3A: PANEL: Biomaterials and Medical Products Entrepreneurship & Commercialization

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: Grand Ballroom
Session Type: Panel Discussion

Description

This session will be a moderated panel discussion covering end-to-end aspects of translational biomaterials research with an emphasis on entrepreneurship and commercialization experiences in developing medical products.

Panelists will share stories related to translating biomaterials from the lab to the clinic, including topics focused at the intersection of material science, machine learning, and manufacturing. The panel will also highlight how business acumen in securing investors, leveraging government and other support sources, and building your team impact translational outcomes.

In a 2 hour session, the first half would focus the discussion on predetermined questions for the panelists, and the second half would focus on discussing questions from the audience. The panel is expected to include, but is not limited to, an academic entrepreneur, a clinician, a non-profit contract researcher, a commercial entrepreneur, and a regulator.

Moderators:

Kenneth Sims Jr, Battelle
Sarah Stabenfeldt, Arizona State University

Speakers

3B: Advanced Applications and Novel Methods in 3D Bioprinting 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: 4D
Session Type: General Session

Description

3D bioprinting has emerged as a leading biofabrication technique to both engineer tissues for regenerative medicine and create microphysiological models for drug screening and personalized medicine. This symposium will focus on advances in 3D bioprinting methods ranging from hardware design, AI-based software, multifunctional biomaterials, and novel bioink formulations. Specific attention will be given to open-source technological advances driving the rapid innovation and widespread adoption, as well as current challenges and future strategies towards commercialization of bioprinted medical devices. We will additionally highlight new developments from industry, 4D bioprinting, and cover examples of in vivo bioprinting. Our goal is to assimilate novel methods in mechanical design, software analysis, materials development, and medical device construction to encourage the next wave of 3D printing innovation.

Moderators:

Gulden CamciUnal, Univeristy of Massachusetts Lowell
Daniel Shiwarski, University of Pittsburgh

Objectives

  • 8:00 AM. 82. Ultrafast Nanofiber 3D Printing of Polycaprolactone Scaffolds.Ievgenii Liashenko, Ph.D.1, Simon Luposchainsky2, Alberto Ramon1, Huaizhong Xu2, Paul Dalton1 1University of Oregon, 2Kyoto Institute of Technology

  • 8:30 AM. 83. Caner Dikyol, MS1, Will O'Brien1, Maria Stang, PhD1, Durva Naik, PhD1, Faaz S. Ashraf, MD1, Adam Feinberg, Ph.D.1 1Carnegie Mellon University

  • "8:45 AM. 84. An Embedded Bioprinting Approach for Engineering Biochemical Heterogeneity in 3D Scaffolds:
    Toward Complex Tissue Interfaces.Murat Guvendiren1 1New Jersey Institute of Technology"

  • 9:00 AM. 85. Development of a Novel Hybprinter-SAM for Functionally Graded Tissue Engineering Constructs with Patterned and Localized Biochemical Signals.Jiannan Li1, Carolyn Kim1, Hossein Alizadeh1, Yunzhi Peter Yang1 1Stanford University

  • 9:15 AM. 86. Digital Light Processing 3D Printing of Microgel-Reinforced Hydrogels.Cody Crosby, Ph.D.1, Abhishek Dhand2, Jonathan Taasan, B.S.3, Jason Burdick4 1Southwestern University, 2University of Pennsylvania, 3University of Colorado Boulder, 4University of Colorado, Boulder

  • 9:30 AM. 87. IN4MER Bioink: A Single-Modality Biosensing Bio-ink for Multianalytes and Temperature Monitoring Applications.Waqas Saleem1, David Chimene1, Berkley White1, Kaivalya Deo2, Jeremy Thomas3, Nithin Chidambara1, Cole Mandrona1, Kirsten Landsgaard4, Brian Ko1, Roland Kaunas1, Akhilesh Gaharwar1, Michael McShane1 1Texas A&M University, 2Axent Biosciences, 3Duke University, 4TAMU

  • 9:45 AM. 88. High Throughput Screening of Patient-Derived Breast Cancer with Improved Physiological Relevance by Basement Membrane Matrix for Clinical Application.Wonwoo Jeong, PhD1 1Wake Forest Institute for Regenerative Medicine

