8A: PANEL: Insights & Perspectives from NSF/NIBIB Next Generation Biomaterials

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: BLVD C
Session Type: General Session

Description

The Knight Campus for Accelerating Scientific Impact at the University of Oregon hosted an NSF and NIH-funded workshop to bring together >40 thought leaders from industry, academia, national labs, and scientific publishing to discuss major gaps and opportunities in converting advancing in biomaterials science to impactful biomedical applications. The workshop focused on four integrated “science drivers” critical to the development and translation of next generation biomaterials: (1) synthetic biology-enabled biomaterials, (2) smart/responsive biomaterials, (3) biofabrication and biointerfaces, and (4) data-driven methods for biomaterials design. This session will summarize and share insights and perspectives from this workshop and invite panelists from NSF, NIH, FDA, NIST, and industry to reflect on and share their own thoughts on the workshop outcomes. The perspectives shared in this session will be of significant interest to clinicians, academic researchers, and industry.

Moderator:

Daniell Benoit, University of Oregon
Matthew Webber, University of Notre Dame

Speakers

8B: Bioelectronics & Wearable Sensors

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: 4C
Session Type: General Session

Description

Rapid advancements in soft bioelectronics and wearable sensors promise to revolutionize various fields ranging from fundamental biological research and clinical healthcare to fitness tracking and human-machine interfaces, while also enabling a shift from hospital-based to patient-centered care. This symposium will serve as a dynamic platform for academic researchers, funding agencies, and industry leaders to exchange insights on the latest advancements in soft bioelectronics and their customized applications. The scope of the symposium is broad, including but not limited to novel biomaterials and bioelectronics designs to enhance device performance, innovative manufacturing approaches, conductive scaffolds for tissue regeneration, integration of biosensors with wearable systems, machine learning and artificial intelligence for data analysis, disease diagnostics and automatic decision making, customization for specific healthcare applications, challenges and future directions of soft bioelectronics and wearable sensors, and others. This forum will foster collaboration and innovation, paving the way for next-generation, personalized healthcare technologies.

Moderators:

Zheng Yan, University of Missouri
Cunjiang Yu, University of Illinois
Murat Guvendiren, New Jersey Institute of Technology

Invited Speaker Presentations

Dr. John Rogers
Talk Title: Enabling Materials in Soft and Transient Systems for Closed-Loop Electrotherapy

Dr. Bozhi Tian
Talk Title: Exploring Bioelectronics Through the Lens of Energy Science

Objectives

  • 9:00 AM. 376. Biodegradable Piezoelectric Nanofibers for Medical Applications.Jinyoung Park, Master's degree1, Thinh Le, Doctoral degree1, Meysam Chorsi, Doctoral degree1, Thanh Nguyen, PhD1 1University of Connecticut

  • 9:15 AM. 377. Hydrogel Electrodes for Real-Time Tumor Sensing and Extracellular Matrix Response.Aydasadat Pourmostafa, PhD scholar1, Anant Bhusal, postdoctoral scholar2, Niranjan Menon, PhD scholar3, Amir K Miri, Dr Faculty1, sagnik basuray, faculty1 1New Jersey Institute of Technology, 2Rowan university, 3newjersy institute of technology

  • 9:30 AM. 378. Electrochemical Sensing of Endogenous Nitric Oxide as a Function of Diabetes.Mikaylin Nogler1, Mark Schoenfisch2 1The University of North Carolina at Chapel Hill, 2UNC Chapel Hill

  • 9:45 AM. 379. Development of an Electrogenetic Cell-Based Therapy for On-Demand Cytokine Delivery.Grace May1, Rachel Daso1, Victoria Kindratenko2, Ellie Chen1, Samantha Fleury1, Amaury Bittar1, Matthew Parker1, Christian Schreib, PhD1, Isaac Hilton, PhD1, Laura Segatori, PhD1, Jacob Robinson, PhD1, Jonathan Rivnay, PhD2, Omid Veiseh, PhD1 1Rice University, 2Northwestern University

