Con-current Oral Abstract Presentations Session 9

Scaffold Optimization and Pre-Vascularization Strategies for Large-Area Bone Regeneration

bone; bone graft; tissue engineering

A. R. Amini, University of Connecticut Health Center, Farmington, CT

C. T. Laurencin, University of Connecticut Health Center, Farmington, Connecticut

S. P. Nukavarapu, University of Connecticut Health Center, Farmington, Connecticut

Biomimetic Citrate-Presenting Osteoinductive Composites

bioactive material; calcium phosphate(s); composite/hard tissue

R. T. Tran, The Pennsylvania State University, University Park, PA

C. Zhang, The University of Texas at Arlington, Arlington, Texas

B. Banik, The Pennsylvania State University, University Park, Pennsylvania

J. L. Brown, The Pennsylvania State University, University Park, Pennsylvania

J. Yang, The Pennsylvania State University, University Park, Pennsylvania

Development of Bioactive Glass Scaffolds for Segmental Bone Repair

bioactive glass; bone; scaffolds

M. N. Rahaman, Missouri University of Science and Technology, Rolla, MO

A novel magnesium-based bone substitutes: An alternative to autologous bone grafting to treat large bone defects

bioresorbable; bone graft; osteogenesis

K. W. K. Yeung, The University of Hong Kong, Hong Kong, Hong Kong

K. H. M. Wong, The University of Hong Kong, Hong Kong, Hong Kong

P. K. Chu, City University of Hong Kong, Hong Kong, Hong Kong

K. D. K. Luk, The University of Hong Kong, Hong Kong, Hong Kong

K. M. C. Cheung, The University of Hong Kong, Hong Kong, Hong Kong

Tethered Epidermal Growth Factor delivery for the repair of large segmental bone defects

bone; cell therapy; growth factor

J. J. Rivera, Massachusetts Institute of Technology, Cambridge, MA

M. Rodrigues, University of Pittsburgh, Pittsburgh, Pennsylvania

V. Raut, Cleveland Clinic, Cleveland, Ohio

L. M. Alvarez, Massachusetts Institute of Technology, Cambridge, Massachusetts

L. Stockdale, Massachusetts Institute of Technology, Cambridge, Massachusetts

A. Nuschke, University of Pittsburgh, Pittsburgh, Pennsylvania

C. Boehm, Cleveland Clinic, Cleveland, Ohio

D. Stolz, University of Pittsburgh, Pittsburgh, Pennsylvania

A. Wells, University of Pittsburgh, Pittsburgh, Pennsylvania

G. F. Muschler, Cleveland Clinic, Cleveland, Ohio

L. Griffith, Massachusetts Institute of Technology, Cambridge, Massachusetts

Integrin-Specific Hydrogels for the Delivery of Human Mesenchymal Stem Cells in Bone Repair

bioactive material; bone remodeling; stem/progenitor cells

A. Y. Cheng, Georgia Institute of Technology, Atlanta, GA

A. Shekaran, Georgia Institute of Technology, Atlanta, Georgia

A. J. Garcia, Georgia Institute of Technology, Atlanta, Georgia

Biomaterial-Mediated Delivery of Uncultured Rat Bone Marrow Mononuclear Cells and Culture-Expanded Mesenchymal Stem Cells for Large Bone Defect Healing

microspheres; osteogenesis; stem/progenitor cells

J. K. Wise, University of Michigan, Ann Arbor, MI

A. I. Alford, University of Michigan, Ann Arbor, Michigan

J. P. Stegemann, University of Michigan, Ann Arbor, Michigan

MSC Localization via Tissue Engineered Periosteum Mimetics Coordinates Remodeling of Bone Allografts

bone graft; hydrogel; stem/progenitor cells

M. Hoffman, University of Rochester, Rochester, NY

C. Xie, University of Rochester, Rochester, New York

D. Benoit, University of Rochester, Rochester, New York

Development of novel imaging probes for the detection of polarized macrophage subsets during foreign body reactions

foreign body reactions (response); inflammation

D. W. Baker, University of Texas at Arlington, Coppell, TX

J. Zhou, University of Texas at Arlington, Arlington, Texas

Y. Tsai, University of Texas at Arlington, Arlington, Texas

K. Patty, University of Texas at Arlington, Arlington, Texas

H. Weng, University of Texas at Arlington, Arlington, Texas

E. N. Tang, University of Texas at Arlington, Arlington, Texas

L. Tang, University of Texas at Arlington, Arlington, Texas

The Immune Response to Xenogeneic Acellular Biologic Scaffold Materials

animal model; cell-material interactions; immunoassay(s)