Speakers

3C: Antimicrobial Biomaterials 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD C
Session Type: General Session

Description

Due to the threat of antibiotic resistance, biofilms, and the risk of implant-associated infections, strategies for pathogen inactivation play an increasingly important role in biomaterials development. Antimicrobial biomaterials, drug delivery systems, and surfaces that eradicate biofilms and prevent biofilm formation can prevent implant failure, improve clinical outcomes, and reduce treatment costs. This session will cover topics related to designing and characterizing biomaterials to control bacterial, viral, and/or fungal responses. Topics relating to the study of biocompatibility of pathogen-resistant surfaces; the selection and use of in vitro and preclinical models of infection; understanding the roles of biomaterials, pathogens, and hosts in biomaterial-associated infections; and the use of the One Health approach to design biomaterials to combat infections that negatively impact human, animal, and environmental health are also invited.

Moderators:

J. Amber Jennings, The University of Memphis
Mary Beth Monroe, Syracuse University
Anita Shukla, Brown University

Objectives

  • 8:00 AM. 89. Wound Healing Promoted by Broad-Spectrum, Phage Structure Mimicking, Synthetic Antibacterial Nanoparticles , which Cleared MDR ESKAPE Pathogens Induced Infections in Wound Models.prakash nallathamby, PhD1, prakash nallathamby, PhD1, prakash nallathamby, BS1 1University of Notre Dame

  • 8:15 AM. 90. Antibiofilm Properties of Polyurethane Biomaterials Tethered with Small Molecules via Polyethylene Glycol (PEG).Lichong Xu1, Jiale Liu2, Chen Chen2, Christopher Siedlecki1 1Penn State College of Medicine, 2Penn State University

  • 8:30 AM. 91 .Coacervate Dense Phase Displaces Surface-Established Pseudomonas aeruginosa Biofilms.Abraham Joy1, Apoorva Vishwakarma2, Amal Narayanan, N/A3, Zixi Chen, N/A4, Francis Dang, N/A2, Joshua Menefee5 1Northesatern University, 2Food and Drug Administration, 3University of Florida, 4E Ink Corporation, 5The University of Akron

  • 8:45 AM. 92. Enhancing infected wound regeneration using self-locomotive, antimicrobial micro-bubblers.Yujin Ahn1, Joo Hun Lee1, Christian Hurd1, Deborah Zhang1, Hyunjoon Kong1 1University of Illinois at Urbana-Champaign

  • 9:00 AM. 93. Antimicrobial Metallopolymer to Resensitize Antibiotics Against Gram-negative Superbugs.Md Waliullah Hossain1, JiHyeon Hwang1, Swagatam Barman1, Chuanbing Tang1 1University of South Carolina

  • 9:15 AM. 94. Augmenting Ischemic Wound Healing Through Peroxide Decomposition.Ayden Watt, MSc1, Benjamin Dallison, PhD1, Nitin chandra teja Dadi, PhD1, Nicholas Makhoul, DMD, MD, FRCD(C)1, Mirko Gilardino, MD, MSc, FRCSC, FACS1, Jake Barralet, PhD1 1McGill University

  • 9:30 AM. 95. Covalent conjugation of Tanfloc on Titania Nanotube surface Enhancing Antibacterial Properties.Ramesh Singh1, Ketul Popat1 1George Mason University

  • 9:45 AM. 96. Eradication of Staphylococcus aureus Biofilm on Polyethylene when Paired with a Mixed Metal Electrode Using Cathodic Voltage-Controlled Electrical Stimulation and Subsequent Alkaline Incubation.kevin McPhillips, PhD1, Menachem Tobias, MS1, Mark Ehrensberger, PhD1 1University at Buffalo

3D: Biomaterials for Neural Engineering

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD B
Session Type: General Session

Description

Engineered biomaterials are uniquely positioned for use in creating, testing, stimulating, and regenerating neural tissue with applications like in vitro models of injury and disease, tissue engineering, therapeutic treatments, understanding neural development, and mapping or recording the brain. This session will focus on cutting edge research in neural biomaterials including fundamental material development and fabrication through pre-clinical and clinical studies spanning materials from small molecules to extracellular mimetics to neural interfaces. Such materials may be applied to big questions surrounding understanding and treating diseases and injuries of the peripheral and central nervous systems including drug, biologic, and therapeutic delivery or interventions.

