterization of 3D Printed Titanium Alloy with Channels (Ti-6Al-4V) for Craniofacial Applications.Ashley Cahoon, B.S.1 1Illinois Institute of Technology

  • 2:45 PM. 56. Cyclic Loading of Biomaterials Enhances Virulence of Oral Pathogens.Carolina Montoya, PhD1, Julia Kurylec1, Santiago Orrego1 1Temple University

  • 3:00 PM. 57. Designing Antibacterial and Antifungal Dental Resins for 3D-Printed Dentures Using Imidazolium-based Ionic Liquids.Isadora Garcia, DDS, MSc, PhD1, Tasneem Alluhaidan, BDS, GAGS1, Mary Anne Melo, DDS, M.Sc, PhD, FADM, FACD1, Masoumah Qaw, BDS, MSD1 1School of Dentistry, University of Maryland Baltimore

  • 3:15 PM. 58. Resveratrol modulates Hedgehog signaling pathway and increases the osteogenic commitment of periodontal ligament mesenchymal cells..Denise Andia1, Rahyza de Assis2, Francesca Racca3, Rodrigo da Silva1, Malgorzata Wiench4, Rogério Ferreira1 1Paulista University, 2Federal University of Espírito Santo., 3The Ohio State University College of Dentistry., 4University of Birmingham.

  • 3:30 PM. 59. Structure and Morphology of Calcium Phosphates Obtained from a Flowable Dental Composite Stored in Simulated Body Fluid and Artificial Saliva.Piotr Psuja1, Erick Yu1, Byoung I Suh1 1BISCO

  • 3:45 PM. 60. Formulation screening of optimized photoinitiator systems for photopolymerized dental resins.Afnan Al-Zain, BDS, MSD, PHD1, Richard Price, BDS, DDS, MS, FDS RCS, FRCD(C), PhD2, Eman Ismail, BDS, MSD, PHD3, Abdulrahman Balhaddad, BDS, MSD, PHD4, Jeffery Platt, DDS, MS5, Mary Anne Melo, DDS, M.Sc, PhD, FADM, FACD6 1King Abdulaziz University, 2School of Biomedical Engineering, Faculty of Medicine, 3Princess Nourah Bint Abdulrahman University, 4Imam Abdulrahman Bin Faisal University, 5Indiana University School of Dentistry, 6School of Dentistry, University of Maryland Baltimore

2E: Engineering Heart and Lung Models to Study Disease Progression and Therapeutic Development

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: BLVD B
Session Type: General Session

Description

This session focuses on leveraging biomaterials to create models of the heart and lung, including engineered tissues, organoid, and/or organs-on-a-chip, and how these systems can be leveraged to understand disease processes and as a testbed to identify and test potential therapeutics. These models can be used to develop treatments for acute conditions such as virus infections, to investigate mechanisms of chronic disease progression, for toxicology testing, and overcome the limitations of animal models used for cardio-pulmonary research. Approaches that combine in vitro models with state-of-the-art techniques for phenotyping, including bulk and spatially resolved omics technologies and cutting-edge data analysis and visualization such as machine learning are also encouraged

Moderator:

Claudia Loebel, University of Michigan

Objectives

  • 2:45 PM. 61. Development of an engineered heart tissue platform to study the progressive tissue stiffness change in hypertrophic cardiomyopathy.Ganesh Malayath1, Huanzhu Jiang1, Ghiska Ramahdita1, Yasaman Kargar Gaz Kooh1, Nathaniel Huebsch, PhD1 1Washington University in St. Louis

  • 3:00 PM. 62. Modeling Cardiomyocyte-fibroblast Crosstalk in Hypertrophic Cardiomyopathy Pathogenesis using iPSC-derived Micro Heart Tissue.Huanzhu Jiang1, Ganesh Malayath1, Ghiska Ramahdita1, Yasaman Kargar Gaz Kooh1, Sharon Cresci1, Nathaniel Huebsch, PhD1 1Washington University in St. Louis

  • 3:15 PM. 63. High Throughput Fabrication of Human Engineered Heart Tissues for Modeling of Pathological Cardiac Hypertrophy.Abhishek Dhand1, Miranda Juarros2, Thomas Martin2, Leslie Leinwand2, Jason Burdick2 1University of Pennsylvania, 2University of Colorado, Boulder

  • 3:30 PM. 64. Multilayered Cardiac Microtissues for Dissecting Homeostatic vs. Fibrotic Intercellular Communication.Emmanouil Agrafiotis, PhD1, Samuel DePalma, PhD2, Darcy D. Huang3, Anya G. Coffeen Vandeven1, Austin E. Stis4, Jingyi Xia1, Brendon Baker, Ph.D.1 1University of Michigan, 2Broad Institute, 3University of P, 4University of Florida

  • 3:45 PM. 65. Epithelial Cell-Specific Nascent Matrix Deposition Directs Cell Differentiation within the Lung.Donia Ahmed1, Matthew Tan, Ph.D.1, Jingyi Xia1, Brendon Baker, Ph.D.1, Claudia Loebel, M.D., Ph.D.1 1University of Michigan

  • 4:00 PM. 66. Heightened matrix fiber density drives aberrant angiogenesis to propagate fibrotic signaling.William Wang, PhD1, Jingyi Xia1, Kyle Jacobs, MS2, Ariella Shikanov, Ph.D.1, Matthew Kutys, PhD2, Brendon Baker, Ph.D.1 1University of Michigan, 2UCSF

