Benchtop Models to Support Medical Device and Pharmaceutical Invention and Commercialization

4:15 p.m. 59. Invited Speaker: The Next Dimension: Transitioning Drug Screening Assays to #D to Improve Toxicity Predictions, David Grainger, University of Utah

4:45 p.m. 60. Degradation of PLLA Tubes in a Pulsatile Flow Loop as a Model for Cardiovascular Stent Degradation, M. L. Dreher*(1), S. Nagaraja(1), Q. Lu(1), R. Malinauskas(1), B. Batchelor(2), (1)FDA/CDRH, SIlver Spring, MD, (2)University of Texas at Dallas, Richardson, TX

5:00 p.m. 61. Effects of Fatigue Loading on Absorbable Stent Sub-Unit Degradation, M. L. Dreher*(1), S. Nagaraja(1), B. Batchelor(2), (1)FDA/CDRH, Silver Spring, MD, (2)University of Texas at Dallas, Richardson, TX

5:15 p.m. 62. Ventilator-Endotracheal Tube-Lung Benchtop Model for Luminal Occlusion, C. M. Magin*(1), R. M. May(1), M. R. Mettetal(1), A. Potthoff(1), M. D. Twite(2), S. T. Reddy(1), (1)Sharklet Technologies, Inc., Aurora, CO, (2)Children's Hospital, Aurora, CO

5:30 p.m. 63. Development of a High-Throughput Ultrasound Technique for the Analysis of Tissue Engineering Constructs, M. Goss*(1), J. Stukel(2), R. Willits(2), A. Exner(1), (1)Case Western Reserve University, Cleveland, OH, (2)The University of Akron, Akron, OH

5:45 p.m. 64. Bench-Top Assay of Inflammation with Human Macrophages on Biomaterials, C. E. Witherel*, K. L. Spiller, Drexel University, Philadelphia, PA

6:00 p.m. 65. Platelet and Leukocyte Counts as Hemocompatibility Indicators for Biomaterials: An Evaluation of ASTM Standard Test Method F2888-13, Q. Lu*, J. M. Nehrer, R. Malinauskas, U.S. Food and Drug Administration, Silver Spring, MD

Characterization of Microenvironment of Immune Cells in Wound Healing

4:15 p.m. 66. Affinity-based Controlled Release Scaffolds for Modulation of Macrophage Phenotype in Chronic Diabetic Ulcers, S. Nassiri*, K. L. Spiller, Drexel University, Philadelphia, PA

4:30 p.m. 67. Microstructural and Functional Analysis of Polymeric Composite Materials for Near Infrared Imaging, A. Stevenson, Jr.*(1), L. Reese(1), T. Hill(2), J. McGuire(1), A. Mohs(2), R. Shekhar(3), L. Bickford(1), A. Whittington(1), (1)Virginia Tech, Blacksburg, VA, (2)Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, (3)The Children's National Medical Center, Washington, DC

4:45 p.m. 68. Chemical Imaging of the Breast Tumor Microenvironment, L. Gamble*(1), B. Bluestein(1), D. Graham(1), F. Morrish(2), D. Hockenbery(2), P. Porter(2), (1)University of Washington, Seattle, WA, (2)Fred Hutchinson Cancer Research Center, Seattle, WA

5:00 p.m. 69. Effects of Adhesive Cues on Macrophage Cytokine Secretion: a Single Cell Analysis, F. Y. McWhorter*, T. D. Smith, T. Chung, W. F. Liu, UC Irvine, Irvine, CA

5:15 p.m. 70. Mechanically- & Biologically-Tunable Polyethylene Glycol Hydrogels for Quantitative Neutrophil Migration Assays, B. J. Walker*, A. L. Gonzalez, Yale University, New Haven, CT

5:30 p.m. 71. Study the Effect of Electrical Stimulation Through the Conductive Membranes on the Wound Healing Gene Expression in Normal Human Dermal Fibroblasts, H. Park*(1), M. R. Rouabhia(2), D. L. Lavertu(3), Z. Zhang*(3), (1)Laval university, Centre de recherche du CHU de Qubec, Qubec, QC, Canada, (2)Laval University, Qubec, QC, Canada, (3)Centre de recherche du CHU de Qubec, Qubec, QC, Canada

5:45 p.m. 72. Investigating the Migratory Behavior of Macrophage Subtypes, J. Y. Hsieh*, T. Smith, W. F. Liu, University of California, Irvine, Irvine, CA

6:00 p.m. 73. The Response of Progenitor Cells and Macrophages on a Bone Substitute to Biologically Relevant pH Levels, O. Horton*(1), W. Bridges, Jr.(1), K. Burg(2), (1)Clemson University, Clemson, SC, (2)Kansas State University, Manhattan, KS

