5A: PANEL: Navigating Commercialization Challenges of Medical Devices from a Scientist’s Perspective

5B: Orthopaedic Biomaterials SIG 2

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD B
Session Type: General Session

Description

There are increasing demands for orthopedic biomaterials which play critical roles in patient care. This session invites presentations on metals, ceramics, and polymers that are used every day in modern orthopedic applications. Particular focuses will include octacalcium phosphates, bioabsorbable metallic materials, biomaterial degradation and impacts, and additive manufacturing. Applications will span across orthopedic, cardiovascular, craniomaxillofacial implants, etc. In vitro, in vivo, and in silico studies, as well as studies focusing on commercialization and clinical/translational challenges are welcome.

Moderator:

Michael Roach, University of Mississippi Medical Center

Objectives

  • 8:00 AM. 238. Magnesium-tricalcium phosphate-hydroxyapatite Combination Anodization Coatings on Titanium Solid and 3D-printed implant surfaces.Amisha Parekh1, Aya Ali2, Matthew Priddy3, Scott Williamson1, Jason Griggs1, Michelle Tucci1, Amol Janorkar, Ph.D.1, Michael Roach1 1University of Mississippi Medical Center, 2University of North Carolina at Chapel Hill, 3Mississippi State University

  • 8:15 AM. 239. Synthesis of CaCO3 Nanoparticles Using Amino Acids.Bingyun Li, PhD1, Qingyang Li, MS1 1West Virginia University School of Medicine

  • 8:30 AM. 240. Analysis of osteogenic capacity of an octacalcium phosphate bone substitute used in orthopedic bone defect filling.Osamu Suzuki1, Yu Mori2, Ryo Hamai1, Susumu Sakai1, Kaori Tsuchiya1, Toshimi Aizawa2 1Tohoku University Graduate School of Dentistry, 2Tohoku University Graduate School of Medicine

  • 8:45 AM. 241. Bioactive Magnesium Nanocomposites for Bone Repair and Regeneration.Samantha Gmitro1, Andres Larraza1, Pedram Sotoudeh Bagha, Ph.D.1, Mehdi Razavi, Ph.D.1 1University of Central Florida

  • 9:00 AM. 242. Corrosion Characteristics of Electrocautery Damaged (ECD) CoCrMo alloys using Electrochemical Impedance Spectroscopy (EIS).Mohsen Karshenas1, Jeremy Gilbert, Ph.D.1, Charley Goodwin1, Hwaran Lee1 1Clemson University

  • 9:15 AM. 243. Decoupling Interdependent Physical Properties in 3D-Printed Biodegradable Polymer Scaffolds.Sara Oswald1, Andrew Kitson1, Santiago Lazarte2, Brandon Krick, PhD3, Lesley Chow, PhD1 1Lehigh University, 2Florida State University, 3Florida A&M University-Florida State University

  • 9:30 AM. 244. Effects of Galvanic Corrosion on the Cytotoxicity of 3D Printed Magnesium- and Zinc-Based Implants.Jennifer Patterson1, Chloé Lelong2, Alex Duke3, Viktoriia Sevostianova1, Blanca Limones-Ahijón1, Ángela Castro-María1, Carlota Corchado1, Shuai Tang1, Miguel Grande4, Lily Reinke3, Alexander Bakke1, Muzi Li1, Óscar Contreras1, Mahdi Sabbaghian1, Simon Pöstges5, Alexander Kopp5, Javier LLorca1, Jon Molina1 1IMDEA Materials Institute, 2University of Paris-Saclay, 3Michigan State University, 4Imperial College London, 5Meotec GmbH

  • 9:45 AM. 245. Electrical Behavior of Segregated Network Nanocomposites for Orthopedic Applications.Peder Solberg1, Douglas Van Citters, PhD1 1Dartmouth College

5C: Biomaterials for Organoids

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: 4C
Session Type: General Session

