This session is designed to hear from editors-in-chief of biomaterials journals about ongoing and future initiatives, as well as learn how editorial decisions are made to identify the best forum for your research paper.
Moderator:
Kent Leach, University of California-Davis
Biomaterial surfaces routinely initiate blood coagulation, creating a grand challenge to the development of blood-contacting technologies and the clinical use of cardiovascular devices. Surface designs based on passivation, presentation of bioactive components, or controlled release of anticoagulant and antiplatelet agents are of interest for improving the hemocompatibility of vascular devices for short-term, long-term, and dynamic blood-contacting applications. This symposium will cover the development of new biomaterial design strategies for preventing thrombosis, methods of surface-directed control of cell-surface interactions in the vascular context, in vitro and preclinical models of thrombosis in biomaterials evaluation, as well as fundamental studies of blood-biomaterial interactions.
Moderators:
Hitesh Handa, University of Georgia
Mark Garren, University of Georgia
1:30 PM. 253. In Vitro and In Vivo Assessment of Fluorinated Polyphosphazene Catheter Coatings.Bryan Gregorits1, Yi Wu2, Hitesh Handa2, Chen Chen1, Harry Allcock1, Eric Yeager3, Christopher Siedlecki3, Lichong Xu3 1Penn State University, 2University of Georgia, 3Penn State College of Medicine
1:45 PM. 254. Carboxymethyl kappa-carrageenan: anticoagulant coatings as sustainable alternatives to heparin for blood contacting devices.Liszt Yeltsin Madruga1, Ketul Popat1, Matt J Kipper2, Roberta Sabino3, Somayeh Baghersad2 1George Mason University, 2Colorado State University, 3University of Wyoming
2:00 PM. 255. Cytocompatible and Hemocompatible, Slippery Organogel Coatings Integrated with Bioactive Polymers.Isabel Martinez1, Arpita Shome, PhD1, Myddelton parker2, Yi Wu1 1University of Georgia, 2Universiry of Georgia
2:15 PM. 256. Liquid-Infused (LI) Nitric Oxide (NO) Releasing Submicron-Textured Surfaces for Biocompatibility in Biomedical Devices.Gaurav Pandey1, Asma Khursheed2, Li-Chong Xu, PhD2, Christopher Siedlecki1 1Penn state college of Medicine, 2Pennsylvania State University College of Medicine
2:30 PM. 257. New thermoplastic elastomers for safer, greener and customizable blood-contacting medical devices with antithrombotic profile.Sofia F. Melo1, Anna Pierrard1, Christophe Detrembleur1, Christine Jerome1, Patrizio Lancellotti1, Cecile Oury1 1University of Liege
2:45 PM. 258. Dual surface functionalization of microfluidic blood oxygenators using antithrombin-heparin (ATH) and tissue plasminogen activator (t-PA) for enhanced antithrombotic activity.Siyuan Li1, Neda Saraei1, Helen Atkinson1, Christoph Fusch2, Niels Rochow2, Gerhard Gerhard1, Ravi Selvaganapathy1, John Brash1, Anthony Chan1, Kyla Sask1 1McMaster University, 2University Hospital Nuremberg
3:00 PM. 259. Bioinspired Endothelium-Mimicking Slippery Surface: Long-Term In Vivo Infectious Rabbit Model.Yi Wu1, Patrick Maffe1, Mark Garren1, Aasma Sapkota1, Grace Nguyen1, keren Beita1, Chad Schmiedt, DVM, DACVS1, Elizabeth J. Brisbois1, Hitesh Handa1 1University of Georgia
3:15 PM. 260. Improving the Thromboresistivity of Devices via Surface-Localized Release of Hydrogen Sulfide.Mark Garren1, Rashmi Pandey, PhD1, Morgan Ashcraft, PhD1, Yi Wu1, Dagney Crowley, N/A1, Elizabeth J. Brisbois1, Hitesh Handa1 1University of Georgia
Biomaterial-based cancer models offer a close mimic of the complex tumor microenvironment, providing versatile platforms for screening molecular and cellular therapeutics. Such platforms enable integration of multiple cell populations and matrix compositions, treatment with patient-relevant modalities (e.g. radiation therapies), and detailed mechanistic analysis through high-resolution imaging. This symposium will highlight recent advances in leveraging biomaterial-based cancer models in vitro or in vivo, to accelerate therapeutic delivery with high efficacy and low associated toxicity.