Speakers

8C: Engineering Cells and Their Microenvironments SIG 2

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: BLVD A
Session Type: General Session

Description

The Engineering Cells & Their Microenvironments Special Interest Group focuses on technologies and approaches at the single-cell level and the engineering of cellular microenvironments. This includes designing dynamic cues within biomaterials to regulate cell signaling and stem cell fate, as well as advancing stem cell manufacturing and differentiation, immunoengineering, and biomaterials for cell-based detection and diagnosis.

Moderators:

Janeta Zoldan, University of Texas
Kyle Lampe, University of Virginia
Silviya Zustiak, Saint Louis University

Objectives

  • 10:30 AM. 386. Development of a Gelatin-based Hypoxic Perivascular Niche to Model the Bone Marrow.Gunnar Thompson, B.S.1, Victoria Barnhouse, PhD1, Sydney Bierman, B.S.1, Brendan Harley, ScD1, Kristopher Kilian, PhD2 1University of Illinois Urbana-Champaign, 2University of New South Wales

  • 10:45 AM. 387. Hydrogel Facilitated Immune-Cancer Cell Co-culture Tumor Microenvironments.Vanshika Singh, PhD1, Muhammad Raisul Abedin2, Jordan Yaron, PhD1, Kaushal Rege, PhD1, Trishita Chowdhury1 1Arizona State University, 2Adipo Therapeutics

  • 11:00 AM. 388. Hydrogels with both dynamic and static RGD have increased adhesion formation and cell spreading.Abolfazl Moghaddam, MS1, E. Thomas Pashuck, PhD1 1Lehigh University

  • 11:15 AM. 389. Magnetic control of biomimetic multiscale ligand dynamics for stem cell regulation.Sunhong Min1, Heemin Kang1 1Korea University

  • 11:30 AM. 390. Modulating 4D Cell Function via Grayscale Spatiotemporal Biomaterial Customization.Ryan Brady1, Ryan Francis1, Jeremy Filteau, PhD1, Irina Kopyeva, PhD1, Cole DeForest, PhD1 1University of Washington

  • 11:45 AM. 391. Synthetic Regulation of Cell Signaling within Engineered Microenvironments to Control Vascularization.Mai Ngo, PhD1 1University of Wisconsin-Madison

  • 12:00 PM. 392. Tri-Directional Interactions between Cells, Hydrogels, and Nascent ECM Govern Cell Fate.Yu-Chung (Joshua) Liu, M.S.1, Eleanor Plaster1, Avinava Roy, M.S.E1, Matthew Tan, Ph.D.1, Pamela Duran, PhD1, Gabriel Walters, BS1, Carlos Aguilar, PhD1, Claudia Loebel, M.D., Ph.D.1 1University of Michigan

  • 12:15 PM. 393. Tuning hydrogel cell scaffolds by varying secondary structure of peptoid crosslinkers.Aldaly Pineda-Hernandez1, David Castilla-Casadiego, PhD1, Logan Morton, PhD2, Adrianne Rosales, PhD3 1The University of Texas at Austin, 2Tufts University, 3University of Texas at Austin

8D: Granular & Macroporous Biomaterials for Tissue Engineering 2

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: 4D
Session Type: General Session

Description

Granular hydrogel materials emerged as a class of biomaterial that provide for well-defined in vitro and in vivo systems with plug-and-play components and tissue-mimicking 3D environments. Granular hydrogels are composed of a slurry of microgel particles that are assembled to form a larger porous structure. Microporous annealed particle (MAP) scaffolds are a subclass of granular hydrogel material with a void space network stabilized by inter-particle chemical bonds. The modular nature of granular hydrogels offers enormous tunability in not only the individual microgel design but also the homogenous or heterogenous microgel assembly into the bulk scaffold. This session will explore current advances in granular hydrogel technology, including MAP scaffolds, for both immune modulation, tissue repair, organ-on-a-chip, and 3D-printing applications