Moderators:

Kyle Lampe, University of Virginia
Sarah Stabenfeldt, Arizona State Univeristy
Tim O'Shea, Boston University

Objectives

  • 8:30 AM. 98. Glycan Functionalized Biomaterials for Modulating Neuroinflammation and Tissue Repair Post Ischemic Stroke.Yunxin Ouyang1, Tatiana Segura, PhD1 1Duke University

  • 8:45 AM. 99. Injectable Bioactive Polypeptide Scaffold Enhances Angiogenesis for Peripheral Nerve Repair.Emily Song1, Rachael Putman2, Ashutosh Chilkoti, PhD2 1Duke University, 2Duke

  • 9:00 AM. 100. Guiding oligodendrocyte progenitor cell maturation using electrospun fiber cues in a 3D amorphous hydrogel.Rachel Mazur, PhD1, Kyle Lampe, PhD1 1University of Virginia

  • 9:15 AM. 101. Studying Tenascin-C Effects on Enhancing Neuronal Axonal Alignment in 3D-Printed Hydrogel Scaffolds.Rounak Pokharel1, Nic Leipzig, Dr.1 1University of akron

  • 9:30 AM. 102. Temporospatial Sensitive Nanoprobe for Traumatic Brain Injury.David Flores-Prieto1, Amanda Witten, M.S.1, Rachael Sirianni, PhD2, Sarah Stabenfeldt, PhD1 1Arizona State University, 2UMass Chan Medical School

  • 9:45 AM. 103. Studying astrocyte borders using injectable biomaterials.Timothy O'Shea, PhD1, Eric DuBois, MS1 1Boston University

Speakers

3E: Biomaterials in Biomedicine: Diagnostics, Therapeutics, and Wound Care 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD A
Session Type: General Session

Description

This session highlights recent advances in biomaterials for therapeutics, diagnostics, and biodevices focusing on hemostasis, thrombosis, mechanobiology, and wound healing. Addressing these complex injuries necessitates advanced therapeutic strategies that promote hemostasis, manage infections and wound healing, and provide tissue regeneration. Current treatments for high-energy trauma are inadequate for addressing the extensive tissue damage and infections often associated with these injuries. Through this symposium, we seek to demonstrate the significant clinical potential of problem-focused therapy as a rational solution for improving healing outcomes, rapid and effective tissue regeneration, and robust infection control, leading to improved quality of life for both military personnel and civilians.

Moderators:

Zainab Jabbari Velisdeh, Louisiana Tech University
Gaurav Pandey, Louisiana Tech University

Objectives

  • 9:30 AM. 104. Sea Squirt-inspired Bio-derived Tissue Sealants.Sean Murray1 1Purdue University

  • 8:00 AM. 105. Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Simin Belali, PhD in Organic- Polymer Chemistry1, Sergei Vinogradov, PhD1, Marien Iliza Ochoa Mendoza, PhD2, Matthew S. Reed, Master in science2, Annemarie Lang, PhD1, Brian W. Pogue, PhD2 1University of Pennsylvania, 2University of Wisconsin-Madison

  • 8:15 AM. 106. Advanced Biomaterial Scaffolds for Rapid Pathogen Identification: Enabling Ultra-Sensitive Blood Drying.Jongwon Lim1, Rashid Bashir1 1university of Illinois at Urbana-Champaign

  • 8:30 AM. 107. Topical Exosome-Loaded Gel for the Antibiotic Treatment of Wound Infections.Melissa Wright, ME1, Kate Johnson1, Eric Shuler, MS1, Kelsi Smith1, Christopher Tison, PhD1, Stephen Davis, PhD2, Joel Gil2 1Luna Labs USA, 2University of Miami Miller School of Medicine