Moderators:
Ricardo Cruz-Acuna, Columbia University
Sara Pedron-Haba, University of Illinois Urbana-Champaign
Silviya Zustiak, Saint Louis University
2:00 PM. 262. Biomaterial-based modeling of radiotherapy outcomes impacts tumor-stroma interactions.Isabella Rivera1, Ryan Yao1, Kimberly Selting, DVM1, Catherine Best-Popescu, PhD1, Brendan Harley, ScD1, Sara Pedron-Haba, PhD1 1University of Illinois Urbana-Champaign
2:15 PM. 263. Microgel Encapsulation of Glioblastoma for an In Vitro Drug Screening Platform.Brittany Payan, B.S.1, Annika Carrillo diaz de leon1, Tejasvi Anand, B.S.1, Gunnar Thompson, B.S.1, Brendan Harley, ScD1 1University of Illinois Urbana-Champaign
2:30 PM. 264. Engineering Dormancy: Insights from a 3D Model of Microscopic Colorectal Cancer Liver Metastasis.Sabrina VandenHeuvel1, Sanjana Roy1, Brinlee Goggans1, Oscar Benavides, PhD1, Alex Walsh, PhD1, Scott Kopetz, MD, PhD2, Shreya Raghavn, PhD1 1Texas A&M University, 2MD Anderson Cancer Center
2:45 PM. 265. A spatially patterned 3D model for assessing drug efficacy in breast cancer-bone metastasis.Vedant Chittake1, Michelle Tai, BS2, Fan Yang, Ph.D.2 1Fan Yang Lab, Stanford University, 2Stanford University
3:00 PM. 266. Embedded Bioprinting of Breast Cancer–Adipose Composite Tissue Model for Patient-Specific Paracrine Interaction Analysis.Wonwoo Jeong, PhD1 1Wake Forest Institute for Regenerative Medicine
3:15 PM. 267. Extracellular matrix cues combine to generate diverse phenotypes during breast cancer progression.Ryan Stowers, Ph.D.1, Abhishek Sharma1, Rowan Steger1, Siddharth Dey, Ph.D.1, Kellie Heom1 1UC Santa Barbara
Extracellular vesicles (EVs) are natural nanoparticles that carry RNA, DNA, proteins, and lipids, and have been given much attention in recent years due to the growing knowledge of their role in driving disease and maintaining health. The objective of this session is to bring together investigators focusing on the characterization and biology of EVs, engineering of EVs, and their utility as diagnostic biomarkers and therapeutics. Example topics include EV nanomaterials science, the interaction of EVs with biological systems, EV biodistribution in vivo and pharmacology, and the utility of EVs for molecular targeting, imaging, diagnostics, immunoengineering, tissue engineering, and drug delivery. EVs from different sources including both mammalian and bacteria-derived EVs will be included.
Moderator:
Eun Ji Chung, University of Southern California
1:30 PM. 268. Silicon nanowires augment therapeutic extracellular vesicle production from human cardiac organoids.Ryan Barrs, PhD1, Nathaniel Hyams, BS2, Mei Li, MD1, Bozhi Tian, PhD3, Ying Mei, PhD2 1Medical University of South Carolina, 2Clemson University, 3University of Chicago
1:45 PM. 269. Piezoelectric nanofibrous scaffold (PES) as a 3D culture platform for enhancing the production of small extracellular vesicles.James Johnston1, Hyunsu Jeon1, Yun Young Choi1, Gaeun Kim1, Tiger Shi1, Courtney Khong1, Hsueh-Chia Chang1, Nosang Myung1, Yichun Wang1 1University of Notre Dame
2:00 PM. 270. Engineered Biomimetic Materials for Enhancing Therapeutic Small Extracellular Vesicles.Yichun Wang1 1University of Notre Dame
2:15 PM. 271. Extracellular Vesicle-incorporated Biostimulatory Matrix Prevents Radiation Dermatitis.Jiayuan Kong1, Kedar Krishnan1, Hexiang Feng1, Kailei Ding1, Sashank Reddy, MD, Ph.D1, Hai-Quan Mao, Ph.D.1 1Johns Hopkins University
2:30 PM. 272. Chiral-Assisted siRNA Loading and pH-Responsive Peptide Functionalization in Small Extracellular Vesicles for Efficient Intracellular Delivery.Gaeun Kim1, Runyao Zhu1, Sihan Yu, PhD1, Bowen Fan1, Jennifer Leon1, Matthew Webber, PhD1, Yichun Wang1 1University of Notre Dame
2:45 PM. 273. Urinary extracellular vesicles as gene and protein delivery devices.
3:00 PM. 274. Engineering Lipid Nanoparticles as a Delivery Vehicle for Novel Extracellular Vesicle-Derived Therapeutics.Lauren Hawthorne1, George Ronan1, Dila Bozkaya1, Jun Yang1, Pinar Zorlutuna1 1University of Notre Dame
3:15 PM. 275. Bioengineering Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries.Breanne Welsh1, Surendrasingh Y Sonaye1, Prabaha Sikder, PhD1 1Cleveland State University
The goal of this session is to exchange ideas involving the unique science and technology present in biomaterials at the nanoscale. Abstracts collectively focused on nanoscale discovery, design, and application are welcome. More specifically, 1) discoveries at the nanoscale and their connection to macroscale properties and behaviors of biomaterials; 2) design and synthesis of nanobiomaterials as relevant for improved devices, diagnostics and therapeutics; and 3) application of nanomaterials to achieve intended biological significance and medical impact. Of particular interest is translational research on nanomaterials effects in the body, including tracking, biodistribution, toxicity, and theranostics. Additional interest lies in the use of multiscale modeling in connecting nanoscale structures and phenomena with macroscale systems in biology and medicine.