Moderators:

Donald Griffin, University of Virginia
Tatiana Segura, Duke University

Objectives

  • 10:30 AM. 394. MAP scaffolds modulate collagen fibril formation and fibroblast phenotype.Alejandra Suarez Arnedo1, Michaela Harris1, Ari Willig1, Brenton D Hoffman1, Tatiana Segura, PhD1 1Duke University

  • 11:00 AM. 395. A Novel PEG-Based Injectable Macroporous Hydrogel Scaffold.Mary Dickenson, MSE1, Sydney Wheeler, MSE1, Kiera Downey, MSE1, Weiping Li, PhD1, Jan Stegemann, PhD1, Cheri Deng, PhD1, Aaron Morris, PhD1 1University of Michigan

  • 10:45 AM. 396. Investigating the Impact of Biomaterial Chirality on Host-material Interaction Using a Limited Lymphocyte Egress Model.Eleanor L.P. Caston1, Yongjae Lee1, Pablo Cordero Alvarado1, Michelle Schneider, MD/PhD1, Tatiana Segura, PhD1 1Duke University

  • 11:15 AM. 397. Alginate granular scaffolds support formation of hypertrophic and chondrogenic constructs made from ECM-loaded MSC spheroids.David H Ramos-Rodriguez1, Andrea C Filler1, J. Kent Leach1 1UC Davis Health

  • 11:30 AM. 398. Development of Avidity-Controlled Biotherapeutic Delivery Systems for the Treatment of Acute Kidney Injury.Arielle D'Elia, MS1, Kenneth Kim, MS2, Carl Russell III, BS3, Akari Seiner, MS1, Alex Osidach, M.S.1, Winni Gao, BS1, Danielle Soranno, MD3, Christopher Rodell, Ph.D.1 1Drexel University, 2Drexel University College of Medicine, 3Indiana University

  • 11:45 AM. 399. Granular Hydrogel Composites for Microvascularized Engineered Tissue Grafts.Michael Hu, MS1, Gonzalo Anyosa-Galvez1, Firaol Midekssa, MS1, Brendon Baker, Ph.D.1 1University of Michigan

  • Santiago Orrego, Temple University

  • 12:00 PM. 400. Multicellular Granular Hydrogels of the Perivascular Niche to Study Glioblastoma Progression.Brittany Payan, B.S.1, Tejasvi Anand, B.S.1, Joel Kattoor1, Brendan Harley, ScD1 1University of Illinois Urbana-Champaign

  • 12:15 PM. 401. Programmed Shape Transformations in Cell-laden Granular Hydrogel Composites.Nikolas Di Caprio1, Alex Hughes, PhD2, Jason Burdick3 1University of Pennslyvania, 2University of Pennsylvania, 3University of Colorado, Boulder

8E: Immune Engineering SIG 2

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: Joliet
Session Type: General Session

Description

Over the past decade the focus of many bioengineers and clinicians has been shifting towards "immune engineering" approaches that include but are not limited to engineered biomaterials for vaccines, immunotherapy (immune-modulation), cell and gene therapy, immune microenvironment engineering, and systems immunology. These research areas embrace a comprehensive list of translational immunology-associated problems including chronic infections, autoimmune diseases, aggressive cancers, allergies, etc. The purpose of the Immune Engineering SIG is to bring together emerging ideas and provide a venue for professional interaction to a large number of academic and industrial research groups and scientists working in these areas.