  • 8:45 AM. 108. A Novel Peptide Hemostat for Enhanced Platelet Adhesion Leading to Improved Hemostasis.Maithili Joshi1, Kyung Soo Park2, Anujan Ramesh1, Danika Rodrigues1, Griff Bibbey1, Metecan Erdi1, Samir Mitragotri1 1Harvard University, 2Harvard Unversity

  • 9:00 AM. 109. Wound Dressings Capable of Delivering OPN and SDF-1α to Enhance Diabetic Wound Healing.Zhongting Liu, Master1, Ya Guan2, Hong Niu1, Jiaxing Wen, Master1, Li Ye1, Jianjun Guan, PhD1 1Washington University in St. Louis, 2Duke University

  • 9:15 AM. 110. Multifunctional hydrogels as wound dressing materials: In vitro and in vivo evaluations.Muhammad Umar Aslam Khan1, Muhammad Azhar Aslam2, Tooba Yasin3, Humaira Masood Siddiqi3, Anwarul Hasan1 1Qatar University, 2University of Engineering and Technology, 3Quaid-i-Azam University

  • 9:45 AM. 111. A Rotational Shear-Based Device for Fabricating Uniform Hydrogel Microspheres for Prostate Cancer Treatment Using Embolization.Hanieh Shokrani1, Sam Stealey, PhD1, Silviya Zustiak, PhD1 1Saint Louis University

3F: Drug Delivery SIG 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: Marquette
Session Type: General Session

Description

This session will survey the diverse range of contemporary drug delivery systems and innovations. Drug delivering biomaterials can include nanoparticles, hydrogels, nanofibers, cell and virus-derived particles, or bioconjugates. Payloads can include DNA, RNA, antibodies, recombinant proteins, or small molecules. Disease applications can range from neurodegeneration to autoimmune disease, trauma, infection, or cancer. Work at all scales, from basic formulation science through therapeutic application in disease models is welcome. Studies that critically evaluate the impact of injection route on treatment efficacy and/or use novel imaging modalities to evaluate drug delivery performance are especially encouraged.

Moderators:

Matt Webber, University of Notre Dame
Kevin McHugh, Rice University

Objectives

  • 8:00 AM. 116. Indoleamine 2,3-Dioxygenase Enzyme-Peptide Gel for Local Immune Modulation.Madeline Fuchs1, Jennifer Simonovich, MS1, Isabella Pinto1, Gregory Hudalla, PhD1, Benjamin Keselowsky, PhD1 1University of Florida

  • 8:15 AM. 117. A Regimen Compression Strategy Leveraging the Administration Route of an Injectable Hydrogel Depot Technology for Sustained Vaccine Exposure.Jerry Yan1, Leslee Nguyen2, Ibukun Ajifolokun3, Ben Ou, PhD2, Ye Eun Song, M.S.1, Eric Appel, PhD1 1Stanford University, 2Appel Group, Stanford University, 3Stanford

  • 8:30 AM. 118. Poly(beta-amino ester)/poly(lactic-co-glycolic acid) blends for co-delivery of small molecules and proteins to enable locoregional combination therapy of primary liver tumor.Hongzhe Yu1, Ling Li1, Florin Selaru1, Jordan Green, Ph.D.1 1Johns Hopkins University

  • 8:45 AM. 119. Glucose-Stabilized Peptide Assemblies for Glucagon Delivery.Matthew Webber, PhD1, Sihan Yu, PhD1, Weike Chen, PhD1 1University of Notre Dame

  • 9:00 AM. 120. Vaccine Delivery from a TLR7 Agonist-Functionalized Peptide Hydrogel Promotes Robust Humoral and Cellular Immune Responses.Kevin McHugh, Ph.D.1, Erin Euliano, Ph.D.1, Kevin McHugh, Ph.D.1, Kevin McHugh1, Kevin McHugh1, Kevin McHugh1, Tyler Graf1, Jeffrey Hartgerink, Ph.D.1 1Rice University

  • 9:15 AM. 121. Microgel-mediated delivery of decorin prevents pediatric vocal fold scarring.Ryan Friedman, Mr.1, Elizabeth Brown, Ms.1, Hannah Bonelli1, Matthew Aronson, Mr.1, Kendra McDaid, Dr.2, Riccardo Gottardi, Dovtort1 1University of Pennsylvania, 2Children's Hospital of Philadelphia