2F: High Performance Biomaterials for Tissue Engineering and Regenerative Medicine

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: Joliet
Session Type: General Session

Description

Biologically derived polymers and composites offer excellent opportunities in the biomaterials field. This versatile class of materials includes biopolymers (polyhydroxy alkanoates, hyaluronic acid), polysaccharides (starch, chitin/chitosan, alginate) or proteins (collagen, fibrin, silk fibroin) enabling developing engineered systems with outstanding biological performance. The innovative use of its characteristics, taking advantage of the similar structure or composition with respect to biological tissues, enables designing high performance solutions for biocompatibility, biodegradability and bioactivity of biomaterials. Also the advanced areas of tissue engineering, drug delivery and smart/active/adaptive systems may benefit from the wealth of natural polymers existing in nature.

Moderator:

Nuno Neves, University of Minho

Objectives

  • 3:15 PM. 71. Porous Semisynthetic Hyaluronic Acid Cryogel Scaffolds Promote Muscle Regeneration.Kavita Parekh1, Sydney Shriver2, Kiersten Russ3, Luke Langford1, Aboubacar Wague4, Sankalp Sharma4, Xuhui Liu, MD4, Brian Feeley, MD4, Ahmad Omar, PhD1, George Christ, PhD2, Kevin Healy, PhD1 1University of California, Berkeley, 2University of Virginia, 3University of California, Los Angeles, 4University of California, San Francisco

  • 3:30 PM. 72. Bioprinted Porous Collagen I Scaffold to Enhance Proximal Tubule Maturation Under Physiologic Shear.Brian Coffin, Ph.D.1, Joshua Tashman, MD, PhD1, Cary Boyd-Shiwarski, MD, PhD1, Daniel Shiwarski, Ph.D.1 1University of Pittsburgh

  • 3:45 PM. 73. Design and Fabrication of Channelized Nerve Guidance Conduits for Peripheral Nerve Regeneration.Lohitha Hegde1, Jeremy Perrelle2, Andrew Boreland3, Timothee Baudequin4, Fahmi Bedoui4, Zhiping Pang3, Sanjeeva Murthy3 1University of Compiegne, 2Robert Wood Johnson Medical School, 3Rutgers University, 4Universite de Technologie Compiegne

  • 4:00 PM. 74. High-Throughput In Vivo Screening of Biomaterials.Fan Zhang1 1University of Washington

Speakers

2G: Immune Engineering SIG 1

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: Marquette
Session Type: General Session

Description

Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy (immune-modulation), cell and gene therapy, immune microenvironment engineering, and systems immunology. These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.

Moderator:

Xiao Huang, Drexel Univeristy

Objectives

  • 2:45 PM. 75. Implantable biomaterial microporous scaffolds predict food allergy severity as a surrogate of immune dynamics in the gastrointestinal tract.Laila Rad, MSE1, Russell Urie, PhD1, Michael Saunders, BS1, Jessica O'Konek, PhD1, Lonnie Shea1 1University of Michigan

  • 3:15 PM. 76. Targetless Immunotherapy Rescues Mice From LPS-Induced Septic Shock.Helena Freire Haddad1, Pablo Cordero Alvarado1, Maria Kulapurathazhe1, Emily Roe1, Vinicius Xie Fu1, Joel Collier, PhD1 1Duke University

  • 3:30 PM. 77. Immunomodulatory cytokine factories prevent foreign body response against encapsulated islets and delay the onset of diabetes..Boram Kim1, Amanda Nash2, Yuen San Chan3, Samantha Fleury4, Shravani Deo5, Danna Murungi4, Courtney Hodges3, Omid Veiseh4, Dilrasbonu Vohidova4 1MIT, 2MaKinsey, 3Baylor College of Medicine, 4Rice University, 5N/A

  • 3:45 PM. 78. Placental Mimicry Cell Therapy Delays Bystander Cell Rejection in Xenotransplant Model.Shivani Hiremath, MS1, Chishiba Chilimba, MS1, JESSICA WEAVER, PhD1 1Arizona State University

  • 4:00 PM. 79. Localized Delivery of Indoleamine-2,3-Dioxygenase (IDO) - Galectin 3 Fused Enzyme Using Decellularized Sciatic Nerve for Injured Spinal Cord Immune Modulation and Regeneration.Allison Campbell, B.S.1, Gopal Agarwal, PhD1, Arun Wanchoo, PhD1, Prodip Bose, PhD1, Gregory Hudalla, PhD1, Benjamin Keselowsky, PhD1, Christine Schmidt, PhD1 1University of Florida

  • 3:00 PM. 80. Nanoimmunomaterials from the Johns Hopkins Translational ImmunoEngineering Center Enable Immune Cell Specific Targeting.Jordan Green, Ph.D.1 1Johns Hopkins University

2H: Three Minute Thesis

Date: Wednesday, April 9, 2025
Time: 2:45 PM to 4:15 PM
Room: 4C
Session Type: General Session

Description

In a 3-Minute Thesis (“3MT”) Competition, students present a single static slide as a compelling summary of their dissertation research and its broader impacts. Presentations must be at most three minutes. 3MT is a great way to think about how to convey the significance of your work.