Moderators:

Josh Doloff, Johns Hopkins Whiting School of Engineering

Objectives

  • 10:30 AM. 402. Comparative Analysis of Tonsil Versus PBMC-derived Human Immune Organoids in Long-term Immune Response to Vaccines and Adjuvants.Zhe Zhong1, Andrés García1, JEAN KOFF, MD, MS2, Ankur Singh, Ph.D.1 1Georgia Institute of Technology, 2Emory University School of Medicine

  • 10:45 AM. 403. Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms.Michael Monaghan, B.Eng, PhD1 1Trinity College Dublin

  • 11:00 AM. 404. The aged bone marrow and the onset of hematopoietic stem cell aging in a polyisocyanopeptide hydrogel.Aidan Gilchrist, PhD1 1University of California, Davis

  • 11:15 AM. 405. Immune Organ-on-Chip Reveal Dysregulated Zonal Compartmentalization in Cancer Patients.Zhe Zhong1, Manuel Quiñones Pérez1, Andrés García1, JEAN KOFF, MD, MS2, Ankur Singh, Ph.D.1 1Georgia Institute of Technology, 2Emory University School of Medicine

  • 11:30 AM. 406. Localized Delivery of Encapsulated Cell Therapy for Targeted Modulation in Pulmonary Fibrosis.Kailyn Nunesz1, Samira Aghlara-Fotovat2, Miguel Mendez3, Ravi Ghanta3, Omid Veiseh1 1Rice University, 2Sentinel Biotherapeutics, 3Baylor College of Medicine

  • 11:45 AM. 407. Anatomical location and alloy/surface treatment composition-specific immune responses to metallic implants.Stuart Bauer, B.S., M.S.1, Jessica Stelzel, B.S.1, Valerie Wong1, Allison Horenberg, B.S.1, Peter Kurtz, 2, Jeremy L. Gilbert, 2, Warren Grayson, Ph.D.1, Joshua Doloff, Ph.D.1 1Johns Hopkins University 2 Clemson University

  • 12:00 PM. 408. Glycation of collagen affects osteogenic differentiation of hMSCs and intrafibrillar mineralization.Siyoung Choi1, Lara Estroff1, Claudia Fischbach1 1Cornell University

  • 12:15 PM. 409. Matrix Mechanics Influences Microvascular Senescence and Pro-inflammation.Jiyeon Song, PhD1, Ya Guan1, Connor Amelung1, Sharon Gerecht, PhD1 1Duke University

8F: BioInterfaces SIG

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: BLVD B
Session Type: General Session

Description

The junction between materials and biological systems is a critical and complex interface with the potential to control the function of macromolecules and dictate cell and tissue responses. Increasingly, cells and biomacromolecules are designable components of biomaterials, creating additional opportunities for innovative research at the interface of materials science and fundamental biology. This session serves as a forum for advances in approaches to modulate interfacial properties, investigations of structure-function and self-assembly at biointerfaces, and applications of interface-driven biomedicine. Specific areas of interest include fundamental research related to dynamic interactions at the material-biomolecular interface from nano to bulk scales and applied research focused on providing hemocompatible and non-fouling biomaterial surfaces. We also encourage contributions that advance a biomaterials lens to cutting-edge research in protein and cell biology, and research that translates progress in molecular and cell biology into innovative biomaterials.

Moderators:

Nathan Gallant, University of South Florida
MaryBeth Monroe, Syracuse Univeristy

Objectives

  • 11:30 AM. 382. Vocal Fold Functional Recovery after Intubation Trauma Treated with Composite-Coated Endotracheal Tubes.Gabriela Cervantes-Gonzales1, Ronit Malka2, Joo Ong1, Rena Bizios1, Greogry Dion3, Teja Guda1 1The University of Texas at San Antonio, 2Brooke Army Medical Center, 3University of Cincinnati Medical Center

  • 11:45 AM. 383. Biodegradable Polyurethane Foams with Enhanced Bioactivity to Improve Traumatic Wound Healing.Natalie Petryk, MS1, Leo Saldanha1, Shawn Sutherland1, Mary Beth Monroe, PhD1 1Syracuse University

  • 12:00 PM. 384. Engineering Dynamic Topographies to Modulate Biological Interactions.Jouha Min1 1University of Michigan