R. Londono, University of Pitttsburgh, Pittsburgh, PA

T. J. Keane, University of Pittsburgh, Pittsburgh, Pennsylvania

B. M. Brown, University of Pittsburgh, Pittsburgh, Pennsylvania

M. T. Wolf, University of Pittsburgh, Pittsburgh, Pennsylvania

S. F. Badylak, University of Pittsburgh, Pittsburgh, Pennsylvania

Single dose polyanhydride nanoparticle-based vaccine safely induces both cellular and humoral immunity

drug delivery/release; immune response; nanomedicine

S. Haughney, Iowa State University, Ames, IA

Y. Phanse, Iowa State University, Ames, Iowa

L. Petersen, Iowa State University, Ames, Iowa

A. Ramer-Tait, Iowa State University, Ames, Iowa

J. Hostetter, Iowa State University, Ames, Iowa

B. Narasimhan, Iowa State University, Ames, Iowa

M. Wannemuehler, Iowa State University, Ames, Iowa

Sphingosine 1-phosphate receptor three regulates implant arteriogenesis by recruitment and localization of anti-inflammatory monocytes to surrounding microvessels

angiogenesis/neovascularization; regenerative medicine; tissue engineering

A. O. Awojoodu, Georgia Institute of Technology, Atlanta, GA

Macrophage-Targeted Alginate Nanoparticles as a Non-Condensing Murine IL-10 Gene Delivery System for the Treatment of Experimental Arthritis

gene therapy/gene delivery; inflammation; nanomedicine

S. Jain, Northeastern University, Boston, MA

M. M. Amiji, Northeastern University, Boston, Massachusetts

The Influence of Keratin Biomaterial Treatment on Macrophage Phenotype in Spinal Cord Injury

hydrogel; inflammation; tissue engineering

B. Fearing, Wake Forest University Health Sciences, Winston-Salem, NC

Immunotherapy with Shear-thinning Injectable Hydrogels to Treat Obstructive Nephropathy

animal model; drug delivery/release; hydrogel

D. E. Soranno, Children's Hospital of Philadelphia, Philadelphia, PA

H. D. Lu, University of Pennsylvania, Philadelphia, Pennsylvania

H. M. Weber, University of Pennsylvania, Philadelphia, Pennsylvania

J. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Engineering Dendritic Cell Environments To Reduce Transplant Rejection By Induction Of Immune Tolerance.

immune response; microspheres; regenerative medicine

S. Srinivasan, Georgia Institute of Technology, Atlanta, GA

G. Patel, Georgia Institute of Technology, Atlanta, Georgia

U. (. Goh, Georgia Institute of Technology, Atlanta, Georgia

J. E. Babensee, Georgia Institute of Technology, Atlanta, Georgia

Dynamic Cell Culture on Shape Changing Micropatterns

cell culture; smart materials; stem/progenitor cells

K. A. Davis, Syracuse University, Syracuse, NY

J. H. Henderson, Syracuse University, Syracuse, New York

Shape-memory Cell Culture Surfaces with Dynamically Tunable Nanopatterns

smart materials

M. Ebara, National Institute for Materials Science, Tsukuba, Japan

T. Aoyagi, National Institute for Materials Science, Tsukuba, Japan

Sequential Growth Factor Delivery within Fibrin Loaded Porous  Degradable Hydrogels