Drug Delivery for Immunomodulation

4:15 p.m. 74. Molecular Dissemination into Local and Systemic Tissues is Regulated by Molecular Size and Tumor Vascular Status: Implications for Targeted Drug Delivery in Cancer Immunotherapy, N. Rohner*, S. N. Thomas, Georgia Institute of Technology, Atlanta, GA

4:30 p.m. 75. Dextran Coated Cerium Oxide Nanoparticles Act as Antioxidants, E. Alpaslan*(1), M. Vargas(2), A. K. Roy(1), T. J. Webster(1), (1)Northeastern University, Boston, MA, (2)University of Antioquia, Medelln, Colombia

4:45 p.m. 76. On-demand Immunomodulation Centers for Reducing Inflammation in Osteoarthritis, Y. F. Tian*, R. S. Schneider, D. Holyoak, M. C. H. van der Meulen, A. Singh, Cornell University, Ithaca, NY

5:00 p.m. 77. S-Nitrosated Poly(Propylene Sulfide) Nanoparticles Exhibit Thiol-Dependent Transnitrosation and Toxicity Against Adult Female B. Malayi Filarial Worms, A. Schudel*, T. Kassis, J. B. Dixon, S. N. Thomas, Georgia Institute of Technology, Atlanta, GA

5:15 p.m. 78. Nanoparticle Mediated Delivery of Glutamate Enhancers to Restrain Autoimmune Reactions, J. M. Gammon*, L. H. Tostanoski, Y. Chiu, C. M. Jewell, University of Maryland - College Park, College Park, MD

5:30 p.m. 79. Development of a Cytokine-Loaded Layer by Layer Coating on Polypropylene Meshes to Modulate Macrophage Polarization at the Tissue-Implant Interface, D. Hachim*, S. T. LoPresti, B. N. Brown, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA

5:45 p.m. 80. Polymersome-Templated Porous and Hollow Nanogels for Dual Intracellular Delivery, F. Du*, E. A. Scott*, Northwestern University, Evanston, IL

6:00 p.m. 81. Modulation of the Immune Response via the NF-Kb Signaling Pathway in Rheumatoid Arthritis in vitro Models, P. R. Wardwell*, R. A. Bader, Syracuse University, Syracuse, NY

Macromolecular Drug Delivery

4:15 p.m. 82. Inhalable Dry Powder Microparticles for Delivery of Bacteriophages to Treat Cystic Fibrosis Associated Bacterial Lung Infections, R. Agarwal*, C. Johnson, A. J. Garcia, Georgia Institute of Technology, Atlanta, GA

4:30 p.m. 83. Intracellular Trafficking of Alginate-graft-Poly (Ethylene Glycol) Microspheres for Promoting Mesenchymal Stem Cell Osteogenic Differentiation, T. Miao*, R. A. Oldinski, University of Vermont, Burlington, VT

4:45 p.m. 84. Cholera Toxin Subunit B-Modified Mesoporous Silica Nanoparticles as Vehicles for the Improved Intracellular Delivery of Proteins, W. A. Walker*(1), J. L. Vivero-Escoto(2), (1)University of North Carolina-Charlotte, Waxhaw, NC, (2)University of North Carolina-Charlotte, Charlotte, NC

5:00 p.m. 85. Reactive Oxygen Species (ROS)-responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy, Q. Xu*, M. Wang, Tufts University, Medford, MA

5:15 p.m. 86. Bioorthogonal Hyaluronate Hydrogels for Therapeutic Protein Delivery, A. Famili*, J. G. Aaronson, K. Rajagopal, Genentech Inc., South San Francisco, CA

5:30 p.m. 87. Self-Assembled Tannin Complexes for Redox Responsive Drug Delivery, H. A. Cheng*(1), C. T. Drinnan(1), E. Yoo(2), A. L. Doiron(2), O. Z. Fisher(1), (1)Temple University, Philadelphia, PA, (2)Binghamton University, SUNY, Binghamton, NY

5:45 p.m. 88. Controlled Local Delivery of Therapeutic Antibodies from Injectable Hydrogels, N. A. Fletcher*, M. D. Krebs, Colorado School of Mines, Golden, CO

6:00 p.m. 89. pH-Responsive Polymeric Vehicles for the Oral Delivery of Hemophiliac Factor IX, S. D. Horava*, N. A. Peppas, The University of Texas at Austin, Austin, TX

Multiscale Biomaterial Design

4:15 p.m. 90. Invited Speaker: From Sequence to Phase Behavior to Self-Assembly: Molecular Design of Nanoparticle Drug Delivery, Ashutosh Chilkoti, PhD

4:45 p.m. 91. A Generalized Large Deformation Structural Constitutive Model for Forming Tissues in Needled Non-Woven Scaffolds, M. S. Sacks*, The University of Texas at Austin, Austin, TX