  • 12:15 PM. 385. Hydrogel Viscoelasticity Regulates Cellular Adhesion to Nascent Matrix.Matthew Tan, Ph.D.1, Eleanor Plaster1, Haguy Wolfenson, Ph.D.2, Claudia Loebel, M.D., Ph.D.1 1University of Michigan, 2Technion - Israel Institute of Technology

8G: Tissue Engineering SIG 3

Date: Saturday, April 12, 2025
Time: 10:30 AM to 12:30 PM
Room: 4A
Session Type: General Session

Description

Tissue Engineering SIG is a forum to exchange information, further knowledge, and promote greater awareness regarding all aspects of the use of biomaterials to engineering tissue substitutes or to promote tissue regeneration. Of primary interest and relevance to TE SIG is the use of appropriate materials (synthetic and natural) with cells (either native or from a donor source) and/or biological response modifiers (e.g., growth factors, cytokines and other recombinant products) to replace tissue and organ functions. Particular emphasis is placed on the development of materials to better incorporate, protect, and deliver both the cells and biological response modifiers to help promote the healing and regenerative processes. The group is committed to forging interactions among basic scientists, applied scientists, engineers, clinicians, industrial members, professional societies in related fields, and regulatory groups in its efforts to expand and effectively utilize the shared knowledge base in this multidisciplinary field.

Moderators:

Woojin Han, Icahn School of Medicine at Mount Sinai
Qun Wang, Iowa State University

Objectives

  • 10:30 AM. 411. Exercise-induced piezoelectric stimulation for cartilage regeneration in large animal model.Nidhi Sharma, nis220121, Yang Liu1, Thanh Nguyen, PhD1 1University of Connecticut

  • 10:45 AM. 412. Sustained Local Delivery of Butyrate for Enhanced Muscle Regeneration in Ischemic Limbs.Nikita John1, Calvin Chao, M.D.2, Caitlyn Dang3, Bin Jiang, Ph.D.1 1Northwestern University, 2Feinberg School of Medicine, Northwestern University, 3Feingberg School of Medicine, Northwestern University

  • 11:00 AM. 413. A Viscoelastic Tissue-Mimetic Hydrogel for Modelling Chondrogenesis.Elizabeth George1, Stephanie Bryant, Ph.D.1 1University of Colorado Boulder

  • 11:15 AM. 414. Microparticles with Tunable Aspect Ratios Using Photolithography for Injectable Granular Hydrogel Formation and Cell Delivery.Jun Kim, PhD1, Dean Stornello1, Taimoor Qazi, PhD1 1Purdue University

  • 11:30 AM. 415. Patterning fiber types in engineered muscle tissues with optogenetics.Ronald Heisser, PhD1, Angel Bu1, Tamara Rossy, PhD1, Ritu Raman1 1MIT

  • 11:45 AM. 416. Covalent Tethering of Immunomodulatory Cytokines into Poly(ethylene glycol) thiol-norbornene Hydrogels.laurel Stefani1, Stephanie Bryant, Ph.D.1, Kayla Castillo-Aguilar1 1University of Colorado Boulder

  • 12:00 PM. 417. Determining Matrix Contributions Leading to Dysfunction in Adipocytes.Sameera Vellore1, Qinghua Xu1, Marisa Egan2, Paulina Babiak1, Julie Liu, PhD2, Luis Solorio, PhD1 1Purdue University West Lafayette, 2Purdue University

  • 12:15 PM. 418. Stronger by Nature: Advancing Biomaterials with Functional Nanoparticle-Enhanced Silk Hydrogels.Olivia Foster, B.S.1, Derek Hiscox, B.S1, Sawnaz Shaidani, B.S.1, Riley Patten, B.S.1, Ella Canas1, Jean Park1, Charlotte Jacobus, B.S.1, David Kaplan, PhD1 1Tufts University