angiogenesis/neovascularization; controlled release; growth factor

B. Jiang, Illinois Institute of Technology, Chicago, IL

B. Akar, Illinois Institute of Technology, Chicago, Illinois

T. Waller, Illinois Institute of Technology, Chicago, Illinois

J. Larson, Illinois Institute of Technology, Chicago, Illinois

A. Appel, Illinois Institute of Technology, Chicago, Illinois

E. Brey, Illinois Institute of Technology, Chicago, Illinois

Fibrous Hyaluronic Acid Scaffolds with Engineered Degradation through MMP Sensitivity

biodegradation; biomimetic; scaffolds

R. Wade, University of Pennsylvania, Philadelphia, PA

J. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Facile preparation of phododegradable hydrogel by photo-mediated crosslinking

degradation; hydrogel; polymerization

C. Ki, Indiana University-Purdue University Indianapolis, Indianapolis, IN

H. Shih, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

C. Lin, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

Clickable, Photodegradable Cell Culture Scaffolds to Modulate Valvular Interstitial Cell Phenotype In Situ

cell-material interactions; microstructure; smart materials

C. M. Kirschner, University of Colorado, Boulder, CO

C. M. Kirschner, University of Colorado, Boulder, Colorado

D. L. Alge, University of Colorado, Boulder, Colorado

S. T. Gould, University of Colorado, Boulder, Colorado

K. S. Anseth, University of Colorado, Boulder, Colorado

Longitudinal Monitoring of Biomaterial-associated Inflammation and Bacterial Infection in a Minimally Invasive Fashion

animal model; infection; inflammation

S. Suri, Georgia Institute of Technology, Smyrna, GA

S. Selvam, Georgia Institute of Technology, Trivandrum, India

S. M. Lehman, Georgia Institute of Technology, Atlanta, Georgia

K. Reddie, Georgia Institute of Technology, Atlanta, Georgia

N. Murthy, University of California Berkeley, Berkeley, California

A. J. Garcia, Georgia Institute of Technology, Atlanta, Georgia

Biomimetic Mineralization of Acid Polysaccharide-based Hydrogels: Inspiration from Recent Findings about Organic/mineral Interface in Bone

biocompatibility/hard tissue; biomimetic; bone

C. Zhong, Sr., Cornell University, Ithaca NY, NY

C. Chu, Cornell University, Ithaca, New York

Polar Opposite Functions of the North American Porcupine Quill and Quill-mimetic Medical Devices

biomimetic

W. Cho, MIT, Cambridge, MA

J. Ankrum, MIT, Cambrisge, Massachusetts

D. Guo, Brigham and Women's Hospital, Cambridge, Massachusetts

S. Chester, MIT, Cambridge, Massachusetts

S. Yang, Brigham and Women's Hospital, Cambridge, Massachusetts

A. Kashyap, Brigham and Women's Hospital, Cambridge, Massachusetts

G. Campbell, Brigham and Women's Hospital, Cambridge, Massachusetts

R. Wood, Harvard University, Cambridge, Massachusetts

R. Rijal, Brigham and Women's Hospital, Cambridge, Massachusetts

R. Karnik, MIT, Cambridge, Massachusetts

R. Langer, MIT, Cambridge, Massachusetts

J. Karp, Brigham and Women's Hospital, Cambridge, Massachusetts

Internal Stress in Biomimetic Coatings due to Cell-Material Interactions

adhesion; biomimetic; cell-material interactions

L. Yang, The First Affiliated Hospital of Soochow University, Suzhou, China

L. Zhang, Brown University, Providence, Rhode Island

B. W. Sheldon, Brown University, Providence, Rhode Island

T. J. Webster, Brown University, Providence, Rhode Island

Specificity of Adsorption in a Prototype Whole Blood Affinity Therapy Device for Removal of Staphylococcus aureus

adsorption; bioactive material; cytokines

R. S. Ward, Exthera Medical Corporation, Berkeley, CA

Using Biomimetic Protein Micropatterns to Guide Mesenchymal Stem Cell Differentiation