5:00 p.m. 92. Carbon Nanotube-Based Bio-impedimetric Bone Marker Sensors, M. S. Patil*(1), M. Ramanathan(1), V. Shanov(2), P. N. Kumta(1), (1)University of Pittsburgh, Pittsburgh, PA, (2)University of Cincinnati, Cincinnati, OH

5:15 p.m. 93. Synthesis of Large Pore Sized Mesoporous Silica Nanoparticles Embedded with Magnetic Nanoparticles for Loadingof Large Sized Molecules, B. G. Cha*, J. Kim, Sungkyunkwan University, Suwon, Republic of Korea

5:30 p.m. 94. A Protease-Activatable Nanoparticle Contrast Agent for Molecular Imaging by Dual Energy Computed Tomography, J. Ashton*(1), C. Badea(2), J. West(1), (1)Duke University, Durham, NC, (2)Duke University Medical Center, Durham, NC

5:45 p.m. 95. Fiber Reinforced Collagen-GAG Scaffolds for Tendon Bone Junction Repair, L. Mozdzen*, R. Rodgers, J. Banks, B. A. Harley, University of Illinois, Urbana, IL

6:00 p.m. 96. Tissue Formation and Remodeling in Tissue Engineered Pulmonary Conduits, M. S. Sacks*, University of Texas at Austin, Austin, TX

Nanobiomaterial and Drug Delivery Strategies for Dental/Craniomaxillofacial Repair/Regeneration

4:15 p.m. 97. Invited Speaker: Calcium Sulfate Based Hydrogels/ Scaffolds for Cranial and Periodontal Defects, Joel Bumgardner, University of Memphis

4:45 p.m. 98. Improved Mechanical Properties of 3D Printed Calcium Phosphate Scaffolds for Craniofacial Reconstruction, J. Vella, II*, R. Trombetta, M. Hoffman, J. Inzana, H. Awad, D. Benoit, University of Rochester, Rochester, NY

5:00 p.m. 99. Partially Demineralized Macroporous (PDM) Allografts for Cranial Tissue Engineering, A. M. Emmakah*(1), H. Arman(2), R. Almousa(2), N. Bhimireddy(2), S. Musgrove(2), J. Syed(2), A. Tovar(2), C. Wunderlin(2), T. G. Chu(3), (1)Purdue University, Indianapolis, IN, (2)Indiana University-Purdue University Indianapolis, Indianapolis, IN, (3)Indiana University School of Dentistry, Indianapolis, IN

5:15 p.m. 100. Evaluation of Two Types of Chitosan Nanofiber and Collagen Membranes in Critical Size Rat Calvarial Defect, H. Su*(1), K. Liu(2), D. Abebe(2), C. Wu(3), A. Karydis(4), K. Anderson(4), P. Adatrow(4), T. Fujiwara(2), W. Haggard(2), J. Bumgardner(2), (1)University of Memphis, Memphis, TN, (2)The University of Memphis, Memphis, TN, (3)Jinan University, Guangzhou, Guangdong, China, (4)UTHSC, Memphis, TN

5:30 p.m. 101. In vitro Degradation and Physical Characterization of Antimicrobial Electrospun Polyurethane Scaffolds, M. E. E. Wright*(1), M. Yang(2), P. Santerre(1,2), (1)Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada, (2)Faculty of Dentistry, University of Toronto, Toronto, ON, Canada

5:45 p.m. 102. High Throughput Genotoxicity Assay of Nanomaterials with Single Cell Halochip Assay, Y. Qiao*, Northeastern University, Boston, MA

6:00 p.m. 103. Synthesis of Antimicrobial Di-Vinyl Monomers for Dental Restorative and Adhesive Systems, Y. Delaviz*, M. A. Nascimento, M. Yang, J. P. Santerre, University of Toronto, Toronto, ON, Canada

Orthopaedic Biomaterials

4:15 p.m. 104. High Strength Magnesium-Yttrium based Alloys Exhibiting Controlled Degradation for Musculoskeletal Medical Implant Application, D. Chou*(1), D. Hong(1), B. Lee(1), Y. Chen(2), Z. Xu(2), P. N. Kumta(1), (1)University of Pittsburgh, Pittsburgh, PA, (2)North Carolina A&T State University, Greensboro, NC

4:30 p.m. 105. Safety and Efficacy of PEEK Intramedullary Nail Fixation System using an Ovine Tibial Fracture Repair Model, M. Assad*(1), D. Beaudry(1), J. Wilson(2), B. Lussier(3), M. Chagnon(1), E. Pluhar(4), M. Cantwell(2), (1)AccelLAB Inc., Boisbriand, QC, Canada, (2)Invibio Biomaterial Solutions, Lancashire, United Kingdom, (3)Universit de Montral, Montreal, QC, Canada, (4)University of Minnesota, St. Paul, MN