  • 9:30 AM. 122. Aromatic mRNA lipid nanoparticle platform confers vaccine protection with reduced off-target delivery.Hannah Yamagata, B.S.1, Marshall Padilla, PhD1, Michael Mitchell, Ph.D.1 1University of Pennsylvania

  • 9:45 AM. 123. Lipid nanoparticles targeting smooth muscle cells as a therapeutic platform for ACTA2 genetic vasculopathy of infancy.Eliz Amar Lewis1, Juan Carlos Oliva Estrada2, William Sawyer3, Sabyasachi Das4, Pazhanichamy Kalailingam4, Rashmi Richa4, Joseph Lawton4, Christiano Alves4, Lauren Fox4, Ben P. Kleinstiver4, Patricia Musolino4, Mark E Lindsay4, Natalie Artzi2 1Brigham and Women's Hospital, Haravard Medical School, 2Brigham and Women's Hospital, Harvard Medical School, 3Brigham and Women’s Hospital, Harvard Medical School, 4Massachusetts General Hospital

3G: Novel Biomaterial Developments in Non-Viral Drug Delivery Systems

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: 4C
Session Type: General Session

Description

Nucleic acid-based therapies or genetic medicines have the potential to treat a wide variety of conditions. Heavy reliance on viral methods, however, can hamper clinical translation and widespread use of such therapies. Non-viral approaches are required to avoid the risk of adverse immune reactions, enable redosing, and make nucleic acid-based therapies more affordable. This session will focus on showcasing biomaterials-based approaches to non-viral nucleic acid-based therapies. We encourage contributions spanning a wide range of biomaterials research applications, including the development of novel carrier systems (e.g., polymer- and lipid-based nanocarriers, engineered extracellular vesicles, physical methods, etc.), methods of deployment (e.g., controlled release, novel routes of administration, etc.), and therapeutic cargo (e.g., novel nucleic acid designs, aptamers, etc.), among others.

Moderators:

Daniel Galego-Perez, The Ohio State University
Qiabing Xu, Tufts University

Objectives

  • 8:30 AM. 125. A Green Chemistry Approach to the Synthesis of Ionizable Lipids for Lipid Nanoparticle-Based mRNA Vaccines and Therapeutic Development.Xiaoyang Xu1, Zhongyu Li1 1New Jersey Institute of Technology

  • 8:45 AM. 126. Engineering controlled release from biodegradable drug delivery devices 3D printed with vat polymerization.Hafiz Busari, M.S.1, O. Thompson Mefford, Ph.D.2, Michael Vaughn, Ph.D.3 1Pol-Med, Inc., 2Clemson University, 3Poly-Med, Inc.

  • 9:00 AM. 127. Extracellular Vesicles Facilitate Motor-like Neuron Reprogramming to Support Temporary Muscle Reinnervation After Peripheral Nerve Injury.Ana Salazar Puerta, PhD1, Grant Barringer, Student1, Jon Stranan, MS1, Sara Kheirkhah, BS1, Hallie Harris, MS1, Megumi Fukuda, Student1, Amy Moore, MD1, Dave Arnold, MD2, Daniel Gallego-Perez, PhD1 1The Ohio State University, 2University of Missouri

  • 9:15 AM. 128. Rapid, plate robot-integrated microfluidic generation and validation of large, precisely defined lipid nanoparticle libraries for screening.Andrew Hanna, BA1, Michael Mitchell, Ph.D.1, David Issadore, Ph.D1 1University of Pennsylvania

  • 9:30 AM. 129. Multifunctional Nanoscale Delivery System for Breast Cancer Brain Metastasis.Metin Uz, Ph.D. in Chemical Engineering1, Mohd Ali Abbas Zaidi2, Asad Rehman2, Tugce Dogruel1, Laiba Anwar2, Mahek Fatima2, Md Arafat Khan Arafat Khan2, Parvez Khan3, juan Santamaria2, Mohd Wasim Nasser2 1Cleveland State University, 2University of Nebraska Medical Center, 3u