biomimetic; stem/progenitor cells; surface modification

A. Shukla, Rice University, Houston, TX

J. West, Duke University, Durham, North Carolina

Calcium Phosphate Composite as Stem Cells Delivery Vehicle for Bone Repair

biomimetic; bone graft; bone marrow

J. Chang, ETEX Corporation, Cambridge, MA

Multifunctional Matrix Self-Assembled from Matrilin-3 and Rosette Nanotubes for Cartilage Repair

biomimetic; cartilage; matrix

Y. Chen, Rhode Island Hospital/Alpert Medical School, Brown University, Providence, RI

Hyaluronic Acid - Gold Nanoparticle/Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection

drug delivery/release; gold; nanomedicine

S. Hahn, Pohang University of Science and Technology (POSTECH), pohang, Republic of Korea

M. Lee, POSTECH, Pohang, Republic of Korea

J. Yang, POSTECH, pohang, Republic of Korea

H. Jung, POSTECH, pohang, Republic of Korea

W. Hur, The Catholic University, Seoul, Republic of Korea

S. Yoon, The Catholic University, Seoul, Republic of Korea

Evaluating Cellular Interactions of Polyanhydride Particles for Intracellular Delivery of Antibiotics

cell-material interactions; drug delivery/release; infection

B. Narasimhan, Iowa State Univesrity, Ames, IA

Y. Phanse, Iowa State University, Ames, Iowa

P. A. Lueth, Iowa State University, Ames, Iowa

A. E. Ramer-Tait, University of Nebraska–Lincoln, Lincoln, Nebraska

B. R. Carrillo-Conde, University of Texas Austin, Austin, Texas

B. Narasimhan, Iowa State University, Ames, Iowa

M. J. Wannemuehler, Iowa State University, Ames, Iowa

B. H. Bellaire, Iowa State University, Ames, Iowa

Quantitative In vitro 3D Analysis of Nanomaterial Diffusion in a 3D-Atherosclerosis Model

endothelial cells; permeability; vascular

P. Chetprayoon, Graduate School of Engineering, Osaka University, Osaka, Japan

M. Matsusaki, Graduate School of Engineering, Osaka University, Osaka, Japan

M. Akashi, Graduate School of Engineering, Osaka University, Osaka, Japan

Understanding the Influence of Stent Design on Arterial Drug Distribution and Effect through Computational Modeling

computer modeling/simulation; drug delivery/release; stents

R. A. Tzafriri, CBSET Inc, Lexington, MA

E. R. Edelman, MIT, Cambridge, Massachusetts

Surface Modification of Red Blood Cells Using Novel Plasma Membrane Anchors

blood-material interface; drug delivery/release; membrane

S. Pandya, University of Texas at San Antonio, san antonio, TX

M. Salinas, University of Texas at San Antonio, San Antonio, Texas

E. Abdelaziz, University of Texas at San Antonio, san antonio, Texas

G. Negrete, University of Texas at San Antonio, san antonio, Texas

C. Agrawal, University of Texas at San Antonio, san antonio, Texas

Polymeric Microparticles for Controlled Fibrolysis in Abdominal Aortic Aneurysms (AAAs)

cardiovascular; coagulation; drug delivery/release

B. Sivaraman, Cleveland Clinic Foundation, Cleveland, OH

A. Sylvester, Case Western Reserve University & Cleveland Clinic, Cleveland, Ohio

A. Ramamurthi, Cleveland Clinic, Cleveland, Ohio

Controlled release of novel anti-biofilm agents from a poly (2-hydroxyethyl methacrylate) Scaffold for the treatment of medical device associated bacterial biofilm infections

animal model; antimicrobial; bacterial adherence

h. ma, university of washington, Seattle, WA

Synthesis of Antimicrobial Monomers Using Ciprofloxacin

antimicrobial; drug delivery/release; polymer

Y. Delaviz, University of Toronto, Toronto, ON, Canada

M. W. Laschuk, University of Toronto, Toronto, Ontario, Canada

M. Yang, University of Toronto, Toronto, Ontario, Canada

J. Santerre, University of Toronto, Toronto, Ontario, Canada

The Role of Cell Shape in Macrophage Polarization

morphology; tissue engineering

F. Y. N. McWhorter, University of California, Irvine, Irvine, CA

Cell Interaction Distance Modulates Chondrocyte Responses on Co-Cultured Scaffolds

cell-cell interactions; cell-material interactions; interface(s)