Moderators:
Kelly Langert, Loyola University Chicago
Adam Gormley, Rutgers University
1:30 PM. 281. Using Crystallization To Increase Sustainability In The Synthesis Of Poly(Ethylene Glycol) Nanoparticles.Emily Ingram1, Jason Stallings1, Anastasia Shaverina1, Brittany Givens Rassoolkhani, Ph.D1, Malgorzata Chwatko, Ph.D1, Mara Leach1 1University of Kentucky
1:45 PM. 282. Proteins Form Reversible Complexes with Two-Dimensional Nanosilicate Particles.Sam Stealey, PhD1, Jai Rudra, PhD2, Silviya Zustiak, PhD1 1Saint Louis University, 2Washington University in Saint Louis
2:00 PM. 283. Discovery of a Nanospiral Morphology in Self-Assembling Peptide Hydrogels.Paul Eisold1, Jonathan Florian1, Diana Kirilov1, Kyle Lampe, Postdoc, PhD, BS1 1University of Virginia
2:15 PM. 284. Ruthenium-complex Nanomicelle Optical Sensors for High-Resolution Mapping of Oxygen Tension in 3D Tissue-Engineered Tumor Microenvironments.Kevin Schilling, PhD1, Nikita Sehgal, MS1, Carolyn Schutt Ibsen, PhD1 1Oregon Health& Science University
2:30 PM. 285. Core-shell Polymeric Nanoparticles for the Detection and Treatment of Infected Breast Cancer Cells.Spencer Phillips, MS1, Santu Sarkar, Dr.2, Nicole Levi, PhD3, Zach David2 1Wake Forest University, 2Atrium Health Wake Forest Baptist, 3Wake Forest University School of Medicine
2:45 PM. 286. Rationally designed self-immolative and self-deliverable trimeric prodrug nanoassemblies for synergistic combination anticancer therapy.nanhee song, student1, nuri kim, student1, dongwon lee, professor1, changjin lim, professor1, Ilseob kim, student1 1Jeonbuk national university
3:00 PM. 287. Ionizable lipids with reduced numbers of tails direct lipid nanoparticle tropism to the spleen.Kaitlin Mrksich1, Marshall Padilla, PhD1, Emily Han, BS1, Dongyoon Kim, Ph.D.1, Michael Mitchell, Ph.D.1 1University of Pennsylvania
3:15 PM. 288. Parameters of emulsion polymerization and copolymer composition predict nanoparticle properties and lymphatic uptake.Alexander Heiler1, Tae Hee Yoon1, Maya Levitan1, Yunus Alapan, PhD2, Susan Thomas, PhD1 1Georgia Institute of Technology, 2University of Wisconsin - Madison
The Biomaterials and Medical Products Commercialization SIG aims to provide researchers with the necessary tools to take their ideas from concept to physical product to market-ready technology. This session will focus on highlighting the various considerations needed on a product's journey to commercialization including, but not limited to, sterilization and purification, product scale-up and robust manufacturing, product purification, quality control, regulatory considerations, reimbursement strategies, supply chain, and market adoption. Examples will be provided from members of academia and industry, from small start-ups to large organizations, and from numerous markets and end-use applications. This session will hopefully inform and inspire the SFB community as they start and/or continue down the path of product development and commercialization.
Moderators:
Stephanie Steichen, The University of Texas at Austin
Brittany Givens Rassoolkhani, University of Kentucky
Scott Taylor, Poly-Med
Lauren Costella, Luna Labs
Brian Kwee, University of Delaware
1:30 PM. Development of a microneedle patch for self-administered, long-acting contraception. Mark Prausnitz. Georgia Institute of Technology
2:00 PM. 290. Development of the Secure Polymeric Tissue Tag (SPOTT) breast biopsy device.Juan Llull, BS1, Nicole Levi, PhD2, Darnell Campbell, B.S.2, Clifford Howard, MD1, Jordan Forte, MD1 1Atrium Health Wake Forest Baptist, 2Wake Forest University School of Medicine
2:15 PM. 291. Scalability of Electrospun Polycaprolactone for Medical Devices: Overcoming Challenges for Commercialization.Hannah Lacy1, Francisco Chaparro1, R. Kevin Tindell2 1Nanoscience Instruments, 2Nanoscience Analytical
2:30 PM. 292. Regulatory Validation and Commercialization of a Sprayable Hydrogel for Postoperative Adhesion Prevention.Lauren Costella, Principal Scientist1, Kate Johnson1, Christopher Tison, PhD1 1Luna Labs USA
2:45 PM. 293. From Concept to Care: Successfully Designing Durability into Product Commercialization.Ann Gronda, Ph.D.1 1Medtronic
3:00 PM. 294. Advanced Dry Gel Medical Device for Effective Prehospital Management of Junctional Hemorrhage.Shatil Shahriar1, Jingwei Xie2 1University of Nebraska Medical Center, 2UNMC
3:15 PM. 295. Green Lunar: Turning Waste into Wealth with Dual-Function Halloysite Nanotubes for Lunar Agriculture and Medical Applications.Zeinab Jabbari Velisdeh, Ph.D Candidate1, David K Mills1 1College of Engineering and Science, Louisiana Tech University, Ruston, USA.