  • 9:45 AM. 130. A Dendrimer-Based Ultrasound-Responsive Gene Delivery System for Precision Cancer Therapy.Nikita Sehgal, MS1, Kevin Schilling, PhD1, Riccardo Carloni, PhD1, Carolyn Schutt Ibsen, PhD1 1Oregon Health& Science University

Speakers

3H: Tissue Engineering SIG 1

Date: Thursday, April 10, 2025
Time: 8:00 AM to 10:00 AM
Room: Joliet
Session Type: General Session

Description

Tissue Engineering SIG is a forum to exchange information, further knowledge, and promote greater awareness regarding all aspects of the use of biomaterials to engineering tissue substitutes or to promote tissue regeneration. Of primary interest and relevance to TE SIG is the use of appropriate materials (synthetic and natural) with cells (either native or from a donor source) and/or biological response modifiers (e.g., growth factors, cytokines and other recombinant products) to replace tissue and organ functions. Particular emphasis is placed on the development of materials to better incorporate, protect, and deliver both the cells and biological response modifiers to help promote the healing and regenerative processes. The group is committed to forging interactions among basic scientists, applied scientists, engineers, clinicians, industrial members, professional societies in related fields, and regulatory groups in its efforts to expand and effectively utilize the shared knowledge base in this multidisciplinary field.

Moderators:

Woojin Han, Icahn School of Medicine at Mount Sinai
Jeannine Coburne, Worcester Polytechnic Institute
Gulden CamciUnal, Univeristy of Massachusetts Lowell

Objectives

  • 8:00 AM. 131. Aqueous synthesis of poly(ethylene glycol)-norbornene-carboxylate for dynamic hydrogel crosslinking.Nathan Dimmitt1, Chien-Chi Lin, Ph.D.1 1Purdue University

  • 8:15 AM. 132. Extracellular matrix stress relaxation regulates spatiotemporal mammary branching morphogenesis.Ryan Stowers, Ph.D.1, Daniella Walter1, Juliette Moore1, Abhishek Sharma1 1UC Santa Barbara

  • 8:30 AM. 133. IGF-1 mimetic peptide conjugated alginate hydrogels enhance survival and blunt inflammation in Mesenchymal Stromal Cells.Xiaohong Tan, PhD1, Liufang Jing, BS1, Sydney Neal, BS, MS1, Munish Gupta, MD1, Jacob Buchowski, MD1, Lori Setton, PhD1, Nathaniel Huebsch, PhD2 1Washington University in Saint Louis, 2Washington University in St. Louis

  • 8:45 AM. 134. In Vitro Bioengineered Immune-Competent Colons as a Platform to Study Enteric Neuroinflammation and Neuroimmune Crosstalk.Karla Ortega Sandoval1, Claudia Collier2, Aelita Salikhova1, Shreya Raghavn, PhD2 1Texas A&M Univesity, 2Texas A&M University

  • 9:00 AM. 135. Mathematical Modeling of Ligand Interconnectivity Using One-dimensional Magnetic Nanomaterials for Reversible Stem Cell Regulation.Nayeon Kang1, Chowon Kim1, Heemin Kang1 1Korea University

  • 9:15 AM. 136. Patterned siRNA Hydrogels for Spatially Regulating Cell Gene Expression and Driving hMSC Osteogenesis.Cong Huynh1, Minh K. Nguyen2, Nicholas Kwon2, Zachary Flohr2, Melanie Chetverikova2, Eben Alsberg1 1University of Illinois at Chicago, 2Case Western Reserve University

  • 9:30 AM. 137. Sacrificial Endothelialized Microfibers for Engineering Aligned Capillary Beds.Maggie Jewett1, Harrison Hiraki, PhD1, Firaol Midekssa, MS1, Elizabeth Stanley1, Michael Hu, MS1, Siddhi Bhirud1, Susan Xi1, Brendon Baker, Ph.D.1 1University of Michigan

  • 9:45 AM. 138. Photonic manipulation of ligand spacing in supramolecular self-assembly for stem cell regulation.Sungkyu Lee1, Heemin Kang1 1Korea University