X. Zhang, Columbia University, New York, NY

K. L. Moffat, Columbia University, New York, New York

S. E. Gordon, Columbia University, New York, New York

N. H. Goldhaber, Columbia Univeristy, New York, New York

H. H. Lu, Columbia University, New York, New York

Microencapsulation of Beta Cell Spheroids for Treatment of Type 1 Diabetes

diabetes; drug delivery/release; encapsulated cells

X. Liu, Clemson University, Richmond, VA

X. Wen, Virginia Commenwealth University, Richmond, Virginia

Integration of Microfabricated Channels and Self-assembled Microvasculature to Support Engineered Hepatic Tissue

biomimetic; hydrogel; tissue engineering

S. J. Higbee, Rice University, Houston, TX

M. P. Cuchiara, Rice University, Houston, Texas

J. L. West, Duke University, Houston, Texas

Phosphorylating apatite-specific peptide inhibits osteoblast mineralization

bone; mineralization; tissue engineering

J. Ramaswamy, University of Michigan Ann Arbor, Ann Arbor, MI

H. Nam, University of Michigan Ann Arbor, Ann Arbor, Michigan

N. E. Hatch, University of Michigan Ann Arbor, Ann Arbor, Michigan

D. H. Kohn, University of Michigan Ann Arbor, Ann Arbor, Michigan

Osteogenic differentiation of ASC and MSC in modular protein/ceramic microenvironments

microspheres; orthopedic; stem/progenitor cells

R. R. Rao, University of Michigan, Ann Arbor, MI

R. R. Rao, University of Michigan, Ann Arbor, Michigan

A. W. Peterson, University of Michigan, Ann Arbor, Michigan

J. P. Stegemann, University of Michigan, Ann Arbor, Michigan

Cell Cycle Unification Based on Tuning of Cellular Environments Using Cytocompatible and Reversible Forming Phospholipid Polymeric Hydrogels

encapsulated cells; hydrogel

H. Oda, The University of Tokyo, Tokyo, Japan

T. Konno, The University of Tokyo, Tokyo, Japan

K. Ishihara, The University of Tokyo, Tokyo, Japan

3D hydrogel fibers based system to design heterotypic bone vascularization approaches

bone; cell-cell interactions; endothelial cells

S. M. Mihaila, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

E. G. Popa, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

R. L. Reis, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

A. P. Marques, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

M. E. Gomes, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

Polypropylene Surgical Mesh Coated with Extracellular Matrix Mitigates the Host Foreign Body Response

coating(s); extracellular matrix; foreign body reactions (response)

M. T. Wolf, University of Pittsburgh, Pittsburgh, PA

M. T. Wolf, University of Pittsburgh, Pittsburgh, Pennsylvania

C. A. Carruthers, University of Pittsburgh, Pittsburgh, Pennsylvania

C. L. Dearth, University of Pittsburgh, Pittsburgh, Pennsylvania

P. M. Crapo, University of Pittsburgh, Pittsburgh, Pennsylvania

A. Huber, University of Pittsburgh, Pittsburgh, Pennsylvania

O. A. Burnsed, University of Pittsburgh, Pittsburgh, Pennsylvania

R. Londono, University of Pittsburgh, Pittsburgh, Pennsylvania

S. A. Johnson, University of Pittsburgh, Pittsburgh, Pennsylvania

K. A. Daly, University of Pittsburgh, Pittsburgh, Pennsylvania

E. C. Stahl, University of Pittsburgh, Pittsburgh, Pennsylvania

J. M. Freund, University of Pittsburgh, Pittsburgh, Pennsylvania

C. J. Medberry, University of Pittsburgh, Pittsburgh, Pennsylvania

L. E. Carey, University of Pittsburgh, Pittsburgh, Pennsylvania

A. Nieponice, University of Pittsburgh, Pittsburgh, Pennsylvania

N. J. Amoroso, University of Pittsburgh, Pittsburgh, Pennsylvania

S. F. Badylak, University of Pittsburgh, Pittsburgh, Pennsylvania

Development of Automated Loom for Woven Tissue Engineering Test Systems

fiber; scaffolds; tissue engineering

J. Gilmore, Clemson University, Clemson, SC

Histological Evaluation of Abdominal Wall Defect Repair with a Novel Warp-Knit Mesh