4:45 p.m. 106. Long-Term Effects of Poly (caprolactone) Implantation in a Bone Defect Model, A. C. Petticoffer(1), A. Recber(1), L. Boure(2), D. Arens(2), X. Liu(1), M. Fulmer(1), R. Harten*(1), (1)DePuy Synthes, West Chester, PA, (2)AO Research Institute, Davos, Switzerland

5:00 p.m. 107. An In Situ Forming, Injectable PLGA Composite for Orthopedic Applications, P. Fisher*(1), T. Milbrandt(2), Z. Hilt(3), D. Puleo(3), (1)University of Kentucky, Escondido, CA, (2)Mayo Clinic, Rochester, MN, (3)University of Kentucky, Lexington, KY

5:15 p.m. 108. A Three Dimensional Rotating Bioreactor for the Production of Micro Engineered Bone Tissue in Large Scale-Feasibility Study, A. Grottkau(1), B. Grottkau*(2), Y. Pang(2), (1)Phillips Academy Andover, Andover, MA, (2)MassGeneral Hospital for Children, Harvard Medical School, Boston, MA

5:30 p.m. 109. In vivo Performance of Resorbable Polymer Scaffolds with Calcium Phosphate Coatings Tested in a Rabbit Critical-Sized Calvaria Model, J. Kim*(1), S. McBride(2), O. Ortiz(3), M. H. R. Mango(3), A. Darr(3), J. Kohn(3), J. O. Hollinger(2), (1)Carnegie Mellon University and Hongik University, Pittsburgh, PA, (2)Carnegie Mellon University, Pittsburgh, PA, (3)Rutgers University, Piscataway, NJ

5:45 p.m. 110. Ca2+ and cAMP Signaling in Chondrocytes is Sensitive to Hydrogel Composition and Permeability, A. E. Donius*, S. V. Bougoin, J. M. Taboas, University of Pittsburgh, Pittsburgh, PA

6:00 p.m. 111. 3D Printing of Scaffolds with Tunable Modulus and Pore Size for Investigating the Progression of Cancer-Induced Bone Disease In Vitro, U. Dadwal*(1), J. M. Page(1), A. R. Merkel(1), M. Kessler(2), J. Sterling(1), S. Guelcher(1), (1)Vanderbilt University, Nashville, TN, (2)School for Math and Science at Vanderbilt, Nashville, TN

Targeted and Target-Activated Drug Delivery

4:15 p.m. 112. Bioresponsive Hydrogel Embedded Dark-Gold Nanoswitch to Sense and Overcome Cancer Multidrug Resistance, N. Artzi*(1), J. Conde(2), N. Oliva(2), (1)MIT, HMS, Cambridge, MA, (2)MIT, Cambridge, MA

4:30 p.m. 113. Antibody-targeting of Drug-loaded Micelles to Acute Myeloid Leukemia Cells, M. P. Baranello*, S. Tau, D. S. W. Benoit, University of Rochester, Rochester, NY

4:45 p.m. 114. Nano-systems for Oral Drug Delivery, R. Carrier, Northeastern University, Boston, MA

5:00 p.m. 115. Tunable Spatiotemporal Control of Angiogenic and Osteogenic Growth Factor Delivery via Hydrogel Encapsulation and Covalent Conjugation, M. J. Meagher*, R. K. Roeder, University of Notre Dame, Notre Dame, IN

5:15 p.m. 116. Modular Effect on Click Chemicals for Bioorthogonal Ligation, J. H. Lee*(1), H. Koo(2), K. Bao(1), G. Park(3), S. H. Yun(2), H. S. Choi(3), (1)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (2)Massachusetts General Hospital and Harvard Medical School, Cambridge, MA, (3)Beth Israel Deaconess Medical Center, Boston, MA

5:30 p.m. 117. Human Fetuin-A Treatment for Demineralization of Arteriosclerosis, J. L. Cunningham*, E. S. Vasquez, K. B. Walters, C. L. Simpson, Mississippi State University, Mississippi State, MS

5:45 p.m. 118. Development of a Novel Targeted Microparticle Drug Delivery System for Cancer Medication, T. Dorney*(1), C. Clark(2), N. Comolli(2), (1)Villanova University, Philadelphia, PA, (2)Villanova University, Villanova, PA

6:00 p.m. 119. Dendrimers for Local, Targeted and Selective Treatment of Breast Cancer, N. Oliva*(1), M. Atilano(2), E. Edelman(3), N. Artzi(3), (1)MIT, Cambridge, MA, (2)Insitut Quimic de Sarria, Universitat Ramon Llull AND MIT, Barcelona, Spain, (3)Brigham and Women's Hospital, Harvard Medical School AND MIT, Cambridge, MA