Description

Three-dimensional ex vivo organoid cultures using biomaterial-based assembly and self-assembly have been shown to resemble and recapitulate most of the functionality of diverse multicellular tissues and organs, such as the gut, brain, liver, kidney, and lung. They can be dissected and interrogated for fundamental mechanistic studies on human tissue development, regeneration and repair. They can also be used in diagnostics, disease modeling, drug discovery and personalized medicine. For example, in vitro disease models will provide cutting-edge approaches to replicate pathological conditions outside the human body. Thus, organoids bridge a gap in existing model systems by providing a more stable system that is amenable to extended cultivation and manipulation while being more representative of in vivo physiology. This session will cover the most recent advancements in biomaterials-mediated organoid and in vitro models of disease technologies in regenerative medicine, cancer therapy, drug testing, environmental control, monitoring, adaptive sensing, personalized medicine, therapeutic development and translational applications. This topic has been well-received in past SFB meetings and is an exciting emerging research area. In 2025, we will continue this session and promote translational research on the commercial viability of biomaterials-mediated organoid projects.

Moderators:

Qun Wang, Iowa State University
Janeta Zoldan, University of Texas

Objectives

  • 8:00 AM. 198. Developing Chamber-Forming Human Cardiac Organoids in a Synthetic Hydrogel System.Zhen Ma1 1Syracuse University

  • 8:15 AM. 199. Hypoimmunogenic hPSC-derived cardiac organoids evade the host immune response and facilitate cardiac functional recovery.Sophia Silver, BS1, Dimitrios Arhontoulis, PhD2, Nathaniel Hyams, BS1, Mei Li, MD2, Alessandro Howells, BS3, Ryan Barrs, PhD1, Jacelyn Bain, BS1, Charles Kerr, PhD1, Xiaojun Lian, PhD3, Leonardo Ferreira, PhD2, Ying Mei, PhD1 1Clemson University, 2Medical University of South Carolina, 3The Pennsylvania State University

  • 8:30 AM. 200. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis.Austin Graham, PhD1, Michelle Khoo, BS2, Vasudha Srivastava, PhD3, Kavita Parekh, BS4, Ophir Klein, MD, PhD3, Rafael Gómez-Sjöberg, PhD2, Zev Gartner, PhD3 1UCSF & CZBiohub, 2CZBiohub, 3UCSF, 4UC Berkeley

  • 8:45 AM. 201. Enema Transplantation of Interleukin-10 Colonoids for the Treatment of Inflammatory Bowel Disease.Zahra Davoudi, Dr.1, Shadi Parvinroo, Dr.1, Dipak Sahoo, Dr.1, Albert Jergens, Dr.1, Michael Wannemuehler1, Qun Wang, Dr.1 1Iowa State University

  • 9:00 AM. 202. Engineering Human iPSC Derived Planar Neural Organoid (PNO) Models to Study Melanoma Brain Metastases.Joydeb Majumder1, Elizabeth Torr2, William Murphy, PhD3, Apoorva Ramamurthy1, Ulrika Muller1 1University of Wisconsin-Madison, 2University of Wisconsin, 3University of Wisconsin Madison

  • 9:15 AM. 203. FRESH 3D Bioprinting Cell Aggregates with Engineered Architectures.Samuel Moss, B.S.1, Brian Coffin, Ph.D.2, Daniel Shiwarski, Ph.D.2, Adam Feinberg, Ph.D.1 1Carnegie Mellon University, 2University of Pittsburgh

  • 9:30 AM. 204. Innovating Brain Organoid Technology: Enhancing Lymphatic Vascularization with Synthetic Matrices.Dominique Gramm1, Donghyun Jeong1, Brenda Gonzalez1, Christopher Patzke1, Donny Hanjaya-Putra1 1University of Notre Dame

  • 9:45 AM. 205. Optimizing Synthetic PEG-4MAL Hydrogels for the Culture of Patient-Derived Enteroids.Luis Arrieta-Viana1, Tatiana Karakasheva2, Katharine Hamilton3, Andrés García1 1Georgia Institute of Technology, 2Children's Hospital of Philadelphia, 3Children’s Hospital of Philadelphia

5D: Biomaterials-Enhanced Cell Therapy: Beta Cells and Beyond

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: Joliet
Session Type: General Session

Description

This symposium will highlight breakthroughs in biomaterials that enhance the feasibility and translational potential of cell therapies. Biomaterials have been developed to modulate cell behavior, protect cells from immune attacks, guide patient-specific cellular activity, and stimulate endogenous cell recruitment. One key focus area will be biomaterials that augment beta cell replacement for type 1 diabetes, but the session welcomes discussions on a wide range of cell therapy applications.