absorbable; animal model; biocompatibility/soft tissue

G. Hilas, Poly-Med, Inc., Anderson, SC

S. Peniston, Poly-Med, Inc., Anderson, South Carolina

J. Corbett, Poly-Med, Inc., Anderson, South Carolina

Evaluation of a Polyamide-Gelatin Mesh seeded with Human Endometrial Mesenchymal Stem Cells for the repair of Pelvic Organ Prolapse

in vivo; stem/progenitor cells; women’s health

J. A. M. Ramshaw, CSIRO - Materials Science and Engineering, Clayton, Australia

D. Ulrich, Monash Institute of Medical Research, Clayton, Australia

S. L. Edwards, CSIRO - Materials Science and Engineering, Clayton, Australia

J. F. White, CSIRO - Materials Science and Engineering, Clayton, Australia

C. Su, CSIRO - Materials Science and Engineering, Clayton, Australia

K. Tan, Monash Institute of Medical Research, Clayton, Australia

A. Rosamilia, Monash University, Calyton, Australia

C. E. Gargett, Monash Institute of Medical Research, Clayton, Australia

J. A. Werkmeister, CSIRO - Materials Science and Engineering, Clayton, Australia

In Vitro Cellular Response to Surgical Mesh Materials Derived from Dermal ECM

collagen; extracellular matrix; scaffolds

K. M. Kulig, Massachusetts General Hospital, Boston, MA

X. Luo, Massachusetts General Hospital, Boston, Massachusetts

E. B. Finkelstein, Massachusetts General Hospital, Boston, Massachusetts

X. Liu, Kensey Nash Corporation, Exton, Pennsylvania

J. P. Vacanti, Massachusetts General Hospital, Boston, Massachusetts

S. Goldman, Kensey Nash Corporation, Exton, Pennsylvania

C. A. Sundback, Massachusetts General Hospital, Boston, Massachusetts

C. M. Neville, Massachusetts General Hospital, Boston, Massachusetts

Potential utility of woven flax fiber meshes in surgical repair of incisional hernias

biocompatibility/soft tissue; foreign body reactions (response); in vivo

S. A. A. Michel, Maastricht University, Maastricht, Netherlands

M. L. W. Knetsch, Maastricht University, Maastricht, Netherlands

D. G. Molin, Maastricht University, Maastricht, Netherlands

L. H. Koole, Maastricht University, Maastricht, Netherlands

Differentiation by FT-IR of Absorbable Polyesters Used in Production of Surgical Meshes

bioresorbable; glycolide; polydioxanone

K. D. Gray, Jr., Poly-Med, Inc., Anderson, SC

C. Culbreath, Poly-Med, Inc., Anderson, South Carolina

J. Corbett, Poly-Med, Inc., Anderson, South Carolina

In Vitro Degradation Property of Two Fully-Absorbable Poly(lactide-co-glycolide) Meshes

absorbable; degradation; in vitro

M. Deng, Johnson & Johnson Global Surgey Group, Somerville, NJ

M. Deng, Johnson & Johnson, Somerville, New Jersey

D. Burkley, Johnson & Johnson, Somerville, New Jersey

M. Xu, Johnson & Johnson, Somerville, New Jersey

S. Savidge, Johnson & Johnson, Somerville, New Jersey

I. Koyfman, Johnson & Johnson, Somerville, New Jersey

C. Yang, Johnson & Johnson, Somerville, New Jersey

Y. Li, Johnson & Johnson, Somerville, New Jersey