Materials that respond to environmental stimuli, such as heat, light, pH, or biological signals, provide unique tools for environmentally-responsive and/or temporal changes in biomaterial properties over time. This session will focus on materials, including hybrid materials, that can be stimulated with a variety of physiological and external stimuli to achieve desired outcomes. Research related to the use of stimuli-responsive materials that respond to endogenous or exogenous signals to (1) trigger drug delivery, (2) study and control the cellular response to microenvironmental changes, and/or (3) drive tissue regeneration and disease treatment is of particular interest.
Moderators:
Carolyn Schutt-Ibsen, OHSU
Claudia Loebel, University of Michigan
Brendon Baker, University of Michigan
1:30 PM. 296. Digital Light Processing of Photo-Responsive and Programmable Hydrogels.Abhishek Dhand1, Bruce Kirkpatrick2, Manuela Garay-Sarmiento3, Kristi Anseth2, Jason Burdick3 1University of Pennsylvania, 2University of Colorado Boulder, 3University of Colorado, Boulder
1:45 PM. 297. Dynamic Gelatin Hydrogels Crosslinked by Dithiolane-Norbornene Click Chemistry.Favour Afolabi1, Lydia He1, Chien-Chi Lin, Ph.D.1 1Purdue University
2:00 PM. 298. Multi-domain disordered proteins enable highly programmable self-assembly of intracellular biomaterial-condensates.Ian Sicher, M.Eng.1, Spencer Hayes2, Maria Giraldo-Castano, B.S.3, Keerthy Rangan3, Mariell Pascual, B.S.3, Felipe Quiroz, Ph.D3 1Georgia Institute of Technology, 2Emopry University, 3Emory University
2:15 PM. 299. Magnetoactive hydrogels to mimic arterial wall buckling in atherosclerosis.Claudia Loebel, M.D., Ph.D.1, Avinava Roy, M.S.E1 1University of Michigan
2:30 PM. 300. Boolean Logic-gated Protein Release via Autonomously Compiled Molecular Topology.Murial Ross1, Ryan Gharios, PhD1, Annabella Li1, Shivani Kottantharayil1, Jack Hoye1, Cole DeForest, PhD1 1University of Washington
2:45 PM. 301. Light-responsive Core-Shell Microparticles for Chemo-Photothermal Triple-Negative Breast Cancer Therapy.Tom Buckman1, Vanessa Uzonwanne1, Maria Onyekanne1, Nava Bozorgmehri1, Jordan Paul1, Suhani Gupta1, Ali Salifu1 1Boston College
3:00 PM. 302. Engineering Focused Ultrasound-Responsive Granular Hydrogels for Microvasculature.Natasha Claxton1, Matthew DeWitt, PhD2, Richard Price, PhD1, Kelly Bukovic1, Rachel Letteri, PhD1, Steven Caliari, PhD1, Andrew Thim, PhD1, Christopher Highley, PhD1 1University of Virginia, 2University of Virginia/Focused Ultrasound Cancer Immunotherapy Center
3:15 PM. 303. Mechanical-Driven Sarcomere Disarray of BAG3-mutated Human iPSC-Derived Cardiomyocytes on a Dynamic Topographic Substrate.Nhu Y Mai1, Xiangjun Wu1, James Henderson1, Zhen Ma1 1Syracuse University
In this invited speaker symposium honoring Shelly Sakiyama-Elbert on her 50th Birthday, we will celebrate 25 Years of of her impact shaping biomaterials in neuroengineering.
Moderator:
Elizabeth Cosgriff-Hernandez, The University of Texas at Austin
1:30 PM. 1. Stephanie Willerth
1:45 PM. 2. Evan Scott
2:00 PM. 3. Nisha Iyer
2:15 PM. 4. Sarah Stabenfeldt
2:30 PM. 5. Tatiana Segura
2:45 PM. 6. Molly Shoichet
3:00 PM. 7. Jeff Hubbell