Moderators:

Edward Phelps, University of Florida
Jessica Weaver, Arizona State University

Objectives

  • 8:30 AM. 207. Vasculogenic, Synthetic Hydrogel Enhances a Marginal Corrective Dose of SC-Islets in the Gonadal Fat Pad of Diabetic Immune Deficient Mice.Sophia Kioulaphides, M.S.1, Angelica Torres, B.S.1, Michael Hunckler, PhD1, Nathaniel Hogrebe, PhD2, Aayush Vaswani1, Graham Barber, B.S.1, Jeffrey Millman, PhD2, Esma Yolcu, PhD3, Haval Shirwan, PhD3, Andrés García1 1Georgia Institute of Technology, 2Washington University St. Louis, 3University of Missouri

  • 8:45 AM. 208. Methacrylic acid-based hydrogel and tuned inflammatory response enable subcutaneous allogeneic islet survival.Sean Kinney, PhD1, Alexander Upenieks, MASc1, Michael Sefton, ScD1 1University of Toronto

  • 9:00 AM. 209. Interrogating the Impact of Porous Scaffold Geometry on Host Responses and Transplant Outcomes In Vivo.Taylor Lansberry, BS1, Robert Accolla, PhD1, Cameron Crouse, BS1, Justin Walsh, BS1, Cherie Stabler, PhD1 1University of Florida

  • 9:15 AM. 210. Anti-TNFα Antisense Oligonucleotide Conjugated PLG Nanoparticles Protect Transplanted Islets.Elizabeth Bealer, MS1, Namit Padgaonkar, BS1, Kelly Crumley, MS1, Eiji Saito, PhD1, Zoe Beekman1, Lonnie Shea1 1University of Michigan

  • 9:30 AM. 211. Development and encapsulation of programable pro-angiogenic cell factories for long-term support of beta cell transplantation.ALVARO MORENO LOZANO1, Martha Fowler1, Shalini Pandey1, Jacob Cabler2, Cassidy Hart1, Michael Gill1, Samantha Fleury1, Yewen Wu3, Qixu Zhang3, Omid Veiseh1 1Rice University, 2Rice Univeristy, 3MD Anderson

  • 9:45 AM. 212. In Vitro Model of the Confined Islet Transplant Site to Evaluate Direct and Indirect T Cell Cytotoxicity and Protective Effects of Islet Biomaterial Encapsulation.Ilaria Pasolini1, Grisell Gonzalez1, Alice Tomei1 1University of Miami

5E: Computational and Machine Learning Approaches for Biomaterial Design & Evaluation

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: 4D
Session Type: General Session

Description

Computational modeling and machine learning can enhance our ability to design and evaluate biomaterials for a variety of applications, and have greatly improved patient care worldwide. This session will explore computational approaches and tools for designing biomaterials for tissue engineering and other applications, evaluating complex data from in vitro and in vivo studies, and predicting biomaterial performance in different microenvironments. Examples of these may include fluid mechanics and bio-transport models of drug/protein delivery, models of protein-protein and protein-material interactions, statistical modeling for biomaterial optimization, machine learning for biomaterial design and analysis, and bioinformatics-based platforms for analyzing complex data, including RNA sequencing and other -omics approaches. Progress and challenges in applying computational approaches in developing biomaterials and in patient care may be discussed.

Moderators:

Adam Gormley, Rutgers University
Bingyun Li, West Virginia University

Objectives

  • 8:00 AM. 213. Automation and Machine Learning for Antibody Formulation in High Concentration Regimes.David Radford, PhD1, Matthew Tamasi, PhD1, Elena Di Mare1, Adam Gormley, PhD1 1Rutgers University

  • 8:15 AM. 214. 3D Multi-Scale Simulations of Electrospun Mesh Mechanical Responses from nanoCT images.Evan He, BS1, Shruti Motiwale, PhD2, Elizabeth Cosgriff-Hernandez, PhD2, Michael sacks, PhD2 1Unversity of Texas at Austin, 2University of Texas at Austin

  • 8:30 AM. 215. Computational Modeling of the Effects of Implant Metallic Composition on the Electrochemical Changes upon Cathodic Stimulation of Total Knee Replacements.Priyanshu Vishnoi, PhD1, Elise Martin, PhD1, Mary Canty, PhD1, Mark Ehrensberger, PhD1 1University at Buffalo

  • 8:45 AM. 216. Data-driven design of novel polymer excipients for pharmaceutical amorphous solid dispersions.Elena Di Mare1, Ashish Punia, PhD2, Matthew Lamm, PhD2, Timothy Rhodes, PhD2, Adam Gormley, PhD1 1Rutgers University, 2Merck & Co., Inc.

  • 9:00 AM. 217. Demonstrating the Impact of L- and D-Peptide Isomer Mixtures on Hydrogel Self-Assembly via Molecular Dynamics.Justin Kim1, Rachel Letteri, PhD1, Phillip Taylor, PhD1, Kyle Lampe, PhD1 1University of Virginia

  • 9:15 AM. 218. 3D pore shape is predictable in randomly packed granular systems.Yasha Saxena1, Lindsay Riley1, Wendy Wu1, Shihab Kabir1, Amanda Randles1, Tatiana Segura, PhD1 1Duke University

  • 9:30 AM. 219. Machine Learning-Based Morphometric and Biomarker Analysis To Guide Elastic Matrix Regenerative Repair in Abdominal Aortic Aneurysms.Francesca Morrell1, Joseph Amitrano2, Anand Ramamurthi, PhD, FAHA2, Dhruv Seshadri2 1Lehigh Univeristy, 2Lehigh University

  • 9:45 AM. 220. Building Predictive Models of Stem Cell Fate from Curvature-Induced Cytoskeletal Changes.Elizabeth Byers1, Justin Brown1 1The Pennsylvania State University

5F: Health Equity SIG: Biomaterials in Women's Health Engineering

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD A
Session Type: General Session

Description

Moderators:

Samantha Zambuto, University of Kentucky
Erika Moore, University of Maryland-College Park

Objectives

  • 8:00 AM. 221. Subcutaneous scaffold implants recapitulate the placental microenvironment for prenatal immunosurveillance.Russell Urie, PhD1, Shannon Dame1, Lauren Hesse1, Elizabeth Lombard1, Chengchuan Xiao1, Lonnie Shea1 1University of Michigan

  • 8:15 AM. 222. Placental Delivery of Cytokine Immunotherapy to Attenuate Diet-Induced Inflammation in Obese Pregnancy.Chloe Catelain, MS1, Harsh Joshi, PhD1, Rana Ajeeb1, Wanke Zhao2, Karen Jonscher, PhD2, John Clegg, PhD1 1University of Oklahoma, 2OUHSC

  • 8:30 AM. 223. Developing a Microporous Annealed Particle Hydrogel to Promote Revascularization of Human Ovarian Tissue.Despina Pavlidis, MS1, Monica Wall, MS1, Chloe Fischer, BS1, Maria Jennings, BS1, Brendon Baker, Ph.D.1, Ariella Shikanov, Ph.D.1 1University of Michigan

  • 8:45 AM. 224. Engineering an ECM Sequestering Fibrous Hydrogel to Promote Ovarian Folliculogenesis.Emily Thomas1, Yuhong Lu1, Riley Sauter1, Claudia Loebel, M.D., Ph.D.1, Brendon Baker, Ph.D.1, Ariella Shikanov, Ph.D.1 1University of Michigan

  • 9:00 AM. 225. Design of Self-fitting Vaginal Stents to Balance Retention and Ease of Removal.Ashley Hicks1, Kailey Wilson1, Varsha Kotamreddy1, Melissa Grunlan, Ph.D.2, Courteney Roberts, B.S.2, Nicholas Grammer3, Julie Hakim, MD4, Elizabeth Cosgriff-Hernandez, PhD3, Taylor Sullivan1 1The University of Texas at Austin, 2Texas A&M University, 3University of Texas at Austin, 4Baylor College of Medicine

  • 9:15 AM. 226. Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta.Hannah Safford1, Cecilia Shuler1, Michael Mitchell, Ph.D.1 1University of Pennsylvania

  • 9:30 AM. 227. Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion and Phenotype.Abbey Nkansah1, Aashee Budwani1,Nicolai Ang1, Nicholas Grammer1, Elizabeth Cosgriff-Hernandez, PhD1, Josephine Allen, PhD2 1University of Texas at Austin, 2University of Florida

  • 9:45 AM. 228. Chemical Characterization of Nanoparticles Shed from Tampons.Jade White1, AnneMarie Hasbrook1, Claire Edwards1, Kaitlin Fogg, Ph.D.1, Joe Baio, Ph.D.1 1Oregon State University

5G: Nanomedicine for Targeted Drug Delivery 1

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: Marquette
Session Type: General Session

Description

This session will emphasize product development and translational nanomedicine, including but not limited to evaluation of product effectiveness in vivo in disease models, nanomedicine manufacturing, and nanomedicine quality control for specific applications. Nanomedicines include colloids and other nanomaterials that have been engineered to target delivery of diverse payloads (such as small molecules, nucleic acids, or biologics) to specific cells or tissues. Targeting approaches may include but are not restricted to cell membrane coating, surface modification, engineering of particle geometry, or engineering other biophysical parameters. Abstracts from academic researchers with translational products or devices are welcomed and abstracts from industry members are especially encouraged.

Moderators:

Gopal Agarwal, University of Florida
Xiao Huang, Drexel University
Marissa Wechsler, University of Texas at San Antonio

Objectives

  • 9:00 AM. 229. Dual-targeting of uPAR and Ribonucleotide Reductase R2 in Triple-Negative Breast Cancer and Stromal Cells for Better Tumor Retention and Enhanced Therapeutic Efficacy.Hsin-Yin Chuang1, Da Huang2, Vidit Singh1, Lin Qi1, Anna Chernatynskaya1, Yue-Wern Huang1, Hu Yang1 1Missouri University of Science and Technology, 2Fuzhou University

  • 8:00 AM. 230. Ligand-targeted polymeric mRNA nanoparticles exhibit T cell tropism for in vivo CAR T cell engineering.Manav Jain1, Savannah Est-Witte1, Sydney Shannon1, Francis Yu1, Jonathan Schneck1, Stephany Tzeng1, Jordan Green, Ph.D.1 1Johns Hopkins University

  • 8:15 AM. 231. Engineering protein-conjugated lipid nanoparticles for targeted, extrahepatic mRNA delivery to the placenta.Hannah Geisler, MS1, Hannah Safford1, Ajay Thatte, MS1, Michael Mitchell, Ph.D.1 1University of Pennsylvania

  • 8:30 AM. 232. Protein Corona Impacts Targeting and Affinity of Layer-by-Layer Nanoparticles.Simone Douglas-Green1, Tamara Dacoba Gomez2, Bhuvna Murthy2, Alfonso Restrepo2, N. Daniel Hills1, Paula Hammond2 1Georgia Tech and Emory University, 2MIT

  • 8:45 AM. 233. Pemetrexed as folate receptor-α (FRα) targeting moiety, active targeting of colorectal cancer using chemotherapy-loaded nanoparticles..Mohammad Alnatour1, Ramkrishna Sen1, Lokesh Janardhanam1, Sean Geary, PhD1, Aliasger Salem, PhD1 1University of Iowa

  • 9:15 AM. 234. In vitro and in vivo development of rat macrophage membrane coated nanoparticles for targeted delivery to inflamed peripheral nerves.Chanpreet Kaur, MD1, Maleen Cabe, MS1, Kelly Langert, PhD1 1Loyola University Chicago

  • 9:30 AM. 235. Ionizable lipid nanoparticles for gene editing of the fetal lung.Adele Ricciardi, MD, PhD1, William Peranteau, MD2, Michael Mitchell, Ph.D.1 1University of Pennsylvania, 2Children's Hospital of Philadelphia

  • 9:45 AM. 236. Targeting nanoparticle delivery to metastatic breast cancer by the intrathecal (cisterna magna) route.Chung-Fan Kuo, PhD1, Elena Andreyko, PhD1, Tobi Babayemi2, Kha Uyen Dam, BS1, Rachael Sirianni, PhD1 1UMass Chan Medical School, 2Rice University

5H: Regenerative Biomaterials for Complex Tissue Regeneration 2

Date: Friday, April 11, 2025
Time: 8:00 AM to 10:00 AM
Room: BLVD C
Session Type: General Session

Description

This symposium will focus on the most recent advances in the design of regenerative biomaterials for engineering challenging tissues and organs. From pancreas to liver and spinal cord, approaches including functional materials, 3D-bioprinting, gene therapy, and nanomaterials, among many others, will be included. We will highlight the recent trends in the development of functional biomaterials that play active role in controlling cellular behavior and complex tissue regeneration. We will cover different classes of biomaterials including the ones that can direct cell fate and promote differentiation. Translational strategies for taking these biomaterials from bench to bedside will also be discussed. Significant international contributions will be selected to facilitate fruitful discussions aiming to progress the advance of the field and to assist the generation of new productive and multidisciplinary collaborations.

Moderators:

Gulden CamciUnal, Univeristy of Massachusetts Lowell
Woojin Han, Icahn School of Medicine at Mount Sinai
Jian Yang, Westlake Univeristy
Guillermo Ameer, Northwestern University

Objectives

  • 9:30 AM. 247. A New Biocomposite Scaffold for Osteochondral Regeneration Utilizing a Gyroid Sheet-based Geometry.Laurel Stefani1, Yashveer Soni1, Robert McLeod, Ph.D.1, Stephanie Bryant, Ph.D.1 1University of Colorado Boulder

  • 8:30 AM. 248. Modular Shape-Controllable Engineered Tissues for Muscle Tissue Engineering.Bugra Ayan, PhD1, Gaoxian Chen, PhD1, Ngan Huang, PhD1 1Stanford University

  • 8:45 AM. 249. Aminated Gel-SH improves gelation kinetics and collagen integration in a tendon-to-bone junction biomaterial.Genesis Rios Adorno, MS1, Kyle Timmer, MS1, Raul Sun Han Chang, Ph.D.1, Jiachun Shi, Ph.D.1, Simon Rogers, Ph.D.1, Brendan Harley, ScD2 1University of Illinois at Urbana Champaign, 2University of Illinois Urbana-Champaign

  • 9:00 AM. 250. Conductive MXene Scaffolds for Composite Musculoskeletal Tissue Regeneration.Emma Kerimo1, Aleyna LaCroix1, Sreejith Panicker, MS2, Anand Tiwari, PhD1, William Scheideler, PhD1, Katherine Hixon, Ph.D.3 1Dartmouth College, 2Washington University St. Louis, 3Dartmouth College, Thayer School of Engineering

  • 9:15 AM. 251. Multiphasic 3D materials with tailored gradients transformed from 2D mats for complex tissue regeneration.Shatil Shahriar1, Jingwei Xie2 1University of Nebraska Medical Center, 2UNMC

  • 9:45 AM. 252. Ulcer-Targeting Prodrug Particles to Promote Regenerative Healing in Inflammatory Bowel Disease.Erika Salzman1, Elaine Tong1, Emma Berman1, Esther Chu1, Phillip Messersmith2 1University of California, Berkeley, 2University of California Berkeley